CN112138134A - A Chinese medicinal patch for treating gynecological diseases and its preparation method - Google Patents

Abstract

The invention discloses a periodic traditional Chinese medicine application for treating gynecopathy, which comprises the following raw materials in parts by weight: 6-18 parts of glossy privet fruit, 9-18 parts of semen cuscutae, 6-15 parts of rhizoma polygonati, 6-18 parts of herba epimedii and 2-12 parts of cassia twig or cinnamon. The preparation method of the cycle-by-cycle traditional Chinese medicine application for treating gynecological diseases comprises the following steps: (1) weighing the raw materials according to the parts by weight of the periodic Chinese medicinal plaster for treating the gynecological diseases; (2) mixing the raw materials except the ginger juice, grinding, and sieving to obtain mixed medicinal powder; (3) mixing the mixed medicinal powder with ginger juice, and pressing into medicinal cake to obtain the Chinese medicinal patch. The traditional Chinese medicine plaster can be applied according to different symptoms before and after ovulation, can avoid stimulation and toxic and side effects of oral medicines on the stomach, has double treatment effects of percutaneous absorption of the medicines and stimulation of meridian points, and is remarkable in curative effect, low in side effect and convenient to use.

Description

A kind of periodic traditional Chinese medicine applicator for treating gynecological diseases and preparation method thereof

technical field

The invention relates to the technical field of traditional Chinese medicines, in particular to a periodical traditional Chinese medicine patch for treating gynecological diseases and a preparation method thereof.

Background technique

Women have the physiological characteristics of menstruation, belt, fetus, and birth. Kidney, Tiangui, Chongren, and uterus regulate each other, and under the coordination of viscera, meridians, qi and blood, the uterus regularly stores and purifies, and menstruation is carried out according to the month. In the menstrual cycle, the ebb and flow of yin, yang, qi and blood has both overall and periodic rhythm changes to maintain female reproductive function. Under normal circumstances, along with the ebb and flow of qi, blood, yin and yang in the menstrual cycle, the ovaries, endometrium, breast, uterus, cervical mucus, and fallopian tubes also undergo periodic changes. , can cause infertility, follicular development disorder, ovulation disorder, irregular menstruation, oligomenorrhea, metrorrhagia, intermenstrual bleeding, prolonged menstrual period, late menstrual period, amenorrhea, thin endometrium, thick endometrium, Under the disease, polycystic ovary syndrome, endometriosis, adenomyosis, uterine fibroids, tubal obstruction, breast addiction and other diseases. Traditional Chinese medicine believes that various factors such as cold and dampness pathogens, emotional factors such as anger, thinking, and fear, life factors, blood stasis, phlegm-drinking and other factors can lead to the occurrence of gynecological diseases. Traditional Chinese medicine believes that the menstrual cycle is divided into four periods: menstrual period, postmenstrual period, intermenstrual period, and premenstrual period; modern medicine believes that menstruation is divided into menstrual period (corresponding to TCM menstrual period), follicular phase (corresponding to postmenstrual period), and ovulation period (corresponding to the intermenstrual period), luteal phase (corresponding to the premenstrual period), although the names of Chinese and Western medicine stages are different, the understanding of the regularity of each period of the menstrual cycle is unified.

At present, the Chinese patent application number 2013102301780 discloses a traditional Chinese medicine patch for the treatment of dysmenorrhea; the Chinese patent application number 201610215510X discloses a traditional Chinese medicine preparation for the treatment of fallopian tube obstruction, but these patents do not follow the physiological characteristics of women in different stages of menstruation Medication. The treatment of gynecological diseases should be intervened according to different treatment principles in different stages of the menstrual cycle. Only by nourishing the yin and strengthening the spleen in the postmenstrual period and warming the kidney and removing blood stasis in the premenstrual period can good results be achieved.

Therefore, how to provide a traditional Chinese medicine for different stages of the menstrual cycle is an urgent problem for those skilled in the art.

SUMMARY OF THE INVENTION

In view of this, the present invention provides a safe, effective and no side effect traditional Chinese medicine patch for different stages of the menstrual cycle.

In order to achieve the above object, the present invention adopts the following technical scheme: a kind of sub-periodic traditional Chinese medicine patch for the treatment of gynecological diseases, comprising the following raw materials in parts by weight:

Ligustrum lucidum 6-18 parts, dodder 9-18 parts, Polygonatum 6-15 parts, Epimedium 6-18 parts, Cinnamon sticks or cinnamon 2-12 parts, Ginger juice 20-40 parts.

Beneficial effects of the present invention: the traditional Chinese medicine patch in the present invention can avoid the stimulation and toxic side effects of oral medicines on the stomach tract, and has the dual therapeutic effects of drug percutaneous absorption and stimulation of meridian points, significant curative effect, low side effects, and convenient use.

Preferably, when choosing Guizhi, the following raw materials are also included in parts by weight: 6-15 parts of Angelica sinensis, 6-18 parts of raspberry, 6-18 parts of Morinda officinalis, and 9-18 parts of Chinese yam.

Preferably, it includes the following raw materials in parts by weight: 12-15 parts of Ligustrum lucidum, 9-15 parts of Dodder Seed, 12-15 parts of Polygonatum chinensis, 9-15 parts of Epimedium, 3-6 parts of Cinnamon Root, 9-15 parts of Angelica sinensis servings, 6-9 servings of raspberries, 9-12 servings of Morinda officinalis, 9-12 servings of yam, and 20-40 servings of ginger juice.

The technical effect of adopting the above scheme: the above scheme is a traditional Chinese medicine patch used before ovulation; wherein, Ligustrum lucidum, Rhizoma Polygonatum, Angelica sinensis, nourishing yin and blood are the monarchs, Chinese yam, dodder, raspberry, tonifying the kidney and strengthening the spleen are the ministers, Morinda officinalis, Epimedium warms the kidney and yang as the auxiliary, and the cinnamon stick and ginger juice warms the meridians and dispels the cold, and has the effect of nourishing the yin, invigorating the spleen and nourishing the blood.

Preferably, when selecting cinnamon, it also includes the following raw materials in parts by weight: 6-15 parts of white peony root, 5-15 parts of zelan, 6-12 parts of Eucommia ulmoides, 3-12 parts of Salvia miltiorrhiza, 2-15 parts of Vinegar Cyperus .

Preferably, it includes the following raw materials in parts by weight: 6-12 parts of Ligustrum lucidum, 12-15 parts of dodder, 9-12 parts of Polygonatum chinensis, 9-12 parts of Epimedium, 3-6 parts of cinnamon, 6-9 parts of Paeonia lactiflora parts, 5-9 parts of Zelan, 6-9 parts of Eucommia ulmoides, 3-6 parts of Salvia miltiorrhiza, 2-12 parts of Vinegar Cymbidium, and 20-40 parts of ginger juice.

The technical effect of adopting the above scheme: the above scheme is a traditional Chinese medicine patch used after ovulation, wherein, Dodder, Epimedium, Eucommia ulmoides and Eucommia are the monarchs, white peony root and cinnamon nourish the blood and warm the meridians are the ministers, Polygonatum chinensis, Ligustrum lucidum nourishing Invigorating the yin of the kidney is the accompaniment, and the zelan and salvia vinegar fragrant and fragrant herbs are also assisted to remove blood stasis and regulate the menstruation.

The invention also discloses a preparation method of a periodic traditional Chinese medicine patch for treating gynecological diseases, comprising the following steps:

(1) each raw material is weighed according to the parts by weight of the cyclical Chinese medicine patch for the treatment of gynecological diseases;

(2) mixing raw materials except ginger juice, then grinding, sieving to obtain mixed medicinal powder;

(3) mixing the mixed medicinal powder and ginger juice, and then pressing into medicinal cakes to obtain the traditional Chinese medicine patch.

The preparation method of the invention is simple, and the raw materials used are widely available and easily available, and can be suitable for large-scale industrial production.

Preferably, in step (2), the mesh number of the sieving is 60-80 mesh.

Preferably, in step (3), the size of the medicine cake is 2.0cm×2.0cm, and the thickness is 1.5cm.

The traditional Chinese medicine patch in the present invention is used for the application of acupoints, and the method of acupoint application belongs to one of the contents of acupuncture and moxibustion. Based on the theory of traditional Chinese medicine meridians and collaterals, the medicine is ground into fine powder, and the paste is applied with an appropriate solvent. It is an external treatment method for treating diseases on specific acupoints, which integrates the knowledge of meridian and acupoints and traditional Chinese medicine, and is safe, effective and free of side effects.

As can be seen from the above-mentioned technical solutions, compared with the prior art, the present invention discloses and provides a periodic traditional Chinese medicine patch for treating gynecological diseases, and the beneficial effects are as follows:

1, the traditional Chinese medicine sticking in the present invention adopts acupoint sticking treatment, can avoid the gastrointestinal stimulation and toxic and side effects of oral medicine, has the dual therapeutic effect of drug percutaneous absorption and stimulation of meridian points, small points have large effects, and the curative effect is remarkable, It has low side effects and is easy to use.

2. The traditional Chinese medicine applicator of the present invention treats gynecological diseases. According to different drug characteristics in different stages of the menstrual cycle, it is divided into two sticking prescriptions. Too little, thin endometrium, premature ovarian failure, polycystic ovary syndrome, secondary amenorrhea, intermenstrual bleeding, prolonged menstrual period, metrorrhagia, breast addiction, adenomyosis, dysmenorrhea, endometriosis , assisted reproductive stage of thin endometrial, follicular development disorders, poor egg quality, poor endometrial receptivity and other diseases; according to the different stages of the menstrual cycle, the drug is applied according to the different stages of the menstrual cycle, and the change law of qi, blood, yin and yang is followed, and the clinical effect is significant and the total effective rate High, can improve endometrial thickness, egg quality, promote follicle development, fertility, menstrual regulation (including menstrual volume, menstrual period, etc.), relieve pain and other clinical symptoms.

3. The composition and proportion of the traditional Chinese medicine prescription of the present invention are obtained through clinical screening, and are specially applied for gynecological diseases, and have the advantages of good curative effect and remarkable effect.

Detailed ways

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

Example 1

The raw materials of the periodic traditional Chinese medicine patch for treating gynecological diseases: Angelica 9g, Ligustrum lucidum 12g, Dodder 12g, raspberry 9g, Morinda officinalis 9g, Chinese yam 9g, Polygonatum 12g, Epimedium 12g, Guizhi 5g, Ginger juice 20g -40g.

The preparation method of above-mentioned Chinese medicine patch: (1) each raw material is weighed according to the weight of the above-mentioned treatment of gynecological diseases by the weight of the periodical Chinese medicine patch;

(2) mixing the raw materials except the ginger juice, then grinding, 60 mesh sieves are crossed to obtain mixed medicinal powder;

(3) mixing the mixed medicinal powder and ginger juice, and then pressing into a medicinal cake to obtain a traditional Chinese medicine patch; wherein, the medicinal cake has a size of 2.0cm×2.0cm and a thickness of 1.5cm.

Example 2

The raw materials of the periodic traditional Chinese medicine patch for treating gynecological diseases: Angelica 6g, Ligustrum lucidum 12g, Dodder 12g, raspberry 6g, Morinda officinalis 9g, Chinese yam 9g, Polygonatum 15g, Epimedium 12g, Guizhi 5g, Ginger juice 20g -40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 3

The raw materials of the traditional Chinese medicine patch for the treatment of gynecological diseases: 9g Angelica sinensis, 15g Ligustrum lucidum, 15g Dodder, 6g raspberry, 9g Morinda officinalis, 9g Chinese yam, 12g Polygonatum chinensis, 12g Epimedium, 3g Guizhi, 20g ginger juice -40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 4

The raw materials of the periodic traditional Chinese medicine patch for treating gynecological diseases: Angelica 9g, Ligustrum lucidum 9g, Dodder 15g, raspberry 9g, Morinda officinalis 6g, Chinese yam 9g, Polygonatum 12g, Epimedium 9g, Guizhi 3g, Ginger juice 20g -40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 5

The raw materials of the periodic traditional Chinese medicine patch for treating gynecological diseases: Angelica 12g, Ligustrum lucidum 9g, Dodder 15g, raspberry 9g, Morinda officinalis 6g, Chinese yam 9g, Polygonatum 12g, Epimedium 9g, Guizhi 3g, Ginger juice 20g -40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 6

The raw materials of the periodic traditional Chinese medicine patch for the treatment of gynecological diseases: Angelica 12g, Ligustrum lucidum 15g, Dodder 12g, raspberry 9g, Morinda officinalis 6g, Chinese yam 9g, Polygonatum 15g, Epimedium 9g, Guizhi 2g, Ginger juice 20g -40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 7

The raw materials of the periodic traditional Chinese medicine patch for treating gynecological diseases: Angelica 12g, Ligustrum lucidum 9g, Dodder 12g, raspberry 6g, Morinda officinalis 6g, Chinese yam 15g, Polygonatum 15g, Epimedium 6g, Guizhi 2g, Ginger juice 20g -40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 8

The raw materials of the periodic traditional Chinese medicine patch for the treatment of gynecological diseases: Angelica 15g, Ligustrum lucidum 9g, Dodder 15g, raspberry 6g, Morinda officinalis 6g, Chinese yam 9g, Polygonatum 9g, Epimedium 6g, Guizhi 2g, Ginger juice 20g -40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 9

The raw materials of the periodic traditional Chinese medicine patch for treating gynecological diseases: Angelica 9g, Ligustrum lucidum 9g, Dodder 18g, raspberry 6g, Morinda officinalis 6g, Chinese yam 6g, Polygonatum 9g, Epimedium 12g, Guizhi 2g, Ginger juice 20g -40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 10

The raw materials of the periodic traditional Chinese medicine patch for treating gynecological diseases: Dodder 12g, Paeonia lactiflora 6g, Polygonatum 9g, Zelan 5g, Epimedium 15g, Eucommia 6g, Ligustrum lucidum 9g, Salvia miltiorrhiza 5g, Cinnamon 3g, Vinegar Fructus 2g, Ginger juice 20-40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 11

The raw materials of the periodic traditional Chinese medicine patch for the treatment of gynecological diseases: Dodder 12g, Paeonia lactiflora 6g, Polygonatum 9g, Zelan 9g, Epimedium 12g, Eucommia ulmoides 12g, Ligustrum lucidum 9g, Salvia miltiorrhiza 9g, Cinnamon 3g, Vinegar Fructus 5g, Ginger juice 20-40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 12

The raw materials of the periodic traditional Chinese medicine patch for the treatment of gynecological diseases: Dodder 15g, Paeonia lactiflora 6g, Polygonatum 9g, Zelan 3g, Epimedium 12g, Eucommia 9g, Ligustrum lucidum 9g, Salvia miltiorrhiza 3g, Cinnamon 3g, Vinegar Fructus 2g, Ginger juice 20-40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 13

The raw materials of the periodic traditional Chinese medicine patch for the treatment of gynecological diseases: Dodder 9g, Paeonia lactiflora 6g, Polygonatum 9g, Zelan 6g, Epimedium 15g, Eucommia 9g, Ligustrum lucidum 9g, Salvia miltiorrhiza 3g, Cinnamon 3g, Vinegar Fructus 3g, Ginger juice 20-40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 14

The raw materials of the periodic traditional Chinese medicine patch for treating gynecological diseases: Dodder 12g, Paeonia lactiflora 6g, Polygonatum 9g, Zelan 12g, Epimedium 12g, Eucommia 9g, Ligustrum lucidum 9g, Salvia miltiorrhiza 3g, Cinnamon 3g, Vinegar Fructus 6g, Ginger juice 20-40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 15

The raw materials of the periodic traditional Chinese medicine patch for the treatment of gynecological diseases: Dodder 12g, Paeonia lactiflora 9g, Polygonatum 9g, Zelan 6g, Epimedium 15g, Eucommia ulmoides 6g, Ligustrum lucidum 6g, Salvia miltiorrhiza 3g, Cinnamon 3g, Vinegar Fructus 3g, Ginger juice 20-40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 16

The raw materials of the periodic traditional Chinese medicine patch for the treatment of gynecological diseases: Dodder 12g, Paeonia lactiflora 6g, Polygonatum 9g, Zelan 12g, Epimedium 15g, Eucommia ulmoides 6g, Ligustrum lucidum 6g, Salvia miltiorrhiza 6g, Cinnamon 3g, Vinegar Fructus 6g, Ginger juice 20-40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 17

The raw materials of the periodic traditional Chinese medicine patch for the treatment of gynecological diseases: Dodder 12g, Paeonia lactiflora 6g, Polygonatum 9g, Zelan 12g, Epimedium 15g, Eucommia ulmoides 6g, Ligustrum lucidum 6g, Salvia miltiorrhiza 9g, Cinnamon 6g, Vinegar Fructus 12g, Ginger juice 20-40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Example 18

The raw materials of the periodic traditional Chinese medicine patch for treating gynecological diseases: Dodder 15g, Paeonia lactiflora 15g, Polygonatum 9g, Zelan 9g, Epimedium 12g, Eucommia ulmoides 6g, Ligustrum lucidum 6g, Salvia miltiorrhiza 3g, Cinnamon 3g, Vinegar Fructus 3g, Ginger juice 20-40g.

The preparation method of the above-mentioned traditional Chinese medicine patch is the same as that in Example 1.

Examples 1-9 are for pre-ovulation use and Examples 10-18 are for post-ovulation use.

According to the different characteristics of the disease, most diseases need one of the embodiments 1-9 combined with one of the embodiments 10-18, such as: infertility, follicular development disorder (including assisted reproduction stage), poor egg quality, menstruation too few, premature ovarian failure, polycystic ovary syndrome, secondary amenorrhea, prolonged menstrual period, breast addiction, adenomyosis, endometriosis; Examples 1-9 can also be used alone (such as: thin uterus Intima, metrorrhagia); 10-18 can be used alone (eg: dysmenorrhea, luteal insufficiency).

Performance Testing

Clinical observation on the treatment of gynecological diseases 1

1 Materials and methods

1.1 Research methods

46 patients with oligomenorrhea (thin endometrium) were subjected to a comparative analysis of symptoms before and after treatment. The specific implementation was as follows: the common symptoms of oligomenorrhea were planned, and the patients were scored for each symptom before treatment. Each symptom was scored, and the results were compared before and after treatment.

1.2 Research objects

A total of 46 patients with oligomenorrhea (thin endometrium) who visited the Department of Gynecology and Acupuncture and Moxibustion, Guoyitang Outpatient Department of Fujian University of Traditional Chinese Medicine from May 2018 to May 2020 were included and divided into 5 groups as the experimental group.

1.3 Drug preparation and use

The two groups of test groups used the patches prepared in Example 1, Example 2, Example 3, Example 4, and Example 5, respectively.

Application method: The patient is placed in a supine position, the application site is exposed, and a special dressing for three-volt moxibustion is used. The dressing cake is placed in the groove, and the dressing is attached to the selected acupoints. The 4th day of menstruation (taking 28 days of menstruation as an example) starts to apply, 3 times a week (once every other day), no application during menstruation, 20 minutes of drug application each time, local acupuncture points are irradiated with magic lamp infrared rays. 3 menstrual cycles are one course of treatment, and one course of treatment is applied according to the cycle.

Acupoint selection: Choose common acupoints in gynecology: Taixi (bilateral), Sanyinjiao (bilateral), Zusanli (bilateral), Guanyuan. Taixi is the original point of the Kidney Meridian of Foot Shaoyin, "kidney governs reproduction", Taixi has the effect of nourishing the Kidney Yin; Sanyinjiao Point is the point of the Spleen Meridian of Foot Taiyin, which can strengthen the spleen and blood, regulate the liver and kidney, and is the first choice for the treatment of gynecological diseases. ; Zusanli is the combined point of the stomach meridian of Foot Yangming, and the spleen and stomach are the source of qi and blood biochemistry. The combination of Zusanli and Sanyinjiao can promote the metaplasia of water and grains; It is recorded that Guanyuan is the acupoint of Renmai, which can regulate the local meridian Qi, and Guanyuan acupoint is a must-selected acupoint for clinical treatment of gynecological diseases.

1.4 Observation indicators

Symptoms: Lack of menstrual flow, dizziness, tinnitus, sore back, soft legs, heel pain or dizziness, palpitations, endometrial thickness

1.5 Auxiliary inspection

Endometrial thickness ≤7mm

1.6 Evaluation Criteria

Scoring standard: refer to the results of oligomenorrhea and auxiliary examinations in "Traditional Chinese Medicine and Gynecology", and the scoring table is as shown in Table 1 below:

Efficacy evaluation criteria: formulate with reference to "Traditional Chinese Medicine Disease Diagnosis Efficacy Criteria".

Efficacy index N=[(integration before treatment-integration after treatment)/integration before treatment]×100%;

Cured: N≥90% or endometrial thickness ≥7cm;

Improvement: 33.33%≤N<90% or endometrial thickness increased, but not ≥7cm;

Invalid: N < 33.33% or no change in intimal thickness.

2 Results of the study

2.1 Clinical efficacy

Table 2 adopts the clinical curative effect of embodiment 1-5

From above-mentioned table 2, it can be drawn that the treatment of gynecological diseases by periodical Chinese medicine applicator of the present invention has good clinical curative effect: can increase endometrial thickness, effectively improve menstrual flow, dizziness, tinnitus, sore waist, soft legs, heels. Pain or dizziness, palpitations.

Clinical observation of treating gynecological diseases 2

1 Materials and methods

1.1 Research methods

50 cases of polycystic ovary syndrome patients with follicular dysplasia were analyzed by treatment control. The specific implementation: after 1 course of sticking treatment, a comparison analysis before and after treatment was conducted.

1.2 Research objects

A total of 50 patients with polycystic ovary syndrome who were treated in the Department of Gynecology and Acupuncture and Moxibustion of the Outpatient Department of Guoyitang, Fujian University of Traditional Chinese Medicine from February 2018 to March 2020 were included and divided into 4 groups as the experimental group.

1.3 Drug preparation and use

The 4 groups of test groups used the patches prepared by combining Example 1 with Example 10, Example 2 with Example 11, Example 3 with Example 12, and Example 4 with Example 13.

Application method: The patients of Examples 1-9 were placed in a supine position, and the patients of Examples 10-18 were placed in a prone position, exposing the application site, using a special dressing for three-volt moxibustion, placing the dressing cake in the groove, and applying the dressing Paste it on the selected acupoint. The application was started on the fifth day of menstruation in Examples 1-9, and the application was started on the first day after ovulation in Examples 10-18, 3 times a week (once every other day), and no application was made during menstruation. Each time the drug is applied for 20 minutes, the acupoints are locally irradiated with magic lamp infrared rays. 3 menstrual cycles are one course of treatment, and one course of treatment is applied according to the cycle.

Acupoint selection: Ovary point, Sanyinjiao, Zusanli, Shenshu, Pishu, all points are applied on both sides. Ovary, Sanyinjiao, Zusanli before ovulation, Shenshu, Pishu, Yaoyangguan after ovulation (if the blood is confirmed to be pregnant, the application will be stopped). Ovary acupoint is the effective acupoint for treating follicular developmental disorders; Sanyinjiao acupoint is the acupoint of the spleen meridian of Foot Taiyin, which can strengthen the spleen and blood, regulate the liver and kidney, and is the first choice for the treatment of gynecological diseases; Zusanli point is the acupoint of the stomach meridian of Foot Yangming, the spleen and stomach. It is the source of qi and blood biochemistry. The combination of Zusanli and Sanyinjiao can promote the metaplasia of water and grains and promote the development of follicles; Shenshu and spleen and kidney points are the acupoints where the kidney and spleen essence are infused into the back and waist respectively. The combination of the two can warm the kidney. Invigorating the spleen; Yaoyangguan has the effect of warming the kidney and helping the yang.

1.4 Observation indicators

Menstrual volume, menstrual cycle, follicle development, basal body temperature, endometrial thickness, pregnancy, accompanying symptoms

1.5 Efficacy evaluation criteria

According to the 2013 edition of "Obstetrics and Gynecology" of the People's Medical Publishing House and related literature, it was compiled and drafted.

(1) Cured; the patient's follicles develop normally, the largest diameter in the late stage is greater than or equal to 18mm, the BBT is obviously biphasic, and the temperature difference fluctuates up to 0.3-0.5°C for 12-14 days; or the pregnancy is successful.

(2) Improvement: the maximum diameter of follicles at night is greater than or equal to 16mm but always less than 18mm; or the maximum diameter of follicles is greater than 18mm, but BBT is atypical biphasic; or symptoms and signs related to the disease have improved.

(3) Ineffective: after 3 months of treatment, the size of follicles, the main symptoms and signs and no improvement.

(4) Calculation of total effective rate: total effective rate = (number of cures + number of improvements)/number of participation statistics

2 Results of the study

2.1 Clinical efficacy

Table 3 adopts the clinical curative effect of the embodiment of the present invention combined with the treatment

From above-mentioned table 3, it can be drawn that the treatment of follicular dysplasia by the cyclical Chinese medicine application of the present invention has good clinical curative effect: can promote follicular development, regulate menstrual volume, regulate menstrual cycle, improve leucorrhea volume, waist and knees soreness and weakness. , fatigue and other related symptoms. The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments, and the same and similar parts between the various embodiments can be referred to each other. As for the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant part can be referred to the description of the method.

The above description of the disclosed embodiments enables any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (8)

1. a periodical Chinese medicine patch for the treatment of gynecological diseases, is characterized in that, comprises the raw material of following parts by weight: Ligustrum lucidum 6-18 parts, dodder 9-18 parts, Polygonatum 6-15 parts, Epimedium 6-18 parts, Cinnamon sticks or cinnamon 2-12 parts, Ginger juice 20-40 parts. 2. a kind of periodical Chinese medicine patch for the treatment of gynecological diseases according to claim 1, is characterized in that, when selecting cinnamon stick for use, also comprises the raw material of following parts by weight: 6-15 parts of Angelica sinensis, 6-15 parts of raspberry 18 servings, Morinda officinalis 6-18 servings, Chinese yam 9-18 servings. 3. a kind of periodical Chinese medicine patch for the treatment of gynecological diseases according to claim 2, is characterized in that, comprises the raw material of following parts by weight: 12-15 parts of Ligustrum lucidum, 9-15 parts of Cuscuta japonica, 12-15 parts of Polygonatum chinensis 15 parts, Epimedium 9-15 parts, Guizhi 3-6 parts, Angelica 9-15 parts, Raspberry 6-9 parts, Morinda officinalis 9-12 parts, Chinese yam 9-12 parts, Ginger juice 20-40 parts share. 4. a kind of periodical Chinese medicine patch for the treatment of gynecological diseases according to claim 1, is characterized in that, when selecting cinnamon, also comprises the raw material of following parts by weight: 6-15 parts of Paeonia lactiflora, 5-15 parts of Zelan 15 parts, 6-12 parts of Eucommia, 3-12 parts of Salvia, 2-15 parts of Vinegar Cyperus. 5. a kind of periodical Chinese medicine patch for the treatment of gynecological diseases according to claim 4, is characterized in that, comprises the raw material of following parts by weight: 6-12 parts of Ligustrum lucidum, 12-15 parts of Cuscuta japonica, 9-15 parts of Polygonatum chinensis 12 parts, Epimedium 9-12 parts, Cinnamon 3-6 parts, Paeonia lactiflora 6-9 parts, Zelan 5-9 parts, Eucommia ulmoides 6-9 parts, Salvia 3-6 parts, Vinegar Cyperus 2-12 parts , 20-40 servings of ginger juice. 6. a preparation method for the treatment of gynaecological diseases in cycles of traditional Chinese medicine patch, is characterized in that, comprises the following steps: (1) each raw material is weighed according to the parts by weight of the cyclical Chinese medicine patch for the treatment of gynecological diseases according to claim 1-5; (2) mixing raw materials except ginger juice, then grinding, sieving to obtain mixed medicinal powder; (3) mixing the mixed medicinal powder and ginger juice, and then pressing into medicinal cakes to obtain the traditional Chinese medicine patch. 7 . The cyclical Chinese medicine patch for treating gynecological diseases according to claim 6 , wherein in step (2), the mesh number of the sieving is 60-80 mesh. 8 . 8 . The cycle-by-cycle traditional Chinese medicine patch for treating gynecological diseases according to claim 6 , wherein, in step (3), the size of the medicine cake is 2.0cm×2.0cm, and the thickness is 1.5cm. 9 .