CN112415774A - Design method of corneal contact lens - Google Patents
Design method of corneal contact lens Download PDFInfo
- Publication number
- CN112415774A CN112415774A CN202011464484.7A CN202011464484A CN112415774A CN 112415774 A CN112415774 A CN 112415774A CN 202011464484 A CN202011464484 A CN 202011464484A CN 112415774 A CN112415774 A CN 112415774A
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- wavefront
- aberration
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- corneal
- cornea
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- 238000000034 method Methods 0.000 title claims abstract description 14
- 230000004075 alteration Effects 0.000 claims abstract description 66
- 210000004087 cornea Anatomy 0.000 claims abstract description 25
- 238000007493 shaping process Methods 0.000 claims abstract description 4
- 238000003384 imaging method Methods 0.000 claims description 4
- 238000000342 Monte Carlo simulation Methods 0.000 claims description 3
- 238000003491 array Methods 0.000 claims description 3
- 238000000354 decomposition reaction Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 230000011218 segmentation Effects 0.000 claims description 3
- 238000004088 simulation Methods 0.000 claims description 3
- 210000000695 crystalline len Anatomy 0.000 description 23
- 230000003287 optical effect Effects 0.000 description 7
- 201000009310 astigmatism Diseases 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 230000004379 myopia Effects 0.000 description 3
- 208000001491 myopia Diseases 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 210000001525 retina Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 206010002945 Aphakia Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 241000219793 Trifolium Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004402 high myopia Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 208000014733 refractive error Diseases 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/024—Methods of designing ophthalmic lenses
- G02C7/027—Methods of designing ophthalmic lenses considering wearer's parameters
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/024—Methods of designing ophthalmic lenses
- G02C7/028—Special mathematical design techniques
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
Abstract
The invention discloses a design method of a corneal contact lens, which is characterized by comprising the following steps: measuring data of the corneal surface; calculating a corneal wavefront distribution and corresponding wavefront aberrations; measuring the wavefront aberration data of the whole eye and reconstructing the wavefront aberration of the whole eye; calculating an intraocular aberration; constructing a three-dimensional wavefront model; selecting an optimal array combination; designing the micro-lens structure of the corresponding area of the corneal contact lens, enabling the light wave to form a corresponding waveform in the area after passing through the corneal shaping lens and the cornea, and outputting the distribution of the micro-lens structure as a final result.
Description
Technical Field
The invention relates to a design method of a corneal contact lens, belonging to the technical field of corneal contact lenses.
Background
The Contact Lens (CL) is directly attached to the lacrimal fluid layer of the cornea, is compatible with the physiology of human eyes, and achieves the purpose of vision correction. Compared with orbital frame glasses, CL has a larger visual field, can keep optical correction performance in all watching directions, eliminates the prism effect of the glasses, eliminates oblique astigmatism, reduces retina aberration of eyes, keeps better binocular vision, is safe, convenient and attractive to use, and also has some special lenses which can meet some special requirements. Indications are as follows: is especially suitable for high myopia, corneal astigmatism, refractive error, aphakic eye, etc.
The curved surface formed by the equiphase surface when the light is transmitted to a certain position is called wavefront, however, because the human eye is an imperfect optical system, such as the non-uniform of the axis of the eye and the optical axis, the non-uniform of the density of the crystalline lens, the irregular surface of the cornea and the like, the deviation of the wavefront entering or exiting the human eye can be caused, and the deviation between the ideal wavefront and the actual wavefront is called wavefront aberration. Wavefront aberrations are decomposed according to zernike polynomials and can be divided into lower order aberrations and higher order aberrations. The low-order aberration comprises optical parameters commonly used in the traditional optometry field, such as defocus and astigmatism; the high-order aberration comprises more complex optical changes of morphological contents such as coma aberration, clover astigmatism and the like. See fig. 2.
The Hartmann-Shack wavefront aberration measuring system can accurately detect all aberrations of the whole eye to obtain a compensation value for correcting the aberrations of the human eye, thereby reversely deducing the design of the corneal contact lens which can be used for compensating the aberrations.
Disclosure of Invention
The invention aims to solve the technical problem that the existing corneal contact lens can only solve the problems that the basic parameters such as diopter, astigmatism and the like and the actual high-order aberration in eyes cannot be compensated.
In order to solve the technical problems, the technical scheme of the invention is to provide a design method of a corneal contact lens, which obtains the intraocular aberration to be compensated by accurately measuring the whole-eye aberration and the corneal aberration (figure 3, the wave aberration is expressed by a Zernike polynomial to measure the aberration), and establishes a waveform segmentation array of the corneal contact lens and the corneal surface aberration to be compensated by using a Monte Carlo reverse reconstruction mode, thereby designing a micro-lens compensation scheme of local waveforms and effectively improving the visual quality; the method comprises the following specific steps: a method for designing a corneal contact lens, comprising the steps of:
measuring data of a cornea surface, measuring to obtain a cornea terrain, performing noise filtering on three-dimensional discrete point cloud of the cornea front surface in a three-dimensional coordinate system, performing zernike expression fitting, and recording the cornea front surface as W1(r, theta) along a light ray emergence direction;
step two, calculating the corneal wavefront distribution and corresponding wavefront aberration according to a ray tracing method, and recording as Z1(r, theta) after zernike decomposition;
measuring the wavefront data of the whole eye, measuring the wavefront data of an array of fundus focusing light spots by a Hartmann-Shack wavefront aberration measuring instrument, and reconstructing the wavefront aberration of the whole eye by using modal wavefront estimation of a zernike polynomial, wherein the wavefront aberration is recorded as Z2(r, theta);
and step four, subtracting the aberration of the whole eye aberration and the aberration of the cornea front surface to obtain the intraocular aberration which is recorded as
Z3(r，θ)＝Z2(r，θ)-Z1(r，θ)；
Step five, the corneal contact lens acts on the cornea and is regarded as a whole, and the intraocular aberration Z3(r, theta) is compensated, namely the sum of the corneal contact lens and the corneal aberration is-Z3 (r, theta);
constructing a three-dimensional wavefront model, dividing the three-dimensional wavefront model into n × n wavefront arrays as variables, performing simulation by a Monte Carlo method, and performing ray tracing to obtain an aberration value of-Z3 (r, theta);
step seven, selecting an optimal array combination to obtain each waveform of the n ^2 segmentation areas, and recording the waveform as Pi (r, theta), (i ^ 1,2, …, n ^ 2);
step eight, designing the micro-lens structure of the corresponding area of the corneal contact lens, enabling the light wave to form a corresponding waveform in the area after passing through the corneal shaping lens and the cornea, and outputting the distribution of the micro-lens structure as a final result.
In the first step, the surface data can be acquired by a corneal topographer, a Scheimpflug principle or an OCT principle three-dimensional imaging device.
The scheme of the invention has the advantages that:
1. the corneal contact lens can compensate high-order aberration, optimize local structure design and flexibly compensate all aberrations.
2. The micro-lens structure adopted on the surface of the corneal contact lens can be integrally consistent or independent, and can converge the imaging position of the edge to the front of the retina, thereby being beneficial to myopia prevention and control and delaying the increase of the axis of the eye.
Drawings
FIG. 1 is a schematic view of a corneal contact lens compensating for aberrations;
FIG. 2 is a schematic diagram of the self-contained aberration of an eye;
FIG. 3a is a wavefront aberration diagram for measuring intraocular aberrations;
FIG. 3b is a graph of various low and high order aberrations expressed using Zernike polynomials;
FIG. 4a is a two-dimensional schematic view of a segmented wavefront according to the present invention;
FIG. 4b is a three-dimensional schematic view of a segmented wavefront according to the present invention;
FIG. 5 is a schematic diagram of a sample distribution of output microlens designs for compensating aberrations;
FIG. 6 is a wave aberration diagram after compensating for aberrations;
fig. 7 is a schematic view of light rays for myopia prevention and control.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that it would be obvious to those skilled in the art that various changes and modifications can be made without departing from the spirit of the invention. All falling within the scope of the present invention.
The implementation method comprises the following steps:
the method comprises the following implementation steps:
1. measuring the data of the surface of the cornea, measuring to obtain the topography of the cornea, carrying out noise filtering on three-dimensional discrete point cloud of the front surface of the cornea in a three-dimensional coordinate system, carrying out zernike expression fitting, and marking the front surface of the cornea as W1(r, theta) along the light emergent direction;
the surface data can be acquired by a cornea topographer, a Scheimpflug principle or an OCT principle three-dimensional imaging device;
2. calculating the distribution of corneal wave front and corresponding wave front aberration according to ray tracing method, and recording as Z1(r, theta) after zernike decomposition;
3. measuring the wavefront aberration data of the whole eye, measuring the wavefront data of an array of fundus focusing light spots by a Hartmann-Shack wavefront aberration measuring instrument, and reconstructing the wavefront aberration of the whole eye by using modal wavefront estimation of zernike polynomials, wherein the wavefront aberration is recorded as Z2(r, theta);
4. the subtraction of the aberration of the anterior surface of the cornea from the aberration of the whole eye gives the intraocular aberration, which is recorded as
Z3(r，θ)＝Z2(r，θ)-Z1(r，θ)；
5. The contact lens acts with the cornea and is considered as a whole to compensate the intraocular aberration Z3(r, theta), namely the sum of the contact lens and the corneal aberration is-Z3 (r, theta);
6. constructing a three-dimensional wavefront model, dividing the three-dimensional wavefront model into n × n wavefront arrays as variables, performing simulation by a Monte Carlo method, and performing ray tracing to obtain an aberration value of-Z3 (r, theta);
7. the optimal array combination is chosen to obtain each waveform of n ^2 segmented areas, denoted as Pi (r, theta), (i ^ 1,2, …, n ^2), as shown in FIG. 4.
8. Designing the micro-lens structure of the corresponding area of the corneal contact lens, so that the light wave forms a corresponding waveform in the area after passing through the corneal shaping lens and the cornea, and outputting the distribution of the micro-lens structure as a final result, as shown in fig. 5.
The total eye aberration was tested after compensation to verify the effect, as shown in figure 6.
The local configuration may be selected by first performing an overall planning layout, such as a contact lens for myopia prevention and control that requires a step-wise asymptotic curvature that is set according to the optical curvature of the vitreous of the individual's eye such that the optical focus of the peripheral forward defocus region is located on the peripheral retina, as shown in fig. 7.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.
Claims (2)
1. A method for designing a corneal contact lens, comprising the steps of:
measuring data of a cornea surface, measuring to obtain a cornea terrain, performing noise filtering on three-dimensional discrete point cloud of the cornea front surface in a three-dimensional coordinate system, performing zernike expression fitting, and recording the cornea front surface as W1(r, theta) along a light ray emergence direction;
step two, calculating the corneal wavefront distribution and corresponding wavefront aberration according to a ray tracing method, and recording as Z1(r, theta) after zernike decomposition;
measuring the wavefront data of the whole eye, measuring the wavefront data of an array of fundus focusing light spots by a Hartmann-Shack wavefront aberration measuring instrument, and reconstructing the wavefront aberration of the whole eye by using modal wavefront estimation of a zernike polynomial, wherein the wavefront aberration is recorded as Z2(r, theta);
step four, subtracting the aberration of the cornea front surface from the aberration of the whole eye to obtain the intraocular aberration, which is recorded as Z3(r, theta) ═ Z2(r, theta) -Z1(r, theta);
step five, the corneal contact lens acts on the cornea and is regarded as a whole, and the intraocular aberration Z3(r, theta) is compensated, namely the sum of the corneal contact lens and the corneal aberration is-Z3 (r, theta);
constructing a three-dimensional wavefront model, dividing the three-dimensional wavefront model into n × n wavefront arrays as variables, performing simulation by a Monte Carlo method, and performing ray tracing to obtain an aberration value of-Z3 (r, theta);
step seven, selecting an optimal array combination to obtain each waveform of the n ^2 segmentation areas, and recording the waveform as Pi (r, theta), (i ^ 1,2, …, n ^ 2);
step eight, designing the micro-lens structure of the corresponding area of the corneal contact lens, enabling the light wave to form a corresponding waveform in the area after passing through the corneal shaping lens and the cornea, and outputting the distribution of the micro-lens structure as a final result.
2. The method of claim 1, wherein in the first step, the surface data is acquired by a corneal topographer, a Scheimpflug principle or an OCT principle three-dimensional imaging device.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011464484.7A CN112415774A (en) | 2020-12-14 | 2020-12-14 | Design method of corneal contact lens |
| PCT/CN2021/095682 WO2022127030A1 (en) | 2020-12-14 | 2021-05-25 | Method for designing contact lens |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011464484.7A CN112415774A (en) | 2020-12-14 | 2020-12-14 | Design method of corneal contact lens |
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| CN112415774A true CN112415774A (en) | 2021-02-26 |
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| WO (1) | WO2022127030A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022127030A1 (en) * | 2020-12-14 | 2022-06-23 | 上海美沃精密仪器股份有限公司 | Method for designing contact lens |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6086204A (en) * | 1999-09-20 | 2000-07-11 | Magnante; Peter C. | Methods and devices to design and fabricate surfaces on contact lenses and on corneal tissue that correct the eye's optical aberrations |
| JP2001188205A (en) * | 1999-09-22 | 2001-07-10 | Essilor Internatl (Cie Gen Opt) | Method for determining shape of contact lens for correcting non-focusing, namely optical aberration exceeding astigmatism and system for implementing the method |
| US20040183996A1 (en) * | 2000-12-22 | 2004-09-23 | Patricia Ann Piers | Methods of obtaining ophthalmic lenses providing the eye with reduced aberrations |
| US20050134799A1 (en) * | 2003-03-28 | 2005-06-23 | Thompson Keith P. | Application of neuro-ocular wavefront data in vision correction |
| CN101957502A (en) * | 2010-08-31 | 2011-01-26 | 吉林大学 | Design method of individualized cornea contact lens |
| US20110166651A1 (en) * | 2008-09-09 | 2011-07-07 | Werner Fiala | Lens Having Independent Non-Interfering Partial Zones |
| CN102129132A (en) * | 2011-03-29 | 2011-07-20 | 南开大学 | Design method for cornea contact lens based on wave front technology |
| US20150131054A1 (en) * | 2012-07-10 | 2015-05-14 | Wavelight Gmbh | Process and apparatus for determining optical aberrations of an eye |
| WO2018046440A1 (en) * | 2016-09-06 | 2018-03-15 | Eidgenoessische Technische Hochschule Zurich (Ethz) | Ray-tracing methods for realistic interactive ultrasound simulation |
| CN109031696A (en) * | 2018-08-20 | 2018-12-18 | 赵佩韬 | Eyesight control eyeglass and glasses based on periphery lenticule |
| CN109512380A (en) * | 2018-11-02 | 2019-03-26 | 爱尔眼科医院集团股份有限公司 | The method for making full retina dioptric topographic map based on wavefront sensing technique |
| US20190146242A1 (en) * | 2016-07-19 | 2019-05-16 | CarI Zeiss Vision International GmbH | Spectacle lens and method for producing a spectacle lens |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6701400A (en) * | 1999-08-11 | 2001-03-13 | Asclepion-Meditec Ag | Method and device for completely correcting visual defects of the human eye |
| CN101140357A (en) * | 2006-09-05 | 2008-03-12 | 南开大学 | Cornea contact lens design based on personalized human-eye model |
| US8862447B2 (en) * | 2010-04-30 | 2014-10-14 | Amo Groningen B.V. | Apparatus, system and method for predictive modeling to design, evaluate and optimize ophthalmic lenses |
| US8944594B2 (en) * | 2012-12-14 | 2015-02-03 | The Regents Of The University Of Colorado | Systems and methods for creating aberration-corrected gradient index lenses |
| CN112415774A (en) * | 2020-12-14 | 2021-02-26 | 上海美沃精密仪器股份有限公司 | Design method of corneal contact lens |
-
2020
- 2020-12-14 CN CN202011464484.7A patent/CN112415774A/en active Pending
-
2021
- 2021-05-25 WO PCT/CN2021/095682 patent/WO2022127030A1/en active Application Filing
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6086204A (en) * | 1999-09-20 | 2000-07-11 | Magnante; Peter C. | Methods and devices to design and fabricate surfaces on contact lenses and on corneal tissue that correct the eye's optical aberrations |
| JP2001188205A (en) * | 1999-09-22 | 2001-07-10 | Essilor Internatl (Cie Gen Opt) | Method for determining shape of contact lens for correcting non-focusing, namely optical aberration exceeding astigmatism and system for implementing the method |
| US20040183996A1 (en) * | 2000-12-22 | 2004-09-23 | Patricia Ann Piers | Methods of obtaining ophthalmic lenses providing the eye with reduced aberrations |
| US20050134799A1 (en) * | 2003-03-28 | 2005-06-23 | Thompson Keith P. | Application of neuro-ocular wavefront data in vision correction |
| US20110166651A1 (en) * | 2008-09-09 | 2011-07-07 | Werner Fiala | Lens Having Independent Non-Interfering Partial Zones |
| CN101957502A (en) * | 2010-08-31 | 2011-01-26 | 吉林大学 | Design method of individualized cornea contact lens |
| CN102129132A (en) * | 2011-03-29 | 2011-07-20 | 南开大学 | Design method for cornea contact lens based on wave front technology |
| US20150131054A1 (en) * | 2012-07-10 | 2015-05-14 | Wavelight Gmbh | Process and apparatus for determining optical aberrations of an eye |
| US20190146242A1 (en) * | 2016-07-19 | 2019-05-16 | CarI Zeiss Vision International GmbH | Spectacle lens and method for producing a spectacle lens |
| WO2018046440A1 (en) * | 2016-09-06 | 2018-03-15 | Eidgenoessische Technische Hochschule Zurich (Ethz) | Ray-tracing methods for realistic interactive ultrasound simulation |
| CN109031696A (en) * | 2018-08-20 | 2018-12-18 | 赵佩韬 | Eyesight control eyeglass and glasses based on periphery lenticule |
| CN109512380A (en) * | 2018-11-02 | 2019-03-26 | 爱尔眼科医院集团股份有限公司 | The method for making full retina dioptric topographic map based on wavefront sensing technique |
Non-Patent Citations (1)
| Title |
|---|
| 饶丰等: "角膜手术后眼模型的构建和人工晶状体设计", 《光子学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022127030A1 (en) * | 2020-12-14 | 2022-06-23 | 上海美沃精密仪器股份有限公司 | Method for designing contact lens |
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| WO2022127030A1 (en) | 2022-06-23 |
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