CN111375047A - Traditional Chinese medicine composition for treating dysmenorrhea and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating dysmenorrhea and preparation method and application thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating dysmenorrhea, and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-30 parts of fennel, 20-30 parts of fructus evodiae, 10-20 parts of dried ginger, 15-30 parts of cassia twig, 15-30 parts of pepper, 5-10 parts of corydalis tuber and 5-10 parts of mint. The traditional Chinese medicine composition provided by the invention can effectively treat primary dysmenorrhea and related symptoms caused by dysmenorrhea, and has no side effect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating dysmenorrhea, and a preparation method and application thereof.
Background
The primary dysmenorrhea has serious influence on the reduction of the life quality of patients, and severe patients also cause infertility, so the symptom becomes a great hot problem in current gynecological research. In the treatment of primary dysmenorrhea, nonsteroidal anti-inflammatory drugs are used for treatment, namely analgesic drug treatment, although the nonsteroidal anti-inflammatory drugs have certain treatment effect on dysmenorrhea. However, when the conventional medicine with the analgesic effect is used for treating primary dysmenorrhea, the gastrointestinal tract is stimulated, and meanwhile, the drug resistance is increased. When hormone medicines are used for treating dysmenorrhea, the hormone level of a patient is influenced, and adverse reactions are more.
With the progress of traditional Chinese medicine, traditional Chinese medicines are also increasingly applied to treating primary dysmenorrhea and relieving the pain of patients with dysmenorrhea. However, conventional drug therapy is often accompanied by a long course of treatment and a decoction with a poor taste, greatly reducing the coordination of patients. Acupuncture therapy is not suitable for modern fast-paced habits and customs.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition for treating dysmenorrhea and a preparation method and application thereof. The traditional Chinese medicine composition provided by the invention can effectively treat dysmenorrhea and related symptoms caused by dysmenorrhea, and is short in curative effect and quick in response.
The invention provides a traditional Chinese medicine composition for treating dysmenorrhea, which comprises the following components in parts by weight: 10-30 parts of fennel, 20-30 parts of fructus evodiae, 10-20 parts of dried ginger, 15-30 parts of cassia twig, 15-30 parts of pepper, 5-10 parts of corydalis tuber and 5-10 parts of mint.
Preferably, the composition comprises the following components in parts by weight: 20 parts of fennel, 30 parts of fructus evodiae, 20 parts of dried ginger, 20 parts of cassia twig, 20 parts of pepper, 10 parts of corydalis tuber and 5 parts of mint.
The invention also provides a preparation method of the traditional Chinese medicine composition in the technical scheme, which comprises the following steps: pulverizing the above materials to obtain pulverized material, and sterilizing the pulverized material by irradiation to obtain the Chinese medicinal composition.
Preferably, the pulverization comprises: performing first crushing on the components to obtain a first crushed material, wherein the particle size of the first crushed material is less than or equal to 850 mu m; and performing second grinding on the first ground material to obtain a ground material, wherein the grain diameter of the ground material is less than or equal to 48 mu m.
Preferably, the irradiation dose of the irradiation sterilization is 10-13 KGY, and the irradiation sterilization time is 12-16 hours.
The invention also provides application of the traditional Chinese medicine composition provided by the technical scheme in preparation of a medicine for treating dysmenorrhea.
The invention provides a traditional Chinese medicine composition for treating dysmenorrhea, which comprises the following components in parts by weight: 10-30 parts of fennel, 20-30 parts of fructus evodiae, 10-20 parts of dried ginger, 15-30 parts of cassia twig, 15-30 parts of pepper, 5-10 parts of corydalis tuber and 5-10 parts of mint. In the invention, fennel can dispel cold and relieve pain; the fructus evodiae regulates qi, eliminates dampness and relieves pain; zingiberis rhizoma has effects of warming spleen and stomach for dispelling cold, restoring yang and dredging collaterals, eliminating dampness and eliminating phlegm, and can be used for treating abdominal psychroalgia, cold limbs and slight pulse; ramulus Cinnamomi has effects of warming and dredging channels and collaterals, dispelling cold and relieving pain, and can be used for treating pain due to blood stagnation caused by cold; the pepper dispels cold, removes dampness and relieves pain; yan Hu Suo is good at activating blood and dissipating stasis, regulating qi and alleviating pain; mint can relieve abdominal pain. The formula has the effects of warming and activating channels, warming middle-jiao to dispel cold, promoting blood circulation to remove blood stasis, regulating qi and relieving pain, and can effectively treat cold-coagulation blood stasis type primary dysmenorrhea.
The results of the examples show that the traditional Chinese medicine composition provided by the invention can achieve the technical effect of treating dysmenorrhea, the effective rate of treating dysmenorrhea symptoms reaches 95%, the discomfort caused by dysmenorrhea is effectively relieved, and the effective rate of relieving pain reaches 80%.
Detailed Description
The invention provides a traditional Chinese medicine composition for treating dysmenorrhea, which comprises the following components in parts by weight: 10-30 parts of fennel, 20-30 parts of fructus evodiae, 10-20 parts of dried ginger, 15-30 parts of cassia twig, 15-30 parts of pepper, 5-10 parts of corydalis tuber and 5-10 parts of mint; preferably comprising: 20 parts of fennel, 30 parts of fructus evodiae, 20 parts of dried ginger, 20 parts of cassia twig, 20 parts of pepper, 10 parts of corydalis tuber and 5 parts of mint. The source of the traditional Chinese medicine components is not particularly limited, and the traditional Chinese medicine components can be prepared by adopting conventional commercial products.
In the invention, the fennel and the evodia are monarch drugs; rhizoma Zingiberis and ramulus Cinnamomi as ministerial drugs; the pricklyash peel, corydalis tuber and mint are used as adjuvant and guiding drugs. The traditional Chinese medicine composition is used together with various medicines, and has the effects of treating dysmenorrhea and relieving discomfort caused by the dysmenorrhea.
The invention also provides a preparation method of the traditional Chinese medicine composition in the technical scheme, which comprises the following steps: pulverizing the above materials to obtain pulverized material, and sterilizing the pulverized material by irradiation to obtain the Chinese medicinal composition.
In the present invention, the component is further preferably subjected to pulverization treatment including: performing first crushing on the components to obtain a first crushed material, wherein the particle size of the first crushed material is preferably less than or equal to 850 mu m; and second pulverizing the first pulverized material to obtain a pulverized material, wherein the particle size of the pulverized material is preferably 48 μm or less. The contact area of the components and the solvent can be increased by crushing the components, the diffusion surface is larger, the plant cells can be effectively destroyed after being crushed, and the effective substances are released, so that the treatment efficiency is improved.
The irradiation object is obtained by performing irradiation sterilization on the crushed object, the irradiation dose of the irradiation sterilization is preferably 10-13 KGY, more preferably 13KGY, and the irradiation sterilization time is preferably 12-16 hours, more preferably 16 hours. In the invention, the irradiation dose and time in the irradiation step have no obvious influence on the content and the effect of the effective components contained in the crushed material, and the crushed material can be ensured to achieve the sterilization effect.
In the invention, the traditional Chinese medicine composition is preferably used after being mixed with ethanol solution; the volume percentage content of the ethanol solution is preferably 50-70%, and more preferably 60%. In the invention, the mass ratio of the ethanol solution to the traditional Chinese medicine composition is preferably 1-2: 2-4, and more preferably 2: 3. In the invention, the ethanol solution is used as an adhesive, which not only can achieve the effect of bonding the components together, but also can assist the release of effective substances in the components and promote the absorption of a human body.
The invention also provides application of the traditional Chinese medicine composition in the technical scheme in preparation of medicines for treating dysmenorrhea.
In the present invention, the method for using the Chinese medicinal composition preferably comprises: the traditional Chinese medicine composition is prepared into pills for use, the mass of the pills is 0.2-0.5 g, the pills begin to be used 4-5 days before a physiological period, and the pills stop being used after the physiological period. The application period is preferably once a day, and preferably the navel is applied before sleep at night.
For further illustration of the present invention, the following examples are provided to describe the Chinese medicinal composition of the present invention in detail, but they should not be construed as antecedent to the scope of the present invention.
Example 1
Taking 10g of fennel, 20g of fructus evodiae, 10g of dried ginger, 15g of cassia twig, 15g of pepper, 5g of rhizoma corydalis and 5g of mint. The components are crushed and then sieved by a 20-mesh sieve, and then the superfine crushing is carried out and the sieved by a 300-mesh sieve. Then radiation sterilization is carried out, the radiation dose is 13KGY, and the time is 16 hours, thus obtaining the traditional Chinese medicine composition.
Example 2:
taking 30g of fennel, 30g of fructus evodiae, 20g of dried ginger, 30g of cassia twig, 30g of pepper, 10g of rhizoma corydalis and 10g of mint. The components are crushed and then sieved by a 20-mesh sieve, and then the superfine crushing is carried out and the sieved by a 300-mesh sieve. Then radiation sterilization is carried out, the radiation dose is 12KGY, and the time is 14 hours, thus obtaining the traditional Chinese medicine composition.
Example 3:
taking 15g of fennel, 25g of fructus evodiae, 15g of dried ginger, 23g of cassia twig, 23g of pepper, 8g of rhizoma corydalis and 8g of mint. The components are crushed and then sieved by a 20-mesh sieve, and then the superfine crushing is carried out and the sieved by a 300-mesh sieve. Then radiation sterilization is carried out, the radiation dose is 10KGY, and the time is 12 hours, thus obtaining the traditional Chinese medicine composition.
Application example 1
1. Patient inclusion criteria:
1) congealing cold and blood stasis type primary dysmenorrhea volunteers (refer to diagnosis standard of traditional Chinese medicine gynecology, and the age is 18-30 years old;
2) those with regular menstrual cycles;
3) no pain relievers or other hormonal drugs were taken within 2 weeks.
2. 80 primary dysmenorrhea patients with congealing cold and blood stasis type were collected from 2018, 3-2018, 11 and divided into control group and test group, each group containing 40 patients, on the basis of grouping (with different treatment measures). Control group: the patients are 16-31 years old, the mean (29 +/-10) years old, the course of disease is 12-140 months, and the mean (75 +/-11) months. Test groups: patients were 17-33 years old, mean (30 ± 10) years old, course of disease: 12-150 months, and average (82 +/-11) months. The basic data (average age, average course of disease and the like) of the test group and the control group are compared, and the difference is not obvious and has no statistical significance (P is more than 0.05).
4. Method of treatment
Observation group: 4-5 days before the beginning of the physiological period and before the sleep of the patient at night every day, taking a proper amount of the traditional Chinese medicine composition and an ethanol solution with the concentration of 60% to be uniformly mixed according to the mass ratio of 2:3, and preparing the mixture into pills to be applied to the navel.
Control group: moxibustion umbilicus treatment is carried out on cold-congealing blood stasis type dysmenorrheal volunteers in non-menstrual periods, 30min is carried out each time, 1 time is carried out every 2 days, and 15 times of continuous treatment are carried out.
5. Standard of therapeutic effect
The clinical characteristics of the dysmenorrhea are combined, and the pain and the relief degree of all symptoms including the pain are drawn up as the treatment effect judgment standard.
Effective pain relief rates (scored according to VAS visual simulation) were found in the relevant literature (pain science, 3 rd edition):
1) the pain completely disappears or is obviously relieved after treatment, and the Visual Analogue Score (VAS) after treatment is reduced by more than 80 percent compared with that before treatment;
2) improvement, the pain is relieved after treatment, and the Visual Analogue Score (VAS) after treatment is reduced by 30 to 80 percent compared with that before treatment;
3) no significant improvement in pain upon treatment, and less than 30% reduction in Visual Analogue Score (VAS) after treatment compared to pre-treatment.
Effective rate of treating dysmenorrhea (according to dysmenorrhea integral evaluation standard):
1) recovering, wherein the integral is recovered to 0 point after treatment, the abdominal pain and other symptoms disappear, and the patient does not relapse after stopping taking the medicine for 3 months;
2) the curative score is reduced to be below 50 percent of the score before treatment, the abdominal pain is obviously relieved, the symptoms are obviously improved, and the patient can insist on working without taking analgesic;
3) has the advantages that the score after treatment is as low as 50 to 75 percent of the score before treatment, the abdominal pain is relieved, and other symptoms are improved and can work continuously;
4) no effect, abdominal pain and unchanged symptoms.
Comparison of dysmenorrhea symptoms before and after treatment: after 1 month of treatment, comparing the VAS visual simulation score, the dysmenorrhea symptom score and the dysmenorrhea time after treatment with those before treatment, the difference has statistical significance (p is less than 0.01), wherein the pain relieving effective rate is as high as 80%, the dysmenorrhea symptom treatment effective rate is 95%, and the statistical result is shown in Table 1.
TABLE 1 statistics of symptoms for the observed and control groups
As can be seen from table 1, the traditional Chinese medicine composition provided by the invention not only can effectively treat primary dysmenorrhea, but also can effectively relieve pain of affected parts of patients, thereby greatly relieving pain of patients caused by dysmenorrhea.
Application example 2
Case 1
The Chinese medicinal composition provided by the embodiment 1 of the invention is used by a person in Wangzhi, a woman 24 years old and Guangzhou city after clinical diagnosis for primary dysmenorrhea due to cold coagulation, the course of disease is 5 years, and 5 months in 2019, a proper amount of the Chinese medicinal composition is uniformly mixed with 60% ethanol solution in a mass ratio of 2:3, the mixture is prepared into pills to be applied to the navel, the treatment is continuously carried out for 1 month, the dysmenorrhea of a patient is cured, the abdominal pain and other symptoms disappear, and the menstrual cycle does not relapse after stopping the medicine for 3 months.
Case 2
The traditional Chinese medicine composition provided by the embodiment 2 of the invention is used by a woman in 30 years old or Changsha city after clinical diagnosis of cold coagulation and blood stasis primary dysmenorrhea, the course of disease is 10 years, and 6 months in 2019, a proper amount of the traditional Chinese medicine composition is uniformly mixed with 60% ethanol solution in a mass ratio of 2:3, the mixture is prepared into pills to be applied to the navel, 1 month of continuous treatment is carried out, the dysmenorrhea of a patient is cured, the abdominal pain and other symptoms disappear, and the menstrual cycle does not relapse after the patient stops taking the medicine for 3 months.
Case 3
According to clinical diagnosis of a patient with primary dysmenorrhea caused by congealing cold in Jiangyao, the patient is in age 28 and Dongguan city, the traditional Chinese medicine composition provided by the embodiment 3 is used in 8 years in the course of disease and in 1 month in 2019, a proper amount of the traditional Chinese medicine composition is uniformly mixed with an ethanol solution with the concentration of 60% according to the mass ratio of 2:3, the mixture is prepared into pills to be applied to the navel, the patient is continuously treated for 1 month, the dysmenorrhea of the patient is cured, the abdominal pain and other symptoms disappear, and the menstrual cycle does not relapse after the patient stops taking the medicine for 3 months.
Although the present invention has been described with reference to the preferred embodiments, it should be understood that various changes and modifications can be made therein by those skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (6)
1. The traditional Chinese medicine composition for treating dysmenorrhea is characterized by comprising the following components in parts by weight: 10-30 parts of fennel, 20-30 parts of fructus evodiae, 10-20 parts of dried ginger, 15-30 parts of cassia twig, 15-30 parts of pepper, 5-10 parts of corydalis tuber and 5-10 parts of mint.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following components in parts by weight: 20 parts of fennel, 30 parts of fructus evodiae, 20 parts of dried ginger, 20 parts of cassia twig, 20 parts of pepper, 10 parts of corydalis tuber and 5 parts of mint.
3. The method for preparing the traditional Chinese medicine composition of claim 1 or 2, which is characterized by comprising the following steps: pulverizing the above materials to obtain pulverized material, and sterilizing the pulverized material by irradiation to obtain the Chinese medicinal composition.
4. The method of manufacturing according to claim 3, wherein the pulverization includes: performing first crushing on the components to obtain a first crushed material, wherein the particle size of the first crushed material is less than or equal to 850 mu m; and performing second grinding on the first ground material to obtain a ground material, wherein the grain diameter of the ground material is less than or equal to 48 mu m.
5. The preparation method according to claim 3, wherein the irradiation dose for the irradiation sterilization is 10 to 13KGY, and the irradiation sterilization time is 12 to 16 hours.
6. Use of a Chinese medicinal composition according to claim 1 or 2 in the preparation of a medicament for the treatment of dysmenorrhea.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850267A (en) * | 2006-02-21 | 2006-10-25 | 贵州绿太阳制药有限公司 | Ointment of treating dysmenorrhea, its preparing method and quality control method |
| CN104983989A (en) * | 2015-06-25 | 2015-10-21 | 广州中医药大学 | Traditional Chinese medicine drug for treating dysmenorrheal and gel paste and preparation method thereof |
| CN108261465A (en) * | 2018-04-09 | 2018-07-10 | 朱时祥 | It is a kind of treat cold obstruction causing qi stagnation caused by dysmenorrhoea external preparation and preparation method thereof |
-
2020
- 2020-05-21 CN CN202010438885.9A patent/CN111375047A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850267A (en) * | 2006-02-21 | 2006-10-25 | 贵州绿太阳制药有限公司 | Ointment of treating dysmenorrhea, its preparing method and quality control method |
| CN104983989A (en) * | 2015-06-25 | 2015-10-21 | 广州中医药大学 | Traditional Chinese medicine drug for treating dysmenorrheal and gel paste and preparation method thereof |
| CN108261465A (en) * | 2018-04-09 | 2018-07-10 | 朱时祥 | It is a kind of treat cold obstruction causing qi stagnation caused by dysmenorrhoea external preparation and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 任艳玲等: "《药性歌括四百味应用新解》", 31 July 2011 * |
| 何国兴: "药敷涌泉穴治妇科病", 《家庭医学》 * |
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Application publication date: 20200707 |