CN112218880A - 逃避中和的肝趋向性重组aav6载体 - Google Patents

逃避中和的肝趋向性重组aav6载体 Download PDF

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Publication number
CN112218880A
CN112218880A CN201980035877.5A CN201980035877A CN112218880A CN 112218880 A CN112218880 A CN 112218880A CN 201980035877 A CN201980035877 A CN 201980035877A CN 112218880 A CN112218880 A CN 112218880A
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vector
modified
raav6
aav6
neutralization
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CN201980035877.5A
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Chinese (zh)
Inventor
R·裘德·萨穆尔斯基
梅维斯·阿格班德基-麦肯纳
安东内特·班尼特
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University of Florida Research Foundation Inc
AskBio Inc
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University of Florida Research Foundation Inc
Asklepios Biopharmaceutical Inc
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Application filed by University of Florida Research Foundation Inc, Asklepios Biopharmaceutical Inc filed Critical University of Florida Research Foundation Inc
Publication of CN112218880A publication Critical patent/CN112218880A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980035877.5A 2018-03-29 2019-03-28 逃避中和的肝趋向性重组aav6载体 Pending CN112218880A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862649691P 2018-03-29 2018-03-29
US62/649,691 2018-03-29
PCT/US2019/024567 WO2019191418A1 (en) 2018-03-29 2019-03-28 Liver tropic recombinant aav6 vectors that evade neutralization

Publications (1)

Publication Number Publication Date
CN112218880A true CN112218880A (zh) 2021-01-12

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CN201980035877.5A Pending CN112218880A (zh) 2018-03-29 2019-03-28 逃避中和的肝趋向性重组aav6载体

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US (1) US20210032660A1 (https=)
EP (1) EP3781187A4 (https=)
JP (1) JP2021519612A (https=)
CN (1) CN112218880A (https=)
CA (1) CA3095127A1 (https=)
WO (1) WO2019191418A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024066780A1 (zh) * 2022-09-30 2024-04-04 上海玮美基因科技有限责任公司 一种融合型新型腺相关病毒及其应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210017542A1 (en) * 2018-03-29 2021-01-21 University Of Florida Research Foundation, Incorporated Aav6 variants

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015121501A1 (en) * 2014-02-17 2015-08-20 King's College London Adeno-associated virus vector
CN105408486A (zh) * 2013-05-21 2016-03-16 佛罗里达大学研究基金会有限公司 衣壳修饰的raav3载体组合物以及在人肝癌基因治疗中的用途
WO2017058892A2 (en) * 2015-09-28 2017-04-06 The University Of North Carolina At Chapel Hill Methods and compositions for antibody-evading virus vectors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006110689A2 (en) * 2005-04-07 2006-10-19 The Trustees Of The University Of Pennsylvania Method of increasing the function of an aav vector
US9533189B2 (en) * 2012-05-30 2017-01-03 Jaime Cameron Push-up exercise apparatus
JP2017048681A (ja) * 2015-08-31 2017-03-09 株式会社マーレ フィルターシステムズ ポンプ
EP4659816A3 (en) * 2015-12-14 2025-12-31 The University of North Carolina at Chapel Hill MODIFIED CAPSID PROTEINS FOR IMPROVED PARVOVIRUS VECTOR DELIVERY

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105408486A (zh) * 2013-05-21 2016-03-16 佛罗里达大学研究基金会有限公司 衣壳修饰的raav3载体组合物以及在人肝癌基因治疗中的用途
WO2015121501A1 (en) * 2014-02-17 2015-08-20 King's College London Adeno-associated virus vector
WO2017058892A2 (en) * 2015-09-28 2017-04-06 The University Of North Carolina At Chapel Hill Methods and compositions for antibody-evading virus vectors

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANTONETTE D.BENNETT等: "AAV6 K531 serves a dual function inselective receptor and antibody ADK6 recognition", JOURNAL OF VIROLOGY, vol. 518, pages 369 - 376 *
F SONNTAG等: "The assembly-activating protein promotes capsid assembly of different adeno-associated virus serotypes", JOURNAL OF VIROLOGY, vol. 23, no. 85, pages 12686 - 97 *
HUANG LY等: "Characterization of the Adeno - Associated Virus 1 and 6 Sialic Acid Binding Site", JOURNAL OF VIROLOGY, vol. 11, no. 90, pages 5219 - 5230 *
ZHIJIAN WU等: "Single Amino Acid Changes Can Influence Titer, Heparin Binding, and Tissue Tropism in Different Adeno-Associated Virus Serotypes", JOURNAL OF VIROLOGY, vol. 22, no. 80, pages 11393 - 11397 *
卢超;万江波;唐明清;肖卫东;许瑞安;: "重组腺相关病毒载体的免疫性研究及其解决策略", 中国临床药理学与治疗学, no. 05, pages 103 - 109 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024066780A1 (zh) * 2022-09-30 2024-04-04 上海玮美基因科技有限责任公司 一种融合型新型腺相关病毒及其应用

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CA3095127A1 (en) 2019-10-03
US20210032660A1 (en) 2021-02-04
EP3781187A1 (en) 2021-02-24
JP2021519612A (ja) 2021-08-12
WO2019191418A1 (en) 2019-10-03
EP3781187A4 (en) 2021-12-22

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