CN112546668A - Rapid extraction method for realizing biomedical drug extraction - Google Patents
Rapid extraction method for realizing biomedical drug extraction Download PDFInfo
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- CN112546668A CN112546668A CN202110000644.0A CN202110000644A CN112546668A CN 112546668 A CN112546668 A CN 112546668A CN 202110000644 A CN202110000644 A CN 202110000644A CN 112546668 A CN112546668 A CN 112546668A
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- 238000000605 extraction Methods 0.000 title claims abstract description 56
- 239000003814 drug Substances 0.000 title claims abstract description 30
- 229940079593 drug Drugs 0.000 title claims abstract description 19
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 102
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 51
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 51
- 239000012530 fluid Substances 0.000 claims abstract description 43
- 239000000126 substance Substances 0.000 claims abstract description 7
- 238000011049 filling Methods 0.000 claims abstract description 4
- 238000001816 cooling Methods 0.000 claims description 61
- 238000007789 sealing Methods 0.000 claims description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 8
- 230000006835 compression Effects 0.000 claims description 6
- 238000007906 compression Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000001556 precipitation Methods 0.000 claims description 6
- 238000009833 condensation Methods 0.000 claims description 3
- 230000005494 condensation Effects 0.000 claims description 3
- 239000000498 cooling water Substances 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 3
- 238000011946 reduction process Methods 0.000 claims description 3
- 230000007246 mechanism Effects 0.000 abstract description 16
- 239000007788 liquid Substances 0.000 abstract description 13
- 238000005273 aeration Methods 0.000 abstract description 7
- 238000002156 mixing Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 239000007789 gas Substances 0.000 description 16
- 238000003825 pressing Methods 0.000 description 14
- 238000000926 separation method Methods 0.000 description 12
- 238000005057 refrigeration Methods 0.000 description 7
- 230000002457 bidirectional effect Effects 0.000 description 5
- 238000004891 communication Methods 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000000741 silica gel Substances 0.000 description 4
- 229910002027 silica gel Inorganic materials 0.000 description 4
- 229910000831 Steel Inorganic materials 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 238000000194 supercritical-fluid extraction Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0203—Solvent extraction of solids with a supercritical fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0292—Treatment of the solvent
- B01D11/0296—Condensation of solvent vapours
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Abstract
The invention discloses a rapid extraction method for extracting biomedical drugs; s1, firstly, filling a soak solution of the medicine into a tank body, and introducing supercritical carbon dioxide fluid into an air vent pipe; s2, introducing carbon dioxide fluid into the bottom of the tank body, and then fully contacting the carbon dioxide fluid with the medicine extract to selectively dissolve out the chemical components; s3, then introducing the high-pressure carbon dioxide fluid containing the extract into the shell through a communicating pipe; s4, after the pressure is reduced, the solubility of the carbon dioxide fluid is sharply reduced to precipitate a solute, the solute and the carbon dioxide gas are automatically separated, and the solute is periodically released from a discharge hole at the bottom; the communicating pipe is provided with a plurality of aeration openings, so that the contact area of the supercritical gas and the extraction liquid is increased, the mixing rate of the supercritical gas and the extraction liquid is increased, and the extraction effect is improved; through setting up safety mechanism, reach safe pressure release, increase the security of equipment use.
Description
Technical Field
The invention belongs to the field of extraction, and particularly relates to a rapid extraction method for extracting biomedical drugs.
Background
The solubility or partition coefficient of a substance in two mutually insoluble (or slightly soluble) solvents is used to transfer the substance from one solvent to the other. Extracting most compounds repeatedly; when extracting the medicine, the supercritical extraction is often adopted, the medicine is poured into an extraction tank body after being soaked, and supercritical fluid, generally carbon dioxide, is introduced, is a non-gaseous and non-liquid state between gas and liquid, and can exist only when the temperature and the pressure of the substance exceed critical points. Supercritical fluids are denser and more liquid-like, and have a viscosity closer to that of gases. Therefore, the supercritical fluid is an ideal extracting agent.
The existing supercritical extraction equipment has low mixing efficiency, unstable separation efficiency after extraction and low efficiency, so that repeated extraction is needed for many times, and the production efficiency is seriously influenced; the existing equipment only reduces the temperature of carbon dioxide through a common condenser pipe, so that extract liquid is separated out, the separation efficiency is low, and in the working process of a cooling box, the cooling box vibrates, the normal working efficiency of the cooling box is influenced, the cooling box is unstable in working, the phenomena of falling of accessories and the like are caused, and the service life of the cooling box is influenced; and general working pressure intensity is great, and current equipment sets up the relief valve on the pipeline and carries out the pressure release, and complex operation causes the maloperation easily, and the security performance is low, easily takes place the incident.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a rapid extraction method for realizing biomedical drug extraction, which increases the contact area of supercritical gas and extraction liquid, increases the mixing rate of the supercritical gas and the extraction liquid and improves the extraction effect by arranging a communicating pipe with a plurality of aeration ports; through setting up safety mechanism, reach safe pressure release, increase the security of equipment use.
The invention provides the following technical scheme:
a rapid extraction method for realizing biomedical drug extraction; comprises the following steps of (a) carrying out,
s1, firstly, filling the soak solution of the medicine into a tank body, and introducing the supercritical carbon dioxide fluid into a vent pipe;
s2, introducing carbon dioxide fluid into the bottom of the tank body, and then fully contacting the carbon dioxide fluid with the medicine extract to selectively dissolve out the chemical components;
s3, then introducing the high-pressure carbon dioxide fluid containing the extract into the shell through a communicating pipe;
and S4, after the pressure is reduced, the solubility of the carbon dioxide fluid is sharply reduced to precipitate the solute, the solute and the carbon dioxide gas are automatically separated, and the solute is periodically released from a discharge hole at the bottom.
Preferably, in step S2, while the carbon dioxide fluid is introduced into the casing to be depressurized and precipitate the solute, the refrigeration water tank and the water pump are communicated through the circulation pipe, and the condensation pipe inside the cooling tank forms a cold water circulation to accelerate the reduction of the temperature of the carbon dioxide gas, and the lower the temperature is, the faster the solute precipitation rate is, so that the separation rate of the extracted solute is increased, and the production efficiency is improved.
Preferably, the cooling tank is easy to vibrate during the pressure reduction process due to the high pressure of the carbon dioxide fluid during the operation.
Preferably, in step S4, when pressure is released, only the bolt needs to be screwed, the air pressure in the housing presses the pressing block through the exhaust pipe, the pressure applied to the pressing block increases, the pressing block compresses the pressure spring to separate the pressing block from the sealing block, and the other end of the pressure spring compresses the cover body to separate the cover body from the central body; .
Preferably, at the in-process of pressure release, after lid and the separation of central body, atmospheric pressure lets in the sealing box from the blast pipe, has reduced pressure for the first time, later upwards pushes up the roof through the carriage release lever, makes roof and sealing box separation, and gas is gone out from in the sealing box, carries out the secondary release, reduces pressure, carries out the secondary pressure release to the casing through this setting, reduces the impact force of pressure to the roof, greatly increased the security of pressure release process.
Preferentially, before extraction work, the rotating block is rotated clockwise, the rotating block drives the first internal thread pipe and the second internal thread pipe to move relatively, the clamping block is further driven to clamp the cooling box, the cooling box is reinforced, the stability in work is improved, and the influence of shaking on the cooling box is reduced.
Preferably, the influence of vibration on the cooling box is further reduced by arranging the guide rod connecting sleeve and the spring at the bottom of the cooling box.
Preferably, a rapid extraction method for realizing biomedical drug extraction adopts an extraction device; comprises a tank body and a shell; a communication column is arranged inside the tank body, the bottom of the communication column is connected with a vent pipe, and the other end of the vent pipe extends to the outside of the tank body; a feed inlet is formed in the top of the tank body; the other side of the tank body is connected with a communicating pipe, the other end of the communicating pipe is connected with the shell, the communicating pipe is provided with a plurality of branch pipes, and a plurality of aeration ports are arranged on the plurality of branch pipes; a cooling box is arranged inside the shell, a condensing pipe is arranged in the cooling box, a discharge hole is formed in the bottom of the cooling box, and the discharge hole is an extract liquid discharge hole; the communicating pipe is communicated with the cooling box; the bottom of the cooling box is provided with a clamping mechanism for fixing the cooling box in the shell; the top of the shell is provided with a safety mechanism, the safety mechanism comprises a sealing box, the top of the sealing box is provided with a top plate, and the top plate is connected with the sealing box in a sealing manner; the sealing box is internally provided with a central body.
Preferably, the lower part of the central body is connected with the shell, an exhaust pipe is arranged in the central body, and the exhaust pipe is communicated with the interior of the shell; the upper end of blast pipe is connected with sealed piece, sealed piece cross-section is "V" type structure, sealed piece matches and is equipped with the compact heap of "V" type, compact heap and blast pipe inner wall sealing connection.
Preferably, the other end of the pressing block is connected with a moving rod, a cover body is sleeved at a position, close to the other end, of the moving rod, the cover body is arranged above the central body, and the cover body is connected with the central body in a sealing mode.
Preferably, a pressure spring is sleeved on the movable rod, one end of the pressure spring is connected with the pressing block, and the other end of the pressure spring is connected with the cover body.
Preferably, one end of the top plate is provided with a rotating shaft, and the top plate is rotatably connected with the shell through the rotating shaft; a bolt is arranged on one side of the top plate, which is far away from the rotating shaft, and the top plate is connected with the sealing box through the bolt; one side of the top plate, which is close to the sealing cover, is provided with a rubber ring, and the top plate is connected with the sealing cover in a sealing way through the rubber ring.
Preferably, two sides of the cooling box are connected with the inner wall of the shell through the arranged connecting pieces; the clamping mechanism at the bottom of the cooling box comprises a first internal thread pipe and a second internal thread pipe, and sliding blocks are connected below the first internal thread pipe and the second internal thread pipe; the bottom of the shell is provided with a sliding chute, and the sliding chute is matched with and slidably connected with the sliding block; and a bidirectional threaded rod is arranged between the first internal threaded pipe and the second internal threaded pipe in a matched manner.
Preferably, a rotating block is arranged at the center of the bidirectional threaded rod; the outer side walls of the positions, close to the two ends, of the first internal thread pipe and the second internal thread pipe are connected with clamping blocks, and the cooling box is clamped by the clamping blocks.
Preferably, the bottom of the cooling box is symmetrically connected with two guide rods, the other ends of the guide rods are in clearance connection with sleeves, and the guide rods extend into the sleeves; the sleeve is internally provided with a spring, one end of the spring is connected with the inner wall of the sleeve, and the other end of the spring is connected with the guide rod.
Preferably, the cooling tank is connected with a circulating pipe, and a water pump and a refrigeration water tank are arranged on the circulating pipe.
Preferably, the circulation pipe extends to the outside of the case, and the water pump and the refrigerant tank are both disposed outside the case.
Preferably, the vent pipe is accessed with supercritical fluid; the supercritical fluid is carbon dioxide.
Preferably, the opposite side of pressing from both sides tight piece is equipped with the silica gel layer, and the silica gel layer includes the cooler bin, prevents to produce the friction damage cooler bin with the clamp plate.
The temperature and pressure of the supercritical carbon dioxide fluid directly influence the extraction result, the temperature is too high, carbon dioxide is easy to gasify, the property is unstable, and the extraction efficiency is low; the temperature is too low, the liquid phase density is high, the rate of solute precipitation is influenced by the high density, and the efficiency is low; therefore, the pressure P meets 8-16 MPa; the temperature T is 35-60 ℃; the density rho of the carbon dioxide fluid in the supercritical state meets 191.3-825kg/m3。
Preferably, in order to improve the safety coefficient, the pressure spring is made of steel, the wire diameter of the pressure spring is D, the thread pitch of the pressure spring is D, and the length of the pressure spring is L; the pressure P of the carbon dioxide fluid is greater than the elasticity F of the pressure spring to jack up the top plate, and P satisfies F = k.P/2; k coefficient of elasticity; P/F is N; in order to achieve secondary safe pressure relief; the pressure P of the carbon dioxide fluid and the wire diameter of the pressure spring are D, the thread pitch is D, and the length is L: p = Φ · 2D (L/D); phi is a pressure coefficient, and the value range is 0.368-24.5; the units of L, D and D are mm.
Compared with the prior art, the invention has the following beneficial effects:
(1) according to the rapid extraction method for extracting the biomedical drugs, the communicating pipe is provided with the plurality of aeration openings, so that the contact area of the supercritical gas and the extraction liquid is increased, the mixing rate of the supercritical gas and the extraction liquid is increased, and the extraction effect is improved.
(2) The invention relates to a rapid extraction method for realizing biomedical drug extraction, which is characterized in that a refrigeration water tank and a water pump are communicated through an arranged circulating pipe, a cold water circulation is formed by a condensing pipe in a cooling tank, the temperature of carbon dioxide gas is quickened to be reduced, the lower the temperature is, the higher the speed of separating out solute is, the separation speed of extracting solute is increased, and the production efficiency is improved.
(3) According to the rapid extraction method for extracting the biomedical drugs, the cooling box is clamped by the clamping block, so that the cooling box is reinforced, the stability in work is improved, and the influence of shaking on the cooling box is reduced; simultaneously through set up guide arm adapter sleeve and spring bottom the cooler bin, further slow down the influence of vibration to the cooler bin, prevent that the part from droing increase of service life.
(4) According to the rapid extraction method for extracting the biomedical drugs, disclosed by the invention, the shell is subjected to secondary pressure relief through the safety mechanism, so that the impact force of pressure on the top plate is reduced, and the safety of the pressure relief process is greatly improved.
(5) According to the rapid extraction method for extracting the biomedical drugs, the relationship between the pressure of the carbon dioxide fluid and the line diameter, the screw pitch and the length of the pressure spring further improves the safety performance, prevents air leakage and improves the extraction separation efficiency.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
Fig. 1 is a schematic view of the overall structure of the present invention.
Fig. 2 is a schematic view of the clamping mechanism of the present invention.
Fig. 3 is a close-up schematic of the safety mechanism of the present invention.
Fig. 4 is a schematic view of the safety mechanism of the present invention being opened.
Fig. 5 is a schematic view of the structure of the communicating pipe of the present invention.
FIG. 6 is a schematic flow diagram of the present invention.
In the figure: 1. a tank body; 2. a housing; 3. a communication column; 4. a breather pipe; 5. a feed inlet; 6. a communicating pipe; 7. a safety mechanism; 8. a cooling tank; 9. a circulation pipe; 10. a water pump; 11. a refrigeration water tank; 12. a guide bar; 13. a sleeve; 14. a spring; 15. a first internally threaded tube; 16. a second internally threaded tube; 17. a bidirectional threaded rod; 18. rotating the block; 19. a chute; 20. a slider; 21. a clamping block; 22. a branch pipe; 23. an aeration opening; 24. a discharge port; 71. a sealing cover; 72. a central body; 73. an exhaust pipe; 74. a sealing block; 75. a compression block; 76. a travel bar; 77. a pressure spring; 78. a cover body; 79. a top plate; 710. a rotating shaft; 711. and (4) bolts.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described in detail and completely with reference to the accompanying drawings. It is to be understood that the described embodiments are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
The first embodiment is as follows:
as shown in fig. 6, a rapid extraction method for biomedical drug extraction; comprises the following steps of (a) carrying out,
s1, firstly, filling the soak solution of the medicine into a tank body, and introducing the supercritical carbon dioxide fluid into a vent pipe;
s2, introducing carbon dioxide fluid into the bottom of the tank body, and then fully contacting the carbon dioxide fluid with the medicine extract to selectively dissolve out the chemical components;
s3, then introducing the high-pressure carbon dioxide fluid containing the extract into the shell through a communicating pipe;
and S4, after the pressure is reduced, the solubility of the carbon dioxide fluid is sharply reduced to precipitate the solute, the solute and the carbon dioxide gas are automatically separated, and the solute is periodically released from a discharge hole at the bottom.
In step S2, when the carbon dioxide fluid is introduced into the casing to be depressurized and precipitate the solute, the cooling water tank and the water pump are communicated through the circulation pipe, and the condensation pipe inside the cooling tank forms a cold water circulation to accelerate the reduction of the temperature of the carbon dioxide gas, and the lower the temperature is, the faster the solute precipitation rate is, so that the separation rate of the extracted solute is increased, and the production efficiency is improved.
The cooling box is easy to vibrate in the pressure reduction process due to the fact that the pressure of carbon dioxide fluid is high in the working process; before extraction, the rotating block is rotated clockwise to drive the first internal threaded pipe and the second internal threaded pipe to move relatively, the clamping block is further driven to clamp the cooling box, the cooling box is reinforced, the stability in work is improved, and the influence of shaking on the cooling box is reduced; through set up guide arm adapter sleeve and spring in the cooling tank bottom, further slow down the influence of vibration to the cooling tank.
In step S4, when pressure is released, only the bolt needs to be screwed, the air pressure in the housing presses the pressing block through the exhaust pipe, the pressure applied to the pressing block increases, the pressing block compresses the pressure spring to separate the pressing block from the sealing block, and the other end of the pressure spring compresses the cover body to separate the cover body from the central body; .
At the in-process of pressure release, after lid and the separation of central body, atmospheric pressure lets in the sealing box from the blast pipe, has reduced pressure for the first time, later through the carriage release roof that upwards backs up of carriage release lever, makes roof and sealing box separation, and gas is followed the interior effluvium of sealing box, carries out the secondary release, reduces pressure, carries out the secondary pressure release to the casing through this setting, reduces the impact force of pressure to the roof, greatly increased the security of pressure release process.
As shown in fig. 1 and 5, a rapid extraction method for extracting biomedical drugs adopts an extraction device; comprises a tank body 1 and a shell 2; a communication column 3 is arranged inside the tank body 1, the bottom of the communication column 3 is connected with a vent pipe 4, and the other end of the vent pipe 4 extends to the outside of the tank body 1; a feed inlet 5 is formed in the top of the tank body 1; the other side of the tank body 1 is connected with a communicating pipe 6, the other end of the communicating pipe 6 is connected with the shell 2, the communicating pipe 6 is provided with a plurality of branch pipes 22, and a plurality of aeration ports 23 are arranged on the plurality of branch pipes 22; a cooling box 8 is arranged inside the shell 2, a condensing pipe is arranged in the cooling box 8, a discharge hole 24 is formed in the bottom of the cooling box 8, and the discharge hole 24 is an extract liquid discharge hole 24; the communicating pipe 6 is communicated with the cooling tank 8; the bottom of the cooling box 8 is provided with a clamping mechanism, and the cooling box 8 is fixed inside the shell 2; a safety mechanism 7 is arranged at the top of the shell 2, the safety mechanism 7 comprises a sealing box 71, a top plate 79 is arranged at the top of the sealing box 71, and the top plate 79 is connected with the sealing box 71 in a sealing manner; the inside of the sealing box 71 is provided with a central body 72.
The cooling tank 8 is connected with a circulating pipe 9, and a water pump 10 and a refrigeration water tank 11 are arranged on the circulating pipe 9; the circulation pipe 9 extends to the outside of the casing 2, and the water pump 10 and the refrigeration water tank 11 are both arranged outside the casing 2; the vent pipe 4 is connected with supercritical fluid; the supercritical fluid is carbon dioxide; the opposite side of pressing from both sides tight piece 21 is equipped with the silica gel layer, and the silica gel layer includes cooling box 8, prevents to produce the friction damage cooling box 8 with the clamp plate.
Example two:
as shown in fig. 3 and 4, on the basis of the first embodiment, the lower portion of the central body 72 is connected to the housing 2, an exhaust pipe 73 is disposed inside the central body 72, and the exhaust pipe 73 is communicated with the inside of the housing 2; the upper end of blast pipe 73 is connected with sealed block 74, sealed block 74 cross-section is "V" type structure, sealed block 74 matches and is equipped with the compact heap 75 of "V" type, compact heap 75 and blast pipe 73 inner wall sealing connection.
The other end of the pressing block 75 is connected with a movable rod 76, a cover body 78 is sleeved at a position of the movable rod 76 close to the other end, the cover body 78 is arranged above the central body 72, and the cover body 78 is hermetically connected with the central body 72; a compression spring 77 is sleeved on the moving rod 76, one end of the compression spring 77 is connected with the pressing block 75, and the other end of the compression spring 77 is connected with the cover body 78.
One end of the top plate 79 is provided with a rotating shaft 710, and the top plate 79 is rotatably connected with the shell 2 through the rotating shaft 710; a bolt 711 is arranged on one side of the top plate 79, which is far away from the rotating shaft 710, and the top plate 79 is connected with the sealing box 71 through the bolt 711; and one side of the top plate 79, which is close to the sealing cover, is provided with a rubber ring, and the top plate 79 is connected with the sealing cover in a sealing way through the rubber ring.
Example three:
as shown in fig. 2, on the basis of the first embodiment, two sides of the cooling box 8 are connected with the inner wall of the housing 2 through the arranged connecting pieces; the clamping mechanism at the bottom of the cooling box 8 comprises a first internal thread pipe 15 and a second internal thread pipe 16, and sliding blocks 20 are connected below the first internal thread pipe 15 and the second internal thread; the bottom of the shell 2 is provided with a sliding groove 19, and the sliding groove 19 is matched with and slidably connected with a sliding block 20; a bidirectional threaded rod 17 is arranged between the first internal threaded pipe 15 and the second internal threaded pipe 16 in a matching manner; a rotating block 18 is arranged at the center of the bidirectional threaded rod 17; the outer side walls of the positions, close to the two ends, of the first internal threaded pipe 15 and the second internal threaded pipe 16 are respectively connected with a clamping block 21, and the cooling box 8 is clamped by the clamping blocks 21.
The bottom of the cooling box 8 is symmetrically connected with two guide rods 12, the other ends of the guide rods 12 are connected with a sleeve 13 in a clearance mode, and the guide rods 12 extend into the sleeve 13; a spring 14 is arranged in the sleeve 13, one end of the spring 14 is connected with the inner wall of the sleeve 13, and the other end of the spring 14 is connected with the guide rod 12.
Example four
The temperature and pressure of the supercritical carbon dioxide fluid directly influence the extraction result, the temperature is too high, carbon dioxide is easy to gasify, the property is unstable, and the extraction efficiency is low; the temperature is too low, the liquid phase density is high, the rate of solute precipitation is influenced by the high density, and the efficiency is low; therefore, the pressure P meets 8-16 MPa; the temperature T is 35-60 ℃; the density rho of the carbon dioxide fluid in the supercritical state meets 191.3-825kg/m3。
In order to improve the safety coefficient, the pressure spring 77 is made of steel, the wire diameter of the pressure spring 77 is D, the thread pitch is D, and the length is L; the pressure P of the carbon dioxide fluid is greater than the elastic force F of the pressure spring 77 to jack the top plate 79, and P satisfies F = k.P/2; k coefficient of elasticity; P/F is N; in order to achieve secondary safe pressure relief; the pressure P of the carbon dioxide fluid and the wire diameter of the pressure spring 77 are D, the thread pitch is D, and the length is L: p = Φ · 2D (L/D); phi is a pressure coefficient, and the value range is 0.368-24.5; the units of L, D and D are mm.
The device obtained by the technical scheme is a rapid extraction method for extracting biomedical drugs, and the communicating pipe 6 is provided with the plurality of aeration ports 23, so that the contact area of the supercritical gas and the extraction liquid is increased, the mixing rate of the supercritical gas and the extraction liquid is increased, and the extraction effect is improved; the refrigeration water tank 11 and the water pump 10 are communicated through the arranged circulating pipe 9, and a cold water circulation is formed by the condensing pipe inside the cooling tank 8, so that the temperature of carbon dioxide gas is quickened to be reduced, the lower the temperature is, the faster the solute precipitation speed is, the separation speed of the extracted solute is increased, and the production efficiency is improved; the cooling box 8 is clamped by arranging the clamping block 21, so that the cooling box 8 is reinforced, the stability in work is improved, and the influence of shaking on the cooling box 8 is reduced; meanwhile, the bottom of the cooling box 8 is provided with the guide rod 12, the connecting sleeve 13 and the spring 14, so that the influence of vibration on the cooling box 8 is further reduced, parts are prevented from falling off, and the service life is prolonged; the shell 2 is decompressed for the second time through the safety mechanism 7, so that the impact force of the pressure on the top plate 79 is reduced, and the safety of the decompression process is greatly improved; the pressure of the carbon dioxide fluid is in relation with the wire diameter, the screw pitch and the length of the pressure spring 77, so that the safety performance is further improved, air leakage is prevented, and the extraction separation efficiency is improved.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and it will be apparent to those skilled in the art that various modifications and variations can be made in the present invention; any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (7)
1. A rapid extraction method for realizing biomedical drug extraction; which is characterized by comprising the following steps of,
s1, firstly, filling the soak solution of the medicine into a tank body, and introducing the supercritical carbon dioxide fluid into a vent pipe;
s2, introducing carbon dioxide fluid into the bottom of the tank body, and then fully contacting the carbon dioxide fluid with the medicine extract to selectively dissolve out chemical components;
s3, then leading the high-pressure carbon dioxide fluid containing the extract into the shell through a communicating pipe;
and S4, after the pressure is reduced, the solubility of the carbon dioxide fluid is sharply reduced to precipitate the solute, the solute and the carbon dioxide gas are automatically separated, and the solute is periodically released from a discharge hole at the bottom.
2. The method as claimed in claim 1, wherein in step S2, the carbon dioxide fluid is introduced into the casing to reduce pressure and precipitate the solute, the cooling water tank and the water pump are connected by the circulation pipe, the cooling water circulation is formed by the condensation pipe inside the cooling tank, the temperature of the carbon dioxide gas is reduced, the lower the temperature, the faster the solute precipitation rate, the higher the extraction rate of the extracted solute, and the higher the production efficiency.
3. The method as claimed in claim 2, wherein the cooling tank is easily vibrated during the pressure reduction process due to the high pressure of the carbon dioxide fluid.
4. The method for rapidly extracting biomedical drugs according to claim 1, wherein in step S4, when releasing pressure, the bolt is only screwed, the air pressure in the casing presses the compressing block through the exhaust pipe, the pressure on the compressing block is increased, the compressing block compresses the compression spring to separate the compressing block from the sealing block, and the other end of the compression spring compresses the cap body to separate the cap body from the central body; .
5. The method for rapidly extracting the biomedical drug according to claim 4, wherein in the process of pressure relief, after the cover body is separated from the central body, the air pressure is introduced into the sealing box from the exhaust pipe, the pressure intensity is reduced for the first time, then the top plate is pushed upwards by the moving rod to separate the top plate from the sealing box, the air is discharged from the sealing box to be released for the second time, the pressure intensity is reduced, the shell is subjected to secondary pressure relief through the device, the impact force of the pressure intensity on the top plate is reduced, and the safety of the pressure relief process is greatly improved.
6. The rapid extraction method for biomedical drug extraction according to claim 3, wherein before extraction, the rotating block is rotated clockwise to drive the first internal threaded tube and the second internal threaded tube to move relatively, and further drive the clamping block to clamp the cooling box, so as to reinforce the cooling box, increase stability during operation and reduce the influence of shaking on the cooling box.
7. The rapid extraction method for biomedical medicine extraction according to claim 6, wherein the influence of vibration on the cooling tank is further reduced by arranging a guide rod connecting sleeve and a spring at the bottom of the cooling tank.
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| CN207619359U (en) * | 2017-12-11 | 2018-07-17 | 深圳市清大同创能源环境有限公司 | A kind of beer fermentation low-temperature cold accumulation device |
| CN108465267A (en) * | 2018-06-12 | 2018-08-31 | 倪菁菁 | A kind of pharmaceutical purpose supercritical extracting equipment |
| CN110523103A (en) * | 2019-09-18 | 2019-12-03 | 许良云 | A kind of supercritical carbon dioxide extraction kettle |
| CN209943171U (en) * | 2019-04-22 | 2020-01-14 | 湖北顶裕节能环保科技股份有限公司 | A FRP centrifugal fan fixing device |
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2021
- 2021-01-04 CN CN202110000644.0A patent/CN112546668A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN207619359U (en) * | 2017-12-11 | 2018-07-17 | 深圳市清大同创能源环境有限公司 | A kind of beer fermentation low-temperature cold accumulation device |
| CN108465267A (en) * | 2018-06-12 | 2018-08-31 | 倪菁菁 | A kind of pharmaceutical purpose supercritical extracting equipment |
| CN209943171U (en) * | 2019-04-22 | 2020-01-14 | 湖北顶裕节能环保科技股份有限公司 | A FRP centrifugal fan fixing device |
| CN110523103A (en) * | 2019-09-18 | 2019-12-03 | 许良云 | A kind of supercritical carbon dioxide extraction kettle |
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