CN112093083A - Production and packaging method of biological pharmaceutical capsule - Google Patents

Production and packaging method of biological pharmaceutical capsule Download PDF

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Publication number
CN112093083A
CN112093083A CN202010990468.5A CN202010990468A CN112093083A CN 112093083 A CN112093083 A CN 112093083A CN 202010990468 A CN202010990468 A CN 202010990468A CN 112093083 A CN112093083 A CN 112093083A
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CN
China
Prior art keywords
capsule
packaging
stuffing box
plate
shaking
Prior art date
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Granted
Application number
CN202010990468.5A
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Chinese (zh)
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CN112093083B (en
Inventor
黄继彬
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Huajing biomedical Co.,Ltd.
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黄继彬
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Priority to CN202010990468.5A priority Critical patent/CN112093083B/en
Publication of CN112093083A publication Critical patent/CN112093083A/en
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Publication of CN112093083B publication Critical patent/CN112093083B/en
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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B1/04Methods of, or means for, filling the material into the containers or receptacles
    • B65B1/08Methods of, or means for, filling the material into the containers or receptacles by vibratory feeders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074Filling capsules; Related operations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B43/00Forming, feeding, opening or setting-up containers or receptacles in association with packaging
    • B65B43/42Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation

Abstract

The invention relates to a production and packaging method of a biopharmaceutical capsule, which uses capsule packaging and blanking equipment, wherein the capsule packaging and blanking equipment comprises supporting legs, a stuffing box and a blanking control device, the stuffing box is arranged on the supporting legs, the lower end of the stuffing box is provided with a discharge hole, and the blanking control device is arranged in the stuffing box. The invention can solve the problems that the accuracy of capsule filling cannot be ensured in the process of filling capsules by using a capsule aluminum-plastic packaging plate in the production process of the traditional biological pharmaceutical capsules, the problem that the material grooves on the capsule aluminum-plastic packaging plate are easy to be filled and omitted, secondary filling operation is needed, the capsules with different specifications and sizes cannot be adaptively adjusted when being packaged and filled, corresponding capsule blanking equipment needs to be prepared, the production cost is increased and the like.

Description

Production and packaging method of biological pharmaceutical capsule
Technical Field
The invention relates to the technical field of medical equipment, in particular to a production and packaging method of a biological pharmaceutical capsule.
Background
The biological pharmacy is a medicine which is produced by a biological technology in medicine and is low in cost for preventing and treating human diseases, the medicine is prepared into capsules, the respiratory tract and the intestinal tract of a human body can be effectively protected, the medicine property of the medicine is also protected, the capsules need to be packaged after the preparation of the capsules, and the capsules are packaged by using a capsule aluminum-plastic packaging plate in a common form.
But at present, the bio-pharmaceutical capsules have the problem that the accuracy of filling the capsules cannot be guaranteed in the process of filling the capsules by using the capsule aluminum-plastic packaging plate in the production process, so that the problem that the material grooves on the capsule aluminum-plastic packaging plate are filled with materials and are missed easily caused, secondary filling operation is required, the capsules of different specifications and sizes cannot be adjusted in an adaptive manner when being packaged and filled, corresponding capsule blanking equipment needs to be prepared, and the production cost and the like are increased.
Therefore, the invention provides a production and packaging method of the biological pharmaceutical capsule.
Disclosure of Invention
In order to achieve the purpose, the invention adopts the following technical scheme to realize the purpose: a production and packaging method of a biopharmaceutical capsule uses a capsule packaging and blanking device, the capsule packaging and blanking device comprises a supporting leg, a stuffing box and a blanking control device, the stuffing box is mounted on the supporting leg, a discharge hole is formed in the lower end of the stuffing box, and the blanking control device is arranged in the stuffing box;
the blanking control device comprises a triangular guide frame, guide plates, two-way telescopic rods, transverse shaking plates, control branched chains, longitudinal shaking units, a first motor and a worm, wherein the guide plates are symmetrically arranged on the inner walls of the front end and the rear end of the stuffing box, the triangular guide frame is arranged on the inner wall of the stuffing box at equal intervals from left to right, the two-way telescopic rods are arranged on the lower end surface of the triangular guide frame, the transverse shaking plates are symmetrically arranged at the two ends of the two-way telescopic rods, the lower ends of the transverse shaking plates are in sliding fit with the inner wall of the stuffing box, the control branched chains are arranged on the inner wall of the stuffing box between the two transverse shaking plates, sliding holes are symmetrically arranged at the front side and the rear side of each transverse shaking plate, the longitudinal shaking units are arranged in the sliding holes, abutting rods are arranged on the transverse shaking plates and abut against the control branched, the rear end of the worm is connected with an output shaft of the first motor;
a moving groove is formed in the guide plate between the two triangular guide frames, and the moving grooves formed in the two adjacent guide plates are arranged in a vertically staggered manner;
the stuffing box is provided with a movable groove which is matched with the movable groove to move, an auxiliary rod is arranged between the movable grooves in a sliding mode and penetrates through the movable grooves in a sliding mode, the auxiliary rod is located between two adjacent triangular guide frames, a rotating shaft is arranged on the outer wall of the rear end of the stuffing box at equal intervals from left to right, the rotating shaft is installed on the stuffing box through a bearing, the auxiliary rod is connected with an auxiliary telescopic rod through a pin shaft, the auxiliary telescopic rod is connected with the rotating shaft, a chain wheel is arranged on the outer wall of the rotating shaft, the chain wheels are connected through a chain, the rotating shaft located on the left side of the stuffing box is connected with a second motor through a coupler, and the second;
the capsule production and packaging method comprises the following steps of packaging capsules by using capsule packaging and blanking equipment;
step one, preparation operation, namely enabling the upper end surface of the capsule aluminum-plastic packaging plate to be attached to the lower end surface of a stuffing box, and controlling the capsule aluminum-plastic packaging plate to move at a constant speed during packaging operation;
step two, performing packaging, namely putting the capsules to be packaged into a filling box, and shaking the capsules at the position of a discharge port through a blanking control device to enable the capsules to smoothly fall into a trough of a capsule aluminum-plastic packaging plate from the discharge port;
step three, plastic packaging, namely covering and sealing the upper end surface of the capsule aluminum-plastic packaging plate filled with the capsule by using medical tinfoil to finish capsule packaging;
and step four, detecting and collecting, namely detecting the sealing performance of the capsule aluminum-plastic packaging plate subjected to plastic packaging in the step three, placing the capsule aluminum-plastic packaging plate into a collecting container according to the composite standard requirement, and performing unified collection.
The control branch chain comprises a hollow pipe, a worm wheel, a cylinder, a push rod, a push plate, a first step block, a second step block, a sliding block and a control rod, the hollow pipe is arranged between the inner walls of the stuffing box through a bearing, the worm wheel is arranged on the outer wall of the rear end of the hollow pipe, the worm wheel is meshed with the worm, a sliding groove is uniformly formed in the hollow pipe along the circumferential direction of the hollow pipe, the sliding block is arranged in the hollow pipe in a sliding manner, the sliding block extends to the outer side of the sliding groove in a sliding manner, the first step block is sleeved on the sliding block, the first step block is abutted against the abutting rod, the push rod is connected to the sliding block in a penetrating manner, the front end of the push rod extends to the outer side of the hollow pipe, the cylinder is arranged on the outer wall of the front end of the stuffing box, the push, the control rod is arranged in the control hole in an interactive mode, a spring is arranged between the control rod and the inner wall of the hollow tube, one end of the control rod abuts against the transverse shaking plate, and the other end of the transverse shaking plate abuts against the second step block.
Preferably, evenly be provided with the circular arc lug on a ladder piece, a ladder piece with lean on the pole cooperation control horizontal shaking board to shake when rotating.
Preferably, the longitudinal shaking unit comprises a longitudinal shaking plate, telescopic spring rods, a longitudinal telescopic plate and a guide shaking rod, the longitudinal shaking plate is arranged on the inner wall of the stuffing box in a sliding mode, the telescopic spring rods are symmetrically arranged at two ends of the longitudinal shaking plate, the longitudinal telescopic plate is arranged on the telescopic spring rods, the longitudinal telescopic plate abuts against the transverse shaking plate, the guide shaking rods are symmetrically arranged on the side wall of the longitudinal shaking plate, and the guide shaking rods penetrate through the sliding holes in a sliding mode.
Preferably, the guide shaking bars are of a wave-shaped structure, and the two guide shaking bars are arranged on the longitudinal shaking plate in a splayed shape.
Advantageous effects
1. The invention can solve the problems that the accuracy of capsule filling cannot be ensured in the process of filling capsules by using the capsule aluminum-plastic packaging plate in the production process of the existing biopharmaceutical capsules, the filling omission of the material groove on the capsule aluminum-plastic packaging plate is easily caused, secondary filling operation is required, the capsules with different specifications and sizes cannot be adaptively adjusted when being packaged and filled, corresponding capsule blanking equipment needs to be prepared, the production cost is increased and the like.
2. When the capsule aluminum-plastic packaging device works, the capsule aluminum-plastic packaging plate is attached to the bottom of the filling box through the existing equipment, after the positions of the trough and the discharge hole on the capsule aluminum-plastic packaging plate are adjusted, capsule particles are put into the filling box, the capsule aluminum-plastic packaging plate is controlled to move at a constant speed, and the capsule particles are accurately filled into the trough on the capsule aluminum-plastic packaging plate through the blanking control device.
3. According to the capsule particle blanking device, the second motor is started in the process of controlling capsule particles to be blanked, the second motor controls the rotating shaft to rotate in a reciprocating mode at a specified angle through the cooperation between the chain wheel and the chain, the rotating shaft controls the two auxiliary rods to swing back and forth in a staggered mode through the auxiliary telescopic rods during rotation, the two auxiliary rods can adjust the angle of the capsule particles in a vertical state in the moving process, and the capsule particles are further guaranteed to smoothly fall into the material groove of the capsule aluminum-plastic packaging plate.
Drawings
The invention is further illustrated with reference to the following figures and examples.
FIG. 1 is a flow chart of a method of producing and packaging biopharmaceutical capsules in accordance with the present invention;
FIG. 2 is a plan view of the capsule packaging and blanking apparatus of the present invention;
3 FIG. 3 3 3 is 3 a 3 cross 3- 3 sectional 3 view 3 taken 3 along 3 line 3 A 3- 3 A 3 of 3 FIG. 3 2 3 in 3 accordance 3 with 3 the 3 present 3 invention 3; 3
FIG. 4 is an enlarged schematic view of the invention at B of FIG. 2;
FIG. 5 is a cross-sectional view taken along line C-C of FIG. 4 in accordance with the present invention;
FIG. 6 is a schematic structural diagram of the present invention between the lateral dithering plate and the longitudinal dithering unit;
FIG. 7 is a schematic view of the structure between the stuffing box, the auxiliary rod, the rotating shaft and the auxiliary telescopic rod of the present invention;
fig. 8 is a schematic structural diagram of the first step block of the present invention.
Detailed Description
The embodiments of the invention will be described in detail below with reference to the drawings, but the invention can be implemented in many different ways as defined and covered by the claims.
As shown in fig. 1 to 8, a method for producing and packaging a biopharmaceutical capsule uses a capsule packaging and blanking device, the capsule packaging and blanking device comprises a supporting leg 1, a stuffing box 2 and a blanking control device, the stuffing box 2 is mounted on the supporting leg 1, a discharge port is arranged at the lower end of the stuffing box 2, and the blanking control device is arranged in the stuffing box 2; attaching the capsule aluminum-plastic packaging plate to the bottom of a filling box 2 by the existing equipment, putting capsule particles into the filling box 2 after adjusting the positions of a trough and a discharge port on the capsule aluminum-plastic packaging plate, controlling the capsule aluminum-plastic packaging plate to move at a constant speed, and accurately filling the capsule particles into the trough on the capsule aluminum-plastic packaging plate by a blanking control device;
the blanking control device comprises a triangular guide frame 3, guide plates 4, a two-way telescopic rod 5, a transverse shaking plate 6, control branched chains 7, a longitudinal shaking unit 8, a first motor 9 and a worm 10, wherein the inner walls of the front end and the rear end of the stuffing box 2 are symmetrically provided with the guide plates 4, the triangular guide frame 3 is arranged on the inner wall of the stuffing box 2 at equal intervals from left to right, the two-way telescopic rod 5 is arranged on the lower end surface of the triangular guide frame 3, the two ends of the two-way telescopic rod 5 are symmetrically provided with the transverse shaking plate 6, the lower end of the transverse shaking plate 6 is in sliding fit with the inner wall of the stuffing box 2, the control branched chains 7 are arranged on the inner wall of the stuffing box 2 between the two transverse shaking plates 6, the front side and the rear side of the transverse shaking plate 6 are symmetrically provided with sliding holes, the sliding holes are provided with the longitudinal shaking unit 8, the transverse shaking plate, the outer wall of the stuffing box 2 is provided with a worm 10 through a bearing, and the rear end of the worm 10 is connected with an output shaft of a first motor 9; the bidirectional telescopic rod 5 plays a role in supporting and resetting the transverse shaking plates 6 in the operation process, the control branched chain 7 can control the distance between the transverse shaking plates 6, so that capsule particles with different specifications can be accurately controlled, the gap between the two transverse shaking plates 6 can be adaptively adjusted, the production and packaging requirements of the capsule particles with different specifications are met, the application range of the invention is widened,
the blanking controlling means during operation, it is rotatory to start first motor 9 control worm 10, worm 10 control branch chain 7 work, control branch chain 7 is at the in-process control horizontal shaking plate 6 of motion and vertical shaking unit 8 and carry out the shake of two directions around and, horizontal shaking plate 6 can adjust the position with the capsule granule with vertical shaking unit 8 at the in-process of motion, make can be smooth with the capsule granule fall into the silo on the capsule plastic-aluminum packing board from the discharge gate in, improve the precision in the capsule granule production packaging process.
The control branch chain 7 comprises a hollow pipe 71, a worm wheel 72, a cylinder 73, a push rod 74, a push plate 75, a first step block 76, a second step block 77, a sliding block 78 and a control rod 79, the hollow pipe 71 is installed between the inner walls of the stuffing box 2 through a bearing, the worm wheel 72 is installed on the outer wall of the rear end of the hollow pipe 71, the worm wheel 72 is meshed with the worm 10, sliding grooves are evenly formed in the hollow pipe 71 along the circumferential direction of the hollow pipe 71, the sliding block 78 is arranged in the hollow pipe 71 in a sliding mode, the sliding block 78 extends to the outer side of the sliding grooves in a sliding mode, the first step block 76 is sleeved with the first step block 76, the push rod 74 is abutted to the first step block 76, the front end of the push rod 74 is connected to the sliding block 78 in a penetrating mode, the outer wall of the front end of the stuffing box 2 is provided with the cylinder 73, the push rod 74 is provided with a second step block 77, the hollow pipe 71 is uniformly provided with control holes along the circumferential direction, the control holes are internally and interactively provided with control rods 79, a spring is arranged between the control rods 79 and the inner wall of the hollow pipe 71, one end of each control rod 79 abuts against the transverse shaking plate 6, and the other end of each transverse shaking plate 6 abuts against the second step block 77. Circular arc convex blocks are uniformly arranged on the first step block 76, and the first step block 76 is matched with the abutting rod to control the transverse shaking plate 6 to shake when rotating.
When the specifications of capsule particles for production and packaging are changed, the gap between the two transverse shaking plates 6 needs to be adjusted, at the moment, the air cylinder 73 is started to drive the pushing plate 75 to move, the pushing plate 75 drives the pushing rod 74 to slide in the hollow tube 71 in the moving process, the pushing rod 74 drives the second stepped block 77 to synchronously displace in the moving process, the transverse shaking plates 6 are driven to adjust through the change of the contact positions between the second stepped block 77 and the control rod 79, so that the gap between the two transverse shaking plates 6 is changed, the targeted capsule particles can smoothly slide downwards from the gap between the two transverse shaking plates 6, and the capsule particles can be accurately discharged from the position of a discharge port; and the push rod 74 controls the first step block 76 to carry on the position regulation synchronously through the slide block 78 in the course of moving, make the first step block 76 change with leaning against the position between the poles synchronously, thus adjust the shaking amplitude of the horizontal shaking plate 6, after the interval between two horizontal shaking plates 6 is adjusted, start the first electrical machinery 9, control the hollow tube 71 to rotate through the cooperation of worm gear 72 and worm 10, the second step block 77 controls the horizontal shaking plate 6 to shake in the horizontal direction while the hollow tube 71 rotates, thus the effective position to capsule granule is adjusted, guarantee the capsule granule falls into the compound packaging requirement of position in the trough of the capsule aluminum-plastic packaging plate;
the longitudinal shaking unit 8 comprises a longitudinal shaking plate 81, two telescopic spring rods 82, two longitudinal telescopic plates 83 and two guide shaking rods 84, the longitudinal shaking plate 81 is arranged on the inner wall of the stuffing box 2 in a sliding mode, the number of the longitudinal shaking plates 81 is two, the longitudinal shaking plates 81 are symmetrically arranged on two sides of a discharge port, the telescopic spring rods 82 are symmetrically arranged at two ends of the longitudinal shaking plate 81, the longitudinal telescopic plates 83 are arranged on the telescopic spring rods 82, the longitudinal telescopic plates 83 abut against the transverse shaking plate 6, the guide shaking rods 84 are symmetrically arranged on the side wall of the longitudinal shaking plate 81, and the guide shaking rods 84 slide through sliding holes.
The guide shaking bars 84 are of a wave-shaped structure, and the two guide shaking bars 84 are arranged on the longitudinal shaking plate 81 in a splayed shape.
When the gap between the two transverse shaking plates 6 is changed, pressure is applied to the longitudinal stretching plate 83, the stretching spring rod 82 plays a role in supporting and resetting the longitudinal stretching plate 83, and after the gap between the transverse shaking plates 6 is changed, the contact position between the sliding hole and the guide shaking plates 84 is changed synchronously, so that the gap between the two longitudinal shaking plates 81 can be changed through adjusting the two transverse shaking plates 6, and capsule particles with different specifications are accurately limited through the position change between the two transverse shaking plates 6 and the two longitudinal shaking plates 81; and the transverse shaking plate 6 can drive the two longitudinal shaking plates 81 to carry out synchronous shaking operation through the matching between the sliding hole and the guide shaking rod 84 when shaking.
In order to place the capsule particles in the stuffing box 2 to vertically fall during blanking, the following design is made:
a moving groove is formed in the guide plate 4 between the two triangular guide frames 3, and the moving grooves formed in the two adjacent guide plates 4 are arranged in a vertically staggered manner;
the stuffing box 2 is provided with a movable groove which is matched with the movable groove to move, an auxiliary rod 21 is arranged between the movable grooves in a sliding mode, the auxiliary rod 21 penetrates through the movable groove in a sliding mode, the auxiliary rod 21 is located between two adjacent triangular guide frames 3, a rotating shaft 22 is arranged on the outer wall of the rear end of the stuffing box 2 at equal intervals from left to right, the rotating shaft 22 is installed on the stuffing box 2 through a bearing, an auxiliary telescopic rod 23 is connected to the auxiliary rod 21 through a pin shaft, the auxiliary telescopic rod 23 is connected with the rotating shaft 22, a chain wheel is arranged on the outer wall of the rotating shaft 22, the chain wheels are connected through a chain, the rotating shaft 22 located on the left side of the stuffing box 2 is connected with a second motor 26 through a coupling, and;
carry out the in-process of blanking at control capsule granule and start second motor 26, second motor 26 carries out reciprocating rotation at appointed angle through the cooperation control axis of rotation 22 between sprocket and the chain, axis of rotation 22 carries out crisscross back and forth swing through two auxiliary rod 21 of auxiliary telescopic rod 23 control when rotating, and two auxiliary rod 21 can adjust the angle of the capsule granule of vertical state at the in-process of motion, further guarantee that the capsule granule is smooth fall into in the capsule plastic-aluminum packing plate silo.
The capsule production and packaging method comprises the following steps of packaging capsules by using capsule packaging and blanking equipment;
step one, preparation operation, namely enabling the upper end face of the capsule aluminum-plastic packaging plate to be attached to the lower end face of the stuffing box 2, and controlling the capsule aluminum-plastic packaging plate to move at a constant speed during packaging operation;
step two, performing packaging, namely putting the capsules to be packaged into a filling box 2, and shaking the capsules at the position of a discharge port through a blanking control device to enable the capsules to smoothly fall into a trough of a capsule aluminum-plastic packaging plate from the discharge port;
step three, plastic packaging, namely covering and sealing the upper end surface of the capsule aluminum-plastic packaging plate filled with the capsule by using medical tinfoil to finish capsule packaging;
and step four, detecting and collecting, namely detecting the sealing performance of the capsule aluminum-plastic packaging plate subjected to plastic packaging in the step three, placing the capsule aluminum-plastic packaging plate into a collecting container according to the composite standard requirement, and performing unified collection.
The production and packaging method for the biopharmaceutical capsules overcomes the problems that the accuracy of capsule filling cannot be guaranteed in the process of filling capsules by using a capsule aluminum-plastic packaging plate in the production process of the biopharmaceutical capsules at present, missing and missing of filling in a trough on the capsule aluminum-plastic packaging plate are easily caused, secondary filling operation is required, adaptive adjustment cannot be performed when the capsules with different specifications and sizes are packed and filled, corresponding capsule blanking equipment needs to be prepared, the production cost is increased, and the like.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (5)

1. A production and packaging method of a biopharmaceutical capsule uses a capsule packaging and blanking device, and the capsule packaging and blanking device comprises a supporting leg (1), a stuffing box (2) and a blanking control device, and is characterized in that the supporting leg (1) is provided with the stuffing box (2), the lower end of the stuffing box (2) is provided with a discharge hole, and the stuffing box (2) is internally provided with the blanking control device;
the blanking control device comprises a triangular guide frame (3), guide plates (4), two-way telescopic rods (5), transverse shaking plates (6), control branch chains (7), a longitudinal shaking unit (8), a first motor (9) and a worm (10), wherein the guide plates (4) are symmetrically arranged on the inner walls of the front end and the rear end of the stuffing box (2), the triangular guide frame (3) is arranged on the inner wall of the stuffing box (2) at equal intervals from left to right, the two-way telescopic rods (5) are arranged on the lower end face of the triangular guide frame (3), the transverse shaking plates (6) are symmetrically arranged at the two ends of the two-way telescopic rods (5), the lower ends of the transverse shaking plates (6) are in sliding fit with the inner wall of the stuffing box (2), the control branch chains (7) are arranged on the inner wall of the stuffing box (2) between the two transverse shaking plates (6), sliding holes are symmetrically formed in the front side and the rear side of the, the sliding hole is provided with a longitudinal shaking unit (8), the transverse shaking plate (6) is provided with a leaning rod, the leaning rod leans against the control branched chain (7), the outer wall of the stuffing box (2) is provided with a worm (10) through a bearing, and the rear end of the worm (10) is connected with an output shaft of a first motor (9);
a moving groove is formed in the guide plate (4) between the two triangular guide frames (3), and the moving grooves formed in the two adjacent guide plates (4) are arranged in a vertically staggered manner;
the stuffing box (2) is provided with a movable groove which is matched with the movable groove to move, an auxiliary rod (21) is arranged between the movable grooves in a sliding mode, the auxiliary rod (21) penetrates through the movable grooves in a sliding mode, the auxiliary rod (21) is located between two adjacent triangular guide frames (3), rotating shafts (22) are arranged on the outer wall of the rear end of the stuffing box (2) at equal intervals from left to right, the rotating shafts (22) are installed on the stuffing box (2) through bearings, the auxiliary rod (21) is connected with an auxiliary telescopic rod (23) through a pin shaft, the auxiliary telescopic rod (23) is connected with the rotating shafts (22), chain wheels are arranged on the outer wall of the rotating shafts (22), the chain wheels are connected through chains, the rotating shafts (22) located on the left side of the stuffing box (2) are connected with a second motor (26) through couplers, and the second motor (26) is fixed;
the capsule production and packaging method comprises the following steps of packaging capsules by using capsule packaging and blanking equipment;
step one, preparation operation, namely enabling the upper end surface of the capsule aluminum-plastic packaging plate to be attached to the lower end surface of the stuffing box (2), and controlling the capsule aluminum-plastic packaging plate to move at a constant speed during packaging operation;
step two, performing packaging, namely putting the capsules to be packaged into a filling box (2), and shaking the capsules positioned at a discharge port through a blanking control device to enable the capsules to smoothly fall into a trough of a capsule aluminum-plastic packaging plate from the discharge port;
step three, plastic packaging, namely covering and sealing the upper end surface of the capsule aluminum-plastic packaging plate filled with the capsule by using medical tinfoil to finish capsule packaging;
and step four, detecting and collecting, namely detecting the sealing performance of the capsule aluminum-plastic packaging plate subjected to plastic packaging in the step three, placing the capsule aluminum-plastic packaging plate into a collecting container according to the composite standard requirement, and performing unified collection.
2. The method for producing and packaging biopharmaceutical capsules according to claim 1, wherein said method comprises the steps of: the control branch chain (7) comprises a hollow pipe (71), a worm wheel (72), a cylinder (73), a push rod (74), a push plate (75), a first step block (76), a second step block (77), a sliding block (78) and a control rod (79), the hollow pipe (71) is installed between the inner walls of the stuffing box (2) through bearings, the worm wheel (72) is installed on the outer wall of the rear end of the hollow pipe (71), the worm wheel (72) is meshed with the worm (10), a sliding groove is evenly formed in the hollow pipe (71) along the circumferential direction of the hollow pipe, the sliding block (78) is arranged in the hollow pipe (71) in a sliding mode, the sliding block (78) extends to the outer side of the sliding groove in a sliding mode, the sliding block (78) is sleeved with the first step block (76), the first step block (76) is abutted to the abutting rod, the push rod (74) is connected to the sliding block (78) in a penetrating mode, install on the front end outer wall of gland box (2) cylinder (73), install slurcam (75) on cylinder (73), link to each other through the bearing between slurcam (75) and push rod (74), be provided with No. two ladder pieces (77) on push rod (74), evenly be provided with the control hole along its circumference on hollow tube (71), the interdynamic control pole (79) that is provided with in the control hole, be provided with the spring between the inner wall of control pole (79) and hollow tube (71), the one end of control pole (79) is supported and is leaned on horizontal shake board (6), the other end of horizontal shake board (6) is supported and is leaned on No. two ladder pieces (77).
3. The method for producing and packaging biopharmaceutical capsules according to claim 2, wherein said method comprises the steps of: an arc bump is uniformly arranged on the first step block (76), and the first step block (76) is matched with the leaning rod to control the transverse shaking plate (6) to shake when rotating.
4. The method for producing and packaging biopharmaceutical capsules according to claim 1, wherein said method comprises the steps of: vertical shake unit (8) including vertical shake board (81), telescopic spring pole (82), vertical expansion plate (83) and direction shake pole (84), vertical shake board (81) slide to set up on the inner wall of stuffing box (2), telescopic spring pole (82) are installed to the both ends symmetry of vertical shake board (81), install vertical expansion plate (83) on telescopic spring pole (82), vertical expansion plate (83) support and lean on horizontal shake board (6), the symmetry is provided with direction shake pole (84) on the lateral wall of vertical shake board (81).
5. The method for producing and packaging biopharmaceutical capsules according to claim 4, wherein said method comprises the steps of: the guide shaking rods (84) are of a wave-shaped structure, and the two guide shaking rods (84) are arranged on the longitudinal shaking plate (81) in a splayed shape.
CN202010990468.5A 2020-09-19 2020-09-19 Production and packaging method of biological pharmaceutical capsule Active CN112093083B (en)

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CN202010990468.5A CN112093083B (en) 2020-09-19 2020-09-19 Production and packaging method of biological pharmaceutical capsule

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CN202010990468.5A CN112093083B (en) 2020-09-19 2020-09-19 Production and packaging method of biological pharmaceutical capsule

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CN112093083A true CN112093083A (en) 2020-12-18
CN112093083B CN112093083B (en) 2021-10-26

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Citations (6)

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