CN112107801A - Optical fiber probe for laser therapy - Google Patents
Optical fiber probe for laser therapy Download PDFInfo
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- CN112107801A CN112107801A CN202010547001.3A CN202010547001A CN112107801A CN 112107801 A CN112107801 A CN 112107801A CN 202010547001 A CN202010547001 A CN 202010547001A CN 112107801 A CN112107801 A CN 112107801A
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- diffuser
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00107—Coatings on the energy applicator
- A61B2018/00136—Coatings on the energy applicator with polymer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00321—Head or parts thereof
- A61B2018/00327—Ear, nose or throat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00333—Breast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00529—Liver
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00541—Lung or bronchi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2205—Characteristics of fibres
- A61B2018/2222—Fibre material or composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2244—Features of optical fibre cables, e.g. claddings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2255—Optical elements at the distal end of probe tips
- A61B2018/2261—Optical elements at the distal end of probe tips with scattering, diffusion or dispersion of light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S3/00—Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
- H01S3/005—Optical devices external to the laser cavity, specially adapted for lasers, e.g. for homogenisation of the beam or for manipulating laser pulses, e.g. pulse shaping
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Electromagnetism (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Radiation-Therapy Devices (AREA)
- Laser Surgery Devices (AREA)
Abstract
The invention relates to the technical field of medical treatment, in particular to a physiotherapy device for treating tumors by an invasive laser irradiation device. The probe comprises a fiber optic cable (1) with an optical fiber (2) inside, a polymer coating on the outside (3), a connection plug (4) at the proximal end of said cable (1), a laser diffuser at the distal end of said cable (1), a laser diffuser (5) made of a housing (6) made of quartz glass or a light conducting polymer, a light diffusing structural roughness (7) located on the inside and/or surface of said housing (6), the housing (6) having a polymer protective coating (8). Said diffuser (5) is cylindrical, 0.2-10cm long and 0.02-0.2cm in diameter, the nozzle diffuses light over its entire surface at an angle of 360 °, and the light penetration in the biological tissue from the diffuser surface reaches 2cm when the wavelength λ of the light is 670-; when the wavelength of light λ is 790-830nm, the penetration of light from the diffuser surface in biological tissue reaches 5 cm. The advantage of the probe and its diffuser nozzle is that it has a minimum size.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to a physiotherapy device for treating tumors by an invasive laser or optical irradiation device.
Background
A Laser Therapy Fiber Optic Probe (LTFOP) is an essential part of a laser therapy device to deliver a laser beam to a tumor. LTFOP is designed for its purpose: for non-invasive and/or invasive tumor irradiation. The shape of the LTFOP is selected based on the location of the tumor, the method of treatment, the light wave and intensity of the illuminating stream, the time of illumination, the use of supplemental photopharmaceuticals, and other parameters. In the case of invasive treatment, the LTFOP is inserted into the tumor via a catheter, cannula, or needle. The laser emits radiation through the LTFOP inserted into the tumor, destroying the tumor cells.
Different non-surgical non-invasive tumor treatment devices based on electrical, high frequency electromagnetic, ultrasound, infrared, UV-radiation, X-ray or radiation beam for destroying tumors are known, but the use of such treatments is limited due to low or excessive positive effects, such as irradiation.
Photosensitizers are introduced into the patient's circulatory system or directly into the tumor prior to laser irradiation, accumulate in the tumor formations, and help to more easily detect cells affected by cancer. The gradual dose irradiation by the laser beam does not damage healthy tissue but selectively destroys the tumor. When tumors are irradiated by LTFOP, the oxygen in the cells is converted from neutral to an activated state that acts cytotoxic on the tumor cells.
"magnetic laser therapy devices (LT 4113; A61N 2/00; A61N 5/06)" are known, including LTFOP lasers with interconvertible tips of different laser dose irradiation. The disadvantage of this device is that the tip is oversized and is not suitable for invasive tumour therapy.
A "fiber optic probe diffuser tip" (US 5269777; A61N5/06) "is known for use in laser treatment devices for irradiating invasive tumors. The diffuser tip has a silicone portion with desired light diffusing properties that is attached to the end of the optical fiber; a fiber optic housing and a silicone diffuser tip to ensure the desired rigidity and flexibility. The tip is cylindrical in shape and has a uniform distribution of radiation along its length. The drawback of the LTFOP probe and its tip is that its outer diameter is too large, requiring a catheter with a large inner and outer diameter to be introduced into the tumor being treated.
The closest known solution to the patentable invention is the "photodynamic therapy light diffuser" (US 6366719; A61B 18/22; A61N5/06), which emits light through a cylindrical surface. A diffuser formed by an optical fiber, or light emitting tip, delivers light radiation from the light emitting device to the irradiation site or body. The optical fibers are covered by a protective jacket within the cable. The ends of the optical fibers in the radiation diffuser are polished so that the light propagates uniformly through the polished section, creating a cylindrical flow of diffused light around, for example, a "bullet" diffuser. A disadvantage of this LTFOP and its tip (diffuser) is that the method of making the light diffuser is described, but the size and possibility of its introduction into the body and treatment is unclear.
Disclosure of Invention
It is an object of the present invention to provide a fiber optic probe (LTFOP) for diffuse invasive laser treatment with the best dimensions, i.e. with the thinnest possible outer diameter.
The patentable LTFOP comprises a fiber optic cable 1 with an optical fiber 2 inside, a polymer coating on the outside 3; a connection plug 4 at the proximal end of the cable and a laser emission tip (diffuser) 5 at the end of the cable, the laser diffuser tip (diffuser) 5 being formed by a housing 6 made of quartz glass or a light-conducting polymer, the housing 6 having light-diffusing structural irregularities (roughness) 7 on the inside and/or on the surface, and/or the housing 6 having or not having a protective coating 8 on the surface. The tip (diffuser) 5 is cylindrical, has a length of between 0.2 and 10cm, preferably between 0.5 and 3cm, and a diameter of between 0.02 and 0.2cm, and diffuses the laser light over its entire surface, i.e. its length and circumference at an angle of 360 °. When the wavelength of light lambda is 670-; when the wavelength of light λ is 790-830nm, the penetration of light from the tip (diffuser) surface in biological tissue can reach 5 cm.
When the light emitting tip (diffuser) 5 of the patentable LTFOP is 2-5cm long, the fiber 2 is made of a polymeric fiber, the light scattering angle is 360 °, the flux efficiency is at least 80%, and the tip (diffuser) 5 diameter is 0.05 cm; the length of the probe from the connection plug 4 to the light emission tip 5 is 30+15cm, the laser beam power is 400mW, and then the penetration of light in the biological tissue from the tip (diffuser) surface reaches 2cm when the light wavelength λ is 670-; when the wavelength of light λ is 790 and 830nm, the penetration of light from the tip (diffuser) surface in biological tissue reaches 5 cm.
When the patentable LTFOP has a light emission tip (diffuser) 5 that is 0.5-3cm long, the fiber 2 is made of silica glass, the light scattering angle is 360 °, the flux efficiency is at least 80%, and the tip (diffuser) 5 has a diameter of 0.1+0.02 cm; the probe has a length of 25+10cm from the connection plug 4 to the light emitting tip 5, a laser beam power of 1600mW, and then a penetration of light in the biological tissue from the tip (diffuser) surface of 2cm when the wavelength of light λ is 670-; when the wavelength of light λ is 790 and 830nm, the penetration of light from the tip (diffuser) surface in biological tissue reaches 5 cm.
The maximum power of the patentable LTFOP laser beam with fiber 2 and polymer tip (diffuser) 5 can be up to 500 mW; or the maximum power of the laser beam with the silica optical fiber 2 and the silica tip (diffuser) 5 can be 2000 mW.
The patentable LTFOP is sterile and suitable for use for 2 years from its date of manufacture.
Drawings
The invention is illustrated in FIG. 1, a schematic diagram of an LTFOP.
LTFOP includes:
an optical fiber cable 1;
an optical fiber 2;
a polymer coating 3;
a connection plug 4;
a light emission tip (diffuser) 5;
a tip housing 6 of light conductive material;
light scattering structural irregularities (roughness) 7;
a polymeric protective coating 8.
LTFOP was introduced and its operation was as follows:
the patient is administered the photosensitizer intravenously;
2-4 hours after injection of the photosensitizer, the tumor is measured by ultrasound to identify its actual location, i.e. the area and depth relative to the surface;
after marking the location of the tumor, local anesthesia is applied to the area where the catheter is to be inserted;
a catheter or plastic cannula with about 1.2 outer diameters of the inner diameter of the LTFOP is inserted into the tumor;
the LTFOP tip (diffuser) is inserted into the tumor through a catheter or cannula so that the light emitting tip (diffuser) 5 is as close to the tumor as possible or in a near-central position of the tumor;
the other end of the LTFOP is connected to a device via a connection plug 4, whereby laser beams having different wavelengths are generated;
determining the irradiation wavelength, the intensity (power) unit mW and the irradiation time unit minute, and turning on the laser;
the laser beam enters the laser diffusion tip (diffuser) 5 through the optical fiber 2 in the cable 1, where it is diffused at an angle of 360 ° throughout the entire length of the tip (diffuser) through irregularities and roughness 7 in the housing 6. At the end of the predetermined irradiation period, the irradiation process is terminated.
More than one catheter/cannula with inserted LTFOP may be used, as determined by the physician at the discretion. The power of the patentable LTFOP laser beam with polymer fiber 2 and polymer tip (diffuser) would not exceed 500 mW; and the maximum power of the laser beam having the quartz optical fiber 2 and the quartz tip (diffuser) does not exceed 2000 mW.
The irradiation process time was 20. + -.10 minutes.
Depending on the time of decomposition of the photosensitizer selected and the duration of tumor treatment, the process can be repeated for successive days, as determined by the physician at the discretion.
At the end of the process, LTFOP is removed and used according to established procedures.
By using patentable LTFOP, more effective, more uniform and larger area treatment of tumor exposure sites is achieved. A smaller amount of LTFOP can be used to irradiate the entire tumor area.
LTFOP can be used for the treatment of tumors in the lung, liver, thorax, and for non-invasive treatment of the nose, throat, ear, and genitals. Treatment was considered successful when the tumor size decreased after the irradiation period.
The laser wavelength described with reference to the patentable LTFOP may be different, however this does not change the essence of the invention.
With the patentable small LTFOP, the catheter puncture site heals more quickly, and multiple LTFOPs can be used simultaneously, thereby reducing the number and time of invasive treatments. Patentable LTFOP can be tested in patient treatment and positive results are obtained.
Claims (5)
1. A laser therapy fiber optic probe comprising a fiber optic cable having a switch at one end for connection to a laser device (laser), a laser emitting tip (diffuser) at the distal end of the fiber optic cable, characterized in that the laser therapy fiber optic probe comprises a fiber optic cable (1) having an optical fiber (2) inside, a polymer coating applied on the outside (3), at its proximal end, the laser cable has a connection plug (4), at its distal end, a laser emission tip (diffuser) (5), the laser diffuser tip (diffuser) 5 being formed by an outer shell (6) made of quartz glass or a light-conducting polymer, the shell (6) having light-diffusing structural irregularities (roughness) (7) on its interior and/or surface, and/or with or without a protective coating (8) on the surface of the casing (6); the laser emitting tip (diffuser) (5) comprises a housing (6) made of quartz glass or a light conducting polymer, the interior and/or the surface of the housing (6) having light diffusing structural irregularities (roughness) (7), and/or the surface of the housing (6) having or not having a polymer protective coating (8); furthermore, the tip (diffuser) (5) is cylindrical, 0.2-10cm long, preferably 0.5-3cm long; a diameter of 0.02-0.2cm, which spreads the laser light over the entire surface, in particular over a length and circumference of an angle of 360 °, the penetration of the laser light in the biological tissue from the tip (diffuser) surface reaching 2cm when the wavelength of the light λ is 670-; when the wavelength of light λ is 790-830nm, the penetration of the laser light from the tip (diffuser) surface in the biological tissue reaches 5 cm.
2. The laser therapy fiber optic probe according to claim 1, wherein the laser emitting tip (diffuser) (5) is between 2-5cm in length, the optical fiber (2) is made of polymer fiber, the light diffusion angle is 360 °, the flux efficiency is at least 80%, and the tip (diffuser) (5) is 0.05cm in diameter; the length of the probe from the connecting plug (4) to the end of the laser emitting tip (5) is 30 +/-15 cm; when the laser beam power is 400mW, when the light wavelength lambda is 670-; when the wavelength of light λ is 790-830nm, the penetration of the laser light from the tip (diffuser) surface in the biological tissue reaches 5 cm.
3. The fiber optic probe for laser therapy according to claim 1, characterized in that the laser emitting tip (diffuser) (5) has a length comprised between 0.5 and 3cm, the optical fiber (2) is made of quartz glass, the light diffusion angle is 360 °, the flux efficiency is at least 80%, and the tip (diffuser) (5) has a diameter of 0.1+0.02 cm; the length from the connection plug (4) to the end of the light emission tip (5) is 25+10 cm; when the laser beam power is 1600mW, when the light wavelength lambda is 670-; when the wavelength of light λ is 790-830nm, the penetration of the laser light from the tip (diffuser) surface in the biological tissue reaches 5 cm.
4. A laser therapy fiber optic probe according to any of claims 1-3, wherein the maximum power of the laser beam of the probe with polymer fiber (2) and polymer tip (diffuser) (5) is up to 500 mW; or the maximum power of the laser beam of the probe with quartz fiber (2) and quartz tip (diffuser) (5) can reach 2000 mW.
5. The laser therapy fiber optic probe of any one of claims 1-4, wherein the laser therapy fiber optic probe is sterile and suitable for use for 2 years from its date of manufacture.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LT2019036A LT6795B (en) | 2019-06-19 | 2019-06-19 | Laser therapy fiber optic probe |
| LT2019036 | 2019-06-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112107801A true CN112107801A (en) | 2020-12-22 |
Family
ID=73654417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010547001.3A Pending CN112107801A (en) | 2019-06-19 | 2020-06-16 | Optical fiber probe for laser therapy |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN112107801A (en) |
| DE (1) | DE102020207582A1 (en) |
| LT (1) | LT6795B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023213711A1 (en) * | 2022-05-04 | 2023-11-09 | Koninklijke Philips N.V. | Photo stimulation therapy of tissue and associated devices, systems, and methods |
| CN116755190B (en) * | 2023-06-21 | 2024-04-19 | 青岛镭视光电科技有限公司 | Side-transmitting optical fiber and laser medical device |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5269777A (en) | 1990-11-01 | 1993-12-14 | Pdt Systems, Inc. | Diffusion tip for optical fibers |
| LT4113B (en) | 1995-05-23 | 1997-02-25 | Rimantas Mykolas Kanapenas | Magnetic laser apparatus applicable to therapy |
| US6366719B1 (en) | 2000-08-17 | 2002-04-02 | Miravant Systems, Inc. | Photodynamic therapy light diffuser |
-
2019
- 2019-06-19 LT LT2019036A patent/LT6795B/en not_active IP Right Cessation
-
2020
- 2020-06-16 CN CN202010547001.3A patent/CN112107801A/en active Pending
- 2020-06-18 DE DE102020207582.4A patent/DE102020207582A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE102020207582A1 (en) | 2020-12-24 |
| LT6795B (en) | 2021-01-25 |
| LT2019036A (en) | 2020-12-28 |
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