CN112587804A

CN112587804A - Peripheral nerve repair device combining light stimulation and nerve conduit technology

Info

Publication number: CN112587804A
Application number: CN202011559004.5A
Authority: CN
Inventors: 穆宁; 张开元; 陈图南; 王化斌; 冯华; 马康; 杨川艳; 赖颖; 王诗
Original assignee: Chongqing University; First Affiliated Hospital of PLA Military Medical University; Chongqing Institute of Green and Intelligent Technology of CAS
Current assignee: Chongqing University; First Affiliated Hospital of PLA Military Medical University; Chongqing Institute of Green and Intelligent Technology of CAS
Priority date: 2020-12-25
Filing date: 2020-12-25
Publication date: 2021-04-02

Abstract

The invention discloses a peripheral nerve repairing device combining light stimulation and nerve conduit technology, and particularly relates to the technical field of peripheral nerve repairing, wherein the peripheral nerve repairing device comprises a driving power supply and a conduit main body, the conduit main body is arranged at the bridge joint of peripheral nerve defects, the output end of the driving power supply is electrically connected with light source equipment, the output end of the light source equipment is electrically connected with a connector, the output end and the input end of the connector are both connected with connecting cables, the connector is electrically connected with an LED irradiation contact pin through the connecting cables, the end part of the LED irradiation contact pin is provided with a plurality of annularly arranged lamp beads, the input end of the LED irradiation contact pin is electrically connected with a medical cable, and one end of the medical cable, which is far away from the LED irradiation contact pin. The whole peripheral nerve repairing device combines the nerve conduit with the optogenetic technology, enhances or supplements the nerve regeneration after the operation repair, and effectively improves the regeneration repairing effect of the conduit main body and the nerve stump.

Description

Peripheral nerve repair device combining light stimulation and nerve conduit technology

Technical Field

The invention relates to the technical field of peripheral nerve repair, in particular to a peripheral nerve repair device combining light stimulation and nerve conduit technology.

Background

Peripheral nerve injury is a complex challenge faced by neurosurgery and orthopaedics in modern war and society, war trauma, motor vehicle accidents, bone fracture, laceration and the like are all reasons for peripheral nerve injury, and diabetes, tumor and operation factors are also reasons for peripheral nerve injury, iatrogenic peripheral nerve injury also frequently occurs, about 13-23 people suffer from peripheral nerve injury in every 10 ten thousand people every year in the world, 83% of patients are male, and 59% of patients are 18-35 years old, neuralgia and paralysis caused by injured sensation and dyskinesia have serious influence on the life quality of the patients, and sequelae with different degrees exist; and peripheral nerve injury person is in hospital long time, recovered slowly, and medical treatment expenditure is also higher than other patients far away, and at present, nerve injury patient function recovery prior art mainly has: (1) electromagnetic stimulation (2) nerve guide catheter (3) cell transplantation (4) optogenetics;

when a long distance defect is caused by peripheral nerve injury, tension-free nerve suturing (nerve stump suturing) cannot be completely realized, some form of graft needs to be inserted between nerve stumps to bridge a gap and support axon regeneration, the implantation of an autologous nerve graft is generally donated from another part of the body with less important function and is considered as gold standard therapy for peripheral nerve gap repair, however, the autologous nerve graft has inherent disadvantages including limited supply of donor nerves, requirement of secondary operation, morbid state of the donor part, mismatch of the donor nerves and the receptor part and poor application effect;

regeneration of peripheral nerves following injury is a complex process involving different stages of neuronal activation, wallerian degeneration, inflammatory response, revascularization, axonal growth and myelination (cottin and Lloyd 2016). Electromagnetic stimulation acts on all types of cells (neurons, schwann cells and other cells), optogenetics can selectively stimulate special cells in different stages with different lights (schwann cells (SCs) are important components of a neural network and play an important role in peripheral nerve regeneration, and photostimulation activates neuron-induced nerve growth factors and BDNFs to have positive effects on neuron cell bodies and SCs;

to this end, we propose a peripheral nerve repair device combining light stimulation and nerve conduit technology.

Disclosure of Invention

Therefore, the invention provides a peripheral nerve repairing device combining light stimulation and nerve conduit technology, and aims to solve the problems that donor nerves are not matched with receptor parts in the existing autologous nerve transplantation, peripheral nerve repairing regeneration is slow, and the recovery effect is poor.

In order to achieve the above purpose, the invention provides the following technical scheme:

a peripheral nerve repair device combining light stimulation and nerve conduit technology comprises a driving power supply and a conduit main body, the catheter main body is arranged at the bridging position of the peripheral nerve defect, the output end of the driving power supply is electrically connected with light source equipment, the output end of the light source equipment is electrically connected with a connector, the output end and the input end of the connector are both connected with connecting cables, the connector is electrically connected with an LED irradiation contact pin through a connecting cable, the end part of the LED irradiation contact pin is provided with a plurality of lamp beads arranged in a ring shape, the input end of the LED irradiation contact pin is electrically connected with a medical cable, and one end of the medical cable far away from the LED irradiation contact pin is connected with a connecting seat which is electrically connected with a connecting cable at one end of the connector, the LED irradiation insertion needle penetrates through the human epidermis layer and points to the catheter main body at the bridging part of the peripheral nerve defect, and an application is arranged outside the LED irradiation insertion needle.

Furthermore, the structure of the connector is set to be in a rotary connection mode, and the connection structure is installed quickly and reliably.

Further, the input end of the connector is electrically connected with the light source equipment through a connecting cable.

Furthermore, the medical cable is composed of an inner conductor, a first insulating layer, a wrapping tape, a thermosensitive wire, a filling part, a second insulating layer and an outer sheath from inside to outside in sequence, and has the characteristics of high energy transmission and high transmission speed.

Further, the first insulating layer is made of perfluoroethylene propylene copolymer, and the second insulating layer is made of polytetrafluoroethylene.

Further, the inner conductor is arranged to be a 7/0.08 silver-plated copper wire.

Furthermore, the structure of the catheter main body is a single-cavity hollow cylindrical tube, a nerve guide channel is arranged in the catheter main body, a plurality of through holes are linearly distributed on the outer side wall of the catheter main body along the outer side wall of the catheter main body, physical fillers are added into the nerve guide channel to simulate a common endoneurium-like structure in an autologous nerve graft, a microenvironment for peripheral nerve repair is increased, and the catheter main body is a tissue engineering nerve graft and mainly used for guiding and protecting axon regeneration of damaged nerves.

Furthermore, a display screen, an adjusting knob, an indicator light and an on-off key are arranged outside the driving power supply, and a light source with proper parameters is adjusted.

Furthermore, one side of applying ointment or plaster is equipped with the limit sleeve who shines the contact pin and cup joint mutually with LED, and applies ointment or plaster and be close to one side lateral wall of limit sleeve and be equipped with a plurality of bonding portions, applies ointment or plaster and contact and form the bonding through bonding portion with human epidermis.

Furthermore, an air bag is arranged on one side, away from the limiting sleeve, of the application, a through groove communicated with the limiting sleeve is formed in the air bag, the LED irradiation contact pin is inserted into the through groove, an inflation tube is arranged at the end portion of the air bag, the air bag on one side of the application is inflated from one end of the inflation tube, and the application is extruded after the air bag is expanded.

The invention has the following advantages:

1. in the invention, the whole peripheral nerve repairing device combines the nerve conduit with the optogenetic technology, enhances or supplements the nerve regeneration after the surgical repair, and effectively improves the regeneration repairing effect of the conduit main body and the nerve stump;

2. according to the LED irradiation contact pin device, the application patch and the air bag are arranged, after the LED irradiation contact pin is implanted into a human body, the application patch is in contact with the epidermis of the human body and forms bonding through the bonding part, meanwhile, the air bag on one side of the application patch is inflated from one end of the inflation tube, so that the air bag is extruded to the application patch after being expanded, the positions except the LED irradiation contact pin are all in a compressed state, the implantation structure of the LED irradiation contact pin can be effectively guaranteed, the stability of the irradiation process is improved, and the use reliability of the whole device is improved.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It should be apparent that the drawings in the following description are merely exemplary, and that other embodiments can be derived from the drawings provided by those of ordinary skill in the art without inventive effort.

The structures, ratios, sizes, and the like shown in the present specification are only used for matching with the contents disclosed in the specification, so as to be understood and read by those skilled in the art, and are not used to limit the conditions that the present invention can be implemented, so that the present invention has no technical significance, and any structural modifications, changes in the ratio relationship, or adjustments of the sizes, without affecting the effects and the achievable by the present invention, should still fall within the range that the technical contents disclosed in the present invention can cover.

FIG. 1 is a schematic view of the overall structure provided by the present invention;

FIG. 2 is an enlarged view of the portion A in FIG. 1 according to the present invention;

FIG. 3 is a cross-sectional view of section B-B of FIG. 1 in accordance with the present invention;

FIG. 4 is a perspective view of an LED illumination pin provided in accordance with the present invention;

FIG. 5 is a perspective view of a catheter body provided by the present invention;

FIG. 6 is a front view of the application provided by the present invention;

FIG. 7 is a perspective view of an air bag provided by the present invention;

in the figure: 1. a drive power supply; 2. a light source device; 3. a connector; 4. connecting a cable; 5. connecting a base; 6. a medical cable; 7. LED irradiates the contact pin; 8. a lamp bead; 9. a catheter body; 10. a through hole; 11. a nerve guide channel; 12. applying; 13. an air bag; 14. a through groove; 15. an inflation tube; 16. an adhesive portion; 17. a limiting sleeve; 18. an outer sheath; 19. a second insulating layer; 20. an inner conductor; 21. a first insulating layer; 22. wrapping a tape; 23. a heat-sensitive wire; 24. a filling section; 25. a display screen; 26. adjusting a knob; 27. an indicator light; 28. and (5) switching a key.

Detailed Description

The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to the attached drawings 1-5 of the specification, the peripheral nerve repair device combining light stimulation and nerve conduit technology of the embodiment comprises a driving power supply 1 and a conduit main body 9, wherein the conduit main body 9 is arranged at the bridge of peripheral nerve defects to bridge gaps and support axon regeneration, the output end of the driving power supply 1 is electrically connected with a light source device 2, the output end of the light source device 2 is electrically connected with a connector 3, the output and input ends of the connector 3 are connected with connecting cables 4, the connector 3 is electrically connected with an LED irradiation insertion needle 7 through the connecting cables 4, the end of the LED irradiation insertion needle 7 is provided with a plurality of annularly arranged lamp beads 8, the light genetic stimulation of the LED irradiation insertion needle 7 can promote the proliferation, differentiation and myelination of in vitro SC, and activate neuron-induced nerve growth factors and brain neurotrophic factors to have positive effects on neuron cell bodies and SCs, the medical cable 6 is connected to the input end of the LED irradiation contact pin 7 in an electric connection mode, the end, far away from the LED irradiation contact pin 7, of the medical cable 6 is connected with the connecting seat 5, the medical cable 6 has the advantages of being high in energy transmission and high in transmission speed, the connecting seat 5 is electrically connected with the connecting cable 4 at one end of the connector 3, the LED irradiation contact pin 7 penetrates through the position, pointing to the catheter main body 9 of the bridging portion of the peripheral nerve defect, of the human epidermis layer, and the application paste 12 is arranged outside the LED irradiation contact pin 7.

Furthermore, the connector 3 is structurally arranged in a rotary connection mode, and the connection structure is installed quickly and reliably.

Further, the input end of the connector 3 is electrically connected with the light source device 2 through a connecting cable 4

Further, the medical cable 6 is composed of an inner conductor 20, a first insulating layer 21, a wrapping tape 22, a thermosensitive wire 23, a filling part 24, a second insulating layer 19 and an outer sheath 18 from inside to outside in sequence, and has the characteristics of high energy transmission and high transmission speed.

Further, the first insulating layer 21 is made of perfluoroethylene propylene copolymer, and the second insulating layer 19 is made of polytetrafluoroethylene.

Further, the inner conductor 20 is provided as a 7/0.08 silver-plated copper wire.

Further, the structure of the catheter main body 9 is a single-cavity hollow cylindrical tube, a nerve guide channel 11 is arranged inside the catheter main body 9, a plurality of through holes 10 are linearly distributed on the outer side wall of the catheter main body 9 outside the catheter main body 9, physical fillers are added into the nerve guide channel 11 to simulate a common endoneurium-like structure in an autologous nerve graft and increase a microenvironment for peripheral nerve repair, and the catheter main body 9 is a tissue engineering nerve graft and mainly guides and protects axon regeneration of damaged nerves.

Further, a display screen 25, an adjusting knob 26, an indicator lamp 27 and an on-off key 28 are arranged outside the driving power supply 1, and a light source with proper parameters is adjusted.

The implementation scenario is specifically as follows: firstly, performing an operation on a diseased part of a patient, inserting a catheter main body 9 between nerve stumps to bridge a gap and support axon regeneration, simultaneously adding physical filler into a nerve guide channel 11 to simulate a common endoneurium-like structure in an autologous nerve graft and increase a microenvironment for peripheral nerve repair, wherein the catheter main body 9 is a tissue engineering nerve graft and mainly used for guiding and protecting axon regeneration of damaged nerves;

subsequently, if it is desired to improve the effect of repair and regeneration, the adjuvant treatment can be carried out by using the optogenetic technique, specifically, the minimally invasive surgery is carried out on the affected part of the patient, the LED irradiation insertion needle 7 is penetrated through the position of the catheter main body 9 of the bridging part of the human epidermal layer pointing to the peripheral nerve defect, the medical cable 6 connected with one end of the LED irradiation insertion needle 7 is connected with the light source equipment 2 through the connector 3, the light source equipment 2 adjusts the light source with proper parameters under the driving of the driving power supply 1, for example, the light source intensity is 5mW/mm2, the frequency is 20Hz, the propagation, differentiation and myelination of in vitro SC can be promoted by the optogenetic stimulation of irradiating the contact pin 7 by a constant LED with the duration of 1 hour, 1 second stimulation/1 second rest and the pulse width of 5 milliseconds, and the activation of neuron-induced nerve growth factors and brain-derived neurotrophic factors has positive effects on neuron cell bodies and SCs;

the whole peripheral nerve repairing device combines the nerve conduit with the optogenetic technology, enhances or supplements the nerve regeneration after the operation repair, and effectively improves the regeneration repairing effect of the conduit main body 9 and the nerve stump.

Referring to the attached figures 1, 6 and 7 of the specification, in the peripheral nerve repairing device combining the light stimulation and the nerve conduit technology, one side of the application 12 is provided with a limiting sleeve 17 sleeved with the LED irradiation insertion needle 7, the outer side wall of one side of the application 12 close to the limiting sleeve 17 is provided with a plurality of bonding parts 16, and the application 12 is in contact with the epidermis of a human body and forms bonding through the bonding parts 16.

Further, an air bag 13 is arranged on one side, away from the limiting sleeve 17, of the application plaster 12, a through groove 14 communicated with the limiting sleeve 17 is formed in the air bag 13, the LED irradiation pins 7 are inserted into the through groove 14, an inflation tube 15 is arranged at the end portion of the air bag 13, and the air bag 13 on one side of the application plaster 12 is inflated from one end of the inflation tube 15, so that the application plaster 12 is squeezed after the air bag 13 is expanded.

The implementation scenario is specifically as follows: one side of applying ointment or plaster 12 is equipped with the spacing sleeve 17 that cup joints mutually with LED irradiation contact pin 7, LED irradiates contact pin 7 and implants human back, apply ointment or plaster 12 and human epidermis contact and form the bonding through bonding portion 16, and simultaneously, aerify the gasbag 13 of applying ointment or plaster 12 one side from the one end of gas tube 15, make gasbag 13 bulge back to applying ointment or plaster 12 produce the extrusion, make except that LED irradiates contact pin 7 position department and all be in the state of sticising, can effectively guarantee LED and shine contact pin 7's implantation structure, improve the stability of irradiation process, the use reliability of the device of improvement.

Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims

1. A peripheral nerve repair device combining light stimulation and nerve conduit technology, which comprises a driving power supply (1) and a conduit main body (9), wherein the conduit main body (9) is arranged at the bridge of peripheral nerve defects, and is characterized in that: the output end of the driving power supply (1) is electrically connected with a light source device (2), the output end of the light source device (2) is electrically connected with a connector (3), the output and input ends of the connector (3) are connected with connecting cables (4), the connector (3) is electrically connected with an LED irradiation contact pin (7) through the connecting cables (4), the end part of the LED irradiation contact pin (7) is provided with a plurality of lamp beads (8) which are arranged in an annular shape, the input end of the LED irradiation contact pin (7) is electrically connected with a medical cable (6), one end of the medical cable (6) far away from the LED irradiation contact pin (7) is connected with a connecting seat (5), the connecting seat (5) is electrically connected with the connecting cables (4) at one end of the connector (3), the LED irradiation contact pin (7) pierces through a conduit main body (9) at the defect bridging part of the human body pointing peripheral nerve, an application paste (12) is arranged outside the LED irradiation contact pin (7).

2. A peripheral nerve repair device in combination with light stimulation and nerve conduit technology as claimed in claim 1, wherein: the connector (3) is configured to be rotatably connected.

3. A peripheral nerve repair device in combination with light stimulation and nerve conduit technology as claimed in claim 1, wherein: the input end of the connector (3) is electrically connected with the light source equipment (2) through a connecting cable (4).

4. A peripheral nerve repair device in combination with light stimulation and nerve conduit technology as claimed in claim 1, wherein: the medical cable (6) is composed of an inner conductor (20), a first insulating layer (21), a wrapping tape (22), a thermosensitive wire (23), a filling part (24), a second insulating layer (19) and an outer sheath (18) from inside to outside in sequence.

5. A combined light stimulation and nerve conduit technology peripheral nerve repair device as claimed in claim 4, wherein: the first insulating layer (21) is made of perfluoroethylene propylene copolymer, and the second insulating layer (19) is made of polytetrafluoroethylene.

6. A combined light stimulation and nerve conduit technology peripheral nerve repair device as claimed in claim 4, wherein: the inner conductor (20) is set to be a 7/0.08 silver-plated copper wire.

7. A peripheral nerve repair device in combination with light stimulation and nerve conduit technology as claimed in claim 1, wherein: the structure of pipe main part (9) is single inner chamber hollow cylindrical pipe, and the inside of pipe main part (9) is equipped with nerve guide way (11), the outside of pipe main part (9) is linear distribution along pipe main part (9) lateral wall and has a plurality of through-holes (10).

8. A peripheral nerve repair device in combination with light stimulation and nerve conduit technology as claimed in claim 1, wherein: the display screen (25), the adjusting knob (26), the indicating lamp (27) and the on-off key (28) are arranged outside the driving power supply (1).

9. A peripheral nerve repair device in combination with light stimulation and nerve conduit technology as claimed in claim 1, wherein: one side of the application plaster (12) is provided with a limiting sleeve (17) which is sleeved with the LED irradiation contact pin (7), and the outer side wall of one side of the application plaster (12) close to the limiting sleeve (17) is provided with a plurality of bonding parts (16).

10. A peripheral nerve repair device in combination with light stimulation and nerve conduit technology according to claim 9, wherein: an air bag (13) is arranged on one side, away from the limiting sleeve (17), of the application plaster (12), a through groove (14) communicated with the limiting sleeve (17) is formed in the air bag (13), the LED irradiation contact pin (7) is inserted into the through groove (14), and an inflation tube (15) is arranged at the end portion of the air bag (13).