CN111632091A - 一种治疗外伤的组合物及其制备方法 - Google Patents
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Abstract
本发明公开了一种治疗外伤的组合物及其制备方法。属于外伤治疗技术领域。该组合物包括如下质量份数的组分：石灰5‑15份、红粉2‑6份、轻粉2‑6份、冰片3‑7份、白芷1‑4份、黄莲2‑5份和黄柏2‑5份。该组合物经过阴干、粉碎、过筛、称量、混合、包装制备而成。与现有技术相比，本发明取得的有益效果为：(1)具有快速止血、消炎、止痛、生肌的作用；(2)无副作用，痊愈后疤痕微小；(3)操作简单，无需清洗伤口。
Description
技术领域
本发明涉及外伤治疗技术领域，更具体的说是涉及一种治疗外伤的组合物及其制备方法。
背景技术
外伤的种类很多，通常有刀伤、烫伤、擦伤、烧伤、跌打损伤等，会引起局部皮肤的出血、红肿、疼痛、出现水泡等。若皮肤出现破损，各种病原微生物就会乘虚而入，造成创面感染，若治疗不及时还会进一步引发皮肤溃烂。这些病症会严重影响病人的生活、工作和学习，严重时会造成合并感染、休克等全身变化。因此，对于外伤创口一定要进行严格认真的处理治疗。
在外伤的治疗过程中，清洗创口会给患者带来痛苦，且清洗时一般使用抗生素消炎，对病人有一定的副作用；生肌速度慢，止血消炎效果不佳；伤口留疤。
综上，如何提供一种无需清理创口、生肌速度快、痊愈后疤痕微小的治疗外伤的组合物是本领域技术人员亟需解决的问题。
发明内容
有鉴于此，本发明提供了一种治疗外伤的组合物及其制备方法。
为了实现上述目的，本发明采用如下技术方案：
一种治疗外伤的组合物，包括如下质量份数的组分：石灰5-15份、红粉2-6份、轻粉2-6份、冰片3-7份、白芷1-4份、黄莲2-5份和黄柏2-5份。
石灰味辛、苦、涩，性温。归肝、脾经。具有解毒蚀腐，敛疮止血，杀虫止痒的功效。用于痈疽疔疮，丹毒，瘰疬痰核，赘疣，外伤出血，水火烫伤，下肢溃疡，久痢脱肛，疥癣，湿疹，痱子。
红粉味辛，性热。具有拔毒提脓，祛腐生肌，燥湿杀虫的功效。主治痈疽疔疮，梅毒下疳，瘿瘤瘰疬，一切恶疮肉暗紫黑，疮口坚硬，腐肉不去，窦道瘘管，脓水淋漓，久不收口，以及湿疮，疥癣。
轻粉味辛，性寒。归大肠、小肠经。轻粉具有抗菌、泻下、利尿等作用。外用可以治疗疥疮、臁疮、顽癣、梅毒、湿疹、疮疡；内服可以治疗水肿臌胀、痰涎积滞、二便不利等。
冰片辛、苦，微寒。归心、脾、肺经。清香宣散，具有开窍醒神，清热散毒，明目退翳的功效。主治热病高热神昏，中风痰厥惊痫，暑湿蒙蔽清窍，喉痹耳聋，口疮齿肿，疮痈疳痔，目赤肿痛，翳膜遮睛。
白芷辛，温；归肺、胃、大肠经。具有解表散寒，祛风止痛，通鼻窍，燥湿止带，消肿排脓，祛风止痒功效。主治风寒感冒，头痛，牙痛，风湿痹痛，鼻渊，带下证，疮痈肿毒，皮肤风湿瘙痒。
黄莲苦，寒。归心、脾、胃、肝、胆、大肠经。有清热燥湿，泻火解毒的功效。用于湿热痞满，呕吐吞酸，泻痢，黄疸，高热神昏，心火亢盛，心烦不寐，血热吐衄，目赤，牙痛，消渴，痈肿疔疮；外治湿疹，湿疮，耳道流脓。
黄柏苦，寒；归肾、膀胱、大肠经。具有清热燥湿，泻火解毒，除骨蒸的功效。主治湿热带下，热淋涩痛，湿热泻痢，黄疸，湿热脚气，瘘证，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹瘙痒。
在创伤修复中肉芽组织具有重要作用。肉芽组织的主要成分为新生毛细血管和成纤维细胞，凡是能初级毛细血管的增生和成纤维细胞增殖就有利于创伤愈合。本发明组合物的生肌作用体现在：(1)改善创面的血液循环，加速创面的新陈代谢。伤口新生的毛细血管数目增多，管腔扩大，血运旺盛，形成小动脉和小静脉，这些再生血管不仅为伤口修复提供了丰富的氧和必需的营养物质，也为伤口肉芽组织迅速生长，成纤维细胞增殖分化提供了必要条件。(2)成纤维细胞含量丰富，功能活跃。
优选的，一种治疗外伤的组合物，包括如下质量份数的组分：石灰10份、红粉3份、轻粉3份、冰片4份、白芷2份、黄莲3份和黄柏3份。
一种治疗外伤的组合物的制备方法，包括如下步骤：
(1)石灰经阴干、碾压、过筛、称量，得预混料a；
(2)红粉、轻粉、冰片、白芷、黄莲和黄柏经阴干、粉碎、过筛、称量后混合，得预混料b；
(3)将预混料a与预混料b混合均匀后包装即得成品。
优选的，步骤(1)与步骤(2)操作时保持温度为25-28℃。
优选的，步骤(1)与步骤(2)均过200目筛。
优选的，步骤(3)混合时搅拌转速15-20r/min，搅拌时间3-7min。
使用方法为：将本发明制剂撒在创面上，每天使用1-2次，7-15天创面即可痊愈。
经由上述的技术方案可知，与现有技术相比，本发明取得的有益效果为：(1)具有快速止血、消炎、止痛、生肌的作用；(2)无副作用，痊愈后疤痕微小；(3)操作简单，无需清洗伤口。
具体实施方式
下面将结合对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
本发明所需药剂为常规实验药剂，采购自市售渠道；未提及的实验方法为常规实验方法，在此不再一一赘述。
实施例1
(1)石灰经阴干、碾压、过200目筛，称量5g，得预混料a，操作时保持温度为25-28℃；
(2)红粉、轻粉、冰片、白芷、黄莲和黄柏经阴干、粉碎、过200目筛，称量红粉2g、轻粉2g、冰片3g、白芷1g、黄莲2g、黄柏2g后混合，得预混料b，操作时保持温度为25-28℃；
(3)将预混料a与预混料b混合均匀，搅拌转速15r/min，搅拌时间3min，包装即得成品。
实施例2
(1)石灰经阴干、碾压、过200目筛，称量15g，得预混料a，操作时保持温度为25-28℃；
(2)红粉、轻粉、冰片、白芷、黄莲和黄柏经阴干、粉碎、过200目筛，称量红粉6g、轻粉6g、冰片7g、白芷4g、黄莲5g、黄柏5g后混合，得预混料b，操作时保持温度为25-28℃；
(3)将预混料a与预混料b混合均匀，搅拌转速20r/min，搅拌时间7min，包装即得成品。
实施例3
(1)石灰经阴干、碾压、过200目筛，称量10g，得预混料a，操作时保持温度为25-28℃；
(2)红粉、轻粉、冰片、白芷、黄莲和黄柏经阴干、粉碎、过200目筛，称量红粉3g、轻粉3g、冰片4g、白芷2g、黄莲3g、黄柏3g后混合，得预混料b，操作时保持温度为25-28℃；
(3)将预混料a与预混料b混合均匀，搅拌转速17r/min，搅拌时间5min，包装即得成品。
实验1抗炎镇痛活性实验
(1)实验分组：
实验组分别施用本发明实施例1-3制备的组合物；对照组施用云南白药；空白组施用蒸馏水。
(2)实验方法：
采用100只昆明小鼠雌雄各半，随机分为5组，每组20只小鼠。各组小鼠腹部敷药，每天3次，连续给药7天，于第7天最后一次给药30min后，每只小鼠右耳均匀涂抹30μl二甲苯，2小时后处死小鼠，剪下小鼠双耳，用8mm打孔器取双耳同样面积大小组织称重，计算左右耳两侧面积之并计算肿胀率，结果见表1。
表1抗炎镇痛实验结果
| 组别 | 肿胀度 | 肿胀率 |
| 实施例1 | 7.69 | 64.8％ |
| 实施例2 | 7.43 | 63.2％ |
| 实施例3 | 7.87 | 65.4％ |
| 对照组 | 10.32 | 75.4％ |
| 空白组 | 13.06 | 87.6％ |
病例1
马某，女，35岁，右臂被玻璃刮开十多公分的裂口，鲜血直流，简单纱布包扎后到医院治疗，打破伤风针、抗生素输液、伤口消毒清洗后湿敷复方黄柏浓缩液，如此治疗2周，仍有许多脓水不断渗出，后停止其他药物治疗，采用实施例1制备的组合物敷在伤口患处，肿胀疼痛明显消退，一周后伤口患处无渗出液、无脓液分泌，并有肉芽长出，10天后伤口全部结痂，停止用药，结痂自行脱落，原创面处无疤痕，颜色与周围正常皮肤无异。
病例2
杨某，女，48岁，患妇因切菜，不慎切去左手拇指上的一块皮肉，失于缝合，经市医院普外处理，后化脓感染，患者疼痛难眠，局部红肿发热，色紫暗，流脓血水。使用实施例2制备的组合物，3天后疼痛减轻，局部已不发热，观其伤面，红肿消退，脓血水已减少，色已红润，继续使用2天，新生组织长出。
病例3
张某，男，56岁，患者因不慎跌倒，撞伤右小腿部，普外科处理，后感染，失治月余，留有拇指大小一块，经久难愈，视其局部红肿流血水，色紫暗，经多方求治无效。使用本发明实施例3制备的组合物，3天后痊愈，且疤痕微小。
病例4
金某，男，12岁，腿部被犬咬伤，注射疫苗后，伤口感染化脓。采用实施例2制备的组合物外敷于患处，每天换药一次，第3天换药时，肉眼可见新肉生长，7天后伤口长平，敛口愈合，无疤痕。
病例5
齐某，女，18岁，热水将右腿烫伤三分之一，有的地方脱了皮，起了很多大水泡，又肿又辣又刺痛，活动、走路都十分艰难。购药房的烫伤膏自疗，伤口脓水渗出液不断分泌，疼痛不止。使用实施例1制备的组合物敷于患处，第三天患处渗出液脓液明显减少，疼痛减轻，第五天伤口开始收敛干爽，无分泌物，一周后伤口患处结痂。
本说明书中各个实施例采用递进的方式描述，每个实施例重点说明的都是与其他实施例的不同之处，各个实施例之间相同相似部分互相参见即可。
对所公开的实施例的上述说明，使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的，本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下，在其它实施例中实现。因此，本发明将不会被限制于本文所示的这些实施例，而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。
Claims (6)
1.一种治疗外伤的组合物，其特征在于，包括如下质量份数的组分：石灰5-15份、红粉2-6份、轻粉2-6份、冰片3-7份、自芷1-4份、黄莲2-5份和黄柏2-5份。
2.如权利要求1所述的一种治疗外伤的组合物，其特征在于，包括如下质量份数的组分：石灰10份、红粉3份、轻粉3份、冰片4份、白芷2份、黄莲3份和黄柏3份。
3.如权利要求1-2任一所述的一种治疗外伤的组合物的制备方法，其特征在于，包括如下步骤：
(1)石灰经阴干、碾压、过筛、称量，得预混料a；
(2)红粉、轻粉、冰片、白芷、黄莲和黄柏经阴干、粉碎、过筛、称量后混合，得预混料b；
(3)将预混料a与预混料b混合均匀后包装即得成品。
4.如权利要求3所述的一种治疗外伤的组合物的制备方法，其特征在于，步骤(1)与步骤(2)操作时保持温度为25-28℃。
5.如权利要求3所述的一种治疗外伤的组合物的制备方法，其特征在于，步骤(1)与步骤(2)均过200目筛。
6.如权利要求3所述的一种治疗外伤的组合物的制备方法，其特征在于，步骤(3)混合时搅拌转速15-20r/min，搅拌时间3-7min。
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| CN108210548A (zh) * | 2018-03-27 | 2018-06-29 | 王向阳 | 用于外伤创面的中药药膏及其制备方法 |
| CN109718333A (zh) * | 2019-03-20 | 2019-05-07 | 卢作温 | 一种促进外伤愈合的中药外敷制剂 |
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| CN108210548A (zh) * | 2018-03-27 | 2018-06-29 | 王向阳 | 用于外伤创面的中药药膏及其制备方法 |
| CN109718333A (zh) * | 2019-03-20 | 2019-05-07 | 卢作温 | 一种促进外伤愈合的中药外敷制剂 |
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