CN112384634A - 骨质疏松生物标志物及其用途 - Google Patents

骨质疏松生物标志物及其用途 Download PDF

Info

Publication number
CN112384634A
CN112384634A CN201880092711.2A CN201880092711A CN112384634A CN 112384634 A CN112384634 A CN 112384634A CN 201880092711 A CN201880092711 A CN 201880092711A CN 112384634 A CN112384634 A CN 112384634A
Authority
CN
China
Prior art keywords
analog
ruminococcus
bacteroides
osteoporosis
biomarker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201880092711.2A
Other languages
English (en)
Other versions
CN112384634B (zh
Inventor
王奇
郭锐进
鞠艳梅
贾慧珏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BGI Shenzhen Co Ltd
Original Assignee
BGI Shenzhen Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BGI Shenzhen Co Ltd filed Critical BGI Shenzhen Co Ltd
Publication of CN112384634A publication Critical patent/CN112384634A/zh
Application granted granted Critical
Publication of CN112384634B publication Critical patent/CN112384634B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)

Abstract

本发明涉及骨质疏松生物标志物及其用途。所述生物标志物包括多形拟杆菌(Bacteroides thetaiotaomicron),单形拟杆菌(Bacteroides uniformis),Bacteroides intestinalis,Bacteroides dorei,瘤胃球菌(Ruminococcus sp.),嗜粘蛋白‑艾克曼菌Akkermansia muciniphila,Parabacteroides merdae,扭链瘤胃球菌Ruminococcus torques,Dialister invisus及它们的类似物。

Description

PCT国内申请,说明书已公开。

Claims (34)

  1. PCT国内申请,权利要求书已公开。
CN201880092711.2A 2018-04-24 2018-04-24 骨质疏松生物标志物及其用途 Active CN112384634B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/084276 WO2019204985A1 (zh) 2018-04-24 2018-04-24 骨质疏松生物标志物及其用途

Publications (2)

Publication Number Publication Date
CN112384634A true CN112384634A (zh) 2021-02-19
CN112384634B CN112384634B (zh) 2024-04-16

Family

ID=68294361

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880092711.2A Active CN112384634B (zh) 2018-04-24 2018-04-24 骨质疏松生物标志物及其用途

Country Status (2)

Country Link
CN (1) CN112384634B (zh)
WO (1) WO2019204985A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020030709A1 (en) 2018-08-09 2020-02-13 Sony Corporation Methods, communications device and infrastructure equipment
CN112957376A (zh) * 2019-12-14 2021-06-15 山东大学 一种调节高原人群血糖的微生物组合物及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1515254A (zh) * 1996-02-28 2004-07-28 骨质疏松症的联合疗法
CN102154450A (zh) * 2010-12-23 2011-08-17 深圳华大基因科技有限公司 一种检测肠炎致病菌的方法
WO2015170979A1 (en) * 2014-05-06 2015-11-12 Is-Diagnostics Ltd. Microbial population analysis
CN107075446A (zh) * 2014-09-30 2017-08-18 深圳华大基因科技有限公司 用于肥胖症相关疾病的生物标记物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1515254A (zh) * 1996-02-28 2004-07-28 骨质疏松症的联合疗法
CN102154450A (zh) * 2010-12-23 2011-08-17 深圳华大基因科技有限公司 一种检测肠炎致病菌的方法
WO2015170979A1 (en) * 2014-05-06 2015-11-12 Is-Diagnostics Ltd. Microbial population analysis
CN107075446A (zh) * 2014-09-30 2017-08-18 深圳华大基因科技有限公司 用于肥胖症相关疾病的生物标记物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
董万涛;黄凯;宋敏;侯红燕;宋志靖;周灵通;刘小钰;蒋林博;: "肠道微生态失衡为骨质疏松症发病的易感因素", 中国骨质疏松杂志, no. 03, pages 119 - 123 *

Also Published As

Publication number Publication date
CN112384634B (zh) 2024-04-16
WO2019204985A1 (zh) 2019-10-31

Similar Documents

Publication Publication Date Title
CN111430027B (zh) 基于肠道微生物的双相情感障碍生物标志物及其筛选应用
CN112119167B (zh) 抑郁症生物标志物及其用途
CN105368944B (zh) 可检测疾病的生物标志物及其用途
Shi et al. Alterations in the intestinal microbiota of patients with severe and active Graves’ orbitopathy: a cross-sectional study
CN110904213B (zh) 一种基于肠道菌群的溃疡性结肠炎生物标志物及其应用
CN104603283A (zh) 确定异常状态相关生物标志物的方法及系统
CN110241205A (zh) 一种基于肠道菌群的精神分裂症生物标志物组合及其应用与筛选
CN111020020A (zh) 一种精神分裂症的生物标志物组合、其应用及metaphlan2筛选方法
CN104769132A (zh) 肝脏相关的炎性疾病的基因标记
CN111505288A (zh) 一种新的抑郁症生物标志物及其应用
CN110838365A (zh) 肠易激综合症相关菌群标志物及其试剂盒
CN112748191A (zh) 诊断急性疾病的小分子代谢物生物标志物及其筛选方法和应用
CN112384634B (zh) 骨质疏松生物标志物及其用途
CN110396538B (zh) 偏头痛生物标志物及其用途
CN113913490A (zh) 非酒精性脂肪肝标志微生物及其应用
CN114317671A (zh) 可作为1型糖尿病生物标志物的肠道细菌和粪便代谢物及其应用
CN111020021A (zh) 一种基于肠道菌群的小规模精神分裂症生物标志物组合、其应用及mOTU筛选方法
CN112011605B (zh) 微生物菌群在疾病诊断中的应用
CN109689890A (zh) 用于子宫腺肌症检测的生物标志物组合及其应用
CN110396537B (zh) 哮喘生物标志物及其用途
CN109266733B (zh) 自闭症肠道菌群毒力因子基因及其应用
CN112063709A (zh) 一种以微生物作为诊断标志物的重症肌无力的诊断试剂盒及应用
CN112877417A (zh) 多囊卵巢综合征肠道菌群生物标志物筛选及其应用
CN113166815B (zh) 肠道宏基因组在筛选pd-1抗体阻断剂疗效方面的用途
US20240290431A1 (en) Biomarker and diagnosis system for colorectal cancer detection

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant