CN112708636A - 基因转录框架、载体系统、基因组序列编辑方法及应用 - Google Patents
基因转录框架、载体系统、基因组序列编辑方法及应用 Download PDFInfo
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- CN112708636A CN112708636A CN202110089068.1A CN202110089068A CN112708636A CN 112708636 A CN112708636 A CN 112708636A CN 202110089068 A CN202110089068 A CN 202110089068A CN 112708636 A CN112708636 A CN 112708636A
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
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- General Engineering & Computer Science (AREA)
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- Animal Behavior & Ethology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110089068.1A CN112708636A (zh) | 2021-01-22 | 2021-01-22 | 基因转录框架、载体系统、基因组序列编辑方法及应用 |
| CA3206081A CA3206081A1 (en) | 2021-01-22 | 2021-12-01 | Gene transcription framework, vector system, genome sequence editing method and application |
| AU2021422067A AU2021422067A1 (en) | 2021-01-22 | 2021-12-01 | Gene transcription framework, vector system, genome sequence editing method and application |
| JP2023541700A JP2024504592A (ja) | 2021-01-22 | 2021-12-01 | 遺伝子転写フレームワーク、ベクターシステム、ゲノム配列編集方法および応用 |
| EP21920753.7A EP4282968A4 (en) | 2021-01-22 | 2021-12-01 | GENE TRANSCRIPTION FRAMEWORK, VECTOR SYSTEM, GENOME SEQUENCE EDITING METHOD AND APPLICATION |
| KR1020237028513A KR20230135630A (ko) | 2021-01-22 | 2021-12-01 | 유전자 전사 프레임워크, 벡터 시스템, 게놈 서열 편집 방법 및 응용 |
| US18/266,592 US20250263737A1 (en) | 2021-01-22 | 2021-12-01 | Gene transcription framework, vector system, genome sequence editing method and application |
| PCT/CN2021/134710 WO2022156378A1 (zh) | 2021-01-22 | 2021-12-01 | 基因转录框架、载体系统、基因组序列编辑方法及应用 |
| MX2023008635A MX2023008635A (es) | 2021-01-22 | 2021-12-01 | Marco para la transcripción de genes, sistema de vectores, método para editar la secuencia genómica y aplicación. |
| BR112023014382A BR112023014382A2 (pt) | 2021-01-22 | 2021-12-01 | Estrutura de transcrição gênica, sistema vetorial, método de edição da sequência do genoma e aplicação |
| ZA2023/08025A ZA202308025B (en) | 2021-01-22 | 2023-08-18 | Gene transcription framework, vector system, genome sequence editing method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110089068.1A CN112708636A (zh) | 2021-01-22 | 2021-01-22 | 基因转录框架、载体系统、基因组序列编辑方法及应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112708636A true CN112708636A (zh) | 2021-04-27 |
Family
ID=75550451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110089068.1A Pending CN112708636A (zh) | 2021-01-22 | 2021-01-22 | 基因转录框架、载体系统、基因组序列编辑方法及应用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20250263737A1 (https=) |
| EP (1) | EP4282968A4 (https=) |
| JP (1) | JP2024504592A (https=) |
| KR (1) | KR20230135630A (https=) |
| CN (1) | CN112708636A (https=) |
| AU (1) | AU2021422067A1 (https=) |
| BR (1) | BR112023014382A2 (https=) |
| CA (1) | CA3206081A1 (https=) |
| MX (1) | MX2023008635A (https=) |
| WO (1) | WO2022156378A1 (https=) |
| ZA (1) | ZA202308025B (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112481259A (zh) * | 2020-11-24 | 2021-03-12 | 南昌大学 | 两种甘薯U6基因启动子IbU6的克隆与应用 |
| CN115044583A (zh) * | 2022-03-21 | 2022-09-13 | 隋云鹏 | 用于基因编辑的rna框架和基因编辑方法 |
| CN115312121A (zh) * | 2022-09-29 | 2022-11-08 | 北京齐碳科技有限公司 | 靶基因位点检测方法、装置、介质及程序产品 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102080101A (zh) * | 2010-11-25 | 2011-06-01 | 北京济福霖生物技术有限公司 | 一种定点整合外源基因的方法 |
| WO2016030501A1 (en) * | 2014-08-28 | 2016-03-03 | Centre National De La Recherche Scientifique - Cnrs - | Synthetic alu-retrotransposon vectors for gene therapy |
| US20190153528A1 (en) * | 2016-02-12 | 2019-05-23 | Jumpcode Genomics, Inc. | Method for target specific rna transcription of dna sequences |
| US20200109398A1 (en) * | 2018-08-28 | 2020-04-09 | Flagship Pioneering, Inc. | Methods and compositions for modulating a genome |
| CN112210573A (zh) * | 2020-10-14 | 2021-01-12 | 浙江大学 | 一种用基因编辑改造原代细胞的dna模板及定点插入方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2281050B1 (en) * | 2008-04-14 | 2014-04-02 | Sangamo BioSciences, Inc. | Linear donor constructs for targeted integration |
| US20210340562A1 (en) * | 2018-10-19 | 2021-11-04 | Board Of Regents, The University Of Texas System | Engineered long interspersed element (line) transposons and methods of use |
| JP7831937B2 (ja) * | 2019-09-03 | 2026-03-17 | クリエイト・メディシンズ,インコーポレーテッド | ゲノム組込みのための方法および組成物 |
-
2021
- 2021-01-22 CN CN202110089068.1A patent/CN112708636A/zh active Pending
- 2021-12-01 JP JP2023541700A patent/JP2024504592A/ja active Pending
- 2021-12-01 US US18/266,592 patent/US20250263737A1/en active Pending
- 2021-12-01 AU AU2021422067A patent/AU2021422067A1/en active Pending
- 2021-12-01 BR BR112023014382A patent/BR112023014382A2/pt unknown
- 2021-12-01 EP EP21920753.7A patent/EP4282968A4/en active Pending
- 2021-12-01 CA CA3206081A patent/CA3206081A1/en active Pending
- 2021-12-01 WO PCT/CN2021/134710 patent/WO2022156378A1/zh not_active Ceased
- 2021-12-01 MX MX2023008635A patent/MX2023008635A/es unknown
- 2021-12-01 KR KR1020237028513A patent/KR20230135630A/ko active Pending
-
2023
- 2023-08-18 ZA ZA2023/08025A patent/ZA202308025B/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102080101A (zh) * | 2010-11-25 | 2011-06-01 | 北京济福霖生物技术有限公司 | 一种定点整合外源基因的方法 |
| WO2016030501A1 (en) * | 2014-08-28 | 2016-03-03 | Centre National De La Recherche Scientifique - Cnrs - | Synthetic alu-retrotransposon vectors for gene therapy |
| US20190153528A1 (en) * | 2016-02-12 | 2019-05-23 | Jumpcode Genomics, Inc. | Method for target specific rna transcription of dna sequences |
| US20200109398A1 (en) * | 2018-08-28 | 2020-04-09 | Flagship Pioneering, Inc. | Methods and compositions for modulating a genome |
| CN112210573A (zh) * | 2020-10-14 | 2021-01-12 | 浙江大学 | 一种用基因编辑改造原代细胞的dna模板及定点插入方法 |
Non-Patent Citations (2)
| Title |
|---|
| PRESCOTT DEININGER: "Alu elements: know the SINEs", 《GENOME BIOLOGY》 * |
| YIFAN WANG等: "BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance", 《NATURE COMMUNICATION》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112481259A (zh) * | 2020-11-24 | 2021-03-12 | 南昌大学 | 两种甘薯U6基因启动子IbU6的克隆与应用 |
| CN112481259B (zh) * | 2020-11-24 | 2022-09-16 | 南昌大学 | 两种甘薯U6基因启动子IbU6的克隆与应用 |
| CN115044583A (zh) * | 2022-03-21 | 2022-09-13 | 隋云鹏 | 用于基因编辑的rna框架和基因编辑方法 |
| WO2023179132A1 (zh) * | 2022-03-21 | 2023-09-28 | 隋云鹏 | 用于基因编辑的rna框架和基因编辑方法 |
| CN115312121A (zh) * | 2022-09-29 | 2022-11-08 | 北京齐碳科技有限公司 | 靶基因位点检测方法、装置、介质及程序产品 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4282968A4 (en) | 2024-12-04 |
| JP2024504592A (ja) | 2024-02-01 |
| BR112023014382A2 (pt) | 2023-10-31 |
| US20250263737A1 (en) | 2025-08-21 |
| ZA202308025B (en) | 2024-03-27 |
| CA3206081A1 (en) | 2022-07-28 |
| AU2021422067A1 (en) | 2023-09-07 |
| KR20230135630A (ko) | 2023-09-25 |
| MX2023008635A (es) | 2023-10-17 |
| EP4282968A1 (en) | 2023-11-29 |
| WO2022156378A1 (zh) | 2022-07-28 |
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