CN111991515A - Traditional Chinese medicine composition for treating yin deficiency wind-driving syndrome type apoplexy and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating yin deficiency wind-driving syndrome type apoplexy and preparation method thereof Download PDFInfo
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
The invention discloses a traditional Chinese medicine composition for treating yin deficiency wind-cold syndrome type apoplexy and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15-30 parts of gastrodia elata, 15-30 parts of uncaria, 10-12 parts of tortoise shell, 10-20 parts of radix scrophulariae, 3-4 parts of buffalo horn powder, 10-20 parts of angelica sinensis, 10-20 parts of ligusticum wallichii, 10-15 parts of lumbricus, 10-15 parts of safflower carthamus, 10-20 parts of chrysanthemum, 10-20 parts of rhizoma acori graminei and 5-10 parts of panax japonicus. The traditional Chinese medicine composition disclosed by the invention can obviously inhibit platelet aggregation, and has the effects of tranquilizing, easing pain, regulating blood pressure, improving cerebral circulation, enhancing immunity, improving motion function and life quality of a patient and the like, so that the effect of treating yin deficiency wind-driven stroke type apoplexy is achieved, the effect is quick, the curative effect is obvious, the side effect is small, and almost no damage is caused to a human body.
Description
Technical Field
The invention relates to a traditional Chinese medicine preparation for treating apoplexy (yin deficiency wind syndrome) and a preparation method thereof, belonging to the technical field of traditional Chinese medicine preparations.
Background
Apoplexy, also called cerebral apoplexy, is a common disease and a plurality of causes of nervous system, and has the characteristics of high morbidity, high disability rate, high mortality and high recurrence rate, and has become the first cause of death and disability of adults in China. Global disease burden (GBD) data shows that stroke has become the leading cause of life-year loss in our country in 2016. According to statistics, the per-patient hospitalization cost of 2016 China cerebral hemorrhage patients is 17787.0 yuan, and the per-patient hospitalization cost of apoplexy patients is 9387.0 yuan. This undoubtedly adds a significant economic burden to the families of patients who have experienced high mental stress.
Traditional Chinese medicine has long recognized the source of the probative stroke, and the stroke is recorded in the period of the Nei Jing, which belongs to the categories of 'attack', 'parakuan', 'parawind', and the like in the traditional Chinese medicine. Later-generation TCM classifies strokes into "meridians and collaterals" and "viscera" according to the severity of the disease. Among them, yin deficiency and wind stirring belongs to one of the "meridian qi in the category of" wind stirring ". For example, in Yun from Jingyue quan Shu, it is indicated for spasm and stiffness caused by yin deficiency and blood deficiency in all generations due to malnutrition of the tendons and vessels, such as stroke, which is always yin deficiency syndrome. Traditional medicine treatment modalities for this disease include: oral administration of Chinese medicinal materials, acupuncture therapy, external treatment of Chinese medicinal materials, massage therapy, and moxibustion therapy.
Modern medicine refers to stroke as cerebrovascular disease, which refers to brain dysfunction caused by various angiogenetic brain diseases. At present, western medicine mainly adopts methods of expanding blood vessels, reducing blood viscosity, lowering lipid, nourishing nerves, enhancing blood supply of ischemic and anoxic brain tissues, promoting functional recovery of neurons living in 'penumbra' and the like for treatment, can not completely cure the diseases, has obvious side effects of medicines and has high treatment cost.
The modern medicine has not yet presented a specific medicine for treating spastic hemiplegia after cerebral apoplexy. The main treatment methods comprise functional training, drug antagonism, incentive relief, active movement, passive movement, massage, surgical operation and the like. Wherein, taking western medicine may have: lethargy, digestive tract reaction, abnormal liver and kidney functions and the like, and the long-term curative effect is unclear. Local intramuscular injection is expensive and requires a high level of skill. The rehabilitation therapy has better curative effect, but many patients have difficulty in insisting on treatment due to long treatment course and slow effect. As for surgical treatment, the cost is generally high and has certain risk.
Disclosure of Invention
The invention aims to provide the traditional Chinese medicine composition for treating yin deficiency wind-cold syndrome type apoplexy and the preparation method thereof, and the traditional Chinese medicine composition has the advantages of simplicity, convenience, effectiveness and low price, thereby overcoming the defects of the prior art.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows:
a traditional Chinese medicine composition for treating yin deficiency wind-cold syndrome type apoplexy comprises the following raw materials in parts by weight: 15-30 parts of gastrodia elata, 15-30 parts of uncaria, 10-12 parts of tortoise shell, 10-20 parts of radix scrophulariae, 3-4 parts of buffalo horn powder, 10-20 parts of angelica sinensis, 10-20 parts of ligusticum wallichii, 10-15 parts of lumbricus, 10-15 parts of safflower carthamus, 10-20 parts of chrysanthemum, 10-20 parts of rhizoma acori graminei and 5-10 parts of panax japonicus.
As a preferred scheme, the traditional Chinese medicine composition for treating yin deficiency wind-cold syndrome type apoplexy further comprises the following raw materials in parts by weight: 10-15 parts of rhizopus chinensis.
The preparation method of the traditional Chinese medicine composition for treating yin deficiency wind-cold syndrome type apoplexy comprises the following steps:
(1) weighing the raw materials according to the formula, and putting the raw materials into a container;
(2) adding 5-10 times of water, soaking for 30-60min, boiling for 1-3 hr, and collecting filtrate;
(3) repeating for 2-3 times, and mixing filtrates.
A traditional Chinese medicine preparation for treating yin deficiency wind-cold syndrome type apoplexy, which is an oral preparation prepared from the traditional Chinese medicine composition of claim 1 or 2 and pharmaceutically acceptable auxiliary materials.
Preferably, the Chinese medicinal preparation for treating yin deficiency wind-evil type apoplexy is a granule, a pill, a tablet or a capsule.
The invention has the beneficial effects that: compared with the prior art, the traditional Chinese medicine composition for treating the yin deficiency wind-stroke type stroke has certain advantages, is based on the holistic concept and the traditional Chinese medicine basic theory of treating both principal and secondary aspects of disease, and has obvious effects on the aspects of improving the cognitive function of patients, reducing the dosage of western medicines, relieving the side effects of the western medicines and the like through traditional Chinese medicine treatment by means of the record of ancient medical books and the generation mutual transmission. The traditional Chinese medicine composition disclosed by the invention can obviously inhibit platelet aggregation, and has the effects of tranquilizing, easing pain, regulating blood pressure, improving cerebral circulation, enhancing immunity, improving motor function and life quality of patients and the like, so that the effect of treating yin deficiency wind-cold type stroke is achieved. In the preparation method, the raw materials and the water are boiled according to a proper proportion and repeated at least twice, so that the effective components in the raw materials can be fully extracted, and the loss and waste of the active components in the raw materials are reduced. The traditional Chinese medicine composition can be added with auxiliary materials to prepare a traditional Chinese medicine preparation, is convenient to take and carry, has small side effect, quick response and obvious curative effect, and different oral dosage forms can meet the selection requirements of patients on the dosage forms of the medicine.
The formula of the traditional Chinese medicine composition disclosed by the invention adopts a scientific and exquisite formula according to the monarch, minister, assistant and guide theory of the traditional Chinese medicine, and all raw material components are combined together, so that the obvious synergistic enhancement effect can be exerted, and therefore, the traditional Chinese medicine composition has an obvious treatment effect on the yin deficiency wind-type stroke, and hardly has damage to a human body. Specifically, the combination principle of the raw materials used in the traditional Chinese medicine composition is as follows:
the principal drugs include rhizoma Gastrodiae, ramulus Uncariae cum uncis, carapax et Plastrum Testudinis, and radix scrophulariae. The gastrodia elata is mild in nature and sweet in taste; entering liver meridian; has effects in calming liver, stopping endogenous wind, and relieving spasm. "Zhen Zhu Sac" (Pearl bag) for vertigo and headache due to wind deficiency); "compendium of materia Medica": gastrodia elata is a miraculous drug for treating wind. Modern researches have shown that rhizoma Gastrodiae has effects of relieving pain, tranquilizing, relieving convulsion, regulating blood pressure, improving eyesight, and improving intelligence. Ramulus Uncariae cum uncis enters liver meridian, and has effects of calming endogenous wind, relieving spasm, clearing heat, and lowering fire. In addition to the effects of reducing blood pressure and tranquilizing, the rhynchophylline contained in the medicine can inhibit the generation of malondialdehyde by platelets and inhibit the release of platelet factor IV, thereby playing the roles of inhibiting platelet aggregation and resisting thrombosis. Tortoise shell has effects of strengthening body, tranquilizing, nourishing kidney, suppressing yang, invigorating kidney, strengthening bone, nourishing blood, and improving cell immunity. Xuan Shen is sweet, bitter and salty in flavor, and enters lung, stomach and kidney meridians. Has the effects of nourishing yin, clearing heat, tonifying kidney and nourishing blood. In the application, tortoise shell and figwort are compatible, and can tonify kidney yin to inhibit liver yang and nourish water and culvert wood. And can clear away lung-heat, open the pure cloud of tin: descending of qi in the lung can treat liver wood. The combination of the two medicines of the tall gastrodia tuber and the gambir plant can coordinate to calm the liver and subdue yang, perform both attack and defense, nourish yin and stop wind.
The ministerial drugs comprise cornu Bubali powder, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, and rhizoma Acori Graminei. The buffalo horn powder is bitter in taste and cold in nature, enters heart and liver channels, and has the effects of clearing heat, cooling blood, detoxifying and arresting convulsion; yin deficiency produces internal heat, and angelica has the functions of enriching blood, promoting blood circulation, relaxing bowel and enhancing immunity. Chuan Xiong can activate blood and move qi, dispel wind and alleviate pain. According to the invention, the buffalo horn powder is matched with the angelica and the ligusticum wallichii, so that the buffalo horn powder is delicious but not greasy, tonifying but not gloomy, and the rhizoma acori graminei is pungent in taste and slightly warm; has effects in inducing resuscitation, eliminating dampness, regulating stomach function, tranquilizing mind, and improving intelligence. In conclusion, the invention takes the buffalo horn powder, the angelica, the ligusticum wallichii and the rhizoma acori graminei as ministers, regulates the liver, the heart and the spleen, nourishes blood, cools blood, clears heart and benefits intelligence, and is a great innovation point of the formula.
The adjuvant and guiding drugs comprise Lumbricus, Carthami flos, and flos Chrysanthemi. The earthworm is an insect drug, has the effects of clearing heat and calming wind, clearing and activating the channels and collaterals, and promoting blood circulation and removing blood stasis, is good at treating meridian blockage and unsmooth blood vessels, and is an important drug for treating cardiovascular and cerebrovascular diseases. Safflower, being warm in nature, promotes blood circulation, clears meridians, removes blood stasis and relieves pain. Chrysanthemum, slightly cold in nature, can disperse wind-heat and calm liver yang. In the application, the earthworm is matched with the safflower and the chrysanthemum, the activity and the static phase are proper, the cold and the heat are compatible, the effects of calming wind and clearing heat, dredging collaterals and activating blood are achieved together, and the liver wind is eliminated automatically when the blood flows. Panax japonicus is sweet in flavor and slightly warm in nature. Has the functions of nourishing and strengthening, eliminating blood stasis and relieving pain, stopping bleeding and eliminating phlegm. The root of bamboo is cold in nature, bitter in taste and slightly sweet. Has the effects of nourishing yin, clearing away lung-heat, promoting blood circulation and removing blood stasis. The rhizoma Panacis Japonici and rhizoma Panacis Japonici can be added on the basis of the above raw materials to harmonize the effects of the above drugs and enhance the drug effect.
In the present invention, the angelica can be the angelica, that is, only the middle part of the angelica is taken. Angelica is mainly used for enriching and nourishing blood, and whole angelica has the efficacy of enriching and activating blood. The Chinese medicinal composition is prepared by using the angelica as a medicament, and is easy to realize the synergistic interaction with other raw materials, so that the prepared Chinese medicinal composition has obvious medicinal effect. The carapax et Plastrum Testudinis may be vinegar carapax et Plastrum Testudinis. The vinegar tortoise shell is sweet in taste and slightly cold in nature; it enters liver, kidney and heart meridians; has effects in nourishing yin, suppressing yang, invigorating kidney, strengthening bone, consolidating channels, stopping bleeding, nourishing blood, and tonifying heart. The vinegar tortoise shells are adopted as ministerial drugs, and are easy to be cooperated with other raw materials for synergism, so that the prepared traditional Chinese medicine composition has obvious drug effect.
In conclusion, the selected traditional Chinese medicine raw materials and the dosage thereof have little damage to the human body, and the medicines have the effects of nourishing yin and calming wind, clearing heat and cooling blood, and dredging collaterals and promoting blood circulation together, so that yin blood is nourished, and the meridians are dredged to extinguish endogenous wind and restore brain collaterals. Therefore, the traditional Chinese medicine composition can obviously inhibit platelet aggregation, and has the effects of tranquilizing, easing pain, regulating blood pressure, improving cerebral circulation, enhancing immunity, improving motor function and life quality of patients and the like, so that the effect of treating yin deficiency wind-type stroke is achieved.
Detailed Description
The present invention will be further described with reference to the following examples. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
Example 1: traditional Chinese medicine granules for treating yin deficiency and wind-evil syndrome type apoplexy. Preparing raw materials: 20g of gastrodia elata, 20g of uncaria, 10g of tortoise shell, 10g of radix scrophulariae, 3g of buffalo horn powder, 20g of angelica, 12g of ligusticum wallichii, 10g of earthworm, 10g of safflower, 10g of chrysanthemum, 15g of rhizoma acori graminei and 8g of panax japonicus. Mixing raw materials and water according to a weight ratio of 1: 5 mixing, soaking for 30min, boiling for 1h, repeating for three times, mixing filtrates obtained each time, concentrating to obtain extract, and drying to obtain Chinese medicinal powder. Mixing 100g of Chinese medicinal powder, 200g of sucrose powder and 100g of dextrin uniformly, and making into oral granule.
Example 2: traditional Chinese medicine granules for treating yin deficiency and wind-evil syndrome type apoplexy. Preparing raw materials: 15g of gastrodia elata, 15g of uncaria, 10g of tortoise shell, 10g of radix scrophulariae, 3g of buffalo horn powder, 10g of angelica, 10g of ligusticum wallichii, 10g of earthworm, 10g of safflower, 10g of chrysanthemum, 10g of rhizoma acori graminei and g of panax japonicus. Mixing raw materials and water according to a weight ratio of 1: 10 mixing, soaking for 45min, boiling for 2h, repeating twice, mixing filtrates, concentrating to obtain extract, and drying to obtain Chinese medicinal powder. Mixing 100g of Chinese medicinal powder, 200g of sucrose powder and 100g of dextrin uniformly, and making into oral granule.
Example 3: traditional Chinese medicine granules for treating yin deficiency and wind-evil syndrome type apoplexy. Preparing raw materials: 30g of gastrodia elata, 30g of uncaria, 12g of tortoise shell, 20g of radix scrophulariae, 4g of buffalo horn powder, 20g of angelica, 20g of ligusticum wallichii, 15g of earthworm, 15g of safflower, 20g of chrysanthemum, 20g of rhizoma acori graminei and 10g of panax japonicus. Mixing raw materials and water according to a weight ratio of 1: 15 mixing, soaking for 60min, boiling for 3h, repeating twice, mixing filtrates obtained each time, concentrating to obtain extract, and drying to obtain Chinese medicinal powder. Mixing 100g of Chinese medicinal powder, 200g of sucrose powder and 100g of dextrin uniformly, and making into oral granule.
The effect of the drug particles in the examples of the present application was tested by the following tests.
Firstly, the effect of the traditional Chinese medicine granules on treating the yin deficiency wind-stroke type stroke is clinically verified.
60 patients with stroke of yin-deficiency and wind-movement type were selected, aged 60-80 years, and 30 each of male and female. 20 of the patients are orally treated by the traditional Chinese medicine granules in the embodiment 1, the rest 20 of the patients are orally treated by the traditional Chinese medicine granules in the embodiment 2, the rest 20 of the patients are orally treated by the traditional Chinese medicine granules in the embodiment 3, the traditional Chinese medicine granules are taken three times a day, and the traditional Chinese medicine granules are taken one hour after breakfast, lunch and supper, 10g of the traditional Chinese medicine granules are taken each time, and 1 month is a treatment course, which is 3 treatment courses.
Clinical verification shows that the total effective rate of the traditional Chinese medicine granules for treating the yin deficiency wind-stroke type stroke is 90.8%. Typical clinical cases are as follows:
case one: male, age 62, with weakness in the patient's left limb for 1 month; when the patient comes to a doctor, the left limb of the patient is weak, the speech is difficult, and dizziness, tinnitus, poor spirit, red tongue, little coating and wiry and thready pulse are caused; the stroke is diagnosed outside the hospital when the previous patient has the disease.
And (3) diagnosis: apoplexy-involving the meridians (wind-attacking due to yin deficiency), the Chinese medicinal granule of example 1 is orally administered.
After 1 month, the patient relieves dizziness symptoms earlier, and after taking the medicine for 2 months, the muscle strength of the left limb of the patient is increased earlier, the dizziness symptoms basically disappear, and tinnitus is obviously improved.
Case two: male, age 73, with weakness in the patient's right limb for 3 months; the patient has weakness, hemianesthesia, incapability of walking by oneself, lassitude, deep red tongue without coating and wiry and thready pulse on the right side when the patient comes to a clinic; stroke was diagnosed 3 months ago.
And (3) diagnosis: apoplexy-involving the meridians (wind-attacking due to yin deficiency), the Chinese medicinal granule of example 1 is orally administered.
After 1 month, the patient can walk with the help of the family and then wear the clothes for 2 months, and the right hand of the patient can hold the article and can walk by himself.
Case three: for a female, the age of 75 years old, the patient has repeated dizziness and headache for 2 months, and the patient has dizziness and headache when coming for a diagnosis, soreness and weakness of waist and knees, tinnitus, hypomnesis, poor spirit, poor sleep, red tongue with little coating and wiry and thready pulse; the left temporal lobe infarction was diagnosed before the half-month.
And (3) diagnosis: apoplexy-involving the meridians and collaterals (wind-stirring due to yin deficiency), the Chinese medicinal granule of example 2 is orally administered.
After 1 month, the patient has no headache and dizziness, and after taking the medicine for 2 months, the soreness and weakness of the waist and the knees of the patient are obviously relieved.
Case four: female, age 68, the right limb of the patient is not active for 2 months, when coming for a diagnosis, the patient is unstable walking, accompanied by dizziness, facial distortion, lassitude, poor sleep, good stool and stool, crimson tongue, little coating, wiry and thready pulse; the disease was diagnosed as late circulating stroke 2 months ago.
And (3) diagnosis: apoplexy-involving the meridians and collaterals (wind-stirring due to yin deficiency), the Chinese medicinal granule of example 2 is orally administered.
After 1 month, the patient got better before walking, had dizziness occasionally, and the spirit got better, took 2 months again, and the patient had no dizziness, and walked slightly unstably.
Case five: female, age 65, patient ambulation adverse for 4 months; when the patient comes to a doctor, the patient is disadvantaged in walking, hot in palms and soles, dry mouth and throat, soreness and weakness of waist and knees, crimson tongue, little coating and wiry and thready pulse; stroke was diagnosed 1 year ago.
And (3) diagnosis: apoplexy-involving the meridians (wind-attacking due to yin deficiency), the Chinese medicinal granule of example 3 is orally administered.
After 1 month, the symptoms of mouth dryness and dry throat of the patient basically disappear, the soreness and weakness of waist and knees are relieved earlier, and the patient can walk earlier and improve the symptoms of the mouth dryness and dry throat of the patient without suffering from feverish palms and soles after taking the medicine for 2 months.
Six cases: female, 72 years old, with the patient having impaired left limb movement for 1 year; when the diagnosis comes, the patient has difficulty in moving the left and lower limbs, stiff tongue and slurred speech, occasional dizziness, poor spirit, less sleep and dreaminess, dark and red tongue, little coating, wiry, thready and rapid pulse, and the like. Stroke was diagnosed 1 year ago.
And (3) diagnosis: apoplexy-involving the meridians (wind-attacking due to yin deficiency), the Chinese medicinal granule of example 3 is orally administered.
After 1 month, the patient has improved sleep, improved mental performance and reduced dizziness symptoms, and after taking the medicine for 2 months, the muscle strength of the left lower limb of the patient is improved, the language is fluent before, and no dizziness exists.
The embodiments of the present invention are not limited to the above-described examples, and various changes made without departing from the spirit of the present invention are within the scope of the present invention.
Claims (5)
1. A traditional Chinese medicine composition for treating yin deficiency wind-cold syndrome type apoplexy is characterized by comprising the following raw materials in parts by weight: 15-30 parts of gastrodia elata, 15-30 parts of uncaria, 10-12 parts of tortoise shell, 10-20 parts of radix scrophulariae, 3-4 parts of buffalo horn powder, 10-20 parts of angelica sinensis, 10-20 parts of ligusticum wallichii, 10-15 parts of lumbricus, 10-15 parts of safflower carthamus, 10-20 parts of chrysanthemum, 10-20 parts of rhizoma acori graminei and 5-10 parts of panax japonicus.
2. The traditional Chinese medicine composition for treating yin deficiency wind-cold syndrome type apoplexy according to claim 1, wherein the raw materials further comprise, by weight: 10-15 parts of rhizopus chinensis.
3. The method for preparing a Chinese medicinal composition according to claim 1 or 2, comprising the steps of:
(1) weighing the raw materials according to the formula, and putting the raw materials into a container;
(2) adding 5-10 times of water, soaking for 30-60min, boiling for 1-3 hr, and collecting filtrate;
(3) repeating for 2-3 times, and mixing filtrates.
4. A traditional Chinese medicine preparation for treating yin deficiency and wind syndrome type apoplexy is characterized in that: the traditional Chinese medicine composition of claim 1 or 2 and pharmaceutically acceptable auxiliary materials are prepared into an oral preparation.
5. The traditional Chinese medicine preparation for treating yin deficiency wind syndrome type apoplexy according to claim 4, wherein: the oral preparation is granules, pills, tablets or capsules.
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| CN115969938A (en) * | 2022-10-11 | 2023-04-18 | 华中农业大学 | Preparation method of traditional Chinese medicine prescription for inhibiting up-regulation of IGF-1R transcription level caused by streptococcus suis infection |
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