CN112142462A - Method for manufacturing anti-inflammatory tooth restoration material with layer-by-layer self-assembly coating - Google Patents

Method for manufacturing anti-inflammatory tooth restoration material with layer-by-layer self-assembly coating Download PDF

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CN112142462A
CN112142462A CN202010908518.0A CN202010908518A CN112142462A CN 112142462 A CN112142462 A CN 112142462A CN 202010908518 A CN202010908518 A CN 202010908518A CN 112142462 A CN112142462 A CN 112142462A
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layer
coating
inflammatory
self
deionized water
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CN112142462B (en
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李国晶
赵化启
杨婷婷
杨涵崧
刘文斌
焦玉凤
王晶彦
何丽丽
姚潍
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Jiamusi University
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Jiamusi University
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Abstract

A method for manufacturing an anti-inflammatory tooth restoration material with a layer-by-layer self-assembly coating relates to a method for manufacturing a tooth restoration material. The invention aims to solve the problems that the existing zirconia ceramics have large brittleness and small fracture toughness, are easy to fracture and break porcelain and do not have anti-inflammation when being used as tooth restoration materials. The method comprises the following steps: firstly, preparing a solution A; secondly, preparing slurry; thirdly, preparing a ceramic block; fourthly, sintering; fifthly, self-assembling layer by layer to obtain the anti-inflammatory tooth restoration material with the layer by layer self-assembled coating. Compared with zirconia ceramics, the fracture toughness of the anti-inflammatory tooth restoration material with the layer-by-layer self-assembly coating prepared by the invention is improved by 1-1.5 times. The invention can obtain the anti-inflammatory tooth restoration material with the layer-by-layer self-assembly coating.

Description

Method for manufacturing anti-inflammatory tooth restoration material with layer-by-layer self-assembly coating
Technical Field
The present invention relates to a method for producing a dental restorative material.
Background
Teeth are a structure found in many vertebrates, the organs through which humans and tall animals chew food. Teeth are the hardest organs of the human body. Generally, teeth are white in color and hard in texture. The various shapes of teeth are suitable for a variety of uses, including tearing, grinding food. Restorative materials are one of the key areas of research in the dental field, since restorative materials are needed once a tooth is damaged.
At present, the dental prosthetic material is gradually developed from resin in the initial stage to metal, and finally developed to a zirconia denture material, the zirconia ceramic material has good comprehensive properties such as high melting point, high hardness, high wear resistance, oxidation resistance and the like, the raw material sources for production are sufficient, the manufacturing cost is low, and the material is suitable for large-scale industrial production, so the zirconia is gradually the dental prosthetic material favored by people, and in addition, the zirconia ceramic has good biocompatibility and has glaze texture and transparency close to natural teeth of human bodies. However, the low fracture toughness and high brittleness of zirconia ceramics limit their application because of their natural brittleness, which prevents further widespread use of such products.
Therefore, there is a strong need for a dental restorative material having high bending strength, high fracture toughness, anti-inflammation, and biocompatibility, and there is no report on such a restorative material.
Disclosure of Invention
The invention aims to solve the problems that the existing zirconia ceramics have large brittleness and small fracture toughness, are easy to fracture and break porcelain and do not have anti-inflammation when being used as tooth repairing materials, and provides a method for manufacturing an anti-inflammation tooth repairing material with a layer-by-layer self-assembly coating.
A method for manufacturing an anti-inflammatory tooth restoration material with a layer-by-layer self-assembly coating is completed according to the following steps:
firstly, uniformly mixing deionized water, sodium oleate, sodium carboxymethylcellulose and polyvinyl alcohol, and stirring to obtain a solution A;
the mass ratio of the deionized water to the sodium carboxymethyl cellulose in the first step is 100 (0.3-1);
the mass ratio of the deionized water to the polyvinyl alcohol in the first step is 100 (0.5-2);
the mass ratio of the deionized water to the sodium oleate in the first step is 100 (1.5-2);
secondly, adding nano zirconia powder, nano alumina powder and nano cerium dioxide powder into the solution A, and stirring to obtain slurry;
the mass ratio of the nano zirconia powder, the nano alumina powder and the nano ceria powder in the second step is 100 (4-8) to (8-15);
the mass ratio of the solution A to the nano zirconia powder in the step two is 100 (10-20);
thirdly, carrying out spray granulation on the slurry in a spray granulator, and pressing the obtained particles to obtain a ceramic block;
the thickness of the porcelain block in the third step is 15 mm-30 mm;
the pressing pressure in the third step is 80MPa to 150 MPa;
fourthly, placing the porcelain block into a muffle furnace, heating to 250-300 ℃ at a heating rate of 2-4 ℃/min, then preserving heat at 250-300 ℃ for 2-4 h, heating from 250-300 ℃ to 750-800 ℃ at a heating rate of 2-4 ℃/min, then preserving heat at 750-800 ℃ for 2-3 h, heating from 750-800 ℃ to 1500-1560 ℃ at a heating rate of 2-4 ℃/min, and then preserving heat at 1500-1560 ℃ for 1-2 h; obtaining a composite ceramic block toughened by alumina and cerium dioxide;
fifthly, self-assembling layer by layer:
firstly, immersing the composite ceramic block toughened by the alumina and the cerium dioxide into a polyvinyl alcohol solution for 5-10 min, taking out and drying; then placing the mixture into a tannic acid solution for soaking for 5min to 10min, taking out and drying;
the volume ratio of the mass of the polyvinyl alcohol in the polyvinyl alcohol solution in the step V to the deionized water is (1 g-2 g) to 100 mL;
the volume ratio of the mass of the tannic acid in the tannic acid solution to the deionized water in the step V is (1 g-2 g) to 100 mL;
fifthly, repeating the fifth step for 20-40 times to obtain a composite ceramic block coated with the coating;
thirdly, placing the composite ceramic block coated with the coating in epigallocatechin gallate solution for 5-10 min, taking out and drying, then placing the ceramic block in tannic acid solution for soaking for 5-10 min, taking out and drying;
the volume ratio of the mass of the tannic acid in the tannic acid solution to the deionized water in the step five (1 g-2 g) is 100 mL;
the volume ratio of the mass of the epigallocatechin gallate in the epigallocatechin gallate solution to the deionized water is (0.001 g-0.01 g) 1 mL;
fourthly, repeating the fifth step and the third step for 20 to 40 times to obtain the anti-inflammatory tooth restoration material with the layer-by-layer self-assembly coating.
The principle and the advantages of the invention are as follows:
the preparation method comprises the steps of preparing an alumina and cerium dioxide toughened composite ceramic block by using sodium oleate as a dispersing agent, sodium carboxymethylcellulose and polyvinyl alcohol as binders, nano-zirconia powder as a raw material and nano-alumina powder and nano-cerium dioxide powder as toughening agents, and preparing a high-hardness coating on the surface of the alumina and cerium dioxide toughened composite ceramic block by using polyvinyl alcohol, tannic acid and epigallocatechin gallate as raw materials through a layer-by-layer self-assembly method, wherein the coating can prevent body fluid from permeating, and has anti-inflammation and is not easy to cause inflammation due to the fact that epigallocatechin gallate is contained;
the fracture toughness of the zirconia ceramic is 8 MPa.m1/2The fracture toughness of the anti-inflammatory tooth restoration material with the layer-by-layer self-assembly coating prepared by the invention can reach 16 MPa.m1/2~20MPa·m1/2Therefore, compared with zirconia ceramics, the fracture toughness of the anti-inflammatory tooth restoration material with the layer-by-layer self-assembly coating prepared by the invention is improved by 1-1.5 times.
Drawings
Fig. 1 is a digital photograph of an anti-inflammatory dental restoration material with a layer-by-layer self-assembled coating prepared in example one.
Detailed Description
The first embodiment is as follows: the method for manufacturing the anti-inflammatory tooth restoration material with the layer-by-layer self-assembly coating is completed according to the following steps:
firstly, uniformly mixing deionized water, sodium oleate, sodium carboxymethylcellulose and polyvinyl alcohol, and stirring to obtain a solution A;
the mass ratio of the deionized water to the sodium carboxymethyl cellulose in the first step is 100 (0.3-1);
the mass ratio of the deionized water to the polyvinyl alcohol in the first step is 100 (0.5-2);
the mass ratio of the deionized water to the sodium oleate in the first step is 100 (1.5-2);
secondly, adding nano zirconia powder, nano alumina powder and nano cerium dioxide powder into the solution A, and stirring to obtain slurry;
the mass ratio of the nano zirconia powder, the nano alumina powder and the nano ceria powder in the second step is 100 (4-8) to (8-15);
the mass ratio of the solution A to the nano zirconia powder in the step two is 100 (10-20);
thirdly, carrying out spray granulation on the slurry in a spray granulator, and pressing the obtained particles to obtain a ceramic block;
the thickness of the porcelain block in the third step is 15 mm-30 mm;
the pressing pressure in the third step is 80MPa to 150 MPa;
fourthly, placing the porcelain block into a muffle furnace, heating to 250-300 ℃ at a heating rate of 2-4 ℃/min, then preserving heat at 250-300 ℃ for 2-4 h, heating from 250-300 ℃ to 750-800 ℃ at a heating rate of 2-4 ℃/min, then preserving heat at 750-800 ℃ for 2-3 h, heating from 750-800 ℃ to 1500-1560 ℃ at a heating rate of 2-4 ℃/min, and then preserving heat at 1500-1560 ℃ for 1-2 h; obtaining a composite ceramic block toughened by alumina and cerium dioxide;
fifthly, self-assembling layer by layer:
firstly, immersing the composite ceramic block toughened by the alumina and the cerium dioxide into a polyvinyl alcohol solution for 5-10 min, taking out and drying; then placing the mixture into a tannic acid solution for soaking for 5min to 10min, taking out and drying;
the volume ratio of the mass of the polyvinyl alcohol in the polyvinyl alcohol solution in the step V to the deionized water is (1 g-2 g) to 100 mL;
the volume ratio of the mass of the tannic acid in the tannic acid solution to the deionized water in the step V is (1 g-2 g) to 100 mL;
fifthly, repeating the fifth step for 20-40 times to obtain a composite ceramic block coated with the coating;
thirdly, placing the composite ceramic block coated with the coating in epigallocatechin gallate solution for 5-10 min, taking out and drying, then placing the ceramic block in tannic acid solution for soaking for 5-10 min, taking out and drying;
the volume ratio of the mass of the tannic acid in the tannic acid solution to the deionized water in the step five (1 g-2 g) is 100 mL;
the volume ratio of the mass of the epigallocatechin gallate in the epigallocatechin gallate solution to the deionized water is (0.001 g-0.01 g) 1 mL;
fourthly, repeating the fifth step and the third step for 20 to 40 times to obtain the anti-inflammatory tooth restoration material with the layer-by-layer self-assembly coating.
The second embodiment is as follows: the present embodiment differs from the present embodiment in that: the grain diameter of the nano zirconia powder in the second step is 20 nm-40 nm. Other steps are the same as in the first embodiment.
The third concrete implementation mode: the present embodiment differs from the first or second embodiment in that: the grain size of the nano alumina powder in the second step is 40 nm-60 nm. The other steps are the same as in the first or second embodiment.
The fourth concrete implementation mode: the difference between this embodiment and one of the first to third embodiments is as follows: the particle size of the nano cerium dioxide powder in the second step is 40 nm-60 nm. The other steps are the same as those in the first to third embodiments.
The fifth concrete implementation mode: the difference between this embodiment and one of the first to fourth embodiments is: the particle size of the particles obtained by spray granulation in the third step is 10-30 μm. The other steps are the same as those in the first to fourth embodiments.
The sixth specific implementation mode: the difference between this embodiment and one of the first to fifth embodiments is as follows: the atomization frequency of the spray granulation in the third step is 200Hz, the rotating speed of a feed pump is 30r/min, and the drying temperature is 220-300 ℃. The other steps are the same as those in the first to fifth embodiments.
The seventh embodiment: the difference between this embodiment and one of the first to sixth embodiments is: the pressing pressure in the third step is 80MPa to 100 MPa. The other steps are the same as those in the first to sixth embodiments.
The specific implementation mode is eight: the difference between this embodiment and one of the first to seventh embodiments is: putting the porcelain block into a muffle furnace, heating to 280 ℃ at the heating rate of 3 ℃/min, then preserving heat for 3h at 280 ℃, heating from 280 ℃ to 800 ℃ at the heating rate of 3 ℃/min, then preserving heat for 2h at 800 ℃, heating from 800 ℃ to 1550 ℃ at the heating rate of 3 ℃/min, and then preserving heat for 1.5h at 1550 ℃; and obtaining the composite ceramic block. The other steps are the same as those in the first to seventh embodiments.
The specific implementation method nine: the difference between this embodiment and the first to eighth embodiments is: fifthly, repeating the fifth step for 30-40 times to obtain the composite ceramic block coated with the coating; and in the step V, repeating the step V and the step V for 30 to 40 times to obtain the anti-inflammatory tooth restoration material with the layer-by-layer self-assembly coating. The other steps are the same as those in the first to eighth embodiments.
The detailed implementation mode is ten: the difference between this embodiment and one of the first to ninth embodiments is as follows: the volume ratio of the weight of the epigallocatechin gallate in the epigallocatechin gallate solution to the deionized water is (0.005 g-0.008 g):1 mL. The other steps are the same as those in the first to ninth embodiments.
The following examples were used to demonstrate the beneficial effects of the present invention:
the first embodiment is as follows: a method for manufacturing an anti-inflammatory tooth restoration material with a layer-by-layer self-assembly coating is completed according to the following steps:
firstly, uniformly mixing deionized water, sodium oleate, sodium carboxymethylcellulose and polyvinyl alcohol, and stirring to obtain a solution A;
the mass ratio of the deionized water to the sodium carboxymethyl cellulose in the first step is 100: 0.6;
the mass ratio of the deionized water to the polyvinyl alcohol in the first step is 100: 1.2;
the mass ratio of the deionized water to the sodium oleate in the step one is 100: 1.8;
secondly, adding nano zirconia powder, nano alumina powder and nano cerium dioxide powder into the solution A, and stirring to obtain slurry;
the grain diameter of the nano zirconia powder in the step two is 20 nm-40 nm;
the grain size of the nano alumina powder in the second step is 40 nm-60 nm;
the particle size of the nano cerium dioxide powder in the second step is 40 nm-60 nm;
the mass ratio of the nano zirconia powder, the nano alumina powder and the nano ceria powder in the step two is 100:6: 10;
the mass ratio of the solution A to the nano zirconia powder in the step two is 100: 15;
thirdly, carrying out spray granulation on the slurry in a spray granulator, and pressing the obtained particles to obtain a ceramic block;
the particle size of the particles obtained by spray granulation in the third step is 10-15 mu m;
the thickness of the porcelain block in the third step is 20 mm;
the atomization frequency of the spray granulation in the third step is 200Hz, the rotating speed of a feed pump is 30r/min, and the drying temperature is 300 ℃;
the pressing pressure in the third step is 90 MPa;
fourthly, placing the porcelain block into a muffle furnace, heating to 280 ℃ at a heating rate of 3 ℃/min, then preserving heat at 280 ℃ for 3h, heating from 280 ℃ to 800 ℃ at a heating rate of 3 ℃/min, then preserving heat at 800 ℃ for 2h, heating from 800 ℃ to 1550 ℃ at a heating rate of 3 ℃/min, and then preserving heat at 1550 ℃ for 1.5 h; obtaining a composite ceramic block toughened by alumina and cerium dioxide;
fifthly, self-assembling layer by layer:
firstly, immersing the alumina and cerium dioxide toughened composite ceramic block into a polyvinyl alcohol solution for 10min, taking out and drying; then soaking in tannic acid solution for 10min, taking out and drying;
the volume ratio of the mass of the polyvinyl alcohol in the polyvinyl alcohol solution in the fifth step to the deionized water is 1.5g:100 mL;
fifthly, the volume ratio of the mass of the tannic acid in the tannic acid solution to the deionized water is 1.5g to 100 mL;
fifthly, repeating the step five and the step 30 times to obtain a composite ceramic block coated with the coating;
thirdly, placing the composite ceramic block coated with the coating in epigallocatechin gallate solution for 10min, taking out and drying, then placing the ceramic block in tannic acid solution for 10min, taking out and drying;
the volume ratio of the mass of the epigallocatechin gallate in the epigallocatechin gallate solution in the fifth step to the deionized water is 0.006g:1 mL;
fifthly, the volume ratio of the mass of the tannic acid in the tannic acid solution to the deionized water is 1.5g to 100 mL;
fourthly, repeating the fifth step and the third step for 30 times to obtain the anti-inflammatory tooth restoration material with the layer-by-layer self-assembly coating.
Example one prepared anti-inflammatory dental restoration material with a layer-by-layer self-assembled coating has a fracture toughness of up to 20MPa · m1/2
Example two: the present embodiment is different from the first embodiment in that: and the mass ratio of the nano zirconia powder, the nano alumina powder and the nano ceria powder in the step two is 100:4: 8. Other steps and parameters are the same as those in the first embodiment.
The fracture toughness of the anti-inflammatory tooth restoration material with the layer-by-layer self-assembly coating prepared in the second embodiment can reach 16.9 MPa.m1/2
Example three: the present embodiment is different from the first embodiment in that: in the fourth step, the porcelain block is put into a muffle furnace, the temperature is raised to 250 ℃ at the heating rate of 4 ℃/min, then the heat is preserved for 2h at 250 ℃, the temperature is raised from 250 ℃ to 780 ℃ at the heating rate of 4 ℃/min, then the heat is preserved for 3h at 780 ℃, the temperature is raised from 780 ℃ to 1500 ℃ at the heating rate of 4 ℃/min, and then the heat is preserved for 2h at 1500 ℃. And obtaining the alumina and cerium dioxide toughened composite ceramic block. Other steps and parameters are the same as those in the first embodiment.
The fracture toughness of the anti-inflammatory tooth restoration material with the layer-by-layer self-assembly coating prepared in the third embodiment can reach 18.3 MPa.m1/2
Comparative example: the zirconia ceramic is prepared by the following steps:
firstly, adding nano zirconia powder into deionized water, and stirring to obtain slurry;
the particle size of the nano zirconia powder in the step one is 20 nm-40 nm;
the mass ratio of the deionized water to the nano zirconia powder in the first step is 100: 15;
secondly, carrying out spray granulation on the slurry in a spray granulator, and pressing the obtained particles to obtain a ceramic block;
the particle size of the particles obtained by spray granulation in the second step is 10-15 μm;
the thickness of the porcelain block in the second step is 20 mm;
the atomization frequency of the spray granulation in the step two is 200Hz, the rotating speed of a feed pump is 30r/min, and the drying temperature is 300 ℃;
the pressing pressure in the step two is 90 MPa;
thirdly, placing the porcelain block into a muffle furnace, heating to 280 ℃ at a heating rate of 3 ℃/min, then preserving heat at 280 ℃ for 3h, heating from 280 ℃ to 800 ℃ at a heating rate of 3 ℃/min, then preserving heat at 800 ℃ for 2h, heating from 800 ℃ to 1550 ℃ at a heating rate of 3 ℃/min, and then preserving heat at 1550 ℃ for 1.5 h; obtaining the zirconia ceramics.
The fracture toughness of the zirconia ceramics prepared by the comparative example can reach 8 MPa.m1/2
Fig. 1 is a digital photograph of an anti-inflammatory dental restoration material with a layer-by-layer self-assembled coating prepared in example one.
The anti-inflammatory dental restoration materials having layer-by-layer self-assembled coatings prepared in examples one, two and three did not cause oral inflammation as dental restoration materials.
The thicknesses of the anti-inflammatory dental restoration materials having a layer-by-layer self-assembled coating prepared in examples one, two and three as dental restorations are listed in table 1.
TABLE 1
Examples Thickness/mm
Example one 0.29mm~0.64mm
Example two 0.33mm~0.82mm
EXAMPLE III 0.32mm~0.79mm

Claims (10)

1. A method for manufacturing an anti-inflammatory tooth restoration material with a layer-by-layer self-assembly coating is characterized in that the method for manufacturing the anti-inflammatory tooth restoration material with the layer-by-layer self-assembly coating is completed according to the following steps:
firstly, uniformly mixing deionized water, sodium oleate, sodium carboxymethylcellulose and polyvinyl alcohol, and stirring to obtain a solution A;
the mass ratio of the deionized water to the sodium carboxymethyl cellulose in the first step is 100 (0.3-1);
the mass ratio of the deionized water to the polyvinyl alcohol in the first step is 100 (0.5-2);
the mass ratio of the deionized water to the sodium oleate in the first step is 100 (1.5-2);
secondly, adding nano zirconia powder, nano alumina powder and nano cerium dioxide powder into the solution A, and stirring to obtain slurry;
the mass ratio of the nano zirconia powder, the nano alumina powder and the nano ceria powder in the second step is 100 (4-8) to (8-15);
the mass ratio of the solution A to the nano zirconia powder in the step two is 100 (10-20);
thirdly, carrying out spray granulation on the slurry in a spray granulator, and pressing the obtained particles to obtain a ceramic block;
the thickness of the porcelain block in the third step is 15 mm-30 mm;
the pressing pressure in the third step is 80MPa to 150 MPa;
fourthly, placing the porcelain block into a muffle furnace, heating to 250-300 ℃ at a heating rate of 2-4 ℃/min, then preserving heat at 250-300 ℃ for 2-4 h, heating from 250-300 ℃ to 750-800 ℃ at a heating rate of 2-4 ℃/min, then preserving heat at 750-800 ℃ for 2-3 h, heating from 750-800 ℃ to 1500-1560 ℃ at a heating rate of 2-4 ℃/min, and then preserving heat at 1500-1560 ℃ for 1-2 h; obtaining a composite ceramic block toughened by alumina and cerium dioxide;
fifthly, self-assembling layer by layer:
firstly, immersing the composite ceramic block toughened by the alumina and the cerium dioxide into a polyvinyl alcohol solution for 5-10 min, taking out and drying; then placing the mixture into a tannic acid solution for soaking for 5min to 10min, taking out and drying;
the volume ratio of the mass of the polyvinyl alcohol in the polyvinyl alcohol solution in the step V to the deionized water is (1 g-2 g) to 100 mL;
the volume ratio of the mass of the tannic acid in the tannic acid solution to the deionized water in the step V is (1 g-2 g) to 100 mL;
fifthly, repeating the fifth step for 20-40 times to obtain a composite ceramic block coated with the coating;
thirdly, placing the composite ceramic block coated with the coating in epigallocatechin gallate solution for 5-10 min, taking out and drying, then placing the ceramic block in tannic acid solution for soaking for 5-10 min, taking out and drying;
the volume ratio of the mass of the tannic acid in the tannic acid solution to the deionized water in the step five (1 g-2 g) is 100 mL;
the volume ratio of the mass of the epigallocatechin gallate in the epigallocatechin gallate solution to the deionized water is (0.001 g-0.01 g) 1 mL;
fourthly, repeating the fifth step and the third step for 20 to 40 times to obtain the anti-inflammatory tooth restoration material with the layer-by-layer self-assembly coating.
2. The method for preparing an anti-inflammatory dental restoration material having a layer-by-layer self-assembled coating as claimed in claim 1, wherein the nano zirconia powder in step two has a particle size of 20nm to 40 nm.
3. The method for producing an anti-inflammatory dental restoration material having a layer-by-layer self-assembled coating as claimed in claim 1, wherein the nano alumina powder in step two has a particle size of 40nm to 60 nm.
4. The method for preparing an anti-inflammatory dental restoration material having a layer-by-layer self-assembled coating as claimed in claim 1, wherein the nano-ceria powder in step two has a particle size of 40nm to 60 nm.
5. The method for preparing an anti-inflammatory dental restoration material having a layer-by-layer self-assembled coating according to claim 1, wherein the spray granulation in step three is carried out to obtain particles having a particle size of 10 μm to 30 μm.
6. The method for preparing an anti-inflammatory dental restoration material having a layer-by-layer self-assembled coating according to claim 1, wherein the spray granulation in step three has an atomization frequency of 200Hz, a feed pump rotation speed of 30r/min, and a drying temperature of 220 ℃ to 300 ℃.
7. The method for preparing an anti-inflammatory dental restoration material having a layer-by-layer self-assembled coating according to claim 1, wherein the pressing pressure in step three is 80MPa to 100 MPa.
8. The method for preparing an anti-inflammatory dental restoration material with a layer-by-layer self-assembled coating according to claim 1, wherein the fourth step comprises placing the ceramic block in a muffle furnace, heating to 280 ℃ at a heating rate of 3 ℃/min, maintaining the temperature at 280 ℃ for 3 hours, heating from 280 ℃ to 800 ℃ at a heating rate of 3 ℃/min, maintaining the temperature at 800 ℃ for 2 hours, heating from 800 ℃ to 1550 ℃ at a heating rate of 3 ℃/min, and maintaining the temperature at 1550 ℃ for 1.5 hours to obtain the alumina and ceria toughened composite ceramic block.
9. The method for producing an anti-inflammatory dental restoration material having a layer-by-layer self-assembled coating according to claim 1, wherein the step five (c) is repeated 30 to 40 times to obtain a composite ceramic block coated with a coating; and in the step V, repeating the step V and the step V for 30 to 40 times to obtain the anti-inflammatory tooth restoration material with the layer-by-layer self-assembly coating.
10. The method for preparing an anti-inflammatory tooth restoration material with a layer-by-layer self-assembly coating according to claim 1, wherein the volume ratio of the weight of epigallocatechin gallate in the epigallocatechin gallate solution in the step (fifty) to deionized water is (0.005 g-0.008 g):1 mL.
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