CN111803976A - An Emulsifying Bacteria Evaporation System - Google Patents

An Emulsifying Bacteria Evaporation System Download PDF

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CN111803976A
CN111803976A CN202010742036.2A CN202010742036A CN111803976A CN 111803976 A CN111803976 A CN 111803976A CN 202010742036 A CN202010742036 A CN 202010742036A CN 111803976 A CN111803976 A CN 111803976A
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tank
section
scraper
evaporator
evaporation
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CN111803976B (en
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尹磊
丁煜
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Jiangsu Centry Engineering Technology Co ltd
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Jiangsu Centry Engineering Technology Co ltd
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D1/00Evaporating
    • B01D1/0064Feeding of liquid into an evaporator
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D1/00Evaporating
    • B01D1/06Evaporators with vertical tubes
    • B01D1/065Evaporators with vertical tubes by film evaporating
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D1/00Evaporating
    • B01D1/30Accessories for evaporators ; Constructional details thereof

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  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)

Abstract

The invention discloses an emulsifying bacterium preparation evaporation system which comprises an emulsifying section, a bacterium preparation section, an evaporation section, a quantitative transfer filtering section and a storage section which are connected by pipelines, wherein the emulsifying section comprises a water phase tank and an organic solvent tank which are mixed into an emulsifying tank in proportion; the homogenizing section is a circulating bacterium preparation section and comprises a first bacterium preparation tank, a second bacterium preparation tank and a bacterium preparation machine, wherein the first bacterium preparation tank and the second bacterium preparation tank are connected in parallel; the evaporation section comprises at least two wiped film evaporators which are connected in series and/or in parallel under the action of pipelines and valves. The invention adopts a mechanism of circulating bacteria preparation, overcomes the problem of particle size enlargement caused by insufficient bacteria preparation, adopts novel evaporation and is matched with buffer preheating to ensure the evaporation effect, and simultaneously has high product safety due to a plurality of filtering procedures before the finished product.

Description

一种乳化菌制蒸发系统An Emulsifying Bacteria Evaporation System

技术领域technical field

本发明涉及药品制备领域,特别涉及一种乳化菌制蒸发系统。The invention relates to the field of medicine preparation, in particular to an emulsification bacteria preparation evaporation system.

背景技术Background technique

在药品制备过程中,混合乳化菌制是必要的过程,但是目前现有的制备系统中,菌制过程不充分容易导致粒径变大,影响制备效果。In the pharmaceutical preparation process, mixed emulsification bacteria preparation is a necessary process, but in the current preparation system, insufficient bacteria preparation process easily leads to larger particle size and affects the preparation effect.

同时蒸发器作为制备过程中较为重要的部件,制药过程中主要采用刮板式薄膜蒸发器,其通过刮板将物料摊薄在蒸发器筒体内壁,并通过热交换的方式高效稳定的分离出有机溶剂或者是易挥发溶剂。At the same time, the evaporator is an important part in the preparation process. The scraped film evaporator is mainly used in the pharmaceutical process. The scraper thins the material on the inner wall of the evaporator cylinder, and the organic solvent is efficiently and stably separated by heat exchange. Or volatile solvents.

刮板的作用则在于将物料摊薄与筒体内壁,目前物料的进料方式是直接在筒体上开设进料口,从而刮板直接能够对物料摊薄,但是这种进料方式,进料的区域明显,无法在进料上实现均匀进料,会影响到蒸发器的分离效果。The function of the scraper is to thin the material and the inner wall of the cylinder. At present, the feeding method of the material is to open a feeding port directly on the cylinder, so that the scraper can directly thin the material. The area is obvious, and it is impossible to achieve uniform feeding on the feed, which will affect the separation effect of the evaporator.

另外,目前市面上的刮板结构主要为一体刚性刮板,固定于转子上,但是这种方案,刮板与筒壁的间距是固定,适用范围局限,但是物料在蒸发过程中受到很多因素影响,如滞留时间,自身粘度等,厚薄分布不同。In addition, the current scraper structure on the market is mainly an integrated rigid scraper, which is fixed on the rotor. However, in this scheme, the distance between the scraper and the cylinder wall is fixed, and the scope of application is limited, but the material is affected by many factors during the evaporation process. , such as residence time, self-viscosity, etc., the thickness distribution is different.

而且有的原料在前端处理再进入真空加热环境后,容易出现表面扩张,形成气泡,从真空管道逃逸,产生浪费。Moreover, some raw materials are prone to surface expansion after being processed at the front end and then entering the vacuum heating environment, forming bubbles, escaping from the vacuum pipeline, and causing waste.

故而,需要研制出一种新的药品制备系统。Therefore, there is a need to develop a new pharmaceutical preparation system.

发明内容SUMMARY OF THE INVENTION

本发明为解决上述问题,提供一种乳化菌制蒸发系统,采用循环菌制的机制,克服菌制不充分导致粒径变大的问题,更采用新型的蒸发,配以缓冲预加热,保证蒸发效果,同时在成品前多道过滤工序,产品安全性高。In order to solve the above problems, the present invention provides an emulsification bacteria preparation evaporation system, which adopts the mechanism of circulating bacteria preparation to overcome the problem that the particle size becomes larger due to insufficient bacteria preparation, and adopts a new type of evaporation, which is equipped with buffer preheating to ensure evaporation. At the same time, there are multiple filtration processes before the finished product, and the product safety is high.

并且,蒸发器通过布料器的设置,将物料采用溢流的方式实现整个筒壁的均匀进料,下料连续均匀,方便后续刮板摊薄,保证的蒸发器的分离效果稳定高效。In addition, through the setting of the distributor, the evaporator uses the overflow method to realize the uniform feeding of the entire cylinder wall, and the feeding is continuous and uniform, which is convenient for the subsequent thinning of the scraper, and the separation effect of the evaporator is guaranteed to be stable and efficient.

同时,布料器的连接上,方便快捷,稳定性高,且密封性能好,能够保证蒸发筒内的真空状态不受影响。At the same time, the connection of the distributor is convenient and fast, with high stability and good sealing performance, which can ensure that the vacuum state in the evaporation cylinder is not affected.

而刮板笼结构采用分段式的刮板结构,上下窜动并离心甩动,能够让每段刮板根据物料厚度,自我调节与筒壁间距,在离心力的作用下,更薄的压到筒壁上,增加蒸发效率。The scraper cage structure adopts a segmented scraper structure, which moves up and down and centrifugally swings, so that each section of scraper can self-adjust the distance from the cylinder wall according to the thickness of the material. On the cylinder wall, the evaporation efficiency is increased.

更者,消泡器打碎泡沫,避免因为泡沫的堆积,导致物料下降慢,同时避免原料浪费。What's more, the defoamer breaks the foam, avoids the slow decline of the material due to the accumulation of the foam, and avoids the waste of raw materials.

为达到上述目的,本发明采用的技术方案是:一种乳化菌制蒸发系统,包括管路连接的乳化段、菌制段、蒸发段、定量中转过滤段和储存段;In order to achieve the above object, the technical scheme adopted in the present invention is: an emulsification bacteria preparation evaporation system, comprising an emulsification section, a bacteria preparation section, an evaporation section, a quantitative transfer filter section and a storage section connected by pipelines;

乳化段包括水相罐和有机溶剂罐,两者按比例混合至乳化罐;The emulsification section includes an aqueous phase tank and an organic solvent tank, which are mixed in proportion to the emulsification tank;

均质段为循环菌制段,包括并联的第一菌制罐和第二菌制罐,还包括菌制机;The homogenization section is a circulating bacteria preparation section, including a first bacteria preparation tank and a second bacteria preparation tank connected in parallel, and a bacteria preparation machine;

菌制段与蒸发段之间依次设有缓冲罐和盘管预加热结构;Between the bacterial preparation section and the evaporation section, a buffer tank and a coil preheating structure are arranged in sequence;

蒸发段包括至少两台刮板式薄膜蒸发器,刮板式薄膜蒸发器之间在管道和阀门的作用下串联和/或并联;The evaporation section includes at least two wiped thin film evaporators, and the wiped thin film evaporators are connected in series and/or in parallel under the action of pipes and valves;

定量中转过滤段包括定量罐,定量罐后端通过并联的第一过滤器连接第一中转罐,第一中转罐与第二中转罐之间串联的设有第二过滤器,第二中转罐与储存段的贮存罐之间设有无菌过滤器。The quantitative transfer filter section includes a quantitative tank, the rear end of the quantitative tank is connected to the first transfer tank through a parallel first filter, a second filter is arranged in series between the first transfer tank and the second transfer tank, and the second transfer tank is connected to the second transfer tank. A sterile filter is provided between the storage tanks of the storage section.

管板式薄膜蒸发器包括蒸发器筒体和设置于蒸发器筒体上侧的驱动结构,刮板笼结构设置于蒸发器筒体内,其上侧连接于驱动结构,下侧被蒸发器筒体底部下封头上的轴承限位,下封头下侧设有出料口,蒸发器筒体侧壁设有水腔,且水腔下进上出的设有进水口和出水口,水腔外侧设有保温层,蒸发器筒体在刮板笼结构上侧的筒壁向上依次设有清洗口和真空接口,刮板笼结构相邻的蒸发器筒体筒壁上设有进料结构。The tube-plate thin film evaporator includes an evaporator cylinder and a driving structure arranged on the upper side of the evaporator cylinder. The scraper cage structure is set in the evaporator cylinder, the upper side is connected to the driving structure, and the lower side is connected to the bottom of the evaporator cylinder. The bearing on the lower head is limited, the lower side of the lower head is provided with a discharge port, the side wall of the evaporator cylinder is provided with a water cavity, and the water cavity is provided with a water inlet and a water outlet at the bottom of the water cavity. A thermal insulation layer is provided, the evaporator cylinder is provided with a cleaning port and a vacuum interface in sequence upward on the cylinder wall on the upper side of the scraper cage structure, and a feeding structure is provided on the cylinder wall of the evaporator cylinder adjacent to the scraper cage structure.

进一步地,驱动结构包括电机、驱动腔、联轴器和单端面机械密封,电机法兰固定于驱动腔顶部,作用于联轴器,驱动腔底部与蒸发器筒体上侧法兰固定,联轴器与刮板笼结构固定。Further, the driving structure includes a motor, a driving cavity, a coupling and a single-end mechanical seal. The motor flange is fixed on the top of the driving cavity and acts on the coupling. The bottom of the driving cavity is fixed with the flange on the upper side of the evaporator cylinder, and is connected to the evaporator. The shaft is fixed with the scraper cage structure.

进一步地,刮板笼结构包括中心转和固定于中心转轴上下侧的上卡盘和下卡盘,上卡盘与所述下卡盘之间设有至少三道刮板固定轴,刮板固定轴叠合套设有多个中空的圆柱刮板,且圆柱刮板与刮板固定轴之间存在偏移量,圆柱刮板边缘位置凸出于上卡盘和下卡盘,中心转轴穿过蒸发器筒体后与联轴器固定,且单端面机械密封在法兰连接处作用。Further, the scraper cage structure includes a center rotation and an upper chuck and a lower chuck that are fixed on the upper and lower sides of the central rotating shaft. There are at least three scraper fixing shafts between the upper chuck and the lower chuck, and the scrapers are fixed. The shaft stacking sleeve is provided with a plurality of hollow cylindrical scrapers, and there is an offset between the cylindrical scraper and the fixed shaft of the scraper, the edge position of the cylindrical scraper protrudes from the upper chuck and the lower chuck, and the central rotating shaft passes through The evaporator cylinder is fixed with the coupling, and the single-end mechanical seal acts at the flange connection.

进一步地,所述最顶侧的所述圆柱刮板与上卡盘之间间距为2-5mm,刮板固定轴设置数量为4,且在周部均分上卡盘和下卡盘。Further, the distance between the cylindrical scraper on the topmost side and the upper chuck is 2-5mm, and the number of fixing shafts of the scraper is 4, and the upper chuck and the lower chuck are equally divided on the circumference.

进一步地,中心转轴在上卡盘上侧还设有消泡器,消泡器为对称的桨叶结构,其桨叶上均布有锥形通孔。Further, the central rotating shaft is also provided with a defoamer on the upper side of the upper chuck, and the defoamer is a symmetrical paddle structure with conical through holes evenly distributed on the paddles.

进一步地,进料结构包括设置于蒸发器筒体的上筒体和下筒体之间且密封固定的布料器,上筒体底部的第一连接法兰与下筒体顶部的第二连接法兰用于布料器的上下限位固定,布料器圆周侧壁均分的设有至少三个进料口,布料器上侧面由外至内的设有第一连接止口、进料槽和溢流堰,下侧面设有第二连接止口,中部为贯通的出料口,出料口边缘与上筒体、下筒体内壁持平,进料口与设置与进料槽内的进料内出口连通。Further, the feeding structure includes a distributor that is arranged between the upper cylinder and the lower cylinder of the evaporator cylinder and is sealed and fixed, and the first connecting flange at the bottom of the upper cylinder and the second connection method at the top of the lower cylinder. The blue is used to fix the upper and lower limit of the distributor. At least three feeding ports are equally divided on the circumferential side wall of the distributor. The upper side of the distributor is provided with a first connection stop, a feeding slot and an overflow from the outside to the inside. The flow weir is provided with a second connection stop on the lower side, and the middle part is a through discharge port. The edge of the discharge port is flush with the inner wall of the upper cylinder and the lower cylinder. Exit connection.

进一步地,第一连接止口和第二连接止口内设有密封圈用于密封,溢流堰上均布有溢流缺口。Further, a sealing ring is provided in the first connection stop and the second connection stop for sealing, and overflow gaps are evenly distributed on the overflow weir.

进一步地,进料口设置个数为4,布料器边缘等分的设有连接孔,连接螺栓穿过连接孔将布料器与第一连接法兰和第二连接法兰固定。Further, the number of feeding ports is 4, the edge of the distributor is equally divided with connecting holes, and the connecting bolts pass through the connecting holes to fix the distributor with the first connecting flange and the second connecting flange.

进一步地,驱动腔内还设有角接触轴承在联轴器下侧作用于中心转轴。Further, an angular contact bearing is also provided in the drive cavity to act on the central rotating shaft on the lower side of the coupling.

进一步地,菌制机为高压微射流菌制机。Further, the bacteria preparation machine is a high pressure microfluidic bacteria preparation machine.

综上所述,本发明具备如下优点:To sum up, the present invention has the following advantages:

本发明采用循环菌制的机制,克服菌制不充分导致粒径变大的问题,更采用新型的蒸发,配以缓冲预加热,保证蒸发效果,同时在成品前多道过滤工序,产品安全性高。The invention adopts the mechanism of circulating bacteria preparation to overcome the problem of insufficient bacteria preparation leading to larger particle size, and adopts a new type of evaporation, which is matched with buffer preheating to ensure the evaporation effect. high.

布料器的设置,将物料采用溢流的方式实现整个筒壁的均匀进料,下料连续均匀,方便后续刮板摊薄,保证的蒸发器的分离效果稳定高效。The setting of the distributor allows the material to be overflowed to realize the uniform feeding of the entire cylinder wall, and the feeding is continuous and uniform, which is convenient for the subsequent thinning of the scraper, and ensures that the separation effect of the evaporator is stable and efficient.

同时,布料器的连接上,方便快捷,稳定性高,且密封性能好,能够保证蒸发筒内的真空状态不受影响。At the same time, the connection of the distributor is convenient and fast, with high stability and good sealing performance, which can ensure that the vacuum state in the evaporation cylinder is not affected.

而刮板笼结构采用分段式的刮板结构,上下窜动并离心甩动,能够让每段刮板根据物料厚度,自我调节与筒壁间距,在离心力的作用下,更薄的压到筒壁上,增加蒸发效率。The scraper cage structure adopts a segmented scraper structure, which moves up and down and centrifugally swings, so that each section of scraper can self-adjust the distance from the cylinder wall according to the thickness of the material. On the cylinder wall, the evaporation efficiency is increased.

更者,消泡器打碎泡沫,避免因为泡沫的堆积,导致物料下降慢,同时避免原料浪费。What's more, the defoamer breaks the foam, avoids the slow decline of the material due to the accumulation of the foam, and avoids the waste of raw materials.

附图说明Description of drawings

图1是刮板式薄膜蒸发器结构示意图;Fig. 1 is the structure schematic diagram of scraper type thin film evaporator;

图2是布料器结构示意图;Fig. 2 is a schematic diagram of the structure of the distributor;

图3是进料结构示意图;Fig. 3 is the schematic diagram of feed structure;

图4是刮板笼结构示意图;Figure 4 is a schematic diagram of a scraper cage structure;

图5是A部放大图;Figure 5 is an enlarged view of part A;

图6是本发明结构示意图。Figure 6 is a schematic view of the structure of the present invention.

具体实施方式Detailed ways

下面结合附图及实施例对本发明作进一步描述:Below in conjunction with accompanying drawing and embodiment, the present invention is further described:

实施例1:Example 1:

一种乳化菌制蒸发系统,如图1-6所示,包括管路连接的乳化段、菌制段、蒸发段、定量中转过滤段和储存段。An emulsification bacteria-based evaporation system, as shown in Figure 1-6, includes an emulsification section, a bacteria preparation section, an evaporation section, a quantitative transfer filter section and a storage section connected by pipelines.

其中,乳化段包括水相罐100和有机溶剂罐200,两者按比例混合至乳化罐300;结合具体案例说明,在本实施例中,可以选择水相与有机相10:1混合。The emulsification section includes an aqueous phase tank 100 and an organic solvent tank 200, which are mixed in proportion to the emulsification tank 300; in conjunction with specific case descriptions, in this embodiment, a 10:1 mixing of the aqueous phase and the organic phase can be selected.

均质段为循环菌制段,包括并联的第一菌制罐400和第二菌制罐500,还包括菌制机600,菌制机600高压微射流菌制机,菌制过程,乳化罐的出料进入第一菌制罐,随后菌制机菌制反向进入第二菌制罐和第一菌制罐,重复循环至充分后进入菌制段与蒸发段之间的缓冲罐700,随后经盘管预加热结构800作用进入蒸发段。The homogenization section is a circulating bacteria preparation section, including a first bacteria preparation tank 400 and a second bacteria preparation tank 500 in parallel, and also includes a bacteria preparation machine 600, a bacteria preparation machine 600, a high pressure micro-jet bacteria preparation machine, a bacteria preparation process, and an emulsification tank. The discharged material enters the first bacterial production tank, and then the bacterial production mechanism reversely enters the second bacterial production tank and the first bacterial production tank, and is repeatedly circulated to the buffer tank 700 between the bacterial production section and the evaporation section after being fully circulated, Then, it enters the evaporation section through the action of the coil preheating structure 800 .

蒸发段包括至少两台刮板式薄膜蒸发器900,在本实施例中为两台,刮板式薄膜蒸发器900之间在管道和阀门的作用下串联和/或并联。The evaporation section includes at least two wiped thin film evaporators 900, two in this embodiment, and the wiped thin film evaporators 900 are connected in series and/or in parallel under the action of pipes and valves.

则前侧的蒸发器蒸发完成后能够进入后端的蒸发器或是直接进入后道工序,该串联和并联的选择根据制备产品特效和蒸发量选择。Then the evaporator on the front side can enter the evaporator at the back end or directly into the subsequent process after the evaporation is completed.

蒸发完成后进入定量中转过滤段。After the evaporation is completed, it enters the quantitative transfer filter section.

定量中转过滤段包括定量罐1000,定量罐1000后端通过并联的第一过滤器1100连接第一中转罐1200,为粗过滤段。The quantitative transfer filter section includes a quantitative tank 1000, and the rear end of the quantitative tank 1000 is connected to the first transfer tank 1200 through a parallel first filter 1100, which is a coarse filter section.

第一中转罐100与第二中转罐1300之间串联的设有第二过滤器1400,为精过滤段。A second filter 1400 is arranged in series between the first transfer tank 100 and the second transfer tank 1300, which is a fine filter section.

第二中转罐1300与储存段的贮存罐1500之间设有无菌过滤器1600,为无菌过滤段。A sterile filter 1600 is provided between the second transfer tank 1300 and the storage tank 1500 of the storage section, which is a sterile filter section.

在蒸发器的设置上,刮板式薄膜蒸发器包括蒸发器筒体1和设置于蒸发器筒体1上侧的驱动结构2,刮板笼结构3设置于蒸发器筒体1内,其上侧连接于驱动结构2,下侧被蒸发器筒体1底部下封头11上的轴承12限位,下封头11下侧设有出料口13。In the setting of the evaporator, the wiper type thin film evaporator includes an evaporator cylinder 1 and a driving structure 2 arranged on the upper side of the evaporator cylinder 1. The scraper cage structure 3 is arranged in the evaporator cylinder 1, and its upper side is Connected to the driving structure 2, the lower side is limited by the bearing 12 on the lower head 11 at the bottom of the evaporator cylinder 1, and the lower head 11 is provided with a discharge port 13 on the lower side.

在换热机制上,蒸发器筒体1侧壁设有水腔4,且水腔4下进上出的设有进水口41和出水口42,即换热液体下进上出。In terms of heat exchange mechanism, the side wall of the evaporator cylinder 1 is provided with a water cavity 4, and the water cavity 4 is provided with a water inlet 41 and a water outlet 42, that is, the heat exchange liquid enters and exits from the bottom.

水腔4外侧设有保温层5,保证较优的换热效果。An insulating layer 5 is provided on the outer side of the water cavity 4 to ensure a better heat exchange effect.

蒸发器筒体1在刮板笼结构3上侧的筒壁向上依次设有清洗口14和真空接口15,清洗口14用于蒸发器筒体内部的清洁,真空接口用于蒸发过程中的抽真空。The evaporator cylinder 1 is provided with a cleaning port 14 and a vacuum port 15 on the upper side of the cylinder wall of the scraper cage structure 3 in order. vacuum.

在进料设置上,刮板笼结构3相邻的蒸发器筒体1筒壁上设有进料结构6。In the feeding setting, a feeding structure 6 is provided on the cylinder wall of the evaporator cylinder 1 adjacent to the scraper cage structure 3 .

进料结构包括设置于蒸发器筒体1的上筒体6-1和下筒体6-2之间且密封固布料器6-3。The feeding structure includes a distributor 6-3 which is arranged between the upper cylinder 6-1 and the lower cylinder 6-2 of the evaporator cylinder 1 and is sealed and fixed.

具体的,上筒体6-1底部的第一连接法兰6-11与下筒体6-2顶部的第二连接法兰6-21用于布料器6-3的上下限位固定,而布料器6-3边缘等分的设有连接孔6-38,连接螺栓6-5穿过连接孔6-38将布料器6-3与第一连接法兰6-11和第二连接法兰6-21固定。Specifically, the first connection flange 6-11 at the bottom of the upper cylinder 6-1 and the second connection flange 6-21 at the top of the lower cylinder 6-2 are used for the upper and lower limit fixing of the distributor 6-3, while The edge of the distributor 6-3 is equally divided with connecting holes 6-38, and the connecting bolts 6-5 pass through the connecting holes 6-38 to connect the distributor 6-3 with the first connecting flange 6-11 and the second connecting flange 6-21 fixed.

继续参照附图2,布料器6-3圆周侧壁均分的设有至少三个进料口6-31,在本实施例中设置个数为4,布料器6-3上侧面由外至内的设有第一连接止口6-32、进料槽6-33和溢流堰6-34,下侧面设有第二连接止口6-35,中部为贯通的出料口6-36,第一连接止口6-32和所述第二连接止口6-35内设有密封圈6-4用于密封,即在上下的连接法兰与布料器固定时,能够实现上筒体,下筒体和布料器的密封连接。Continue to refer to Fig. 2, the circumferential side wall of the distributor 6-3 is evenly provided with at least three feeding ports 6-31, in this embodiment, the number is 4, and the upper side of the distributor 6-3 is from outside to The inner one is provided with a first connection stop 6-32, a feeding slot 6-33 and an overflow weir 6-34, a second connection stop 6-35 is arranged on the lower side, and a through-out outlet 6-36 is located in the middle. , the first connection stop 6-32 and the second connection stop 6-35 are provided with a sealing ring 6-4 for sealing, that is, when the upper and lower connection flanges are fixed with the distributor, the upper cylinder can be realized. , the sealing connection between the lower cylinder and the distributor.

在出料设置上,为保证出料能够直接作用于筒壁,出料口6-36边缘与上筒体6-1、下筒体6-2内壁持平,即圆环设置的溢流堰外侧端与筒体内壁持平。In the discharge setting, in order to ensure that the discharge can directly act on the cylinder wall, the edge of the discharge port 6-36 is flush with the inner walls of the upper cylinder body 6-1 and the lower cylinder body 6-2, that is, the outer side of the overflow weir set in the ring The end is flush with the inner wall of the cylinder.

而进料口6-31与设置与进料槽6-33内的进料内出口6-37连通,从而进料能够进入进料槽后经溢流堰出料。The feeding port 6-31 is connected with the feeding inner outlet 6-37 arranged in the feeding groove 6-33, so that the feeding material can enter the feeding groove and then discharge through the overflow weir.

值得注意的是,溢流堰上均布有溢流缺口,该溢流缺口为齿状的溢流孔。It is worth noting that there are overflow gaps evenly distributed on the overflow weir, and the overflow gaps are tooth-shaped overflow holes.

在其工作机制上,布料器独立于蒸发器筒体,装配在蒸发器筒体上部,物料经进料口进入内部的进料槽,随后在溢流堰上缓缓流出,挂载内壁自流到筒体,蒸发器筒体内的刮板摊薄。In terms of its working mechanism, the distributor is independent of the evaporator cylinder and is assembled on the upper part of the evaporator cylinder. The material enters the internal feed tank through the feed port, and then flows out slowly on the overflow weir, and is mounted on the inner wall to flow to the Cylinder, the scraper in the evaporator cylinder is thinned.

在驱动结构的设置上,驱动结构2包括电机21、驱动腔22、联轴器23和单端面机械密封24。In the setting of the driving structure, the driving structure 2 includes a motor 21 , a driving cavity 22 , a coupling 23 and a single-end mechanical seal 24 .

电机法兰固定于驱动腔22顶部,作用于联轴器23,驱动腔22底部与蒸发器筒体1上侧法兰固定,联轴器23与刮板笼结构3固定。The motor flange is fixed on the top of the drive cavity 22 and acts on the coupling 23 . The bottom of the drive cavity 22 is fixed with the upper flange of the evaporator cylinder 1 , and the coupling 23 is fixed with the scraper cage structure 3 .

在刮板笼的设置上,刮板笼结构包括中心转轴3-1和固定于中心转轴3-1上下侧的上卡盘3-11和下卡盘3-12。In the setting of the scraper cage, the scraper cage structure includes a central rotating shaft 3-1 and an upper chuck 3-11 and a lower chuck 3-12 fixed on the upper and lower sides of the central rotating shaft 3-1.

上卡盘3-11与下卡盘3-12为镂空圆盘结构,两者之间设有至少三道刮板固定轴3-3,在本实施例中设置为四道,且在周部均分上卡盘3-11和下卡盘3-12。The upper chuck 3-11 and the lower chuck 3-12 are hollow disc structures, and at least three scraper fixing shafts 3-3 are arranged between them, in this embodiment, there are four, and at the periphery Divide the upper chuck 3-11 and the lower chuck 3-12 equally.

刮板固定轴3-3叠合套设有多个中空的圆柱刮板3-4,且圆柱刮板3-4与刮板固定轴3-3之间存在偏移量,同时,最顶侧的圆柱刮板3-4与上卡盘3-11之间间距为2-5mm,从而能够使得刮板在工作过程中自我调节。The scraper fixing shaft 3-3 is overlapped with a plurality of hollow cylindrical scrapers 3-4, and there is an offset between the cylindrical scraper 3-4 and the scraper fixing shaft 3-3. The distance between the cylindrical scraper 3-4 and the upper chuck 3-11 is 2-5mm, so that the scraper can self-adjust during the working process.

并且,圆柱刮板3-4边缘位置凸出于上卡盘3-11和下卡盘3-12。In addition, the edge position of the cylindrical scraper 3-4 protrudes from the upper chuck 3-11 and the lower chuck 3-12.

中心转轴3-1穿过所述蒸发器筒体1后与联轴器23固定,且单端面机械密封24在法兰连接处作用。The central rotating shaft 3-1 is fixed with the coupling 23 after passing through the evaporator cylinder 1, and the single-end mechanical seal 24 acts at the flange connection.

驱动腔22内还设有角接触轴承221在联轴器23下侧作用于中心转轴3-1,该设置能够对中心转轴在工作过程自我调节,起到防偏的作用且受力更大。The drive cavity 22 is also provided with an angular contact bearing 221 on the lower side of the coupling 23 to act on the central shaft 3-1. This setting can self-adjust the central shaft during the working process, play an anti-bias role and bear greater force.

同时中心转轴在上卡盘3-11上侧还设有消泡器3-5。At the same time, a defoamer 3-5 is also provided on the upper side of the upper chuck 3-11 on the central rotating shaft.

具体的,消泡器3-5为对称的桨叶结构,其桨叶上均布有锥形通孔3-51。Specifically, the defoamer 3-5 is a symmetrical paddle structure, and the paddles are uniformly distributed with conical through holes 3-51.

中心转轴在电机的作用下转动,即电机带动联轴器,从而带动中心转轴转动,具体的,中心转轴在下侧被下封头上的轴承限位,故而圆柱刮板可以上下串动,且做离心式的甩动,物料从进料结构采用溢流的方式进入蒸发器筒体,并被摊薄,同时在水腔的作用下,换热蒸发。The central rotating shaft rotates under the action of the motor, that is, the motor drives the coupling, thereby driving the central rotating shaft to rotate. Specifically, the central rotating shaft is limited by the bearing on the lower head on the lower side, so the cylindrical scraper can move up and down in series. Centrifugal shaking, the material flows into the evaporator cylinder from the feed structure by means of overflow, and is diluted, and at the same time, under the action of the water cavity, heat exchange and evaporation.

具体的,物料从消泡器下侧的刮板与筒壁之间进入蒸发器的筒体内,蒸发器工作时,筒体内由于真空泵的作用处于真空状态,有的原料,经过前端工艺后,再进入真空环境的加热之后,溶剂类容易出现表面张力扩张,类似吹肥皂泡一样,产生泡沫。Specifically, the material enters the cylinder of the evaporator from between the scraper on the lower side of the defoamer and the cylinder wall. When the evaporator is working, the cylinder is in a vacuum state due to the action of the vacuum pump. After heating in a vacuum environment, the solvent is prone to surface tension expansion, which is similar to blowing soap bubbles to generate foam.

泡沫会携带一部分原料从真空管道处逃逸,造成浪费,同时筒体内也会因为泡沫堆积,导致物料下降较慢,此时在消泡器的作用下,泡沫会从锥形孔的大孔侧被刮入锥形孔内,再从锥形底的小孔里挤出,泡沫在这里循环被打散,就会破碎下落,过程中溶剂类会因为受热蒸发随真空而出,液体原料下落。The foam will carry a part of the raw material and escape from the vacuum pipe, causing waste. At the same time, the foam will accumulate in the cylinder, causing the material to fall slowly. At this time, under the action of the defoamer, the foam will be removed from the large hole side of the conical hole. Scraped into the conical hole, and then extruded from the small hole of the conical bottom, the foam is circulated and dispersed here, and it will be broken and fall.

本方案中,圆柱刮板的直径、长度、重量,根据蒸发器的规格、蒸发面积、筒体直径而确定,越小规格的蒸发器,刮板尺寸会更小,刮板的重量和长度,一般根据物料才决定,越粘稠的物料,刮板越长,重量也越重。In this scheme, the diameter, length and weight of the cylindrical scraper are determined according to the specifications of the evaporator, the evaporation area, and the diameter of the cylinder. Generally, it is determined according to the material. The more viscous the material, the longer the scraper and the heavier the weight.

刮板通过改变壁厚和长度,来改变刮板的重量,为了不影响刮板的效率,壁厚和长度改变的话,刮板轴的旋转直径,也要改变。The scraper changes the weight of the scraper by changing the wall thickness and length. In order not to affect the efficiency of the scraper, if the wall thickness and length change, the rotating diameter of the scraper shaft should also be changed.

一般来说,刮板偏重、偏长一点,对使用效果会好一点。Generally speaking, the scraper is heavier and longer, and the effect will be better.

而且,分段式刮板的优势,在于每一段的刮板,到筒体内部的距离,是可以自我调节的。Moreover, the advantage of the segmented scraper is that the distance between the scraper of each section and the interior of the cylinder can be adjusted by itself.

比如某一段筒体内壁的物料,因为滞留时间和粘度原因,厚了一点,那么这段的刮板工作的时候,距离筒壁自然间距就大一点。For example, the material on the inner wall of a certain section of the cylinder is thicker due to the residence time and viscosity, so when the scraper in this section is working, the natural distance from the cylinder wall is larger.

同理,如果筒壁其他地方的物料很薄,那么因为离心力的作用,刮板自然就会压向筒壁,间距就会自我缩小,这样就可以让每段刮板,根据物料的厚度,自我调节自身和筒壁的距离,尽可能的把物料通过中心轴转动产生的离心力,更薄的压到筒壁上,增加蒸发效率。In the same way, if the material in other parts of the cylinder wall is very thin, then because of the centrifugal force, the scraper will naturally be pressed against the cylinder wall, and the spacing will shrink by itself, so that each section of the scraper can be adjusted according to the thickness of the material. Adjust the distance between itself and the cylinder wall, as much as possible to press the centrifugal force generated by the rotation of the material through the central axis to the cylinder wall thinner to increase the evaporation efficiency.

综上所述,本方案采用循环菌制的机制,克服菌制不充分导致粒径变大的问题,更采用新型的蒸发,配以缓冲预加热,保证蒸发效果,同时在成品前多道过滤工序,产品安全性高。To sum up, this scheme adopts the mechanism of cyclic bacterial preparation to overcome the problem of insufficient bacterial preparation leading to larger particle size. It also adopts a new type of evaporation, with buffer preheating to ensure the evaporation effect, and at the same time, multiple filtration before the finished product. process, product safety is high.

蒸发器通过布料器的设置,将物料采用溢流的方式实现整个筒壁的均匀进料,下料连续均匀,方便后续刮板摊薄,保证的蒸发器的分离效果稳定高效。Through the setting of the distributor, the evaporator uses the overflow method to realize the uniform feeding of the entire cylinder wall, and the feeding is continuous and uniform, which is convenient for the subsequent thinning of the scraper, and ensures that the separation effect of the evaporator is stable and efficient.

同时,布料器的连接上,方便快捷,稳定性高,且密封性能好,能够保证蒸发筒内的真空状态不受影响。At the same time, the connection of the distributor is convenient and fast, with high stability and good sealing performance, which can ensure that the vacuum state in the evaporation cylinder is not affected.

而刮板笼结构采用分段式的刮板结构,上下窜动并离心甩动,能够让每段刮板根据物料厚度,自我调节与筒壁间距,在离心力的作用下,更薄的压到筒壁上,增加蒸发效率。The scraper cage structure adopts a segmented scraper structure, which moves up and down and centrifugally swings, so that each section of scraper can self-adjust the distance from the cylinder wall according to the thickness of the material. On the cylinder wall, the evaporation efficiency is increased.

更者,消泡器打碎泡沫,避免因为泡沫的堆积,导致物料下降慢,同时避免原料浪费。What's more, the defoamer breaks the foam, avoids the slow decline of the material due to the accumulation of the foam, and avoids the waste of raw materials.

上述实施方式只为说明本发明的技术构思及特点,其目的在于让熟悉此项技术的人能够了解本发明的内容并据以实施,并不能以此限制本发明的保护范围。凡根据本发明精神实质所做的等效变换或修饰,都应涵盖在本发明的保护范围之内。The above-mentioned embodiments are only intended to illustrate the technical concept and features of the present invention, and the purpose is to enable those who are familiar with the art to understand the content of the present invention and implement it accordingly, and cannot limit the protection scope of the present invention. All equivalent transformations or modifications made according to the spirit of the present invention should be covered within the protection scope of the present invention.

在本发明的描述中,需要说明的是,除非另有明确的规定和限定,术语“安装”、“相连”、“连接”应做广义理解,例如,可以是固定连接,也可以是可拆卸连接,或一体地连接;可以是机械连接,也可以是电连接;可以是直接相连,也可以通过中间媒介间接相连,可以是两个元件内部的连通。In the description of the present invention, it should be noted that the terms "installed", "connected" and "connected" should be understood in a broad sense, unless otherwise expressly specified and limited, for example, it may be a fixed connection or a detachable connection Connection, or integral connection; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, can be internal communication between two elements.

对于本领域的普通技术人员而言,可以具体情况理解上述术语在本发明中的具体含义。For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood in specific situations.

应当理解,上述的实施方式仅是示例性的,而非限制性的,在不偏离本发明的基本原理的情况下,本领域的技术人员可以针对上述细节做出的各种明显的或等同的修改或替换,都将包含于本发明的权利要求范围内。It should be understood that the above-mentioned embodiments are only exemplary rather than restrictive, and those skilled in the art can make various obvious or equivalent to the above-mentioned details without departing from the basic principles of the present invention. Modifications or substitutions will be included within the scope of the claims of the present invention.

Claims (10)

1. An emulsification bacterium system vaporization system which characterized in that: comprises an emulsifying section, a bacterium preparation section, an evaporation section, a quantitative transfer filtering section and a storage section which are connected by pipelines;
the emulsification section comprises a water phase tank (100) and an organic solvent tank (200), and the water phase tank and the organic solvent tank are mixed into an emulsification tank (300) according to a proportion;
the homogenizing section is a circulating bacteria preparation section and comprises a first bacteria preparation tank (400) and a second bacteria preparation tank (500) which are connected in parallel and a bacteria preparation machine (600);
a buffer tank (700) and a coil preheating structure (800) are sequentially arranged between the bacterium preparation section and the evaporation section;
the evaporation section comprises at least two wiped film evaporators (900), and the wiped film evaporators (900) are connected in series and/or in parallel under the action of pipelines and valves;
the quantitative transfer filtering section comprises a quantitative tank (1000), the rear end of the quantitative tank (1000) is connected with a first transfer tank (1200) through a first filter (1100) connected in parallel, a second filter (1400) is arranged between the first transfer tank (1100) and a second transfer tank (1300) in series, and an aseptic filter (1600) is arranged between the second transfer tank (1300) and a storage tank (1500) of the storage section.
2. The evaporation system for emulsifying bacteria according to claim 1, wherein: the wiped film evaporator (900) comprises an evaporator cylinder (1) and a driving structure (2) arranged on the upper side of the evaporator cylinder (1), a scraper cage structure (3) is arranged in the evaporator cylinder (1), the upper side of the evaporator is connected with the driving structure (2), the lower side of the evaporator is limited by a bearing (12) on a lower end enclosure (11) at the bottom of the evaporator cylinder body (1), a discharge hole (13) is arranged at the lower side of the lower end enclosure (11), a water cavity (4) is arranged on the side wall of the evaporator cylinder body (1), a water inlet (41) and a water outlet (42) are arranged at the lower part, the upper part and the lower part of the water cavity (4), a heat-insulating layer (5) is arranged on the outer side of the water cavity (4), a cleaning opening (14) and a vacuum interface (15) are sequentially arranged on the upper side of the scraper cage structure (3) of the evaporator cylinder body (1) in an upward direction, and a feeding structure (6) is arranged on the wall of the evaporator barrel (1) adjacent to the scraper cage structure (3).
3. The evaporation system for emulsifying bacteria according to claim 2, wherein: drive structure (2) include motor (21), drive chamber (22), shaft coupling (23) and single-end face mechanical seal (24), the motor flange is fixed in drive chamber (22) top acts on shaft coupling (23), drive chamber (22) bottom with evaporimeter barrel (1) upside flange is fixed, shaft coupling (23) with scraper blade cage structure (3) are fixed.
4. The evaporation system made of emulsifying bacteria according to claim 3, characterized in that: the scraper plate cage structure (3) comprises a central rotating shaft (3-1) and an upper chuck (3-11) and a lower chuck (3-12) which are fixed on the upper side and the lower side of the central rotating shaft (3-1), at least three scraper plate fixing shafts (3-3) are arranged between the upper chuck (3-11) and the lower chuck (3-12), a plurality of hollow cylindrical scraper plates (3-4) are sleeved on the scraper plate fixing shafts (3-3) in an overlapped mode, offset exists between the cylindrical scraper plates (3-4) and the scraper plate fixing shafts (3-3), the edge positions of the cylindrical scraper plates (3-4) protrude out of the upper chuck (3-11) and the lower chuck (3-12), the central rotating shaft (3-1) penetrates through the evaporator cylinder body (1) and then is fixed with the coupler (23), and the single-ended mechanical seal (24) acts at the flange connection;
the distance between the cylindrical scraper (3-4) at the top side and the upper chuck (3-11) is 2-5mm, the number of the scraper fixing shafts (3-3) is 4, and the upper chuck (3-11) and the lower chuck (3-12) are uniformly distributed on the periphery.
5. The evaporation system made of emulsifying bacteria according to claim 3, characterized in that: the upper side of the upper chuck (3-11) of the central rotating shaft (3-1) is also provided with a defoamer (3-5), the defoamer (3-5) is of a symmetrical blade structure, and conical through holes (3-51) are uniformly distributed on blades of the defoamer.
6. The evaporation system for emulsifying bacteria according to claim 1, wherein: the feeding structure (6) comprises a distributing device (6-3) which is arranged between an upper barrel (6-1) and a lower barrel (6-2) of the evaporator barrel (1) and is fixed in a sealing way, a first connecting flange (6-11) at the bottom of the upper barrel (6-1) and a second connecting flange (6-21) at the top of the lower barrel (6-2) are used for upper and lower limiting and fixing of the distributing device (6-3), the circumferential side wall of the distributing device (6-3) is equally divided and provided with at least three feeding holes (6-31), the upper side surface of the distributing device (6-3) is provided with a first connecting spigot (6-32), a feeding groove (6-33) and an overflow weir (6-34) from outside to inside, the lower side surface is provided with a second connecting spigot (6-35), the middle part is provided with a through discharge hole (6-36), the edge of the discharge hole (6-36) is level with the inner walls of the upper cylinder body (6-1) and the lower cylinder body (6-2), and the feed inlet (6-31) is communicated with a feed inner outlet (6-37) arranged in the feed chute (6-33).
7. The evaporation system made of emulsifying bacteria according to claim 6, characterized in that: sealing rings (6-4) are arranged in the first connecting spigot (6-32) and the second connecting spigot (6-35) for sealing, and overflow gaps are uniformly distributed on the overflow weir (6-34).
8. The evaporation system made of emulsifying bacteria according to claim 6, characterized in that: the number of the feeding holes is 4, connecting holes (6-38) are formed in the edge of the distributing device (6-3) in an equal dividing mode, and connecting bolts (6-5) penetrate through the connecting holes (6-38) to fix the distributing device (6-3) with the first connecting flange (6-11) and the second connecting flange (6-21).
9. The evaporation system made of emulsifying bacteria according to claim 4, wherein: an angular contact bearing (221) is further arranged in the driving cavity (22) and acts on the central rotating shaft (3-1) at the lower side of the coupler (23).
10. The evaporation system for emulsifying bacteria according to claim 1, wherein: the sterilization machine (600) is a high-pressure micro-jet sterilization machine.
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CN203763873U (en) * 2013-09-16 2014-08-13 苏州岑途工程技术有限公司 Movable scraper plate for vertical evaporator
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CN113713411A (en) * 2021-09-23 2021-11-30 宜昌诚凯化工科技有限公司 Phosphorous acid film evaporation system
CN113713411B (en) * 2021-09-23 2024-02-09 宜昌诚凯化工科技有限公司 Phosphorous acid film evaporation system
CN116637541A (en) * 2023-06-01 2023-08-25 苏州岑途智能装备科技股份有限公司 System for preparing pharmaceutical preparation

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