CN111904996A - Bone spur repairing cream containing Hetian jade microelements - Google Patents

Bone spur repairing cream containing Hetian jade microelements Download PDF

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CN111904996A
CN111904996A CN202010701310.1A CN202010701310A CN111904996A CN 111904996 A CN111904996 A CN 111904996A CN 202010701310 A CN202010701310 A CN 202010701310A CN 111904996 A CN111904996 A CN 111904996A
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hetian jade
powder
jade
hetian
cream containing
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陈桂芳
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Guangdong Shanshi Trace Element Research Institute (general Partnership)
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Guangdong Shanshi Trace Element Research Institute (general Partnership)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
    • A61K36/126—Drynaria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/12—Magnesium silicate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

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Abstract

The invention discloses a Hetian jade microelement bone spur repairing cream which comprises the following components in percentage by mass: 4-20% of traditional Chinese medicine composition, 1-10% of ultramicro Hetian jade powder, 1-8% of methyl glucose sesquistearate, 1-8% of cetearyl alcohol, 2-6% of polydimethylsiloxane, 1-6% of caprylic/capric triglyceride, 1-6% of stearic acid, 1-4% of shea butter, 0.8-2.5% of glyceryl stearate, 0.1-0.5% of carbomer, 0.1-0.3% of triethanolamine, 0.1-0.3% of phenoxyethanol and the balance of water. The invention takes the traditional Chinese medicine composition and the ultramicro Hetian jade powder as main functional components, has the functions of dredging the muscles and tendons, promoting blood circulation to stop pain, dispelling cold and resolving masses and conditioning the muscles and bones, and can effectively repair bony spur.

Description

Bone spur repairing cream containing Hetian jade microelements
Technical Field
The invention relates to a repair cream, in particular to a spur repair cream containing Hetian jade microelements.
Background
Bone spur is the natural aging phenomenon that cartilage is worn and damaged by various reasons and the bone is repaired, hardened and proliferated. The spur belongs to the category of arthralgia syndrome in traditional Chinese medicine, and is also called bone bi-syndrome. The traditional Chinese medicine considers that the disease is related to the causes of trauma, strain, blood stasis blocking collaterals, affection of wind-cold-dampness pathogen, phlegm-dampness internal resistance, liver and kidney deficiency, hyperosteogeny and the like. The middle-aged and the elderly gradually decline in body function, deficiency of qi and blood, malnutrition of channels and collaterals, and malnutrition of tendons and bones. The generation of spur is preceded by the failure of healthy qi to store inside, and then caused by pathogenic wind, cold, dampness, and stasis in the meridians and collaterals, resulting in unsmooth circulation of qi and blood, obstruction of the meridians and collaterals causing pain, and intermingled pathogenic qi. However, the spur is not exclusive to the elderly, and due to the change of working form, many office workers must sit or stand for a long time, and if the posture is incorrect, the spine is easy to degenerate early in age and gently, so that the spur is induced.
At present, most western medicines are treated by operation, so that the medical cost is high and the pain is great, and the traditional Chinese medicine has a plurality of formulas for treating the bony spur, but has the defects of low curative effect, slow response, complex formula medicine and the like. The invention patent CN201310614188.4 discloses a medicament for treating bony spur, which is characterized by comprising the following components in parts by weight: euphorbia kansui: 5-10%, radix angelicae: 5-10%, notopterygium root: 9-18%, pubescent angelica root: 10-20%, Chuanyun: 10-20%, corydalis tuber: 6-12%, garden balsam stem: 6-12%, caulis Spatholobi: 10-20%, spina gleditsiae: 9-18%, fructus toosendan: 7-14%, radix sophorae tonkinensis: 10 to 30 percent. The raw materials of the invention are relatively common, so that the whole medicine has substantial price, does not need to be operated, does not influence normal work and life, and has no pain when in use. However, the components of the invention are relatively complicated and the curative effect is general.
Disclosure of Invention
Based on the above, the invention aims to provide the bone spur repairing cream containing Hetian jade microelements, which takes the traditional Chinese medicine composition and the ultramicro Hetian jade powder as main functional components, has the effects of dredging tendons and vessels, promoting blood circulation to arrest pain, dispelling cold and resolving masses, conditioning muscles and bones, and can effectively repair bone spurs.
The invention adopts the following technical scheme:
the bone spur repairing cream containing the Hetian jade microelements comprises the following components in percentage by mass: 4-20% of a traditional Chinese medicine composition and 1-10% of ultramicro Hetian jade powder; wherein the traditional Chinese medicine composition is prepared from drynaria rhizome, muskmelon seed, passionflower herb and lobster sauce ginger according to the proportion of (1-5): (1-5): (1-5): (1-5) mixing and extracting.
The preparation method of the ultramicro Hetian jade powder comprises the following steps:
(1) cleaning crushed Hetian jade, removing impurities, and drying at low temperature;
(2) adding the removed Hetian jade into a vibration mill to grind into superfine powder with the particle size less than 10 mu m;
(3) and (3) burning the obtained powder at high temperature of 600-800 ℃ for 10min to remove mercury and arsenic in the powder, and cooling to obtain the ultramicro Hetian jade powder.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) weighing rhizoma Drynariae, semen melo, herba Passiflorae Caeruleae, semen Sojae Preparatum and rhizoma Zingiberis recens at a certain proportion, mixing, pulverizing in a pulverizer, and sieving with 100-200 mesh sieve to obtain mixed medicinal powder;
(2) according to the material-liquid ratio of 1: 5-15 adding 65% -85% ethanol into the mixed powder in the step (1), heating to 70 ℃, extracting under reflux for 1-3 times, extracting for 1-3 hours each time, filtering, and combining the filtrates;
(3) and (4) evaporating and concentrating the filtrate obtained in the step (3) to remove ethanol.
The bone spur repairing cream containing the Hetian jade microelements also comprises the following components in percentage by mass:
1-8% of methyl glucose sesquistearate, 1-8% of cetearyl alcohol, 2-6% of polydimethylsiloxane, 1-6% of caprylic/capric triglyceride, 1-6% of stearic acid, 1-4% of shea butter, 0.8-2.5% of glycerol stearate, 0.1-0.5% of carbomer, 0.1-0.3% of triethanolamine, 0.1-0.3% of phenoxyethanol and the balance of water.
The main functional components in the formula of the invention are introduced as follows:
rhizoma drynariae: warm in nature and bitter in taste. It enters liver and kidney meridians. Has effects in promoting wound healing, relieving pain, invigorating kidney, and strengthening bone. Pharmacological experiments show that the naringin has obvious effect of promoting bone injury healing and is one of the effective components of the rhizoma drynariae. The product also has effects in promoting bone absorption of calcium, increasing blood calcium and blood phosphorus levels, and promoting fracture healing. The rhizoma drynariae has certain functions of improving the function of chondrocytes and delaying cell degeneration.
Melon seeds: cold in nature and sweet in taste. It enters lung meridian, stomach meridian and large intestine meridian. Has effects of clearing lung-heat, moistening intestine, removing blood stasis, expelling pus, healing wound and relieving pain. Can be used for treating cough due to lung heat, constipation, pulmonary abscess, intestinal abscess, traumatic injury, and fracture and injury of tendons and bones.
Passionflower herb: warm in nature and bitter in taste. There is no meridian tropism. Has effects of dispelling pathogenic wind, removing dampness, promoting blood circulation, and relieving pain. It can be used for treating common cold, headache, nasal obstruction, watery nasal discharge, rheumatic arthralgia, hernia pain, dysmenorrhea, neuralgia, insomnia, dysentery, and fracture.
Fermented soya bean and ginger: pungent and bitter with warm nature. It enters stomach meridian, spleen meridian and liver meridian. Has effects of dispelling pathogenic wind, removing dampness, warming spleen and stomach, dispelling cold, activating qi-flowing, and promoting blood circulation. Can be used for treating common cold, wind cold, edema, loempe, arthralgia due to wind-cold-dampness, puerperal abdominal pain, blood stasis, dysmenorrhea, and abdominal distention due to qi stagnation and cold.
Hetian jade: one of the four Chinese jade products, Hetian jade is recorded in ancient medical titles such as Shennong's herbal Jing and Ben Cao gang mu: hetian jade has effects of removing heat, moistening heart and lung, nourishing hair, nourishing five internal organs, calming soul, dredging blood vessels, improving eyesight and ear, and there are 106 methods for oral administration and topical application. Hetian jade contains more than 10 trace elements, such as gold, silver, silicon, iron, selenium, magnesium, manganese, etc., and has effects of promoting blood circulation, enhancing metabolism, eliminating skin toxin, resisting radiation, repairing damaged skin cell and enhancing cell activity.
Compared with the prior art, the invention has the following beneficial effects:
(1) the traditional Chinese medicine composition is prepared by reasonably matching rhizoma drynariae, muskmelon seeds, passionflower herb and black bean ginger and scientifically mixing and extracting the components, can generate a synergistic interaction effect among the components, has the effects of dredging tendons and vessels, activating blood circulation to stop pain, dispelling cold and resolving masses and conditioning tendons and bones, and can effectively repair bony spurs.
(2) The invention also adds the ultramicro Hetian jade powder, which can supplement trace elements, promote local blood circulation, enhance metabolism and further repair bony spur.
(3) The product of the invention has the characteristics of mildness, no stimulation and no toxic or side effect, and can effectively repair bony spur.
Detailed Description
The invention is further illustrated by the following examples.
All ingredient names appearing herein are inci (international Nomenclature Cosmetic ingredient), a name specified by international Nomenclature for Cosmetic materials.
Examples 1-5 of the present invention formulations of the spur-repairing cream containing nephrite trace elements are shown in table 1.
TABLE 1
Figure BDA0002591597240000051
Comparative example 1
The difference from example 1 is that the traditional Chinese medicine composition is not added, and other preparation methods and conditions are the same as example 1.
Comparative example 2
The difference from example 1 is that no ultra fine hetian jade powder was added and the other preparation methods and conditions were the same as example 1.
Comparative example 3
The difference from the example 1 is that the traditional Chinese medicine composition does not contain rhizoma drynariae and melon seeds, and other preparation methods and conditions are the same as the example 1.
Comparative example 4
The difference from the example 1 is that the traditional Chinese medicine composition does not contain passion flower and lobster sauce ginger, and other preparation methods and conditions are the same as the example 1.
Example 6
Irritation test
10 Kunming mice are selected, the weight of the mice is 18-22 g, and the mice can be used for male and female. The bone spur repairing cream containing the Hetian jade microelements prepared in the embodiments 1-5 of the invention is externally applied according to 35 times of the dosage of people, the weight of the bone spur repairing cream is respectively weighed before and after the bone spur repairing cream is applied, and the eating, the activity and the fur condition of the white mouse are observed. After 7 days of continuous observation, no abnormality was found.
Example 7
Efficacy verification
In order to show the treatment effect of the product on the bony spur, through clinical treatment observation of 150 patients, 80 cases of men and 70 cases of women are observed. The patients were randomly divided into 10 groups of 8 men and 7 women, and the products prepared in examples 1 to 5 and comparative examples 1 to 4 of the present invention and commercially available drugs for treating bony spur were used.
Diagnostic criteria: the patients are not cured for a long time. The patients were confirmed in several hospitals.
The observation method comprises the following steps: the clinical symptoms before and after treatment are compared and followed for more than half a year.
The administration method comprises the following steps: the medicine is taken in the morning and at the evening. Two weeks is a course of treatment. After the treatment course is over, the local changes before and after the treatment are compared, and the specific results are shown in Table 2.
And (3) judging the curative effect standard:
and (3) curing: clinical symptoms disappear and the disease does not recur in half a year,
the effect is shown: the clinical symptoms partially disappeared.
And (4) invalidation: clinical symptoms did not progress significantly.
TABLE 2
Figure BDA0002591597240000071
As can be seen from the data in Table 2, the number of the patients with bony spur cured by the example group is obviously higher than that of the comparative example group and the commercial product group, which shows that the product of the invention can well treat bony spur; the comparison of the data of the embodiment group and the comparative example group can show that the traditional Chinese medicine composition and the ultramicro Hetian jade powder in the formula are main functional components, and the rhizoma drynariae, the muskmelon seed, the passionflower herb and the fermented soya bean ginger in the traditional Chinese medicine composition have a synergistic effect.
The foregoing examples are illustrative of embodiments of the present invention only and are not intended to be limiting in any way; those skilled in the art can make various changes and modifications to the disclosed technology, which are equivalent to those of the embodiments of the present invention, and it is within the scope of the present invention to make various changes and modifications of the invention based on the technical spirit of the present invention.

Claims (5)

1. The bone spur repairing cream containing the Hetian jade microelements is characterized by comprising the following components in percentage by mass: 4-20% of a traditional Chinese medicine composition and 1-10% of ultramicro Hetian jade powder; wherein the traditional Chinese medicine composition is prepared from drynaria rhizome, muskmelon seed, passionflower herb and lobster sauce ginger according to the proportion of (1-5): (1-5): (1-5): (1-5) mixing and extracting.
2. The bone spur repairing cream containing nephrite jade trace elements as claimed in claim 1, wherein the preparation method of the ultramicro nephrite jade powder comprises the following steps:
(1) cleaning crushed Hetian jade, removing impurities, and drying at low temperature;
(2) adding the removed Hetian jade into a vibration mill to grind into superfine powder with the particle size less than 10 mu m;
(3) and (3) burning the obtained powder at high temperature of 600-800 ℃ for 10min to remove mercury and arsenic in the powder, and cooling to obtain the ultramicro Hetian jade powder.
3. The bone spur repairing cream containing Hetian jade microelements as claimed in claim 1, wherein the preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) weighing rhizoma Drynariae, semen melo, herba Passiflorae Caeruleae, semen Sojae Preparatum and rhizoma Zingiberis recens at a certain proportion, mixing, pulverizing in a pulverizer, and sieving with 100-200 mesh sieve to obtain mixed medicinal powder;
(2) according to the material-liquid ratio of 1: 5-15 adding ethanol into the mixed medicinal powder in the step (1), heating to 70 ℃, extracting under reflux for 1-3 times, extracting for 1-3 hours each time, filtering, and combining the filtrates;
(3) and (4) evaporating and concentrating the filtrate obtained in the step (3) to remove ethanol.
4. The bone spur repairing cream containing hothe jade trace elements as claimed in claim 3, wherein the concentration of ethanol in the step (2) is 65% -85%.
5. The bone spur repairing cream containing the Hetian jade trace elements as claimed in claim 1, further comprising the following components in percentage by mass:
1-8% of methyl glucose sesquistearate, 1-8% of cetearyl alcohol, 2-6% of polydimethylsiloxane, 1-6% of caprylic/capric triglyceride, 1-6% of stearic acid, 1-4% of shea butter, 0.8-2.5% of glycerol stearate, 0.1-0.5% of carbomer, 0.1-0.3% of triethanolamine, 0.1-0.3% of phenoxyethanol and the balance of water.
CN202010701310.1A 2020-07-20 2020-07-20 Bone spur repairing cream containing Hetian jade microelements Pending CN111904996A (en)

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Application publication date: 20201110