CN111375045A - 利胆消石组合物 - Google Patents
利胆消石组合物 Download PDFInfo
- Publication number
- CN111375045A CN111375045A CN202010392045.3A CN202010392045A CN111375045A CN 111375045 A CN111375045 A CN 111375045A CN 202010392045 A CN202010392045 A CN 202010392045A CN 111375045 A CN111375045 A CN 111375045A
- Authority
- CN
- China
- Prior art keywords
- parts
- cholagogic
- calculus
- composition
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 48
- 206010008635 Cholestasis Diseases 0.000 title description 43
- 230000007870 cholestasis Effects 0.000 title description 35
- 231100000359 cholestasis Toxicity 0.000 title description 35
- 239000003814 drug Substances 0.000 claims abstract description 94
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 27
- 239000002994 raw material Substances 0.000 claims abstract description 21
- 244000274050 Platycodon grandiflorum Species 0.000 claims abstract description 13
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims abstract description 13
- 230000002279 cholagogic effect Effects 0.000 claims abstract 12
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract 5
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract 5
- 235000011477 liquorice Nutrition 0.000 claims abstract 5
- 241001116477 Adenophora triphylla Species 0.000 claims abstract 3
- 244000273928 Zingiber officinale Species 0.000 claims abstract 3
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract 3
- 210000003038 endothelium Anatomy 0.000 claims abstract 3
- 235000008397 ginger Nutrition 0.000 claims abstract 3
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract 3
- 241001571764 Lysimachia christinae Species 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
- 229940079593 drug Drugs 0.000 claims description 19
- 239000000463 material Substances 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 9
- 239000002552 dosage form Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 238000002791 soaking Methods 0.000 claims description 6
- 241000132012 Atractylodes Species 0.000 claims description 5
- 241001522129 Pinellia Species 0.000 claims description 5
- 240000004534 Scutellaria baicalensis Species 0.000 claims description 5
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims description 5
- 239000000731 choleretic agent Substances 0.000 claims description 4
- 230000001989 choleretic effect Effects 0.000 claims description 4
- 235000004347 Perilla Nutrition 0.000 claims 2
- 244000124853 Perilla frutescens Species 0.000 claims 2
- 244000197580 Poria cocos Species 0.000 claims 2
- 235000008599 Poria cocos Nutrition 0.000 claims 2
- 241000522190 Desmodium Species 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 201000001883 cholelithiasis Diseases 0.000 abstract description 27
- 208000001130 gallstones Diseases 0.000 abstract description 26
- 208000002193 Pain Diseases 0.000 abstract description 25
- 238000002360 preparation method Methods 0.000 abstract description 9
- 230000008506 pathogenesis Effects 0.000 abstract description 8
- 238000011160 research Methods 0.000 abstract description 4
- 208000027534 Emotional disease Diseases 0.000 abstract description 2
- 230000006698 induction Effects 0.000 abstract description 2
- 238000011282 treatment Methods 0.000 description 39
- 210000004185 liver Anatomy 0.000 description 37
- 235000014347 soups Nutrition 0.000 description 24
- 241000202807 Glycyrrhiza Species 0.000 description 22
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 22
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 22
- 229940010454 licorice Drugs 0.000 description 22
- 230000000694 effects Effects 0.000 description 15
- 244000183685 Citrus aurantium Species 0.000 description 13
- 235000007716 Citrus aurantium Nutrition 0.000 description 13
- 235000000228 Citrus myrtifolia Nutrition 0.000 description 13
- 235000016646 Citrus taiwanica Nutrition 0.000 description 13
- 201000010099 disease Diseases 0.000 description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 13
- 210000000232 gallbladder Anatomy 0.000 description 13
- 239000004575 stone Substances 0.000 description 13
- 241000208340 Araliaceae Species 0.000 description 12
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 12
- 235000003140 Panax quinquefolius Nutrition 0.000 description 12
- 235000008434 ginseng Nutrition 0.000 description 12
- 244000025254 Cannabis sativa Species 0.000 description 10
- 208000024891 symptom Diseases 0.000 description 10
- 241000202726 Bupleurum Species 0.000 description 9
- 244000236658 Paeonia lactiflora Species 0.000 description 9
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 9
- 210000000952 spleen Anatomy 0.000 description 9
- 244000163122 Curcuma domestica Species 0.000 description 8
- 235000003392 Curcuma domestica Nutrition 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 8
- 235000003373 curcuma longa Nutrition 0.000 description 8
- 235000013976 turmeric Nutrition 0.000 description 8
- 235000005911 diet Nutrition 0.000 description 7
- 230000037213 diet Effects 0.000 description 7
- 210000004072 lung Anatomy 0.000 description 7
- 208000011580 syndromic disease Diseases 0.000 description 7
- 230000004069 differentiation Effects 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 230000001105 regulatory effect Effects 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 5
- 238000009825 accumulation Methods 0.000 description 5
- 210000000941 bile Anatomy 0.000 description 5
- 208000004998 Abdominal Pain Diseases 0.000 description 4
- 241000287828 Gallus gallus Species 0.000 description 4
- 208000031361 Hiccup Diseases 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 210000000038 chest Anatomy 0.000 description 4
- 230000002996 emotional effect Effects 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 241000736199 Paeonia Species 0.000 description 3
- 235000006484 Paeonia officinalis Nutrition 0.000 description 3
- 206010033372 Pain and discomfort Diseases 0.000 description 3
- 208000005392 Spasm Diseases 0.000 description 3
- 239000001774 alpinia officinarum Substances 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 208000020694 gallbladder disease Diseases 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 208000002513 Flank pain Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010020710 Hyperphagia Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 208000037093 Menstruation Disturbances Diseases 0.000 description 2
- 206010027339 Menstruation irregular Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 208000033809 Suppuration Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000003187 abdominal effect Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000009967 tasteless effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 210000003932 urinary bladder Anatomy 0.000 description 2
- LQIAZOCLNBBZQK-UHFFFAOYSA-N 1-(1,2-Diphosphanylethyl)pyrrolidin-2-one Chemical compound PCC(P)N1CCCC1=O LQIAZOCLNBBZQK-UHFFFAOYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010002953 Aphonia Diseases 0.000 description 1
- 206010004637 Bile duct stone Diseases 0.000 description 1
- 241000208671 Campanulaceae Species 0.000 description 1
- 201000009331 Choledocholithiasis Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 240000003173 Drymaria cordata Species 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 206010016952 Food poisoning Diseases 0.000 description 1
- 208000019331 Foodborne disease Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019705 Hepatic pain Diseases 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 241001522232 Pinellia ternata Species 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 241000207929 Scutellaria Species 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000005298 acute pain Diseases 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 208000027697 autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency Diseases 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000011337 individualized treatment Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 235000020830 overeating Nutrition 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 235000017924 poor diet Nutrition 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 210000001991 scapula Anatomy 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/342—Adenophora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种利胆消石组合物，包括以下重量份原料：甘草9～12份、炮姜9～12份、枳壳10～15份、柴胡15～20份、南沙参25～30份、桔梗10～15份、鸡内金10～15份、海金沙20～30份、金钱草10～15份和白芍10～15份。本发明还提供了利胆消石药物及其制备方法。本发明从中医理论的角度，通过总结胆结石的病机，突出情志致病的重要性，同时注重扶助正气；对胆结石的理论研究则更全面、更深入；以此方内服，效价比较高，有效解决了患者痛苦及经济负担较重、胆结石复发几率高和容易诱发并发症等问题。
Description
技术领域
本发明涉及中药配方技术领域，具体涉及一种利胆消石组合物。
背景技术
胆结石是一种常见的消化系统疾病，患者以右胸胁疼痛不适、隐痛，向肩背放射性疼痛，突发性绞痛为主要特征。近年来胆结石发病呈逐年增长趋势，且发病随年级增长而增加；现代医学认为发病因数较复杂，其发病往往是由于过多的摄入饮食所导致，一般口味重，喜食油腻、糖、脂肪、蛋白质的人容易患病，其病机主要是胆管内形成的凝结物。胆结石严重影响患者生活质量，常常伴有焦虑、抑郁、恐慌等情绪，从而增加了患者心理负担，严重影响患者生活质量和身心健康。
根据胆结石的大小，本病治疗目前采取的治疗方法是饮食控制、手术治疗、碎石、以及容石。本病虽治疗手段较多，但手术、体外碎石、容石给患者带来痛苦及经济负担，同时因为患者饮食及体质因数不能完全防止术后的复发，且容易诱发并发症，性价比较低，是消化内科疑难病之一。
关于胆石病中医历代医家没有专门论述，但在文献中记载：“黄疸”“结胸”“积聚”“胆胀”“女劳胆”的症状与本病相似；胆腑附于肝，内藏精汁，胆汁来源于肝，故前人有云肝之余气溢于胆，聚而成汁，胆汁注入肠道有促进消化的作用；因情绪不畅、肝气郁结，外邪内侵，虫积所伤，或因饮食不节过食肥甘厚味，均可导致肝的疏泄功能和胆的通降功能失常，造成气机不通，胆汁排泄不畅，胆汁淤积，湿热内蕴，煎灼日久成为砂石；又因胆为六腑以通为用，若胆汁淤积，血行不畅，则形成胆系疾病的症状。中医治疗主要是通过辨证论治来进行治疗。近代医家基于辨证论治的基础上主要从肝郁气滞、肝胆湿热内蕴、瘀血内阻、肝阴不足等论治；结石阻滞、肝胆疏泄不畅、气滞不调，不通则痛是本病发病的主要因素；治疗原则为疏肝利胆、化瘀通络。但是，他们忽视了“情志致病”“扶助正气”在治疗本病中的重要作用。
发明内容
针对现有技术中的上述不足，本发明提供了一种利胆消石组合物，从中医理论的角度，通过总结胆结石的病机，突出情志致病的重要性，同时注重扶助正气；对胆结石的理论研究则更全面、更深入；以此方内服，效价比较高，有效解决了患者痛苦及经济负担较重、胆结石复发几率高和容易诱发并发症等问题。
为实现上述目的，本发明解决其技术问题所采用的技术方案是：提供一种利胆消石组合物，包括以下重量份原料：甘草9～12份、炮姜9～12份、枳壳10～15份、柴胡15～20份、南沙参25～30份、桔梗10～15份、鸡内金10～15份、海金沙20～30份、金钱草10～15份和白芍10～15份。
进一步，利胆消石组合物包括以下重量份原料：甘草9份、炮姜9份、枳壳15份、柴胡15份、南沙参30份、桔梗10份、鸡内金10份、海金沙30份、金钱草10份和白芍15份。
进一步，利胆消石组合物还包括白术10～15份和茯苓15～20份。
进一步，利胆消石组合物还包括白术15份和茯苓20份。
进一步，利胆消石组合物还包括苏叶10～15份、枳壳10～15份、半夏10～15份和黄芩5～10g。
进一步，利胆消石组合物还包括苏叶12份、枳壳12份、半夏12份和黄芩9份。
其中，甘草性甘，平；归心、脾、肺、胃经。功效：补脾益气，润肺止咳，清热解毒，缓解止痛，缓和药性。主治：用于脾胃虚弱，气短乏力，心悸怔忡，咳嗽痰少，热毒疮疡，药食中毒，脘腹急痛，四肢挛痛。
炮姜性苦、涩，温；归脾、肝经。炮姜的功效温经止血，温中止痛。主治出血，腹痛腹泻。
枳壳性苦、辛、酸，微寒；归脾、胃经。具有理气宽中，行滞消胀之功效。常用于胸胁气滞，胀满疼痛，食积不化，痰饮内停，脏器下垂。
柴胡性苦、辛、微寒；归心包络、肝、胆、三焦经。功效：疏散退热，疏肝解郁，升举阳气。主治：用于感冒发热，寒热往来，胁肋胀痛，月经不调，脱肛，子宫脱垂。
南沙参性甘，微寒。归脾、肺经。具有清肺养阴，益胃生津之功效。主治：用于肺热燥咳，阴虚劳嗽，津伤口渴。
桔梗性苦、辛，平；归肺经。功效：宣肺，利咽，祛痰，排脓。主治：用于咳嗽痰多，咽痛，失音，肺痈吐脓。
鸡内金性甘，平；归脾、胃、小肠、膀胱经。具有健胃消食，固精止遗的功效。主要用于食积不化，小儿疳积，遗尿遗精，石淋。
海金沙性甘，寒；归小肠、膀胱经。功效：利水通淋。主治：用于热淋、石淋，全身肿满。
金钱草性甘、咸，微寒；归肝、胆、肾、膀胱经。功效：利水通淋，利湿退黄，解毒消肿。主治：用于热淋，石淋，湿热黄疸，恶疮肿毒，毒蛇咬伤。
白芍性苦、酸，微寒，归肝、脾经；功效：养血敛阴，柔肝止痛，平抑肝阳。主用于月经不调，崩漏，虚汗，脘腹急痛，胁肋疼痛，四肢挛痛，头痛眩晕。
一种利胆消石药物，包括上述的利胆消石组合物，其剂型为中药汤剂或粉剂。
上述利胆消石药物的制备方法，其特征在于，包括以下步骤：
(1)将清洗后的利胆消石组合物原料用清水浸泡15～20min，大火烧开后文火慢熬15～20min，得煎煮后药材和中药汤汁一；甘草和清水的质量体积比为90～120:4g/L；
(2)将步骤(1)所得煎煮后药材加清水后文火慢熬20～30min，得中药汤汁二；甘草和清水的质量体积比为90～120:1g/L；
(3)将步骤(1)所得中药汤汁一和步骤(2)所得中药汤汁二混合，得中药汤剂。
上述利胆消石药物的制备方法，包括以下步骤：将清洗后的利胆消石组合物原料碾碎成细粉，得粉剂。
综上所述，本发明具有以下优点：
1、本发明为快速缓解患者的病痛，使该病的治疗疗效安全，所使用结石治疗处方在消石基础上，更加强调情志致病在该病中的地位，以注重疏肝调畅气机，兼以扶助正气。因此，对治疗胆结石的理论研究则更全面、更深入。利胆消石组合物则是在疏肝调场气机，佐以活血之品为主的基础上，根据中医理论“肝喜条达而恶抑郁”的理论重用疏肝理气调畅情志的重要，对治疗胆结石的主方结构则更加完善。经过多年的临床观察，利胆消石组合物治疗胆结石的效果明显，较单纯西医治疗优势明显，且毒副作用小，复发率低，有助于患者身心健康。
2、利胆消石组合物从中医理论的角度，通过总结胆结石的病机，突出本病中情志致病的重要性，同时注重扶助正气；对胆结石的理论研究则更全面、更深入。从而在治疗方面提出在消石基础上，更加强调情志致病在该病中的地位，同时扶助正气；总结出根据肝的生理特性“体阴而用阳”，重用芍药以柔肝软肝，兼以注重疏肝调畅气机，扶助正气的治疗方案；治疗胆结石的主方结构则更加完善。同时利胆消石组合物是在古代名方柴四逆散的基础上划裁，增加了鸡内金、海金沙、桔梗、炮姜、南沙参等药物，又经过临床的反复验证，终于总结提炼出有效治疗胆结石的处方，以此方内服，具有良好的效价比，减轻患者痛苦和经济负担，同时降低了胆结石复发几率。
3、组分配方中以四逆散为基础方，突出疏肝解郁、理气解痉止痛之功效；柴胡功善疏肝解郁，用以为君；芍药、甘草养血柔肝，缓急止痛，同时重用芍药，以达柔肝缓急止痛之效，柴芍同用补肝体而助肝用；鸡内金、海金沙、金钱草具有消石之功；“肺为水之上源”，方中桔梗取其宣通上焦、通利水道，以利胆石排除，枳壳苦温，理气宽中，以降泄下行之力为著，二药相配，一升一降，是宣降肺气，宽胸利膈的有效组合；炮姜温经止痛，佐助之功效；沙参益气扶正，既扶正祛邪，又防邪复入，有养阴滋阴之功效，以防处方中诸药伤及胃阴。诸药合用，可使肝胆疏利，郁结自解，气机调达运行畅达，肝得养，砂石自消。
4、本发明根据中医辨证论治的思维，提供的中药配伍科学合理，用药严谨。临床经验表明，有很好的治疗和预防作用；针对素体脾虚者，在基础配方上加入白术和茯苓；针对呃逆明显者，加大枳壳用量，并加入苏叶、半夏和黄芩；本发明的利胆消石组合物可根据病人的体质，或主要的兼证，灵活增加药物，体现了中医的个体化治疗，呈现了中医辨证论治的精髓。与单纯西医治疗，利胆消石组合物治疗本病则具有明显的优势，且副作用小，降低患者胆结石复发几率。
具体实施方式
实施例1
一种利胆消石组合物，包括以下重量份原料：甘草9份、炮姜9份、枳壳10份、柴胡15份、南沙参25份、桔梗10份、鸡内金10份、海金沙20份、金钱草10份和白芍10份。
一种利胆消石药物，包括上述的利胆消石组合物，其剂型为中药汤剂。
上述利胆消石药物的制备方法，包括以下步骤：
(1)将清洗后的利胆消石组合物原料清水浸泡20min，大火烧开后文火慢熬20min，得煎煮后药材和中药汤汁一；甘草和清水的质量体积比为90:4g/L；
(2)将步骤(1)所得煎煮后药材加清水后文火慢熬25min，得中药汤汁二；甘草和清水的质量体积比为90:1g/L；
(3)将步骤(1)所得中药汤汁一和步骤(2)所得中药汤汁二混合，得中药汤剂。
实施例2
一种利胆消石组合物，包括以下重量份原料：甘草9份、炮姜9份、枳壳15份、柴胡15份、南沙参30份、桔梗10份、鸡内金10份、海金沙30份、金钱草10份和白芍15份。
一种利胆消石药物，包括上述的利胆消石组合物，其剂型为中药汤剂。
上述利胆消石药物的制备方法，包括以下步骤：
(1)将清洗后的利胆消石组合物原料清水浸泡20min，大火烧开后文火慢熬20min，得煎煮后药材和中药汤汁一；甘草和清水的质量体积比为90:4g/L；
(2)将步骤(1)所得煎煮后药材加清水后文火慢熬25min，得中药汤汁二；甘草和清水的质量体积比为90:1g/L；
(3)将步骤(1)所得中药汤汁一和步骤(2)所得中药汤汁二混合，得中药汤剂。
实施例3
一种利胆消石组合物，包括以下重量份原料：甘草12份、炮姜12份、枳壳15份、柴胡20份、南沙参30份、桔梗15份、鸡内金15份、海金沙30份、金钱草15份和白芍15份。
一种利胆消石药物，包括上述的利胆消石组合物，其剂型为中药汤剂。
上述利胆消石药物的制备方法，包括以下步骤：
(1)将清洗后的利胆消石组合物原料清水浸泡20min，大火烧开后文火慢熬20min，得煎煮后药材和中药汤汁一；甘草和清水的质量体积比为12:4g/L；
(2)将步骤(1)所得煎煮后药材加清水后文火慢熬25min，得中药汤汁二；甘草和清水的质量体积比为12:1g/L；
(3)将步骤(1)所得中药汤汁一和步骤(2)所得中药汤汁二混合，得中药汤剂。
实施例4
一种利胆消石组合物，包括以下重量份原料：甘草9份、炮姜9份、枳壳15份、柴胡15份、南沙参30份、桔梗10份、鸡内金10份、海金沙30份、金钱草10份和白芍15份。
一种利胆消石药物，包括上述的利胆消石组合物，其剂型为粉剂。
上述利胆消石药物的制备方法，包括以下步骤：将清洗后的利胆消石组合物原料碾碎成细粉，得粉剂。
实施例5
一种利胆消石组合物，包括以下重量份原料：甘草9份、炮姜9份、枳壳15份、柴胡15份、南沙参30份、桔梗10份、鸡内金10份、海金沙30份、金钱草10份、白芍15份、白术15份和茯苓20份。
一种利胆消石药物，包括上述的利胆消石组合物，其剂型为中药汤剂。
上述利胆消石药物的制备方法，包括以下步骤：
(1)将清洗后的利胆消石组合物原料清水浸泡20min，大火烧开后文火慢熬20min，得煎煮后药材和中药汤汁一；甘草和清水的质量体积比为90:4g/L；
(2)将步骤(1)所得煎煮后药材加清水后文火慢熬25min，得中药汤汁二；甘草和清水的质量体积比为90:1g/L；
(3)将步骤(1)所得中药汤汁一和步骤(2)所得中药汤汁二混合，得中药汤剂。
实施例6
一种利胆消石组合物，包括以下重量份原料：甘草9份、炮姜9份、枳壳27份、柴胡15份、南沙参30份、桔梗10份、鸡内金10份、海金沙30份、金钱草10份、白芍15份、苏叶12份、半夏12份和黄芩9份。
一种利胆消石药物，包括上述的利胆消石组合物，其剂型为中药汤剂。
上述利胆消石药物的制备方法，包括以下步骤：
(1)将清洗后的利胆消石组合物原料清水浸泡20min，大火烧开后文火慢熬20min，得煎煮后药材和中药汤汁一；甘草和清水的质量体积比为90:4g/L；
(2)将步骤(1)所得煎煮后药材加清水后文火慢熬25min，得中药汤汁二；甘草和清水的质量体积比为90:1g/L；
(3)将步骤(1)所得中药汤汁一和步骤(2)所得中药汤汁二混合，得中药汤剂。
实验例1
从川北医学院附属医院门诊选取2014年1月至2019年1月累计5年共150例胆结石患者治疗观察治疗效果及复发情况。其中女性86例，男性64例，最大年纪60岁，最小年纪21岁。参照中华人民共和国中医药行业标准《中医病症诊断疗效标准》中胆结石的诊断及评定依据。
治疗：不需手术治疗的胆结石患者，采用本发明的中药配伍处方，根据患者病情轻重程度采取服用实施例2所得中药2～3个疗程(水煎服，一日3次，每日100mL；或打粉水冲服，早晚一次，一次10g，一副药服用一天半，15副为1个疗程)。
疗效标准：治愈：按照服药方案治疗3月后，各症状及临床体征消失，结石排出体外，已无疼痛感，其他客观检查指标均正常。显效：按照服药方案治疗3月后，各症状及临床体征减轻，结石部分排出体外，疼痛感减轻，其他客观检查指标明显改善。无效：按照服药方案治疗3月后，疼痛感没减轻，客观检查指标无变化。
治疗结果：对150例胆结石患者进行疗效观察，其中62例取得治愈效果，79例取得显效效果，9例无效，其中3年内复发患者2人。总治愈率41.3％，总显效率52.7％，总无效率6％，三年内复发率1.3％。
实验例2
病案1：陈某某，女，35岁，家住南充阆中市，家庭不和睦，与老公经常吵架；平时右肝区隐痛不适，在情绪激动后加重，在当地医院拍片显示胆结石，结石多成泥沙样。来门诊时：表情不舒，愁眉苦脸，肝区隐痛不适，善叹息，时有呃逆，饮食尚可，喜食油腻之品，舌质白，苔微黄，脉弦。
中医辨证分析：患者中年女性，因家庭不和睦，肝喜条达而恶抑郁，造成肝气机不通，胆汁排泄不畅，胆汁淤积，湿热内蕴，煎灼日久成为砂石；又因胆为六腑以通为用，若胆汁淤积，血行不畅，则形成胆系疾病的症状。
治疗：采用实施例6所得针对呃逆明显者的利胆消石组合物；同时嘱患者情绪舒畅，忌肥甘厚味，减少和丈夫吵架。服药方法：中药水煎服，饭后服用，1日三次，每次服药100mL，一副一天半，15副1疗程，服药1疗程后患者肝区隐痛症状消失，呃逆症状缓解；再嘱患者服药2个疗程，复查腹部彩超发现结石消失。
实验例3
病案2：张某某，男，58岁，家住南充仪陇县，平素喜食油腻，体型偏胖，在当地医院拍片显示多发性胆结石。来门诊时：肝区隐痛不适，肩胛骨有放射性疼痛，饮食不佳，食而无味，舌质白厚腻，苔微黄，脉弦。
中医辨证分析：患者老年男性，因饮食不节过食肥甘厚味，导致肝的疏泄功能和胆的通降功能失常，胆为六腑以通为用，若胆汁淤积，血行不畅，则形成胆系疾病的症状。
治疗：因患者年高不愿采取西医治疗方案，故服用中药治疗。采用实施例5所得针对素体脾虚者的利胆消石组合物；服药方法：中药水煎服，饭后服用，1日三次，每次服药100mL，一副一天半，15副1疗程，服药1疗程后患者肝区隐痛症状消失，饮食无味，食少纳差症状缓解；再嘱患者服药2个疗程，复查腹部彩超发现结石消失。
由上可知，本发明药物具有疏肝理气、解痉止痛之功效，用于治疗胆结石疗效好。经临床观察，具有良好的效价比，减轻患者痛苦和经济负担，服药时间延长，效果越好，复发率低。
虽然本发明的具体实施方式对本发明进行了详细地描述，但不应理解为对本专利的保护范围的限定。在权利要求书所描述的范围内，本领域技术人员不经创造性劳动即可作出的各种修改和变形仍属本专利的保护范围。
Claims (9)
1.利胆消石组合物，其特征在于，包括以下重量份原料：甘草9～12份、炮姜9～12份、枳壳10～15份、柴胡15～20份、南沙参25～30份、桔梗10～15份、鸡内金10～15份、海金沙20～30份、金钱草10～15份和白芍10～15份。
2.如权利要求1所述的利胆消石组合物，其特征在于，包括以下重量份原料：甘草9份、炮姜9份、枳壳15份、柴胡15份、南沙参30份、桔梗10份、鸡内金10份、海金沙30份、金钱草10份和白芍15份。
3.如权利要求1或2所述的利胆消石组合物，其特征在于，还包括白术10～15份和茯苓15～20份。
4.如权利要求3所述的利胆消石组合物，其特征在于，还包括白术15份和茯苓20份。
5.如权利要求1或2所述的利胆消石组合物，其特征在于，还包括苏叶10～15份、枳壳10～15份、半夏10～15份和黄芩5～10g。
6.如权利要求5所述的利胆消石组合物，其特征在于，还包括苏叶12份、枳壳12份、半夏12份和黄芩9份。
7.一种利胆消石药物，包括权利要求1～6任一项所述的利胆消石组合物，其剂型为中药汤剂或粉剂。
8.如权利要求7所述的利胆消石药物的制备方法，其特征在于，包括以下步骤：
(1)将清洗后的利胆消石组合物原料用清水浸泡15～20min，大火烧开后文火慢熬15～20min，得煎煮后药材和中药汤汁一；甘草和清水的质量体积比为90～120:4g/L；
(2)将步骤(1)所得煎煮后药材加清水后文火慢熬20～30min，得中药汤汁二；甘草和清水的质量体积比为90～120:1g/L；
(3)将步骤(1)所得中药汤汁一和步骤(2)所得中药汤汁二混合，得中药汤剂。
9.如权利要求7所述的利胆消石药物的制备方法，其特征在于，包括以下步骤：将清洗后的利胆消石组合物原料碾碎成细粉，得粉剂。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010392045.3A CN111375045A (zh) | 2020-05-11 | 2020-05-11 | 利胆消石组合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010392045.3A CN111375045A (zh) | 2020-05-11 | 2020-05-11 | 利胆消石组合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111375045A true CN111375045A (zh) | 2020-07-07 |
Family
ID=71214375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010392045.3A Pending CN111375045A (zh) | 2020-05-11 | 2020-05-11 | 利胆消石组合物 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111375045A (zh) |
-
2020
- 2020-05-11 CN CN202010392045.3A patent/CN111375045A/zh active Pending
Non-Patent Citations (2)
| Title |
|---|
| 冯敏: "逍遥散的解析与妇科运用", 《中国医药指南》 * |
| 李靖杰: "探讨72例中医排石汤药治疗胆结石临床效果", 《中国现代药物应用》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102475868A (zh) | 一种风湿药酒 | |
| CN104107398A (zh) | 一种治疗风湿性心脏病的中药组合物 | |
| CN102430097A (zh) | 一种治疗白癜风的中药 | |
| CN102727648A (zh) | 一种治疗白癜风的中药组合物 | |
| CN101897933A (zh) | 一种治疗白癜风的中成药 | |
| CN104258305A (zh) | 一种治疗慢性肝胆病的中药制剂 | |
| CN109091570B (zh) | 一种治疗硬皮病的中药 | |
| CN111375045A (zh) | 利胆消石组合物 | |
| CN102772536B (zh) | 一种治疗肝炎并发肝硬化腹水的中药组合物 | |
| CN101780259B (zh) | 一种治疗胃癌的中药 | |
| CN105169189A (zh) | 一种治疗甲减的药物 | |
| CN104667129B (zh) | 一种治疗风湿性心脏病的药物 | |
| CN104383403A (zh) | 一种治疗慢性胃炎的中药组合物 | |
| CN118001341B (zh) | 一种治疗过敏性鼻炎等免疫力低下引起的过敏性疾病的中药组合物、膏剂及其制备方法 | |
| CN102240384B (zh) | 一种治疗痰瘀互结型癫痫的药物及其制备方法 | |
| CN103656110B (zh) | 治疗肝郁气滞乳房胀痛的中药制剂及其制备方法 | |
| CN102698102A (zh) | 一种治疗慢性喉炎的中药组合物 | |
| CN100534477C (zh) | 一种内服治疗鼻咽癌的中药汤剂 | |
| CN105727148A (zh) | 一种治疗肝硬化腹水的药物及其制备 | |
| CN1059572C (zh) | 一种治疗类风湿和骨质增生的药物及其制备方法 | |
| CN105999060A (zh) | 一种治疗妇女血瘀型癥瘕的中药组合物及其制备方法 | |
| CN105194429A (zh) | 一种治疗支气管哮喘病的中药制剂 | |
| CN104623597A (zh) | 治疗癌症患者疼痛发热症药组合物及其制备方法 | |
| CN105232661A (zh) | 一种治疗乳腺炎的中药组合物及其制备方法 | |
| CN105727137A (zh) | 一种治疗糖尿病的中药 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200707 |