CN111228646A - Electronic treatment system, electronic device comprising same, synchronization method and storage medium - Google Patents

Electronic treatment system, electronic device comprising same, synchronization method and storage medium Download PDF

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Publication number
CN111228646A
CN111228646A CN202010014295.3A CN202010014295A CN111228646A CN 111228646 A CN111228646 A CN 111228646A CN 202010014295 A CN202010014295 A CN 202010014295A CN 111228646 A CN111228646 A CN 111228646A
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electronic device
time
electronic
vivo
stimulation
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CN111228646B (en
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胥红来
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Neuracle Technology Changzhou Co ltd
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Neuracle Technology Changzhou Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0022—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the tactile sense, e.g. vibrations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0027—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0044—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the sight sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3507—Communication with implanted devices, e.g. external control
    • A61M2205/3523—Communication with implanted devices, e.g. external control using telemetric means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3569—Range sublocal, e.g. between console and disposable

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Abstract

The invention provides an electronic treatment system, an electronic device, a synchronization method and a storage medium, and relates to the technical field of electronic medical treatment. The electronic therapy system includes an extracorporeal electronic device and at least one in-vivo electronic device, each of the at least one in-vivo electronic device being electrically connected to at least one electrode disposed within a patient, and the synchronization method includes: acquiring timestamp offset of each electronic device; and realizing the time synchronization of the electronic devices according to the respective timestamp offsets of the electronic devices. The time stamp offset of different electronic devices is adopted in the time synchronization process, so that the error caused by the time stamp difference in the traditional synchronization mode can be solved, the time synchronization precision can be improved, the requirement of data processing of a medical system on the time precision can be particularly met, the accuracy of clinical judgment reference can be ensured, and the cooperative work of acquisition, stimulation, administration and the like of each electronic device is realized.

Description

Electronic treatment system, electronic device comprising same, synchronization method and storage medium
Technical Field
The present invention relates to the field of electronic medical technology, and in particular, to an electronic treatment system, electronic devices included in the electronic treatment system, a method for time synchronization between the electronic devices, and a computer-readable storage medium.
Background
Various medical devices implanted into a human body are buried in bones or cavity tissues of various parts of the human body, and include a collector capable of collecting bioelectricity of the corresponding part of the human body and a stimulator capable of applying a stimulus having an appropriate intensity to the various parts of the human body.
The complexity of the electronic systems implanted in the body has increased in recent years, and the requirements for multiple in vivo implanted electronic devices or the cooperation of an in vivo implanted electronic device with an in vitro electronic device have become higher and higher.
Unlike in vitro electronic devices, in vivo implanted electronic devices typically use wireless means for control and data transmission. The traditional in-vivo implanted electronic devices often work independently, and the control signal or the acquisition signal of each in-vivo implanted electronic device cannot be accurately synchronized with the wireless signals of other in-vivo implanted electronic devices or in-vitro electronic devices. In order to improve the diagnosis accuracy and work efficiency of diseases, doctors often need to more accurately grasp the activity states of different treatment parts of patients in the same time period (point) and the corresponding physiological electrical signal changes, which requires to synchronously compare and analyze the cooperative work data of a plurality of electronic devices.
In such a scenario, it is necessary to acquire, stimulate, and administer drugs to multiple sites simultaneously. For example, the judgment of physiological electric signals needs to be based on signals of different parts together; also, stimulation and administration require an assessment and treatment based on the overall physiological condition.
However, conventionally, the time stamps of the electronic apparatuses are recorded or cleared respectively when the electronic apparatuses are started, and then data synchronization is performed according to the time stamps, but due to a series of circuit characteristic differences such as operating clocks/frequencies of different electronic apparatuses, the time stamp differences of signals of a plurality of devices are gradually increased when the electronic apparatuses cooperatively operate, so that the time synchronization accuracy is reduced, and the accuracy requirement for the time synchronization under the above-mentioned scenario cannot be met.
Therefore, there is a need in the art for a time synchronization method to achieve time synchronization of different electronic devices in an electronic therapy system.
Disclosure of Invention
In order to solve the technical problems in the prior art, embodiments of the present invention provide an electronic treatment system, an electronic device included in the electronic treatment system, and a time synchronization method between the electronic devices, so as to implement synchronization of multiple electronic devices, and implement cooperative collection, stimulation, administration, and other operations of each electronic device.
According to a first aspect of the present invention, an embodiment of the present invention provides an electronic therapy system, which includes:
at least one in-vivo electronic device adapted to be disposed within a body of a patient, each of the at least one in-vivo electronic device being electrically connected to at least one electrode disposed within the body of the patient through which data of a physiological electrical signal of the patient is acquired or to which a stimulation signal is sent;
an extracorporeal electronic device adapted to be disposed outside the patient's body, wirelessly connected with the at least one in-vivo electronic device; and
the main control device is suitable for being arranged outside the body of a patient and is in wired or wireless connection with the in-vitro electronic device, and is used for controlling and processing data of the in-vivo electronic device and the in-vitro electronic device;
wherein, the main control device controls and processes the data of the in vivo implanted electronic device and the in vitro electronic device, and comprises: time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device is achieved according to a timestamp offset of the respective electronic device.
In one embodiment of the invention, the timing is based on a timestamp offset of each of the at least one in-vivo electronic device and the in-vitro electronic device to achieve time synchronization of the respective electronic devices.
In an embodiment of the present invention, the master control device implementing time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device according to a timestamp offset of each of the at least one in-vivo electronic device and the in-vitro electronic device includes:
selecting a time axis of any one of the electronic devices as baseline time;
and adding the difference between the timestamp offset of each of the other electronic devices in each electronic device and the timestamp offset of the electronic device corresponding to the baseline time (namely, the timestamp offset of the other electronic devices relative to the electronic device serving as the baseline) by taking the baseline time as a reference to obtain the data collected by the other electronic devices or the actual time for sending the stimulation.
In another embodiment of the present invention, the master control device implementing time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device according to a timestamp offset of each of the at least one in-vivo electronic device and the in-vitro electronic device comprises:
the master control device sends out a synchronous signal to each electronic device;
each electronic device clears the self timestamp offset after receiving the synchronization signal, and the cleared timestamp offset begins to synchronously and automatically increase along with the running time;
the main control device receives the timestamp offset of each electronic device;
and the master control device takes the time axis of any one of the electronic devices as a time base line, and aligns the time for acquiring data or the time for sending stimulation according to the respective timestamp offset of each in-vivo electronic device.
The master control device may send a synchronization signal to each electronic device at a predetermined time interval. Alternatively, the predetermined time interval may be 10 seconds to 200 seconds.
In another embodiment of the present invention, the controlling and processing the data of the in-vivo implanted electronic device and the in-vitro electronic device by the master control device may further include: and storing and/or displaying the acquired data after time synchronization.
In some embodiments of the present invention, the controlling and processing data of the in-vivo implanted electronic device and the in-vitro electronic device by the master control device further comprises:
generating a stimulation command or selecting a predefined stimulation command according to the acquired data;
transmitting the stimulation command to one or more of the at least one in-vivo electronic device and an in-vitro electronic device.
Wherein the in vivo implanted electronic device receiving the stimulation command can generate a stimulation signal according to the stimulation command and send the stimulation signal to the corresponding electrode. Alternatively or additionally, the external electronics receiving the stimulation command may send external stimulation to the patient at a synchronized time. Wherein the in vitro stimulation may include auditory stimulation, visual stimulation, tactile stimulation, and the like.
In an alternative embodiment of the invention, the master control device and the extracorporeal electronic device may be integrated on a single apparatus. In other words, the above-described processes of the main control apparatus and the extracorporeal electronic apparatus may be collectively performed by a single computing device.
According to a second aspect of the present invention, an embodiment of the present invention provides a control device for use in an electronic therapy system, comprising:
a communication interface for communicating with at least one in-vivo electronic device implanted in a patient via an in-vitro electronic device connected thereto;
a memory having computer instructions stored thereon;
a processor for executing the computer instructions to perform the following operations: time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device is achieved according to a timestamp offset of the respective electronic device.
In one embodiment of the invention, the processor executing the computer instructions to achieve time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device according to a timestamp offset of the respective electronic device comprises:
selecting a time axis of any one of the electronic devices as baseline time; and adding the difference between the timestamp offset of each of the other electronic devices in each electronic device and the timestamp offset of the electronic device corresponding to the baseline time by taking the baseline time as a reference to obtain the actual time for acquiring data or sending stimulation by the other electronic devices.
In another embodiment of the present invention, the processor executing the computer instructions to achieve time synchronization of respective ones of the at least one in-vivo electronic device and the in-vitro electronic device according to timestamp offsets of the respective electronic devices comprises:
the processor executes the computer instructions to perform operations comprising:
sending a synchronization signal to each electronic device, wherein each electronic device clears the timestamp offset of the electronic device after receiving the synchronization signal, and the cleared timestamp offset begins to synchronously and automatically increase along with the running time;
the main control device receives the timestamp offset of each electronic device;
and the master control device takes the time axis of any one of the electronic devices as a time base line, and aligns the time for acquiring data or the time for sending stimulation according to the respective timestamp offset of each in-vivo electronic device.
In some embodiments of the invention, the processor executes the computer instructions to perform operations to achieve time synchronization of respective ones of the at least one in-vivo electronic device and the in-vitro electronic device according to timestamp offsets of the respective electronic devices at predetermined time intervals. For example, the predetermined time interval may include 10 seconds to 200 seconds.
In some embodiments of the invention, the processor executes the computer instructions to store the synchronized collected data in the memory or other storage device. Optionally, the control device further includes a display, wherein the processor executes the computer instructions to display the synchronized collected data through the display.
In other embodiments of the invention, the processor executes the computer instructions to perform the following operations:
generating a stimulation command or selecting a predefined stimulation command according to the acquired data;
sending the stimulation command to one or more of the at least one in vivo implanted electronic device and an in vitro electronic device.
According to a third aspect of the present invention, embodiments of the present invention provide an in vivo electronic device adapted to be implanted in a patient, comprising:
a communication interface for communicating with a control device via an in vitro electronic device wirelessly connected thereto or with the control device via a wireless connection;
a memory having computer instructions stored thereon;
a processor for executing the computer instructions to send the acquired data acquired via the electrodes of the physiological condition in the patient's body and the timestamp offsets to the control device, such that the control device can time synchronize with other electronic devices based on the timestamp offsets, e.g., such that the control device can synchronize the acquired data from each in-vivo electronic device with the timestamp offsets of other in-vivo electronic devices based on the timestamp offsets.
In one embodiment of the invention, the processor executes the computer instructions to:
according to the received synchronization signal from the control device, the self timestamp offset is cleared, and the cleared timestamp offset begins to synchronously and automatically increase along with the running time;
and sending the acquired data acquired by the electrode and the timestamp offset to the control device through the communication interface.
In another embodiment of the present invention, the processor executing the computer instructions further performs the following operations:
and generating a stimulation signal according to the stimulation command received by the communication interface from the control device, and sending the stimulation signal to the corresponding electrode.
According to a fourth aspect of the present invention, an embodiment of the present invention provides an in vitro electronic device, comprising:
a communication interface that communicates with the in-vivo electronic device through a wireless connection and communicates with the control device through a wireless connection or a wired connection;
a memory having computer instructions stored thereon;
a processor for executing the computer instructions to send a timestamp offset to the control device, such that the control device can achieve time synchronization according to the timestamp offset and a timestamp offset of the in-vivo electronic device.
In one embodiment of the invention, the processor executes the computer instructions to:
according to the received synchronization signal from the control device, the self timestamp offset is cleared, and the cleared timestamp offset begins to synchronously and automatically increase along with the running time;
and sending the timestamp offset of the in-vivo electronic device and the timestamp offset from the in-vivo electronic device to the control device through the communication interface.
In one embodiment of the invention, the processor executes the computer instructions to:
sending an extracorporeal stimulation to the patient according to the stimulation command received by the communication interface from the control device. Optionally, the in vitro stimulation comprises auditory stimulation, visual stimulation, tactile stimulation, or the like.
According to a fifth aspect of the present invention, embodiments of the present invention provide a method for time synchronization of an electronic therapy system, wherein the electronic therapy system comprises an extracorporeal electronic device and at least one in-vivo electronic device, each of the at least one in-vivo electronic device being electrically connected to at least one electrode arranged inside a patient's body, and the method comprises:
obtaining a timestamp offset for each of the at least one in-vivo electronic device and the in-vitro electronic device;
and realizing the time synchronization of the electronic devices according to the respective timestamp offsets of the electronic devices.
In one embodiment of the present invention, the time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device according to the timestamp offset of each of the electronic devices comprises:
selecting a time axis of any one of the electronic devices as baseline time;
and adding the difference between the timestamp offset of each of the other electronic devices in each electronic device and the timestamp offset of the electronic device corresponding to the baseline time by taking the baseline time as a reference to obtain the actual time for acquiring data or sending stimulation by the other electronic devices.
In one embodiment of the invention, the method further comprises:
and before the timestamp offsets of the electronic devices are acquired, sending a synchronization signal for clearing the timestamp offsets of the electronic devices to the electronic devices, wherein the cleared timestamp offsets begin to increase automatically along with the running time.
Wherein the time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device according to the timestamp offset of each of the electronic devices may comprise: and aligning the time for acquiring data or the time for sending the stimulation according to the respective timestamp offsets of the in-vivo electronic devices by taking the time axis of any one of the electronic devices as a time base line.
Alternatively, the steps of the method may be performed at predetermined time intervals. Wherein the predetermined time interval may include 10 seconds to 200 seconds.
According to a sixth aspect of the present invention, embodiments of the present invention provide a computer-readable storage medium having stored thereon computer instructions, which, when executed by a processor, implement the method, operation, process or steps of any one of the above-mentioned embodiments.
The implementation of the invention can achieve the following beneficial effects:
according to various embodiments of the invention, time synchronization among the electronic devices is realized through timestamp offset of each electronic device, and timestamp change, namely offset, of different electronic devices is considered in the synchronization process, so that errors caused by timestamp difference in the traditional synchronization mode can be solved, the precision of time synchronization can be improved, the requirements of data processing on time precision in the electronic medical field can be particularly met, the accuracy of clinical judgment reference is ensured, and cooperative work of acquisition, stimulation, administration and the like of each electronic device is realized.
The time synchronization of the in-vivo electronic device and the in-vitro electronic device can realize the synchronization of the sending time of the in-vitro stimulation and the acquisition time of the data of the in-vivo physiological electric signals.
By using the time synchronization technique of the present invention, multiple in vivo electronic devices can be implanted at different sites in the body to simultaneously harvest/stimulate different sites. Therefore, the following technical problems existing in the prior art that one implantation device is adopted to tap out a connecting wire for simultaneously collecting/stimulating different parts can be avoided:
1) the connecting wire needs to be fixed in the cranium, so that the surgical trauma range is increased;
2) signals are easily interfered in the transmission process of the connecting line, so that the analysis accuracy is influenced;
3) the implanted electronic device is limited by a battery and power, generally, one implanted device only supports two external connecting wires, and in this case, the power which can support data acquisition and stimulation or drug delivery on each connecting wire is 1/2 of the maximum power;
4) if the two collection, stimulation or administration sites are too far apart, this cannot be achieved with one implant device.
In summary, in the electronic treatment system using the time synchronization method of the present invention, in addition to solving the problem of the decreased time synchronization precision of the conventional synchronization method, different in vivo electronic devices can be implanted into different parts, thereby further solving the four technical problems caused by the fact that one existing implantation device is connected to different connecting lines, and realizing the simultaneous data acquisition and stimulation of different parts.
Drawings
Fig. 1 is a block diagram of an electronic therapy system according to an exemplary embodiment of the present invention.
Fig. 2 is a flow chart of time synchronization in the system shown in fig. 1.
Fig. 3 is a block diagram of an electronic therapy system in accordance with another embodiment of the present invention.
Fig. 4 is a flowchart of a method for time synchronization for an electronic therapy system according to an exemplary embodiment of the present invention.
Fig. 5 is a flowchart of a method for time synchronization for an electronic therapy system according to another exemplary embodiment of the present invention.
Fig. 6 is a block diagram of a control device for use in an electronic therapy system according to an exemplary embodiment of the present invention.
FIG. 7 is a block diagram of an in-vivo electronic device adapted to be implanted in a patient according to an exemplary embodiment of the invention.
Fig. 8 is a block diagram of an extracorporeal electronic device according to an exemplary embodiment of the present invention.
Detailed Description
Various aspects of the invention are described in detail below with reference to the figures and the detailed description. Well-known modules, units and their interconnections, links, communications or operations with each other are not shown or described in detail. Furthermore, the described features, architectures, or functions can be combined in any manner in one or more implementations. It will be understood by those skilled in the art that the various embodiments described below are illustrative only and are not intended to limit the scope of the present invention. It will also be readily understood that the modules or units or processes of the embodiments described herein and illustrated in the figures can be combined and designed in a wide variety of different configurations.
Fig. 1 is a block diagram of an electronic therapy system according to an exemplary embodiment of the present invention. In an exemplary embodiment of the present invention, the electronic therapy system may include a main control device 100, an extracorporeal electronic device 200, and a plurality of in-vivo electronic devices (including a first in-vivo electronic device 301 and a second in-vivo electronic device 302). Wherein the plurality of in vivo electronic devices are respectively connected with the electrodes and are arranged at different sites in the body of the patient, facilitating simultaneous acquisition or stimulation of different sites. In this embodiment, the first in-body electronic device 301 is electrically connected to the electrode 401, and the second in-body electronic device 302 is electrically connected to the electrode 402. In alternative embodiments, the number of in vivo electronic devices may be more than 2, or may be only one; also, one in vivo electronic device may connect two or more electrodes. In this embodiment, the first in-vivo electronic device 301 acquires data of a physiological electrical signal of one site through the electrode 401, and the second in-vivo electronic device 302 acquires data of a physiological electrical signal of another site through the electrode 402. Alternatively, the first in-body electronics 301 applies a stimulus (e.g., a pulse) to the one site via electrodes 401 and the second in-body electronics 302 applies a stimulus (e.g., a pulse) to the other site via electrodes 402.
In the present embodiment, as shown in fig. 2, the external electronic device 200 is disposed outside the patient, connected to the first and second internal electronic devices 301 and 302 by wireless communication, and connected to the main control device 100 by wired communication. Optionally, the in-vitro electronic device 200 and the main control device 100 may also be connected by wireless communication. The in-vitro electronic device 200 sends the collected data uploaded by the first in-vivo electronic device 301 and the second in-vivo electronic device 302 to the main control device 100. In addition, the external electronic device 200 may transmit the stimulation command sent by the main control device 100 to the first intra-body electronic device 301 and the second intra-body electronic device 302, so that the first intra-body electronic device 301 and the second intra-body electronic device 302 generate the stimulation signal according to the stimulation command. In one embodiment of the present invention, the in-vitro electronic device 200 can directly send out the stimulation to the patient in vitro according to the control of the main control device 100, for example, playing sound, image, etc. In some embodiments of the present invention, the master control device 100 may generate a stimulation command according to the acquired data. In other embodiments of the present invention, the master control device 100 may also select a predefined stimulation command, for example, control an in-vivo electronic device or an in-vitro electronic device to send stimulation according to a predefined stimulation mode.
In this embodiment, the main control device 100 is used for controlling and processing the data of the in-vivo electronic devices 301 and 302 and the in-vitro electronic device 200, and comprises: time synchronization of the individual electronic devices 301, 302 in the in-vivo electronic device and 200 in the in-vitro electronic device is achieved according to their timestamp offsets. For example, the first in-vivo electronic device 301 and the second in-vivo electronic device 302 are synchronized in time to collect data, and the external electronic device 200 is synchronized in time to send a stimulus with the in-vivo electronic device to collect data. In an exemplary embodiment, the master control apparatus 100 may perform the time synchronization operation at regular time, thereby controlling the time synchronization of the system within a predetermined accuracy range. In one embodiment of the present invention, the time synchronization includes: selecting a time axis of any one of the electronic devices as baseline time; and adding the difference between the timestamp offset of each of the other electronic devices in each electronic device and the timestamp offset of the electronic device corresponding to the baseline time by taking the baseline time as a reference to obtain the actual time for acquiring data or sending stimulation by the other electronic devices.
The time synchronization method according to the embodiment of the present invention will be specifically described with reference to fig. 2.
When not in synchronization
In contrast, when the time synchronization of the present invention is not performed, the first in-body electronic device 301, the second in-body implanted electronic device 302, and the in-vitro electronic device 200 communicate with the main control device 100 independently, the communication data includes the time stamps of the electronic devices themselves, and the time stamps are self-incremented following the operation of the electronic devices.
The master control device 100 processes data according to the time stamp of each electronic device. Since the respective crystal oscillation performances vary and the time stamp increments differ among the respective electronic apparatuses, processing data according to the time stamp has a synchronization error, and the error becomes larger as time increases.
When synchronizing
The main control device 100 sends the external electronic device 200, the first in-body electronic device 301, and the second in-body electronic device 302 to the external electronic device by setting the synchronization frequency according to the error estimated by the system and the application requirement, that is, initiates synchronization at a predetermined time interval. For example: when the method is used for ERP analysis or analysis of the generation sequence and phase difference of lead signals, the error precision is required to be 1ms, and a short synchronization period can be set; for signal spectrum analysis, etc., the error precision can be controlled at 50ms, and a longer synchronization period can be set to reduce power consumption. In one embodiment of the present invention, the clock error of the electronic system is generally derived from the crystal oscillator, and when the crystal oscillator with 5ppm precision is selected, the clock error of the electronic device is within 5us per second, so that the synchronization period (predetermined time interval) is set within 200s to meet the 1ms time precision requirement. When a crystal oscillator with the precision of 20ppm is selected, the error of the electronic device per second is within 20us, so that the synchronization precision is set within 50s and the requirement of 1ms time precision can be met. Typically, the predetermined time interval may range from 10 seconds to 200 seconds.
The starting synchronization process after the synchronization period is set is as follows:
s010, the main control device 100 sends out synchronous signals to the external electronic device 200, the first in-body electronic device 301 and the second in-body electronic device 302 at regular time.
And S020, after receiving the synchronizing signal of the main control device 100, clearing the timestamp offset of each electronic device, wherein the cleared timestamp offset begins to synchronously and automatically increase along with the running time of the electronic devices.
S030, the master control device 100 receives the respective timestamp offsets uploaded by the electronic devices, takes the time axis of one electronic device in the system as baseline time, and realigns the time for collecting data or the time for sending stimulation according to the timestamp offsets in the data of the electronic devices.
In one embodiment of the present invention, the actual time of each electronic device relative to the baseline time may be determined according to the following formula:
the actual time of the electronic device is the baseline time + (timestamp offset of the electronic device-timestamp offset of the electronic device corresponding to the baseline time)
For example, the timestamp offset of the first in-body electronic device 301 is Δ t1, the timestamp offset of the second in-body electronic device 302 is Δ t2, the timestamp offset of the external electronic device 200 is Δ t3, and the time axis t of the first in-body electronic device 301 is taken as a time base, so that the actual time of the second in-body electronic device 302 is t + (Δ t2- Δ t1) and the actual time of the external electronic device 200 is t + (Δ t3- Δ t 1).
The respective collected data and/or stimuli are then aligned based on the actual time of the respective electronic device.
In the working process of the whole system, the synchronization processes S010-S030 are repeated according to the set synchronization period or the preset time interval, so that the time error of the data of each electronic device in the system is ensured to be within 1 millisecond in the recording process of 24 hours.
In the present exemplary embodiment, the synchronization method of the present invention is explained taking two in-vivo electronic devices as an example. In alternative embodiments, the electronic therapy system may include more than three in vivo electronic devices, each of which may be connected to more than two electrodes. In other embodiments, the electronic therapy system may also include an in vivo electronic device that may be coupled to 1 or more than 2 electrodes.
Fig. 3 shows an electronic therapy system according to another embodiment of the invention. In this embodiment, the electronic treatment system further includes 1 in-vivo electronic device 300 disposed inside the body, in addition to the main control device 100 and the in-vitro electronic device 200 disposed outside the body according to the above embodiments. The in-vivo electronic device 300 is connected by connecting leads to two electrodes 401, 402 arranged at two different locations. Of course, in alternative embodiments, the in vivo electronic device 300 may be connected to one electrode, or may be connected to more than three electrodes. In the present embodiment, the in-vivo electronic device 300 is wirelessly connected to the in-vitro electronic device 200, and the in-vitro electronic device 200 is wired to the main control device 100.
In this embodiment, when the synchronization function is activated, the main control device 100 sends out a synchronization signal to the external electronic device 200 and the in-vivo electronic device 300 at regular time. After the in-vitro electronic device 200 and the in-vivo electronic device 300 receive the synchronization signal of the main control device 100, the timestamp offsets of the in-vitro electronic device and the in-vivo electronic device are cleared, and the cleared timestamp offsets begin to increase automatically and synchronously along with the running time of the corresponding electronic devices. The master control device 100 receives the respective timestamp offsets sent by the electronic devices, may use the time axis of the in-vitro electronic device 200 as a baseline time, and may calculate the time offset of the in-vivo electronic device 300 relative to the in-vitro electronic device 200 according to the received timestamp offsets of the in-vivo electronic device 300 and the timestamp offsets of the in-vitro electronic device 200, and obtain the actual time of the in-vivo electronic device 300 relative to the baseline time by adding the calculated time offsets to the baseline time, thereby synchronizing the time of acquiring data by the in-vivo electronic device 300 with the time of sending a stimulus by the in-vitro electronic device 200. In this embodiment, the stimulation emitted by the in-vitro electronic device 200 to the human body may include visual stimulation (e.g., images), auditory stimulation (e.g., sounds), or other stimulation (e.g., bone conduction).
According to the embodiment, the time stamp offset of each electronic device in the system is extracted, the time of executing operation (including data acquisition and stimulation sending) of each electronic device is aligned through the time stamp offset, and compared with the existing method that the time is aligned only according to the time stamp, the time deviation caused by self-increment of the time stamp is avoided, the synchronization precision is improved, and particularly the time synchronization requirement of the electronic medical system on data processing can be met.
The electronic treatment system provided by the present invention is explained in detail above, and the synchronization method provided by the present invention is specifically described below.
Fig. 4 is a flowchart of a method for time synchronization for an electronic therapy system according to an exemplary embodiment of the present invention. As described above, the electronic therapy system may include an extracorporeal electronic device and at least one in-vivo electronic device, each of the at least one in-vivo electronic device being electrically connected to at least one electrode disposed within a patient, the method may include:
s100, acquiring timestamp offsets of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device;
s200: and realizing the time synchronization of the electronic devices according to the respective timestamp offsets of the electronic devices. Optionally, in the step S200, a time axis of any one of the electronic devices is selected as a baseline time; and adding the difference between the timestamp offset of each of the other electronic devices in each electronic device and the timestamp offset of the electronic device corresponding to the baseline time by taking the baseline time as a reference to obtain the actual time for acquiring data or sending stimulation by the other electronic devices.
Fig. 5 is a flowchart of a method for time synchronization for an electronic therapy system according to another exemplary embodiment of the present invention. In this embodiment, the method may include:
s501, sending a synchronization signal to each electronic device to clear the timestamp offset of each electronic device, wherein the cleared timestamp offset begins to synchronously and automatically increase along with the running time;
s502, acquiring timestamp offsets of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device;
s503, selecting a time axis of any one of the electronic devices as a time base line;
and S504, aligning the time for acquiring the data or the time for sending the stimulation according to the respective timestamp offset of each in-vivo electronic device.
In one embodiment of the present invention, in the process S504, a time offset of each electronic device relative to the time of the baseline is determined according to the received timestamp offset, and the time offset is aligned with the time baseline based on the time offset of each electronic device, so as to realize time synchronization of each electronic device for acquiring data or sending stimulation.
In another embodiment of the present invention, in the processing S504, the actual time of each electronic device relative to the baseline time may be determined according to the following formula:
the actual time of the electronic device is the baseline time + (timestamp offset of the electronic device-timestamp offset of the electronic device corresponding to the baseline time)
For example, the timestamp offset of the first in-body electronic device is Δ t1, the timestamp offset of the second in-body electronic device is Δ t2, the timestamp offset of the external electronic device is Δ t3, and the time axis t of the first in-body electronic device is taken as a time base, so that the actual time of the second in-body electronic device is t + (Δ t2- Δ t1) and the actual time of the external electronic device is t + (Δ t3- Δ t 1).
The respective collected data and/or stimuli are then aligned based on the actual time of the respective electronic device.
In an alternative embodiment of the invention, the method may be performed at predetermined time intervals, and the accuracy of the time synchronization may be controlled within a predetermined range, for example, the predetermined time intervals may comprise 10 seconds to 200 seconds. Specifically, the clock error of the electronic system generally comes from the crystal oscillator, and when the crystal oscillator with 5ppm precision is selected, the error of the electronic device is within 5us per second, so that the synchronization period (predetermined time interval) is set within 200s, and the requirement of 1ms time precision can be met. When a crystal oscillator with the precision of 20ppm is selected, the error of the electronic device per second is within 20us, so that the synchronization precision is set within 50s and the requirement of 1ms time precision can be met.
From the above, the synchronization method of the present invention can control the time accuracy requirement to be 1ms, which is enough to satisfy the requirement of the electronic treatment field for data processing.
Through the above description of the embodiments, those skilled in the art will clearly understand that the present invention can be implemented by combining software and a hardware platform. With this understanding in mind, all or part of the technical solutions of the present invention that contribute to the background can be embodied in the form of a software product, which can be stored in a storage medium, such as a ROM/RAM, a magnetic disk, an optical disk, etc., and includes instructions for causing a computer device (which can be a personal computer, a server, or a network device, etc.) to execute the methods according to the embodiments or some parts of the embodiments of the present invention.
Accordingly, a computer-readable storage medium according to an embodiment of the present invention stores thereon computer instructions, which when executed by a processor, implement the method, process, operation, and the like described in any of the above embodiments.
Furthermore, fig. 6 shows a control device for use in an electronic therapy system according to an exemplary embodiment of the present invention. As shown in fig. 6, the control device includes:
a communication interface 601 communicating with at least one in-vivo electronic device implanted in the patient's body through an in-vitro electronic device connected thereto;
a memory 602 having stored thereon computer instructions;
a processor 603 for executing the computer instructions to perform the following operations: time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device is achieved according to a timestamp offset of the respective electronic device.
In one embodiment of the present invention, the processor 603 executing the computer instructions to achieve time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device according to a timestamp offset of the each electronic device comprises: selecting a time axis of any one of the electronic devices as baseline time; and adding the difference between the timestamp offset of each of the other electronic devices in each electronic device and the timestamp offset of the electronic device corresponding to the baseline time by taking the baseline time as a reference to obtain the actual time for acquiring data or sending stimulation by the other electronic devices.
In another embodiment of the present invention, the processor 603 executing the computer instructions to achieve time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device according to a timestamp offset of the each electronic device comprises: sending out a synchronization signal to each electronic device; each electronic device clears the self timestamp offset after receiving the synchronization signal, and the cleared timestamp offset begins to synchronously and automatically increase along with the running time; the main control device receives the timestamp offset of each electronic device; and the master control device takes the time axis of any one of the electronic devices as a time base line, and aligns the time for acquiring data or the time for sending stimulation according to the respective timestamp offset of each in-vivo electronic device.
In other embodiments of the present invention, the processor 603 executes the computer instructions to perform operations for achieving time synchronization of the respective electronic devices according to timestamp offsets of the respective electronic devices of the at least one in-vivo electronic device and the in-vitro electronic device at predetermined time intervals. Wherein the predetermined time interval may include 10 seconds to 200 seconds.
In an alternative embodiment of the present invention, the processor 603 executes the computer instructions to store the synchronized collected data in the memory 602, but the data may be stored in other storage devices. In a further embodiment of the present invention, the master control device further comprises a display (not shown), wherein the processor 603 executes the computer instructions to display the synchronized collected data through the display.
In a further embodiment of the present invention, the processor 603 executes the computer instructions to further perform the following operations: generating a stimulation command or selecting a predefined stimulation command according to the acquired data; sending the stimulation command to one or more of the at least one in vivo implanted electronic device and an in vitro electronic device.
Figure 7 shows an in-vivo electronic device adapted to be implanted in a patient according to an exemplary embodiment of the present invention. In addition to having features common to devices implantable in a patient of the art, the in vivo electronic device, as shown in figure 7, further comprises:
a communication interface 701 that communicates with the control apparatus via an in vitro electronic apparatus wirelessly connected thereto;
a memory 702 having computer instructions stored thereon;
a processor 703 for executing the computer instructions to send the acquired data acquired via the electrodes of the physiological condition in the patient and the timestamp offset to the control device via the communication interface 701, so that the control device can time-synchronize with other electronic devices according to the timestamp offset as described above.
In this embodiment, the processor 703 executes the computer instructions to perform the following operations: according to the received synchronization signal from the control device, the self timestamp offset is cleared, and the cleared timestamp offset begins to synchronously and automatically increase along with the running time; and sending the acquired data acquired by the electrode and the timestamp offset to the control device through the communication interface.
In an alternative embodiment of the invention, the processor 703 executes the computer instructions to perform the following operations: generates a stimulation signal (e.g., a pulse) according to a stimulation command received by the communication interface 701 from the control device, and transmits the stimulation signal to the corresponding electrode.
Fig. 8 shows an extracorporeal electronic device according to an exemplary embodiment of the present invention. As shown in fig. 8, the in vitro electronic device may include:
a communication interface 801 that connects with an in-vivo electronic device through a wireless connection and communicates with a control device through a wireless connection or a wired connection;
a memory 802 having computer instructions stored thereon;
a processor 803 for executing the computer instructions to send a timestamp offset to the control device, enabling the control device to time synchronize according to the timestamp offset and a timestamp offset of the in-vivo electronic device as described above.
In this embodiment, the processor 803 executes the computer instructions to perform the following operations: according to the received synchronization signal from the control device, the self timestamp offset is cleared, and the cleared timestamp offset begins to synchronously and automatically increase along with the running time; the timestamp offset of itself and the timestamp offset from the in-vivo electronic device are sent to the control device via the communication interface 801.
In an alternative embodiment of the invention, the in vitro electronic device further comprises a stimulation generator (not shown), and the processor 803 executes the computer instructions to: the stimulation generator is controlled to send external stimuli to the patient according to the stimulation commands received by the communication interface 801 from the control device, for example, the external stimuli may include auditory stimuli, visual stimuli, and tactile stimuli.
In summary, according to various embodiments of the present invention, a plurality of in-vivo electronic devices can cooperate with each other. Due to the fact that the plurality of in-vivo electronic devices are adopted, extra operative trauma caused by connecting lines is reduced, signal interference is reduced, and application of synchronous signal acquisition, stimulation, drug administration and the like at a longer distance is achieved. The in-vivo electronic devices or the in-vivo electronic devices and the in-vitro electronic devices can be accurately synchronized, and the time errors of the electronic devices can be controlled within +/-1 millisecond within 24 hours.
Various aspects of the invention are described in detail above with respect to various embodiments. It should be understood by those skilled in the art that the foregoing is only illustrative of the present invention, and is not intended to limit the scope of the invention. For example, the processing and functions implemented by each of the extracorporeal electronic device and the master control device may be integrated on a single computer device, but such changes would still fall within the scope of the present invention as set forth in the claims.

Claims (34)

1. An electronic therapy system, comprising:
at least one in-vivo electronic device adapted to be disposed within the body of a patient, each of the at least one in-vivo electronic device being electrically connected to at least one electrode disposed within the body of the patient;
an extracorporeal electronic device adapted to be disposed outside the patient's body, wirelessly connected with the at least one in-vivo electronic device; and
the main control device is suitable for being arranged outside the body of a patient and is in wired or wireless connection with the in-vitro electronic device, and is used for controlling and processing data of the in-vivo electronic device and the in-vitro electronic device;
wherein, the main control device controls and processes the data of the in vivo implanted electronic device and the in vitro electronic device, and comprises: time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device is achieved according to a timestamp offset of the respective electronic device.
2. The electronic therapy system according to claim 1, wherein the timing achieves time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device based on a timestamp offset of the respective electronic device.
3. The electronic therapy system according to claim 1, wherein said master control device achieving time synchronization of each of said at least one in-vivo electronic device and in-vitro electronic device according to a timestamp offset of said each electronic device comprises:
selecting a time axis of any one of the electronic devices as baseline time;
and adding the difference between the timestamp offset of other electronic devices in each electronic device and the timestamp offset of the electronic device corresponding to the baseline time by taking the baseline time as a reference to obtain the actual time for acquiring data or sending stimulation by the other electronic devices.
4. The electronic therapy system according to claim 1, wherein said master control device achieving time synchronization of each of said at least one in-vivo electronic device and in-vitro electronic device according to a timestamp offset of said each electronic device comprises:
the master control device sends out a synchronous signal to each electronic device;
each electronic device clears the self timestamp offset after receiving the synchronization signal, and the cleared timestamp offset begins to synchronously and automatically increase along with the running time;
the main control device receives the timestamp offset of each electronic device;
and the master control device takes the time axis of any one of the electronic devices as a time base line, and aligns the time for acquiring data or the time for sending stimulation according to the respective timestamp offset of each in-vivo electronic device.
5. The electronic therapy system according to claim 4, wherein said master control unit sends out synchronization signals to said respective electronic devices at predetermined time intervals.
6. The electronic therapy system according to claim 5, wherein the predetermined time interval is 10 to 200 seconds.
7. The electronic therapy system according to any one of claims 1 to 5, wherein the master control device controls and processes data of the in-vivo implanted electronic device and the in-vitro electronic device further comprises:
and storing and/or displaying the acquired data after time synchronization.
8. The electronic therapy system according to claim 7, wherein the master control device controls and processes data of the in vivo implanted electronic device and the in vitro electronic device further comprises:
generating a stimulation command or selecting a predefined stimulation command according to the acquired data;
transmitting the stimulation command to one or more of the at least one in-vivo electronic device and an in-vitro electronic device.
9. The electronic therapy system according to claim 8, wherein the in vivo implanted electronics receiving the stimulation command generate stimulation signals according to the stimulation command and transmit the stimulation signals to the respective electrodes.
10. The electronic therapy system according to claim 8, wherein the extracorporeal electronics receiving the stimulation command sends extracorporeal stimulation to the patient at a synchronized time.
11. The electronic therapy system according to claim 10, wherein the in vitro stimulation comprises auditory stimulation, visual stimulation, tactile stimulation.
12. The electronic therapy system according to claim 1, wherein data of physiological electrical signals of a patient are acquired through the electrodes or stimulation signals are sent to the patient.
13. The electronic therapy system according to claim 1, wherein the master control device and the extracorporeal electronic device are integrated on a single device.
14. A control device for use in an electronic therapy system, the control device comprising:
a communication interface for communicating with at least one in-vivo electronic device implanted in a patient via an in-vitro electronic device connected thereto;
a memory having computer instructions stored thereon;
a processor for executing the computer instructions to perform the following operations: time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device is achieved according to a timestamp offset of the respective electronic device.
15. The control device of claim 14, wherein the processor executing the computer instructions to achieve time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device according to a timestamp offset of the respective electronic device comprises:
selecting a time axis of any one of the electronic devices as baseline time; and adding the difference between the timestamp offset of each of the other electronic devices in each electronic device and the timestamp offset of the electronic device corresponding to the baseline time by taking the baseline time as a reference to obtain the actual time for acquiring data or sending stimulation by the other electronic devices.
16. The control device of claim 14, wherein the processor executing the computer instructions to achieve time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device according to a timestamp offset of the respective electronic device comprises:
sending a synchronization signal to each electronic device, wherein each electronic device clears the timestamp offset of the electronic device after receiving the synchronization signal, and the cleared timestamp offset begins to synchronously and automatically increase along with the running time;
the main control device receives the timestamp offset of each electronic device;
and the master control device takes the time axis of any one of the electronic devices as a time base line, and aligns the time for acquiring data or the time for sending stimulation according to the respective timestamp offset of each in-vivo electronic device.
17. The control device of any one of claims 14 to 16, wherein the processor executes the computer instructions to perform operations to achieve time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device according to a timestamp offset of the respective electronic device at predetermined time intervals.
18. The control device of claim 17, wherein the predetermined time interval comprises 10 seconds to 200 seconds.
19. The control device of claim 14, wherein the processor executes the computer instructions to store the synchronized collected data in the memory or other storage device.
20. The control device of claim 14, further comprising a display, wherein the processor executes the computer instructions to present the synchronized collected data via the display.
21. The control device of claim 14, wherein the processor executes the computer instructions to further perform the following:
generating a stimulation command or selecting a predefined stimulation command according to the acquired data;
sending the stimulation command to one or more of the at least one in vivo implanted electronic device and an in vitro electronic device.
22. An in-vivo electronic device adapted to be implanted in a patient, the in-vivo electronic device comprising:
a communication interface for communicating with a control device via an in vitro electronic device wirelessly connected thereto or directly with the control device via a wireless connection;
a memory having computer instructions stored thereon;
a processor for executing the computer instructions to send the acquired data acquired via the electrodes of the physiological condition in the patient and the timestamp offset to the control device via the communication interface, such that the control device can perform time synchronization with other electronic devices according to the timestamp offset.
23. The in-vivo electronic device according to claim 22, wherein said processor executes said computer instructions to:
according to the received synchronization signal from the control device, the self timestamp offset is cleared, and the cleared timestamp offset begins to synchronously and automatically increase along with the running time;
and sending the acquired data acquired by the electrode and the timestamp offset to the control device through the communication interface.
24. The in-vivo electronic device according to claim 22, wherein said processor executes said computer instructions to:
and generating a stimulation signal according to the stimulation command received by the communication interface from the control device, and sending the stimulation signal to the corresponding electrode.
25. An in vitro electronic device, comprising:
a communication interface that communicates with the in-vivo electronic device through a wireless connection and communicates with the control device through a wireless connection or a wired connection;
a memory having computer instructions stored thereon;
a processor for executing the computer instructions to send a timestamp offset to the control device, such that the control device can achieve time synchronization according to the timestamp offset and a timestamp offset of the in-vivo electronic device.
26. The in-vitro electronic device according to claim 25, wherein the processor executes the computer instructions to:
according to the received synchronization signal from the control device, the self timestamp offset is cleared, and the cleared timestamp offset begins to synchronously and automatically increase along with the running time;
and sending the timestamp offset of the in-vivo electronic device and the timestamp offset from the in-vivo electronic device to the control device through the communication interface.
27. The in vitro electronic device of claim 25, further comprising a stimulus generator,
the processor executes the computer instructions to:
and controlling the stimulation generator to send the external stimulation to the patient according to the stimulation command received by the communication interface from the control device.
28. The in-vitro electronic device according to claim 27, wherein the in-vitro stimulus comprises an auditory stimulus, a visual stimulus, a tactile stimulus.
29. A method for time synchronization of an electronic therapy system, the electronic therapy system comprising an extracorporeal electronic device and at least one in-vivo electronic device, each of the at least one in-vivo electronic device being electrically connected to at least one electrode disposed within a patient, the method comprising:
obtaining a timestamp offset for each of the at least one in-vivo electronic device and the in-vitro electronic device;
and realizing the time synchronization of the electronic devices according to the respective timestamp offsets of the electronic devices.
30. The method of claim 29, wherein the time synchronizing of each of the at least one in-vivo electronic device and the in-vitro electronic device according to the timestamp offset of the respective electronic device comprises:
selecting a time axis of any one of the electronic devices as baseline time;
and adding the difference between the timestamp offset of each of the other electronic devices in each electronic device and the timestamp offset of the electronic device corresponding to the baseline time by taking the baseline time as a reference to obtain the actual time for acquiring data or sending stimulation by the other electronic devices.
31. The method of claim 29, further comprising:
before the timestamp offsets of the electronic devices are obtained, sending a synchronization signal to the electronic devices to clear the timestamp offsets of the electronic devices, wherein the cleared timestamp offsets begin to synchronously and automatically increase along with the running time;
wherein achieving time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device according to a timestamp offset of the respective electronic device comprises: and aligning the time for acquiring data or the time for sending the stimulation according to the respective timestamp offsets of the in-vivo electronic devices by taking the time axis of any one of the electronic devices as a time base line.
32. A method according to any one of claims 29 to 31, characterized in that the steps of the method are performed at predetermined time intervals.
33. The method of claim 32, wherein the predetermined time interval comprises 10 seconds to 200 seconds.
34. A computer readable storage medium having computer instructions stored thereon which, when executed by a processor, implement the method of any one of claims 29 to 33.
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