CN111659257A - Dialysis device - Google Patents

Dialysis device Download PDF

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Publication number
CN111659257A
CN111659257A CN202010504558.9A CN202010504558A CN111659257A CN 111659257 A CN111659257 A CN 111659257A CN 202010504558 A CN202010504558 A CN 202010504558A CN 111659257 A CN111659257 A CN 111659257A
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CN
China
Prior art keywords
dialysis
clamping
cylinder
air cylinder
fixed
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Pending
Application number
CN202010504558.9A
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Chinese (zh)
Inventor
彭钢
李薇
孔德起
刘剑
谭雄文
赖华
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Hengyang Normal University
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Hengyang Normal University
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Priority to CN202010504558.9A priority Critical patent/CN111659257A/en
Publication of CN111659257A publication Critical patent/CN111659257A/en
Pending legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24Dialysis ; Membrane extraction
    • B01D61/28Apparatus therefor

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  • Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • External Artificial Organs (AREA)

Abstract

A dialysis device comprises a driving mechanism, a plurality of transverse rods and a plurality of clamping devices, wherein the driving mechanism comprises a vertically arranged air cylinder, the air cylinder can rotate along the central axis of the air cylinder, and the top of the air cylinder is symmetrically provided with the plurality of transverse rods; the clamping mechanism is arranged at the end part of the cross rod and comprises a clamping cylinder capable of rotating on a vertical surface, and the top end of the clamping cylinder is connected with a clamping head; the dialysis mechanism is arranged below the clamping mechanism and comprises a plurality of magnetic stirrers arranged along the circumferential direction of the air cylinder, the magnetic stirrers can move along the radial direction of the air cylinder, a dialysis cup is arranged on each magnetic stirrer, and a rotor is arranged in each dialysis cup. The dialysis bag is clamped by the clamping head, the dialysis bag is completely immersed into dialysate when the cylinder contracts, the dialysis efficiency is improved, and the dialysis bag is successively immersed into different dialysis cups by the rotation and the lifting of the cylinder, so that the automatic multi-stage dialysis is realized.

Description

Dialysis device
Technical Field
The invention relates to the field of chemical equipment, in particular to a dialysis device.
Background
Dialysis devices are commonly used in the chemical field, and the principle of dialysis devices is to utilize the difference of the size, shape, property and the like of solute molecules in a solution to show different permeabilities for a separation membrane, so as to achieve the purpose of separation. When the common small-size dialysis unit in laboratory used, the accessible stirring was changed fresh dialysate regularly and is improved the dialysis effect.
Dialysis device generally adopts the dialysis bag to press from both sides the dialysis bag that will be equipped with the sample when using sealed, then places in the dislysate, because sealed clamp is mostly plastic products, is difficult to sink into the dislysate bottom, and the dialysis efficiency is low, and current dialysis device can not realize changing the dislysate automatically, needs artifical periodic replacement, and degree of automation is low.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a dialysis device, which is characterized in that a dialysis bag is clamped by a clamping head, the dialysis bag is completely immersed into dialysate when an air cylinder contracts, the dialysis efficiency is improved, and the dialysis bag is gradually immersed into different dialysis cups by the rotation and the lifting of the air cylinder, so that the automatic multi-stage dialysis is realized.
In order to achieve the above object, the present invention employs the following techniques:
a dialysis device, comprising:
the driving mechanism comprises a vertically arranged cylinder, the cylinder can rotate along the central axis of the cylinder, and a plurality of cross rods are symmetrically arranged at the top of the cylinder;
the clamping mechanism is arranged at the end part of the cross rod and comprises a clamping cylinder capable of rotating on a vertical surface, and the top end of the clamping cylinder is connected with a clamping head;
the dialysis mechanism is arranged below the clamping mechanism and comprises a plurality of magnetic stirrers arranged along the circumferential direction of the air cylinder, the magnetic stirrers can move along the radial direction of the air cylinder, a dialysis cup is arranged on each magnetic stirrer, and a rotor is arranged in each dialysis cup.
Further, the cylinder bottom rotates and is connected with the flat board, and cylinder bottom circumference is equipped with annular rack bar, and annular rack bar cooperation has the gear, gear connection driving motor, and driving motor locates the flat board below.
Further, the cross bar is fixed to the top of the cylinder through screws.
Furthermore, the clamping cylinder is provided with a base and a telescopic rod, the bottom end of the base is connected with an annular block, a driving block is matched in the annular block and connected with a clamping motor, and the clamping motor is fixed on the cross rod.
Furthermore, the clamping head is provided with a fixed clamping plate and a movable clamping plate, the fixed clamping plate is fixed on the base through a support, and the movable clamping plate is fixed on the telescopic rod.
Furthermore, the end face of the fixed splint is provided with a convex block, the end face of the movable splint is provided with a groove, and the dialysis bag is clamped tightly when the convex block is matched with the groove.
Further, a plurality of bar grooves matched with the magnetic stirrers are radially arranged on the flat plate along the air cylinder, the bottoms of the magnetic stirrers are connected with adjusting blocks which are arranged in the bar grooves in a sliding mode, the adjusting blocks which are symmetrically arranged are connected with bidirectional screws in a threaded mode, the middles of the bidirectional screws are rotatably connected with limiting blocks, and the limiting blocks are fixed on the flat plate.
Furthermore, one end of the bidirectional screw is connected with a dialysis motor, and the dialysis motor is fixed on the flat plate.
Further, dialysis cup circumference is equipped with a plurality of curved hot plates, and the hot plate is connected with the bracing piece, and the bracing piece bottom is connected with the T-shaped piece, and the T-shaped groove that matches with the T-shaped piece is seted up to the magnetic stirrers.
Furthermore, a fastening screw for fixing the T-shaped block is arranged on the T-shaped block.
The invention has the beneficial effects that:
1. utilize the holding head to dialyse the bag centre gripping, make the dialysis cup be located under the dialysis bag through removing magnetic stirrers, make the dialysis bag immerse the dislysate completely when the cylinder contracts, improve dialysis efficiency, through the cylinder rotation with go up and down for dialyse the bag immerse different dialysis cups one by one in, can realize automatic multistage dialysis, the practicality is strong.
2. Utilize the rotor stirring dislysate during the dialysis, improve the dialysis effect, through two-way screw rod drive regulating block for the magnetic stirrers of symmetry setting remove to centre or both ends simultaneously, improve the device precision.
3. The direction of the clamping cylinder can be controlled by the clamping motor, so that the dialysis bag can be clamped conveniently, and the relative position of the dialysis bag and the dialysis cup can be adjusted, and the dialysis bag is ensured to be completely immersed in the dialysate.
4. The telescopic link is elongated movable clamp plate and is removed to solid fixed splint, and lug and recess cooperation this moment, the increase is not hard up to the seal area in dialysis area, avoids appearing the centre gripping, causes the sample loss.
5. The heating plate can be used for heating dialysate, so that the dialysis efficiency is improved, and the heating plate can be applied to heating dialysis cups with different diameters by adjusting the position of the T-shaped block inserted into the T-shaped groove, so that the application range is expanded.
Drawings
Fig. 1 is a first structural diagram of the present invention.
FIG. 2 is a second schematic structural diagram of the present invention.
FIG. 3 is a schematic cross-sectional view of the present invention.
Fig. 4 is a schematic view of a portion C of fig. 2.
Fig. 5 is a schematic view of a partial structure a in fig. 1.
Fig. 6 is a schematic view of a portion B of fig. 1.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the following detailed description of the embodiments of the present invention is provided with reference to the accompanying drawings, but the described embodiments of the present invention are a part of the embodiments of the present invention, not all of the embodiments of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or orientations or positional relationships that the products of the present invention are usually placed in when used, and are only for convenience of describing the present invention and simplifying the description. The terms "first," "second," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance. The terms "parallel", "perpendicular", etc. do not require that the components be absolutely parallel or perpendicular, but may be slightly inclined.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; either directly or indirectly through intervening media, or through both elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
As shown in fig. 1 to 3, a dialysis apparatus includes a driving mechanism 1, a clamping mechanism 2, and a dialysis mechanism 3 disposed below the clamping mechanism 2.
Actuating mechanism 1 includes the cylinder 101 of vertical setting, and cylinder 101 can be followed cylinder 101 axis rotation, and cylinder 101 top symmetry is equipped with a plurality of horizontal poles 102, and horizontal pole 102 is fixed in cylinder 101 top through screw 106, and cylinder 101 bottom is rotated and is connected with dull and stereotyped 4, and cylinder 101 bottom circumference is equipped with annular rack 103, and annular rack 103 cooperates there is gear 104, and driving motor 105 is connected to gear 104, and driving motor 105 locates dull and stereotyped 4 below.
The clamping mechanism 2 is arranged at the end part of the cross rod 102 and comprises a clamping cylinder 201 capable of rotating on a vertical surface, and the top end of the clamping cylinder 201 is connected with a clamping head 202.
The dialysis mechanism 3 comprises a plurality of magnetic stirrers 301 arranged along the circumferential direction of the cylinder 101, the magnetic stirrers 301 can move along the radial direction of the cylinder 101, a dialysis cup 302 is arranged on the magnetic stirrers 301, and a rotor 303 is arranged in the dialysis cup 302.
Dull and stereotyped 4 has radially seted up a plurality of bar grooves 401 that match with magnetic stirrers 301 along cylinder 101, and magnetic stirrers 301 bottom is connected with the regulating block 304 that slides and locate bar groove 401, and the regulating block 304 threaded connection that the symmetry set up has two-way screw 305, and two-way screw 305 middle part rotates and is connected with stopper 306, and stopper 306 is fixed in dull and stereotyped 4, and two-way screw 305 one end is connected with dialysis motor 307, and dialysis motor 307 is fixed in dull and stereotyped 4.
During dialysis, the dialysis bag containing a sample is clamped by the clamping head 202, dialysate is filled into the dialysis cup 302, the clamping cylinder 201 rotates on a vertical surface, the dialysis cup 302 is positioned under the dialysis bag by moving the magnetic stirrer 301, and the dialysis bag is completely immersed into the dialysate when the cylinder 101 contracts; the magnetic stirrer 301 is started, and the rotor 303 is used for stirring the dialysate, so that the dialysis efficiency is improved; when multi-stage dialysis is carried out, a plurality of dialysis cups 302 can be arranged, and the dialysis bag can be gradually immersed into different dialysis cups 302 through rotation and lifting of the air cylinder 101; the rotation angle of the air cylinder 101 is controlled by a driving motor 105, and transmission is carried out by utilizing the matching of a gear 104 of an annular toothed bar 103 connected with the bottom of the air cylinder 101, so that automatic dialysis is realized; when the position of the magnetic stirrer 301 is adjusted, the dialysis motor 307 rotates the bidirectional screw 305 to drive the adjusting block 304, so that the symmetrically arranged magnetic stirrers 301 move towards the middle or two ends simultaneously, and the precision of the device is improved.
Further, as shown in fig. 4, the clamping cylinder 201 has a base 203 and an expansion rod 204, the bottom end of the base 203 is connected with a ring block 205, a driving block 206 is fitted in the ring block 205, the driving block 206 is connected with a clamping motor 207, and the clamping motor 207 is fixed on the cross bar 102.
The base 203 of the clamping cylinder 201 is connected with the clamping motor 207 through the matching of the annular block 205 and the driving block 206, the direction of the clamping cylinder 201 can be controlled through the clamping motor 207, the clamping of the dialysis bag is convenient, and the relative position of the dialysis bag and the dialysis cup 302 is adjusted, so that the dialysis bag is ensured to be completely immersed in the dialysate.
Further, as shown in fig. 5, the clamping head 202 has a fixed clamping plate 208 and a movable clamping plate 209, the fixed clamping plate 208 is fixed to the base 203 through a bracket 210, the movable clamping plate 209 is fixed to the telescopic rod 204, a protrusion 211 is disposed on an end surface of the fixed clamping plate 208, a groove 212 is disposed on an end surface of the movable clamping plate 209, and the protrusion 211 and the groove 212 cooperate to clamp the dialysis bag.
The switching of solid fixed splint 208 and movable clamp plate 209 is controlled through centre gripping cylinder 201, and movable clamp plate 209 removes to solid fixed splint 208 when telescopic link 204 extension, and lug 211 and recess 212 cooperation this moment, the increase is not hard up to the sealed area of dialysis area, avoids appearing the centre gripping, causes the sample loss.
Further, as shown in fig. 6, a plurality of arc-shaped heating plates 5 are arranged on the dialysis cup 302 in the circumferential direction, the heating plates 5 are connected with a support rod 501, a T-shaped block 502 is connected to the bottom end of the support rod 501, a T-shaped groove 308 matched with the T-shaped block 502 is formed in the magnetic stirrer 301, and a fastening screw 503 for fixing the T-shaped block 502 is arranged on the T-shaped block 502.
The outer wall of dialysis cup 302 is located to hot plate 5, can heat the dislysate, improves the dialysis efficiency, inserts the position of T-shaped groove 308 through adjusting T-shaped block 502, can be applied to the heating of different diameter dialysis cups 302, enlarges the range of application, accessible fastening screw 503 is fixed when T-shaped block 502 position control finishes, prevents that hot plate 5 and dialysis cup 302 break away from, influences the heating effect.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and it is apparent that those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.

Claims (10)

1. A dialysis device, comprising:
the driving mechanism (1) comprises a vertically arranged air cylinder (101), the air cylinder (101) can rotate along the central axis of the air cylinder (101), and a plurality of cross rods (102) are symmetrically arranged at the top of the air cylinder (101);
the clamping mechanism (2) is arranged at the end part of the cross rod (102) and comprises a clamping cylinder (201) capable of rotating on a vertical surface, and the top end of the clamping cylinder (201) is connected with a clamping head (202);
dialysis mechanism (3), locate fixture (2) below, including a plurality of magnetic stirrers (301) that set up along cylinder (101) circumference, magnetic stirrers (301) can be followed cylinder (101) radial movement, are equipped with on magnetic stirrers (301) and dialyse cup (302), are equipped with rotor (303) in dialysing cup (302).
2. A dialysis device according to claim 1, wherein: the bottom end of the air cylinder (101) is rotatably connected with the flat plate (4), an annular toothed rod (103) is arranged on the bottom of the air cylinder (101) in the circumferential direction, the annular toothed rod (103) is matched with a gear (104), the gear (104) is connected with a driving motor (105), and the driving motor (105) is arranged below the flat plate (4).
3. A dialysis device according to claim 1, wherein: the cross rod (102) is fixed on the top of the air cylinder (101) through a screw (106).
4. A dialysis device according to claim 1, wherein: the clamping cylinder (201) is provided with a base (203) and an expansion rod (204), the bottom end of the base (203) is connected with an annular block (205), a driving block (206) is matched in the annular block (205), the driving block (206) is connected with a clamping motor (207), and the clamping motor (207) is fixed on the cross rod (102).
5. A dialysis device according to claim 4, wherein: the clamping head (202) is provided with a fixed clamping plate (208) and a movable clamping plate (209), the fixed clamping plate (208) is fixed on the base (203) through a bracket (210), and the movable clamping plate (209) is fixed on the telescopic rod (204).
6. A dialysis device according to claim 5, wherein: the end face of the fixed splint (208) is provided with a convex block (211), the end face of the movable splint (209) is provided with a groove (212), and the dialysis bag is clamped when the convex block (211) is matched with the groove (212).
7. A dialysis device according to claim 2, wherein: dull and stereotyped (4) are radially seted up a plurality of bar grooves (401) that match with magnetic stirrers (301) along cylinder (101), and magnetic stirrers (301) bottom is connected with and slides and locates regulating block (304) of bar groove (401), and regulating block (304) threaded connection that the symmetry set up has two-way screw rod (305), and two-way screw rod (305) middle part rotates and is connected with stopper (306), and stopper (306) are fixed in dull and stereotyped (4).
8. A dialysis device according to claim 7, wherein: one end of the bidirectional screw (305) is connected with a dialysis motor (307), and the dialysis motor (307) is fixed on the flat plate (4).
9. A dialysis device according to claim 1, wherein: dialysis cup (302) circumference is equipped with a plurality of curved hot plates (5), and hot plate (5) are connected with bracing piece (501), and bracing piece (501) bottom is connected with T-shaped piece (502), and magnetic stirrers (301) are seted up T-shaped groove (308) that match with T-shaped piece (502).
10. A dialysis device according to claim 9, wherein: the T-shaped block (502) is provided with a fastening screw (503) for fixing the T-shaped block (502).
CN202010504558.9A 2020-06-05 2020-06-05 Dialysis device Pending CN111659257A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010504558.9A CN111659257A (en) 2020-06-05 2020-06-05 Dialysis device

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Application Number Priority Date Filing Date Title
CN202010504558.9A CN111659257A (en) 2020-06-05 2020-06-05 Dialysis device

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CN111659257A true CN111659257A (en) 2020-09-15

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CN (1) CN111659257A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112480251A (en) * 2020-11-30 2021-03-12 江西中洪博元生物技术有限公司 Intelligent high-specificity combined VEGFA multi-antibody screening and purifying device

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Publication number Priority date Publication date Assignee Title
DE2659690A1 (en) * 1976-12-31 1978-07-20 Kernforschungsz Karlsruhe Multistage dialysis appts. with valves between cells - to permit various permutations giving constant sepn. level
CN101157009A (en) * 2007-07-26 2008-04-09 浙江大学 A non-oxygen dialysis apparatus
CN206366399U (en) * 2016-12-19 2017-08-01 郑州伊美诺生物技术有限公司 dynamic dialysis bag pressing device
CN107857794A (en) * 2017-12-20 2018-03-30 天康生物股份有限公司 Protein dialysis apparatus and system
CN207899486U (en) * 2018-01-28 2018-09-25 乐山职业技术学院 Iron stand is operated for deionized water dialysis
CN208018432U (en) * 2018-02-08 2018-10-30 青岛汉德森生物科技有限公司 Experiment dialysis machine
CN208715850U (en) * 2018-09-11 2019-04-09 新乡医学院 A kind of bag filter clips
CN209148404U (en) * 2018-12-11 2019-07-23 杭州华葵金配生物科技有限公司 A kind of Protein Detection purification devices crude separation equipment
CN209679880U (en) * 2018-11-28 2019-11-26 南通科技职业学院 A kind of dialysis apparatus improving dialysis speed

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2659690A1 (en) * 1976-12-31 1978-07-20 Kernforschungsz Karlsruhe Multistage dialysis appts. with valves between cells - to permit various permutations giving constant sepn. level
CN101157009A (en) * 2007-07-26 2008-04-09 浙江大学 A non-oxygen dialysis apparatus
CN206366399U (en) * 2016-12-19 2017-08-01 郑州伊美诺生物技术有限公司 dynamic dialysis bag pressing device
CN107857794A (en) * 2017-12-20 2018-03-30 天康生物股份有限公司 Protein dialysis apparatus and system
CN207899486U (en) * 2018-01-28 2018-09-25 乐山职业技术学院 Iron stand is operated for deionized water dialysis
CN208018432U (en) * 2018-02-08 2018-10-30 青岛汉德森生物科技有限公司 Experiment dialysis machine
CN208715850U (en) * 2018-09-11 2019-04-09 新乡医学院 A kind of bag filter clips
CN209679880U (en) * 2018-11-28 2019-11-26 南通科技职业学院 A kind of dialysis apparatus improving dialysis speed
CN209148404U (en) * 2018-12-11 2019-07-23 杭州华葵金配生物科技有限公司 A kind of Protein Detection purification devices crude separation equipment

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112480251A (en) * 2020-11-30 2021-03-12 江西中洪博元生物技术有限公司 Intelligent high-specificity combined VEGFA multi-antibody screening and purifying device
CN112480251B (en) * 2020-11-30 2023-07-11 江西中洪博元生物技术有限公司 Intelligent high-specificity combined VEGFA multi-antibody screening and purifying device

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