CN112739811A - 体外受精系统及其相关部件 - Google Patents

体外受精系统及其相关部件 Download PDF

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Publication number
CN112739811A
CN112739811A CN201980062267.4A CN201980062267A CN112739811A CN 112739811 A CN112739811 A CN 112739811A CN 201980062267 A CN201980062267 A CN 201980062267A CN 112739811 A CN112739811 A CN 112739811A
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CN
China
Prior art keywords
cells
biochip
well
liquid
medium
Prior art date
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Pending
Application number
CN201980062267.4A
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English (en)
Chinese (zh)
Inventor
J·A·霍卡贾达斯·阿尔曼萨
T·马丁·维拉巴
S·蒙恩
A·J·贾德
G·K·杰普斯
H·V·哈尔
E·J·斯通
M·I·沃克尔
J·P·卡西
P·L·克罗斯利
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Life Overture Co
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Life Overture Co
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Filing date
Publication date
Application filed by Life Overture Co filed Critical Life Overture Co
Publication of CN112739811A publication Critical patent/CN112739811A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/06—Bioreactors or fermenters specially adapted for specific uses for in vitro fertilization
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/14—Pressurized fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Medical Informatics (AREA)
  • Reproductive Health (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201980062267.4A 2018-09-28 2019-09-27 体外受精系统及其相关部件 Pending CN112739811A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201815880 2018-09-28
GB1815880.8 2018-09-28
PCT/US2019/053416 WO2020069290A1 (en) 2018-09-28 2019-09-27 In vitro fertilization system and components associated therewith

Publications (1)

Publication Number Publication Date
CN112739811A true CN112739811A (zh) 2021-04-30

Family

ID=69945682

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980062267.4A Pending CN112739811A (zh) 2018-09-28 2019-09-27 体外受精系统及其相关部件

Country Status (5)

Country Link
US (2) US20200102528A1 (https=)
EP (1) EP3841194A4 (https=)
JP (1) JP2022502060A (https=)
CN (1) CN112739811A (https=)
WO (1) WO2020069290A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10696937B2 (en) 2015-03-31 2020-06-30 Thrive Bioscience, Inc. Cell culture incubators with integrated cell manipulation systems
JP2022502060A (ja) 2018-09-28 2022-01-11 オーバーチュア ライフ，インコーポレイテッド 体外受精システム及びそれに関連する構成要素
EP4192373A4 (en) * 2020-08-07 2024-11-13 Overture Life, Inc. MICROFLUIDIC DEVICES AND METHODS FOR DELIVERING SOLUTIONS TO BIOLOGICAL MATERIAL
EP4228533A4 (en) * 2020-10-16 2025-09-03 Overture Life Inc MICROFLUIDIC DEVICES AND METHODS FOR CELL DENUDATION
WO2024249594A1 (en) * 2023-05-31 2024-12-05 Thrive Bioscience, Inc. Automated apparatus and method for in vitro fertilization

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070264705A1 (en) * 2003-09-10 2007-11-15 John Dodgson Apparatus and Method for Handling Cells, Embryos or Oocytes
US20090181411A1 (en) * 2006-06-23 2009-07-16 Micronics, Inc. Methods and devices for microfluidic point-of-care immunoassays
US20100323439A1 (en) * 2005-10-18 2010-12-23 The Regents Of The University Of Michigan Microfluidic cell culture device
NL1040873A (en) * 2014-07-01 2016-03-23 Emultech B V Combination of a cartridge for a microfluidic chip and a microfluidic chip.
US20160133517A1 (en) * 2014-11-07 2016-05-12 International Business Machines Corporation Self-Limited, Anisotropic Wet Etching of Transverse Vias in Microfluidic Chips
US20160278366A1 (en) * 2008-11-11 2016-09-29 H. Randall Craig Microfluidic embryo and gamete culture systems

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6193647B1 (en) 1999-04-08 2001-02-27 The Board Of Trustees Of The University Of Illinois Microfluidic embryo and/or oocyte handling device and method
WO2001088087A2 (en) 2000-05-12 2001-11-22 The Board Of Trustees Of The University Of Illinois Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation
GB0505378D0 (en) * 2005-03-16 2005-04-20 Robio Systems Ltd Fluidic devices for cell and embryo culture
EP2304016B1 (en) * 2008-07-16 2012-06-27 Cook Medical Technologies LLC Micro-fluidic cell manipulation and holding device
WO2009118014A1 (en) * 2008-08-01 2009-10-01 Smart Biosystems Aps A chamber of a bioreactor platform
CN101827931A (zh) 2008-08-29 2010-09-08 北京大学 用于可准确控制的细胞培养的微流体芯片
GB0910330D0 (en) * 2009-06-16 2009-07-29 Univ Leiden A biological microfluidics chip and related methods
WO2013004644A1 (en) 2011-07-01 2013-01-10 Universiteit Twente Microfluidic device with integrated sensors for cultivation of cells
WO2014106286A1 (en) 2013-01-07 2014-07-10 Genea Limited Method, system and apparatus for improved micromanipulation and storage
US11760965B2 (en) 2017-10-19 2023-09-19 Georgia Tech Research Corporation Mesofluidic device for culture of cell aggregates
CA3095248A1 (en) * 2018-04-18 2019-10-24 University Of Leeds Device for supporting development of a cell or tissue derived from the ovary
JP2022502060A (ja) 2018-09-28 2022-01-11 オーバーチュア ライフ，インコーポレイテッド 体外受精システム及びそれに関連する構成要素

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070264705A1 (en) * 2003-09-10 2007-11-15 John Dodgson Apparatus and Method for Handling Cells, Embryos or Oocytes
US20100323439A1 (en) * 2005-10-18 2010-12-23 The Regents Of The University Of Michigan Microfluidic cell culture device
US20090181411A1 (en) * 2006-06-23 2009-07-16 Micronics, Inc. Methods and devices for microfluidic point-of-care immunoassays
US20160278366A1 (en) * 2008-11-11 2016-09-29 H. Randall Craig Microfluidic embryo and gamete culture systems
NL1040873A (en) * 2014-07-01 2016-03-23 Emultech B V Combination of a cartridge for a microfluidic chip and a microfluidic chip.
US20160133517A1 (en) * 2014-11-07 2016-05-12 International Business Machines Corporation Self-Limited, Anisotropic Wet Etching of Transverse Vias in Microfluidic Chips

Also Published As

Publication number Publication date
JP2022502060A (ja) 2022-01-11
US12606782B2 (en) 2026-04-21
EP3841194A1 (en) 2021-06-30
WO2020069290A1 (en) 2020-04-02
US20230105188A1 (en) 2023-04-06
US20200102528A1 (en) 2020-04-02
EP3841194A4 (en) 2022-06-15

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