CN111249363B

CN111249363B - A medicated liquor for treating rheumatoid arthritis, and preparation method thereof

Info

Publication number: CN111249363B
Application number: CN202010214699.7A
Authority: CN
Inventors: 李艺平
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-03-24
Filing date: 2020-03-24
Publication date: 2021-09-17
Anticipated expiration: 2040-03-24
Also published as: CN111249363A

Abstract

The invention provides medicinal liquor for treating rheumatoid arthritis and a preparation process thereof, and relates to the technical field of traditional Chinese medicines. The raw materials of the medicinal liquor comprise, by weight, 8-12 parts of angelica sinensis, 8-12 parts of red peony root, 8-12 parts of cassia twig, 4-8 parts of safflower, 8-12 parts of calcined pyrite, 8-12 parts of peach kernel, 6-10 parts of ground beeltle, 8-12 parts of achyranthes bidentata Blume, 8-12 parts of sardine, 3-7 parts of frankincense, 3-7 parts of myrrh and 8-12 parts of radix rehmanniae. The medicinal liquor obtained by soaking the raw materials in white spirit in a sealed manner has good curative effect on rheumatoid arthritis. And has high safety when used externally.

Description

A medicated liquor for treating rheumatoid arthritis, and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and in particular relates to medicinal liquor for treating rheumatoid arthritis and a preparation process thereof.

Background

Rheumatoid arthritis is one of the chronic diseases which are relatively common clinically, and the cause of the chronic diseases is unknown. Clinically, the arthritis is characterized by polyarticular, symmetrical and invasive joint inflammation of small joints of hands and feet and often accompanied by positive serum rheumatoid factor of extraarticular organs, which can cause joint deformity and function loss and mostly cause diseases with acute fever and joint pain. Western medicine is not a very effective treatment means at present, and mainly takes nonsteroidal anti-inflammatory drugs, slow-acting antirheumatic drugs, immunosuppressants, immune preparations, biological preparations and the like as medicinal treatment means. The above drugs have large side effects and are difficult to achieve good therapeutic effects. And the dosage is easy to increase due to the aggravation of the disease condition, thereby causing serious side effects.

According to the traditional Chinese medicine, the pathogenesis of rheumatoid arthritis is that pathogenic qi obstructs channels, namely pathogenic qi such as wind, cold, dampness, heat, phlegm and stasis are retained in the tendons, the joints, the muscles and the channels of limbs, and qi and blood obstruction is obstructed and causes pain. Pain and swelling in joints of bones and muscles can be caused by long-term arthralgia. At present, a plurality of traditional Chinese medicine compositions are used for treating rheumatoid arthritis, but most of the compositions are oral preparations, contain traditional Chinese medicine components with certain toxic effects such as kusnezoff monkshood root and the like, and still have larger potential risks after long-term administration.

Disclosure of Invention

The invention aims to provide medicinal liquor for treating rheumatoid arthritis, which has the effects of eliminating pathogenic factors, dredging collaterals, dispelling cold, dredging meridian, clearing and activating the channels and collaterals, nourishing blood and removing blood stasis, and has obvious curative effect when being externally applied to joints of patients.

The invention also aims to provide a preparation process of the medicinal liquor for treating rheumatoid arthritis, which adopts white spirit for multi-stage soaking.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

The invention provides a medicinal liquor for treating rheumatoid arthritis, which comprises, by weight, 8-12 parts of angelica sinensis, 8-12 parts of red peony root, 8-12 parts of cassia twig, 4-8 parts of safflower, 8-12 parts of calcined pyrite, 8-12 parts of peach kernel, 6-10 parts of ground beeltle, 8-12 parts of achyranthes bidentata Blume, 8-12 parts of sardine, 3-7 parts of frankincense, 3-7 parts of myrrh and 8-12 parts of radix rehmanniae.

Further, in a preferred embodiment, the Chinese angelica root is 9-11 parts, the red peony root is 9-11 parts, the cassia twig is 9-11 parts, the safflower is 5-7 parts, the calcined native copper is 9-11 parts, the peach kernel is 9-11 parts, the ground beetle is 7-9 parts, the achyranthes root is 9-11 parts, the sardine is 9-11 parts, the frankincense is 4-6 parts, the myrrh is 4-6 parts, and the radix rehmanniae is 9-11 parts.

Further, in a preferred embodiment, the Chinese angelica root is 10 parts, the red peony root is 10 parts, the cassia twig is 10 parts, the safflower is 6 parts, the calcined native copper is 10 parts, the peach kernel is 10 parts, the ground beetle is 8 parts, the bovine biliary powder is 10 parts, the rheum officinale is 10 parts, the frankincense is 5 parts, the myrrh is 5 parts, and the radix rehmanniae is 10 parts.

Further, in a preferred embodiment, the frankincense is vinegar processed frankincense, and the myrrh is vinegar processed myrrh.

The invention also provides a preparation process of the medicinal liquor for treating rheumatoid arthritis, which comprises the following steps:

s1, cutting the raw materials respectively and mixing to obtain a mixture;

s2, soaking the mixture in white wine according to the mass ratio of 1: 12-20, sealing for 6-10 days, and filtering to obtain a first wine liquid and a first medicine residue;

s3, grinding the first medicine residues, soaking the ground first medicine residues into white spirit according to the mass ratio of 1: 8-12, sealing for 4-6 days, and filtering to obtain second wine liquid and second medicine residues;

s4, soaking the second medicine residues in white spirit according to the mass ratio of 1: 4-8 after high-temperature and high-pressure treatment, sealing for 2-4 days, and filtering to obtain third wine liquid and third medicine residues;

s5, mixing the first wine liquid, the second wine liquid and the third wine liquid, and concentrating to obtain the medicinal liquor.

Further, in step S4 in a preferred embodiment, the high-temperature high-pressure processing step of the second medicine residue is: dispersing the second medicine residue in water, treating for 50-90 min at the temperature of 130-150 ℃ and under the pressure of 1.3-1.6 MPa, and concentrating to obtain a high-temperature high-pressure treatment substance of the second medicine residue.

Further, in a preferred embodiment, in the high-temperature high-pressure treatment step of the second dregs of decoction, the second dregs of decoction are dispersed in water according to a mass ratio of 1: 1.5-2.

Further, in a preferred embodiment, in the steps S2 to S4, the alcohol content of the white spirit used for soaking is 40 to 60 °.

Further, in a preferred embodiment, in the steps S2 to S4, before the white spirit is used, the white spirit is pre-bathed for 0.5 to 1 hour at 70 to 90 ℃.

Further, in a preferred embodiment, in step S5, the mixed wine is concentrated to 1/3-1/2 of the total volume after mixing.

The medicinal liquor for treating rheumatoid arthritis and the preparation process thereof have the advantages that:

the medicinal liquor for treating rheumatoid arthritis provided by the invention adopts various traditional Chinese medicinal materials, namely the Chinese angelica root, the ground beeltle, the calcined native copper, the achyranthes root and the rhubarb, can act on rheumatic ostealgia, has the effects of promoting blood circulation to remove blood stasis, dispelling wind and removing obstruction in channels, and relieving pain and swelling, and is used as a main medicament for smoothing channels and collaterals and dispelling dampness and toxicity. Radix Paeoniae Rubra, semen Persicae and radix rehmanniae have the effects of removing heat to cool blood and rheumatism, nourishing yin, removing blood stasis, moistening dryness and promoting fluid production, and are used as adjuvant drugs. The frankincense and myrrh are used as adjuvant medicines, and can dissipate blood stasis, relieve pain, promote tissue regeneration and reduce swelling. The safflower and the cassia twig are used as guiding drugs, can activate blood and dredge channels, warm and dredge channels and vessels, assist yang and transform qi, guide the drugs to the affected part and coordinate the drugs. The whole formula is compatible and used, has the effects of clearing heat and toxic materials, removing dampness and toxic materials, relieving pain and dissipating blood stasis, and clearing and activating the channels and collaterals, has good effects of relieving pain and swelling, and paralysis and the like caused by rheumatoid arthritis, and can effectively relieve symptoms in a short time. Meanwhile, the Chinese medicinal materials are soaked in the rice wine in a three-stage soaking mode, so that the functional components in the Chinese medicinal materials can be fully leached, and the curative effect is better. Moreover, the effect of warming, dredging and dispersing the white spirit can be utilized, the efficacy of the medicine can be better dispersed, and the treatment effect can be improved.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

Fig. 1 is a flow chart of a manufacturing process of a medicinal liquor for treating rheumatoid arthritis according to an embodiment of the invention;

FIG. 2 is a photograph of the affected part before treatment in typical case 4;

fig. 3 is a photograph of the affected part after treatment of typical case 4.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

The following is a detailed description of the medicated wine for treating rheumatoid arthritis and the manufacturing process thereof according to the embodiment of the present invention.

Radix Angelicae sinensis is the dried root of Angelica sinensis (oliv.) Diels of Umbelliferae. It is used for treating blood deficiency; menoxenia; amenorrhea; dysmenorrhea; mass; (ii) metrorrhagia and metrostaxis; abdominal pain due to deficiency-cold; flaccidity and paralysis; numbness of the skin; intestinal dryness and difficult defecation; severe dysentery with diarrhea; carbuncle, cellulitis, sore and ulcer; injury from falling.

The radix Paeoniae Rubra is dried root of Paeonia lactiflora pall or Paeonia veitchii Schott of Ranunculaceae. Has the effects of clearing heat, cooling blood, promoting blood circulation and removing blood stasis.

Ramulus Cinnamomi has effects of inducing sweat, expelling pathogenic factors from muscles, warming and dredging channels, tonifying yang, regulating qi, and calming the adverse-rising energy.

Carthami flos is dried flower of Carthamus tinctorius L of Compositae, and has effects of promoting blood circulation, dredging channels, removing blood stasis, and relieving pain.

The calcined pyrite is pyrite which is a sulfide iron ore group mineral and contains iron disulfide, namely pith lead and copper cubes. Has effects in dispelling blood stasis, relieving pain, and promoting reunion of fractured bones. In this example, the process for preparing calcined Pyritum is as follows: calcining natural copper blocks till the copper blocks are red completely, and pouring the calcined natural copper blocks into rice vinegar for quenching and crisp. Then taking out, calcining again, adding rice vinegar to quench and crisp once, and repeating the process until the luster disappears. Then the calcined pyrite is obtained after being dried in the sun and ground into coarse powder.

Semen Persicae is dry mature seed of Prunus persica or Prunus davidiana of Rosaceae, and has effects of promoting blood circulation, removing blood stasis, loosening bowel to relieve constipation, and relieving cough and asthma.

The Eupolyphaga Seu Steleophaga is female dry body of Eupolyphaga Seu Steleophaga or Eupolyphaga Seu Steleophaga of Cyperaceae. Has effects of removing blood stasis, promoting reunion of fractured tendons and bones.

Niu Qi is also called Duoyougong and June Xue, and is the root of Jazz plant Callicarpa Longissima. Has effects of dispelling pathogenic wind, dredging collaterals, removing blood stasis, relieving pain, and eliminating carbuncle and swelling.

The rhubarb, named as Shuhua Weimao, has the functions of promoting blood circulation, eliminating blood stasis, relieving pain and diminishing inflammation. Has the functions of dispelling wind-damp; strengthening bones and muscles; promoting blood circulation and removing toxic substances; the action of inducing diuresis.

The Olibanum is oleoresin exuded from bark of Ruxiang tree, Bowda serrata, and Yelloxiang tree of Burseraceae. Has effects in promoting blood circulation, activating qi-flowing, dredging channels, relieving pain, eliminating swelling, and promoting granulation. Myrrha, also called powder medicine, is dried resin of Diding tree or Hadi tree of Burseraceae. Has effects in removing blood stasis, relieving pain, eliminating swelling, and promoting granulation. Further, the frankincense used in this example is vinegar-processed frankincense, and the myrrh used is vinegar-processed myrrh. The steps of preparing frankincense by vinegar are as follows: putting clean Olibanum in a pan, parching with slow fire until the surface is slightly melted, spraying rice vinegar, and parching until the surface is oily and glossy. The weight ratio of the frankincense to the rice vinegar is 20: 0.5-1.5. The preparation of myrrh with vinegar is carried out in the same way as the preparation of frankincense with vinegar. The vinegar-processed frankincense and the vinegar-processed myrrh can exert the efficacy of the medicine better and have better effects of clearing and activating the channels and collaterals.

The raw rehmannia root is also called raw rehmannia root, wild rehmannia root, mountain tobacco root and the like, and is the root tuber of rehmannia root of Scrophulariaceae. It is sweet and bitter in taste and cold in nature and enters blood system, and can clear heat in nutrient and blood systems to cool blood. And the moistening multi-fluid can nourish yin, the sweet taste and the cold nature can promote the production of body fluid, and the moistening dryness can promote the production of body fluid.

The raw materials are used together, so that the effects of clearing heat and toxic materials, removing dampness and toxic materials, relieving pain and removing blood stasis and clearing and activating the channels and collaterals are achieved, the effect of treating both symptoms and root causes of the rheumatoid arthritis is achieved, joint swelling and pain, paralysis and the like caused by the rheumatoid arthritis are effectively relieved, and the treatment course is short.

Further, in a preferred embodiment, the Chinese angelica root is 10 parts, the red peony root is 10 parts, the cassia twig is 10 parts, the safflower is 6 parts, the calcined native copper is 10 parts, the peach kernel is 10 parts, the ground beetle is 8 parts, the bovine biliary powder is 10 parts, the rheum officinale is 10 parts, the frankincense is 5 parts, the myrrh is 5 parts, and the radix rehmanniae is 10 parts. Through meticulous blending to each medicinal material proportion, under this formula proportion, obtain the best treatment.

The embodiment of the invention also provides a preparation process of the medicinal liquor for treating rheumatoid arthritis, which comprises the following steps:

s1, cutting the above raw materials, and mixing to obtain a mixture.

And S2, soaking the mixture obtained in the step S1 in white spirit according to the mass ratio of 1: 12-20, sealing for 6-10 days, and filtering to obtain a first wine liquid and a first medicine residue.

And S3, grinding the first medicine residue obtained in the step S2, soaking the ground first medicine residue in white spirit according to the mass ratio of 1: 8-12, sealing the white spirit for 4-6 days, and filtering the white spirit to obtain a second wine liquid and second medicine residue. And (3) putting the first decoction dregs obtained after the first stage of soaking into milling equipment, milling the first decoction dregs to be finer, and destroying the structure of the medicinal materials so as to be convenient for the ingredients which are not dissolved out to be continuously dissolved out.

And S4, performing high-temperature high-pressure treatment on the second medicine residue obtained in the step S3, soaking the second medicine residue in white spirit according to the mass ratio of 1: 4-8, sealing for 2-4 days, and filtering to obtain third wine liquid and third medicine residue.

Further, in a preferred embodiment, the high-temperature high-pressure treatment step of the second herb residue comprises: dispersing the second medicine residue in water, treating for 50-90 min at the temperature of 130-150 ℃ and under the pressure of 1.3-1.6 MPa, and concentrating to obtain a high-temperature high-pressure treatment substance of the second medicine residue. More preferably, the second dregs of a decoction are dispersed in water according to the mass ratio of 1: 1.5-2. Through carrying out hydrolysis treatment on the second medicine dregs under the conditions of certain temperature and pressure, cellulose structures in partial medicinal materials can be damaged and softened, the internal tissue structure of the material is further damaged, more effective components are exposed, the subsequent dip-dyeing of white spirit is facilitated, and the active components of the raw materials are efficiently leached. The utilization rate of raw materials is higher, and the effect is stronger.

S5, mixing the first wine liquid obtained in S2, the second wine liquid obtained in S3 and the third wine liquid obtained in S4, and concentrating to obtain the medicated wine. Further preferably, the mixed liquor is concentrated to 1/3-1/2 of the total volume after mixing. The wine liquid obtained by soaking in sections is concentrated, so that the drug effect in the medicinal wine per unit volume is ensured to reach a certain degree, and the treatment process is accelerated.

Further, in a preferred embodiment, the alcohol content of the white spirit used for soaking in the steps S2-S4 is 40-60 °.

Further, in a preferred embodiment, the white spirit used for soaking in steps S2-S4 is pre-soaked in water at 70-90 ℃ for 0.5-1 h before use. The Chinese liquor is heated in advance, so that the medicinal materials have stronger penetrating power when being soaked, and the replacement and diffusion are promoted.

Further, in a preferred embodiment, in steps S2 to S4, an auxiliary agent is added to the white spirit for soaking in advance in an amount of 2 to 5 mass% before soaking, wherein the auxiliary agent includes menthol and butanediol in a mass ratio of 1:1 to 2. The addition of menthol and butanediol can remove foams generated in the preparation process of the medicinal liquor without influencing the medicinal effect of the medicinal liquor. On the other hand, the menthol and the butanediol are compounded for use, so that the penetration of drug effect components to the skin can be remarkably promoted, the protection is formed on the surface of the skin, after the medicinal liquor is externally applied to an affected part, the drug effect quickly penetrates into the skin, the medicinal liquor plays a role in a short time, and the curative effect is reduced due to the surface volatilization on the surface.

The use mode of the medicinal liquor provided by the embodiment of the invention is external application. Specifically, the medicinal liquor is applied to the affected part, wrapped with medical gauze, and placed in a hot water bag for hot compress.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

This example provides a medicated wine for treating rheumatoid arthritis, made according to the following steps:

(1) preparing raw materials in proportion: 10 parts of angelica tail, 10 parts of red paeony root, 10 parts of cassia twig, 6 parts of safflower, 10 parts of calcined pyrite, 10 parts of peach kernel, 8 parts of ground beetle, 10 parts of achyranthes root, 10 parts of rhubarb, 5 parts of frankincense, 5 parts of myrrh and 10 parts of radix rehmanniae. Cutting the raw materials respectively and mixing to obtain a mixture.

(2) Soaking the mixture obtained in the step (1) in 55-degree white spirit according to the mass ratio of 1:15, sealing for 8 days, and filtering to obtain liquor A and herb residue A.

(3) Grinding the medicine residue A obtained in the step (2), soaking the medicine residue A in 55-degree white spirit according to the mass ratio of 1:10, sealing for 5 days, and filtering to obtain a wine liquid B and medicine residue B.

(4) Dispersing the residue B obtained in (3) in 2 times of water, and treating at 140 deg.C under 1.5MPa for 60 min. Soaking the processed product in 55 ° Chinese liquor at a mass ratio of 1:6, sealing for 3 days, and filtering to obtain liquor C and residue C.

(5) Mixing the liquor A, liquor B and liquor C, and concentrating to 1/3 of the total volume of the mixture to obtain the medicated liquor.

Example 2

(1) preparing raw materials in proportion: 8 parts of angelica tail, 12 parts of red paeony root, 8 parts of cassia twig, 8 parts of safflower, 8 parts of calcined pyrite, 12 parts of peach kernel, 6 parts of ground beeltle, 12 parts of achyranthes root, 8 parts of sardine, 7 parts of frankincense, 3 parts of myrrh and 12 parts of radix rehmanniae. Cutting the raw materials respectively and mixing to obtain a mixture.

Example 3

(1) preparing raw materials in proportion: 12 parts of angelica tail, 8 parts of red paeony root, 12 parts of cassia twig, 4 parts of safflower, 12 parts of calcined pyrite, 8 parts of peach kernel, 10 parts of ground beeltle, 8 parts of achyranthes root, 12 parts of sardine, 3 parts of frankincense, 7 parts of myrrh and 8 parts of radix rehmanniae. Cutting the raw materials respectively and mixing to obtain a mixture.

Example 4

(2) And (3) carrying out water bath on 55-degree white spirit at 80 ℃ for 40min, and then soaking the mixture obtained in the step (1) in a mass ratio of 1: 15. Sealing at room temperature for 8 days, and filtering to obtain liquor A and residue A.

(3) Soaking 55-degree white spirit in water at 80 deg.C for 40min, grinding the residue A obtained in step (2), and soaking in the ground residue A at a mass ratio of 1: 10. Sealing at room temperature for 5 days, and filtering to obtain liquor B and residue B.

(4) Dispersing the residue B obtained in (3) in 2 times of water, and treating at 140 deg.C under 1.5MPa for 60 min. Soaking 55-degree Chinese liquor in water at 80 deg.C for 40min, soaking the processed product in the water at a mass ratio of 1:6, sealing at room temperature for 3 days, and filtering to obtain liquor C and residue C.

Example 5

This example provides a medicated wine for treating rheumatoid arthritis, which is different from example 4 in that the white spirit in steps (2) to (4) each contains 1.5 wt% of menthol and 1.5 wt% of butylene glycol.

Comparative example 1

The present comparative example provides a medicated wine for treating rheumatoid arthritis, prepared according to the following steps:

(4) And (4) soaking the medicine residue B obtained in the step (3) in 55-degree white spirit according to the mass ratio of 1:6, sealing for 3 days, and filtering to obtain a wine liquid C and medicine residue C.

Test example 1

90 rheumatoid arthritis patients aged 40-70 years were selected and had comparable degrees of disease. Wherein each 30 male and female patients are divided into three groups, each group comprises 30 patients and halves of male and female patients, and the average age of each group is not more than 5 years old. Each group of patients was subjected to daily hot compress for 40min before sleep using the medicated liquors provided in example 1, example 5 and comparative example 1, respectively. The treatment conditions are shown in table 1.

TABLE 1

Group of	Number of examples	15 days improvement/example	30 days improvement/example	45 days improvement/example	Without any improvement/example
						Example 1	30	2	14	9	5
Example 5	30	8	16	4	2
						Comparative example 1	30	0	6	13	11

Typical case 1

Some forest, male, age 42. According to the diagnosis of rheumatoid arthritis in the municipal hospitals, the knee joint, namely the lower leg bone, can cause ache, carbuncle and swelling due to weather change, and the person can fall asleep by pressing a heavy object on the lower leg. The disease is affected for 3 years. The medicated wine prepared in the embodiment 1 of the invention is used for hot compress for 30-50 min before sleeping every day. After 30 days, the sore condition substantially heals. After 5 months of follow-up, no recurrence was observed.

Typical case 2

Chuanyao, male, 65 years old. In young, the knee joint is injured by over-impact, and is diagnosed as rheumatoid arthritis by a municipal hospital. Cramp symptoms can appear when people walk, and the people feel hard to feel sore when going down and up a slope. After the patient suffers from the disease for 3 years, the medicinal liquor prepared in the embodiment 4 of the invention is used for hot compress for 30-50 min before sleeping every day. After lasting for 15 days, cramps and soreness are obviously improved, and after lasting for 45 days, the disease is basically cured. After 4 months of follow-up, no recurrence was observed.

Typical case 3

Old somebody, male, age 41. The patients are diagnosed as rheumatoid arthritis and right elbow joint ache by a municipal hospital, and are inconvenient to bend and stretch and ill for 4 years. The medicated wine prepared in the embodiment 5 of the invention is used for hot compress for 30-50 min before sleeping every day. After lasting for 5 days, the ache condition is obviously improved, and after lasting for 15 days, the ache condition is basically cured. After 4 months of follow-up, no recurrence was observed.

Typical case 4

Some in forest, female, 53 years old. Rheumatoid knee arthritis, knee carbuncle and swelling, walking soreness and mobility difficulty. The disease is 4 years old. The medicated wine prepared in the embodiment 2 of the invention is used for hot compress for 30-50 min before sleeping every day. After lasting for 15 days, the ache is improved, and after lasting for 50 days, the ache is basically cured. After 5 months of follow-up, no recurrence was observed. Fig. 2 shows a photograph of the affected part before treatment, and fig. 3 shows a photograph of the affected part after treatment. It is seen that after treatment, the swollen carbuncle on the knee clearly disappeared.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. A medicinal liquor for treating rheumatoid arthritis by hot compress is characterized by comprising the following raw materials in parts by weight: 8-12 parts of angelica tail, 8-12 parts of red peony root, 8-12 parts of cassia twig, 4-8 parts of safflower, 8-12 parts of calcined pyrite, 8-12 parts of peach kernel, 6-10 parts of ground beetle, 8-12 parts of achyranthes root, 8-12 parts of rhubarb, 3-7 parts of frankincense, 3-7 parts of myrrh and 8-12 parts of radix rehmanniae;

wherein the radix Achyranthis is root of Callicarpa Longissima of Acanthaceae.

2. The medicated wine according to claim 1, wherein the angelica tails account for 9-11 parts, the red peony roots account for 9-11 parts, the cassia twig accounts for 9-11 parts, the safflower accounts for 5-7 parts, the calcined native copper accounts for 9-11 parts, the peach kernels account for 9-11 parts, the ground beeltles account for 7-9 parts, the achyranthes bidentata accounts for 9-11 parts, the rheum officinale accounts for 9-11 parts, the frankincense accounts for 4-6 parts, the myrrh accounts for 4-6 parts, and the radix rehmanniae accounts for 9-11 parts.

3. The medicated wine of claim 1, wherein the radix Angelicae sinensis is 10 parts, the radix Paeoniae Rubra is 10 parts, the ramulus Cinnamomi is 10 parts, the flos Carthami is 6 parts, the calcined Pyritum is 10 parts, the semen Persicae is 10 parts, the Eupolyphaga Seu Steleophaga is 8 parts, the calculus bovis is 10 parts, the herba Sarcandrae is 10 parts, the Olibanum is 5 parts, the Myrrha is 5 parts, and the radix rehmanniae is 10 parts.

4. The medicated wine of claim 1, wherein the olibanum is vinegar-processed olibanum, and the myrrh is vinegar-processed myrrh.

5. The preparation method of the medicinal liquor according to any one of claims 1 to 4, which is characterized by comprising the following steps:

s1, cutting the raw materials respectively and mixing to obtain a mixture;

s5, mixing the first wine liquid, the second wine liquid and the third wine liquid, and concentrating to obtain the medicinal liquor;

in step S4, the high-temperature high-pressure treatment step of the second medicine residue includes: dispersing the second medicine residue in water, treating for 50-90 min at the temperature of 130-150 ℃ and the pressure of 1.3-1.6 MPa, and concentrating to obtain a high-temperature high-pressure treatment substance of the second medicine residue;

in the steps S2-S4, before the white spirit is used, the white spirit is pre-bathed for 0.5-1 hour at the temperature of 70-90 ℃.

6. The preparation method according to claim 5, wherein in the high-temperature high-pressure treatment step of the second herb residue, the second herb residue is dispersed in water in a mass ratio of 1: 1.5-2.

7. The preparation method according to claim 5, wherein the alcohol content of the white spirit used for soaking in the steps S2-S4 is 40-60 °.

8. The method according to claim 5, wherein in step S5, the mixed liquor is concentrated to 1/3-1/2 of the total volume after mixing.