CN112294917A - Compound preparation for treating gout with syndrome of accumulated damp-heat and preparation method thereof - Google Patents
Compound preparation for treating gout with syndrome of accumulated damp-heat and preparation method thereof Download PDFInfo
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Abstract
The invention provides a compound preparation for treating gout with syndrome of accumulation of damp-heat and a preparation method thereof, wherein the compound preparation is prepared from the following traditional Chinese medicine raw materials in parts by weight: 20-45 parts of rhizoma smilacis glabrae, 20-30 parts of yam rhizome, 10-15 parts of medicinal cyathula root, 10-15 parts of large-leaved gentian, 6-10 parts of Indian iphigenia bulb, 10-15 parts of red paeony root and 6-9 parts of cornus officinalis. The preparation method can be used for preparing granule. In the medicine formula, aiming at the fact that the arrowhead in the formula has the effects of clearing away heat and toxic materials, relieving swelling and dissipating stagnation; rhizoma Smilacis Glabrae, rhizoma Dioscoreae Septemlobae, rhizoma; large-leaved gentian for expelling wind-damp, dredging the channels and collaterals, clearing deficiency heat, moistening the body without worry of helping heat; the red peony root has the functions of cooling blood and dissipating blood, and adopts the traditional Chinese medicine for promoting blood circulation and removing blood stasis to help prevent renal fibrosis; aiming at the deficiency, the medicinal cyathula root can tonify the liver and kidney, promote blood circulation to remove blood stasis, and guide the medicament downward to directly reach the focus; dogwood fruit pulp has the effects of tonifying liver and kidney, and strengthening body resistance to consolidate constitution. The whole formula is overall viewed, the pathogenic factors are eliminated without damaging the body resistance, the tonifying is realized without remaining the pathogenic factors, and the medicines have the effects of clearing heat and eliminating dampness, and detoxifying and eliminating turbidity together.
Description
Technical Field
The invention relates to the field of compound preparations, in particular to a compound preparation for treating gout with syndrome of accumulated damp-heat and a preparation method thereof.
Background
Gout is a clinical syndrome in which elevated blood uric acid levels, and deposition of mono-sodiurrurate (MSU) crystals, are caused by purine metabolic disorders, resulting in tissue damage. The incidence rate of gout (and hyperuricemia) is rapidly increased, the trend of the gout (and hyperuricemia) is not well controlled in the last 30 years, the gout becomes the fourth highest after the third highest, and the health of people is seriously harmed. Epidemiological data from 2000 to 2014 show that the prevalence rate of gout in China is 1.1%, and the research results of 2004 on coastal areas and economically developed areas in Shandong China show that the prevalence rate of primary gout is close to the level of developed countries in Europe and America (the prevalence rate in the United states is 0.2-1.7%). Shenzhen and the Guangdong hong and Australia gulf region are regions with high gout incidence in China due to unique climatic factors, geographical environment, dietary structure, crowd physical conditions, working and living rhythm and the like. Take Shenzhen as an example, the gout incidence rate is 2.8%, which reaches 2-3 times of the national level, and the incidence is continuously younger. In recent years, researches show that gout not only affects joints and kidneys, but also can induce and aggravate the occurrence and development of modern epidemic diseases such as diabetes, coronary heart disease, hypertension and cerebrovascular diseases, seriously affect the life quality of patients and bring huge mental and economic burden to families and society. Therefore, effective measures are urgently needed to reduce gout occurrence, reduce disease burden and sanitary economic burden and improve the living health level of people.
Shenzhen and the Dawan region have thick traditional Chinese medicine culture and tradition, and have unique traditional Chinese medicine theoretical system and practical method in the aspect of gout prevention and treatment. Also has unique theoretical system and practical method in the aspect of preventing and curing gout. The traditional Chinese medicine differentiation and classification of gout comprises a damp-heat accumulation syndrome, a phlegm-stasis arthralgia syndrome, a spleen deficiency and damp-heat syndrome and a cold-damp arthralgia syndrome, and the type is different, and the treatment method and the prescription are different, so that the theory of traditional Chinese medicine differentiation and treatment is embodied. Ancient physicians considered that gout attack is closely related to dampness, heat and stasis, and that dampness and heat are the core of clinical syndrome differentiation and treatment of gout. In the early clinical research, 6,892 patients with acute gouty arthritis in 2008-2017 are analyzed for pathogenesis characteristics, and the syndrome of accumulation of damp-heat is found to be the most main syndrome type.
TCM advocates' treatment by differentiation of syndromes and treatment of disease, seeking the root cause of disease in the intricate and complex clinical manifestations, and eliminating disease from its root by selecting the correct treatment method according to the underlying cause and pathogenesis of disease. The formula is based on the theory of damp-heat in south of five Ridges, Shenzhen is located in subtropical zone, has high temperature and strong rain-dampness in the whole year, and combines the characteristics that people in coastal regions like eating seafood with soft and yin, often greet cold drink, damage spleen and stomach and internally generate damp turbidity. When damp turbidity is accumulated for a long time, endogenous damp heat is combined with external damp-heat climate, the endogenous damp heat is easy to be accumulated, stasis is generated when the damp heat is accumulated for a long time, blood stasis blocks collaterals, and joints are blocked, so that symptoms such as joint red swelling and hot pain appear, and heat-decocted yin consumption liquid of the damp stasis becomes sand stone; damp-heat with blood stasis, lingering and difficult to heal, and deficiency after long-term disease, leading to deficiency of qi and yin of the kidney, obstruction of the kidney collaterals and complications of kidney stones, chronic renal insufficiency, etc. According to the principle of treating the symptoms of gout by the acute rule and treating the root cause by the slow rule in the traditional Chinese medicine, aiming at the pain of a patient caused by acute gout attack, the Indian iphigenia bulb turbid-removing prescription (gout tai) is prepared by adopting the principle of clearing heat and promoting diuresis, detoxifying and dissolving turbid and removing blood stasis and relieving pain. Damp-heat is the core of clinical syndrome differentiation and treatment of gout, and runs through the general course of the disease. Therefore, the Indian iphigenia bulb turbid pathogen removing formula (gout tai) for clearing heat and promoting diuresis for treating gout is worthy of further clinical popularization.
Disclosure of Invention
The invention aims to promote a Cilian turbid-eliminating prescription (gout tai) for clearing heat and promoting diuresis to treat gout, and provides a compound preparation for treating gout with syndrome of damp-heat accumulation and a preparation method thereof.
The technical scheme for realizing the technical purpose of the invention is as follows: a compound preparation for treating gout with syndrome of accumulated damp-heat is prepared from the following traditional Chinese medicine raw materials in parts by weight:
20-45 parts of glabrous greenbrier rhizome,
20 to 30 portions of yam rhizome,
10-15 parts of medicinal cyathula root,
10-15 parts of gentiana macrophylla pall,
6-10 parts of edible tulip bulb,
10-15 parts of red paeony root,
6-9 parts of cornus officinalis.
Further, in the compound preparation for treating gout with syndrome of accumulated damp-heat: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 45 parts of glabrous greenbrier rhizome, 30 parts of yam rhizome, 10 parts of medicinal cyathula root, 10 parts of large-leaved gentian, 10 parts of Indian iphigenia bulb, 10 parts of red paeony root and 6 parts of cornus fruit.
The invention also provides a preparation method of the compound preparation for treating gout with syndrome of accumulation of damp-heat, which comprises the following steps:
step 1, taking the raw materials of the traditional Chinese medicines according to the proportion;
step 2, decocting: decocting for 2 times, adding 8-12 times of water each time, decocting for 1.2-1.8 hr for the first time and 0.8-1.2 hr for the second time, mixing, and filtering;
and step 3, concentrating: extracting the filtrate, and concentrating under reduced pressure at 60-80 ℃ under 0.045-0.065Mpa to obtain fluid extract with relative density of 1.20-1.25.
Further, in the above method: further comprising the steps of:
step 4, granulating: adding dextrin as adjuvant at the weight ratio of the fluid extract to dextrin of 1: 1.5-2, mixing, transferring to granulator, and wet granulating;
and step 5, drying: transferring the wet-granulated particles into a hot air circulation oven at 60-80 ℃ for drying;
step 6, straightening granules: the particles are transferred to a granulating machine for granulating, and particles of 10-80 meshes are collected;
and 7, taking the qualified particles and the polyester/aluminized polyester/polyethylene composite film for medicine packaging, and sealing the qualified particles into each bag in a heat sealing manner.
Further, in the above method: adding 10 times of water during decocting, decocting for 1.5 hr for the first time, decocting for 1 hr for the second time, and filtering with 200 mesh sieve.
Further, in the above method: concentrating under 0.055Mpa at 60-80 deg.C.
Further, in the above method: when granulating, the weight ratio of the clear paste to the dextrin is 1: 1.72.
In the medicine formula, aiming at the fact that the arrowhead in the formula has the effects of clearing away heat and toxic materials, relieving swelling and dissipating stagnation; rhizoma Smilacis Glabrae, rhizoma Dioscoreae Septemlobae, rhizoma; large-leaved gentian for expelling wind-damp, dredging the channels and collaterals, clearing deficiency heat, moistening the body without worry of helping heat; the red peony root has the functions of cooling blood and dissipating blood, and adopts the traditional Chinese medicine for promoting blood circulation and removing blood stasis to help prevent renal fibrosis; aiming at the deficiency, the medicinal cyathula root can tonify the liver and kidney, promote blood circulation to remove blood stasis, and guide the medicament downward to directly reach the focus; dogwood fruit pulp has the effects of tonifying liver and kidney, and strengthening body resistance to consolidate constitution. The whole formula is overall viewed, the traditional Chinese medicine composition has the effects of tonifying without retaining pathogenic factors, eliminating pathogenic factors without damaging vital qi, and clearing heat, eliminating dampness, detoxifying and eliminating turbidity.
The modern Chinese medicinal pharmacological research shows that the edible tulip contains colchicine, can quickly diminish inflammation and relieve pain, and has special effect on acute gout; rhizoma Smilacis Glabrae and rhizoma Dioscoreae Septemlobae can reduce blood uric acid; radix Paeoniae Rubra helps to prevent renal fibrosis; the gentiana macrophylla can dissolve uric acid and relieve pain caused by uric acid; corni fructus can reduce urine protein and protect renal function.
The invention will be explained in more detail below with reference to the drawings and examples.
Drawings
FIG. 1 is a flow chart of a preparation scheme of the invention.
Detailed Description
The embodiment provides a compound preparation for treating gout with syndrome of accumulated damp-heat, which is prepared from the following traditional Chinese medicine raw materials in parts by weight:
20-45 parts of rhizoma smilacis glabrae, 20-30 parts of yam rhizome, 10-15 parts of medicinal cyathula root, 10-15 parts of large-leaved gentian, 6-10 parts of Indian iphigenia bulb, 10-15 parts of red paeony root and 6-9 parts of cornus officinalis.
Gout with accumulation of damp-heat is manifested by swelling and pain of local joints, acute onset of disease, and symptoms of one or more joints, such as fever, aversion to wind, thirst, restlessness, headache, sweating, scanty and yellow urine, red tongue with yellow coating, yellow and greasy tongue coating, and wiry and smooth pulse. Aiming at the treatment of gout with damp-heat accumulation, the traditional treatment method mainly adopts the treatment means of clearing heat and promoting diuresis, and dredging collaterals and relieving pain, but the treatment means only starts from the 'standard excess' of gout and neglects the 'intrinsic deficiency' effect of gout. The traditional Chinese medicine holds that the liver stores blood and the liver stores ; kidneys store essence, they govern bones, produce essence and blood mutually, and make liver and kidney homologous. Liver pertains to wood, kidney pertains to water, and both of them nourish one another and are damaged by one injury. Gout is caused by liver and kidney deficiency, essence and blood deficiency, malnutrition of muscles and bones, qi deficiency of liver and kidney, and susceptibility to wind-cold-dampness. The symptoms of deficiency of liver and kidney, deficiency of qi and blood, and mixed deficiency and excess, manifested as damp-heat, turbid phlegm and blood stasis. Therefore, the characteristics of Shenzhen region climate, life style, eating habits, work rhythm and the like are closely combined, so that the long-term accumulation of damp turbidity and endogenous damp-heat are emphasized, and the combination of the endogenous damp-heat and the exogenous damp-heat climate easily causes the accumulation of damp-heat in the interior, and the long-term accumulation of damp-heat generates stasis, so that blood stasis and collateral obstruction are caused, the dampness-heat in joints are blocked, and lingering and difficult to heal. Aiming at the characteristics, on the basis of clearing heat and promoting diuresis, the effects of promoting blood circulation, removing blood stasis and relieving pain are enhanced, and the dogwood and the medicinal cyathula root are added in the formula to tonify liver and kidney, strengthen body resistance and consolidate the constitution, so that pathogenic factors are eliminated without damaging body resistance.
The traditional Chinese medicine is prepared by the following method: weighing the traditional Chinese medicine raw materials according to the formula, adding the traditional Chinese medicine raw materials into a container, adding water to overflow the medicine surface, soaking for 20-30 minutes, adding water to submerge the medicine surface for 3-5 centimeters, decocting with strong fire until the medicine surface is boiled, then decocting with slow fire for 30-40 minutes, and taking filtrate; and then adding water to submerge the medicine surface by 3-5 cm, decocting with strong fire until the medicine surface is boiled, then decocting with slow fire for 15-20 minutes, removing residues, taking the filtrate, and combining the two filtrates. The composition is administered twice a day at a dose of 200ml each time.
The traditional decoction cannot well meet the requirements of modern urban people due to inconvenient carrying and large dosage, and the invention further develops the formula into granules which are convenient for patients to take. The preparation process comprises the following steps:
decocting: adding 10 times of water into the seven medicines, decocting for 2 times, decocting for 1.5 hours for the first time and decocting for 1.0 hour for the second time, filtering, combining filtrates, concentrating under reduced pressure to obtain clear paste with the relative density of about 1.20-1.25 (70 ℃), adding an appropriate amount of dextrin, mixing uniformly, granulating by a wet method, drying, and preparing 1000 g.
The preparation method comprises the following steps:
1) decocting: decocting seven medicines such as rhizoma Smilacis Glabrae for 2 times, adding 10 times of water each time, decocting for 1.5 hr and 1.0 hr for the first time, mixing filtrates, and filtering (200 mesh screen) for use.
2) Concentration: concentrating the extract under reduced pressure (-0.055 Mpa, 60-80 deg.C) to relative density of 1.20-1.25 (70 deg.C), cooling, inspecting fluid extract appearance, coke breeze and insoluble substance and relative density (70 deg.C), and weighing after qualified.
3) And (3) granulating: adding adjuvants at a ratio of fluid extract to dextrin (1: 1.72), mixing, transferring to a granulator, and wet granulating.
4) And (3) drying: drying in a hot air circulation oven at the temperature of 60-80 ℃ for later use.
5) Finishing: and (4) transferring the particles to a granulating machine for granulating, and collecting the particles with 10-80 meshes for later use.
6) Subpackaging: and (3) taking the qualified particles and the polyester/aluminized polyester/polyethylene composite film for medicine packaging, and sealing the qualified particles into each bag in a heat sealing manner.
The flow chart of the preparation process is shown in figure 1.
Pharmacological analysis:
and (3) edible tulip: sweet, slightly pungent and cool. It enters liver and spleen meridians. Clear heat and remove toxicity, resolve phlegm and dissipate nodulation.
Glabrous greenbrier rhizome: sweet and bland in flavor and neutral in nature; it enters liver, stomach and spleen meridians. Clearing heat and removing dampness; discharging turbidity and detoxifying; to smooth the joints.
Rhizoma Dioscoreae Septemlobae: bitter and sweet, neutral. Meridian tropism: enter liver, kidney and stomach meridians. Induce diuresis to remove turbid pathogen, dispel wind to remove arthralgia.
Large-leaved gentian: pungent, bitter and mild; it enters stomach, liver and gallbladder meridians. Dispelling wind-damp, clearing cold-damp, stopping arthralgia, moistening without worry of heat-assisted;
radix cyathulae: sweet, slightly bitter and neutral in nature; it enters liver and kidney meridians. Promoting blood circulation, dispelling blood stasis, dispelling pathogenic wind, and removing dampness.
Red peony root: bitter and slightly cold; entering liver meridian, clearing heat and cooling blood; promoting blood circulation and removing blood stasis.
Cornus officinalis: sour and astringent taste, slightly warm nature, entering liver and kidney meridians, tonifying liver and kidney, inducing astringency and relieving depletion.
In the medicine formula, aiming at the marked excess, the Indian iphigenia bulb has the effects of clearing heat and removing toxicity, relieving swelling and dissipating stagnation; rhizoma Smilacis Glabrae, rhizoma Dioscoreae Septemlobae, rhizoma; large-leaved gentian for expelling wind-damp, dredging the channels and collaterals, clearing deficiency heat, moistening the body without worry of helping heat; the red peony root has the functions of cooling blood and dissipating blood, and adopts the traditional Chinese medicine for promoting blood circulation and removing blood stasis to help prevent renal fibrosis; aiming at the deficiency, the medicinal cyathula root can tonify the liver and kidney, promote blood circulation to remove blood stasis, and guide the medicament downward to directly reach the focus; dogwood fruit pulp has the effects of tonifying liver and kidney, and strengthening body resistance to consolidate constitution. The whole formula is overall viewed, the traditional Chinese medicine composition has the effects of tonifying without retaining pathogenic factors, eliminating pathogenic factors without damaging vital qi, and clearing heat, eliminating dampness, detoxifying and eliminating turbidity.
The modern Chinese medicinal pharmacological research shows that the edible tulip contains colchicine, can quickly diminish inflammation and relieve pain, and has special effect on acute gout; rhizoma Smilacis Glabrae and rhizoma Dioscoreae Septemlobae can reduce blood uric acid; radix Paeoniae Rubra helps to prevent renal fibrosis; the gentiana macrophylla can dissolve uric acid and relieve pain caused by uric acid; corni fructus can reduce urine protein and protect renal function.
The preparation has the advantages that the used traditional Chinese medicine conforms to the stipulation of the national drug code of the people's republic of China, and the medicine is safe and reliable. The medicines are used for treating the damp-heat accumulation type pain and the wind syndrome excess and the deficiency, and have the effects of clearing heat and expelling dampness, removing blood stasis, tonifying liver and kidney and treating both principal and secondary aspects of diseases.
And (3) judging the curative effect:
1. inclusion criteria
120 cases of gout patients with confirmed syndrome of damp-heat accumulation were selected, wherein 109 cases of men and 11 cases of women were selected, the minimum was 20 years old, the maximum was 71 years old, and the average age was (42.82 + -11.24) years old.
2. The treatment method comprises the following steps: the traditional Chinese medicine preparation is taken orally 2 times a day, 1 time in the morning and at night, 200ml each time, and 14 days are a treatment course.
3. Clinical efficacy evaluation criteria
1) The symptom grading standard refers to the Chinese medicine industry standard of the people's republic of China, namely the diagnosis and treatment effect standard of Chinese medicine symptoms (ZY/T001.1-94) and the gout related treatment effect evaluation standard of the 1994 Chinese medicine new medicine clinical research guideline. Symptom integral grading quantization index:
(1) 11-point pain level numerical rating scale (NRS-11): score 0 indicates no pain, score 10 indicates the most severe pain that can be imagined; 1-3 points out mild pain, but normal activities can still be performed; 4-6 points indicate moderate pain, which affects work, but can lead to self-care; 7-9 points indicate severe pain and no self-care in life; a score of 10 indicates severe pain, which is intolerable.
(2) Swelling of joints:
0 minute: no swelling or disappearance of swelling of the joints; 1 minute: swelling of joints, reddened skin; and 2, dividing: significant swelling of joints, redness of skin;
and 3, dividing: high swelling of joints, dark red skin;
(3) the activity is limited: 0 minute: the joint movement is normal; 1 minute: joint movement is limited; and 2, dividing: joint movement is significantly limited; and 3, dividing: joint motion is severely limited.
According to the total integral reduction ratio of symptoms and signs of a subject, the clinical recovery, the effectiveness and the ineffectiveness are divided into four grades.
(1) The clinical recovery is that the clinical symptoms and physical signs of the traditional Chinese medicine disappear or basically disappear, and the syndrome integral is more than or equal to 95 percent
(2) Has obvious effects that the clinical symptoms and physical signs of the traditional Chinese medicine are obviously improved, and the syndrome integral is more than or equal to 70 percent and is more than 95 percent
(3) Has the advantages of improving clinical symptoms and physical signs of the traditional Chinese medicine, and having the syndrome integral of more than or equal to 30 percent in 70 percent
(4) The traditional Chinese medicine clinical symptoms and physical signs are improved, and the syndrome score is less than 30 percent
Note: calculation formula (nimodipine method): [ (before treatment integration-after treatment integration) ]/before treatment integration ] × 100%
As a result: 55 cases are cured clinically, 42 cases are improved, 3 cases are invalid, and the total effective rate is 97%.
Example 1: the traditional Chinese medicine preparation for treating gout with syndrome of accumulated damp-heat is prepared from the following traditional Chinese medicine raw materials in parts by weight: 45 parts of glabrous greenbrier rhizome, 30 parts of yam rhizome, 10 parts of medicinal cyathula root, 10 parts of large-leaved gentian, 10 parts of Indian iphigenia bulb, 10 parts of red paeony root and 6 parts of cornus fruit.
Example 2: the traditional Chinese medicine preparation for treating gout with syndrome of accumulated damp-heat is prepared from the following traditional Chinese medicine raw materials in parts by weight: 20 parts of glabrous greenbrier rhizome, 15 parts of yam rhizome, 10 parts of medicinal cyathula root, 10 parts of large-leaved gentian, 9 parts of Indian iphigenia bulb, 10 parts of red paeony root and 6 parts of cornus fruit.
Example 3: the traditional Chinese medicine preparation for treating gout with syndrome of accumulated damp-heat is prepared from the following traditional Chinese medicine raw materials in parts by weight: 30 parts of glabrous greenbrier rhizome, 20 parts of yam rhizome, 15 parts of medicinal cyathula root, 15 parts of large-leaved gentian, 9 parts of Indian iphigenia bulb, 15 parts of red paeony root and 6 parts of cornus fruit.
Example 4: examples 1 to 3 were prepared as follows: weighing the traditional Chinese medicine raw materials according to the formula, adding the traditional Chinese medicine raw materials into a container, adding water to the container to soak the medicine surface for 30 minutes, adding water to the container to submerge the medicine surface for 5 centimeters, decocting the medicine with strong fire until the medicine is boiled, decocting the medicine with slow fire for 30 minutes, and taking filtrate; then adding water to submerge the medicine surface by 5 cm, decocting with strong fire until boiling, decocting with slow fire for 20 minutes, removing residues, taking the filtrate, and mixing the two filtrates. The composition is administered twice a day at 200ml each time.
Typical cases are:
1, morning and evening primrose, male, 59 years old, sudden red swelling and pain of left knee joint, limited movement, red tongue with yellow and greasy coating, and slippery pulse before 2 days. The body is healthy, the uric acid is raised, and the systemic diagnosis and treatment are not performed. Takes effect in the day of taking, relieves the pain within 6 to 7 hours and has satisfactory curative effect.
2. When the male is in 36 years old, the perennial uric acid is increased to 590umol/L, the seafood is eaten recently, the 1 st metatarsophalangeal joint of the left foot is red, swollen and hot, and has severe pain, can be accommodated, has poor sleep, and is convenient to adjust. Pain was halved on the day of administration and was substantially relieved after 3 days.
3. Yang Yi, male, age 44, history of gout, frequent attack, swelling and pain of right knee joint of 1 month and half, taking Futalin by oneself, external analgesic ointment has no relief, sleeping peaceful, red tongue with thin and yellow coating, and slippery pulse. The swelling and pain is basically relieved after the medicine is taken for 2 weeks, and the movement is free.
Claims (7)
1. A compound preparation for treating gout with syndrome of accumulated damp-heat is characterized in that: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight:
20-45 parts of glabrous greenbrier rhizome,
20 to 30 portions of yam rhizome,
10-15 parts of medicinal cyathula root,
10-15 parts of gentiana macrophylla pall,
6-10 parts of edible tulip bulb,
10-15 parts of red paeony root,
6-9 parts of cornus officinalis.
2. The compound preparation for treating gout with syndrome of accumulation of damp-heat according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 45 parts of glabrous greenbrier rhizome, 30 parts of yam rhizome, 10 parts of medicinal cyathula root, 10 parts of large-leaved gentian, 10 parts of Indian iphigenia bulb, 10 parts of red paeony root and 6 parts of cornus fruit.
3. A method for preparing a compound preparation for treating gout with syndrome of accumulation of damp-heat according to claims 1 and 2, which comprises the following steps: the method comprises the following steps:
step 1, taking the raw materials of the traditional Chinese medicines according to the proportion;
step 2, decocting: decocting for 2 times, adding 8-12 times of water each time, decocting for 1.2-1.8 hr for the first time and 0.8-1.2 hr for the second time, mixing, and filtering;
and step 3, concentrating: extracting the filtrate, and concentrating under reduced pressure at 60-80 ℃ under 0.045-0.065Mpa to obtain fluid extract with relative density of 1.20-1.25.
4. The method of claim 3, wherein: further comprising the steps of:
step 4, granulating: adding dextrin as adjuvant at the weight ratio of the fluid extract to dextrin of 1: 1.5-2, mixing, transferring to granulator, and wet granulating;
and step 5, drying: transferring the wet-granulated particles into a hot air circulation oven at 60-80 ℃ for drying;
step 6, straightening granules: the particles are transferred to a granulating machine for granulating, and particles of 10-80 meshes are collected;
and 7, taking the qualified particles and the polyester/aluminized polyester/polyethylene composite film for medicine packaging, and sealing the qualified particles into each bag in a heat sealing manner.
5. The method of claim 4, wherein: adding 10 times of water during decocting, decocting for 1.5 hr for the first time, decocting for 1 hr for the second time, and filtering with 200 mesh sieve.
6. The method of claim 4, wherein: concentrating under 0.055Mpa at 60-80 deg.C.
7. The method of claim 4, wherein: when granulating, the weight ratio of the clear paste to the dextrin is 1: 1.72.
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| CN101843811A (en) * | 2010-02-08 | 2010-09-29 | 崔晓廷 | Oral preparation special for treating gout |
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