CN112771074A - 用于酶促破坏细菌生物膜的组合物和方法 - Google Patents

用于酶促破坏细菌生物膜的组合物和方法 Download PDF

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Publication number
CN112771074A
CN112771074A CN201980064002.8A CN201980064002A CN112771074A CN 112771074 A CN112771074 A CN 112771074A CN 201980064002 A CN201980064002 A CN 201980064002A CN 112771074 A CN112771074 A CN 112771074A
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CN
China
Prior art keywords
biofilm
antibody
antibodies
dna
biofilms
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Pending
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CN201980064002.8A
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English (en)
Chinese (zh)
Inventor
史蒂文·大卫·古德曼
劳伦·奥普雷马克·巴卡莱茨
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Nationwide Childrens Hospital Inc
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Nationwide Childrens Hospital Inc
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Publication date
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Publication of CN112771074A publication Critical patent/CN112771074A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/22—Endodeoxyribonucleases producing 3'-phosphomonoesters (3.1.22)
    • C12Y301/22004—Crossover junction endodeoxyribonuclease (3.1.22.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/04—Hydrolases acting on acid anhydrides (3.6) acting on acid anhydrides; involved in cellular and subcellular movement (3.6.4)
    • C12Y306/04012—DNA helicase (3.6.4.12)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980064002.8A 2018-10-05 2019-10-04 用于酶促破坏细菌生物膜的组合物和方法 Pending CN112771074A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862742158P 2018-10-05 2018-10-05
US62/742,158 2018-10-05
PCT/US2019/054868 WO2020073004A1 (en) 2018-10-05 2019-10-04 Compositions and methods for enzymatic disruption of bacterial biofilms

Publications (1)

Publication Number Publication Date
CN112771074A true CN112771074A (zh) 2021-05-07

Family

ID=70054909

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980064002.8A Pending CN112771074A (zh) 2018-10-05 2019-10-04 用于酶促破坏细菌生物膜的组合物和方法

Country Status (7)

Country Link
US (1) US12161701B2 (https=)
EP (1) EP3861021B1 (https=)
JP (2) JP7541513B2 (https=)
CN (1) CN112771074A (https=)
AU (1) AU2019355194B2 (https=)
CA (1) CA3114925A1 (https=)
WO (1) WO2020073004A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118206617A (zh) * 2024-05-20 2024-06-18 烟台大学 一类能特异性结合霍利迪连接体的多肽探针及其应用

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US20160194384A1 (en) * 2014-06-12 2016-07-07 Research Institute At Nationwide Children's Hospital Compositions and methods for the removal of biofilms

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118206617A (zh) * 2024-05-20 2024-06-18 烟台大学 一类能特异性结合霍利迪连接体的多肽探针及其应用

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AU2019355194A1 (en) 2021-04-22
US12161701B2 (en) 2024-12-10
JP2022512580A (ja) 2022-02-07
JP2024105533A (ja) 2024-08-06
AU2019355194B2 (en) 2026-04-09
EP3861021A4 (en) 2022-06-22
WO2020073004A1 (en) 2020-04-09
JP7541513B2 (ja) 2024-08-28
CA3114925A1 (en) 2020-04-09
US20210338783A1 (en) 2021-11-04
EP3861021A1 (en) 2021-08-11
EP3861021B1 (en) 2025-02-12

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