CN111263646A - 基于丝-透明质酸的组织填充物及其使用方法 - Google Patents

基于丝-透明质酸的组织填充物及其使用方法 Download PDF

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Publication number
CN111263646A
CN111263646A CN201880055268.1A CN201880055268A CN111263646A CN 111263646 A CN111263646 A CN 111263646A CN 201880055268 A CN201880055268 A CN 201880055268A CN 111263646 A CN111263646 A CN 111263646A
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China
Prior art keywords
tissue filler
spf
silk
kda
cross
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CN201880055268.1A
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English (en)
Chinese (zh)
Inventor
G.H.阿特曼
P.徐
E.金
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Natural Evolution Co
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Natural Evolution Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201880055268.1A 2017-06-26 2018-06-26 基于丝-透明质酸的组织填充物及其使用方法 Pending CN111263646A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762525131P 2017-06-26 2017-06-26
US62/525131 2017-06-26
US201862641095P 2018-03-09 2018-03-09
US62/641095 2018-03-09
PCT/US2018/039574 WO2019005848A1 (en) 2017-06-26 2018-06-26 HYALURONIC SILK ACID TISSUE FILLING AGENTS AND METHODS OF USE THEREOF

Publications (1)

Publication Number Publication Date
CN111263646A true CN111263646A (zh) 2020-06-09

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EP (2) EP4169539B1 (https=)
JP (3) JP2020525253A (https=)
KR (1) KR20200032103A (https=)
CN (1) CN111263646A (https=)
AU (2) AU2018290810C1 (https=)
CA (1) CA3068296A1 (https=)
CO (1) CO2020000774A2 (https=)
ES (2) ES2935887T3 (https=)
IL (2) IL299584A (https=)
MA (1) MA49520A (https=)
SG (1) SG11201913229PA (https=)
UA (1) UA127350C2 (https=)
WO (1) WO2019005848A1 (https=)

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CN113677320A (zh) * 2018-12-19 2021-11-19 自然进化公司 丝-透明质酸组织填充物及其制备和使用方法
CN114213517A (zh) * 2021-02-08 2022-03-22 复向丝泰医疗科技(苏州)有限公司 利用切向流超滤技术制备可控高浓度丝素蛋白溶液的方法
US11660372B2 (en) 2017-06-26 2023-05-30 Evolved By Nature, Inc. Silk-hyaluronic acid based tissue fillers and methods of using the same
CN116507315A (zh) * 2020-06-19 2023-07-28 自然进化公司 用于组织填充、组织间隔和组织膨胀的丝-透明质酸组合物
JP2024519426A (ja) * 2020-09-29 2024-05-14 ジロパ・インコーポレイテッド 疼痛の緩和及び麻痺のための組成物及び方法
US12611484B2 (en) 2023-04-25 2026-04-28 Evolved By Nature, Inc. Silk-hyaluronic acid based tissue filers and methods of using the same

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JP6508431B1 (ja) 2017-09-21 2019-05-08 住友電気工業株式会社 半絶縁性ヒ化ガリウム結晶基板
US20220193305A1 (en) * 2019-03-29 2022-06-23 Trustees Of Tufts College Crosslinked silk fibroin-based compositions, and methods of making and using the same
AU2020289479A1 (en) * 2019-06-06 2022-02-03 Evolved By Nature, Inc. Silk stimulated collagen production and methods of use thereof
WO2020262596A1 (en) * 2019-06-26 2020-12-30 Compagnie Generale Des Etablissements Michelin A noise improving tread
CN110339398A (zh) * 2019-07-18 2019-10-18 王月玲 一种含氨基酸透明质酸钠注射剂及其制备方法
EP4017537A4 (en) * 2019-08-20 2023-08-16 Evolved by Nature, Inc. SILK PERSONAL CARE PRODUCTS
EP3995530B1 (en) * 2019-09-27 2025-05-28 LG Chem, Ltd. A method of preparing polymer microparticles, polymer microparticles, medical composition, cosmetic composition, medical articles, and cosmetic articles using the same
PL4077402T3 (pl) * 2019-12-19 2024-07-29 Croma-Pharma Gmbh Kwas hialuronowy modyfikowany tiolem i hydrożel zawierający usieciowany kwas hialuronowy
US20250295691A1 (en) * 2020-06-19 2025-09-25 Evolved By Nature, Inc. Silk-Hyaluronic Acid Compositions For Tissue Filling, Tissue Spacing, and Tissue Bulking
TR202101065A1 (tr) * 2021-01-25 2022-08-22 Hacettepe Ueniversitesi Hyaluroni̇k asi̇t jel i̇çeren bi̇r doku dolgu malzemesi̇ ve üreti̇m yöntemi̇
JP7695344B2 (ja) 2021-05-21 2025-06-18 ケンブリッジ クロップス インコーポレイテッド． ドゥーイングビジネスアズ モリ 絹フィブロイン溶液及び絹フィブロインを含む粉末を製造するためのシステム及び方法
WO2023275278A1 (en) * 2021-06-30 2023-01-05 Merz Pharma Gmbh & Co. Kgaa Hyaluronic acid dermal fillers crosslinked with polyethylene glycol diglycidyl ether, method for making same and uses thereof
CN113368220A (zh) * 2021-07-05 2021-09-10 云南维他源生物科技有限公司 一种ahco组合物及其制剂与应用
KR20230013682A (ko) 2021-07-16 2023-01-27 주식회사 휴메딕스 Pegde로 가교된 히알루론산 필러 및 이의 제조방법
US11864569B2 (en) 2021-08-16 2024-01-09 Cambridge Crops, Inc. Systems and methods for improving the performance of cereal using a silk fibroin solution and powders containing silk fibroin
CN114028610B (zh) * 2021-10-26 2022-10-25 北京诺康达医药科技股份有限公司 一种亲水性注射型皮肤填充组合物及其制备方法与应用
KR102766244B1 (ko) * 2024-02-16 2025-02-10 충남대학교 산학협력단 Lc-ms/ms 기반의 히알루론산, bdde 및 bdde 가교된 히알루론산의 정량방법

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11660372B2 (en) 2017-06-26 2023-05-30 Evolved By Nature, Inc. Silk-hyaluronic acid based tissue fillers and methods of using the same
CN113677320A (zh) * 2018-12-19 2021-11-19 自然进化公司 丝-透明质酸组织填充物及其制备和使用方法
US12296067B2 (en) 2018-12-19 2025-05-13 Evolved By Nature, Inc. Silk-hyaluronic acid tissue fillers and methods of making and using the same
CN116507315A (zh) * 2020-06-19 2023-07-28 自然进化公司 用于组织填充、组织间隔和组织膨胀的丝-透明质酸组合物
JP2024519426A (ja) * 2020-09-29 2024-05-14 ジロパ・インコーポレイテッド 疼痛の緩和及び麻痺のための組成物及び方法
CN114213517A (zh) * 2021-02-08 2022-03-22 复向丝泰医疗科技(苏州)有限公司 利用切向流超滤技术制备可控高浓度丝素蛋白溶液的方法
US12611484B2 (en) 2023-04-25 2026-04-28 Evolved By Nature, Inc. Silk-hyaluronic acid based tissue filers and methods of using the same

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Publication number Publication date
JP2020525253A (ja) 2020-08-27
EP4169539A1 (en) 2023-04-26
AU2024219582A1 (en) 2024-10-03
ES2935887T3 (es) 2023-03-13
AU2018290810C1 (en) 2024-09-12
US20230338614A1 (en) 2023-10-26
UA127350C2 (uk) 2023-07-26
JP2025020289A (ja) 2025-02-12
EP3645063A4 (en) 2021-04-14
EP4169539B1 (en) 2025-01-29
EP4169539C0 (en) 2025-01-29
JP2023139249A (ja) 2023-10-03
WO2019005848A1 (en) 2019-01-03
KR20200032103A (ko) 2020-03-25
AU2018290810B2 (en) 2024-06-13
JP7660619B2 (ja) 2025-04-11
EP3645063A1 (en) 2020-05-06
CA3068296A1 (en) 2019-01-03
CO2020000774A2 (es) 2020-05-05
IL299584A (en) 2023-03-01
SG11201913229PA (en) 2020-01-30
IL271692B2 (en) 2023-06-01
ES3018883T3 (en) 2025-05-19
IL271692A (en) 2020-02-27
EP3645063B1 (en) 2022-09-28
MA49520A (fr) 2021-04-14
AU2018290810A1 (en) 2020-02-13
BR112019027687A2 (pt) 2020-09-15

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