CN112353800A - 透明质酸或其盐和/或海藻糖的组合物及其在稳定麦角硫因中的用途 - Google Patents
透明质酸或其盐和/或海藻糖的组合物及其在稳定麦角硫因中的用途 Download PDFInfo
- Publication number
- CN112353800A CN112353800A CN202011249538.8A CN202011249538A CN112353800A CN 112353800 A CN112353800 A CN 112353800A CN 202011249538 A CN202011249538 A CN 202011249538A CN 112353800 A CN112353800 A CN 112353800A
- Authority
- CN
- China
- Prior art keywords
- salt
- ergothioneine
- trehalose
- hyaluronic acid
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229940093497 ergothioneine Drugs 0.000 title claims abstract description 75
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 title claims abstract description 63
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 62
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Abstract
Description
样品浓度(%) | 0.05 | 0.1 | 0.2 | 0.3 |
ROS清除率(%) | 20.19 | 32.43 | 26.71 | 23.15 |
ROS抑制率(%) | 10.01 | 19.28 | 16.71 | 17.45 |
分组 | 处理方法 |
正常组 | 不照射,加无血清培养基 |
模型组 | UVB照射后,加无血清培养基 |
试验组 | UVB照射后,加不同浓度麦角硫因样品溶液 |
分组 | 处理方法 |
正常组 | 加无血清培养基,不照射 |
模型组 | 加无血清培养基后,UVB照射 |
试验组 | 加不同浓度的麦角硫因样品溶液后,UVB照射 |
样品浓度(%) | 0.05 | 0.1 | 0.2 | 0.3 |
防护作用的凋亡抑制率(%) | 6.05 | 8.28 | 4.41 | 5.29 |
修复作用的凋亡抑制率(%) | 21.31 | 34.22 | 27.63 | 19.81 |
Claims (10)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
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CN202210452898.0A CN114681451B (zh) | 2020-11-10 | 2020-11-10 | 透明质酸或其盐和/或海藻糖的组合物及其在稳定麦角硫因中的用途 |
CN202011249538.8A CN112353800B (zh) | 2020-11-10 | 2020-11-10 | 透明质酸或其盐和/或海藻糖的组合物及其在稳定麦角硫因中的用途 |
KR1020237019576A KR20230106669A (ko) | 2020-11-10 | 2021-11-09 | 에르고티오네인의 안정화에 있어서의 히알루론산 또는 그 염 및/또는 트레할로오스의 용도, 및 히알루론산 또는 그 염 및/또는 트레할로오스를 함유하는 에르고티오네인 조성물 |
EP21891087.5A EP4245304A4 (en) | 2020-11-10 | 2021-11-09 | USE OF HYALURONIC ACID OR A SALT THEREOF AND/OR TREHALOSE TO STABILIZE ERGOTHIONEIN AND ERGOTHIONEIN COMPOSITION WITH HYALURONIC ACID OR A SALT THEREOF AND/OR TREHALOSE |
JP2023529006A JP2023548948A (ja) | 2020-11-10 | 2021-11-09 | エルゴチオネインの安定化におけるヒアルロン酸又はその塩及び/又はトレハロースの使用、及びヒアルロン酸又はその塩及び/又はトレハロースを含有するエルゴチオネイン組成物 |
US18/036,257 US20230407238A1 (en) | 2020-11-10 | 2021-11-09 | Use of hyaluronic acid or salt thereof and/or trehalose in stabilizing ergothioneine, and ergothioneine composition containing hyaluronic acid or salt thereof and/or trehalose |
PCT/CN2021/129504 WO2022100567A1 (zh) | 2020-11-10 | 2021-11-09 | 透明质酸或其盐和/或海藻糖在稳定麦角硫因中的用途,及含有透明质酸或其盐和/或海藻糖的麦角硫因组合物 |
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CN202011249538.8A CN112353800B (zh) | 2020-11-10 | 2020-11-10 | 透明质酸或其盐和/或海藻糖的组合物及其在稳定麦角硫因中的用途 |
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CN112353800A true CN112353800A (zh) | 2021-02-12 |
CN112353800A9 CN112353800A9 (zh) | 2021-09-10 |
CN112353800B CN112353800B (zh) | 2022-06-24 |
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CN202210452898.0A Active CN114681451B (zh) | 2020-11-10 | 2020-11-10 | 透明质酸或其盐和/或海藻糖的组合物及其在稳定麦角硫因中的用途 |
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US (1) | US20230407238A1 (zh) |
EP (1) | EP4245304A4 (zh) |
JP (1) | JP2023548948A (zh) |
KR (1) | KR20230106669A (zh) |
CN (2) | CN112353800B (zh) |
WO (1) | WO2022100567A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022100567A1 (zh) * | 2020-11-10 | 2022-05-19 | 华熙生物科技股份有限公司 | 透明质酸或其盐和/或海藻糖在稳定麦角硫因中的用途,及含有透明质酸或其盐和/或海藻糖的麦角硫因组合物 |
WO2022100568A1 (zh) * | 2020-11-10 | 2022-05-19 | 华熙生物科技股份有限公司 | 松蕈及其用于生产麦角硫因的方法 |
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CN112353800A9 (zh) | 2021-09-10 |
JP2023548948A (ja) | 2023-11-21 |
EP4245304A4 (en) | 2024-04-24 |
CN114681451A (zh) | 2022-07-01 |
EP4245304A1 (en) | 2023-09-20 |
US20230407238A1 (en) | 2023-12-21 |
CN114681451B (zh) | 2023-11-03 |
CN112353800B (zh) | 2022-06-24 |
KR20230106669A (ko) | 2023-07-13 |
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