CN112041025A - 用于进行头部照射的光治疗设备及光治疗仪及其治疗方法 - Google Patents
用于进行头部照射的光治疗设备及光治疗仪及其治疗方法 Download PDFInfo
- Publication number
- CN112041025A CN112041025A CN202080002238.1A CN202080002238A CN112041025A CN 112041025 A CN112041025 A CN 112041025A CN 202080002238 A CN202080002238 A CN 202080002238A CN 112041025 A CN112041025 A CN 112041025A
- Authority
- CN
- China
- Prior art keywords
- infrared light
- light
- pulse frequency
- infrared
- wavelength
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 165
- 238000011282 treatment Methods 0.000 title claims abstract description 128
- 238000001126 phototherapy Methods 0.000 title claims description 65
- 208000024827 Alzheimer disease Diseases 0.000 claims abstract description 79
- 238000005286 illumination Methods 0.000 claims abstract description 41
- 210000004556 brain Anatomy 0.000 claims abstract description 32
- 230000006378 damage Effects 0.000 claims abstract description 21
- 210000002569 neuron Anatomy 0.000 claims abstract description 19
- 230000003930 cognitive ability Effects 0.000 claims abstract description 18
- 210000000944 nerve tissue Anatomy 0.000 claims abstract description 16
- 238000011069 regeneration method Methods 0.000 claims abstract description 16
- 230000001737 promoting effect Effects 0.000 claims abstract description 9
- 230000015556 catabolic process Effects 0.000 claims abstract description 8
- 230000004898 mitochondrial function Effects 0.000 claims abstract description 8
- 230000017423 tissue regeneration Effects 0.000 claims abstract 12
- 229940079593 drug Drugs 0.000 claims description 35
- 239000003814 drug Substances 0.000 claims description 35
- 230000007131 anti Alzheimer effect Effects 0.000 claims description 28
- 238000002560 therapeutic procedure Methods 0.000 claims description 27
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims description 26
- 238000000554 physical therapy Methods 0.000 claims description 26
- 230000008021 deposition Effects 0.000 claims description 25
- 201000010099 disease Diseases 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 230000005855 radiation Effects 0.000 claims description 16
- 230000000638 stimulation Effects 0.000 claims description 14
- 239000000544 cholinesterase inhibitor Substances 0.000 claims description 13
- 229960003530 donepezil Drugs 0.000 claims description 13
- 229960004640 memantine Drugs 0.000 claims description 13
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims description 13
- 238000011491 transcranial magnetic stimulation Methods 0.000 claims description 13
- 229940122041 Cholinesterase inhibitor Drugs 0.000 claims description 12
- 229940099433 NMDA receptor antagonist Drugs 0.000 claims description 12
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 claims description 12
- 230000008439 repair process Effects 0.000 claims description 11
- 230000008929 regeneration Effects 0.000 claims description 10
- 230000017525 heat dissipation Effects 0.000 claims description 6
- 229940124810 Alzheimer's drug Drugs 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 241000220259 Raphanus Species 0.000 claims description 2
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
- 230000006933 amyloid-beta aggregation Effects 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 89
- 210000003128 head Anatomy 0.000 description 77
- 238000002474 experimental method Methods 0.000 description 30
- 238000012360 testing method Methods 0.000 description 30
- 241000699666 Mus <mouse, genus> Species 0.000 description 27
- 239000013641 positive control Substances 0.000 description 25
- 102000004169 proteins and genes Human genes 0.000 description 21
- 108090000623 proteins and genes Proteins 0.000 description 21
- 230000006870 function Effects 0.000 description 19
- 230000001276 controlling effect Effects 0.000 description 17
- 238000012549 training Methods 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 230000000694 effects Effects 0.000 description 16
- 238000010166 immunofluorescence Methods 0.000 description 16
- 230000009977 dual effect Effects 0.000 description 14
- 230000013016 learning Effects 0.000 description 13
- 230000001225 therapeutic effect Effects 0.000 description 12
- 241001465754 Metazoa Species 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 10
- 238000003491 array Methods 0.000 description 10
- 238000000354 decomposition reaction Methods 0.000 description 10
- 210000003470 mitochondria Anatomy 0.000 description 9
- 210000003710 cerebral cortex Anatomy 0.000 description 8
- 238000010586 diagram Methods 0.000 description 8
- 238000011830 transgenic mouse model Methods 0.000 description 8
- 230000007423 decrease Effects 0.000 description 7
- 210000001320 hippocampus Anatomy 0.000 description 7
- 238000003860 storage Methods 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- 230000015654 memory Effects 0.000 description 6
- 239000013642 negative control Substances 0.000 description 6
- 241000699660 Mus musculus Species 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000013105 post hoc analysis Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000007492 two-way ANOVA Methods 0.000 description 5
- 238000000116 DAPI staining Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 238000004043 dyeing Methods 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 238000002329 infrared spectrum Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000012188 paraffin wax Substances 0.000 description 4
- 238000010186 staining Methods 0.000 description 4
- 230000002411 adverse Effects 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 229960003135 donepezil hydrochloride Drugs 0.000 description 3
- XWAIAVWHZJNZQQ-UHFFFAOYSA-N donepezil hydrochloride Chemical compound [H+].[Cl-].O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 XWAIAVWHZJNZQQ-UHFFFAOYSA-N 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000007619 statistical method Methods 0.000 description 3
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 2
- 238000010175 APPswe/PSEN1dE9 Methods 0.000 description 2
- 206010012289 Dementia Diseases 0.000 description 2
- 206010039966 Senile dementia Diseases 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000003855 cell nucleus Anatomy 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000001149 cognitive effect Effects 0.000 description 2
- 230000003920 cognitive function Effects 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 238000013401 experimental design Methods 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 238000002653 magnetic therapy Methods 0.000 description 2
- 208000024714 major depressive disease Diseases 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000007087 memory ability Effects 0.000 description 2
- 206010027175 memory impairment Diseases 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000036651 mood Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 206010000117 Abnormal behaviour Diseases 0.000 description 1
- 206010054196 Affect lability Diseases 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 208000037259 Amyloid Plaque Diseases 0.000 description 1
- 206010003658 Atrial Fibrillation Diseases 0.000 description 1
- 206010003662 Atrial flutter Diseases 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000032274 Encephalopathy Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 229940127523 NMDA Receptor Antagonists Drugs 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 238000001604 Rao's score test Methods 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 208000003734 Supraventricular Tachycardia Diseases 0.000 description 1
- 201000004810 Vascular dementia Diseases 0.000 description 1
- 206010047571 Visual impairment Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000015114 central nervous system disease Diseases 0.000 description 1
- 230000006999 cognitive decline Effects 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 230000003937 effect on alzheimer disease Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000000556 factor analysis Methods 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 210000004326 gyrus cinguli Anatomy 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 230000000971 hippocampal effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000010185 immunofluorescence analysis Methods 0.000 description 1
- 238000003125 immunofluorescent labeling Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000008449 language Effects 0.000 description 1
- 208000011977 language disease Diseases 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000007334 memory performance Effects 0.000 description 1
- 230000006996 mental state Effects 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 230000016273 neuron death Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000002360 prefrontal effect Effects 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012502 risk assessment Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 230000006886 spatial memory Effects 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 102000013498 tau Proteins Human genes 0.000 description 1
- 108010026424 tau Proteins Proteins 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 206010047302 ventricular tachycardia Diseases 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000031836 visual learning Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0618—Psychological treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0622—Optical stimulation for exciting neural tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
- A61M2021/0027—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
- A61M2021/0055—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with electric or electro-magnetic fields
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
- A61M2021/0072—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus with application of electrical currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/27—General characteristics of the apparatus preventing use
- A61M2205/276—General characteristics of the apparatus preventing use preventing unwanted use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3546—Range
- A61M2205/3553—Range remote, e.g. between patient's home and doctor's office
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3546—Range
- A61M2205/3561—Range local, e.g. within room or hospital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
- A61M2205/3584—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using modem, internet or bluetooth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
- A61M2205/3592—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using telemetric means, e.g. radio or optical transmission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/502—User interfaces, e.g. screens or keyboards
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/587—Lighting arrangements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/08—Supports for equipment
- A61M2209/082—Mounting brackets, arm supports for equipment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/08—Supports for equipment
- A61M2209/088—Supports for equipment on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/002—Magnetotherapy in combination with another treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N2005/002—Cooling systems
- A61N2005/005—Cooling systems for cooling the radiator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0626—Monitoring, verifying, controlling systems and methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0626—Monitoring, verifying, controlling systems and methods
- A61N2005/0629—Sequential activation of light sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0642—Irradiating part of the body at a certain distance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0645—Applicators worn by the patient
- A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
- A61N2005/0652—Arrays of diodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/01—Devices for producing movement of radiation source during therapy
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F21/00—Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity
- G06F21/30—Authentication, i.e. establishing the identity or authorisation of security principals
- G06F21/31—User authentication
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Social Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Developmental Disabilities (AREA)
- Child & Adolescent Psychology (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
一种光治疗设备(100)、光治疗仪(500)，包括用于向头部发射近红外光的近红外照射模块(110)，以及用于控制所述近红外照射模块(110)的工作的与所述近红外照射模块(110)耦合的控制部件(120)。一种使用近红外光治疗的方法，包括向患者头部施用第一、任选的第二、任选的第三或更多近红外光。设备和方法用于治疗阿尔茨海默症、改善脑部线粒体的功能和ATP的水平、促进β‑淀粉样蛋白(Aβ)分解、减少Aβ的沉积、降低对神经细胞的损伤、提高神经组织的修复和再生能力、改善认知能力等。一种使用光治疗设备(110)或光治疗仪(500)的治疗方法，以及控制发射所需近红外光的计算机可读记录介质。
Description
PCT国内申请，说明书已公开。
Claims (1)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110932485.8A CN113457022A (zh) | 2019-06-17 | 2020-06-16 | 用于进行头部照射的光治疗设备及光治疗仪及其治疗方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019105222716 | 2019-06-17 | ||
| CN201910522271 | 2019-06-17 | ||
| PCT/CN2020/096249 WO2020173512A2 (zh) | 2019-06-17 | 2020-06-16 | 用于进行头部照射的光治疗设备及光治疗仪及其治疗方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110932485.8A Division CN113457022A (zh) | 2019-06-17 | 2020-06-16 | 用于进行头部照射的光治疗设备及光治疗仪及其治疗方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112041025A true CN112041025A (zh) | 2020-12-04 |
| CN112041025B CN112041025B (zh) | 2021-09-03 |
Family
ID=72240231
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080002238.1A Active CN112041025B (zh) | 2019-06-17 | 2020-06-16 | 用于进行头部照射的光治疗设备及光治疗仪及其治疗方法 |
| CN202110932485.8A Pending CN113457022A (zh) | 2019-06-17 | 2020-06-16 | 用于进行头部照射的光治疗设备及光治疗仪及其治疗方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110932485.8A Pending CN113457022A (zh) | 2019-06-17 | 2020-06-16 | 用于进行头部照射的光治疗设备及光治疗仪及其治疗方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220362576A1 (zh) |
| EP (1) | EP3984593A4 (zh) |
| CN (2) | CN112041025B (zh) |
| WO (1) | WO2020173512A2 (zh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3241978A1 (en) * | 2021-12-28 | 2023-07-06 | Daifa Wang | Phototherapy device and phototherapy apparatus for cerebral functional related disease |
| TWI837628B (zh) * | 2022-03-30 | 2024-04-01 | 明志科技大學 | 發光照明頭戴裝置 |
| WO2024022381A1 (en) * | 2022-07-26 | 2024-02-01 | Danyang Huichuang Medical Equipment Co., Ltd. | Phototherapy apparatus for treating alzheimer's disease |
| CN117563142B (zh) * | 2024-01-15 | 2024-04-02 | 南方医科大学南方医院 | 一种头戴式精准定位的经颅磁刺激仪 |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6267721B1 (en) * | 1999-06-18 | 2001-07-31 | William F. Welles | Method and apparatus for stress relief system |
| US7534255B1 (en) * | 2003-01-24 | 2009-05-19 | Photothera, Inc | Low level light therapy for enhancement of neurologic function |
| US8941509B2 (en) * | 2011-08-01 | 2015-01-27 | Greenwave Systems Pte. Ltd. | Multiple and interchangeable meter reading probes |
| CN204182026U (zh) * | 2014-08-20 | 2015-03-04 | 熊志伟 | 一种治疗口腔咽喉病症的近红外光照射理疗仪 |
| CN105126256A (zh) * | 2015-09-24 | 2015-12-09 | 黄勇 | 一种用于治疗阿尔兹海默病的近红外光照治疗装置 |
| CN107072821A (zh) * | 2014-09-09 | 2017-08-18 | 卢米希拉公司 | 用于损伤或患病组织的非侵入性治疗的多波长光疗装置、系统和方法 |
| CN107185113A (zh) * | 2017-06-14 | 2017-09-22 | 黄勇 | 治疗装置及包括该治疗装置的治疗设备 |
| CN107626038A (zh) * | 2017-10-27 | 2018-01-26 | 成都三乙医疗科技有限公司 | 一种头部治疗仪 |
| CN107648209A (zh) * | 2017-09-20 | 2018-02-02 | 东北师范大学 | 一种化合物在改善认知记忆能力和减少老年斑方面的应用 |
| CN108324711A (zh) * | 2018-05-03 | 2018-07-27 | 东北师范大学 | 一种化合物在拮抗蛋白聚积治疗老年痴呆方面的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040122492A1 (en) * | 1999-07-07 | 2004-06-24 | Yoram Harth | Phototherapeutic treatment of skin conditions |
| US7303578B2 (en) * | 2001-11-01 | 2007-12-04 | Photothera, Inc. | Device and method for providing phototherapy to the brain |
| US10695579B2 (en) * | 2006-01-30 | 2020-06-30 | Pthera LLC | Apparatus and method for indicating treatment site locations for phototherapy to the brain |
| WO2008131343A1 (en) * | 2007-04-19 | 2008-10-30 | Mergenet Medical, Inc. | Temporal control in phototherapy |
| US9320914B2 (en) * | 2008-03-03 | 2016-04-26 | DePuy Synthes Products, Inc. | Endoscopic delivery of red/NIR light to the subventricular zone |
| US8192473B2 (en) * | 2008-09-19 | 2012-06-05 | Apira Science, Inc. | Phototherapy apparatus for hair, scalp and skin treatment |
| US20120046716A1 (en) * | 2009-04-13 | 2012-02-23 | Gordon Rex Paterson Dougal | Phototherapy Apparatus |
| US20180256917A9 (en) * | 2009-06-19 | 2018-09-13 | Teng Lew Lim | Self-administrable method, system and apparatus for non-invasive neurostimulation therapy of the brain |
| US9833633B2 (en) * | 2009-11-25 | 2017-12-05 | Theradome, Inc. | Laser phototherapy device for illumination of the scalp to promote hair growth |
| CN101869740B (zh) * | 2010-06-23 | 2012-02-01 | 上海理工大学 | 治疗脑中枢神经系统疾病的头罩装置 |
| US20160067087A1 (en) * | 2014-09-09 | 2016-03-10 | LumiThera, Inc. | Wearable devices and methods for multi-wavelength photobiomodulation for ocular treatments |
| EP3271011B1 (en) * | 2015-03-20 | 2020-01-15 | Lim, Teng Lew | Systemfor non-invasive neurostimulation therapy of the brain |
| JP2019524179A (ja) * | 2016-08-09 | 2019-09-05 | オーハイ レチナル テクノロジー，エルエルシー | 生体組織または生体液のための保護療法を提供するためのプロセス |
| CN107019849A (zh) * | 2017-03-27 | 2017-08-08 | 关夫 | 利用光刺激视觉神经治疗阿尔茨海默病的便携式治疗仪 |
| EP3694464A4 (en) * | 2017-10-10 | 2021-07-07 | Massachusetts Institute of Technology | SYSTEMS AND PROCEDURES FOR PREVENTION, RELIEF AND / OR TREATMENT OF DEMENTIA |
-
2020
- 2020-06-16 WO PCT/CN2020/096249 patent/WO2020173512A2/zh unknown
- 2020-06-16 CN CN202080002238.1A patent/CN112041025B/zh active Active
- 2020-06-16 CN CN202110932485.8A patent/CN113457022A/zh active Pending
- 2020-06-16 EP EP20762632.6A patent/EP3984593A4/en active Pending
- 2020-06-16 US US17/620,403 patent/US20220362576A1/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6267721B1 (en) * | 1999-06-18 | 2001-07-31 | William F. Welles | Method and apparatus for stress relief system |
| US7534255B1 (en) * | 2003-01-24 | 2009-05-19 | Photothera, Inc | Low level light therapy for enhancement of neurologic function |
| US8941509B2 (en) * | 2011-08-01 | 2015-01-27 | Greenwave Systems Pte. Ltd. | Multiple and interchangeable meter reading probes |
| CN204182026U (zh) * | 2014-08-20 | 2015-03-04 | 熊志伟 | 一种治疗口腔咽喉病症的近红外光照射理疗仪 |
| CN107072821A (zh) * | 2014-09-09 | 2017-08-18 | 卢米希拉公司 | 用于损伤或患病组织的非侵入性治疗的多波长光疗装置、系统和方法 |
| CN105126256A (zh) * | 2015-09-24 | 2015-12-09 | 黄勇 | 一种用于治疗阿尔兹海默病的近红外光照治疗装置 |
| CN107185113A (zh) * | 2017-06-14 | 2017-09-22 | 黄勇 | 治疗装置及包括该治疗装置的治疗设备 |
| CN107648209A (zh) * | 2017-09-20 | 2018-02-02 | 东北师范大学 | 一种化合物在改善认知记忆能力和减少老年斑方面的应用 |
| CN107626038A (zh) * | 2017-10-27 | 2018-01-26 | 成都三乙医疗科技有限公司 | 一种头部治疗仪 |
| CN108324711A (zh) * | 2018-05-03 | 2018-07-27 | 东北师范大学 | 一种化合物在拮抗蛋白聚积治疗老年痴呆方面的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3984593A2 (en) | 2022-04-20 |
| EP3984593A4 (en) | 2023-06-28 |
| WO2020173512A2 (zh) | 2020-09-03 |
| CN113457022A (zh) | 2021-10-01 |
| WO2020173512A3 (zh) | 2020-11-05 |
| CN112041025B (zh) | 2021-09-03 |
| US20220362576A1 (en) | 2022-11-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112041025B (zh) | 用于进行头部照射的光治疗设备及光治疗仪及其治疗方法 | |
| CN111032151B (zh) | 用于利用光生物调节的自动个人化脑部调节的系统及方法 | |
| Chan et al. | Photobiomodulation improves the frontal cognitive function of older adults | |
| Jelic et al. | Apolipoprotein E ε4 allele decreases functional connectivity in Alzheimer’s disease as measured by EEG coherence | |
| Engel | Evolution of concepts in epilepsy surgery | |
| Quirk et al. | Near-infrared photobiomodulation in an animal model of traumatic brain injury: improvements at the behavioral and biochemical levels | |
| JP2022075862A (ja) | 光刺激による脳波及び細胞活性制御装置及び方法、並びに脳機能を改善、予防又は増大する装置 | |
| Woodruff-Pak et al. | Training to criterion in eyeblink classical conditioning in Alzheimer's disease, Down's syndrome with Alzheimer's disease, and healthy elderly. | |
| Rice et al. | Abnormal EEG slow activity in left temporal areas in senile dementia of the Alzheimer type | |
| Lopes et al. | Nat (UR) e: Quantifying the relaxation potential of ultra-reality multisensory nature walk experiences | |
| Bartlett et al. | Correlations between glucose metabolic rates in brain regions of healthy male adults at rest and during language stimulation | |
| Han et al. | Near infra-red light treatment of Alzheimer’s disease | |
| Han et al. | The effects of treatment room lighting color on time perception and emotion | |
| Fernandes et al. | Devices used for photobiomodulation of the brain—a comprehensive and systematic review | |
| Bernstein et al. | Differing patterns of electrodermal and finger pulse responsivity in schizophrenia and depression | |
| JP4411435B2 (ja) | 光刺激網膜検診方法及び光刺激網膜検診装置 | |
| Romagnoli et al. | Chromatic pupillometry for evaluating melanopsin retinal ganglion cell function in Alzheimer’s disease and other neurodegenerative disorders: a review | |
| Fénelon | Hallucinations associated with neurological disorders and sensory loss | |
| Sun et al. | Cortical activation patterns of different masking noises and correlation with their masking efficacy, determined by functional near-infrared spectroscopy | |
| Shue et al. | The effects of Mozart's music on the performance of glaucoma patients on automated perimetry | |
| Lebedeva et al. | Features of the operation of the mirror neuron system in patients with affective disorders | |
| Zhavoronkova et al. | Reduced electroencephalographic coherence asymmetry in the Chernobyl accident survivors | |
| WO2024176899A1 (ja) | 制御性ｔ細胞を誘導するための紫外線照射装置及び制御性ｔ細胞の製造方法 | |
| Salobrar-Garcia et al. | OPEN ACCESS EDITED BY | |
| Shalaby et al. | Photobiomodulation Therapy for a Novel Olfactory Dysfunction Ischemic Stroke Model |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40038948 Country of ref document: HK |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP02 | Change in the address of a patent holder |
Address after: 310051 room 2601-6, building 3, Haiwei business center, Xixing street, Binjiang District, Hangzhou City, Zhejiang Province Patentee after: Zhejiang lai'en Hass Medical Technology Co.,Ltd. Address before: 314400 room 610, 6 / F, Kechuang building, 128 Shuanglian Road, Haining Economic Development Zone, Haining City, Zhejiang Province Patentee before: Zhejiang lai'en Hass Medical Technology Co.,Ltd. |
|
| CP02 | Change in the address of a patent holder |