CN112525834B - Online detection and analysis system and detection and analysis method for Chinese medicine liquid components - Google Patents
Online detection and analysis system and detection and analysis method for Chinese medicine liquid components Download PDFInfo
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- 238000001228 spectrum Methods 0.000 claims abstract description 17
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
- G01N2001/1418—Depression, aspiration
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
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Abstract
The invention provides an on-line detection and analysis system and a detection and analysis method for components of traditional Chinese medicine liquid, which belong to the technical field of detection equipment for components of the medicine liquid, and a medicine liquid sampling device is provided with a bypass circulation path to extract the medicine liquid to be detected from a traditional Chinese medicine extraction tank; the device comprises a filtering device, a bubble removing device, a constant temperature device, an on-line detection device and an on-line spectrum detection device, wherein the filtering device is arranged in a liquid medicine sampling path and used for filtering extracted liquid medicine to be detected, the bubble removing device is connected with the filtering device and used for removing bubbles from the filtered liquid medicine to be detected, the constant temperature device is connected with the periphery of the bubble removing device and used for maintaining the temperature of the liquid medicine to be detected, and the on-line detection device is connected with the downstream of the bubble removing device and used for carrying out component detection analysis on the filtered and bubble-removed constant temperature liquid medicine to be detected by the on-line spectrum detection device and obtaining liquid medicine component information in real time. The invention realizes the on-line detection of the liquid medicine components in the traditional Chinese medicine extraction process, overcomes the hysteresis of the off-line detection of the traditional Chinese medicine quality, provides data support for realizing the real-time standard control of the traditional Chinese medicine production, improves the production process, and improves the production efficiency and the product quality.
Description
Technical Field
The invention relates to the technical field of liquid medicine component detection equipment, in particular to a traditional Chinese medicine liquid medicine component on-line detection and analysis system and a detection and analysis method.
Background
The detection and analysis process of the extracted components of the traditional Chinese medicine is an important link in the traditional Chinese medicine production process, and most of domestic traditional Chinese medicine manufacturers at present completely rely on employee experience to carry out subjective control and adjustment of the extraction process, so that the quality of the product cannot be ensured, and the industrial development is not favored.
The traditional Chinese medicine has complex components, the quality of the production process is difficult to monitor in real time, the quality control is still carried out by adopting the end point detection standard of the production quality index in the traditional Chinese medicine production at present, and hysteresis exists. The process analysis technology is already applied to the online quality control of the traditional Chinese medicine, wherein the spectrum online analysis technology becomes an important research direction of the online quality analysis of the traditional Chinese medicine due to the rapid analysis speed, non-destructive property and wide sample detection range. In addition, because of different mechanisms and environments of the traditional Chinese medicine production working section, establishing an online detection system aiming at a specific production working section is a key for ensuring accurate analysis results.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine liquid component online detection and analysis system and a detection and analysis method capable of analyzing the medicine liquid component online in real time in the traditional Chinese medicine production process, so as to solve at least one technical problem in the background technology.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
In one aspect, the invention provides an on-line detection and analysis system for components of traditional Chinese medicine liquid, comprising:
the device comprises a liquid medicine sampling device, a filtering device, a bubble removing device, a constant temperature device and an on-line detection device;
the liquid medicine sampling device is provided with a bypass circulation path to extract liquid medicine to be detected from the traditional Chinese medicine extraction tank;
the filtering device is arranged in the liquid medicine sampling path and is used for filtering the extracted liquid medicine to be detected;
the defoaming device is connected with the filtering device and is used for defoaming the filtered liquid medicine to be tested;
the constant temperature device is connected to the periphery of the bubble removing device and is used for maintaining the temperature of the liquid medicine to be detected;
The on-line detection device is connected to the downstream of the bubble removal device and is used for carrying out component detection analysis on the constant-temperature to-be-detected liquid medicine subjected to filtering and bubble removal by utilizing the on-line spectrum detection system, and acquiring the component information of the liquid medicine in real time.
Preferably, the on-line detection device comprises a detection flow cell, a detection light source emitter, a detection light source receiver, a display screen, an optical fiber and a data analysis module, wherein the detection light source emitter emits a light source to be incident into the detection flow cell through the optical fiber, the light source emits after penetrating through the liquid medicine to be detected in the flow cell, the light source is received by the detection light source receiver through the optical fiber, detection spectrum data are generated and transmitted to the data analysis module for analysis, and real-time component information of the liquid medicine is obtained and displayed through the display screen.
Preferably, the front end and the rear end of the detection flow cell are respectively provided with a light source outlet and a light source inlet, the upper end and the lower end of the detection flow cell are respectively provided with a flow cell sample inlet and a flow cell sample outlet, the inside of the detection flow cell is provided with a sample guide channel, and the light source outlet and the light source inlet are respectively internally provided with an optical lens.
The liquid medicine sampling device comprises a traditional Chinese medicine extracting tank and a metering pump, wherein a sampling port is arranged at the bottom of the traditional Chinese medicine extracting tank, a sample return port is arranged at the top of the traditional Chinese medicine extracting tank, the sampling port is communicated with the detection flow cell, the detected liquid medicine returns to the traditional Chinese medicine extracting tank through the sample return port, the metering pump provides power for a bypass circulating system, and the flow controllable extraction of the liquid medicine is realized by controlling the power of the pump.
Preferably, the bubble removing device comprises a bubble removing liquid storage tank communicated with the metering pump, wherein the bottom of the bubble removing liquid storage tank is communicated with the detection flow cell, the top of the bubble removing liquid storage tank is communicated with the sampling port, and stirring blades are arranged in the bubble removing liquid storage tank.
Preferably, the filtering device comprises a first-stage filter screen arranged at the inner bottom of the traditional Chinese medicine extracting tank, a second-stage filter arranged on a pipeline between the metering pump and the sampling port, and a third-stage filter arranged on a pipeline between the metering pump and the defoaming liquid storage tank.
Preferably, the constant temperature device comprises an automatic temperature control module, a temperature sensor arranged in the bubble removal liquid storage tank, an electric heating structure arranged outside the bubble removal liquid storage tank and a heat preservation shell arranged outside the electric heating structure, wherein the temperature sensor acquires temperature information of liquid medicine in the bubble removal liquid storage tank in real time and sends the temperature information to the automatic temperature control module, and the automatic temperature control module controls the electric heating structure to be opened or closed according to the temperature information.
Preferably, a sampling valve and a third electromagnetic valve are sequentially arranged on a pipeline between the sampling port and the secondary filter, a first electromagnetic valve is arranged on a pipeline between the bubble removal liquid storage tank and the tertiary filter, a manual check valve and a fifth electromagnetic valve are arranged on a pipeline between the sample return port and the tertiary filter, a second electromagnetic valve is arranged on a pipeline between the detection flow cell and the metering pump, and a fourth electromagnetic valve is arranged on a pipeline between the bubble removal liquid storage tank and the detection flow cell.
The metering pump, the secondary filter, the tertiary filter, the bubble removal liquid storage tank and the detection flow cell are all arranged in a cabinet body, an indicator lamp, a display screen, a detection switch, a cabinet lock and an emergency stop button are arranged on a front door of the cabinet body, an off-line detection sampling port is arranged on the rear side of the cabinet body and communicated with the bubble removal liquid storage tank, a warning lamp is arranged at the top of the cabinet body, and a sample inlet and a sample outlet which are respectively connected with the sampling port and the sample return port are arranged on the cabinet body.
In a second aspect, the present invention provides a method for detecting and analyzing components of a liquid medicine by using the on-line detecting and analyzing system for components of a liquid medicine of traditional Chinese medicine, comprising:
The automatic temperature control module controls the electric heating structure to work, maintains the temperature of the liquid medicine in the bubble removing liquid storage tank at a determined detection temperature, opens the second electromagnetic valve and the fifth electromagnetic valve, opens the metering pump, enables the liquid medicine in the bubble removing liquid storage tank to flow downwards through the detection flow cell, closes the second electromagnetic valve and the metering pump, opens the detection switch, processes and analyzes the detected spectrum data through the data analysis system to obtain real-time component information of the liquid medicine, records the information, simultaneously displays the information through the display screen, opens the second electromagnetic valve after the on-line detection is completed, opens the metering pump, pumps the liquid medicine back to the extraction tank, and realizes bypass circulation.
The invention has the beneficial effects of realizing the on-line detection of the liquid medicine components in the traditional Chinese medicine extraction process, overcoming the hysteresis of the off-line detection of the traditional Chinese medicine quality, providing data support for realizing the real-time standard control of the traditional Chinese medicine production, improving the production process and improving the production efficiency.
Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a perspective view of a system for on-line detection and analysis of components of a Chinese medicinal liquid according to an embodiment of the present invention.
Fig. 2 is a rear view of a cabinet body of the on-line detection and analysis system for components of traditional Chinese medicine liquid according to the embodiment of the invention.
Fig. 3 is a schematic diagram of a pipeline structure of an on-line detection and analysis system for components of a traditional Chinese medicine liquid according to an embodiment of the invention.
Fig. 4 is a diagram of a traditional Chinese medicine extracting tank of an on-line detection and analysis system for traditional Chinese medicine liquid components according to an embodiment of the invention.
Fig. 5 is a diagram showing a structure of a bubble removal liquid storage tank of an on-line detection and analysis system for components of a traditional Chinese medicine liquid according to an embodiment of the present invention.
Fig. 6 is a schematic diagram of a detection flow cell of an on-line detection and analysis system for components of a traditional Chinese medicine liquid according to an embodiment of the present invention.
Fig. 7 is a sectional view of the internal structure of a detection flow cell of the on-line detection and analysis system for components of traditional Chinese medicine liquid according to the embodiment of the invention.
The device comprises a 1-sampling valve, a 2-secondary filter, a 3-detection flow cell, a 4-detection light source emitter, a 5-metering pump, a 6-detection light source receiver, a 7-warning lamp, an 8-bubble removing device, a 9-traditional Chinese medicine extracting tank, a 10-indicator lamp, a 11-display screen, a 12-detection switch, a 13-cabinet lock, a 14-emergency stop button, a 15-sample inlet, a 16-beaker, a 17-off-line detection sample inlet, a 18-sample outlet, a 19-first electromagnetic valve, a 20-exhaust valve, a 21-second electromagnetic valve, a 22-third electromagnetic valve, a 23-tertiary filter, a 24-fourth electromagnetic valve, a 25-manual check valve, a 26-fifth electromagnetic valve, a 27-pressure gauge, a 28-sample inlet, a 29-primary filter screen, a 30-sample return inlet, a 31-stirring blade, a 32-insulation shell, a 33-electric heating structure, a 34-bubble removing tank, a 35-micropore, a 36-light path channel, a 37-flange, a 38-light source outlet, a 39-sample guide channel, a 40-sample inlet, a 41-optical cell outlet, a 42-optical lens inlet and a 43-light source flow cell.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements throughout or elements having like or similar functionality. The embodiments described below by way of the drawings are exemplary only and should not be construed as limiting the invention.
It will be understood by those skilled in the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless expressly stated otherwise, as understood by those skilled in the art. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, and/or groups thereof.
In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.
In order that the invention may be readily understood, a further description of the invention will be rendered by reference to specific embodiments that are illustrated in the appended drawings and are not to be construed as limiting embodiments of the invention.
It will be appreciated by those skilled in the art that the drawings are merely schematic representations of examples and that the elements of the drawings are not necessarily required to practice the invention.
Example 1
As shown in fig. 1 to 7, embodiment 1 of the present invention provides an on-line detection and analysis system for components of a traditional Chinese medicine liquid, the system comprising:
the device comprises a liquid medicine sampling device, a filtering device, a bubble removing device, a constant temperature device and an on-line detection device;
the liquid medicine sampling device is provided with a bypass circulation path to extract liquid medicine to be detected from the traditional Chinese medicine extraction tank;
the filtering device is arranged in the liquid medicine sampling path and is used for filtering the extracted liquid medicine to be detected;
the defoaming device is connected with the filtering device and is used for defoaming the filtered liquid medicine to be tested;
the constant temperature device is connected to the periphery of the bubble removing device and is used for maintaining the temperature of the liquid medicine to be detected;
The on-line detection device is connected to the downstream of the bubble removal device and is used for carrying out component detection analysis on the constant-temperature to-be-detected liquid medicine subjected to filtering and bubble removal by utilizing the on-line spectrum detection system, and acquiring the component information of the liquid medicine in real time.
In this embodiment 1, the on-line detection device includes a detection flow cell 3, a detection light source emitter 4, a detection light source receiver 6, a display screen 11, an optical fiber and a data analysis module, where the detection light source emitter 4 emits a light source to be incident on the detection flow cell 3 through the optical fiber, the light source is transmitted through the liquid medicine to be detected in the detection flow cell 3 and then emitted, and is received by the detection light source receiver 6 through the optical fiber, so as to generate detection spectrum data, and the detection spectrum data is transmitted to the data analysis module for analysis, so as to obtain real-time component information of the liquid medicine, and the real-time component information is displayed through the display screen 11.
In this embodiment 1, the front and rear ends of the detection flow cell 3 are respectively provided with a light source outlet 38 and a light source inlet 42, the upper part of the detection flow cell 3 is provided with a flow cell sample inlet 43, the lower part of the detection flow cell 3 is provided with a flow cell sample outlet 40, the middle part of the detection flow cell 3 is provided with a sample inlet micropore 35 and a light path channel 36, the inside of the detection flow cell 3 is provided with a sample guide channel 39, the light source outlet 38 and the light source inlet 42 are respectively provided with a lens 41, and the upper and lower parts of the detection flow cell 3 are respectively provided with a flange structure 37.
In the embodiment 1, the liquid medicine sampling device comprises a traditional Chinese medicine extracting tank 9 and a metering pump 5, wherein a sampling port 28 is arranged at the bottom of the traditional Chinese medicine extracting tank 9, a sample return port 30 is arranged at the top of the traditional Chinese medicine extracting tank 9, the sampling port 28 is communicated with the detection flow cell 3, the detected liquid medicine returns to the traditional Chinese medicine extracting tank 9 through the sample return port 30, the metering pump provides power for a bypass circulating system, and the flow controllable extraction of the liquid medicine is realized by controlling the pump power.
The bubble removing device comprises a bubble removing liquid storage tank 34 communicated with the metering pump 5, wherein the bottom of the bubble removing liquid storage tank 34 is communicated with the detection flow cell 3, the top of the bubble removing liquid storage tank 34 is communicated with the sampling port 30, and stirring blades 31 are arranged in the bubble removing liquid storage tank 34.
The filtering device comprises a first-stage filter screen 29 arranged at the inner bottom of the traditional Chinese medicine extracting tank 9, a second-stage filter 2 arranged on a pipeline between the metering pump 5 and the sampling port 28, and a third-stage filter 23 arranged on a pipeline between the metering pump 5 and the defoaming liquid storage tank 34.
The constant temperature device comprises an automatic temperature control module, a temperature sensor arranged in the bubble removal liquid storage tank 34, an electric heating structure 33 arranged outside the bubble removal liquid storage tank 34 and a heat preservation shell 32 arranged outside the electric heating structure 33, wherein the temperature sensor acquires temperature information of liquid medicine in the bubble removal liquid storage tank 34 in real time and sends the temperature information to the automatic temperature control module, and the automatic temperature control module controls the electric heating structure 33 to be opened or closed according to the temperature information.
A sampling valve 1 and a third electromagnetic valve 22 are sequentially arranged on a pipeline between the sampling port 28 and the secondary filter 2, a first electromagnetic valve 19 is arranged on a pipeline between the bubble removal liquid storage tank 34 and the tertiary filter 23, a manual check valve 25 is arranged on a pipeline between the sample return port 30 and the tertiary filter 23, a second electromagnetic valve 21 is arranged on a pipeline between the detection flow cell 3 and the secondary filter 2, a fourth electromagnetic valve 24 is arranged on a pipeline between the bubble removal liquid storage tank 34 and the detection flow cell 3, and a fifth electromagnetic valve 26 is arranged on a pipeline between the manual check valve 25 and the sample return port 30.
The metering pump 5, the secondary filter 2, the tertiary filter 23, the bubble removal liquid storage tank 34 and the detection flow cell 3 are all arranged in a cabinet body, an indicator lamp 10, a display screen 11, a detection switch 12, a cabinet lock 13 and an emergency stop button 14 are arranged on a front door of the cabinet body, a warning lamp 7 is arranged at the top of the cabinet body, and a sample inlet 15 and a sample outlet 18 which are respectively connected with the sampling port 28 and the sample return port 30 are arranged on the cabinet body.
In this embodiment 1, the method for detecting and analyzing the components of the liquid medicine by using the on-line detecting and analyzing system for components of the liquid medicine of traditional Chinese medicine as described above comprises the following steps:
The automatic temperature control module controls the electric heating structure to work, maintains the temperature of the liquid medicine in the bubble removing liquid storage tank at a determined detection temperature, opens the second electromagnetic valve and the fifth electromagnetic valve, opens the metering pump, enables the liquid medicine in the bubble removing liquid storage tank to flow downwards through the detection flow cell, closes the second electromagnetic valve and the metering pump, opens the detection switch, processes and analyzes the detected spectrum data through the data analysis system to obtain real-time component information of the liquid medicine, records the information, simultaneously displays the information through the display screen, opens the second electromagnetic valve after the on-line detection is completed, opens the metering pump, pumps the liquid medicine back to the extraction tank, and realizes bypass circulation.
Example 2
As shown in fig. 1 to 7, embodiment 2 of the present invention provides an on-line detection system for liquid medicine components in a process of extracting traditional Chinese medicine, comprising:
the device comprises a liquid medicine sampling device, a filtering device, a bubble removing device, a constant temperature device and an on-line detection device;
the liquid medicine sampling device is provided with a bypass circulation path to extract liquid medicine to be detected from the traditional Chinese medicine extracting tank 9;
The filtering device is arranged in the liquid medicine sampling path and adopts a three-stage filtering mode to filter solid impurities such as dregs and suspended matters in the liquid medicine;
the constant temperature device is arranged at the periphery of the bubble removing system, and an automatic temperature control system is used for maintaining the liquid medicine to be detected at the determined detection temperature;
The on-line detection device is arranged behind the defoaming system, the on-line spectrum detection system is utilized to carry out component detection analysis on the filtered and defoamed constant-temperature liquid medicine, real-time component information of the liquid medicine is obtained through analysis, and the completion time of liquid medicine extraction can be judged according to the component curve change trend.
The liquid medicine sampling device builds a bypass circulation detection path, and provides power for the metering pump 5 to realize controllable extraction of the flow of the traditional Chinese medicine liquid. The bypass circulation detection path comprises an online detection path and a bypass circulation path, the switching is coordinated and controlled by electromagnetic valves (a first electromagnetic valve 19, a second electromagnetic valve 21, a third electromagnetic valve 22, a fourth electromagnetic valve 24 and a fifth electromagnetic valve 26) arranged in the paths, and a manual check valve 25 is arranged in a pipeline to realize the flow of the liquid medicine according to the direction of the specified path.
The filtering device adopts a three-stage filtering mode to filter impurities in the liquid medicine, a first-stage filter screen 29 is arranged at the bottom of the tank of the traditional Chinese medicine extraction tank, the two-stage filter 2 and the three-stage filter 23 are arranged in a bypass circulation path and are respectively positioned in front of and behind the metering pump, and the optimal filtering effect can be achieved by adopting the three-stage filtering mode.
The two-stage filter 2 and the three-stage filter 23 can replace filter elements with different meshes to cope with different filtering conditions. The filter elements with different filtering precision are selected and used, so that the filtering requirements of different liquid medicines are met, the filter elements can be disassembled and cleaned, and the filter elements can be reused, so that the hidden danger of bypass blockage is avoided.
The bubble removing device comprises a bubble removing liquid storage tank 34 and stirring blades 31 arranged in the liquid storage tank, wherein special inclined structures are arranged at the upper part and the bottom of the tank body and are respectively used for preventing secondary bubbles of liquid medicine from being generated and guaranteeing the liquid medicine to flow completely, the stirring blades 31 are arranged in the liquid storage tank and are used for stirring the liquid medicine to obtain uniform liquid, bubbles in the liquid medicine move upwards to the surface of the liquid, gas is discharged from an exhaust valve 20 above after the bubbles are broken, and bubble-free liquid medicine is positioned at the bottom of the liquid storage tank for subsequent detection, so that bubble removing treatment is realized.
The constant temperature device comprises an electric heating structure, a heat preservation device and an automatic temperature control system, wherein the electric heating structure 33 is arranged on the periphery of the bubble removal liquid storage tank 34 and used for maintaining the temperature of liquid medicine in the liquid storage tank at a determined detection temperature, and the heat preservation device is arranged outside a pipeline between the liquid storage tank and the detection flow cell for heat preservation.
The electric heating structure 33 is controlled by an automatic temperature control system, a temperature sensor is arranged in the traditional Chinese medicine extracting tank to detect the temperature of liquid in the tank, and the temperature control system automatically controls the electric heating device (the electric heating structure 33) to work according to the actually detected liquid temperature.
The on-line detection device comprises a detection light source emitter 4, a detection light source receiver 6, a detection flow cell 3, a display screen 11, an optical fiber and a data analysis system, wherein the detection flow cell 3 is arranged below the bubble removal device, front and rear interfaces of the flow cell are respectively connected with the detection light source emitter 4 and the detection light source receiver 6 through the optical fiber, upper and lower interfaces are respectively connected with sample injection and sample discharge pipes, the detection light source is received again after penetrating through the liquid medicine in the flow cell, on-line spectrum detection data of the liquid medicine are formed, the data are transmitted to the data analysis system for analysis, real-time component information of the liquid medicine is obtained and recorded, and meanwhile, the display screen is used for displaying.
The detection space inside the detection flow cell 3 is formed by sealing optical lenses 41 at two ends, the sealed detection space can eliminate redundant interference of environmental factors, a fine light path channel is arranged in the middle of the flow cell for detection light to pass through, and a fine inclined pore channel structure (namely a sample guide channel 39) is arranged inside the detection flow cell, so that the flow rate of liquid medicine can be stabilized, and the state of the liquid medicine is kept uniform.
The flange structure that detects the upper and lower end of flow cell was equipped with is used for the fixed of flow cell, and interface and liquid medicine business turn over pipeline connection about the flow cell, and the inside special enclosure space of flow cell can stabilize the liquid medicine velocity of flow, makes it keep continuous even state, improves on-line measuring accuracy and stability.
The on-line detection device adopts a four-way parallel detection mode, and detection data among different ways form full comparison analysis. That is, two bubble removal liquid tanks 34 are included in total, and each bubble removal liquid tank 34 communicates with two detection flow cells 3. The liquid medicine is conveyed into two bubble removing liquid storage tanks, and the lower part of each bubble removing liquid storage tank is divided into two paths for detection, so that sufficient contrast detection analysis is formed, and the detection result is more accurate and stable.
The back cover of the cabinet body of the online detection device is provided with an offline detection sampling port 17, and the beaker 16 can be used for sampling the liquid medicine to be detected for offline analysis.
In this embodiment 2, the on-line detection device is connected to the traditional Chinese medicine extraction tank 9, the electromagnetic valves and metering pumps are coordinated to operate, the liquid medicine is extracted from the extraction tank, filtered and pumped into the defoaming liquid storage tank, stirring blades in the liquid storage tank stir to make the liquid medicine uniform, bubbles in the liquid medicine float upwards and break to complete defoaming treatment, the automatic temperature control system controls the electric heating device to operate, the temperature of the liquid medicine in the liquid storage tank is maintained at a determined detection temperature, the on-line detection system is started to detect the constant-temperature liquid medicine filtered and defoamed, the detected spectral data is processed and analyzed by the data analysis system to obtain real-time component information of the liquid medicine and recorded, and simultaneously, the on-line detection is performed through the display screen, the off-line detection electromagnetic valve (namely, the fourth electromagnetic valve 24) is started to sample, the sample liquid is used for off-line detection analysis, the analysis result can be used for correcting an on-line detection model of the liquid medicine, the liquid medicine after on-line detection is pumped back to the extraction tank again to realize bypass circulation, the steps are repeated to detect, the analysis results are counted to form a liquid medicine component change curve, and the time of the completion of traditional Chinese medicine extraction is accurately judged according to the change trend of curve.
Example 3
As shown in fig. 1, embodiment 3 of the present invention provides an on-line detection device for liquid medicine components in a traditional Chinese medicine extraction process, which comprises a liquid medicine sampling system, a filtering system, a defoaming system, a constant temperature system and an on-line detection system. The device of this embodiment 3 adopts a bypass circulation sampling mode to perform on-line detection of the liquid medicine component in the process of extracting the traditional Chinese medicine.
Specifically, the bottom in the traditional chinese medicine draws jar 9 jar is provided with one-level filter equipment (i.e. one-level filter screen 29) and filters the dregs of a decoction, traditional chinese medicine draws jar 9 below sampling port 28 and sets up sample valve 1, link to each other with third solenoid valve 22 through nonrust steel pipe, both control liquid medicine advances the appearance simultaneously, metering pump 5 provides power for whole bypass circulation system, two grade filter 2 and tertiary filter 23 set up respectively around the metering pump, every bubble removal device 8 below tapping two detection flow cells constitutes four-way parallel on-line measuring, bubble removal device bottom sets up off-line detection sampling port 17 simultaneously, be controlled by fourth solenoid valve 24 and open and close, beaker 16 is used for receiving the sample liquid.
The front cover of the cabinet body of the online detection device is provided with an indicator lamp 10 for indicating the detection state, a detection switch 12 is used for controlling the detection to be opened and closed, an emergency stop button 14 is arranged for coping with emergency, the front cover is also provided with a display screen 11 for displaying detection information in real time, and a warning lamp 7 is arranged above the detection device for generating a warning signal.
As shown in fig. 3, the bypass circulation on-line detection system comprises an on-line detection path and a bypass circulation path, the switching is controlled by the first electromagnetic valve 19, the second electromagnetic valve 21, the third electromagnetic valve 22 and the fifth electromagnetic valve 26 at the same time, and a check valve 25 is arranged in a pipeline to realize the flow of the liquid medicine according to the direction of the prescribed path.
As shown in fig. 4, a sampling port 28 is arranged below the traditional Chinese medicine extracting tank, a sample return port 30 is arranged above the traditional Chinese medicine extracting tank to receive the detected sample return liquid medicine and realize circulation, and a pressure gauge 27 is further arranged above the extracting tank to detect the pressure in the tank.
As shown in fig. 5, an electric heating device 33 is arranged outside a bubble removal liquid storage tank 34 in the bubble removal device, stirring blades 31 are arranged inside the bubble removal device, and a heat preservation shell 32 is arranged at the outermost periphery of the bubble removal device.
As shown in fig. 6 and 7, the upper and lower ends of the detection flow cell are provided with flange structures 37, the front and rear sides of the flow cell are respectively provided with a light source outlet 38 and a light source inlet 42, the upper and lower sides of the flow cell are respectively provided with a flow cell sample inlet 43 and a sample outlet 40, and a special inclined sample guiding path 39 is arranged in the flow cell for stabilizing the flow rate of the liquid medicine.
In this embodiment, the medical fluid sampling system may select different devices according to actual requirements. The sampling system is preferably a 100L miniature traditional Chinese medicine extraction tank, the sampling pipeline is preferably a 4-branch pipe made of 304 stainless steel, the type selection of a metering pump needs to meet the requirement of providing enough pressure to realize the bypass circulation of the detection liquid medicine, a metering pump and an electromagnetic valve used in the sampling system are controlled by a controller in a coordinated manner, the running power of the pump can be adjusted according to actual conditions, and the electromagnetic valve is kept in a closed state when not working.
In the filtering system in this embodiment 3, the bottom of the tank of the traditional Chinese medicine extracting tank 9 is preferably an 80-mesh primary filter screen, the secondary filter is preferably a 10-micron pore filter element, the tertiary filter is preferably a 1-micron pore filter element, and the tertiary filtering mode can achieve a sufficient filtering effect and remove the interference of impurities on the detection of the liquid medicine. The filter screen and the filter core that this filtration system selected for use are stainless steel, easily unpick and wash, prevent that the pipeline from blocking.
The bubble removing system and the constant temperature system are combined, the electric heating device (namely the electric heating structure) surrounds the bubble removing liquid storage tank, the liquid medicine in the bubble removing liquid storage tank 34 is uniformly heated, the temperature of the liquid medicine is maintained at the determined detection temperature, stirring blades are arranged in the bubble removing liquid storage tank to stir, the liquid is uniformly heated while the uniform liquid medicine is obtained, bubbles in the liquid medicine float to the surface of the liquid to be broken, and the gas is discharged from the exhaust valve 20 above the liquid storage tank.
The on-line detection system consists of a detection flow cell 3, a detection light source emitter 4, a detection light source receiver 6, a display screen 11, an optical fiber and a data analysis system. The liquid medicine enters from the upper end of the detection flow cell, and passes through a special space inside the flow cell to form a stable and uniform state, the light source emitted by the detection light source emitter 4 enters from the rear end of the detection flow cell 3 through optical fibers, the light source penetrates through the liquid medicine in the flow cell and then is emitted from the front end, the light source is received by the detection light source receiver 6 through the optical fibers, detection spectrum data are generated and transmitted to the data analysis system for analysis, real-time component information of the liquid medicine is obtained, the real-time component information is displayed through the display screen, and the function of online detection of the liquid medicine components in the traditional Chinese medicine extraction process is realized.
The devices such as the guide pipe, the battery valve, the filter, the metering pump, the liquid storage tank, the flow cell and the like related to the whole bypass circulation path are all made of stainless steel materials, and the application materials reach food grade, so that the device is suitable for the production requirements of traditional Chinese medicines.
The upper part of the defoaming liquid storage tank body is provided with an inclined structure (inclined wall), and liquid medicine entering from the upper sample inlet flows into the liquid storage tank along the inclined wall and the vertical wall successively, so that the generation of liquid medicine secondary bubbles is prevented. The bottom of the liquid storage tank is also provided with an inclined structure, can ensure the liquid medicine to flow completely and avoid accumulation.
The electric heating device is controlled by an automatic temperature control system, a temperature sensor is arranged in the bubble removal liquid storage tank 34 to detect the temperature of liquid in the tank, the temperature control system automatically controls the electric heating device (the electric heating structure 33) to work according to the actually detected liquid temperature, the liquid medicine temperature in the bubble removal liquid storage tank 34 is maintained at the determined detection temperature, in addition, the periphery of a liquid medicine conduit between the liquid storage tank and the detection flow cell is wrapped with a heat preservation sponge to preserve heat, and the influence of temperature change on liquid medicine detection is removed.
The detection space inside the detection flow cell is formed by closing optical lenses 41 at two ends, a small light path channel 36 is arranged in the middle for the detection light to pass through, and the closed detection space can eliminate the interference of redundant environmental factors. In addition, a fine inclined pore canal structure (sample guide channel 39) is arranged in the detection flow cell, so that the communication between the flow cell sample inlet 43, the flow cell sample outlet 40 and the detection space is realized, the flow rate of the liquid medicine can be stabilized by the inclined pore canal structure, the liquid medicine state is kept uniform, and the accuracy and the stability of the on-line detection are improved.
The on-line detection system adopts a four-way parallel detection mode, detection data among different ways form full contrast analysis, and the final detection result takes the average value of the detection results of all ways, so that the accuracy and the stability of on-line detection are further improved. The back cover of the online detection device is provided with an offline detection sampling port, the fourth electromagnetic valve 24 can be opened to sample a certain amount of liquid medicine to be detected for offline analysis, and the analysis result can be used for correcting and updating the liquid medicine online detection model.
In this embodiment 3, the working method of the device for detecting the components of the liquid medicine in the extraction process of the traditional Chinese medicine on line specifically includes the following steps:
The on-line detection device is connected with the traditional Chinese medicine extracting tank through a conduit, the extracting tank starts to work after medicinal materials and solvents are added, the sampling valve 1, the third electromagnetic valve 22 and the first electromagnetic valve 19 are opened, the controller controls the metering pump 5 to work according to certain power, the medicinal liquid is pumped into the bubble removing liquid storage tank 34 after being filtered, after the medicinal liquid in the bubble removing liquid storage tank 34 reaches a certain liquid level, the third electromagnetic valve, the first electromagnetic valve and the metering pump are closed, stirring blades in the liquid storage tank stir the medicinal liquid uniformly, and bubbles in the medicinal liquid float upwards and are crushed to finish bubble removing treatment.
The automatic temperature control system controls the electric heating device to work, maintains the temperature of the liquid medicine in the bubble removal liquid storage tank 34 at a determined detection temperature, opens the second electromagnetic valve 21 and the fifth electromagnetic valve 26, controls the metering pump 5 to work according to smaller power, the liquid medicine in the bubble removal liquid storage tank 34 flows downwards through the detection flow cell 3, closes the second electromagnetic valve and the metering pump, opens the detection switch 12 on the front cover to enable the detection system to start working, and the detected spectrum data is processed and analyzed by the data analysis system to obtain and record the real-time component information of the liquid medicine and is displayed through the display screen.
The method comprises the steps of carrying out on-line detection, opening an off-line detection fourth electromagnetic valve 24 to sample liquid, opening a second electromagnetic valve after the on-line detection is finished, opening a metering pump, pumping liquid medicine back to an extraction tank to realize bypass circulation, opening a third electromagnetic valve 22 after the liquid medicine in the liquid storage tank is completely pumped, closing a second electromagnetic valve 21, regulating the metering pump 5 to work with original power, extracting the liquid medicine from a traditional Chinese medicine extraction tank 9 to carry out bypass circulation for a certain time, removing the residual liquid medicine detected last time in a conduit, repeating the operation to carry out subsequent detection, counting analysis results of each time to form a liquid medicine component change curve according to actual detection requirements, and accurately judging the time of traditional Chinese medicine extraction completion according to curve change trend, thereby effectively improving the production efficiency of traditional Chinese medicines.
In summary, the on-line detection and analysis system for components of traditional Chinese medicine liquid according to the embodiment of the invention comprises a liquid sampling device, a filtering device, a bubble removing device, a constant temperature device and an on-line detection device, wherein a bypass circulation path is built in the liquid sampling device to extract liquid to be detected from a traditional Chinese medicine extraction tank, the filtering device is arranged in the liquid sampling path to filter solid impurities in the liquid in a three-stage filtering mode, the bubble removing device is arranged behind the filtering device to remove bubbles from the sampled liquid to be detected, the constant temperature device is arranged on the periphery of the bubble removing device to maintain the liquid to be detected at a determined detection temperature by using an automatic temperature control system, the on-line detection device is arranged behind the bubble removing device to perform component detection and analysis on the filtered and bubble removed constant temperature liquid by using the on-line spectrum detection system to analyze real-time component information of the liquid to obtain the liquid, and the completion time of liquid extraction can be judged according to component curve change trend.
The on-line detection and analysis system for the liquid medicine components in the traditional Chinese medicine extraction process provided by the embodiment of the invention realizes on-line detection of the liquid medicine components in the traditional Chinese medicine extraction process, overcomes the hysteresis of the existing off-line detection of the quality of traditional Chinese medicines, provides data support for realizing real-time standard control of traditional Chinese medicine production, improves the original subjective control method according to experience, and improves the production efficiency. The automatic analysis of the traditional Chinese medicine extraction process is realized, the informatization and the automation of the whole traditional Chinese medicine production process are promoted, the process understanding is improved, the production process is improved, the difference between medicines in different production batches is reduced, and the quality is stable and uniform. The method is suitable for on-line detection of traditional Chinese medicine extraction of different medicinal materials in different environments, has low requirements on transformation of traditional Chinese medicine extraction tanks, and is suitable for industrialized popularization.
The foregoing description of the preferred embodiments of the present disclosure is provided only and not intended to limit the disclosure so that various modifications and changes may be made to the present disclosure by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present disclosure should be included in the protection scope of the present disclosure.
While the foregoing embodiments of the present disclosure have been described in conjunction with the accompanying drawings, it is not intended to limit the scope of the disclosure, and it should be understood that, based on the technical solutions disclosed in the present disclosure, various modifications or variations may be made by those skilled in the art without requiring any inventive effort, and are intended to be included in the scope of the present disclosure.
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