CN111388604A - 一种治疗偏头痛的中药组合物及其制备方法 - Google Patents
一种治疗偏头痛的中药组合物及其制备方法 Download PDFInfo
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- CN111388604A CN111388604A CN202010449287.1A CN202010449287A CN111388604A CN 111388604 A CN111388604 A CN 111388604A CN 202010449287 A CN202010449287 A CN 202010449287A CN 111388604 A CN111388604 A CN 111388604A
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Abstract
本发明公开了一种治疗偏头痛的中药组合物及其制备方法,属于中医药技术领域。该中药组合物的原料为:川芎12‑20份、当归15‑25份、延胡索15‑25份、白芍12‑20份、丹参12‑20份、天麻8‑15份、桃仁8‑15份、红花6‑12份、附子2‑5份、羌活8‑15份、防风8‑15份、细辛5‑10份、桑叶8‑15份、甘菊花8‑15份、沙苑子12‑20份、柴胡8‑15份、苍术8‑15份、甘草8‑15份。制备方法为:对白芍、天麻、细辛和柴胡用乙醇溶液提取并分离出醇提浸膏和药渣;对药渣及其它原料用水提取并分离出水提浸膏;将醇提浸膏和水提浸膏合并,干燥,即得。该中药组合物具有疏风活血、平肝潜阳、通络止痛及温补肝肾的功效,药效成分明确,化学毒副作用小,可有效地缓解风阳挟瘀证,临床治疗偏头痛疗效好。
Description
技术领域
本发明属于中医药技术领域,尤其涉及一种治疗偏头痛的中药组合物及其制备方法。
背景技术
偏头痛属于祖国医学“脑风”“头痛”范畴,是一类反复发作的搏动性头痛,多为一侧或两侧颞部发作,发作时常伴恶心、呕吐等。偏头痛是由多种因素共同引发的疾病,患病率呈现上升趋势。偏头痛的发作与风邪、肝经风阳上扰及瘀血密切相关。肝阳上亢,阳亢化风,肝风内动,风阳上扰清窍,导致头痛发作,可见肝阳上亢、肝风内动是偏头痛发生的基础病机。临床上偏头痛的单一证型少见,而常见血虛阳亢挟瘀、风阳挟瘀证等复合证型。其中,风阳挟瘀型偏头痛是肝阳上亢、阳亢化风,上扰清阳,久而瘀阻脑窍所致,缓解复发是其主要的临床特征。
目前用于治疗偏头痛的中药很多,但治疗的证候及疗效不一。公告号为CN104491759B的专利公开了一种治疗偏头痛的中药组合物,组成处方为:柴胡7-17份、延胡索13-23份、川芎7-17份、桃仁7-17份、红花4-14份、当归10-20份、白芍10-20份、熟地黄10-20份、香附7-17份、丹参13-23份、桂枝7-17份、天麻10-20份、栀子5-15份、黄芩7-17份、石菖蒲13-23份、吴茱萸3-9份、藁本7-17份、郁金7-17份、白芷4-14份、川牛膝10-20份、菊花4-14份、炙甘草3-9份,具有祛风止痛、活血通经、散瘀定痛的功效。该药从瘀论治,重在活血通络、祛瘀止痛,治疗原发性偏头痛有较好的疗效。但风阳挟瘀证发病过程复杂,迁延难愈,且有缓解复发的特点,同时伴脏腑功能失调的证候,因而该中药治疗风阳挟瘀证疗效局限大。另外,该中药处方所用药味种类繁多,药效成分宽泛不明确,不利于较长病程的临床治疗。
发明内容
本发明的目的是:提供一种治疗偏头痛的中药组合物,通过较少药味的合理配伍精简了处方,使组方紧凑且药效成分确切,用于治疗风阳挟瘀型偏头痛有较好的疗效。
为了实现上述目的,本发明采用的技术方案是:
本发明提供了一种治疗偏头痛的中药组合物,以重量份计,由以下原料制成:川芎12-20份、当归15-25份、延胡索15-25份、白芍12-20份、丹参12-20份、天麻8-15份、桃仁8-15份、红花6-12份、附子2-5份、羌活8-15份、防风8-15份、细辛5-10份、桑叶8-15份、甘菊花8-15份、沙苑子12-20份、柴胡8-15份、苍术8-15份、甘草8-15份。
作为优选,以重量份计,所述中药组合物由以下原料制成:
川芎15-20份、当归20-25份、延胡索20-25份、白芍15-20份、丹参15-20份、天麻10-15份、桃仁10-15份、红花8-12份、附子3-5份、羌活10-15份、防风10-15份、细辛5-7份、桑叶10-15份、甘菊花10-15份、沙苑子15-20份、柴胡10-15份、苍术10-15份、甘草10-15份。
作为优选,以重量份计,所述中药组合物由以下原料制成:
川芎17份、当归22份、延胡索22份、白芍17份、丹参17份、天麻12份、桃仁12份、红花10份、附子4份、羌活12份、防风12份、细辛6份、桑叶12份、甘菊花12份、沙苑子17份、柴胡12份、苍术12份、甘草12份。
本发明还提供了上述治疗偏头痛的中药组合物的制备方法,步骤如下:
取白芍、天麻、细辛和柴胡,加乙醇溶液作提取溶剂,回流提取,滤过,合并提取液并浓缩,得到醇提浸膏和药渣;
将沙苑子、川芎、当归、延胡索、丹参、桃仁、红花、附子、羌活、防风、桑叶、甘菊花、苍术和甘草投至所述药渣中,加水作提取溶剂,煎煮提取,滤过,合并提取液并浓缩,得到水提浸膏;
将醇提浸膏和水提浸膏合并,干燥,得到中药组合物。
作为优选,所述乙醇溶液的体积百分含量为60-75%,乙醇溶液的加入量为白芍、天麻、细辛和柴胡重量之和的5-8倍,回流提取的次数为2-3次,每次回流提取的时间为0.5-2h。
作为优选,所述水的用量为沙苑子、川芎、当归、延胡索、丹参、桃仁、红花、附子、羌活、防风、桑叶、甘菊花、苍术、甘草和所述药渣的总体积的8-10倍,每次煎煮提取的时间为0.5-1h。
作为优选,所述醇提浸膏和水提浸膏浓缩至相对密度1.10-1.20(室温)。
本发明还提供了所述中药组合物在制备治疗偏头痛药物中的应用。
本发明还提供了一种治疗偏头痛的中药制剂,是由所述中药组合物和药学上可接受的辅料制备成。
作为优选,其剂型包括胶囊剂、片剂、颗粒剂、滴丸剂或口服液。
与现有技术相比,本发明的有益效果在于:
本发明的中药组合物配伍合理,组方紧凑,减少了药味种类;该中药组合物具有疏风活血、平肝潜阳、通络止痛及温补肝肾的功效,药效成分明确,化学毒副作用小,可安全有效地缓解风阳挟瘀证,临床治疗偏头痛疗效好;本发明的制备工艺简便,不仅能提高药效成分含量,还能降低药物毒性,显著提高了产品的药效。
具体实施方式
为了便于理解本发明,下面结合实施例对本发明优选实施方案进行描述。应当理解,以下描述只是为了说明本发明的特征和优点,而不是对本发明权利要求的限制。
本发明所提供的治疗偏头痛的中药组合物,由以下重量份的原料制成:
川芎12-20份、当归15-25份、延胡索15-25份、白芍12-20份、丹参12-20份、天麻8-15份、桃仁8-15份、红花6-12份、附子2-5份、羌活8-15份、防风8-15份、细辛5-10份、桑叶8-15份、甘菊花8-15份、沙苑子12-20份、柴胡8-15份、苍术8-15份、甘草8-15份。
本发明对所有原料的来源并没有特殊的限制,为市售即可。
所述川芎的优选用量为15-20份,更优选用量为17份。川芎,性温,味辛;活血行气,祛风止痛,扩张血管并降低脑血管阻力及总外周阻力,增加脑血流量,治一切风,一切气,一切劳损,一切血,补五劳,壮筋骨,调众脉,破癥结宿血,养新血。
所述当归的优选用量为20-25份,更优选用量为22份。当归,性温,味甘、辛;补血活血,调经止痛,促进肝功能并减小脑动脉阻力,增加脑血流量,治一切风,一切血,补一切劳,破恶血,养新血。
所述延胡索的优选用量为20-25份,更优选为22份。延胡索,性温,味辛、苦;活血,行气,止痛,除风,扩张血管并降低脑血管阻力,增加脑血流量。
所述白芍的优选用量为15-20份,更优选为17份。白芍,性微寒,味苦、酸;养血调经,敛阴止汗,柔肝止痛,平抑肝阳,扩张血管并增加脑血流量。
所述丹参的优选用量为15-20份,更优选为17份。丹参,性微寒,味苦;为心、脾、肝、肾血分之药,有活血祛瘀,通经止痛,凉血消痈,增加脑部组织微循环的血液灌流的作用。
所述天麻的优选用量为10-15份,更优选为12份。天麻,性平,味甘;为肝经气分之药,息风止痉,平抑肝阳,祛风通络。
所述桃仁的优选用量为10-15份,更优选为12份。桃仁,性平,味苦、甘;活血祛瘀,主攻瘀血而为肝药,味甘以缓肝散血。
所述红花的优选用量为8-12份,更优选为10份。红花,性温,味辛;活血通经,散瘀止痛,疏肝气,扩张脑血管并增加脑血流量。
所述附子的优选用量为3-5份,更优选为4份。附子,性大热,味辛、甘;回阳救逆,补火助阳,散寒止痛,扩张血管并增加脑血流量,其为命门主药,能入窟穴而招之,引火归元,则浮游之火自熄矣,可制约肝阳上亢。
所述羌活的优选用量为10-15份,更优选为12份。羌活,性温,味辛、苦;解表散寒,祛风除湿,止痛,可泻肝气,搜肝风。
所述防风的优选用量为10-15份,更优选为12份。防风,性微温,味甘、辛;为风病之主药,祛风解表,胜湿止痛,可治肝阳之动风。
所述细辛的优选用量为5-7份,更优选为6份。细辛,性温,味辛;解表散寒,祛风止痛,通窍,温肺,其善开结气,宣泄郁滞,而能上达巅顶,旁达百骸,无微不至。
所述桑叶的优选用量为10-15份,更优选为12份。桑叶,性寒,味甘、苦,疏散风热,清肺润燥,清肝明目,息内风而除头痛。
所述甘菊花的优选用量为10-15份,更优选为12份。甘菊花,性微寒,味甘、苦;散风清热,平肝明目,清热解毒,为祛风要药。
所述沙苑子的优选用量为15-20份,更优选为17份。性温,味甘;补肾助阳,养肝明目。
所述柴胡的优选用量为10-15份,更优选为12份。柴胡,性微寒,味辛、苦;疏散退热,疏肝解郁,升举阳气。
所述苍术的优选用量为10-15份,更优选为12份。苍术,性温,味辛、苦;燥湿健脾,祛风散寒。
所述甘草的优选用量为10-15份,更优选为12份。甘草,性平,味甘;补脾益气,清热解毒,缓急止痛,调和诸药。
风阳挟瘀型偏头痛是外感风邪、瘀血阻络所致。方中川芎味薄气雄,性最疏通,能升能散,上至巅顶,旁达四肢,下行血海,走而不守,有活血行气、祛风止痛之功效;当归,味甘而重,专能补血,气轻而辛,又能行血,补中有动,行中有补,是血中之圣药,有养血、活血之功效;延胡索既能入“血分”而活血祛瘀,又能入“气分”而行气散滞,故能行血中气滞,气中血滞,是活血、行气、止痛要药,川芎、当归和延胡索共奏活血行气,祛风止痛之功效,共为君药。白芍养血柔肝、补血调经,敛阴止汗、缓急止痛;丹参祛瘀止痛、活血通经,其二者配合可“上行头目,下行血海”,“气行则血行”,故可辅川芎、当归和延胡索而增强活血祛瘀、祛风止痛的作用;天麻息风止痉、平肝潜阳、祛风止痛;桃仁与红花活血通络止痛;附子,为命门主药,能入窟穴而招之,引火归元,则浮游之火自熄,可制约肝阳上亢,以上六者共为臣药。防风与细辛祛风止痛、散寒除湿;桑叶与甘菊花疏散风热、平抑肝阳;沙苑子补益肝肾、平衡肝肾阴阳;柴胡擅治少阳头痛;苍术擅治太阴头痛;同时防风解附子之毒并引苍术上达颠顶,上七者共为佐药。羌活祛风除湿、解表散寒、舒筋活络,引诸药达上肢,甘草引药归经、调和诸药,此二者共为使药。上述诸药合用,君臣协力,佐使共辅,标本兼顾,具有疏风活血、平肝潜阳、通络止痛之功效,能有效治疗风阳挟瘀型偏头痛。
在本发明的一些优选实施方案中,所述的治疗偏头痛的中药组合物由以下原料药制成:川芎12份、当归15份、延胡索15份、白芍12份、丹参12份、天麻8份、桃仁8份、红花6份、附子2份、羌活8份、防风8份、细辛5份、桑叶8份、甘菊花8份、沙苑子12份、柴胡8份、苍术8份、甘草8份。
在本发明的一些优选实施方案中,所述的治疗偏头痛的中药组合物由以下原料药制成:川芎15份、当归20份、延胡索20份、白芍15份、丹参15份、天麻10份、桃仁10份、红花8份、附子3份、羌活10份、防风10份、细辛5份、桑叶10份、甘菊花10份、沙苑子15份、柴胡10份、苍术10份、甘草10份。
在本发明的一些优选实施方案中,所述的治疗偏头痛的中药组合物由以下原料药制成:川芎17份、当归22份、延胡索22份、白芍17份、丹参17份、天麻12份、桃仁12份、红花10份、附子4份、羌活12份、防风12份、细辛6份、桑叶12份、甘菊花12份、沙苑子17份、柴胡12份、苍术12份、甘草12份。
在本发明的一些优选实施方案中,所述的治疗偏头痛的中药组合物由以下原料药制成:川芎20份、当归25份、延胡索25份、白芍20份、丹参20份、天麻15份、桃仁15份、红花12份、附子5份、羌活15份、防风15份、细辛7份、桑叶15份、甘菊花15份、沙苑子20份、柴胡15份、苍术15份、甘草15份。
本发明还提供了上述治疗偏头痛的中药组合物的制备方法,包括步骤:
取白芍、天麻、细辛和柴胡,加乙醇溶液作提取溶剂,回流提取,滤过,合并提取液并浓缩,得到醇提浸膏和药渣;
将沙苑子、川芎、当归、延胡索、丹参、桃仁、红花、附子、羌活、防风、桑叶、甘菊花、苍术和甘草投至所述药渣中,加水作提取溶剂,煎煮提取,滤过,合并提取液并浓缩,得到水提浸膏;
将醇提浸膏和水提浸膏合并,干燥,得到中药组合物。
在本发明的优选实施方案中,所述乙醇溶液的体积百分含量为60-75%,乙醇溶液的加入量为白芍、天麻、细辛和柴胡重量之和的5-8倍,回流提取的次数为2-3次,每次回流提取的时间为0.5-2h。
在本发明的优选实施方案中,所述水的用量为沙苑子、川芎、当归、延胡索、丹参、桃仁、红花、附子、羌活、防风、桑叶、甘菊花、苍术、甘草和所述药渣的总体积的8-10倍,每次煎煮提取的时间为0.5-1h。
在本发明的优选实施方案中,所述醇提浸膏和水提浸膏浓缩至相对密度1.10-1.20(室温)。
本发明还提供了所述中药组合物在制备治疗偏头痛药物中的应用。
本发明还提供了一种治疗偏头痛的中药制剂,由所述中药组合物和药学上可接受的辅料。
在本发明的优选实施方案中,所述中药制剂的剂型为胶囊剂、片剂、颗粒剂、滴丸剂或口服液。
为进一步说明本发明,以下结合实施例进行详细阐述。
实施例1
本实施例提供了一种治疗偏头痛的中药组合物的制备
取白芍12g、天麻8g、细辛5g和柴胡8g,加其重量之和5-8倍的体积百分含量为60-75%的乙醇溶液作提取溶剂,回流提取2次,每次1.5h,滤过,合并两次提取液并浓缩至相对密度1.10-1.20(室温),得到醇提浸膏和药渣;
将沙苑子12g、川芎12g、当归15g、延胡索15g、丹参12g、桃仁8g、红花6g、附子2g、羌活8g、防风8g、桑叶8g、甘菊花8g、苍术8g和甘草8g投至所述药渣中,加所述药渣和沙苑子、川芎等药材的总体积的8-10倍的水作提取溶剂,煎煮提取2次,每次1.5h,滤过,合并提取液并浓缩至相对密度1.10-1.20(室温),得到水提浸膏;
将醇提浸膏和水提浸膏合并,真空干燥,即得。
实施例2
本实施例提供了一种治疗偏头痛的中药组合物的制备
取白芍15g、天麻10g、细辛5g和柴胡10g,加其重量之和5-8倍的体积百分含量为60-75%的乙醇溶液作提取溶剂,回流提取2次,每次1.5h,滤过,合并两次提取液并浓缩至相对密度1.10-1.20(室温),得到醇提浸膏和药渣;
将沙苑子15g、川芎15g、当归20g、延胡索20g、丹参15g、桃仁10g、红花8g、附子3g、羌活10g、防风10g、桑叶10g、甘菊花10g、苍术10g和甘草10g投至所述药渣中,加所述药渣和沙苑子、川芎等药材的总体积的8-10倍的水作提取溶剂,煎煮提取2次,每次1.5h,滤过,合并提取液并浓缩至相对密度1.10-1.20(室温),得到水提浸膏;
将醇提浸膏和水提浸膏合并,真空干燥,即得。
实施例3
本实施例提供了一种治疗偏头痛的中药组合物的制备
取白芍17g、天麻12g、细辛6g和柴胡12g,加其重量之和5-8倍的体积百分含量为60-75%的乙醇溶液作提取溶剂,回流提取2次,每次1.5h,滤过,合并两次提取液并浓缩至相对密度1.10-1.20(室温),得到醇提浸膏和药渣;
将沙苑子17g、川芎17g、当归22g、延胡索22g、丹参17g、桃仁12g、红花10g、附子4g、羌活12g、防风12g、桑叶12g、甘菊花12g、苍术12g和甘草12g投至所述药渣中,加所述药渣和沙苑子、川芎等药材的总体积的8-10倍的水作提取溶剂,煎煮提取2次,每次1.5h,滤过,合并提取液并浓缩至相对密度1.10-1.20(室温),得到水提浸膏;
将醇提浸膏和水提浸膏合并,真空干燥,即得。
实施例4
本实施例提供了一种治疗偏头痛的中药组合物的制备
取白芍20g、天麻15g、细辛7g和柴胡15g,加其重量之和5-8倍的体积百分含量为60-75%的乙醇溶液作提取溶剂,回流提取2次,每次1.5h,滤过,合并两次提取液并浓缩至相对密度1.10-1.20(室温),得到醇提浸膏和药渣;
将沙苑子20g、川芎20g、当归25g、延胡索25g、丹参20g、桃仁15g、红花12g、附子5g、羌活15g、防风15g、桑叶15g、甘菊花15g、苍术15g和甘草15g投至所述药渣中,加所述药渣和沙苑子、川芎等药材的总体积的8-10倍的水作提取溶剂,煎煮提取2次,每次1.5h,滤过,合并提取液并浓缩至相对密度1.10-1.20(室温),得到水提浸膏;
将醇提浸膏和水提浸膏合并,真空干燥,即得。
实施例5
本实施例提供了一种治疗偏头痛的中药制剂
按照常规的药品生产工艺,对实施例1-4所述的中药组合物加入适宜的矫味剂或甜味剂,制成颗粒剂;加入适宜的辅料,制成片剂、口服液、滴丸剂或胶囊剂等。
实施例6
本实施例提供了本发明治疗偏头痛的中药组合物的药效试验
1.急性及慢性毒理实验研究
取健康Wistar雌性小鼠20只,体重(20±2)g,用作急性毒理实验;取健康Wistar雄性大鼠30只,体重(200±20)g,用作慢性毒理实验。普通饮水,室温控制在(24±3)℃,湿度(50±10)%,自然光照。
1.1急性毒理实验
1.1.1实验方法
将20只雌性小鼠随机分为两组,药物组和对照组,每组10只。药物组按0.48g/20g体重量灌服本发明中药组合物,每日1次;对照组予1mL/20g体重量0.9%氯化钠注射液剂量灌胃。实验周期为7天,观察并记录给药7天内小鼠的活动、摄食、排泄及死亡等情况。
1.1.2实验结果
小鼠在给药7天内无死亡,给药后观察小鼠外观、毛色、光泽正常,社会行为、反应均正常,摄食、排泄正常。人工处死解剖,观察其心脏、肝脏、脾脏、肺脏、肾脏、脑均未见异常。
1.2慢性毒理实验
1.2.1实验方法
将30雄性大鼠随机分为两组,药物组和对照组,每组15只。药物组按每只大鼠0.05g的中药剂量灌服;对照组予1mL/20g体质量0.9%氯化钠注射液。两组均为每日1次,实验周期为1个月。观察并记录大鼠的外观、毛色,社会行为(躁动、冷漠、探究活动),刺激性(好斗)等和对周围环境、食物、水的兴趣等,体质量变化,记录有无中途死亡。
1.2.2实验结果
药物组和对照组的大鼠在给药30天内无死亡,且外观、毛色,社会行为、刺激性等和对周围环境、食物、水的兴趣等比较差异均无统计学意义(P>0.05)。两组大鼠实验后体质量均较本组实验前增加(P<0.05),但两组实验后体质量比较差异均无统计学意义(P>0.05)。
以上实验结果表明,本发明治疗偏头痛的中药组合物口服安全,无明显的急性及慢性毒副作用,可以在临床进一步推广使用。
2.临床资料研究
2.1病例纳入标准
1)偏头痛病程≥1年;
2)年龄18-65岁,首发年龄≤50岁
3)近12周,每4周头痛发作次数为2-6次;
4)患者入组前12周内未服用过有预防偏头痛发作功效的药物。
2.2病例来源及分组
患者来源:2017年1月-2019年3月就诊患者36例。将患者随机分为治疗组和对照组,各组18例,其中男性16例,女性20例,最大年龄65岁,最小年龄22岁,病程时间不等,两组患者年龄、性别、病程等各项基本资料基本相同,差异无统计学意义(P>0.05)。患者知情同意。
2.3治疗方法
治疗组:实施例3制备的中药组合物,用药量0.8g/次,每日3次,饭后服用;
对照组:正天胶囊,每次2颗(0.45g/颗),每日3次,饭后服用。治疗期间停止其他中西药治疗。
连续治疗12周,并在第4、8、12周末及治疗结束4周后随访。
2.4疗效评定标准
具体头痛发作及中医证候评分详见附表1。
疗效判定标准如下:
痊愈:证候积分减少≥95%;
显效:70%≤证候积分减少<95%;
有效:30%≤证候积分减少<70%;
无效:证候积分减少<30%。
表1-中医症候症状体征分级评分
2.5治疗结果
2.5.1偏头痛发作次数及次数
治疗及随访过程中头痛发作天数及次数对照,见表2。
表2-治疗及随访过程中头痛发作天数及次数对照
通过表2可知,服药后治疗组和对照组的发作天数和次数均出现下降,尤其在治疗12周以后,治疗组的发作天数和次数明显低于对照组,说明本发明中药组合物治疗偏头痛具有更好的临床效果。
2.5.2间痛持续时间
治疗及随访过程中间痛持续时间对照,见表3。
表3-治疗及随访过程中间痛持续时间对照(小时)
组别 | 例数 | 4周 | 8周 | 12周 | 随访期 |
治疗组 | 18 | 22.36±12.90 | 16.75±10.98 | 3.12±1.97 | 5.25±2.78 |
对照组 | 18 | 30.32±16.81 | 21.44±12.61 | 8.05±5.19 | 14.37±9.99 |
通过表3可知,服药后治疗组和对照组的间痛持续时间均出现下降,尤其在治疗8周以后,治疗组的间痛持续时间明显低于对照组,说明本发明中药组合物治疗偏头痛具有更好的临床效果。
2.5.3治疗结束后中医证候临床疗效
治疗12周后中医证候临床疗效对照,见表4。
表4-治疗12周后中医证候临床疗效对照
通过表4可知,治疗组和对照组均对偏头痛有较好地疗效,但本发明中药组合物治疗的痊愈率及显效率明显高于对照组,说明本发明具有更好地临床治疗效果。
通过上述对比可知,本发明中药组合物在临床治疗风阳挟瘀型偏头痛中具有良好的临床效果,能有效提高治疗的痊愈率,值得在临床应用上推广。
以上所述,仅为本发明较佳的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术的技术人员在本发明批露的技术范围内,根据本发明的技术方案及其发明构思加以等同替换或改变,都应涵盖在本发明的保护范围之内。
Claims (10)
1.一种治疗偏头痛的中药组合物,其特征在于,由以下重量份的原料制成:川芎12-20份、当归15-25份、延胡索15-25份、白芍12-20份、丹参12-20份、天麻8-15份、桃仁8-15份、红花6-12份、附子2-5份、羌活8-15份、防风8-15份、细辛5-10份、桑叶8-15份、甘菊花8-15份、沙苑子12-20份、柴胡8-15份、苍术8-15份、甘草8-15份。
2.根据权利要求1所述的治疗偏头痛的中药组合物,其特征在于,由以下原料制成:川芎15-20份、当归20-25份、延胡索20-25份、白芍15-20份、丹参15-20份、天麻10-15份、桃仁10-15份、红花8-12份、附子3-5份、羌活10-15份、防风10-15份、细辛5-7份、桑叶10-15份、甘菊花10-15份、沙苑子15-20份、柴胡10-15份、苍术10-15份、甘草10-15份。
3.根据权利要求1所述的治疗偏头痛的中药组合物,其特征在于,由以下原料制成:川芎17份、当归22份、延胡索22份、白芍17份、丹参17份、天麻12份、桃仁12份、红花10份、附子4份、羌活12份、防风12份、细辛6份、桑叶12份、甘菊花12份、沙苑子17份、柴胡12份、苍术12份、甘草12份。
4.一种治疗偏头痛的中药组合物的制备方法,其特征在于,包括步骤:
取白芍、天麻、细辛和柴胡,加乙醇溶液作提取溶剂,回流提取,滤过,合并提取液并浓缩,得到醇提浸膏和药渣;
将沙苑子、川芎、当归、延胡索、丹参、桃仁、红花、附子、羌活、防风、桑叶、甘菊花、苍术和甘草投至所述药渣中,加水作提取溶剂,煎煮提取,滤过,合并提取液并浓缩,得到水提浸膏;
将醇提浸膏和水提浸膏合并,干燥,得到中药组合物。
5.根据权利要求4所述的制备方法,其特征在于,所述乙醇溶液的体积百分含量为60-75%,乙醇溶液的加入量为白芍、天麻、细辛和柴胡重量之和的5-8倍,回流提取的次数为2-3次,每次回流提取的时间为0.5-2h。
6.根据权利要求4所述的制备方法,其特征在于,水的用量为沙苑子、川芎、当归、延胡索、丹参、桃仁、红花、附子、羌活、防风、桑叶、甘菊花、苍术、甘草和所述药渣的总体积的8-10倍,每次煎煮提取的时间为0.5-1h。
7.根据权利要求4所述的制备方法,其特征在于,所述醇提浸膏和水提浸膏浓缩至相对密度1.10-1.20。
8.根据权利要求1-3任一所述中药组合物在制备治疗偏头痛药物中的应用。
9.一种治疗偏头痛的中药制剂,其特征在于,包括权利要求1-3任一所述中药组合物和药学上可接受的辅料。
10.根据权利要求9所述的治疗偏头痛的中药制剂,其特征在于,所述中药制剂的剂型为胶囊剂、片剂、颗粒剂、滴丸剂或口服液。
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