CN111040021A - 一种改善生物活性蛋白性质的载体蛋白 - Google Patents

一种改善生物活性蛋白性质的载体蛋白 Download PDF

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CN111040021A
CN111040021A CN201811190459.7A CN201811190459A CN111040021A CN 111040021 A CN111040021 A CN 111040021A CN 201811190459 A CN201811190459 A CN 201811190459A CN 111040021 A CN111040021 A CN 111040021A
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黄岩山
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Zhejiang Doer Biologics Co Ltd
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Abstract

本文提供一种用于改善生物活性蛋白的性质的载体蛋白，该载体蛋白的结构为G‑X‑Y三元重复结构，其中G为甘氨酸，X和Y各自独立选自脯氨酸、丙氨酸和谷氨酸。本文还提供含有该载体蛋白和生物活性蛋白的融合蛋白。本文的融合蛋白具有改善的生物学性质，例如改善的药代动力学和理化性质。

Description

一种改善生物活性蛋白性质的载体蛋白
技术领域
本发明涉及生物技术领域，具体涉及一种可以改善活性蛋白性质的载体蛋白。
背景技术
众所周知，分子量小于70kDa的蛋白质或多肽容易通过肾过滤而被体内清除(Jevsevar S,Kunstelj M,Porekar VG，PEGylation of therapeutic proteins，Biotechnol J.，5:113–28，2010)。因此，一般采用融合或交联分子量较大的载体蛋白、聚乙二醇(PEG)、脂肪酸等来增加其表观分子量和流体动力学半径，从而降低其肾小球滤过率(Kontermann RE，Strategies to extend plasma half-lives of recombinantantibodies，BioDrugs，23:93–109；2009；Kang JS等，Emerging PEGylated drugs.ExpertOpin Emerg Drugs.，14:363–80，2009)，并最终达到延长蛋白或多肽体内半衰期的目的。
用作交联使用的载体一般是PEG或脂肪酸等，而人血清白蛋白、免疫球蛋白Fc片段、转铁蛋白等则普遍用于重组融合，并且大都有对应的成功上市药物。近年来，新型的重组融合载体蛋白不断涌现(WR Strohl，Fusion Proteins for Half-Life Extension ofBiologics as a Strategy to Make Biobetters，Biodrugs，2015,29(4):215-39)，如URP(中国专利ZL200780015899.2)、XTEN(中国专利申请CN201080011467.6；VolkerSchellenberger等，A recombinant polypeptide extends the in vivo half-life ofpeptides and proteins in a tunable manner.Nature Biotechnology 27(12):1186，2009)、类弹性蛋白ELP(MacEwan SR,Chilkoti A.,Applications of elastin-likepolypeptides in drug delivery.J Control Release.2014；190:314-30.)、PAS(专利号ZL200880019017，M Schlapschy等，PASylation:a biological alternative toPEGylation for extending the plasma half-life of pharmaceutically activeproteins.Protein Engineering Design&Selection Peds.2013,26(8):489-501)和GLK(中国专利号200980103870.9)等。其中XTEN和ELP融合制备的蛋白药物已经用于临床试验中(Yuen KC等，A long-acting human growth hormone with delayed clearance(VRS-317):results of a double-blind,placebo-controlled,single ascending dose studyin growth hormone-deficient adults,J Clin Endocrinol Metab.,98(6):2595-603.2013；Christiansen M等，Weekly Subcutaneous Doses of Glymera(PB1023)a NovelGLP-1 Analogue Reduce Glucose Exposure Dose Dependently，http://phasebio.com/)。这些人工设计的非天然蛋白质，在跟某些活性蛋白或多肽通过重组表达或者交联后形成的融合蛋白或产物，相比于单独的活性蛋白和多肽，显著地提高了血清稳定性并延长了其体内半衰期，最终改善了治疗效果。
专利号为ZL200780015899.2的中国专利公开了一种非结构化重组聚合物(URP)，其基本不能非特异性结合血清蛋白，其特征在于：(a)含有至少100个毗连氨基酸；(b)所述URP中所含的甘氨酸(G)、天冬氨酸(D)、丙氨酸(A)、丝氨酸(S)、苏氨酸(T)、谷氨酸(E)和脯氨酸(P)残基之和占所述URP中全部氨基酸的约80％以上；(c)经Chou-Fasman算法测定，所述URP序列的至少50％氨基酸不形成二级结构；(d)所述URP的T表位评分小于-4。
申请号为CN201080011467.6的中国专利申请公开了一种分离的延伸重组多肽(XTEN)，包含超过大约400至大约3000个氨基酸残基，其中该XTEN的特征在于：(a)甘氨酸(G)、丙氨酸(A)、丝氨酸(S)、苏氨酸(T)、谷氨酸(E)和脯氨酸(P)残基的总和占XTEN的总氨基酸序列的超过大约80％；(b)该XTEN序列基本是非重复的；(c)当通过TEPITOPE算法分析时，该XTEN序列缺乏预测的T细胞表位，其中对XTEN序列内表位的TEPITOPE算法预测是基于-9或更高的得分；(d)通过GOR算法确定，该XTEN序列具有超过90％的无规卷曲形成；和(e)通过Chou-Fasman算法确定，该XTEN序列具有少于2％的α螺旋和少于2％的β-折叠。
专利号为ZL200880019017的中国专利公开了包含至少两个结构域的生物学活性蛋白，其中：(a)所述至少两个结构域的第一结构域包含具有和/或介导所述生物学活性的氨基酸序列；以及(b)所述至少两个结构域的第二结构域包含形成无规卷曲构象的由至少10个氨基酸残基组成的氨基酸序列，其中所述第二结构域由丙氨酸、丝氨酸和脯氨酸残基组成，其中所述无规卷曲构象介导所述生物学活性蛋白体内和/或体外稳定性的增加。
类弹性蛋白ELP是由(VPGXG)n组成，其中X可以是除脯氨酸(Pro)之外的任意氨基酸。n的数目不固定，ELP有在特定温度(跨度为2-3℃)下状态会发生急剧转变的特性：低于这一温度，ELP呈可溶状态；高于这一温度，ELP会发生快速聚集成微米级肉眼可见的颗粒物；再次降低温度，ELP又会重新溶解；这一温度称之为反向转换温度，简称相变温度(Tt)。ELP属于弹性蛋白，具有生物降解性和非免疫原性，因此适用于作为延长药物半衰期的融合蛋白使用。
专利号为ZL200980103870.9的中国专利公开了一种用于延长蛋白体内半衰期的重组明胶样单元(GLK)，其特征在于，所述的明胶样单元是结构如下的多肽：(Gly-X-Y)n，式中，Gly为甘氨酸残基；X和Y分别为20种天然氨基酸除了Cys之外的任意氨基酸残基，以及Hyp；n为20-300；并且，所述的明胶样单元具有以下特征：(a)所述明胶样单元中以下亲水性氨基酸Asn，Asp，Gln，Glu，Lys，Pro，Ser，Hyp，Arg的氨基酸百分比含量总和为40％至2/3；(b)所述明胶样单元中，Pro和Hyp的数量之和与n的比值≥0.6；(c)Gly的数量之和与n的比值≤1.15；且，根据ProtParam公式计算，代表亲水性的GRAVY值小于-1.1；附加条件是，所述的明胶样单元不是天然的明胶蛋白。
上述几种新型载体蛋白与传统的白蛋白和免疫球蛋白IgG Fc片段的不同之处在于，其大部分序列中氨基酸种类较少，一般只由少数几种特定氨基酸组成。在类弹性蛋白ELP的VPGXG组成单元里，对于X位的氨基酸电荷及亲水性并无严格限定。而URP和XTEN的设计强调采用亲水性氨基酸，并加入了带负电荷的天冬氨酸和/或谷氨酸进一步延长半衰期，这是“由于人或动物的大多数组织和表面具有净负电荷，XTEN序列可以设计为具有净负电荷以使含有XTEN的组合物与各种表面如血管、健康组织或各种受体之间的非特异性相互作用最小化”(CN201080011467.6)；相反，PAS则着重于模仿聚乙二醇(PEG)，采用不带电的三种氨基酸：脯氨酸、丙氨酸和丝氨酸组成。另一方面，XTEN序列强调“基本上非重复”这一特征：“重复氨基酸序列具有聚集形成更高级结构的倾向，其例子为天然重复序列如胶原蛋白和亮氨酸拉链，或者形成接触，导致晶体或拟晶体结构。相反，非重复序列聚集的低倾向使得能够设计具有相对较低频率的带电荷氨基酸的长序列XTEN，如果序列重复它可能聚集”。XTEN技术对于“基本上非重复”的解释为“指在肽或多肽序列中缺乏或有限程度的内部同源性。例如，在该序列的四个连续氨基酸中极少或者没有一个是相同的氨基酸类型，或者该多肽具有10或更低的亚序列得分，或者在从N端到C端的顺序中没有构成该多肽序列的基序的模式”。
尽管活性蛋白或多肽与这些载体蛋白融合或交联后可能会显著减弱其生物学活性，例如Gething NC等报道，胰高血糖素-XTEN融合蛋白仅表现出未修饰的胰高血糖素多肽的15％生物活性(Gething NC等，Gcg-XTEN:an improved glucagon capable ofpreventing hypoglycemia without increasing baseline blood glucose,PLoS One,2010,5(4):e10175)，然而融合或交联后带来的稳定性和溶解性等理化性质的提高却弥补了这方面的缺陷。
发明内容
本文提供一种类明胶单元，其具有以下重复结构：
(G-X-Y)n
其中，G为甘氨酸，X和Y各自独立选自脯氨酸、丙氨酸和谷氨酸；n为5-20的整数，优选n为6-20或9-15的整数。示例性的类明胶单元可选自SEQ ID NO:17-89中任一奇数编号的序列所示的类明胶单元；优选地，所述类明胶单元选自SEQ ID NO:17、SEQ ID NO:19、SEQID NO:21、SEQ ID NO:25、SEQ ID NO:27、SEQ ID NO:29和SEQ ID NO:31。
本文还提供一种类明胶蛋白，该类明胶蛋白含有至少两个本文所述的类明胶单元；所述至少两个类明胶单元可相同或可不同；优选地，所述类明胶蛋白中，丙氨酸的含量大于等于10％，优选大于等于12％，更优选大于等于15％，更优选大于等于18％，更优选大于等于20％；优选丙氨酸含量≤45％，如≤40％或小于等于35％；优选地，所述类明胶单元中，代表亲水性的GRAVY值大于-1.1，优选大于等于-1.0，更优选大于等于-0.9，更优选大于等于-0.8，优选该值≤0，如≤-0.1或≤-0.2。优选地，该类明胶蛋白具有100-2000个氨基酸。示例性的类明胶蛋白可选自SEQ ID NO:91-185中任一奇数编号所示的序列，或可含有两条或两条以上(如2-20条)SEQ ID NO:91-185中任一奇数编号所示的序列。示例性的含有两条或两条以上SEQ ID NO:91-185中任一奇数编号所示的序列的类明胶蛋白优选是两条或两条以上相同的所述序列的串联重复序列，包括但不限于SEQ ID NO:231第1-231位氨基酸残基序列、SEQ ID NO:239第1-573位氨基酸残基序列、SEQ ID NO:263第1-915位氨基酸残基序列、SEQ ID NO:265第1-864位氨基酸残基序列、SEQ ID NO:267第1-864位氨基酸残基序列、SEQ ID NO:269第1-864位氨基酸残基序列、SEQ ID NO:271第1-864位氨基酸残基序列、SEQ ID NO:273第1-864位氨基酸残基序列、SEQ ID NO:275第1-915位氨基酸残基序列、SEQ ID NO:279第1-216位氨基酸残基序列、SEQ ID NO:281第1-216位氨基酸残基序列、SEQ ID NO:283第1-231位氨基酸残基序列、SEQ ID NO:293第1-687位氨基酸残基序列、SEQID NO:295第1-648位氨基酸残基序列、SEQ ID NO:297第1-648位氨基酸残基序列、SEQ IDNO:299第1-687位氨基酸残基序列、SEQ ID NO:303第34-948位氨基酸残基序列、SEQ IDNO:305第34-948位氨基酸残基序列和SEQ ID NO:309第1-1029位氨基酸残基序列。优选地，类明胶蛋白包括与本段所述任一氨基酸序列具有80％以上同一性百分比、优选85％以上同一性百分比、更优选90％以上同一性百分比、更优选95％以上同一性百分比的氨基酸序列。
本文还提供一种融合蛋白，该融合蛋白含有本文公开的类明胶蛋白和生物活性蛋白。示例性的融合蛋白可选自：SEQ ID NO:211-239、247-259和263-309中任一奇数编号的序列所示的融合蛋白。
本文还提供一种多核苷酸序列，选自：
(1)编码本文所述的类明胶单元、类明胶蛋白或融合蛋白的多核苷酸序列；和
(2)(1)所述多核苷酸序列的互补序列。
本文还提供一种核酸构建体，其包含本文所述的多核苷酸序列；优选地，所述核酸构建体为克隆载体或表达载体。
本文还提供一种宿主细胞，所述宿主细胞：
(1)含有本文所述的多核苷酸序列和/或核酸构建体；和/或
(2)表达本文所述的类明胶单元、类明胶蛋白和/或融合蛋白。
本文还提供选自以下的应用：
(1)本文所述的类明胶单元或其编码序列或该编码序列的互补序列在制备类明胶蛋白或含该类明胶蛋白的融合蛋白中的应用；
(2)本文所述的类明胶蛋白或其编码序列或该编码序列的互补序列在制备含有该类明胶蛋白的融合蛋白中的应用，或在提高生物活性蛋白的药代动力学和/或增强生物活性蛋白的理化性质中的应用；
(3)本文所述的融合蛋白、其编码序列或含该编码序列或其互补序列的核酸构建体在制备药物中的应用。
还提供一种制备能改善生物活性蛋白的生物学性质或生物学功能的载体蛋白的方法，该方法采用化学合成方法或重组技术制备所述载体蛋白；其中，所述载体蛋白的结构为G-X-Y三元重复结构，其中G为甘氨酸，X和Y各自独立选自脯氨酸、丙氨酸和谷氨酸；
其中，所述重组技术包括构建表达该载体蛋白的表达载体，使用该表达载体转化宿主细胞，以及培养宿主细胞以使其表达产生所述载体蛋白；
其中，所述化学合成方法包括，按照所述载体蛋白的结构将选自甘氨酸、脯氨酸、丙氨酸和谷氨酸中的氨基酸残基依次连接到肽链上，形成具有G-X-Y三元重复结构的所述载体蛋白。
还提供的是甘氨酸、脯氨酸、丙氨酸和谷氨酸在制备能改善生物活性蛋白的生物学性质或功能的载体蛋白中的应用。
下文将对本文公开的各方面进行详细的描述。
附图说明
图1：GS100R9-hArg1融合蛋白在Sepax SRT
Figure BDA0001827374440000051
上的表观分子量。1、GS100R9-hArg1；M1、甲状腺球蛋白(Thyroglobulin,669kDa)；M2、铁蛋白(Ferritin,440KD)；M3、醛缩酶(Aldolase，158KD)；M4、伴清蛋白(Conalbumin，75KD)；M5、卵清蛋白(Ovalbumin,44KD)。
图2：GS-hArg1融合蛋白在Sepax SRT-1000SEC上的表观分子量。1、GS200R9-hArg1-GS200R9；2、GS100R9-hArg1-GS100R9；3、GS100R35-hArg1-GS100R35；M1、甲状腺球蛋白(Thyroglobulin,669kDa)；M2、铁蛋白(Ferritin,440KD)+醛缩酶(Aldolase,158KD)+伴清蛋白(Conalbumin,75KD)+卵清蛋白(Ovalbumin,44KD)。
图3：GS-hArg1融合蛋白药代结果图。
图4：蛋白样品糖基化检测结果图。A显示糖染前的结果，B显示糖染后的结果。泳道1、2为阳性对照蛋白；泳道3：GS100R9-hArg1-GS100R9；泳道4：GS100R35-hArg1-GS100R35；泳道5：GS100R52-hArg1-GS100R52；泳道6：GS100R74-hArg1-GS100R74；泳道7：GS100R77-hArg1-GS100R77；泳道8：GS100R98-hArg1-GS100R98；泳道9：GS100R112-hArg1-GS100R112；泳道10-11分别为两个独立批次的rGLK1164-hArg1。
图5：经过不同温度处理之后的GS与GH融合蛋白的SDS-PAGE电泳图。泳道1和8：GS800R9-GH-GS100R9；泳道2和9：GS800R35-GH-GS100R35；泳道3和10：GS800R127-GH-GS100R127；泳道4和11：GS800L91-GH-GS100L91；泳道5和12：GS800L102-GH-GS100L102；泳道6和13：GS800L146-GH-GS100L146；泳道7和14：GS800S203-GH-GS100S203。其中泳道1-7为室温放置30分钟样品，泳道8-14为85℃下处理30分钟的样品。M为蛋白分子量MARKER：200、116、97.2、66.4、44.3KD。
图6：GS与hGH融合蛋白样品的聚体分析情况图。
图7：GS与hGH融合蛋白的体外细胞活性结果图。
图8：GS与GDF15融合蛋白的SDS-PAGE电泳图。泳道1-4分别为：GS600R9-GDF15、GS600L23-GDF15、GS600L136-GDF15、GS600S14-GDF15；泳道5-8分别为：GS400R9-GDF15、GS400L23-GDF15、GS400L136-GDF15、GS400S14-GDF15；泳道9-12分别为：GS200R9-GDF15、GS200L23-GDF15、GS200L136-GDF15、GS200S14-GDF15。
图9：GS与GDF15融合蛋白对DIO小鼠的体重减轻效果图。
图10：GS与GDF15融合蛋白对DIO小鼠的食欲抑制效果图。
图11：GS与GLP2G融合蛋白的体外细胞活性检测结果图。
图12：GS与ARVEGF融合蛋白的体外细胞活性结果图。
图13：在大鼠血清中温育第7天的GS-GH及rGLK1164-hArg1融合蛋白。1、GS800R9-GH-GS100R9；2、GS800R35-GH-GS100R35；3、GS800R127-GH-GS100R127；4、GS800L91-GH-GS100L91；5、GS800L102-GH-GS100L102；6、GS800L146-GH-GS100L146；7、rGLK1164-hArg1；8、GS800S203-GH-GS100S203。
图14：GS-GH融合蛋白及hGH在胰酶中的稳定性结果图。A.泳道1-4分别为hGH在0、0.02％、0.1％、0.5％的胰酶中孵育40min的结果；M为低分子量MARKER:97.2KD、66.4KD、44KD、29KD、21KD及14KD。B.泳道1和2：GS800R9-GH-GS100R9；泳道3和4：GS800R35-GH-GS100R35；泳道5和6：GS800R127-GH-GS100R127；泳道7和8：GS800L91-GH-GS100L91；泳道9和10：GS800L102-GH-GS100L102；泳道11和12：GS800L146-GH-GS100L146；泳道13和14：GS800S203-GH-GS100S203。M为高分子量MARKER:220KD、135KD、90KD、66KD、45KD及35KD。
具体实施方式
应理解，在本发明范围中，本发明的上述各技术特征和在下文(如实施例)中具体描述的各技术特征之间都可以互相组合，从而构成优选的技术方案。
术语
本文中，“生物活性蛋白/多肽”指的是蛋白质、抗体、多肽及其片段和变异体，具有一种或者多种药理学和/或生物学活性或功能(如本文所述的药代动力学和理化性质)，或靶向引导，多聚化等功能。它们可以是天然就存在的，也可以是人工构建的。“生物活性蛋白/多肽”可包括酶、酶抑制剂、抗原、抗体、激素、凝血因子、干扰素、细胞因子、生长因子、分化因子、骨组织生长有关的因子、与骨质因子吸收相关的因子，趋化因子、细胞运动因子、移动因子、静止因子、杀(细)菌因子、抗真菌因子、血浆黏附分子、间质黏附分子和细胞外基质、受体配基及其片段等。
在某些实施方案中，本发明的“生物学活性”或“生物活性”表现为“治疗活性”。因此，在这些实施方案中，本发明所涉及的生物学活性蛋白/多肽为表现出“治疗活性”的蛋白/多肽，这种蛋白/多肽拥有一种或者多种已知的生物和/或治疗活性。这些活性与一种或多种本文描述的或者其他已知的治疗蛋白相关。作为一个非限制性例子，“治疗蛋白”(在本文中可与“治疗性蛋白”或“活性蛋白药物”互换)是指一种对于治疗、预防或者改善疾病、症状或者机能紊乱有用的蛋白。作为一个非限制性例子，“治疗蛋白”可以是一种特异性地结合到特定细胞类型(例如淋巴细胞或者癌细胞)并且定位于该细胞表面(或随后内吞至胞内)的蛋白。在另外的非限制性例子中，“治疗蛋白”是指有生物活性的蛋白，特别是一种对于治疗、预防或改善疾病有用的生物活性蛋白。非限制性的治疗蛋白包括拥有以下生物活性的蛋白：如增加血管新生、抑制血管新生、调节造血功能、促进神经发育、提高免疫反应、抑制免疫反应等。
正如上述提及中的一样，“治疗活性”或者“活性”可以指在人类、非人哺乳动物或其他种属生物体中得到与理想的治疗结果一致的效果的活性。治疗活性可以在体内或者体外测量。
本发明所述的“治疗蛋白”可包括但并不限于：VEGF受体或其片段，TNF受体，HER-2/神经膜受体，人ErbB3受体分泌形态异构体，转化生长因子bⅢ型受体胞外区，转化生长因子bⅡ型受体胞外区，IL-1受体，IL-4受体，尿激酶，β-葡糖脑苷脂酶，精氨酸脱亚胺酶，Arginase，herstatin，表皮生长因子，FGF-1，FGF-19，FGF-21，纤维原细胞生长因子-2，普通纤维细胞生长因子，神经生长因子，血小板来源生长因子，VEGF-1，IL-1，IL-2，IL-3，IL-4，IL-6，IL-8，IL-10，IL-11，IL-12，IL-15，IL-18，IL-21，IL-24，IL-1RA，RANKL，RANK，OPG，LEPTIN，干扰素α，干扰素β，干扰素γ，干扰素Ω，TGF-β，TGF-β-1，TGF-β-3，TNFα，心房钠尿肽，B型钠尿肽，促性腺激素，人黄体生成素，促卵泡激素，人生长激素，EPO，G-CSF，GM-CSF，TPO，M-CSF，SCF，VEGF，EPO模拟肽，TPO模拟肽，FLT3配体，Apo2配体，骨细胞抑止因子，BMP-2，BMP-7，GLP-1及其类似物，GLP-2及其类似物，Exendin-3，Exendin-4及其类似物，胰岛素及其类似物，GIP及其类似物，胰高血糖素及其类似物，内皮抑制素(endostatin)，plasminogen kringle 1 domain，plasminogen kringle 5 domain和血管抑素等。治疗性蛋白也还可以是抗体及其片段，尤其是抗原结合片段，包括单链抗体scFv等。这些蛋白以及编码这些蛋白的核酸序列都是大家熟知的，并且在如Chemical Abstracts ServicesDatabases(例如CAS Registry)、GenBank和GenSeq这样的公共数据库中可以找到。对于本领域技术人员来说，根据本发明的精神，容易理解的是现有已经发现的绝大部分生物活性蛋白都适用于本发明。当然，同样应理解的是，在本发明以后新发现的具有生物学活性的蛋白/多肽也同样适用于本发明。
本文中，“凝胶化”指某些溶液在冷却时会逐渐变得粘稠，最后失去流动性而成为具有弹性的胶冻，这种现象叫做凝胶化现象。通过天然胶原水解获得的明胶具有某些特定的性质，水溶液中明胶性质受温度、pH、制作工艺及浓度等的影响。其中，对温度产生可逆转的凝胶化是明胶最重要的一种性质(GELATIN HANDBOOK，GMIA，2012)。
本文中，“PEG”和/或“PEG化”指将聚乙二醇(PEG)聚合物链共价连接至目的生物活性蛋白上。将PEG共价连接至生物活性蛋白能够掩蔽所述蛋白免于宿主的免疫系统攻击，并增加目的生物活性蛋白的水动力学半径，从而通过降低肾清除率来延长该蛋白药物的循环时间。
本文中，序列同源性(sequence homology)用来描述物种亲缘关系的远近。如果两条序列有一个共同的进化祖先，那么它们是同源的。对序列同源性进行分析时，一般是将待研究序列加入到一组来自不同物种的多序列中以确定该序列与其他序列的同源关系。常用的分析工具是CLUSTAL等。
本文中，序列同一性(sequence identity)指参与对比的序列中相同残基的百分比。可采用本领域周知的计算软件计算两条或多条目的序列的序列同一性，这些软件可获自如NCBI。
本文中，序列相似性(sequence similarity)指若干条DNA、RNA或蛋白序列之间的相似程度，理解为参与对比的序列中相同残基的百分比(同一性百分比，identity％)或具有相似物理化学性质的残基百分比(相似性百分比，similarity％)。例如，2条不同蛋白质序列的序列相似性可以理解为此2条序列中存在的相同氨基酸残基的百分比(同一性百分比，identity％)或者此2条蛋白质序列中存在的具有相似物理化学性质的氨基酸残基的百分比(相似性百分比，similarity％)。
除上述术语外，对于本文中使用到的其它术语，除非另有说明，否则其含义为本领域的通用含义。
类明胶单元(U)
本发明公开提供一种类明胶单元(U)，构成该类明胶单元的氨基酸种类由甘氨酸(G)、脯氨酸(P)、丙氨酸(A)和谷氨酸(E)组成，并具有G-X-Y三元单体重复结构，其中G代表甘氨酸(G)，X和Y各自独立选自脯氨酸(P)、丙氨酸(A)或谷氨酸(E)。
在某些实施方案中，本发明的类明胶单元可具有以下重复结构：
(G-X-Y)n
其中，G为甘氨酸，X和Y各自独立选自脯氨酸、丙氨酸或谷氨酸；n为5-20的整数。
在某些实施方案中，所述G-X-Y三元单体重复结构选自：GPP、GEE、GAA、GEA、GAE、GAP、GPA、GPE和GEP。因此，在某些实施方案中，本发明公开的类明胶单元(U)可由选自以下的两种或两种以上的G-X-Y三元单体重复结构组成：GPP、GEE、GAA、GEA、GAE、GAP、GPA、GPE和GEP。
在某些实施方案中，本公开的类明胶单元(U)至少由6个G-X-Y三元单体组成(即n≥6)，如6≤n≤20或6≤n≤15。在某些实施方案中，本公开的类明胶单元(U)至少由9个G-X-Y三元单体组成，如9≤n≤20或9≤n≤15。
通常，基于表达量的优化，相同的G-X-Y三元单体并不连续出现，以避免潜在的同源重组事件发生。
在某些实施方案中，本发明公开的类明胶单元选自SEQ ID NO:17-89中任一奇数编号的序列所示的类明胶单元。在某些优选的实施方案中，本发明公开的类明胶单元选自SEQ ID NO:17、SEQ ID NO:19、SEQ ID NO:21、SEQ ID NO:25、SEQ ID NO:27、SEQ ID NO:29和SEQ ID NO:31。
类明胶蛋白(GS)
进一步地，本文提供一种包括至少两个本文所述类明胶单元(U)的类明胶蛋白(GS)。本文的类明胶蛋白可用作载体蛋白，用于承载生物活性蛋白，尤其是活性蛋白药物。
在某些实施方案中，本文所述的类明胶蛋白的核心结构为：U1-U2或U1-U2-…Ua，其中，U1、U2、…、Ua各自代表本文任一实施方案所述的任意一种类明胶单元，a为≥3的整数。本发明类类明胶蛋白中的各类明胶单元可相同或不同。在某些实施方案中，3≤a≤150；在某些实施方案中，3≤a≤100；在某些实施方案中，3≤a≤50。应理解，a的选择应使得本文所述的类明胶蛋白的氨基酸残基总数在下文任意实施方案所述的范围内。除核心结构外，本文所述类明胶蛋白可含有其它不影响到该类明胶蛋白的生物学性质(包括但不限于下文所述的凝胶化、粘度、产物均一性、血清稳定性、耐酶稳定性和免疫原性等)的氨基酸序列。例如，该类明胶蛋白N-末端、C-末端和/或蛋白内的合适区域内可含有采用重组技术生产该类明胶蛋白时为促进其表达、分泌到宿主细胞外和/或纯化而使用的氨基酸序列，包括但不限于适合的接头序列、信号肽、前导肽、末端延伸等。在某些实施方案中，所述氨基酸序列为蛋白标签，可以是FLAG、HA、Poly-His、GST、MBP和c-Myc等。这些标签可用于对蛋白进行纯化。在某些实施方案中，所述核心结构的氨基酸残基总数占该类明胶蛋白氨基酸残基总数的70％以上，较佳80％以上，更佳85％以上，进一步更佳90％以上、95％以上或99％以上。在某些实施方案中，本发明的类明胶蛋白由本文任一实施方案所述的类明胶单元组成。
优选地，本文的类明胶蛋白中Ala的含量大于等于10％；更优选地，Ala的含量大于等于12％；更优选地，Ala的含量大于等于15％；更优选地，Ala的含量大于等于18％；更优选地，氨基酸Ala的含量大于等于20％。优选地，氨基酸Ala的含量不超过45％，例如不超过40％、不超过35％或不超过30％等。因此，在某些实施方案中，本发明GS中Ala的含量在上述列出的任意两个数值作为端点构成的范围之内，如在10-45％的范围内，如12-45％、15-45％、18-45％、20-45％或10-40％、10-30％、10-20％或15-45％等。
根据代表亲水性的GRAVY值(Kyte J.,Doolittle R.F.，J.Mol.Biol.157:105-132，1982)划分，氨基酸Ala为1.800，Glu为-3.500，Pro为-1.600，Gly为-0.400。即Ala为疏水性氨基酸，Glu、Pro和Gly为亲水性氨基酸。在某些实施方案中，根据ProtParam公式计算，本文所述的类明胶蛋白(GS)代表亲水性的GRAVY值大于-1.1；优选地，该GRAVY值大于等于-1.0；更优选地，该GRAVY值大于等于-0.9；更优选地，该GRAVY值大于等于-0.8。优选地，该GRAVY值最大为0，如最大为-0.1或最大为-0.2。因此，在某些实施方案中，本文所述的类明胶蛋白(GS)代表亲水性的GRAVY值在上述任意两个数值作为端点构成的范围之内，如大于-1.1到≤0的范围内，如大于-1.1到-0.1、-1.0到0、-0.9到0、-0.8到0或-0.8到-0.1等。在某些实施方案中，本文所述的类明胶蛋白(GS)代表亲水性的GRAVY值在-1.0到0.0之间。
因此，本文所述的类明胶蛋白通常具有以下特征：(1)含有本文所述的类明胶单元；(2)Ala的含量大于等于10％，优选大于等于12％，更优选大于等于15％，更优选大于等于18％，更优选大于等于20％，优选Ala含量≤45％，如≤40％或小于等于35％；和(3)代表亲水性的GRAVY值大于-1.1，优选大于等于-1.0，更优选大于等于-0.9，更优选大于等于-0.8，优选该值≤0，如≤-0.1或≤-0.2。
通常，本文所述的类明胶蛋白(GS)具有至少100个氨基酸，优选具有至少200个氨基酸，更优选具有至少300个氨基酸，更优选具有至少400个氨基酸，更优选具有至少500个氨基酸，更优选具有至少600个氨基酸，更优选具有至少700个氨基酸，更优选具有至少800个氨基酸，更优选具有至少900个氨基酸，更优选具有至少1000个氨基酸，更优选具有至少1200个氨基酸。在某些实施方案中，本文所述的类明胶蛋白具有100-2000个氨基酸，例如200-2000、300-2000、400-2000、500-2000、600-2000、700-2000、800-2000、900-2000、1000-2000或1200-2000个氨基酸。
在某些优选的实施方案中，本文所述的类明胶蛋白由相同序列的类明胶单元(U)通过重复拼接而成。在其它优选的实施方案中，本文所述的类明胶蛋白由不同的类明胶单元(U)拼接而成。在某些实施方案中，各类明胶单元之间可存在接头序列，如由含有甘氨酸(G)和/或脯氨酸(P)的氨基酸序列形成的接头序列。
在某些优选的实施方案中，示例性的本发明类明胶蛋白选自SEQ ID NO:91-185中任一奇数编号所示的序列。在某些优选的实施方案中，可将选自SEQ ID NO:91-185中奇数编号所示的序列中的任意两条或任意多条(如2-20条，或2-10条，或2-8条)拼接形成本发明的类明胶蛋白。因此，在这些实施方案中，本发明的类明胶蛋白含有2-20条选自SEQ ID NO:91-185中任一奇数编号所示的序列。优选地，用于拼接形成本发明类明胶蛋白的两条或多条所述序列为相同的序列。同样地，各拼接序列之间可之间连接，或者可通过本领域周知的接头序列(如由含有甘氨酸(G)和/或脯氨酸(P)的氨基酸序列形成的接头序列)相连。在某些优选的实施方案中，示例性的本发明类明胶蛋白选自SEQ ID NO:211-239、247-259和263-309中任一奇数编号的序列所示的融合蛋白中所包含的类明胶蛋白，包括但不限于SEQID NO:231第1-231位氨基酸残基序列(GS200R9)、SEQ ID NO:239第1-573位氨基酸残基序列(GS500R9)、SEQ ID NO:263第1-915位氨基酸残基序列(GS800R9)、SEQ ID NO:265第1-864位氨基酸残基序列(GS800R35)、SEQ ID NO:267第1-864位氨基酸残基序列(GS800R127)、SEQ ID NO:269第1-864位氨基酸残基序列(GS800L91)、SEQ ID NO:271第1-864位氨基酸残基序列(GS800L102)、SEQ ID NO:273第1-864位氨基酸残基序列(GS800L146)、SEQ ID NO:275第1-915位氨基酸残基序列(GS800S203)、SEQ ID NO:279第1-216位氨基酸残基序列(GS200L23)、SEQ ID NO:281第1-216位氨基酸残基序列(GS200L136)、SEQ ID NO:283第1-231位氨基酸残基序列(GS200S14)、SEQ ID NO:293第1-687位氨基酸残基序列(GS600R9)、SEQ ID NO:295第1-648位氨基酸残基序列(GS600L23)、SEQ ID NO:297第1-648位氨基酸残基序列(GS600L136)、SEQ ID NO:299第1-687位氨基酸残基序列(GS600S14)、SEQ ID NO:303第34-948位氨基酸残基序列(GS800S14)、SEQ ID NO:305第34-948位氨基酸残基序列(GS800S203)和SEQ ID NO:309第1-1029位氨基酸残基序列(GS900R9)。在某些实施方案中，本文所述的类明胶蛋白的氨基酸序列为与此段提及的任一氨基酸序列具有80％以上同一性百分比、优选85％以上同一性百分比、更优选90％以上同一性百分比、更优选95％以上同一性百分比的氨基酸序列。
绝大部分治疗用生物活性蛋白，因其具有高级构象，因此一般都需要低温储存。因此作为生物活性蛋白的载体蛋白而言，在低温及常温下均需要有极好的溶解度和较低的粘度。如果在低温下形成了凝胶状，则溶解度下降，粘度显著增加，对于生物药物制备以及患者的给药都会增加额外障碍。天然的明胶是由动物毛皮、骨骼等结缔组织中的胶原部分通过强酸或强碱水解而成。明胶的性质受温度、pH及浓度的影响很大。天然明胶易溶于热水(>40℃)并在低温下趋于形成胶状。另外，当水溶液中的明胶浓度高于0.5％时，在35-40℃的温度下粘度首先会提高，进而形成胶状(Gelatin handbook,Gelatin ManufacturersInstitute of America,2012)。ZL200980103870.9及Werten MW等(Werten MW等,Secretedproduction of a custom-designed,highly hydrophilic gelatin in Pichiapastoris.Protein Eng.14(6):447-54.2001)分别报道了人工设计的重组表达制备的类明胶蛋白。然而本文的实施例显示，取自ZL200980103870.9的GLK序列其理化性质对于温度的变化非常敏感，即这些类明胶样的序列虽然经过重组表达，但是很大程度上仍然保留了天然明胶的凝胶化性质。此外，在保持G-X-Y三元单体结构的基础上，类明胶蛋白的氨基酸种类越多，其凝胶化的性质越接近天然明胶，即越容易受温度的影响而凝胶化。如本文实施例所示，氨基酸种类超过4个的蛋白都带有凝胶化的性质。而当X和Y分别独立地选自脯氨酸(P)、丙氨酸(A)或谷氨酸(E)时，则可大幅地消除凝胶化的性质，粘度显著降低。
另外，除静脉输注以外，皮下注射、肌肉注射、玻璃体注射等注射给药途径，对于给药容量都有限制。例如眼科玻璃体给药，注射部位超过100微升就会导致眼压升高，需要通过玻璃体引流等来降低眼压；皮下注射的最大给药容量一般不超过2毫升，如果超出则需要进行多部位注射。更大的给药体积往往意味着给药途径的负担加重，增加患者的痛苦。为了减少给药体积，很多时候需要将药品制剂制备成较高浓度。因此，在常温下粘度高对于蛋白药物是一个严重的缺陷；作为载体蛋白，除了免疫原性低，无其他生理学活性外，很重要的一个条件是溶解度高，粘度低。
但是，现有的载体蛋白，如取自ZL200980103870.9的GLK与活性蛋白融合而成的重组融合蛋白，在25℃下或者在浓度高于10mg/ml时，凝胶化现象已经开始显现，而且粘度较大，并不适合临床应用，即并不适合作为蛋白药物载体。
与现有载体蛋白不同的是，本发明提供的类明胶蛋白(GS)不仅无明显凝胶化的现象，而且粘度极低，是一种更为理想的蛋白药物载体。在某些实施方案中，采用冻力测试仪，按照国家标准《食品添加剂明胶》GB6783－94方法测定得到的本发明类明胶蛋白的凝冻强度≤10g，优选≤5g，更优选≤3g。例如，本发明类明胶蛋白的凝冻强度可在1-10g之间，或在1-5g或1-3g之间。在某些实施方案中，采用ND-2勃氏粘度，按照国家标准《食品添加剂明胶》GB6783－94方法测定得到的本发明类明胶蛋白的粘度≤3mPa·s，优选≤2mPa·s，更优选≤1mPa·s。例如，在某些实施方案中，本发明类明胶蛋白的粘度在0.01-3mPa·s的范围内，优选在0.05-1mPa·s的范围内。
XTEN为一种由6种氨基酸(A，E，G，P，S，T)组成的多肽，其中8％A，12％E，18％G，17％P，28％S和17％T(Volker Schellenberger等，A recombinant polypeptide extendsthe in vivo half-life of peptides and proteins in a tunable manner，NatureBiotechnology.，27(12):1186，2009)，富含S和T。PAS由脯氨酸(P)、丙氨酸(A)和丝氨酸(S)组成，也富含S。然而，在本发明的研究过程中发现，S和T的加入会导致在真核表达系统中带来严重的糖基化现象。对于某些不适合原核表达系统重组表达、又不适合化学合成的大分子蛋白而言，富含S和T的载体蛋白很难解决糖基化的问题。例如，在本发明的一个实施例中，富含S和/或T的序列在毕赤氏酵母(Pichia pastoris)中表达时，糖基化程度非常高。众所周知，糖基化一般有两种主要类型：O-连接的寡糖糖基化，连接位点在丝氨酸或苏氨酸残基上；N-连接的寡糖糖基化，连接位点在Asn-X-Ser/Thr序列的天冬酰胺酸残基位点上，在此，X可以是除了脯氨酸以外的任意氨基酸。酵母的糖基化系统与人类的不同，高度糖基化尤其是O-糖基化容易产生强免疫原性，而且生产过程批次不均一性问题很难解决。理论上，XTEN、PAS、GLK或者URP等包含大量S或T的序列在原核以外的表达系统中表达时，糖基化严重且不均一都是个极其严峻的问题，能够采取的解决办法只有先在原核表达系统中获得这些序列，再通过化学交联的方式与真核表达系统获得的活性蛋白或多肽(无法或很难在原核表达系统中表达)交联在一起。然而众所周知，化学交联带来的产物不均一，过程繁琐等都是目前无法解决的问题。
另外，有些蛋白或多肽N端的结构与活性密切相关，比如Exendin-4或GLP-1的N端暴露对于其活性至关重要。然而外源蛋白在原核系统(如大肠杆菌E.coli)表达时往往N端带有额外的甲硫氨酸，很难直接获得活性产物。因此一般需要在Exendin-4的N端前面加入融合表达标签，如CBD标签(Volker Schellenberger等，A recombinant polypeptideextends the in vivo half-life of peptides and proteins in a tunable manner，Nature Biotechnology.，27(12):1186，2009)，表达完成后再用TEV蛋白酶进行切割；或者在GLP-1序列前加上其他氨基酸，如两个连续的丙氨酸以提高切割效率(M.Amiram等，Adepot-forming glucagon-like peptide-1fusion protein reduces blood glucose forfive days with a single injection，J Control Release.，172(1):144-51，2013)，只有这样才能获得具有天然生物学活性的GLP-1融合蛋白。而直接用酵母或者细胞表达GLP-1融合蛋白则不需要额外的蛋白酶切就可以直接获得具有天然N端序列的GLP-1活性融合蛋白。
本发明的类明胶蛋白(GS)由甘氨酸(G)、脯氨酸(P)、丙氨酸(A)和谷氨酸(E)组成，无论在原核还是真核表达系统中制备，都不会出现糖基化的问题。另外，GLK由于Asn(N)及Gln(Q)的脱酰胺化造成的不均一现象以及由于氨基酸种类较多导致的潜在蛋白酶位点增多而引起的降解造成的产物不均一等问题在本发明提供的类明胶蛋白(GS)中存在的可能性都极小。如实施例所示，本发明的类明胶蛋白相比GLK具有更优越的血清稳定性和耐酶稳定性。
最后，作为一种载体蛋白，体内免疫原性是最重要的因素。在本发明的免疫原性检测实施例中，在大鼠体内多次给药后，针对rGLK1164(取自中国专利号200980103870.9)的抗体滴度实际上比较高，而本发明提供的类明胶蛋白(GS)则几乎无免疫原性迹象。此结果与该专利实施例4中的结果不一致，推测可能的原因是该专利中采用的是rGLK1164包被(说明书213段)，rGLK1164是极为亲水的序列，作为包被蛋白是极不合适的。因为酶标板与蛋白之间是通过疏水作用而结合，而rGLK1164本身亲水性极高，因而包被的量极少，造成了假阴性的结果。
融合蛋白
本公开进一步提供融合蛋白，其含有生物活性蛋白和本文所述的类明胶蛋白。如前文所述，生物活性蛋白可以是本领域周知的具有一种或者多种药理学和/或生物学活性，或靶向引导，多聚化等功能的蛋白。它们可以是天然就存在的，也可以是人工构建的。生物活性蛋白可包括酶、酶抑制剂、抗原、抗体、激素、凝血因子、干扰素、细胞因子、生长因子、分化因子、骨组织生长有关的因子、与骨质因子吸收相关的因子，趋化因子、细胞运动因子、移动因子、静止因子、杀(细)菌因子、抗真菌因子、血浆黏附分子、间质黏附分子和细胞外基质、受体配基及其片段等。
在某些实施方案中，本文的融合蛋白含有活性蛋白药物(D)和本文所述的类明胶蛋白(GS)。
适用于本文的活性蛋白药物包括但不限于激动剂、受体、配体、拮抗剂、酶和激素。更具体而言，适用于本文的活性蛋白药物可以是本领域周知的在各种疾病的治疗和/或预防和/或症状的改善中使用到的活性蛋白药物，这类疾病包括但不限于：代谢相关疾病、心血管疾病、凝血/出血疾病、生长障碍或病症、肿瘤、血管障碍疾病、炎症、自身免疫病症等。更具体而言，所述疾病包括1型糖尿病、2型糖尿病、妊娠糖尿病、高胆固醇血症、肥胖症、高血糖症、超高胰岛素血症、胰岛素产生减少、胰岛素抗性、代谢紊乱、多囊卵巢综合征、血脂异常、进食障碍、高血压(如肺性高血压)、视网膜神经变性、代谢紊乱、胰高血糖素瘤、溃疡性结肠炎、肾衰竭、充血性心力衰竭、肾病综合征、肾病、腹泻、术后倾倒综合征、肠易激综合征、危重病性多神经病、全身炎症反应综合征、血脂异常、中风、冠心病、血友病、成人和儿童的GH缺乏、Turner综合征、慢性肾衰竭、宫内发育迟缓、特发性身材矮小、AIDS消耗、肥胖症、多发性硬化、衰老、纤维肌痛、克罗恩病、溃疡性结肠炎、肌营养不良症、低骨密度等。在某些实施方案中，本文所述的活性蛋白药物为前文所述的治疗性蛋白。
生物活性蛋白(尤其是活性蛋白药物)与类明胶蛋白可以本领域周知的方式串联融合。例如，生物活性蛋白融合在类明胶蛋白的N端或C端，或类明胶蛋白融合在生物活性蛋白的两端，又或者生物活性蛋白融合在类明胶蛋白的两端。融合蛋白中可含有两种或两种以上的生物活性蛋白，该生物活性蛋白可相同也可不同。同样地，融合蛋白中也可含有两种或两种以上的类明胶蛋白，该类明胶蛋白可相同也可不同。当含有两种或两种以上生物活性蛋白和/或两种或两种以上的类明胶蛋白时，生物活性蛋白与类明胶蛋白之间的串联方式可以是多样的。示例性的串联融合包括，但不限于如下结构：
D-GS；
GS-D；
D1-GS-D2；
GS1-D-GS2；
GS1-D1-GS2-D2-GS3-D3；
GS1-D1-D2-GS2-D3；
GS1-D1-GS2-D2-D3；
GS1-D1-GS2-D2-D3-GS3；
D1-GS1-D2-GS2-D3；
GS1-D1-GS2-D2-GS3-D3-GS4-D4；
D1-GS1-D2-GS2-D3-GS3-D4-GS4；
其中D1、D2、D3、D4为活性蛋白药物，D1、D2、D3、D4之间可以相同或不相同；GS1、GS2、GS3、GS4为类明胶蛋白(GS)，GS1、GS2、GS3、GS4之间可以相同或不相同。
通常，在融合蛋白中存在两种或两种以上生物活性蛋白和/或两种或两种以上GS时，所述生物活性蛋白之间通常通过GS相连，所述GS之间通常也不直接相连，而是通过生物活性蛋白相连。在某些实施方案中，本文优选使用下表1所列的活性蛋白药物或其类似物。
表1
Figure BDA0001827374440000151
Figure BDA0001827374440000161
在融合了本文所公开的类明胶蛋白(GS)后，生物活性蛋白，尤其是活性蛋白药物(D)的理化性质显著改善，表现为水溶性的提高、耐酶及耐热稳定性的提高，水动力学半径的增大等，这些理想的性质使得生物活性蛋白的体内半衰期显著延长。在本发明某些实施例中，融合蛋白的半衰期比未融合时延长了10倍以上。
应理解，在基因克隆操作中，常常需要设计合适的酶切位点，这势必在所表达的氨基酸序列末端引入了一个或多个不相干的残基，而这并不影响目的序列的活性。为了构建融合蛋白、促进重组蛋白的表达、获得自动分泌到宿主细胞外的重组蛋白、或利于重组蛋白的纯化，常常需要将一些氨基酸(例如，包括但不限于，适合的接头肽、信号肽、前导肽、末端延伸等)添加至重组蛋白的N-末端、C-末端和/或该蛋白内的其它合适区域内。因此，本文融合蛋白的氨基端和/或羧基端还可含有一个或多个多肽片段，作为蛋白标签。任何合适的标签都可以用于本文。例如，所述的标签可以是FLAG、HA、Poly-His、GST、MBP、c-Myc，这些标签可用于对蛋白进行纯化。
此外，在生物活性蛋白与GS之间、两个生物活性蛋白之间甚至两个GS之间可设有合适的接头序列，如含有G(甘氨酸)和/或S(丝氨酸)的接头序列。任何本领域周知的接头序列都可用于本文的融合蛋白。
优选的实施方案中，本文融合蛋白中的类明胶蛋白可选自SEQ ID NO:91-185中任一奇数编号的序列所示的序列，以及SEQ ID NO:231第1-231位氨基酸残基序列(GS200R9)、SEQ ID NO:239第1-573位氨基酸残基序列(GS500R9)、SEQ ID NO:263第1-915位氨基酸残基序列(GS800R9)、SEQ ID NO:265第1-864位氨基酸残基序列(GS800R35)、SEQ ID NO:267第1-864位氨基酸残基序列(GS800R127)、SEQ ID NO:269第1-864位氨基酸残基序列(GS800L91)、SEQ ID NO:271第1-864位氨基酸残基序列(GS800L102)、SEQ ID NO:273第1-864位氨基酸残基序列(GS800L146)、SEQ ID NO:275第1-915位氨基酸残基序列(GS800S203)、SEQ ID NO:279第1-216位氨基酸残基序列(GS200L23)、SEQ ID NO:281第1-216位氨基酸残基序列(GS200L136)、SEQ ID NO:283第1-231位氨基酸残基序列(GS200S14)、SEQ ID NO:287第1-432位氨基酸残基序列(GS400L23)、SEQ ID NO:289第1-432位氨基酸残基序列(GS400L136)、SEQ ID NO:291第1-459位氨基酸残基序列(GS400S14)、SEQ ID NO:293第1-687位氨基酸残基序列(GS600R9)、SEQ ID NO:295第1-648位氨基酸残基序列(GS600L23)、SEQ ID NO:297第1-648位氨基酸残基序列(GS600L136)、SEQ ID NO:299第1-648位氨基酸残基序列(GS600S14)、SEQ ID NO:303第34-948位氨基酸残基序列(GS800S14)、SEQ ID NO:305第34-948位氨基酸残基序列(GS800S203)和SEQ IDNO:309第1-687位氨基酸残基序列(GS900R9)，或为与本段所述任一氨基酸序列具有80％以上同一性百分比、优选85％以上同一性百分比、更优选90％以上同一性百分比、更优选95％以上同一性百分比的氨基酸序列。
本发明示例性的融合蛋白选自SEQ ID NO:211-239、247-259和263-309中任一奇数编号的序列所示的融合蛋白，或为与这些融合蛋白中的任意一种融合蛋白具有80％以上同一性百分比、优选85％以上同一性百分比、更优选90％以上同一性百分比、更优选95％以上同一性百分比的融合蛋白。
本发明类明胶蛋白(GS)在与生物活性蛋白或多肽融合后，能够增强生物活性蛋白或多肽的药代动力学性质，融合该类明胶蛋白(GS)的生物活性蛋白或多肽半衰期可以至少延长2倍以上，其中药物代谢动力学性质通过测定施用于受试者的生物活性蛋白的终末半衰期与施用了相当剂量的融合了类明胶蛋白(GS)的生物活性蛋白相比较来确定。能够起到延长体内半衰期的作用，其本质是由于类明胶蛋白(GS)的水合半径极大，与相同分子量的常规球形蛋白相比，类明胶蛋白(GS)由于充分伸展，尺寸能到达纳米级别。在本发明的一个实施例中(结果如图1和2所示)，分子量约为140KD的GS100R9-hArg1的表观分子量介于669KD与440KD之间；分子量约为170KD的GS100R9-hArg1-GS100R9及GS100R35-hArg1-GS100R35的表观分子量已经大于669KD，而分子量约为220KD的GS200R9-hArg1-GS200R9更是远远大于669KD。
人精氨酸酶1(hArg1)是一种天然的三聚体结构，单体分子量约为35KD，三聚体分子量为105KD左右，虽然该分子量已经远超过肾小球的滤过孔径，然而人精氨酸酶1在体内的半衰期却出奇地短，只有数分钟(P.N.Cheng,T.L.Lam,W.M.Lam,S.M.Tsui,A.W.Cheng,W.H.Lo,et al.,Pegylated recombinant human arginase(rhArg-PEG5,000mw)inhibitsthe in vitro and in vivo proliferation of human hepatocellular carcinomathrough arginine depletion,Cancer Res.67(2007)309–317)。目前一般采用PEG化修饰来延长其体内半衰期。在小鼠体内施用PEG-hArg1后，半衰期能延长至63小时。在本发明的一个实施例中，融合了相似氨基酸长度(100个氨基酸左右)且序列不相同的类明胶蛋白(GS)后，hArg1的半衰期显著延长。hArg1的C末端(S-shaped tail)参与三聚体的形成,而让人惊奇的是，在本发明中，在hArg1的C末端融合类明胶蛋白(GS)却毫不影响其形成三聚体。而且只在hArg1的一端融合类明胶蛋白(GS)或者在两端皆融合类明胶蛋白(GS)都可观察到明显的药代动力学性质的改善，而且在类明胶蛋白(GS)长度相同的情况下，两端皆融合类明胶蛋白(GS)时半衰期更长。
在本发明的另一个实施例中，采用了人生长激素(hGH)来验证类明胶蛋白(GS)改善药代动力学性质的功能；在本发明的另一个实施例中，采用了生长分化因子15(GDF15)来验证类明胶蛋白(GS)改善药代动力学性质的功能；在本发明的另一个实施例中，采用了能结合VEGF的人工设计锚定蛋白(Designed ankyrin repeat proteins)来验证类明胶蛋白(GS)改善药代动力学性质的功能；在本发明的另一个实施例中，采用了GLP2G来验证类明胶蛋白(GS)改善药代动力学性质的功能。在这些实施例中，尽管采用的类明胶蛋白(GS)序列不同，但是这些类明胶蛋白(GS)在延长体内半衰期的作用都是类似的，而且效果都与长度成正比。与同样长度的GLK相比，类明胶蛋白(GS)延长半衰期的效果更显著。
此外，融合了类明胶蛋白(GS)的生物活性蛋白具有显著提升的溶解度和稳定性，比如热稳定性、耐酶稳定性和血清稳定性。在本发明的一个实施例中，融合了类明胶蛋白(GS)的GH蛋白在85℃下的热稳定性明显高于未融合的GH。而且GH容易在制备过程中产生聚集，但是融合了类明胶蛋白(GS)后，在SEC-HPLC上并无观察到显著的聚集现象。另外，通过测定生物活性蛋白暴露于37℃下7天保持的完整性来判断其潜在的人体循环稳定性。如图13WB结果所示，GS融合蛋白在血清中高度稳定，而对照的rGLK1164-Arg1蛋白已经呈现被降解的弥散状。
具有治疗活性的化学偶联物
抗体-药物偶联物(ADC)是抗体与毒性化合物或放射性核素通过赖氨酸、半胱氨酸、非天然氨基酸及工程构建的标签等制备获得的治疗药物。作为ADC药物的一个突出缺点是，由于高疏水性毒性化合物或放射性核素的交联导致整个ADC分子容易聚集甚至产生不可溶的沉淀，尤其是当药物/抗体比率(DAR)较高的情况下。为了解决这个问题，可以通过将化学合成的高亲水聚乙二醇(PEG)或者可生物降解的短链分子作为连接链(Linker)，如PHF(或称
Figure BDA0001827374440000181
)。这些手段能有效地改善ADC分子的亲水性并增加其稳定性。
同样地，当具有治疗活性的蛋白分子量极小或者为不适合重组表达的多肽时，优选地可采用化学交联的方式。在本公开中，具有治疗活性的蛋白可由若干不同的活性蛋白药物(D)和类明胶蛋白(GS)通过化学交联的方式制备而成。化学交联可以在大部分氨基酸残基上进行，例如赖氨酸上亲核型的伯胺基团和半胱氨酸上的活性巯基是最常用的交联位点。此外，酪氨酸和硒代半胱氨酸也会被用于化学交联。
多核苷酸序列、核酸构建体和宿主细胞
本文包括编码本文提供的各种类明胶单元、类明胶蛋白以及融合蛋白的编码序列及其互补序列。示例性的类明胶单元的编码序列如SEQ ID NO:18-90中任一偶数编码的序列所示；示例性的类明胶蛋白的编码序列如SEQ ID NO:92-186中任一偶数编码的序列所示，或者如SEQ ID NO:212-240、248-260和264-310中任一偶数编号的序列所示的融合蛋白编码序列中所包含的类明胶蛋白的编码序列；示例性的融合蛋白的编码序列如SEQ ID NO:212-240、248-260和264-310中任一偶数编号的序列所示。可采用本领域常规的方法制备得到所述多核苷酸序列。例如，可先通过基因合成法获得小片段的类明胶蛋白单元(U)片段，再通过基因拼接法获得更大分子量的由该类明胶蛋白单元(U)重复拼接而成的类明胶蛋白(GS)。
本文还包括核酸构建体。核酸构建体是可以被引入靶细胞或组织中的人工构建的核酸区段。该核酸构建体含有本文所述的编码序列或其互补序列，以及与这些序列操作性连接的一个或多个调控序列。调控序列可以是合适的启动子序列。启动子序列通常与待表达氨基酸序列的编码序列操作性连接。启动子可以是在所选择的宿主细胞中显示转录活性的任何核苷酸序列，包括突变的、截短的和杂合启动子，并且可以从编码与该宿主细胞同源或异源的胞外或胞内多肽的基因获得。调控序列也可以是合适的转录终止子序列，由宿主细胞识别以终止转录的序列。终止子序列与编码该多肽的核苷酸序列的3’末端相连，在选择的宿主细胞中有功能的任何终止子都可用于本文。
在某些实施方案中，所述核酸构建体是载体。具体而言，可将本文所述的编码序列，尤其是类明胶蛋白或融合蛋白克隆入许多类型的载体，这些类型的载体包括但不限于质粒、噬菌粒、噬菌体衍生物、动物病毒和粘粒。载体可以是表达载体，或者是克隆载体。
通常，合适的载体包含在至少一种有机体中起作用的复制起点、启动子序列、方便的限制酶位点和一个或多个可选择的标记。这些启动子的代表性例子有：大肠杆菌的lac或trp启动子；λ噬菌体PL启动子；真核启动子包括CMV立即早期启动子、HSV胸苷激酶启动子、早期和晚期SV40启动子、毕赤酵母的甲醇氧化酶启动子和其它一些已知的可控制基因在原核或真核细胞或其病毒中表达的启动子。标记基因可用于提供用于选择转化的宿主细胞的表型性状，包括但不限于真核细胞培养用的二氢叶酸还原酶、新霉素抗性以及绿色荧光蛋白(GFP)，或用于大肠杆菌的四环素或氨苄青霉素抗性。当本文所述的多核苷酸在高等真核细胞中表达时，如果在载体中插入增强子序列，则将会使转录得到增强。增强子是DNA的顺式作用因子，通常大约有10到300个碱基对，作用于启动子以增强基因的转录。
本领域一般技术人员清楚如何选择适当的载体、启动子、增强子和宿主细胞。可采用本领域技术人员熟知的方法构建含本文所述的多核苷酸序列和合适的转录/翻译控制信号的表达载体。这些方法包括体外重组DNA技术、DNA合成技术、体内重组技术等。
本文还包括包含本文所述多核苷酸序列、其核酸构建体，和/或表达含有本文所述类明胶单元(尤其是本文所述类明胶蛋白)的氨基酸序列的宿主细胞。宿主细胞可以是原核细胞，如细菌细胞；或是低等真核细胞，如酵母细胞；丝状真菌细胞、或是高等真核细胞，如哺乳动物细胞。代表性例子有：大肠杆菌，链霉菌属；鼠伤寒沙门氏菌的细菌细胞；真菌细胞如酵母、丝状真菌、植物细胞；果蝇S2或Sf9的昆虫细胞；CHO、COS、293细胞、或Bowes黑素瘤细胞的动物细胞等。
可采用常规的方法将本文的载体导入宿主细胞中，这些方法包括显微注射法、基因枪法、电穿孔法、病毒介导的转化法、电子轰击法、磷酸钙沉淀法等。
药物组合物
本文提供含有本文所述融合蛋白的药物组合物。药物组合物中还可含有本领域周知的各种合适的药学上可接受的载体或赋形剂。药学上可接受的载体或赋形剂在所采用的剂量和浓度对接受者是无毒的，包括但不限于：缓冲剂，如乙酸盐、Tris、磷酸盐、柠檬酸盐和其它有机酸；抗氧化剂，包括抗坏血酸和甲硫氨酸；防腐剂(如氯化十八烷基二甲基苄基铵；氯己双铵；苯扎氯铵、苄索氯铵；酚、丁醇或苄醇；对羟基苯甲酸烃基酯，如对羟基苯甲酸甲酯或对羟基苯甲酸丙酯；邻苯二酚；间苯二酚；环己醇；3-戊醇；和间甲酚)；蛋白质，如血清清蛋白、明胶或免疫球蛋白；亲水性聚合物，诸如聚乙烯吡咯烷酮；氨基酸，如甘氨酸、谷氨酰胺、天冬酰胺、组氨酸、精氨酸或赖氨酸；单糖、二糖和其它碳水化合物，包括葡萄糖、甘露糖或糊精；螯合剂，如EDTA；张力调节剂，诸如海藻糖和氯化钠；糖类，诸如蔗糖、甘露醇、海藻糖或山梨醇；表面活性剂，如聚山梨醇酯；成盐抗衡离子，如钠；金属复合物(如Zn-蛋白质复合物)；和/或非离子表面活性剂，如
Figure BDA0001827374440000201
Figure BDA0001827374440000202
或聚乙二醇(PEG)。用于体内施用的药物配制剂一般是无菌的。这易于通过无菌滤膜过滤来实现。
可根据药物组合物的剂型选择合适的药学上可接受的载体或赋形剂。可根据药物组合物的不同用途将其制备成不同的剂型。例如，可将本发明的药物组合物制备成片剂、注射剂、冻干剂等常用剂型。
药物组合物中通常含有治疗或预防有效量的本文所述的融合蛋白。治疗有效量通常指足以显示其对于所施用对象益处的剂量。施用的实际量，以及施用的速率和时间过程会取决于治疗者的自身情况和严重程度。治疗的处方(例如对剂量的决定等)最终是全科医生及其它医生的责任并依赖其做决定，通常考虑所治疗的疾病、患者个体的情况、递送部位、施用方法以及对于医生来说已知的其它因素。预防有效量指在必需的剂量和时间上有效实现期望的预防效果的量。通常而非必然，由于预防剂量是在疾病发作之前或在疾病的早期用于受试者的，因此预防有效量将低于治疗有效量。
方法和用途
本发明的氨基酸序列可以是化学合成的产物，或是使用重组技术从原核或真核宿主(例如，细菌、酵母、丝状真菌、高等植物、昆虫和哺乳动物细胞)中产生的重组多肽。根据重组生产方案所用的宿主，本发明的活性蛋白或多肽部分可以是糖基化的，或可以是非糖基化的。
因此，在某些实施方案中，本文提供一种蛋白治疗药物的制备方法，包括如下步骤：
1)培养含有本文所述融合蛋白的编码序列或其表达载体的宿主细胞，使之表达所述融合蛋白；
2)收集含有所述融合蛋白的培养物；和
3)从所述培养物中分离出所述融合蛋白。
细胞培养方法可根据不同细胞类型加以确定，为本领域常规的培养方法。
在某些实施方案中，本文还提供一种疾病治疗或预防方法，该方法包括给予需要的对象治疗有效量或预防有效量的本文所述的融合蛋白或其药物组合物。所治疗的疾病与该融合蛋白中的生物活性蛋白的生物学活性或功能相关。例如，生长激素(GH)能促进骨骼、内脏和全身生长，促进蛋白质合成，影响脂肪和矿物质代谢，可用于内源性垂体生长激素分泌不足而引起的生长障碍、躯体矮小的侏儒症、矮小病患儿，还可用于治疗烧伤、骨折、创伤、出血性溃疡、肌肉萎缩症、骨质疏松等疾病。因此，当融合蛋白中的活性蛋白药物为GH时，该融合蛋白可用于治疗内源性垂体生长激素分泌不足而引起的生长障碍、躯体矮小的侏儒症、矮小病患儿，还可用于治疗烧伤、骨折、创伤、出血性溃疡、肌肉萎缩症、骨质疏松等疾病。又例如，IL-2对机体的免疫应答和抗病毒感染具有重要作用，临床上用作免疫增强剂，主要用于肾癌、黑色素瘤和非何杰金淋巴瘤。因此，当治疗肾癌、黑色素瘤或非何杰金淋巴瘤患者时，可给予含有IL-2作为活性蛋白药物的本文融合蛋白。又例如，GDF15可用于治疗过度肥胖和体重不足相关疾病。因此，可给予需要的对象含GDF15的本文融合蛋白。
因此，取决于所含有的生物活性蛋白的生物学活性或功能，本文所述的融合蛋白可用于治疗或预防：代谢相关疾病、心血管疾病、凝血/出血疾病、生长障碍或病症、肿瘤、血管障碍疾病、炎症、自身免疫病症等。更具体而言，所述疾病包括1型糖尿病、2型糖尿病、妊娠糖尿病、高胆固醇血症、肥胖症、高血糖症、超高胰岛素血症、胰岛素产生减少、胰岛素抗性、代谢紊乱、多囊卵巢综合征、血脂异常、进食障碍、高血压(如肺性高血压)、视网膜神经变性、代谢紊乱、胰高血糖素瘤、溃疡性结肠炎、肾衰竭、充血性心力衰竭、肾病综合征、肾病、腹泻、术后倾倒综合征、肠易激综合征、危重病性多神经病、全身炎症反应综合征、血脂异常、中风、冠心病、血友病、成人和儿童的GH缺乏、Turner综合征、慢性肾衰竭、宫内发育迟缓、特发性身材矮小、AIDS消耗、肥胖症、多发性硬化、衰老、纤维肌痛、克罗恩病、溃疡性结肠炎、肌营养不良症和低骨密度等。本文包括治疗或预防上述任意一种疾病的方法，包括给予治疗有效量或预防有效量的并含有治疗或预防该疾病的活性蛋白药物的本文所述的融合蛋白。
本文还提供一种增强生物活性蛋白(尤其是活性蛋白药物)的药代动力学性质的方法，所述方法包括在该生物活性蛋白的C端和/或N端融合本文所述的类明胶蛋白的步骤。本文中，药代动力学性质包括但不限于体内半衰期。在某些实施方案中，本文还提供一种提高生物活性蛋白(尤其是活性蛋白药物)理化性质的方法，所述方法包括在该生物活性蛋白的C端和/或N端融合本文所述的类明胶蛋白的步骤。本文中，理化性质包括但不限于水溶性、血清稳定性、耐酶稳定性和热稳定性中的任意一种、任意两种、任意三种或全部四种。上述方法中，生物活性蛋白可以是前文所述的任意一种或多种生物活性蛋白。融合或化学交联的方法为本领域所知。例如，可采用前文所述的融合蛋白的制备方法制备得到所述融合蛋白，从而增强生物活性蛋白的药代动力学性质和/或提高其理化性质。
因此，本文也提供本文所述的类明胶单元或类明胶蛋白在增强生物活性蛋白(尤其是活性蛋白药物)的药代动力学性质和或提高其理化性质中的应用；本文所述的类明胶单元或类明胶蛋白在制备药代动力学增强和/或理化性质提高的生物活性蛋白(尤其是活性蛋白药物)中的应用；本文所述的多核苷酸序列、核酸构建物、宿主细胞和/或融合蛋白在制备药物中的应用。还提供的是用于增强生物活性蛋白(尤其是活性蛋白药物)的药代动力学性质和或提高其理化性质的本文所述的类明胶单元或类明胶蛋白，用于治疗或预防的融合蛋白。
本文首次发现，由甘氨酸、脯氨酸、丙氨酸和谷氨酸组成的蛋白可作为载体蛋白，用于延长生物活性蛋白或多肽半衰期并改善其体内外性质。因此，甘氨酸、脯氨酸、丙氨酸和谷氨酸在制备能改善生物活性蛋白的生物学性质或功能(例如药代动力学和理化性质)的载体蛋白中的应用也包括在本文的范围之内。在某些实施方案中，本文还提供一种制备能改善生物活性蛋白的生物学性质或功能的载体蛋白的方法。该方法可以是化学合成方法，也可以是生物重组方法。该载体蛋白的结构为G-X-Y三元重复结构，其中G为甘氨酸，X和Y各自独立选自脯氨酸、丙氨酸和谷氨酸。更优选地，该载体蛋白为本文任一实施方案所述的类明胶蛋白。
所述化学合成方法可以是本领域周知的各种化学合成方法，包括按照所述载体蛋白的结构将选自甘氨酸、脯氨酸、丙氨酸和谷氨酸中的氨基酸残基依次连接到肽链上，形成具有G-X-Y三元重复结构的所述载体蛋白。化学合成方法通常包括固相合成法和液相合成法，其中固相合成法较常用。固相合成方法包括但不限于Fmoc和tBoc两种常用方法。通常，使用树脂作为不溶性的固相载体，通常从C端(羧基端)向N端(氨基端)逐个将氨基酸连接在肽链上，每个氨基酸连接循环由以下三步反应构成：1)脱保护：被保护的氨基酸必须用一种脱保护溶剂去除氨基的保护基团；2)活化：待连接的氨基酸的羧基被活化剂所活化；和3)偶联：活化的羧基与前一个氨基酸裸露的氨基反应，形成肽键。反复循环直到肽链延伸至所需长度时即可完成。最后用切割液切割肽链和固相载体之间的连接，就可获得所需的氨基酸序列。可以在程序控制的自动化多肽合成仪上进行上述化学合成，这类仪器包括但不限于Protein Technologies公司推出的Tribute双通道多肽合成仪、C S Bio公司的UV OnlineMonitor系统、Aapptec公司推出的Focus XC三通道合成仪等。
生物重组方法包括按照载体蛋白的氨基酸序列制备编码该氨基酸序列的多核苷酸序列，使用该多核苷酸序列构建表达载体，使用该表达载体转化或转染宿主细胞，以及培养宿主细胞以使其表达产生所述载体蛋白。这可采用本领域熟知的技术手段实现。
下述具体的实施方式，如无特别说明，均为本领域技术人员熟知的常规方法。本发明实施例使用的免疫学、生物化学、微生物学、细胞生物学、遗传学和重组DNA的常规技术可以参见如《分子克隆实验指南》第三版(Sambrook J，Russell DW，Molecular cloning：Alaboratory manual.3rd edition，New York：Cold Spring Harkbor Laboratory Press，2001)或商业公司提供的操作说明书中的技术方案。
蛋白纯化的方法根据不同的表达系统有所差异，现有技术早已有大量的知识提供蛋白纯化的指导，如GE Healthcare公司的经典纯化指南手册《Antibody PurificationHandbook》，或者Elsevier出版社出版的《METHODS IN ENZYMOLOGY，Guide to ProteinPurification,2nd Edition》等。亲和层析、分子排阻层析、离子交换层析及疏水层析等纯化工具的原理及使用方法以及组合使用，已是本领域技术人员所熟知的技术。如下实施例中涉及的纯化过程为示例性的表明在表达宿主为甲醇酵母GS115及该特定发酵条件下的纯化方式。当发酵条件不同时，杂质的组分及含量也不相同，纯化条件亦应当相应稍作调整。由于是公知技术，在此不再赘述。但是作为一个普遍的标准，目的蛋白的最终纯度应该超过95％(SDS-PAGE纯度及HPLC鉴定纯度)。
实施例1：类明胶蛋白单元(U)的获得
类明胶单元(U)主要由以下几种G-X-Y三元单体结构组成：GPP、GEE、GAA、GEA、GAE、GAP、GPA、GPE、GEP。不同的G-X-Y三元单体结构任意组合形成类明胶蛋白单元(U)。示例性的组合如表2所示。
表2
Figure BDA0001827374440000241
Figure BDA0001827374440000251
实施例2：高表达的低分子量重组类明胶蛋白(GS)的制备
低分子量重组类明胶蛋白(GS)的获取可通过如下步骤之其一实现：
(1)先设计一段由不同或相同类明胶蛋白单元(U)组成的类明胶蛋白(GS)蛋白序列；再将该类明胶蛋白(GS)的蛋白序列转为DNA序列，并通过基因合成法获得全长DNA。
(2)通过类明胶蛋白单元(U)的对应核苷酸序列拼接而成，如Marc W.T.Werten等(Marc W.T.Werten等，Secreted production of a custom-designed,highlyhydrophilic gelatin in Pichia pastoris，Marc W.T.Werten等，Protein Engineering,Design and Selection,14：447–454，2001)所示，先通过基因合成法获得类明胶蛋白单元(U)的DNA序列，再通过基因拼接法获得更大分子量的由该类明胶蛋白单元(U)重复拼接而成的类明胶蛋白(GS)。示例性的GS序列如表3所示。
比如，一段含有Ux、Uy和Uz的核苷酸序列(简称为Uxyz-1)在合成时5'端加入酵母GS115的α-factor信号肽序列(带Xho I位点)，紧接着为内切酶DraIII的识别位点，3'端则带有Van91I及EcoRI识别位点，并连接在克隆载体pMD18-T(TaKaRa公司)上，构建成质粒pMD-Uxyz-1。
为了获得Uxyz-1的二聚体，首先将质粒pMD-Uxyz-1用Van 91I/Dra III双酶切。1％琼脂糖胶进行电泳，切胶回收Uxyz-1片段。同时，pMD-Uxyz-1质粒用Van91I单酶切。酶切的质粒如上割胶回收，溶于30μL的TE溶液。然后用碱性磷酸酶(Alkaline Phosphatase，BAP)处理。
去磷酸化处理后的pMD-Uxyz-1与Van 91I/Dra III双酶切回收的Uxyz-1片段用T4DNA连接酶按1：10摩尔比进行连接。连接产物转化E.coli DH5α感受态细胞。在转化平板上挑取单克隆至氨苄抗性的LB液体培养基培养，按常规方法提取质粒,用XhoI/EcoRI双酶切鉴定。酶切阳性克隆测序鉴定。此阳性克隆即为二聚体的pMD-UXYZ-2。将UXYZ-1或UXYZ-2片段连接于pMD-Uxyz-2上，即可构建成含3个或4个Uxyz-1片段的目的基因Uxyz-3和Uxyz-4。
同样地，一段含有Ua、Ub和Uc的核苷酸序列(简称为Uabc-1)与Uxyz-1通过上述方法拼接而成Uabcxyz-1，Uabcxyz-1可再拼接成二聚体的Uabcxyz-2或是与其他序列的类明胶蛋白单元(U)拼接，以此类推。
又或者如Martin Schlapschy等人报道(Martin Schlapschy等，Fusion of arecombinant antibody fragment with a homo-amino-acid polymer:effects onbiophysical properties and prolonged plasma half-life，Protein Engineering,Design&Selection，20：273–284,2007)将类明胶蛋白单元(U)通过互补粘端的方式在T4DNA连接酶作用下拼接，再进行琼脂糖凝胶电泳，回收适当大小的DNA片段。同样地，这些参与拼接的类明胶蛋白单元(U)可以是序列相同的，也可以是不同的。为了纯化方便，在类明胶蛋白(GS)的N末端或C末端加入6His亲和纯化标签。
类明胶蛋白(GS)在N端融合6His标签，核苷酸片段亚克隆至质粒pPIC9(LifeTechnologies公司)，构建成表达载体，以甲醇酵母Pichia pastor GS115(His-)为表达宿主菌，通过电转化将线性化的表达质粒转化到GS115中。30℃培养3天，至单菌落出现。将上述转化的重组酵母单菌落接种至10ml BMGY液体培养基中，30℃，250rpm培养24小时后，静置过夜，弃上清，加入10ml含1％甲醇的BMMY液体培养基，30℃，250rpm诱导表达。培养液上清加5×加样缓冲液混匀，100℃加热8-10min。经SDS-PAGE电泳筛选表达菌株。作为经典的理论指南，具体的细节步骤可参见Life Technologies公司的产品手册《PichiaExpression Kit，For Expression of Recombinant Proteins in Pichia pastoris，Catalog no.K1710-01》。值得注意的是，类明胶蛋白(GS)在常规的考马斯亮蓝染色条件下染色效率较低，采用负染方式，比如铜染(Chris Lee等，Analytical Biochemistry 166：308-312，1987)效率更高。具体步骤如下；1、配制0.3M CuCl2水溶液；2、将电泳胶拆下后，用双蒸水漂洗2-3min；3、将胶浸入0.3M CuCl2溶液中，染色2-5min；4、取出胶后，用成像仪拍照。
培养液上清8000rpm离心去沉淀，先用40％硫酸铵沉淀，沉淀用去离子水复溶后，上样到用平衡缓冲液(0.5M NaCl,20mM咪唑,20mM Tris-HCl,pH 7.5)平衡后的50mlChelating Sepharose Fast Flow层析柱(GE Healthcare)，再平衡后用0-100％洗脱缓冲液(0.15M NaCl,0.5M咪唑,20mM Tris-HCl,pH 8.0)线性洗脱。50％洗脱液混合后，加入35％饱和度的硫酸铵沉淀，8000rpm离心20min收集沉淀，用去离子水复溶。
表3示例性地列出了由类明胶单元(U)组成的低分子量类明胶蛋白(GS)及其相应序列。
表3：由类明胶单元(U)组成的低分子量类明胶蛋白(GS)
Figure BDA0001827374440000271
实施例3：凝胶化及粘度测定
粘度以及在水溶液中对温度产生可逆转的凝胶化是天然明胶最重要的性质。当浓度大于0.5％的天然明胶水溶液冷却至约35-40℃时，其首先增加粘度，然后形成凝胶。凝胶的刚性或强度取决于明胶浓度、明胶的固有强度、pH值、温度和添加剂的存在(GELATINHANDBOOK，GMIA，2012)。动物来源的明胶由胶原经酸或碱水解制备而成，分子量分布在20KD-25KD的一般属于低Bloom值、25-50KD的属于中等Bloom值、而50KD-100KD之间的则属于高Bloom值。在检测凝冻强度时，将实施例2中优选的高表达的低分子量类明胶蛋白(GS)制备成二聚体或者通过粘端拼接的方式，使其分子量达到40KD以上，再与天然动物来源的明胶进行比较。作为对比，还同时制备了含4-16种氨基酸组成的GLK。
本实施例参照国家标准《食品添加剂明胶》GB6783－94方法测定样品的凝冻强度及勃氏粘度。先将表4中的GS蛋白纯化样品配制成6.67％(W/W)的水溶液，然后采用冻力测试仪测定凝冻强度，ND-2勃氏粘度测定仪测定粘度。以动物明胶(48722-100G-F，Sigma)为对照。每次测定重复三次，结果如表4所示。
表4结果表明，各种长度和不同序列的GS都没有明显的天然动物明胶性质，而rGLK1164则与天然明胶性质接近。
表4
Figure BDA0001827374440000281
Figure BDA0001827374440000291
实施例4：hArg1融合蛋白的表达
人精氨酸酶1(hArg1)是一种天然的三聚体结构，单体分子量约为35KD，三聚体分子量为105KD左右，虽然该分子量已经远超过肾小球的滤过孔径，然而人精氨酸酶1在体内的半衰期却出奇的短，只有数分钟(P.N.Cheng,T.L.Lam,W.M.Lam,S.M.Tsui,A.W.Cheng,W.H.Lo,et al.,Pegylated recombinant human arginase(rhArg-peg5,000mw)inhibitsthe in vitro and in vivo proliferation of human hepatocellular carcinomathrough arginine depletion,Cancer Res.67(2007)309–317)。目前一般采用PEG化修饰来延长其体内半衰期。
将实施例2中经拼接后的GS片段和对照片段(N端引入6His纯化标签)与人精氨酸酶1(SEQ ID NO:7)融合(如表5所示)，核苷酸片段亚克隆至质粒pPIC9(Life Technologies公司)，构建成表达载体，以甲醇酵母Pichia pastor GS115(His-)为表达宿主菌，通过电转化将线性化的表达质粒转化到GS115中。30℃培养3天，至单菌落出现。将上述转化的重组酵母单菌落接种至10ml BMGY液体培养基中，30℃，250rpm培养24小时后，静置过夜，弃上清，加入10ml含1％甲醇的BMMY液体培养基，30℃、250rpm诱导表达。培养液上清加5倍加样缓冲液混匀，100℃加热8-10min。经SDS-PAGE电泳筛选表达菌株。作为经典的理论指南，具体的细节步骤可参见Life Technologies公司的产品手册《PichiaExpression Kit，ForExpression of Recombinant Proteins in Pichia pastoris，Catalog no.K1710-01》。
表5：示例性的hArg1融合蛋白
融合蛋白代号 氨基酸序列、核苷酸序列(SEQ ID NO:)
GS100R9-hArg1 211、212
GS100R35-hArg1 213、214
GS100R52-hArg1 215、216
GS100R9-hArg1-GS100R9 217、218
GS100R35-hArg1-GS100R35 219、220
GS100R52-hArg1-GS100R52 221、222
GS100R74-hArg1-GS100R74 223、224
GS100R77-hArg1-GS100R77 225、226
GS100R98-hArg1-GS100R98 227、228
GS100R112-hArg1-GS100R112 229、230
GS200R9-hArg1 231、232
GS200R9-hArg1-GS200R9 233、234
GS400R9-hArg1-GS400R9 235、236
GS400R77-hArg1-GS400R77 237、238
GS500R9-hArg1 239、240
GLK<sub>RD</sub>-hArg1 241、242
rGLK116<sub>4</sub>-hArg1 243、244
GEE151-hArg1 245、246
实施例5：hArg1融合蛋白的分离纯化
蛋白纯化的方法根据不同的表达系统有所差异，现有技术早已有大量的知识提供蛋白纯化的指导，如GE Healthcare公司的经典纯化指南手册《Antibody PurificationHandbook》，或者Elsevier出版社出版的《METHODS IN ENZYMOLOGY，Guide to ProteinPurification,2nd Edition》等，亲和层析、分子排阻层析、离子交换层析及疏水层析等，已是本领域技术人员所熟知的技术。如下纯化过程为示例性的表明在表达宿主为甲醇酵母GS115及发酵条件特定情况下的纯化方式。当发酵条件不同时，纯化条件亦应当相应稍作调整，在此不再赘述。
将2L发酵上清用30kDa滤膜超滤浓缩至250mL，浓缩液加入0.5M硫酸铵离心取上清，上清中再加入1.3M硫酸铵离心弃上清，沉淀用1M硫酸铵20mM PB pH6.0复溶，然后上用1M硫酸铵20mM PB pH 6.0缓冲液平衡后的5mL Phenyl Bestarose High Performance层析柱(博格隆(上海)生物技术有限公司)，再平衡后用0-100％20mM PB pH6.0缓冲液洗脱15BV(5mL/min，15min)。洗脱液加入CoCl2至体系中浓度为50mM，于60℃活化10min，离心去除沉淀。上清用20mM NaAc-HAc pH6.0Buffer进行G25脱盐，脱盐后样品pH6.0上1ml SuperQ-650M层析柱(Tosoh BioScience)浓缩0-100％B 20CV洗脱，平衡缓冲液：20mM NaAc-HAc(pH6.0)，洗脱缓冲液：0.5M NaCl+20mM NaAc-HAc(pH6.0)。
当样品经SDS-PAGE鉴定纯度不高于95％时，样品上样到用平衡缓冲液(0.5MNaCl,20mM咪唑,20mM Tris-HCl,pH 7.5)平衡后的50ml Chelating Sepharose Fast Flow层析柱(GE Healthcare)，再平衡后用10％，50％，100％洗脱缓冲液(0.15M NaCl,0.5M咪唑,20mM Tris-HCl,pH8.0)洗脱。
实施例6：G-CSF的融合蛋白制备
将实施例2中经拼接后的GS或GLK片段与G-CSF(SEQ ID NO:9)融合，N端与6His相连(如表6所示)。核苷酸片段亚克隆至质粒pPIC9(Life Technologies公司)，构建成表达载体，以甲醇酵母Pichia pastor GS115(His-)为表达宿主菌，通过电转化将线性化的表达质粒转化到GS115中。30℃培养3天，至单菌落出现。甲醇诱导过程如实施例2所示。培养液上清加5倍加样缓冲液混匀，100℃加热8-10min。经SDS-PAGE电泳筛选表达菌株。作为经典的理论指南，具体的细节步骤可参见Life Technologies公司的产品手册《PichiaExpressionKit，For Expression of Recombinant Proteins in Pichia pastoris，Catalogno.K1710-01》。
发酵液离心上清先用40％硫酸铵沉淀，用去离子水复溶后，上样到用平衡缓冲液(0.5M NaCl,20mM咪唑,20mM Tris-HCl,pH 7.5)平衡后的50ml Chelating SepharoseFast Flow层析柱(GE Healthcare)，再平衡后用0-100％洗脱缓冲液(0.15M NaCl,0.5M咪唑,20mM Tris-HCl,pH 8.0)线性洗脱。50％洗脱液加入35％饱和度的硫酸铵沉淀，8000rpm离心20min收集沉淀，用去离子水复溶。
表6：示例性的G-CSF融合蛋白
融合蛋白代号 氨基酸序列、核苷酸序列(SEQ ID NO:)
GS100R9-GCSF 247、248
GS100R35-GCSF 249、250
GS100R52-GCSF 251、252
GS100R74-GCSF 253、254
GS100R77-GCSF 255、256
GS100R98-GCSF 257、258
GS100R112-GCSF 259、260
rGLK116<sub>4</sub>-GCSF 261、262
实施例7：SEC-HPLC分析GS-Arg1表观分子量
将GS与hArg1融合蛋白1mg/ml样品和分子量标准(gel filtration standardproteins，Agilent)混合溶液，使用SEC-HPLC-UV分析。以相对分子量(Mr)为横坐标，实际测得的洗脱体积(Ve)为纵坐标，线性回归：Ve＝K1-K2logMr。K1与K2为常数，Mr为相对分子质量。分别采用Sepax SRT
Figure BDA0001827374440000321
5μm(300×7.8mm)及Sepax SRT
Figure BDA0001827374440000322
5μm(300×7.8mm)层析柱进行检测，方法如下：检测波长：214nm；柱温25℃，流动相：150mM PB(pH7.0)+5％异丙醇；流速1.0ml/min，运行时间：20分钟。
结果如图1和2所示。从Sepax SRT
Figure BDA0001827374440000323
的结果看，GS100R9-hArg1的表观分子量介于669KD与440KD之间。从Sepax SRT
Figure BDA0001827374440000324
结果来看，GS100R9-hArg1-GS100R9及GS100R35-hArg1-GS100R35的表观分子量已经大于669KD，而GS200R9-hArg1-GS200R9更是远远大于669KD。
实施例8：GS-Arg1体外精氨酸水解活性检测
将待测活GS与hArg1融合蛋白样品(GS-hArg1)和hArg1(R&D Systems,Cat:5868-AR)稀释到1μM，将45μL稀释后的样品与5μL 500mM CoCl2混合后60℃活化10min。50μL活化后的样品，加450μL 500mM L-精氨酸(pH7.4)，混匀后37℃水解15min，取样20μL，加至2mL尿素氮试剂混合液中(南京建成生物工程研究所)，立刻置沸水中准确水浴15min，冰水冷却5min，之后520nm处测定OD值。根据标准曲线计算尿素氮含量。Kcat(s-1)是指每摩尔酶每秒催化底物分解生成产物的摩尔数，Kcat(s-1)＝尿素氮浓度(mmol/mL)/[反应时间(s)x样品浓度/稀释倍数/分子量(mmol/mL)]。酶的比活是指每毫克的蛋白质中所含的精氨酸酶的催化活力，比活＝1/MW*Kcat*60*1000。
实验结果如下表7所示，由于融合GS序列后每个样品分子量不同，因此单位质量(mg)内的IU(比活)有差异，然而通过Kcat值可以明显看出水解精氨酸的活性并不降低，反而相对于hArg1而言略微上升。
表7：GS–Arg1融合蛋白的精氨酸水解活性
融合蛋白代号 Kcat(s<sup>-1</sup>) 比活(IU/mg)
GS100R9-hArg1 177.9 240.0
GS100R35-hArg1 177.5 243.8
GS100R52-hArg1 174.3 239.4
GS100R9-hArg1-GS100R9 167.4 185.2
GS100R35-hArg1-GS100R35 169.4 192.9
GS100R52-hArg1-GS100R52 167.5 190.7
GS100R74-hArg1-GS100R74 165.4 187.8
GS100R77-hArg1-GS100R77 164.2 187.0
GS100R98-hArg1-GS100R98 160.9 183.2
GS100R112-hArg1-GS100R112 169.3 192.8
GS200R9-hArg1 158.6 176.3
GS200R9-hArg1-GS200R9 161.1 132.0
GS400R9-hArg1-GS400R9 163.9 88.4
GS400R77-hArg1-GS400R77 160.6 90.2
GS500R9-hArg1 160.5 90.2
GLK<sub>RD</sub>-hArg1 154.6 112.5
rGLK116<sub>4</sub>-hArg1 165.5 132.1
GEE151-hArg1 170.0 202.3
hArg1 147.8 256.2
PBS / /
实施例9：GS与hArg1融合蛋白的免疫原性试验
SD大鼠随机均分组，每组10只，分别用表7中的蛋白免疫，3mg/kg，皮下注射，每周注射一次，连续注射4周，同时一组注射PBS作为阴性对照。给药前取血，最后一次免疫后两周，处死大鼠，取血，分离获得血清。用ELISA实验检测血清中GS抗体生成情况。具体地，GS-GCSF融合蛋白包被ELISA板(100ng/孔)，免疫动物血清稀释分别稀释100倍及500倍，与之在37℃孵育2h，最后用HRP标记的羊抗大鼠二抗(EarthOX,E030140-01)检测，读取OD450值。结果如下表8所示。GS-hArg1融合蛋白在用GS-hArg1融合蛋白包被时呈阳性，当用与hArg1无关蛋白包被(GS-GCSF融合蛋白)时则呈阴性，说明是hArg1在大鼠体内产生了较强的免疫原性而GS载体蛋白没有。而rGLK1164-hArg1则始终呈阳性，说明rGLK1164在大鼠体内产生了较强的免疫原性。
表8：GS与hArg1融合蛋白的免疫原性结果
Figure BDA0001827374440000341
+：OD450值为给药前样品的2倍以上，为阳性；
－：OD450值为给药前样品的2倍以下，为阴性。
实施例10：不同GS-hArg1类似蛋白的药代检测试验
SD大鼠随机均分组，每组7只，分别皮下注射表7中融合蛋白，2mg/kg，GS-hArg1融合蛋白给药组在注射前和注射后3h,8h,12h,24h,36h,48h,72h,96h,120h,144h,168h取血，分离获得血清。hArg1蛋白(R&D Systems,Cat:5868-AR)给药组在注射前及注射后3h,8h取血。
用夹心ELISA方法检测融合蛋白在大鼠体内的药代情况。100ng/孔的hArg1兔多抗(自制)包被过夜，PBST洗涤3次。5％脱脂奶粉封闭后，PBST洗涤3次，各时间点的血清稀释至指定的倍数，按100μl/孔加入到ELISA酶标板中，在37℃孵育2h后，PBST洗涤3次，加入生物素标记的hArg1兔多抗(自制)，37℃孵育2小时，PBST洗涤3次，最后HRP标记的链霉亲和素稀释5万倍后加入到ELISA板中，37℃孵育1小时后用常规TMB法检测，读取OD450值。结果如图3所示。表3中所示的类明胶蛋白(GS)的GRAVY值介于-1.0到0之间，而GLK1164则为-1.815，有着较大差异。另外，GEE151-hArg1(SEQ ID NO:245)中的GEE151由甘氨酸G及谷氨酸E组成，具有极低的GRAVY值(-2.467)，然而其对于药代的效果并不理想，甚至还远不如rGLK1164，而且制备极其困难。同样，GLKRD-hArg1(SEQ ID NO:241)中的GLKRD(GRAVY值为-0.785)由于不具备Gly-X-Y的结构，也没有起到与GS蛋白同样程度的效果。
实施例11：糖基化检测
蛋白样品通过高碘酸希夫碱(PAS)试剂法检测糖基含量：首先样品上样于10％SDS-PAGE，电泳结束后，采用Thermo Scientific糖蛋白染色试剂盒(货号24562，LotPE201610B)进行糖基染色：将电泳后的丙烯酰胺凝胶完全浸入在100ml50％甲醇中30分钟以固定凝胶；再用100ml 3％乙酸，轻轻摇晃10分钟清洗凝胶；转移凝胶至25ml氧化溶液，轻轻摇晃15分钟后，通过用100ml 3％乙酸轻轻摇晃5分钟洗凝胶。重复此步骤两次。转移凝胶至25ml糖蛋白染色试剂(Thermo Scientific，货号24562，Lot PE201610B)，并轻轻摇晃15分钟。
转移凝胶至25ml还原性溶液，轻轻摇晃5分钟。用3％乙酸轻轻摇晃5分钟洗涤凝胶，然后用超纯水清洗。糖蛋白出现紫红色条带后，于3％乙酸中保存凝胶。
结果如图4所示。经过染色，只有阳性对照蛋白和rGLK1164-hArg1被染色，而且rGLK1164-hArg1条带呈弥散状，表明此样品含有各种不同修饰导致的分子量大小有异的目的蛋白，因此极不均一。
实施例12：GS与hGH融合蛋白的制备
人生长激素(hGH，SEQ ID NO:5)具有显著的聚集倾向，当单独进行重组表达时，往往会产生大量无法逆转的聚体。将实施例2中经拼接后的GS片段与hGH基因融合表达(如表9所示)，N端与6His相连。核苷酸片段亚克隆至质粒pPIC9(Life Technologies)，构建成表达载体，以甲醇酵母Pichia pastor GS115(His-)为表达宿主菌，通过电转化将线性化的表达质粒转化到GS115中。30℃培养3天，至单菌落出现。甲醇诱导过程如实施例2所示。发酵液离心取上清后，加5x加样缓冲液混匀，100℃加热8-10min。经SDS-PAGE电泳筛选表达菌株。作为经典的理论指南，具体的细节步骤可参见Life Technologies公司的产品手册《PichiaExpression Kit，For Expression of Recombinant Proteins in Pichiapastoris，Catalog no.K1710-01》。
表9：GS与hGH融合蛋白
Figure BDA0001827374440000361
发酵液上清加入硫酸铵至电导180mS/cm，8000rpm，15min，10℃离心收集蛋白沉淀。沉淀用20mM PB pH7溶液溶解，之后再用硫酸铵在180mS/cm的电导下沉淀。取沉淀用20mM NaAc pH5溶液溶解，并用水稀释至电导4mS/cm以下。用Super Q-650M(TOSOH)进行纯化(Buffer A：20mM NaAc,pH5；Buffer B:0.5M NaCl+20mM NaAc,pH5)，按20％B，70％B，100％B一次洗脱。取70％B洗脱样品，调pH＝6，并用硫酸铵调电导至140mS/cm。用Phenyl HP(博格隆(上海)生物技术有限公司)进行纯化，直接用50mM PB pH6洗脱。洗脱样品80℃水浴30min灭活蛋白酶。待样品温度恢复至室温后，调pH到4，并稀释溶液至电导4mS/cm以下。
最后用Diamond SP Mustang(博格隆(上海)生物技术有限公司)进行纯化(缓冲液A：20mM NaAc，pH4；缓冲液B1:20mM NaAc，pH5；缓冲液B2:20mM PB，pH7)，用B1和B2先后洗脱，收集B2洗脱样品。
当样品纯度低于95％时，进行如下步骤：洗脱液上样到用平衡缓冲液(0.5M NaCl,20mM咪唑,20mM Tris-HCl,pH 7.5)平衡后的50ml Chelating Sepharose Fast Flow层析柱(GE Healthcare)，再平衡后用10％，50％，100％洗脱缓冲液(0.15M NaCl,0.5M咪唑,20mM Tris-HCl,pH 8.0)洗脱。
实施例13：GS-GH融合蛋白的热稳定性
用C18RP-HPLC定量实施例12制备得到的纯化后的GS-GH融合蛋白，调整浓度至约1.0mg/ml，分别置于室温及85℃下处理30分钟，离心去沉淀，取上清液进行SDS-PAGE。结果如图5所示。
实施例14：SEC-HPLC分析GS与hGH融合蛋白样品的聚集
将实施例12中经85℃加热处理的样品和分子量标准混合溶液，使用SEC-HPLC-UV分析。以相对分子量(Mr)为横坐标，实际测得的洗脱体积(Ve)为纵坐标，线性回归：Ve＝K1-K2logMr。K1与K2为常数，Mr为相对分子质量。检测方法如下：检测波长：280nm；色谱柱：柱温25℃，Sepax SRT-1000SEC 5μm(300×7.8mm)，流动相：50mM PB，150mM NaCl，pH7.2；运行时间：20分钟。当有明显聚体产生时，将会在SEC-HPLC图谱中出现高分子量的杂峰。结果如图6所示。hGH由于高温处理大量聚集沉淀，不进行液相分析。
实施例15：GS-GH样品的体外细胞活性检测
Ba/f3-GHR细胞用无IL-3的RPMI 1640培养基(含5％FBS和1mg/ml G418)饥饿处理4-6h后，转移至离心管中，1000RPM离心5min。用上述培养基重悬后计数，调整至2x 105/ml，铺96孔板，每孔100μL，即2万个细胞/孔。各待检蛋白用上述培养基稀释至合适的浓度，每孔加入10μL，刺激48h后，用MTT法检测，结果如下表10和图7所示。
表10
Figure BDA0001827374440000371
Figure BDA0001827374440000381
实施例16：不同GS-GH类似蛋白的药代检测试验
SD大鼠随机均分组，每组10只，分别皮下注射不同的GS-GH融合蛋白或hGH重组蛋白(Sino Biological,Cat:16122-H07E)，2mg/kg，注射前和注射后3h,8h,12h,24h,36h,48h,72h,96h,120h,144h,168h取血，分离获得血清。用夹心ELISA方法检测GS-GH蛋白在大鼠体内的药代情况。hGH抗体(Sino Biological,Cat:16122-R101)按100ng/孔加至ELISA酶标板，4℃包被过夜，PBST洗涤3次并5％奶粉封闭2小时，再次PBST洗涤3次，将各时间点的血清稀释至指定的倍数并加入到ELISA酶标板中，在37℃孵育2h后，PBST洗涤3次，加入生物素标记的hGH多克隆抗体(Sino Biological,Cat:16122-T24，生物素标记自制)，37℃孵育2h，PBST洗涤5次，最后HRP标记的链霉亲和素稀释5万倍后加入到ELISA板中，37℃孵育1h后常规TMB法检测，读取OD450值，结果如下表11所示。
表11
融合蛋白代号 半衰期(t<sub>1/2</sub>，小时) Cmax(μg/mL) AUC<sub>∞</sub>(μg/mL*h)
GS800R9-GH-GS100R9 17.2 2.4 77.9
GS800R35-GH-GS100R35 16.8 2.4 76.5
GS800R127-GH-GS100R127 16.3 2.3 76.3
GS800L91-GH-GS100L91 16.5 2.5 78.5
GS800L102-GH-GS100L102 17.5 2.5 79.0
GS800L146-GH-GS100L146 16.4 2.3 75.8
GS800S203-GH-GS100S203 16.7 2.2 74.9
hGH 0.14 1.8 0.54
实施例17：GS与GDF 15融合蛋白的制备
将实施例2中经拼接后的GS片段与GDF 15(SEQ ID NO:15)融合表达(如表12所示)，N端与6His相连。核苷酸片段亚克隆至质粒pPIC9(Life Technologies)，构建成表达载体，以甲醇酵母Pichia pastor GS115(His-)为表达宿主菌，通过电转化将线性化的表达质粒转化到GS115中。30℃培养3天，至单菌落出现。甲醇诱导过程如实施例2所示。发酵液离心取上清后，加5x加样缓冲液混匀，100℃加热8-10min。经SDS-PAGE电泳筛选表达菌株。作为经典的理论指南，具体的细节步骤可参见Life Technologies公司的产品手册《PichiaExpression Kit，For Expression of Recombinant Proteins in Pichiapastoris，Catalog no.K1710-01》。
表12
融合蛋白代号 氨基酸序列、核苷酸序列(SEQ ID NO:)
GS200R9-GDF15 277、278
GS200L23-GDF15 279、280
GS200L136-GDF15 281、282
GS200S14-GDF15 283、284
GS400R9-GDF15 285、286
GS400L23-GDF15 287、288
GS400L136-GDF15 289、290
GS400S14-GDF15 291、292
GS600R9-GDF15 293、294
GS600L23-GDF15 295、296
GS600L136-GDF15 297、298
GS600S14-GDF15 299、300
发酵液离心上清先用40％硫酸铵沉淀，用去离子水复溶后，上样到用平衡缓冲液(0.5M NaCl,20mM咪唑,20mM Tris-HCl,pH 7.5)平衡后的50ml Chelating SepharoseFast Flow层析柱(GE Healthcare)，再平衡后用0-100％洗脱缓冲液(0.15M NaCl,0.5M咪唑,20mM Tris-HCl,pH 8.0)线性洗脱。洗脱液加入35-50％饱和度的AS沉淀，8000rpm离心20min收集沉淀，用去离子水复溶。
GS与GDF15融合蛋白的SDS-PAGE电泳图如图8所示。
实施例18：GS与GDF15融合蛋白在DIO小鼠中的药效研究
7周龄雄性C57BL/6J雄性小鼠给予高脂饲料(60％kcal from fat)继续饲养16周(共23周)，到体重约为55g时进行试验。饲养条件：12h光照/12h黑暗，自由采食，单笼饲养，给药前一天根据体重和体重生长曲线对小鼠进行分组(8只/组)，第二天皮下给药处理。按照30nmol/千克体重的剂量给药，对照组注射等体积生理盐水(PBS)；融合蛋白4天一次，连续给药28天，每天测量小鼠体重及进食量。最后一次给药后的第5天处死。眼眶取血，将血浆标本储存在-80℃。计算每组动物给药前及处死时的平均体重变化和进食变化。结果如图9和10所示。
实施例19：GS与GLP-2类似物融合蛋白的制备
将实施例2中经拼接后的GS片段与胰高血糖素样肽2类似物GLP-2G(SEQ ID NO:1)融合(如表13所示)，C端与6His标签相连，核苷酸片段亚克隆至质粒pPIC9(LifeTechnologies)，构建成表达载体，以甲醇酵母Pichia pastor GS115(His-)为表达宿主菌，通过电转化将线性化的表达质粒转化到GS115中。30℃培养3天，至单菌落出现。将上述转化的重组酵母单菌落接种至10ml BMGY液体培养基中，30℃，250rpm培养24小时后，静置过夜，弃上清，加入10ml含1％甲醇的BMMY液体培养基，30℃，250rpm诱导表达。培养液离心取上清后加5*加样缓冲液混匀，100℃加热8-10min。经SDS-PAGE电泳筛选表达菌株。
表13
融合蛋白代号 氨基酸序列、核苷酸序列(SEQ ID NO:)
GLP2G-GS800R9 301、302
GLP2G-GS800S14 303、304
GLP2G-GS800S203 305、306
发酵液离心上清先用40％硫酸铵沉淀，用去离子水复溶后，上样到用平衡缓冲液(0.5M NaCl,20mM咪唑,20mM Tris-HCl,pH 7.5)平衡后的50ml Chelating SepharoseFast Flow层析柱(GE Healthcare)，再平衡后用10％，50％，100％洗脱缓冲液(0.15MNaCl,0.5M咪唑,20mM Tris-HCl,pH 8.0)洗脱。洗脱液混合后，加入30-50％饱和度的硫酸铵沉淀，8000rpm离心20min收集沉淀，用去离子水复溶。
实施例20：GS与GLP-2G融合蛋白的活性测定
GLP-2G融合蛋白体外细胞学活性检测采用荧光素酶报告基因检测法。将GLP-2R基因克隆至哺乳动物细胞表达质粒pCDNA3.1中，构建成重组表达质粒pCDNA3.1-GLP-2R，同时荧光素酶(luciferase)全长基因克隆至pCRE-EGFP(本实验保存)质粒上，替换EGFP基因，得到pCRE-Luc重组质粒。pCDNA3.1-GLP-2R和pCRE-Luc质粒按摩尔比1:10的比例转染CHO细胞，筛选稳转表达株，获得重组GLP-2R/Luc-CHO稳转细胞株。
在10-cm细胞培养皿中用含10％FBS和300μg/ml G418的DMEM/F12培养基培养细胞，等汇合度至90％左右时，弃去培养上清，加入2ml胰酶消化2min后，加入2ml含10％FBS和300μg/ml G418的DMEM/F12培养基中和，转移至15ml离心管中，800rpm离心5min后，弃去上清，加入2ml含10％FBS和300μg/ml G418的DMEM/F12培养基重悬，计数。用含10％FBS的DMEM/F12培养基稀释细胞至3x 105/ml，96孔板中每孔铺100μL，即每孔3万细胞，贴壁后换成含0.1％FBS的DMEM/F12培养基培养过夜。
铺在96孔板的细胞弃去上清后，将纯化的重组蛋白或GLP-2(杭州中肽生化有限公司，货号GLUC-002A)用含0.1％FBS的DMEM/F12培养基稀释至一系列指定浓度，加入到细胞培养孔中，100μL/孔，刺激6h后检测。根据lucifersae reporter kit(Ray Biotech,Cat:68-LuciR-S200)说明书进行检测。结果如表14及图11所示。
表14
融合蛋白代号 EC<sub>50</sub>(nM)
GLP2G-GS800R9 269.9
GLP2G-GS800S14 293.2
GLP2G-GS800S203 315.6
GLP-2 4.7
实施例21：GS与GLP2G融合蛋白的药代检测试验
SD大鼠随机均分组，每组10只，分别注射不同的融合蛋白，2mg/kg，皮下注射，注射前和注射后3h，8h，12h，24h，36h，48h，72h，96h，120h，144h，168h取血，分离获得血清。用夹心ELISA法检测融合蛋白在大鼠体内的药代情况。GLP-2抗体(Abcam,货号ab14183)按100ng/孔加至ELISA酶标板，4℃包被过夜，PBST洗涤3次并5％奶粉封闭2小时，再次PBST洗涤3次，将各时间点的血清稀释至指定的倍数并加入到ELISA酶标板中，在37℃孵育2h后，PBST洗涤3次，加入生物素标记的GLP-2多抗(Abcam,货号ab48292)，37℃孵育2h，PBST洗涤5次，最后HRP标记的链霉亲和素稀释5万倍后加入到ELISA板中，37℃孵育1h后常规TMB法检测，读取OD450值，结果如表15所示。
表15
融合蛋白代号 半衰期(t<sub>1/2</sub>，小时) Cmax(μg/mL) AUC<sub>∞</sub>(μg/mL*h)
GLP2G-GS800R9 41.5 7.1 550.2
GLP2G-GS800S14 42.8 7.0 545.7
GLP2G-GS800S203 45.2 7.3 589.4
实施例22：GS与ARVEGF融合蛋白的制备
将实施例2中经拼接后的GS片段与结合VEGF的锚定重复蛋白(Ankyrin repeatproteins，SEQ ID NO:3)融合(如表16所示)，C端与6His标签相连，核苷酸片段亚克隆至质粒pPIC9(Life Technologies)，构建成表达载体，以甲醇酵母Pichia pastor GS115(His-)为表达宿主菌，通过电转化将线性化的表达质粒转化到GS115中。30℃培养3天，至单菌落出现。将上述转化的重组酵母单菌落接种至10ml BMGY液体培养基中，30℃，250rpm培养24小时后，静置过夜，弃上清，加入10ml含1％甲醇的BMMY液体培养基，30℃，250rpm诱导表达。培养液上清加5倍加样缓冲液混匀，100℃加热8-10min。经SDS-PAGE电泳筛选表达菌株。发酵液先用80℃加热处理20分钟，离心沉淀杂蛋白后，上清用40％硫酸铵沉淀，用去离子水复溶并上样到用平衡缓冲液(0.5M NaCl,20mM咪唑,20mM Tris-HCl,pH 7.5)平衡后的50mlChelating Sepharose Fast Flow层析柱(GE Healthcare)，再平衡后用0-100％洗脱缓冲液(0.15M NaCl,0.5M咪唑,20mM Tris-HCl,pH 8.0)线性洗脱。洗脱液加入35-50％饱和度的AS沉淀，8000rpm离心20min收集沉淀，用去离子水复溶。
表16
融合蛋白代号 氨基酸序列、核苷酸序列(SEQ ID NO:)
GS600R9-AR<sub>VEGF</sub> 307、308
GS900R9-AR<sub>VEGF</sub> 309、310
实施例23：GS与ARVEGF融合蛋白的亲和力测定
采用BLI(Bio-layer inteferometry，ForteBio)对融合蛋白的结合亲和力进行测定。首先，将生物素Biotin(Thermo，Prod#21338，Sulfo-NHS)和VEGF按摩尔比2:1混合，进行标记，通过透析除去未参与标记的生物素；然后，根据Octet-QK的使用说明，选择高灵敏度实验程序，在亲和素探针SA(forteBIO，Part#18-5019)上加载生物素标记的VEGF；实验中所用的缓冲液是PBS(含0.1％Tween-20)，将梯度稀释的融合蛋白和对照抗体，根据程序的设置，加入96孔黑色板(Greiner，655209)的预定位置中。根据程序设置，结合融合蛋白，然后在PBST溶液中解离，获得实验曲线；采用Octet-QK的结果分析软件，实验结果用local full拟合曲线，计算kon、kdis、Kd。
表17概括了融合蛋白与对照药物Bevacizumab的Kd，从表中可以看出融合GS前后，ARVEGF对VEGF的平均亲和力无明显差异，与Bevacizumab(Medchemexpress，Cat.No.:HY-P9906)相比在同一个数量级。
表17：GS与ARVEGF融合蛋白的解离平衡常数(Kd)
Figure BDA0001827374440000431
实施例24：GS与ARVEGF融合蛋白的体外活性研究
用VEGF受体竞争抑制法测定ARVEGF的活性。ELISA板中加入5μg/mL的VEGF受体2/KDR(Abcam，ab155628)，每孔50μL，在37℃中放置2h。用1％BSA/TBS封闭，37℃放置2h。将ARVEGF和对照品Bevacizumab分别用PBST作3倍梯度稀释，将稀释好的样品80μL与等体积的1μg/mL的VEGF混合，37℃放置1h。将包被KDR的ELISA板洗板两次，拍干后，将梯度稀释后的混合物样品依次转移至该ELISA板中，37℃放置1h，然后洗板5次。向ELISA板中各孔加入1：1000稀释的鼠抗人VEGF单克隆抗体(sigma，V4758-.5mg)，每孔50μL，37℃放置1h，然后洗板5次。再加入1：1000稀释的HRP标记的羊抗鼠二抗(Pierce，31432，QA1969921)，每孔50μL，37℃放置1h，然后洗板6次。反应完后加入显色液，37℃避光显色15min，加入终止液终止显色反应，在酶标仪上读取OD450的数值，结果如表18和图12所示。
表18：GS与ARVEGF融合蛋白的IC50
蛋白样品 IC50(nM)
GS600R9-AR<sub>VEGF</sub> 0.59
GS900R9-AR<sub>VEGF</sub> 0.59
AR<sub>VEGF</sub> 0.64
Bevacizumab 0.55
实施例25：血清稳定性
GS-GH融合蛋白样品用40mM PB，pH7.4配制成2.0-3.0mg/ml，除菌过滤(0.22μm，Millipore)后，用大鼠血清稀释10倍，混匀，分装到无菌离心管中；置37℃培养箱，取0天、及第7天样品进行Western-blot分析，采用HRP标记的Anti-6X His
Figure BDA0001827374440000432
抗体(Abcam,ab1187)作为检测抗体。结果如图13所示。
实施例26：耐酶稳定性
称取适量胰蛋白酶(生工生物工程上海(股份)有限公司，货号A620627-0250)，用经高温灭菌的20mM PB(含0.15M NaCl，pH7.5)缓冲液溶解为质量浓度10％的溶液。将GS-GH融合蛋白(5mg/ml)和hGH(Sino Biological,Cat:16122-H07E,配制成1mg/ml)，分别加入质量终浓度0、0.02％、0.1％、0.5％的胰酶溶液混匀，用20mM PB(含0.15M NaCl，pH7.5)补齐体积。然后放37℃孵育40min；取出后加入电泳缓冲液并煮沸10min终止反应。hGH样品的0、0.02％、0.1％、0.5％胰酶处理组分别上样于12％SDS-PAGE，GS-GH融合蛋白取0％及0.5％胰酶处理组分别上样于8％SDS-PAGE。如图14所示，hGH在0.02％胰酶处理下已经几乎无完整蛋白，而GS-GH融合蛋白则几乎没有任何降解。
上述实施例仅例示性说明本发明的原理及其功效，而非用于限制本发明。任何熟悉此技术的人士皆可在不违背本发明的精神及范畴下，对上述实施例进行修饰或改变。因此，举凡所属技术领域中具有通常知识者在未脱离本发明所揭示的精神与技术思想下所完成的一切等效修饰或改变，仍应由本发明的权利要求所涵盖。
序列表
<110> 浙江道尔生物科技有限公司
<120> 一种改善生物活性蛋白性质的载体蛋白
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130
<210> 5
<211> 191
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 5
Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg
1 5 10 15
Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu
20 25 30
Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro
35 40 45
Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg
50 55 60
Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu
65 70 75 80
Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val
85 90 95
Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp
100 105 110
Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu
115 120 125
Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser
130 135 140
Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr
145 150 155 160
Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe
165 170 175
Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe
180 185 190
<210> 6
<211> 114
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 6
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile
1 5 10 15
Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His
20 25 30
Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln
35 40 45
Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu
50 55 60
Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val
65 70 75 80
Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile
85 90 95
Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn
100 105 110
Thr Ser
<210> 7
<211> 321
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 7
Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser Lys
1 5 10 15
Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg Lys
20 25 30
Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys Asp
35 40 45
Tyr Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe Gln
50 55 60
Ile Val Lys Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu Ala
65 70 75 80
Gly Lys Val Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val Leu
85 90 95
Gly Gly Asp His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala Arg
100 105 110
Val His Pro Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp Ile
115 120 125
Asn Thr Pro Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro Val
130 135 140
Ser Phe Leu Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro Gly
145 150 155 160
Phe Ser Trp Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr Ile
165 170 175
Gly Leu Arg Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr Leu
180 185 190
Gly Ile Lys Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly
195 200 205
Lys Val Met Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg
210 215 220
Pro Ile His Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr
225 230 235 240
Pro Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly
245 250 255
Leu Tyr Ile Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu
260 265 270
Asp Ile Met Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val
275 280 285
Thr Arg Thr Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly
290 295 300
Leu Ala Arg Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro
305 310 315 320
Lys
<210> 8
<211> 216
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 8
Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu
1 5 10 15
Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro
20 25 30
His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr
35 40 45
Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala
50 55 60
Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu
65 70 75 80
Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His
85 90 95
Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu
100 105 110
Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro
115 120 125
Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser
130 135 140
Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu
145 150 155 160
Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro
165 170 175
Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu
180 185 190
Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala
195 200 205
Val Arg Ser Pro Ser Phe Glu Lys
210 215
<210> 9
<211> 174
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 9
Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys
1 5 10 15
Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln
20 25 30
Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val
35 40 45
Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys
50 55 60
Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser
65 70 75 80
Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser
85 90 95
Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp
100 105 110
Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro
115 120 125
Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe
130 135 140
Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe
145 150 155 160
Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro
165 170
<210> 10
<211> 165
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 10
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu
1 5 10 15
Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His
20 25 30
Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe
35 40 45
Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp
50 55 60
Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu
65 70 75 80
Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp
85 90 95
Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu
100 105 110
Gly Ala Gln Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro
115 120 125
Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr
130 135 140
Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys
145 150 155 160
Arg Thr Gly Asp Arg
165
<210> 11
<211> 39
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 11
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu
1 5 10 15
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser
20 25 30
Ser Gly Ala Pro Pro Pro Ser
35
<210> 12
<211> 184
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 12
Pro Val Pro Pro Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg
1 5 10 15
Gln Pro Leu Thr Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile
20 25 30
Leu Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn
35 40 45
Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu
50 55 60
Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu
65 70 75 80
Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val
85 90 95
Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala
100 105 110
Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys
115 120 125
Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn
130 135 140
Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp
145 150 155 160
Met Thr Thr His Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser
165 170 175
Ser Leu Arg Ala Leu Arg Gln Met
180
<210> 13
<211> 31
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 13
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu
1 5 10 15
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly
20 25 30
<210> 14
<211> 151
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 14
Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu Gln Ser
1 5 10 15
Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln Ile Thr
20 25 30
Phe Glu Phe Val Asp Gln Glu Glu Leu Lys Asp Pro Val Cys Tyr Leu
35 40 45
Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr Met Arg
50 55 60
Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu Gln Glu
65 70 75 80
Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu Glu His
85 90 95
Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln Leu Leu
100 105 110
Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu Asp Lys
115 120 125
Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala Glu Cys
130 135 140
Ser Ser Gln Asp Val Val Thr
145 150
<210> 15
<211> 112
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 15
Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg
1 5 10 15
Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp
20 25 30
Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys
35 40 45
Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser
50 55 60
Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro
65 70 75 80
Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val
85 90 95
Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile
100 105 110
<210> 16
<211> 181
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 16
His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val
1 5 10 15
Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His
20 25 30
Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser
35 40 45
Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln
50 55 60
Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly
65 70 75 80
Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg
85 90 95
Glu Arg Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His
100 105 110
Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro
115 120 125
Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro
130 135 140
Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val
145 150 155 160
Gly Ser Ser Asp Pro Leu Ser Met Val Gly Gly Ser Gln Gly Arg Ser
165 170 175
Pro Ser Tyr Glu Ser
180
<210> 17
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 17
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly
1 5 10 15
Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala
20 25
<210> 18
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 18
ggtgctccag gtgaaccagg tccagctggt ccaccaggtg ctgaaggtgc tccaggtcca 60
gctggtccag aaggtgaagc t 81
<210> 19
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 19
Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly
1 5 10 15
Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu
20 25
<210> 20
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 20
ggtgctgaag gtgaaccagg tgaagctggt ccaccaggtg ctccaggtga agctggtgct 60
gaaggtgctc caggtccaga a 81
<210> 21
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 21
Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly
1 5 10 15
Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro
20 25
<210> 22
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 22
ggtgaaccag gtgaagctgg tccagaaggt gctccaggtc cagctggtga accaggtgct 60
ccaggtgaag ctggtgaacc a 81
<210> 23
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 23
Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly
1 5 10 15
Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala
20 25
<210> 24
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 24
ggtccaccag gtccagctgg tgctccaggt ccagctggtg aaccaggtga agctggtcca 60
ccaggtgctc caggtccagc t 81
<210> 25
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 25
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro
20 25
<210> 26
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 26
ggtccaccag gtgaagctgg tgctccaggt ccagaaggtg ctgaaggtga agctggtgaa 60
ccaggtccag ctggtgaacc a 81
<210> 27
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 27
Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly
1 5 10 15
Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
20 25
<210> 28
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 28
ggtccagaag gtgctccagg tccaccaggt ccagctggtg aaccaggtcc agctggtgct 60
ccaggtccac caggtgaagc t 81
<210> 29
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 29
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
1 5 10 15
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro
20 25
<210> 30
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 30
ggtccagctg gtgctccagg tgaagctggt ccaccaggtc cagctggtgc tgaaggtgaa 60
gctggtccag ctggtgctcc a 81
<210> 31
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 31
Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly
1 5 10 15
Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro
20 25
<210> 32
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 32
ggtgaaccag gtccagaagg tccaccaggt gaagctggtg ctccaggtcc accaggtgct 60
ccaggtgctg aaggtgaacc a 81
<210> 33
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 33
Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly
1 5 10 15
Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro
20 25
<210> 34
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 34
ggtgctccag gtccagaagg tgctgaaggt gaagctggtg aaccaggtcc agctggtgaa 60
ccaggtccag aaggtgctcc a 81
<210> 35
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 35
Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly
1 5 10 15
Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro
20 25
<210> 36
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 36
ggtccaccag gtccagctgg tgaaccaggt ccagctggtg ctccaggtcc accaggtgaa 60
gctggtccag ctggtgctcc a 81
<210> 37
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 37
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
1 5 10 15
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu
20 25
<210> 38
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 38
ggtgaagctg gtccaccagg tccagctggt gctgaaggtg aagctggtcc agctggtgct 60
ccaggtgaac caggtccaga a 81
<210> 39
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 39
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly
1 5 10 15
Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro
20 25
<210> 40
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 40
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 60
ccaggtgctc caggtgaacc a 81
<210> 41
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 41
Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly
1 5 10 15
Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro
20 25
<210> 42
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 42
ggtccagaag gtgctgaagg tgaagctggt gaaccaggtc cagctggtga accaggtcca 60
gaaggtgctc caggtccacc a 81
<210> 43
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 43
Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly
1 5 10 15
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala
20 25
<210> 44
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 44
ggtccagctg gtgaaccagg tccagctggt gctccaggtc caccaggtga agctggtcca 60
gctggtgctc caggtgaagc t 81
<210> 45
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 45
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
1 5 10 15
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro
20 25
<210> 46
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 46
ggtccaccag gtccagctgg tgctgaaggt gaagctggtc cagctggtgc tccaggtgaa 60
ccaggtccag aaggtccacc a 81
<210> 47
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 47
Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly
1 5 10 15
Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala
20 25
<210> 48
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 48
ggtgaagctg gtgctccagg tccaccaggt gctccaggtg ctgaaggtga accaggtgct 60
ccaggtgaac caggtccagc t 81
<210> 49
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 49
Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Glu Glu Gly Pro Glu Gly
1 5 10 15
Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro
20 25
<210> 50
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 50
ggtgaaccag gtccagaagg tgctgctggt gaagaaggtc cagaaggtgc tgaaggtcca 60
gctggtccag ctggtgctcc a 81
<210> 51
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 51
Gly Ala Pro Gly Ala Glu Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly
1 5 10 15
Glu Pro Gly Ala Pro Gly Pro Glu Gly Ala Ala
20 25
<210> 52
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 52
ggtgctccag gtgctgaagg tgaagaaggt ccaccaggtg aagctggtga accaggtgct 60
ccaggtccag aaggtgctgc t 81
<210> 53
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 53
Gly Pro Pro Gly Ala Glu Gly Glu Ala Gly Glu Ala Gly Glu Ala Gly
1 5 10 15
Pro Ala Gly Glu Glu Gly Pro Pro Gly Ala Pro
20 25
<210> 54
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 54
ggtccaccag gtgctgaagg tgaagctggt gaagctggtg aagctggtcc agctggtgaa 60
gaaggtccac caggtgctcc a 81
<210> 55
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 55
Gly Pro Pro Gly Glu Ala Gly Glu Glu Gly Ala Pro Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Pro Pro Gly Ala Glu Gly Pro Ala
20 25
<210> 56
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 56
ggtccaccag gtgaagctgg tgaagaaggt gctccaggtg ctgaaggtga agctggtcca 60
ccaggtgctg aaggtccagc t 81
<210> 57
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 57
Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Glu Ala Gly Ala Pro Gly
1 5 10 15
Pro Glu Gly Ala Ala Gly Glu Pro Gly Pro Glu
20 25
<210> 58
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 58
ggtgaagctg gtccaccagg tgaagctggt gaagctggtg ctccaggtcc agaaggtgct 60
gctggtgaac caggtccaga a 81
<210> 59
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 59
Gly Glu Glu Gly Glu Ala Gly Ala Pro Gly Glu Glu Gly Pro Pro Gly
1 5 10 15
Glu Ala Gly Pro Ala Gly Pro Pro Gly Ala Ala
20 25
<210> 60
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 60
ggtgaagaag gtgaagctgg tgctccaggt gaagaaggtc caccaggtga agctggtcca 60
gctggtccac caggtgctgc t 81
<210> 61
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 61
Gly Pro Ala Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Glu Pro Gly
1 5 10 15
Pro Ala Gly Ala Glu Gly Pro Pro Gly Ala Ala
20 25
<210> 62
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 62
ggtccagctg gtgctgaagg tgaagaaggt gaaccaggtg aaccaggtcc agctggtgct 60
gaaggtccac caggtgctgc t 81
<210> 63
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 63
Gly Pro Ala Gly Pro Glu Gly Pro Glu Gly Ala Ala Gly Ala Glu Gly
1 5 10 15
Glu Glu Gly Glu Ala Gly Pro Pro Gly Pro Ala
20 25
<210> 64
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 64
ggtccagctg gtccagaagg tccagaaggt gctgctggtg ctgaaggtga agaaggtgaa 60
gctggtccac caggtccagc t 81
<210> 65
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 65
Gly Ala Glu Gly Pro Ala Gly Pro Glu Gly Ala Pro Gly Ala Glu Gly
1 5 10 15
Glu Glu Gly Pro Pro Gly Ala Glu Gly Ala Pro
20 25
<210> 66
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 66
ggtgctgaag gtccagctgg tccagaaggt gctccaggtg ctgaaggtga agaaggtcca 60
ccaggtgctg aaggtgctcc a 81
<210> 67
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 67
Gly Pro Ala Gly Glu Glu Gly Pro Glu Gly Ala Pro Gly Ala Ala Gly
1 5 10 15
Pro Pro Gly Ala Pro Gly Glu Glu Gly Glu Ala
20 25
<210> 68
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 68
ggtccagctg gtgaagaagg tccagaaggt gctccaggtg ctgctggtcc accaggtgct 60
ccaggtgaag aaggtgaagc t 81
<210> 69
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 69
Gly Ala Glu Gly Ala Glu Gly Ala Glu Gly Glu Pro Gly Pro Ala Gly
1 5 10 15
Pro Ala Gly Pro Pro Gly Glu Glu Gly Pro Ala
20 25
<210> 70
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 70
ggtgctgaag gtgctgaagg tgctgaaggt gaaccaggtc cagctggtcc agctggtcca 60
ccaggtgaag aaggtccagc t 81
<210> 71
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 71
Gly Glu Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Pro Gly
1 5 10 15
Ala Pro Gly Ala Glu Gly Glu Glu Gly Ala Ala
20 25
<210> 72
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 72
ggtgaaccag gtgctccagg tgctgaaggt gaaccaggtc caccaggtgc tccaggtgct 60
gaaggtgaag aaggtgctgc t 81
<210> 73
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 73
Gly Ala Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly
1 5 10 15
Pro Pro Gly Glu Glu Gly Ala Ala Gly Ala Glu
20 25
<210> 74
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 74
ggtgctgaag gtccaccagg tccagaaggt gctgaaggtc cagctggtcc accaggtgaa 60
gaaggtgctg ctggtgctga a 81
<210> 75
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 75
Gly Glu Glu Gly Glu Pro Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly
1 5 10 15
Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Pro
20 25
<210> 76
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 76
ggtgaagaag gtgaaccagg tgctgaaggt ccagctggtc cagctggtga agctggtgct 60
gaaggtgctc caggtccacc a 81
<210> 77
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 77
Gly Glu Ala Gly Ala Pro Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly
1 5 10 15
Glu Glu Gly Pro Glu Gly Ala Pro Gly Ala Glu
20 25
<210> 78
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 78
ggtgaagctg gtgctccagg tgaagctggt ccagctggtc caccaggtga agaaggtcca 60
gaaggtgctc caggtgctga a 81
<210> 79
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 79
Gly Pro Pro Gly Ala Ala Gly Glu Glu Gly Pro Ala Gly Ala Pro Gly
1 5 10 15
Glu Pro Gly Ala Ala Gly Glu Glu Gly Pro Glu
20 25
<210> 80
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 80
ggtccaccag gtgctgctgg tgaagaaggt ccagctggtg ctccaggtga accaggtgct 60
gctggtgaag aaggtccaga a 81
<210> 81
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 81
Gly Ala Pro Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly Pro Glu Gly
1 5 10 15
Glu Pro Gly Ala Ala Gly Ala Glu Gly Ala Glu
20 25
<210> 82
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 82
ggtgctccag gtgaaccagg tgctccaggt ccagaaggtc cagaaggtga accaggtgct 60
gctggtgctg aaggtgctga a 81
<210> 83
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 83
Gly Ala Glu Gly Ala Ala Gly Glu Glu Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Ala Pro Gly Ala Pro Gly Pro Pro Gly Glu Pro
20 25
<210> 84
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 84
ggtgctgaag gtgctgctgg tgaagaaggt ccagaaggtg ctgaaggtgc tccaggtgct 60
ccaggtccac caggtgaacc a 81
<210> 85
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 85
Gly Ala Pro Gly Ala Ala Gly Glu Ala Gly Pro Pro Gly Pro Glu Gly
1 5 10 15
Glu Ala Gly Glu Ala Gly Glu Glu Gly Pro Pro
20 25
<210> 86
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 86
ggtgctccag gtgctgctgg tgaagctggt ccaccaggtc cagaaggtga agctggtgaa 60
gctggtgaag aaggtccacc a 81
<210> 87
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 87
Gly Ala Pro Gly Glu Pro Gly Glu Glu Gly Glu Pro Gly Ala Ala Gly
1 5 10 15
Pro Pro Gly Ala Glu Gly Ala Glu Gly Pro Ala
20 25
<210> 88
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 88
ggtgctccag gtgaaccagg tgaagaaggt gaaccaggtg ctgctggtcc accaggtgct 60
gaaggtgctg aaggtccagc t 81
<210> 89
<211> 27
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 89
Gly Glu Pro Gly Pro Ala Gly Pro Glu Gly Glu Glu Gly Ala Ala Gly
1 5 10 15
Glu Ala Gly Pro Pro Gly Glu Ala Gly Ala Pro
20 25
<210> 90
<211> 81
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 90
ggtgaaccag gtccagctgg tccagaaggt gaagaaggtg ctgctggtga agctggtcca 60
ccaggtgaag ctggtgctcc a 81
<210> 91
<211> 117
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 91
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala
115
<210> 92
<211> 351
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 92
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc t 351
<210> 93
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 93
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala
20 25 30
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
35 40 45
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
100 105
<210> 94
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 94
ggtccaccag gtgaagctgg tgctccaggt ccagaaggtg ctgaaggtga agctggtgaa 60
ccaggtccag ctggtgaacc aggtccagct ggtgctccag gtgaagctgg tccaccaggt 120
ccagctggtg ctgaaggtga agctggtcca gctggtgctc caggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 300
gctccaggtc caccaggtga agct 324
<210> 95
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 95
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
1 5 10 15
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu
20 25 30
Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro
35 40 45
Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
100 105
<210> 96
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 96
ggtccagctg gtgctccagg tgaagctggt ccaccaggtc cagctggtgc tgaaggtgaa 60
gctggtccag ctggtgctcc aggtccacca ggtgaagctg gtgctccagg tccagaaggt 120
gctgaaggtg aagctggtga accaggtcca gctggtgaac caggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 300
gctccaggtc caccaggtga agct 324
<210> 97
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 97
Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly
1 5 10 15
Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Pro
20 25 30
Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
35 40 45
Gly Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly
50 55 60
Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu
65 70 75 80
Ala Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu
85 90 95
Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro
100 105
<210> 98
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 98
ggtccagaag gtgctccagg tccaccaggt ccagctggtg aaccaggtcc agctggtgct 60
ccaggtccac caggtgaagc tggtgaacca ggtccagaag gtccaccagg tgaagctggt 120
gctccaggtc caccaggtgc tccaggtgct gaaggtgaac caggtccaga aggtgctcca 180
ggtccaccag gtccagctgg tgaaccaggt ccagctggtg ctccaggtcc accaggtgaa 240
gctggtccac caggtgaagc tggtgctcca ggtccagaag gtgctgaagg tgaagctggt 300
gaaccaggtc cagctggtga acca 324
<210> 99
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 99
Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly
1 5 10 15
Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu
20 25 30
Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala
35 40 45
Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly
50 55 60
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro
65 70 75 80
Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu
85 90 95
Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala
100 105
<210> 100
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 100
ggtccagaag gtgctgaagg tgaagctggt gaaccaggtc cagctggtga accaggtcca 60
gaaggtgctc caggtccacc aggtccagct ggtgaaccag gtccagctgg tgctccaggt 120
ccaccaggtg aagctggtcc agctggtgct ccaggtgaag ctggtccacc aggtccagct 180
ggtgctgaag gtgaagctgg tccagctggt gctccaggtg aaccaggtcc agaaggtcca 240
ccaggtgaag ctggtgctcc aggtccacca ggtgctccag gtgctgaagg tgaaccaggt 300
gctccaggtg aaccaggtcc agct 324
<210> 101
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 101
Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly
1 5 10 15
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro
20 25 30
Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro
35 40 45
Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly
50 55 60
Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro
65 70 75 80
Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu
85 90 95
Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala
100 105
<210> 102
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 102
ggtccagctg gtgaaccagg tccagctggt gctccaggtc caccaggtga agctggtcca 60
gctggtgctc caggtgaagc tggtccacca ggtccagctg gtgctgaagg tgaagctggt 120
ccagctggtg ctccaggtga accaggtcca gaaggtccac caggtccaga aggtgctgaa 180
ggtgaagctg gtgaaccagg tccagctggt gaaccaggtc cagaaggtgc tccaggtcca 240
ccaggtgaag ctggtgctcc aggtccacca ggtgctccag gtgctgaagg tgaaccaggt 300
gctccaggtg aaccaggtcc agct 324
<210> 103
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 103
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
1 5 10 15
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala
20 25 30
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
35 40 45
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly
50 55 60
Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro
65 70 75 80
Ala Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro
85 90 95
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala
100 105
<210> 104
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 104
ggtccaccag gtccagctgg tgctgaaggt gaagctggtc cagctggtgc tccaggtgaa 60
ccaggtccag aaggtccacc aggtccagaa ggtgctgaag gtgaagctgg tgaaccaggt 120
ccagctggtg aaccaggtcc agaaggtgct ccaggtccac caggtgaagc tggtgctcca 180
ggtccaccag gtgctccagg tgctgaaggt gaaccaggtg ctccaggtga accaggtcca 240
gctggtccag ctggtgaacc aggtccagct ggtgctccag gtccaccagg tgaagctggt 300
ccagctggtg ctccaggtga agct 324
<210> 105
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 105
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
1 5 10 15
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
100 105
<210> 106
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 106
ggtccaccag gtccagctgg tgctgaaggt gaagctggtc cagctggtgc tccaggtgaa 60
ccaggtccag aaggtccacc aggtccagaa ggtgctccag gtccaccagg tccagctggt 120
gaaccaggtc cagctggtgc tccaggtcca ccaggtgaag ctggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 300
gctccaggtc caccaggtga agct 324
<210> 107
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 107
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly
1 5 10 15
Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu
20 25 30
Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu
35 40 45
Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly
50 55 60
Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu
65 70 75 80
Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala
100 105
<210> 108
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 108
ggtgctccag gtgaaccagg tccagctggt ccaccaggtg ctgaaggtgc tccaggtcca 60
gctggtccag aaggtgaagc tggtgctgaa ggtgaaccag gtgaagctgg tccaccaggt 120
gctccaggtg aagctggtgc tgaaggtgct ccaggtccag aaggtgaacc aggtgaagct 180
ggtccagaag gtgctccagg tccagctggt gaaccaggtg ctccaggtga agctggtgaa 240
ccaggtccac caggtccagc tggtgctcca ggtccagctg gtgaaccagg tgaagctggt 300
ccaccaggtg ctccaggtcc agct 324
<210> 109
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 109
Gly Ala Ala Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly
1 5 10 15
Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Ala Glu Gly Ala
20 25 30
Ala Gly Glu Ala Gly Ala Pro Gly Ala Glu Gly Glu Ala Gly Ala Glu
35 40 45
Gly Ala Pro Gly Pro Glu Gly Ala Pro Gly Ala Ala Gly Pro Ala Gly
50 55 60
Ala Ala Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu
65 70 75 80
Ala Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala
85 90 95
Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro
100 105
<210> 110
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 110
ggtgctgctg gtccagctgg tgctccaggt ccagctggtg aaccaggtga agctggtgct 60
gaaggtgctc caggtccagc tggtgctgaa ggtgctgctg gtgaagctgg tgctccaggt 120
gctgaaggtg aagctggtgc tgaaggtgct ccaggtccag aaggtgctcc aggtgctgct 180
ggtccagctg gtgctgctgg tgctgaaggt gctccaggtc cagctggtcc agaaggtgaa 240
gctggtgaac caggtgaagc tggtccagaa ggtgctccag gtccagctgg tgaaccaggt 300
gctccaggtg aagctggtga acca 324
<210> 111
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 111
Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly
1 5 10 15
Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
20 25 30
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
35 40 45
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
50 55 60
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
65 70 75 80
Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
85 90 95
Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro
100 105
<210> 112
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 112
ggtgctccag gtccagaagg tgctgaaggt gaagctggtg aaccaggtcc agctggtgaa 60
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 120
gctccaggtc caccaggtga agctggtcca gctggtgctc caggtgaagc tggtccacca 180
ggtccagctg gtgctgaagg tgaagctggt ccagctggtg ctccaggtga accaggtcca 240
gaaggtccac caggtgaagc tggtgctcca ggtccaccag gtgctccagg tgctgaaggt 300
gaaccaggtg ctccaggtga acca 324
<210> 113
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 113
Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Glu Glu Gly Pro Glu Gly
1 5 10 15
Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Ala
20 25 30
Glu Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Ala Pro
35 40 45
Gly Pro Glu Gly Ala Ala Gly Pro Pro Gly Ala Glu Gly Glu Ala Gly
50 55 60
Glu Ala Gly Glu Ala Gly Pro Ala Gly Glu Glu Gly Pro Pro Gly Ala
65 70 75 80
Pro Gly Pro Pro Gly Glu Ala Gly Glu Glu Gly Ala Pro Gly Ala Glu
85 90 95
Gly Glu Ala Gly Pro Pro Gly Ala Glu Gly Pro Ala
100 105
<210> 114
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 114
ggtgaaccag gtccagaagg tgctgctggt gaagaaggtc cagaaggtgc tgaaggtcca 60
gctggtccag ctggtgctcc aggtgctcca ggtgctgaag gtgaagaagg tccaccaggt 120
gaagctggtg aaccaggtgc tccaggtcca gaaggtgctg ctggtccacc aggtgctgaa 180
ggtgaagctg gtgaagctgg tgaagctggt ccagctggtg aagaaggtcc accaggtgct 240
ccaggtccac caggtgaagc tggtgaagaa ggtgctccag gtgctgaagg tgaagctggt 300
ccaccaggtg ctgaaggtcc agct 324
<210> 115
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 115
Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Glu Ala Gly Ala Pro Gly
1 5 10 15
Pro Glu Gly Ala Ala Gly Glu Pro Gly Pro Glu Gly Glu Glu Gly Glu
20 25 30
Ala Gly Ala Pro Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Pro Ala
35 40 45
Gly Pro Pro Gly Ala Ala Gly Pro Ala Gly Ala Glu Gly Glu Glu Gly
50 55 60
Glu Pro Gly Glu Pro Gly Pro Ala Gly Ala Glu Gly Pro Pro Gly Ala
65 70 75 80
Ala Gly Pro Ala Gly Pro Glu Gly Pro Glu Gly Ala Ala Gly Ala Glu
85 90 95
Gly Glu Glu Gly Glu Ala Gly Pro Pro Gly Pro Ala
100 105
<210> 116
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 116
ggtgaagctg gtccaccagg tgaagctggt gaagctggtg ctccaggtcc agaaggtgct 60
gctggtgaac caggtccaga aggtgaagaa ggtgaagctg gtgctccagg tgaagaaggt 120
ccaccaggtg aagctggtcc agctggtcca ccaggtgctg ctggtccagc tggtgctgaa 180
ggtgaagaag gtgaaccagg tgaaccaggt ccagctggtg ctgaaggtcc accaggtgct 240
gctggtccag ctggtccaga aggtccagaa ggtgctgctg gtgctgaagg tgaagaaggt 300
gaagctggtc caccaggtcc agct 324
<210> 117
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 117
Gly Ala Glu Gly Pro Ala Gly Pro Glu Gly Ala Ala Gly Ala Pro Gly
1 5 10 15
Ala Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Glu
20 25 30
Ala Gly Pro Glu Gly Ala Pro Gly Ala Ala Gly Pro Ala Gly Ala Pro
35 40 45
Gly Ala Glu Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly Ala Ala Gly
50 55 60
Glu Pro Gly Pro Ala Gly Pro Ala Gly Ala Ala Gly Pro Pro Gly Pro
65 70 75 80
Ala Gly Glu Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Ala
85 90 95
Gly Ala Pro Gly Ala Glu Gly Pro Pro Gly Ala Ala
100 105
<210> 118
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 118
ggtgctgaag gtccagctgg tccagaaggt gctgctggtg ctccaggtgc tgctggtcca 60
ccaggtgctg aaggtgctcc aggtccagct ggtgaagctg gtccagaagg tgctccaggt 120
gctgctggtc cagctggtgc tccaggtgct gaaggtgctg ctggtgctcc aggtgctgaa 180
ggtgctgctg gtgaaccagg tccagctggt ccagctggtg ctgctggtcc accaggtcca 240
gctggtgaac caggtgctcc aggtgctgaa ggtgaaccag gtgctgctgg tgctccaggt 300
gctgaaggtc caccaggtgc tgct 324
<210> 119
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 119
Gly Ala Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly
1 5 10 15
Pro Pro Gly Glu Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly Glu
20 25 30
Pro Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Glu Ala Gly Ala Glu
35 40 45
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Ala Gly Pro Pro Gly Glu Glu Gly Pro Glu Gly Ala Pro Gly Ala
65 70 75 80
Glu Gly Pro Pro Gly Ala Ala Gly Glu Glu Gly Pro Ala Gly Ala Pro
85 90 95
Gly Glu Pro Gly Ala Ala Gly Glu Glu Gly Pro Glu
100 105
<210> 120
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 120
ggtgctgaag gtccaccagg tccagaaggt gctgaaggtc cagctggtcc accaggtgaa 60
gaaggtgctg ctggtgctga aggtgaagaa ggtgaaccag gtgctgaagg tccagctggt 120
ccagctggtg aagctggtgc tgaaggtgct ccaggtccac caggtgaagc tggtgctcca 180
ggtgaagctg gtccagctgg tccaccaggt gaagaaggtc cagaaggtgc tccaggtgct 240
gaaggtccac caggtgctgc tggtgaagaa ggtccagctg gtgctccagg tgaaccaggt 300
gctgctggtg aagaaggtcc agaa 324
<210> 121
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 121
Gly Ala Pro Gly Ala Pro Gly Ala Ala Gly Pro Glu Gly Pro Glu Gly
1 5 10 15
Glu Pro Gly Ala Ala Gly Ala Glu Gly Ala Glu Gly Ala Glu Gly Ala
20 25 30
Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Ala Pro Gly Ala Pro
35 40 45
Gly Ala Pro Gly Ala Ala Gly Ala Pro Gly Ala Ala Gly Glu Ala Gly
50 55 60
Ala Pro Gly Pro Glu Gly Glu Ala Gly Glu Ala Gly Glu Glu Gly Ala
65 70 75 80
Pro Gly Ala Ala Gly Glu Pro Gly Glu Glu Gly Glu Pro Gly Ala Ala
85 90 95
Gly Ala Pro Gly Ala Ala Gly Ala Glu Gly Pro Ala
100 105
<210> 122
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 122
ggtgctccag gtgctccagg tgctgctggt ccagaaggtc cagaaggtga accaggtgct 60
gctggtgctg aaggtgctga aggtgctgaa ggtgctgctg gtgctccagg tccagaaggt 120
gctgaaggtg ctccaggtgc tccaggtgct ccaggtgctg ctggtgctcc aggtgctgct 180
ggtgaagctg gtgctccagg tccagaaggt gaagctggtg aagctggtga agaaggtgct 240
ccaggtgctg ctggtgaacc aggtgaagaa ggtgaaccag gtgctgctgg tgctccaggt 300
gctgctggtg ctgaaggtcc agct 324
<210> 123
<211> 117
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 123
Gly Pro Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly
1 5 10 15
Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala
20 25 30
Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala
35 40 45
Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly
50 55 60
Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu
65 70 75 80
Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala
85 90 95
Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly
100 105 110
Pro Pro Gly Pro Ala
115
<210> 124
<211> 351
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 124
ggtccacctg gtgctccagg tgaaccaggt ccagctggtc caccaggtgc tgaaggtgct 60
ccaggtccag ctggtccaga aggtgaagct ggtgctgaag gtgaaccagg tgaagctggt 120
ccaccaggtg ctccaggtga agctggtgct gaaggtgctc caggtccaga aggtgaacca 180
ggtgaagctg gtccagaagg tgctccaggt ccagctggtg aaccaggtgc tccaggtgaa 240
gctggtgaac caggtccacc aggtccagct ggtgctccag gtccagctgg tgaaccaggt 300
gaagctggtc caccaggtgc tccaggtcca gctggtccac caggtccagc t 351
<210> 125
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 125
Gly Pro Pro Gly Ala Ala Gly Ala Glu Gly Pro Ala Gly Ala Pro Gly
1 5 10 15
Ala Ala Gly Ala Ala Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Glu
20 25 30
Pro Gly Ala Ala Gly Glu Pro Gly Ala Ala Gly Pro Pro Gly Ala Ala
35 40 45
Gly Ala Glu Gly Pro Ala Gly Ala Ala Gly Pro Ala Gly Ala Ala Gly
50 55 60
Ala Pro Gly Ala Ala Gly Glu Ala Gly Ala Pro Gly Glu Ala Gly Ala
65 70 75 80
Pro Gly Ala Glu Gly Pro Ala Gly Pro Glu Gly Ala Pro Gly Ala Glu
85 90 95
Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly Ala Ala
100 105
<210> 126
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 126
ggtccaccag gtgctgctgg tgctgaaggt ccagctggtg ctccaggtgc tgctggtgct 60
gctggtgaag ctggtccaga aggtgctcca ggtgaaccag gtgctgctgg tgaaccaggt 120
gctgctggtc caccaggtgc tgctggtgct gaaggtccag ctggtgctgc tggtccagct 180
ggtgctgctg gtgctccagg tgctgctggt gaagctggtg ctccaggtga agctggtgct 240
ccaggtgctg aaggtccagc tggtccagaa ggtgctccag gtgctgaagg tgctgctggt 300
gctccaggtg ctgaaggtgc tgct 324
<210> 127
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 127
Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Glu Ala Gly Pro Glu Gly
1 5 10 15
Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Glu
20 25 30
Ala Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly Glu Ala Gly Ala Ala
35 40 45
Gly Ala Glu Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly
50 55 60
Ala Pro Gly Ala Ala Gly Ala Pro Gly Ala Pro Gly Ala Ala Gly Pro
65 70 75 80
Ala Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Ala Gly Ala Glu Gly Ala Pro
100 105
<210> 128
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 128
ggtgaaccag gtccagaagg tgctgctggt gaagctggtc cagaaggtgc tgaaggtcca 60
gctggtccag ctggtgctcc aggtgctcca ggtgaagctg gtgctgctgg tgctccaggt 120
gctgaaggtg aagctggtgc tgctggtgct gaaggtccag ctggtgaagc tggtgctcca 180
ggtccaccag gtgctccagg tgctgctggt gctccaggtg ctccaggtgc tgctggtcca 240
gctggtgaac caggtccaga aggtccacca ggtgaagctg gtgctccagg tccaccaggt 300
gctgctggtg ctgaaggtgc tcca 324
<210> 129
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 129
Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly
1 5 10 15
Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Glu
20 25 30
Pro Gly Ala Ala Gly Glu Pro Gly Ala Ala Gly Pro Pro Gly Ala Glu
35 40 45
Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
50 55 60
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
65 70 75 80
Ala Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Ala Ala Gly Pro Glu
85 90 95
Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro
100 105
<210> 130
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 130
ggtccagaag gtgctccagg tccaccaggt ccagctggtg aaccaggtcc agctggtgct 60
ccaggtccac caggtgaagc tggtgctcca ggtgaaccag gtgctgctgg tgaaccaggt 120
gctgctggtc caccaggtgc tgaaggtgct gaaggtccag ctggtccagc tggtgaacca 180
ggtccagctg gtgctccagg tccaccaggt gaagctggtc cagctggtgc tccaggtgaa 240
gctggtgaac caggtccaga aggtgctgct ggtgctgctg gtccagaagg tgctgaaggt 300
ccagctggtc cagctggtgc tcca 324
<210> 131
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 131
Gly Ala Ala Gly Ala Pro Gly Ala Ala Gly Ala Ala Gly Ala Pro Gly
1 5 10 15
Pro Ala Gly Ala Ala Gly Ala Pro Gly Glu Ala Gly Pro Ala Gly Ala
20 25 30
Pro Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly Ala Ala Gly Ala Pro
35 40 45
Gly Ala Glu Gly Ala Pro Gly Glu Ala Gly Ala Ala Gly Glu Ala Gly
50 55 60
Ala Pro Gly Pro Ala Gly Ala Pro Gly Pro Glu Gly Ala Pro Gly Ala
65 70 75 80
Pro Gly Ala Pro Gly Ala Pro Gly Pro Ala Gly Ala Pro Gly Ala Pro
85 90 95
Gly Ala Pro Gly Pro Ala Gly Ala Glu Gly Ala Pro
100 105
<210> 132
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 132
ggtgctgctg gtgctccagg tgctgctggt gctgctggtg ctccaggtcc agctggtgct 60
gctggtgctc caggtgaagc tggtccagct ggtgctccag gtgctgctgg tgctccaggt 120
gctgaaggtg ctgctggtgc tccaggtgct gaaggtgctc caggtgaagc tggtgctgct 180
ggtgaagctg gtgctccagg tccagctggt gctccaggtc cagaaggtgc tccaggtgct 240
ccaggtgctc caggtgctcc aggtccagct ggtgctccag gtgctccagg tgctccaggt 300
ccagctggtg ctgaaggtgc tcca 324
<210> 133
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 133
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
1 5 10 15
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro
20 25 30
Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro
35 40 45
Gly Pro Glu Gly Pro Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala
85 90 95
Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro
100 105
<210> 134
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 134
ggtgaagctg gtccaccagg tccagctggt gctgaaggtg aagctggtcc agctggtgct 60
ccaggtgaac caggtccaga aggtccacca ggtccagctg gtgctgaagg tgaagctggt 120
ccagctggtg ctccaggtga accaggtcca gaaggtccac caggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag ctggtgctcc aggtgaagct ggtccaccag gtccagctgg tgctgaaggt 300
gaagctggtc cagctggtgc tcca 324
<210> 135
<211> 117
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 135
Gly Pro Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly
1 5 10 15
Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala
20 25 30
Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala
35 40 45
Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly
50 55 60
Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Pro
65 70 75 80
Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Glu Pro Gly Ala Pro
85 90 95
Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly
100 105 110
Pro Pro Gly Pro Ala
115
<210> 136
<211> 351
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 136
ggtccacctg gtgctccagg tgaaccaggt ccagctggtc caccaggtgc tgaaggtgct 60
ccaggtccag ctggtccaga aggtgaagct ggtgctgaag gtgaaccagg tgaagctggt 120
ccaccaggtg ctccaggtga agctggtgct gaaggtgctc caggtccaga aggtgaacca 180
ggtgaagctg gtccagaagg tgctccaggt ccagctggtg aaccaggtgc tccaggtcca 240
ccaggtgaac caggtccagc tggtgaagct ggtgaaccag gtgctccagg tccagctggt 300
gaagctggtc caccaggtgc tccaggtcca gctggtccac caggtccagc t 351
<210> 137
<211> 108
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 137
Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly
1 5 10 15
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Glu Glu Gly Glu
20 25 30
Pro Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Glu Ala Gly Ala Glu
35 40 45
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Ala Pro Gly Ala Glu Gly Glu Glu Gly Pro Pro Gly Glu Ala
85 90 95
Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly Ala Ala
100 105
<210> 138
<211> 324
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 138
ggtccagctg gtgaaccagg tccagctggt gctccaggtc caccaggtga agctggtcca 60
gctggtgctc caggtgaagc tggtgaagaa ggtgaaccag gtgctgaagg tccagctggt 120
ccagctggtg aagctggtgc tgaaggtgct ccaggtccac caggtccagc tggtgctcca 180
ggtgaagctg gtccaccagg tccagctggt gctgaaggtg aagctggtcc agctggtgct 240
ccaggtgctc caggtgctga aggtgaagaa ggtccaccag gtgaagctgg tgaaccaggt 300
gctccaggtc cagaaggtgc tgct 324
<210> 139
<211> 459
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 139
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
130 135 140
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
165 170 175
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
180 185 190
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
210 215 220
Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu
225 230 235 240
Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly
245 250 255
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
260 265 270
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro
275 280 285
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
290 295 300
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu
305 310 315 320
Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro
325 330 335
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly
340 345 350
Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu
355 360 365
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
370 375 380
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly
385 390 395 400
Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu
405 410 415
Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro
420 425 430
Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly
435 440 445
Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala
450 455
<210> 140
<211> 1377
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 140
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc tggtgaagct 360
ggtgcacccg gacccgaagg tgccgaagga gaggctggtg aacctggacc cgccggtgaa 420
ccaggacctg aaggagctcc aggtcctcct ggacccgcag gagagcccgg tcctgccggt 480
gctcctggtc cacccggaga agcaggtcca gccggagctc ctggtgaggc tggtccccca 540
ggacccgctg gagctgaagg tgaggcaggt ccagccggcg ctccaggtga gccaggacca 600
gaaggtccac caggagaagc tggagcaccc ggtcctccag gagcacccgg cgctgaagga 660
gaacccggtg ctcctggaga acccggtcca gctggtgaag ctggtgcacc cggacccgaa 720
ggtgccgaag gagaggctgg tgaacctgga cccgccggtg aaccaggacc tgaaggagct 780
ccaggtcctc ctggacccgc aggagagccc ggtcctgccg gtgctcctgg tccacccgga 840
gaagcaggtc cagccggagc tcctggtgag gctggtcccc caggacccgc tggagctgaa 900
ggtgaggcag gtccagccgg cgctccaggt gagccaggac cagaaggtcc accaggagaa 960
gctggagcac ccggtcctcc aggagcaccc ggcgctgaag gagaacccgg tgctcctgga 1020
gaacccggtc cagctggtga agctggtgca cccggacccg aaggtgccga aggagaggct 1080
ggtgaacctg gacccgccgg tgaaccagga cctgaaggag ctccaggtcc tcctggaccc 1140
gcaggagagc ccggtcctgc cggtgctcct ggtccacccg gagaagcagg tccagccgga 1200
gctcctggtg aggctggtcc cccaggaccc gctggagctg aaggtgaggc aggtccagcc 1260
ggcgctccag gtgagccagg accagaaggt ccaccaggag aagctggagc acccggtcct 1320
ccaggagcac ccggcgctga aggagaaccc ggtgctcctg gagaacccgg tccagct 1377
<210> 141
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 141
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala
20 25 30
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
35 40 45
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Pro Gly
100 105 110
Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu
115 120 125
Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Glu Ala
130 135 140
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala
165 170 175
Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu
180 185 190
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Ala
210 215 220
Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala
225 230 235 240
Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly
245 250 255
Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
260 265 270
Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro
275 280 285
Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly
290 295 300
Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro
305 310 315 320
Pro Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu
325 330 335
Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly
340 345 350
Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala
355 360 365
Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu
370 375 380
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly
385 390 395 400
Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
405 410 415
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
420 425 430
<210> 142
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 142
ggtccaccag gtgaagctgg tgctccaggt ccagaaggtg ctgaaggtga agctggtgaa 60
ccaggtccag ctggtgaacc aggtccagct ggtgctccag gtgaagctgg tccaccaggt 120
ccagctggtg ctgaaggtga agctggtcca gctggtgctc caggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 300
gctccaggtc caccaggtga agctggtcca ccaggtgaag ctggtgctcc aggtccagaa 360
ggtgctgaag gtgaagctgg tgaaccaggt ccagctggtg aaccaggtcc agctggtgct 420
ccaggtgaag ctggtccacc aggtccagct ggtgctgaag gtgaagctgg tccagctggt 480
gctccaggtg aaccaggtcc agaaggtcca ccaggtgaag ctggtgctcc aggtccacca 540
ggtgctccag gtgctgaagg tgaaccaggt ccagaaggtg ctccaggtcc accaggtcca 600
gctggtgaac caggtccagc tggtgctcca ggtccaccag gtgaagctgg tccaccaggt 660
gaagctggtg ctccaggtcc agaaggtgct gaaggtgaag ctggtgaacc aggtccagct 720
ggtgaaccag gtccagctgg tgctccaggt gaagctggtc caccaggtcc agctggtgct 780
gaaggtgaag ctggtccagc tggtgctcca ggtgaaccag gtccagaagg tccaccaggt 840
gaagctggtg ctccaggtcc accaggtgct ccaggtgctg aaggtgaacc aggtccagaa 900
ggtgctccag gtccaccagg tccagctggt gaaccaggtc cagctggtgc tccaggtcca 960
ccaggtgaag ctggtccacc aggtgaagct ggtgctccag gtccagaagg tgctgaaggt 1020
gaagctggtg aaccaggtcc agctggtgaa ccaggtccag ctggtgctcc aggtgaagct 1080
ggtccaccag gtccagctgg tgctgaaggt gaagctggtc cagctggtgc tccaggtgaa 1140
ccaggtccag aaggtccacc aggtgaagct ggtgctccag gtccaccagg tgctccaggt 1200
gctgaaggtg aaccaggtcc agaaggtgct ccaggtccac caggtccagc tggtgaacca 1260
ggtccagctg gtgctccagg tccaccaggt gaagct 1296
<210> 143
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 143
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
1 5 10 15
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu
20 25 30
Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro
35 40 45
Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly
100 105 110
Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu
115 120 125
Ala Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro
130 135 140
Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly
145 150 155 160
Glu Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala
165 170 175
Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu
180 185 190
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
210 215 220
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
225 230 235 240
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly
245 250 255
Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Glu
260 265 270
Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro
275 280 285
Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly
290 295 300
Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro
305 310 315 320
Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro
325 330 335
Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly
340 345 350
Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu
355 360 365
Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Pro Glu
370 375 380
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly
385 390 395 400
Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
405 410 415
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
420 425 430
<210> 144
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 144
ggtccagctg gtgctccagg tgaagctggt ccaccaggtc cagctggtgc tgaaggtgaa 60
gctggtccag ctggtgctcc aggtccacca ggtgaagctg gtgctccagg tccagaaggt 120
gctgaaggtg aagctggtga accaggtcca gctggtgaac caggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 300
gctccaggtc caccaggtga agctggtcca gctggtgctc caggtgaagc tggtccacca 360
ggtccagctg gtgctgaagg tgaagctggt ccagctggtg ctccaggtcc accaggtgaa 420
gctggtgctc caggtccaga aggtgctgaa ggtgaagctg gtgaaccagg tccagctggt 480
gaaccaggtg aaccaggtcc agaaggtcca ccaggtgaag ctggtgctcc aggtccacca 540
ggtgctccag gtgctgaagg tgaaccaggt ccagaaggtg ctccaggtcc accaggtcca 600
gctggtgaac caggtccagc tggtgctcca ggtccaccag gtgaagctgg tccagctggt 660
gctccaggtg aagctggtcc accaggtcca gctggtgctg aaggtgaagc tggtccagct 720
ggtgctccag gtccaccagg tgaagctggt gctccaggtc cagaaggtgc tgaaggtgaa 780
gctggtgaac caggtccagc tggtgaacca ggtgaaccag gtccagaagg tccaccaggt 840
gaagctggtg ctccaggtcc accaggtgct ccaggtgctg aaggtgaacc aggtccagaa 900
ggtgctccag gtccaccagg tccagctggt gaaccaggtc cagctggtgc tccaggtcca 960
ccaggtgaag ctggtccagc tggtgctcca ggtgaagctg gtccaccagg tccagctggt 1020
gctgaaggtg aagctggtcc agctggtgct ccaggtccac caggtgaagc tggtgctcca 1080
ggtccagaag gtgctgaagg tgaagctggt gaaccaggtc cagctggtga accaggtgaa 1140
ccaggtccag aaggtccacc aggtgaagct ggtgctccag gtccaccagg tgctccaggt 1200
gctgaaggtg aaccaggtcc agaaggtgct ccaggtccac caggtccagc tggtgaacca 1260
ggtccagctg gtgctccagg tccaccaggt gaagct 1296
<210> 145
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 145
Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly
1 5 10 15
Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Pro
20 25 30
Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
35 40 45
Gly Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly
50 55 60
Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu
65 70 75 80
Ala Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu
85 90 95
Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly
100 105 110
Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala
115 120 125
Pro Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Pro Glu Gly Pro Pro
130 135 140
Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly
145 150 155 160
Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu
165 170 175
Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Pro
180 185 190
Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly
195 200 205
Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro
210 215 220
Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro
225 230 235 240
Gly Glu Ala Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
245 250 255
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro
260 265 270
Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala
275 280 285
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly
290 295 300
Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro
305 310 315 320
Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala
325 330 335
Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly
340 345 350
Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro
355 360 365
Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro
370 375 380
Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly
385 390 395 400
Pro Pro Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro
405 410 415
Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro
420 425 430
<210> 146
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 146
ggtccagaag gtgctccagg tccaccaggt ccagctggtg aaccaggtcc agctggtgct 60
ccaggtccac caggtgaagc tggtgaacca ggtccagaag gtccaccagg tgaagctggt 120
gctccaggtc caccaggtgc tccaggtgct gaaggtgaac caggtccaga aggtgctcca 180
ggtccaccag gtccagctgg tgaaccaggt ccagctggtg ctccaggtcc accaggtgaa 240
gctggtccac caggtgaagc tggtgctcca ggtccagaag gtgctgaagg tgaagctggt 300
gaaccaggtc cagctggtga accaggtcca gaaggtgctc caggtccacc aggtccagct 360
ggtgaaccag gtccagctgg tgctccaggt ccaccaggtg aagctggtga accaggtcca 420
gaaggtccac caggtgaagc tggtgctcca ggtccaccag gtgctccagg tgctgaaggt 480
gaaccaggtc cagaaggtgc tccaggtcca ccaggtccag ctggtgaacc aggtccagct 540
ggtgctccag gtccaccagg tgaagctggt ccaccaggtg aagctggtgc tccaggtcca 600
gaaggtgctg aaggtgaagc tggtgaacca ggtccagctg gtgaaccagg tccagaaggt 660
gctccaggtc caccaggtcc agctggtgaa ccaggtccag ctggtgctcc aggtccacca 720
ggtgaagctg gtgaaccagg tccagaaggt ccaccaggtg aagctggtgc tccaggtcca 780
ccaggtgctc caggtgctga aggtgaacca ggtccagaag gtgctccagg tccaccaggt 840
ccagctggtg aaccaggtcc agctggtgct ccaggtccac caggtgaagc tggtccacca 900
ggtgaagctg gtgctccagg tccagaaggt gctgaaggtg aagctggtga accaggtcca 960
gctggtgaac caggtccaga aggtgctcca ggtccaccag gtccagctgg tgaaccaggt 1020
ccagctggtg ctccaggtcc accaggtgaa gctggtgaac caggtccaga aggtccacca 1080
ggtgaagctg gtgctccagg tccaccaggt gctccaggtg ctgaaggtga accaggtcca 1140
gaaggtgctc caggtccacc aggtccagct ggtgaaccag gtccagctgg tgctccaggt 1200
ccaccaggtg aagctggtcc accaggtgaa gctggtgctc caggtccaga aggtgctgaa 1260
ggtgaagctg gtgaaccagg tccagctggt gaacca 1296
<210> 147
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 147
Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly
1 5 10 15
Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu
20 25 30
Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala
35 40 45
Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly
50 55 60
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro
65 70 75 80
Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu
85 90 95
Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Glu Gly
100 105 110
Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro
115 120 125
Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala
130 135 140
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly
145 150 155 160
Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro
165 170 175
Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala
180 185 190
Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly
195 200 205
Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Glu Gly Ala Glu Gly Glu
210 215 220
Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro
225 230 235 240
Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly
245 250 255
Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro
260 265 270
Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro
275 280 285
Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly
290 295 300
Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu
305 310 315 320
Pro Gly Pro Ala Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro
325 330 335
Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly
340 345 350
Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu
355 360 365
Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala
370 375 380
Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly
385 390 395 400
Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala
405 410 415
Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala
420 425 430
<210> 148
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 148
ggtccagaag gtgctgaagg tgaagctggt gaaccaggtc cagctggtga accaggtcca 60
gaaggtgctc caggtccacc aggtccagct ggtgaaccag gtccagctgg tgctccaggt 120
ccaccaggtg aagctggtcc agctggtgct ccaggtgaag ctggtccacc aggtccagct 180
ggtgctgaag gtgaagctgg tccagctggt gctccaggtg aaccaggtcc agaaggtcca 240
ccaggtgaag ctggtgctcc aggtccacca ggtgctccag gtgctgaagg tgaaccaggt 300
gctccaggtg aaccaggtcc agctggtcca gaaggtgctg aaggtgaagc tggtgaacca 360
ggtccagctg gtgaaccagg tccagaaggt gctccaggtc caccaggtcc agctggtgaa 420
ccaggtccag ctggtgctcc aggtccacca ggtgaagctg gtccagctgg tgctccaggt 480
gaagctggtc caccaggtcc agctggtgct gaaggtgaag ctggtccagc tggtgctcca 540
ggtgaaccag gtccagaagg tccaccaggt gaagctggtg ctccaggtcc accaggtgct 600
ccaggtgctg aaggtgaacc aggtgctcca ggtgaaccag gtccagctgg tccagaaggt 660
gctgaaggtg aagctggtga accaggtcca gctggtgaac caggtccaga aggtgctcca 720
ggtccaccag gtccagctgg tgaaccaggt ccagctggtg ctccaggtcc accaggtgaa 780
gctggtccag ctggtgctcc aggtgaagct ggtccaccag gtccagctgg tgctgaaggt 840
gaagctggtc cagctggtgc tccaggtgaa ccaggtccag aaggtccacc aggtgaagct 900
ggtgctccag gtccaccagg tgctccaggt gctgaaggtg aaccaggtgc tccaggtgaa 960
ccaggtccag ctggtccaga aggtgctgaa ggtgaagctg gtgaaccagg tccagctggt 1020
gaaccaggtc cagaaggtgc tccaggtcca ccaggtccag ctggtgaacc aggtccagct 1080
ggtgctccag gtccaccagg tgaagctggt ccagctggtg ctccaggtga agctggtcca 1140
ccaggtccag ctggtgctga aggtgaagct ggtccagctg gtgctccagg tgaaccaggt 1200
ccagaaggtc caccaggtga agctggtgct ccaggtccac caggtgctcc aggtgctgaa 1260
ggtgaaccag gtgctccagg tgaaccaggt ccagct 1296
<210> 149
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 149
Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly
1 5 10 15
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro
20 25 30
Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro
35 40 45
Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly
50 55 60
Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro
65 70 75 80
Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu
85 90 95
Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Ala Gly
100 105 110
Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro
115 120 125
Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu
130 135 140
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly
145 150 155 160
Pro Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro
165 170 175
Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Glu Ala
180 185 190
Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly
195 200 205
Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Ala Gly Glu Pro Gly Pro
210 215 220
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro
225 230 235 240
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
245 250 255
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro
260 265 270
Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro
275 280 285
Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly
290 295 300
Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu
305 310 315 320
Pro Gly Pro Ala Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
325 330 335
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
340 345 350
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
355 360 365
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu
370 375 380
Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly
385 390 395 400
Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala
405 410 415
Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala
420 425 430
<210> 150
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 150
ggtccagctg gtgaaccagg tccagctggt gctccaggtc caccaggtga agctggtcca 60
gctggtgctc caggtgaagc tggtccacca ggtccagctg gtgctgaagg tgaagctggt 120
ccagctggtg ctccaggtga accaggtcca gaaggtccac caggtccaga aggtgctgaa 180
ggtgaagctg gtgaaccagg tccagctggt gaaccaggtc cagaaggtgc tccaggtcca 240
ccaggtgaag ctggtgctcc aggtccacca ggtgctccag gtgctgaagg tgaaccaggt 300
gctccaggtg aaccaggtcc agctggtcca gctggtgaac caggtccagc tggtgctcca 360
ggtccaccag gtgaagctgg tccagctggt gctccaggtg aagctggtcc accaggtcca 420
gctggtgctg aaggtgaagc tggtccagct ggtgctccag gtgaaccagg tccagaaggt 480
ccaccaggtc cagaaggtgc tgaaggtgaa gctggtgaac caggtccagc tggtgaacca 540
ggtccagaag gtgctccagg tccaccaggt gaagctggtg ctccaggtcc accaggtgct 600
ccaggtgctg aaggtgaacc aggtgctcca ggtgaaccag gtccagctgg tccagctggt 660
gaaccaggtc cagctggtgc tccaggtcca ccaggtgaag ctggtccagc tggtgctcca 720
ggtgaagctg gtccaccagg tccagctggt gctgaaggtg aagctggtcc agctggtgct 780
ccaggtgaac caggtccaga aggtccacca ggtccagaag gtgctgaagg tgaagctggt 840
gaaccaggtc cagctggtga accaggtcca gaaggtgctc caggtccacc aggtgaagct 900
ggtgctccag gtccaccagg tgctccaggt gctgaaggtg aaccaggtgc tccaggtgaa 960
ccaggtccag ctggtccagc tggtgaacca ggtccagctg gtgctccagg tccaccaggt 1020
gaagctggtc cagctggtgc tccaggtgaa gctggtccac caggtccagc tggtgctgaa 1080
ggtgaagctg gtccagctgg tgctccaggt gaaccaggtc cagaaggtcc accaggtcca 1140
gaaggtgctg aaggtgaagc tggtgaacca ggtccagctg gtgaaccagg tccagaaggt 1200
gctccaggtc caccaggtga agctggtgct ccaggtccac caggtgctcc aggtgctgaa 1260
ggtgaaccag gtgctccagg tgaaccaggt ccagct 1296
<210> 151
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 151
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
1 5 10 15
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala
20 25 30
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
35 40 45
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly
50 55 60
Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro
65 70 75 80
Ala Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro
85 90 95
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly
100 105 110
Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
115 120 125
Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala
130 135 140
Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly
145 150 155 160
Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala
165 170 175
Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Ala
180 185 190
Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly
195 200 205
Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala
210 215 220
Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu
225 230 235 240
Gly Pro Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly
245 250 255
Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Glu
260 265 270
Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro
275 280 285
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Ala Gly Glu Pro Gly
290 295 300
Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala
305 310 315 320
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
325 330 335
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
340 345 350
Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu
355 360 365
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro
370 375 380
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
385 390 395 400
Glu Pro Gly Pro Ala Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala
405 410 415
Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala
420 425 430
<210> 152
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 152
ggtccaccag gtccagctgg tgctgaaggt gaagctggtc cagctggtgc tccaggtgaa 60
ccaggtccag aaggtccacc aggtccagaa ggtgctgaag gtgaagctgg tgaaccaggt 120
ccagctggtg aaccaggtcc agaaggtgct ccaggtccac caggtgaagc tggtgctcca 180
ggtccaccag gtgctccagg tgctgaaggt gaaccaggtg ctccaggtga accaggtcca 240
gctggtccag ctggtgaacc aggtccagct ggtgctccag gtccaccagg tgaagctggt 300
ccagctggtg ctccaggtga agctggtcca ccaggtccag ctggtgctga aggtgaagct 360
ggtccagctg gtgctccagg tgaaccaggt ccagaaggtc caccaggtcc agaaggtgct 420
gaaggtgaag ctggtgaacc aggtccagct ggtgaaccag gtccagaagg tgctccaggt 480
ccaccaggtg aagctggtgc tccaggtcca ccaggtgctc caggtgctga aggtgaacca 540
ggtgctccag gtgaaccagg tccagctggt ccagctggtg aaccaggtcc agctggtgct 600
ccaggtccac caggtgaagc tggtccagct ggtgctccag gtgaagctgg tccaccaggt 660
ccagctggtg ctgaaggtga agctggtcca gctggtgctc caggtgaacc aggtccagaa 720
ggtccaccag gtccagaagg tgctgaaggt gaagctggtg aaccaggtcc agctggtgaa 780
ccaggtccag aaggtgctcc aggtccacca ggtgaagctg gtgctccagg tccaccaggt 840
gctccaggtg ctgaaggtga accaggtgct ccaggtgaac caggtccagc tggtccagct 900
ggtgaaccag gtccagctgg tgctccaggt ccaccaggtg aagctggtcc agctggtgct 960
ccaggtgaag ctggtccacc aggtccagct ggtgctgaag gtgaagctgg tccagctggt 1020
gctccaggtg aaccaggtcc agaaggtcca ccaggtccag aaggtgctga aggtgaagct 1080
ggtgaaccag gtccagctgg tgaaccaggt ccagaaggtg ctccaggtcc accaggtgaa 1140
gctggtgctc caggtccacc aggtgctcca ggtgctgaag gtgaaccagg tgctccaggt 1200
gaaccaggtc cagctggtcc agctggtgaa ccaggtccag ctggtgctcc aggtccacca 1260
ggtgaagctg gtccagctgg tgctccaggt gaagct 1296
<210> 153
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 153
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
1 5 10 15
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Pro Gly
100 105 110
Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
115 120 125
Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro
130 135 140
Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly
145 150 155 160
Glu Ala Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala
165 170 175
Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu
180 185 190
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala
210 215 220
Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu
225 230 235 240
Gly Pro Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly
245 250 255
Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Glu
260 265 270
Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro
275 280 285
Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly
290 295 300
Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro
305 310 315 320
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
325 330 335
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
340 345 350
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
355 360 365
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Pro Glu
370 375 380
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly
385 390 395 400
Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
405 410 415
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
420 425 430
<210> 154
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 154
ggtccaccag gtccagctgg tgctgaaggt gaagctggtc cagctggtgc tccaggtgaa 60
ccaggtccag aaggtccacc aggtccagaa ggtgctccag gtccaccagg tccagctggt 120
gaaccaggtc cagctggtgc tccaggtcca ccaggtgaag ctggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 300
gctccaggtc caccaggtga agctggtcca ccaggtccag ctggtgctga aggtgaagct 360
ggtccagctg gtgctccagg tgaaccaggt ccagaaggtc caccaggtcc agaaggtgct 420
ccaggtccac caggtccagc tggtgaacca ggtccagctg gtgctccagg tccaccaggt 480
gaagctggtg aaccaggtcc agaaggtcca ccaggtgaag ctggtgctcc aggtccacca 540
ggtgctccag gtgctgaagg tgaaccaggt ccagaaggtg ctccaggtcc accaggtcca 600
gctggtgaac caggtccagc tggtgctcca ggtccaccag gtgaagctgg tccaccaggt 660
ccagctggtg ctgaaggtga agctggtcca gctggtgctc caggtgaacc aggtccagaa 720
ggtccaccag gtccagaagg tgctccaggt ccaccaggtc cagctggtga accaggtcca 780
gctggtgctc caggtccacc aggtgaagct ggtgaaccag gtccagaagg tccaccaggt 840
gaagctggtg ctccaggtcc accaggtgct ccaggtgctg aaggtgaacc aggtccagaa 900
ggtgctccag gtccaccagg tccagctggt gaaccaggtc cagctggtgc tccaggtcca 960
ccaggtgaag ctggtccacc aggtccagct ggtgctgaag gtgaagctgg tccagctggt 1020
gctccaggtg aaccaggtcc agaaggtcca ccaggtccag aaggtgctcc aggtccacca 1080
ggtccagctg gtgaaccagg tccagctggt gctccaggtc caccaggtga agctggtgaa 1140
ccaggtccag aaggtccacc aggtgaagct ggtgctccag gtccaccagg tgctccaggt 1200
gctgaaggtg aaccaggtcc agaaggtgct ccaggtccac caggtccagc tggtgaacca 1260
ggtccagctg gtgctccagg tccaccaggt gaagct 1296
<210> 155
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 155
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly
1 5 10 15
Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu
20 25 30
Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu
35 40 45
Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly
50 55 60
Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu
65 70 75 80
Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro
115 120 125
Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala
130 135 140
Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly
145 150 155 160
Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro
165 170 175
Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro
180 185 190
Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly
195 200 205
Pro Pro Gly Ala Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
210 215 220
Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu
225 230 235 240
Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly
245 250 255
Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu
260 265 270
Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro
275 280 285
Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly
290 295 300
Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala
305 310 315 320
Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro
325 330 335
Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly
340 345 350
Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu
355 360 365
Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala
370 375 380
Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly
385 390 395 400
Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro
405 410 415
Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala
420 425 430
<210> 156
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 156
ggtgctccag gtgaaccagg tccagctggt ccaccaggtg ctgaaggtgc tccaggtcca 60
gctggtccag aaggtgaagc tggtgctgaa ggtgaaccag gtgaagctgg tccaccaggt 120
gctccaggtg aagctggtgc tgaaggtgct ccaggtccag aaggtgaacc aggtgaagct 180
ggtccagaag gtgctccagg tccagctggt gaaccaggtg ctccaggtga agctggtgaa 240
ccaggtccac caggtccagc tggtgctcca ggtccagctg gtgaaccagg tgaagctggt 300
ccaccaggtg ctccaggtcc agctggtgct ccaggtgaac caggtccagc tggtccacca 360
ggtgctgaag gtgctccagg tccagctggt ccagaaggtg aagctggtgc tgaaggtgaa 420
ccaggtgaag ctggtccacc aggtgctcca ggtgaagctg gtgctgaagg tgctccaggt 480
ccagaaggtg aaccaggtga agctggtcca gaaggtgctc caggtccagc tggtgaacca 540
ggtgctccag gtgaagctgg tgaaccaggt ccaccaggtc cagctggtgc tccaggtcca 600
gctggtgaac caggtgaagc tggtccacca ggtgctccag gtccagctgg tgctccaggt 660
gaaccaggtc cagctggtcc accaggtgct gaaggtgctc caggtccagc tggtccagaa 720
ggtgaagctg gtgctgaagg tgaaccaggt gaagctggtc caccaggtgc tccaggtgaa 780
gctggtgctg aaggtgctcc aggtccagaa ggtgaaccag gtgaagctgg tccagaaggt 840
gctccaggtc cagctggtga accaggtgct ccaggtgaag ctggtgaacc aggtccacca 900
ggtccagctg gtgctccagg tccagctggt gaaccaggtg aagctggtcc accaggtgct 960
ccaggtccag ctggtgctcc aggtgaacca ggtccagctg gtccaccagg tgctgaaggt 1020
gctccaggtc cagctggtcc agaaggtgaa gctggtgctg aaggtgaacc aggtgaagct 1080
ggtccaccag gtgctccagg tgaagctggt gctgaaggtg ctccaggtcc agaaggtgaa 1140
ccaggtgaag ctggtccaga aggtgctcca ggtccagctg gtgaaccagg tgctccaggt 1200
gaagctggtg aaccaggtcc accaggtcca gctggtgctc caggtccagc tggtgaacca 1260
ggtgaagctg gtccaccagg tgctccaggt ccagct 1296
<210> 157
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 157
Gly Ala Ala Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly
1 5 10 15
Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Ala Glu Gly Ala
20 25 30
Ala Gly Glu Ala Gly Ala Pro Gly Ala Glu Gly Glu Ala Gly Ala Glu
35 40 45
Gly Ala Pro Gly Pro Glu Gly Ala Pro Gly Ala Ala Gly Pro Ala Gly
50 55 60
Ala Ala Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu
65 70 75 80
Ala Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala
85 90 95
Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Ala Ala Gly
100 105 110
Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Ala
115 120 125
Glu Gly Ala Pro Gly Pro Ala Gly Ala Glu Gly Ala Ala Gly Glu Ala
130 135 140
Gly Ala Pro Gly Ala Glu Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly
145 150 155 160
Pro Glu Gly Ala Pro Gly Ala Ala Gly Pro Ala Gly Ala Ala Gly Ala
165 170 175
Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Glu Pro
180 185 190
Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly
195 200 205
Ala Pro Gly Glu Ala Gly Glu Pro Gly Ala Ala Gly Pro Ala Gly Ala
210 215 220
Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro
225 230 235 240
Gly Pro Ala Gly Ala Glu Gly Ala Ala Gly Glu Ala Gly Ala Pro Gly
245 250 255
Ala Glu Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Ala
260 265 270
Pro Gly Ala Ala Gly Pro Ala Gly Ala Ala Gly Ala Glu Gly Ala Pro
275 280 285
Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Glu Pro Gly Glu Ala Gly
290 295 300
Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu
305 310 315 320
Ala Gly Glu Pro Gly Ala Ala Gly Pro Ala Gly Ala Pro Gly Pro Ala
325 330 335
Gly Glu Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly
340 345 350
Ala Glu Gly Ala Ala Gly Glu Ala Gly Ala Pro Gly Ala Glu Gly Glu
355 360 365
Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Ala Pro Gly Ala Ala
370 375 380
Gly Pro Ala Gly Ala Ala Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly
385 390 395 400
Pro Glu Gly Glu Ala Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala
405 410 415
Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro
420 425 430
<210> 158
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 158
ggtgctgctg gtccagctgg tgctccaggt ccagctggtg aaccaggtga agctggtgct 60
gaaggtgctc caggtccagc tggtgctgaa ggtgctgctg gtgaagctgg tgctccaggt 120
gctgaaggtg aagctggtgc tgaaggtgct ccaggtccag aaggtgctcc aggtgctgct 180
ggtccagctg gtgctgctgg tgctgaaggt gctccaggtc cagctggtcc agaaggtgaa 240
gctggtgaac caggtgaagc tggtccagaa ggtgctccag gtccagctgg tgaaccaggt 300
gctccaggtg aagctggtga accaggtgct gctggtccag ctggtgctcc aggtccagct 360
ggtgaaccag gtgaagctgg tgctgaaggt gctccaggtc cagctggtgc tgaaggtgct 420
gctggtgaag ctggtgctcc aggtgctgaa ggtgaagctg gtgctgaagg tgctccaggt 480
ccagaaggtg ctccaggtgc tgctggtcca gctggtgctg ctggtgctga aggtgctcca 540
ggtccagctg gtccagaagg tgaagctggt gaaccaggtg aagctggtcc agaaggtgct 600
ccaggtccag ctggtgaacc aggtgctcca ggtgaagctg gtgaaccagg tgctgctggt 660
ccagctggtg ctccaggtcc agctggtgaa ccaggtgaag ctggtgctga aggtgctcca 720
ggtccagctg gtgctgaagg tgctgctggt gaagctggtg ctccaggtgc tgaaggtgaa 780
gctggtgctg aaggtgctcc aggtccagaa ggtgctccag gtgctgctgg tccagctggt 840
gctgctggtg ctgaaggtgc tccaggtcca gctggtccag aaggtgaagc tggtgaacca 900
ggtgaagctg gtccagaagg tgctccaggt ccagctggtg aaccaggtgc tccaggtgaa 960
gctggtgaac caggtgctgc tggtccagct ggtgctccag gtccagctgg tgaaccaggt 1020
gaagctggtg ctgaaggtgc tccaggtcca gctggtgctg aaggtgctgc tggtgaagct 1080
ggtgctccag gtgctgaagg tgaagctggt gctgaaggtg ctccaggtcc agaaggtgct 1140
ccaggtgctg ctggtccagc tggtgctgct ggtgctgaag gtgctccagg tccagctggt 1200
ccagaaggtg aagctggtga accaggtgaa gctggtccag aaggtgctcc aggtccagct 1260
ggtgaaccag gtgctccagg tgaagctggt gaacca 1296
<210> 159
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 159
Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly
1 5 10 15
Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
20 25 30
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
35 40 45
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
50 55 60
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
65 70 75 80
Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
85 90 95
Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Ala Pro Gly
100 105 110
Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu
115 120 125
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
130 135 140
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu
165 170 175
Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro
180 185 190
Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly
195 200 205
Glu Pro Gly Ala Pro Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly Ala
210 215 220
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
225 230 235 240
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
245 250 255
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
260 265 270
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
275 280 285
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
290 295 300
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
305 310 315 320
Pro Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala
325 330 335
Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly
340 345 350
Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro
355 360 365
Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro
370 375 380
Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly
385 390 395 400
Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro
405 410 415
Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro
420 425 430
<210> 160
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 160
ggtgctccag gtccagaagg tgctgaaggt gaagctggtg aaccaggtcc agctggtgaa 60
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 120
gctccaggtc caccaggtga agctggtcca gctggtgctc caggtgaagc tggtccacca 180
ggtccagctg gtgctgaagg tgaagctggt ccagctggtg ctccaggtga accaggtcca 240
gaaggtccac caggtgaagc tggtgctcca ggtccaccag gtgctccagg tgctgaaggt 300
gaaccaggtg ctccaggtga accaggtgct ccaggtccag aaggtgctga aggtgaagct 360
ggtgaaccag gtccagctgg tgaaccaggt ccagaaggtg ctccaggtcc accaggtcca 420
gctggtgaac caggtccagc tggtgctcca ggtccaccag gtgaagctgg tccagctggt 480
gctccaggtg aagctggtcc accaggtcca gctggtgctg aaggtgaagc tggtccagct 540
ggtgctccag gtgaaccagg tccagaaggt ccaccaggtg aagctggtgc tccaggtcca 600
ccaggtgctc caggtgctga aggtgaacca ggtgctccag gtgaaccagg tgctccaggt 660
ccagaaggtg ctgaaggtga agctggtgaa ccaggtccag ctggtgaacc aggtccagaa 720
ggtgctccag gtccaccagg tccagctggt gaaccaggtc cagctggtgc tccaggtcca 780
ccaggtgaag ctggtccagc tggtgctcca ggtgaagctg gtccaccagg tccagctggt 840
gctgaaggtg aagctggtcc agctggtgct ccaggtgaac caggtccaga aggtccacca 900
ggtgaagctg gtgctccagg tccaccaggt gctccaggtg ctgaaggtga accaggtgct 960
ccaggtgaac caggtgctcc aggtccagaa ggtgctgaag gtgaagctgg tgaaccaggt 1020
ccagctggtg aaccaggtcc agaaggtgct ccaggtccac caggtccagc tggtgaacca 1080
ggtccagctg gtgctccagg tccaccaggt gaagctggtc cagctggtgc tccaggtgaa 1140
gctggtccac caggtccagc tggtgctgaa ggtgaagctg gtccagctgg tgctccaggt 1200
gaaccaggtc cagaaggtcc accaggtgaa gctggtgctc caggtccacc aggtgctcca 1260
ggtgctgaag gtgaaccagg tgctccaggt gaacca 1296
<210> 161
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 161
Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Glu Glu Gly Pro Glu Gly
1 5 10 15
Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Ala
20 25 30
Glu Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Ala Pro
35 40 45
Gly Pro Glu Gly Ala Ala Gly Pro Pro Gly Ala Glu Gly Glu Ala Gly
50 55 60
Glu Ala Gly Glu Ala Gly Pro Ala Gly Glu Glu Gly Pro Pro Gly Ala
65 70 75 80
Pro Gly Pro Pro Gly Glu Ala Gly Glu Glu Gly Ala Pro Gly Ala Glu
85 90 95
Gly Glu Ala Gly Pro Pro Gly Ala Glu Gly Pro Ala Gly Glu Pro Gly
100 105 110
Pro Glu Gly Ala Ala Gly Glu Glu Gly Pro Glu Gly Ala Glu Gly Pro
115 120 125
Ala Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Ala Glu Gly Glu Glu
130 135 140
Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly
145 150 155 160
Ala Ala Gly Pro Pro Gly Ala Glu Gly Glu Ala Gly Glu Ala Gly Glu
165 170 175
Ala Gly Pro Ala Gly Glu Glu Gly Pro Pro Gly Ala Pro Gly Pro Pro
180 185 190
Gly Glu Ala Gly Glu Glu Gly Ala Pro Gly Ala Glu Gly Glu Ala Gly
195 200 205
Pro Pro Gly Ala Glu Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
210 215 220
Ala Gly Glu Glu Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly Pro Ala
225 230 235 240
Gly Ala Pro Gly Ala Pro Gly Ala Glu Gly Glu Glu Gly Pro Pro Gly
245 250 255
Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly Ala Ala Gly Pro
260 265 270
Pro Gly Ala Glu Gly Glu Ala Gly Glu Ala Gly Glu Ala Gly Pro Ala
275 280 285
Gly Glu Glu Gly Pro Pro Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly
290 295 300
Glu Glu Gly Ala Pro Gly Ala Glu Gly Glu Ala Gly Pro Pro Gly Ala
305 310 315 320
Glu Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Glu Glu
325 330 335
Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro Gly
340 345 350
Ala Pro Gly Ala Glu Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Glu
355 360 365
Pro Gly Ala Pro Gly Pro Glu Gly Ala Ala Gly Pro Pro Gly Ala Glu
370 375 380
Gly Glu Ala Gly Glu Ala Gly Glu Ala Gly Pro Ala Gly Glu Glu Gly
385 390 395 400
Pro Pro Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Glu Glu Gly Ala
405 410 415
Pro Gly Ala Glu Gly Glu Ala Gly Pro Pro Gly Ala Glu Gly Pro Ala
420 425 430
<210> 162
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 162
ggtgaaccag gtccagaagg tgctgctggt gaagaaggtc cagaaggtgc tgaaggtcca 60
gctggtccag ctggtgctcc aggtgctcca ggtgctgaag gtgaagaagg tccaccaggt 120
gaagctggtg aaccaggtgc tccaggtcca gaaggtgctg ctggtccacc aggtgctgaa 180
ggtgaagctg gtgaagctgg tgaagctggt ccagctggtg aagaaggtcc accaggtgct 240
ccaggtccac caggtgaagc tggtgaagaa ggtgctccag gtgctgaagg tgaagctggt 300
ccaccaggtg ctgaaggtcc agctggtgaa ccaggtccag aaggtgctgc tggtgaagaa 360
ggtccagaag gtgctgaagg tccagctggt ccagctggtg ctccaggtgc tccaggtgct 420
gaaggtgaag aaggtccacc aggtgaagct ggtgaaccag gtgctccagg tccagaaggt 480
gctgctggtc caccaggtgc tgaaggtgaa gctggtgaag ctggtgaagc tggtccagct 540
ggtgaagaag gtccaccagg tgctccaggt ccaccaggtg aagctggtga agaaggtgct 600
ccaggtgctg aaggtgaagc tggtccacca ggtgctgaag gtccagctgg tgaaccaggt 660
ccagaaggtg ctgctggtga agaaggtcca gaaggtgctg aaggtccagc tggtccagct 720
ggtgctccag gtgctccagg tgctgaaggt gaagaaggtc caccaggtga agctggtgaa 780
ccaggtgctc caggtccaga aggtgctgct ggtccaccag gtgctgaagg tgaagctggt 840
gaagctggtg aagctggtcc agctggtgaa gaaggtccac caggtgctcc aggtccacca 900
ggtgaagctg gtgaagaagg tgctccaggt gctgaaggtg aagctggtcc accaggtgct 960
gaaggtccag ctggtgaacc aggtccagaa ggtgctgctg gtgaagaagg tccagaaggt 1020
gctgaaggtc cagctggtcc agctggtgct ccaggtgctc caggtgctga aggtgaagaa 1080
ggtccaccag gtgaagctgg tgaaccaggt gctccaggtc cagaaggtgc tgctggtcca 1140
ccaggtgctg aaggtgaagc tggtgaagct ggtgaagctg gtccagctgg tgaagaaggt 1200
ccaccaggtg ctccaggtcc accaggtgaa gctggtgaag aaggtgctcc aggtgctgaa 1260
ggtgaagctg gtccaccagg tgctgaaggt ccagct 1296
<210> 163
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 163
Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Glu Ala Gly Ala Pro Gly
1 5 10 15
Pro Glu Gly Ala Ala Gly Glu Pro Gly Pro Glu Gly Glu Glu Gly Glu
20 25 30
Ala Gly Ala Pro Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Pro Ala
35 40 45
Gly Pro Pro Gly Ala Ala Gly Pro Ala Gly Ala Glu Gly Glu Glu Gly
50 55 60
Glu Pro Gly Glu Pro Gly Pro Ala Gly Ala Glu Gly Pro Pro Gly Ala
65 70 75 80
Ala Gly Pro Ala Gly Pro Glu Gly Pro Glu Gly Ala Ala Gly Ala Glu
85 90 95
Gly Glu Glu Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Glu Ala Gly
100 105 110
Pro Pro Gly Glu Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Ala Gly Glu Pro Gly Pro Glu Gly Glu Glu Gly Glu Ala Gly Ala Pro
130 135 140
Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly
145 150 155 160
Ala Ala Gly Pro Ala Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Glu
165 170 175
Pro Gly Pro Ala Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly Pro Ala
180 185 190
Gly Pro Glu Gly Pro Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly
195 200 205
Glu Ala Gly Pro Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Glu
210 215 220
Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Ala Gly Glu Pro
225 230 235 240
Gly Pro Glu Gly Glu Glu Gly Glu Ala Gly Ala Pro Gly Glu Glu Gly
245 250 255
Pro Pro Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly Ala Ala Gly Pro
260 265 270
Ala Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Glu Pro Gly Pro Ala
275 280 285
Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly Pro Ala Gly Pro Glu Gly
290 295 300
Pro Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly Glu Ala Gly Pro
305 310 315 320
Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Glu Ala
325 330 335
Gly Ala Pro Gly Pro Glu Gly Ala Ala Gly Glu Pro Gly Pro Glu Gly
340 345 350
Glu Glu Gly Glu Ala Gly Ala Pro Gly Glu Glu Gly Pro Pro Gly Glu
355 360 365
Ala Gly Pro Ala Gly Pro Pro Gly Ala Ala Gly Pro Ala Gly Ala Glu
370 375 380
Gly Glu Glu Gly Glu Pro Gly Glu Pro Gly Pro Ala Gly Ala Glu Gly
385 390 395 400
Pro Pro Gly Ala Ala Gly Pro Ala Gly Pro Glu Gly Pro Glu Gly Ala
405 410 415
Ala Gly Ala Glu Gly Glu Glu Gly Glu Ala Gly Pro Pro Gly Pro Ala
420 425 430
<210> 164
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 164
ggtgaagctg gtccaccagg tgaagctggt gaagctggtg ctccaggtcc agaaggtgct 60
gctggtgaac caggtccaga aggtgaagaa ggtgaagctg gtgctccagg tgaagaaggt 120
ccaccaggtg aagctggtcc agctggtcca ccaggtgctg ctggtccagc tggtgctgaa 180
ggtgaagaag gtgaaccagg tgaaccaggt ccagctggtg ctgaaggtcc accaggtgct 240
gctggtccag ctggtccaga aggtccagaa ggtgctgctg gtgctgaagg tgaagaaggt 300
gaagctggtc caccaggtcc agctggtgaa gctggtccac caggtgaagc tggtgaagct 360
ggtgctccag gtccagaagg tgctgctggt gaaccaggtc cagaaggtga agaaggtgaa 420
gctggtgctc caggtgaaga aggtccacca ggtgaagctg gtccagctgg tccaccaggt 480
gctgctggtc cagctggtgc tgaaggtgaa gaaggtgaac caggtgaacc aggtccagct 540
ggtgctgaag gtccaccagg tgctgctggt ccagctggtc cagaaggtcc agaaggtgct 600
gctggtgctg aaggtgaaga aggtgaagct ggtccaccag gtccagctgg tgaagctggt 660
ccaccaggtg aagctggtga agctggtgct ccaggtccag aaggtgctgc tggtgaacca 720
ggtccagaag gtgaagaagg tgaagctggt gctccaggtg aagaaggtcc accaggtgaa 780
gctggtccag ctggtccacc aggtgctgct ggtccagctg gtgctgaagg tgaagaaggt 840
gaaccaggtg aaccaggtcc agctggtgct gaaggtccac caggtgctgc tggtccagct 900
ggtccagaag gtccagaagg tgctgctggt gctgaaggtg aagaaggtga agctggtcca 960
ccaggtccag ctggtgaagc tggtccacca ggtgaagctg gtgaagctgg tgctccaggt 1020
ccagaaggtg ctgctggtga accaggtcca gaaggtgaag aaggtgaagc tggtgctcca 1080
ggtgaagaag gtccaccagg tgaagctggt ccagctggtc caccaggtgc tgctggtcca 1140
gctggtgctg aaggtgaaga aggtgaacca ggtgaaccag gtccagctgg tgctgaaggt 1200
ccaccaggtg ctgctggtcc agctggtcca gaaggtccag aaggtgctgc tggtgctgaa 1260
ggtgaagaag gtgaagctgg tccaccaggt ccagct 1296
<210> 165
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 165
Gly Ala Glu Gly Pro Ala Gly Pro Glu Gly Ala Ala Gly Ala Pro Gly
1 5 10 15
Ala Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Glu
20 25 30
Ala Gly Pro Glu Gly Ala Pro Gly Ala Ala Gly Pro Ala Gly Ala Pro
35 40 45
Gly Ala Glu Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly Ala Ala Gly
50 55 60
Glu Pro Gly Pro Ala Gly Pro Ala Gly Ala Ala Gly Pro Pro Gly Pro
65 70 75 80
Ala Gly Glu Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Ala
85 90 95
Gly Ala Pro Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly Ala Glu Gly
100 105 110
Pro Ala Gly Pro Glu Gly Ala Ala Gly Ala Pro Gly Ala Ala Gly Pro
115 120 125
Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Glu Ala Gly Pro Glu
130 135 140
Gly Ala Pro Gly Ala Ala Gly Pro Ala Gly Ala Pro Gly Ala Glu Gly
145 150 155 160
Ala Ala Gly Ala Pro Gly Ala Glu Gly Ala Ala Gly Glu Pro Gly Pro
165 170 175
Ala Gly Pro Ala Gly Ala Ala Gly Pro Pro Gly Pro Ala Gly Glu Pro
180 185 190
Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Ala Gly Ala Pro Gly
195 200 205
Ala Glu Gly Pro Pro Gly Ala Ala Gly Ala Glu Gly Pro Ala Gly Pro
210 215 220
Glu Gly Ala Ala Gly Ala Pro Gly Ala Ala Gly Pro Pro Gly Ala Glu
225 230 235 240
Gly Ala Pro Gly Pro Ala Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly
245 250 255
Ala Ala Gly Pro Ala Gly Ala Pro Gly Ala Glu Gly Ala Ala Gly Ala
260 265 270
Pro Gly Ala Glu Gly Ala Ala Gly Glu Pro Gly Pro Ala Gly Pro Ala
275 280 285
Gly Ala Ala Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly
290 295 300
Ala Glu Gly Glu Pro Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly Pro
305 310 315 320
Pro Gly Ala Ala Gly Ala Glu Gly Pro Ala Gly Pro Glu Gly Ala Ala
325 330 335
Gly Ala Pro Gly Ala Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly
340 345 350
Pro Ala Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Ala Ala Gly Pro
355 360 365
Ala Gly Ala Pro Gly Ala Glu Gly Ala Ala Gly Ala Pro Gly Ala Glu
370 375 380
Gly Ala Ala Gly Glu Pro Gly Pro Ala Gly Pro Ala Gly Ala Ala Gly
385 390 395 400
Pro Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Ala Glu Gly Glu
405 410 415
Pro Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly Pro Pro Gly Ala Ala
420 425 430
<210> 166
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 166
ggtgctgaag gtccagctgg tccagaaggt gctgctggtg ctccaggtgc tgctggtcca 60
ccaggtgctg aaggtgctcc aggtccagct ggtgaagctg gtccagaagg tgctccaggt 120
gctgctggtc cagctggtgc tccaggtgct gaaggtgctg ctggtgctcc aggtgctgaa 180
ggtgctgctg gtgaaccagg tccagctggt ccagctggtg ctgctggtcc accaggtcca 240
gctggtgaac caggtgctcc aggtgctgaa ggtgaaccag gtgctgctgg tgctccaggt 300
gctgaaggtc caccaggtgc tgctggtgct gaaggtccag ctggtccaga aggtgctgct 360
ggtgctccag gtgctgctgg tccaccaggt gctgaaggtg ctccaggtcc agctggtgaa 420
gctggtccag aaggtgctcc aggtgctgct ggtccagctg gtgctccagg tgctgaaggt 480
gctgctggtg ctccaggtgc tgaaggtgct gctggtgaac caggtccagc tggtccagct 540
ggtgctgctg gtccaccagg tccagctggt gaaccaggtg ctccaggtgc tgaaggtgaa 600
ccaggtgctg ctggtgctcc aggtgctgaa ggtccaccag gtgctgctgg tgctgaaggt 660
ccagctggtc cagaaggtgc tgctggtgct ccaggtgctg ctggtccacc aggtgctgaa 720
ggtgctccag gtccagctgg tgaagctggt ccagaaggtg ctccaggtgc tgctggtcca 780
gctggtgctc caggtgctga aggtgctgct ggtgctccag gtgctgaagg tgctgctggt 840
gaaccaggtc cagctggtcc agctggtgct gctggtccac caggtccagc tggtgaacca 900
ggtgctccag gtgctgaagg tgaaccaggt gctgctggtg ctccaggtgc tgaaggtcca 960
ccaggtgctg ctggtgctga aggtccagct ggtccagaag gtgctgctgg tgctccaggt 1020
gctgctggtc caccaggtgc tgaaggtgct ccaggtccag ctggtgaagc tggtccagaa 1080
ggtgctccag gtgctgctgg tccagctggt gctccaggtg ctgaaggtgc tgctggtgct 1140
ccaggtgctg aaggtgctgc tggtgaacca ggtccagctg gtccagctgg tgctgctggt 1200
ccaccaggtc cagctggtga accaggtgct ccaggtgctg aaggtgaacc aggtgctgct 1260
ggtgctccag gtgctgaagg tccaccaggt gctgct 1296
<210> 167
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 167
Gly Ala Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly
1 5 10 15
Pro Pro Gly Glu Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly Glu
20 25 30
Pro Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Glu Ala Gly Ala Glu
35 40 45
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Ala Gly Pro Pro Gly Glu Glu Gly Pro Glu Gly Ala Pro Gly Ala
65 70 75 80
Glu Gly Pro Pro Gly Ala Ala Gly Glu Glu Gly Pro Ala Gly Ala Pro
85 90 95
Gly Glu Pro Gly Ala Ala Gly Glu Glu Gly Pro Glu Gly Ala Glu Gly
100 105 110
Pro Pro Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly Pro Pro Gly Glu
115 120 125
Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Ala Glu
130 135 140
Gly Pro Ala Gly Pro Ala Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly
145 150 155 160
Pro Pro Gly Glu Ala Gly Ala Pro Gly Glu Ala Gly Pro Ala Gly Pro
165 170 175
Pro Gly Glu Glu Gly Pro Glu Gly Ala Pro Gly Ala Glu Gly Pro Pro
180 185 190
Gly Ala Ala Gly Glu Glu Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly
195 200 205
Ala Ala Gly Glu Glu Gly Pro Glu Gly Ala Glu Gly Pro Pro Gly Pro
210 215 220
Glu Gly Ala Glu Gly Pro Ala Gly Pro Pro Gly Glu Glu Gly Ala Ala
225 230 235 240
Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Ala Glu Gly Pro Ala Gly
245 250 255
Pro Ala Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Pro Gly Glu
260 265 270
Ala Gly Ala Pro Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly Glu Glu
275 280 285
Gly Pro Glu Gly Ala Pro Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly
290 295 300
Glu Glu Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Ala Ala Gly Glu
305 310 315 320
Glu Gly Pro Glu Gly Ala Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu
325 330 335
Gly Pro Ala Gly Pro Pro Gly Glu Glu Gly Ala Ala Gly Ala Glu Gly
340 345 350
Glu Glu Gly Glu Pro Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Glu
355 360 365
Ala Gly Ala Glu Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro
370 375 380
Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly Glu Glu Gly Pro Glu Gly
385 390 395 400
Ala Pro Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly Glu Glu Gly Pro
405 410 415
Ala Gly Ala Pro Gly Glu Pro Gly Ala Ala Gly Glu Glu Gly Pro Glu
420 425 430
<210> 168
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 168
ggtgctgaag gtccaccagg tccagaaggt gctgaaggtc cagctggtcc accaggtgaa 60
gaaggtgctg ctggtgctga aggtgaagaa ggtgaaccag gtgctgaagg tccagctggt 120
ccagctggtg aagctggtgc tgaaggtgct ccaggtccac caggtgaagc tggtgctcca 180
ggtgaagctg gtccagctgg tccaccaggt gaagaaggtc cagaaggtgc tccaggtgct 240
gaaggtccac caggtgctgc tggtgaagaa ggtccagctg gtgctccagg tgaaccaggt 300
gctgctggtg aagaaggtcc agaaggtgct gaaggtccac caggtccaga aggtgctgaa 360
ggtccagctg gtccaccagg tgaagaaggt gctgctggtg ctgaaggtga agaaggtgaa 420
ccaggtgctg aaggtccagc tggtccagct ggtgaagctg gtgctgaagg tgctccaggt 480
ccaccaggtg aagctggtgc tccaggtgaa gctggtccag ctggtccacc aggtgaagaa 540
ggtccagaag gtgctccagg tgctgaaggt ccaccaggtg ctgctggtga agaaggtcca 600
gctggtgctc caggtgaacc aggtgctgct ggtgaagaag gtccagaagg tgctgaaggt 660
ccaccaggtc cagaaggtgc tgaaggtcca gctggtccac caggtgaaga aggtgctgct 720
ggtgctgaag gtgaagaagg tgaaccaggt gctgaaggtc cagctggtcc agctggtgaa 780
gctggtgctg aaggtgctcc aggtccacca ggtgaagctg gtgctccagg tgaagctggt 840
ccagctggtc caccaggtga agaaggtcca gaaggtgctc caggtgctga aggtccacca 900
ggtgctgctg gtgaagaagg tccagctggt gctccaggtg aaccaggtgc tgctggtgaa 960
gaaggtccag aaggtgctga aggtccacca ggtccagaag gtgctgaagg tccagctggt 1020
ccaccaggtg aagaaggtgc tgctggtgct gaaggtgaag aaggtgaacc aggtgctgaa 1080
ggtccagctg gtccagctgg tgaagctggt gctgaaggtg ctccaggtcc accaggtgaa 1140
gctggtgctc caggtgaagc tggtccagct ggtccaccag gtgaagaagg tccagaaggt 1200
gctccaggtg ctgaaggtcc accaggtgct gctggtgaag aaggtccagc tggtgctcca 1260
ggtgaaccag gtgctgctgg tgaagaaggt ccagaa 1296
<210> 169
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 169
Gly Ala Pro Gly Ala Pro Gly Ala Ala Gly Pro Glu Gly Pro Glu Gly
1 5 10 15
Glu Pro Gly Ala Ala Gly Ala Glu Gly Ala Glu Gly Ala Glu Gly Ala
20 25 30
Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Ala Pro Gly Ala Pro
35 40 45
Gly Ala Pro Gly Ala Ala Gly Ala Pro Gly Ala Ala Gly Glu Ala Gly
50 55 60
Ala Pro Gly Pro Glu Gly Glu Ala Gly Glu Ala Gly Glu Glu Gly Ala
65 70 75 80
Pro Gly Ala Ala Gly Glu Pro Gly Glu Glu Gly Glu Pro Gly Ala Ala
85 90 95
Gly Ala Pro Gly Ala Ala Gly Ala Glu Gly Pro Ala Gly Ala Pro Gly
100 105 110
Ala Pro Gly Ala Ala Gly Pro Glu Gly Pro Glu Gly Glu Pro Gly Ala
115 120 125
Ala Gly Ala Glu Gly Ala Glu Gly Ala Glu Gly Ala Ala Gly Ala Pro
130 135 140
Gly Pro Glu Gly Ala Glu Gly Ala Pro Gly Ala Pro Gly Ala Pro Gly
145 150 155 160
Ala Ala Gly Ala Pro Gly Ala Ala Gly Glu Ala Gly Ala Pro Gly Pro
165 170 175
Glu Gly Glu Ala Gly Glu Ala Gly Glu Glu Gly Ala Pro Gly Ala Ala
180 185 190
Gly Glu Pro Gly Glu Glu Gly Glu Pro Gly Ala Ala Gly Ala Pro Gly
195 200 205
Ala Ala Gly Ala Glu Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Ala
210 215 220
Ala Gly Pro Glu Gly Pro Glu Gly Glu Pro Gly Ala Ala Gly Ala Glu
225 230 235 240
Gly Ala Glu Gly Ala Glu Gly Ala Ala Gly Ala Pro Gly Pro Glu Gly
245 250 255
Ala Glu Gly Ala Pro Gly Ala Pro Gly Ala Pro Gly Ala Ala Gly Ala
260 265 270
Pro Gly Ala Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Glu Ala
275 280 285
Gly Glu Ala Gly Glu Glu Gly Ala Pro Gly Ala Ala Gly Glu Pro Gly
290 295 300
Glu Glu Gly Glu Pro Gly Ala Ala Gly Ala Pro Gly Ala Ala Gly Ala
305 310 315 320
Glu Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Ala Ala Gly Pro Glu
325 330 335
Gly Pro Glu Gly Glu Pro Gly Ala Ala Gly Ala Glu Gly Ala Glu Gly
340 345 350
Ala Glu Gly Ala Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Ala
355 360 365
Pro Gly Ala Pro Gly Ala Pro Gly Ala Ala Gly Ala Pro Gly Ala Ala
370 375 380
Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Glu Ala Gly Glu Ala Gly
385 390 395 400
Glu Glu Gly Ala Pro Gly Ala Ala Gly Glu Pro Gly Glu Glu Gly Glu
405 410 415
Pro Gly Ala Ala Gly Ala Pro Gly Ala Ala Gly Ala Glu Gly Pro Ala
420 425 430
<210> 170
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 170
ggtgctccag gtgctccagg tgctgctggt ccagaaggtc cagaaggtga accaggtgct 60
gctggtgctg aaggtgctga aggtgctgaa ggtgctgctg gtgctccagg tccagaaggt 120
gctgaaggtg ctccaggtgc tccaggtgct ccaggtgctg ctggtgctcc aggtgctgct 180
ggtgaagctg gtgctccagg tccagaaggt gaagctggtg aagctggtga agaaggtgct 240
ccaggtgctg ctggtgaacc aggtgaagaa ggtgaaccag gtgctgctgg tgctccaggt 300
gctgctggtg ctgaaggtcc agctggtgct ccaggtgctc caggtgctgc tggtccagaa 360
ggtccagaag gtgaaccagg tgctgctggt gctgaaggtg ctgaaggtgc tgaaggtgct 420
gctggtgctc caggtccaga aggtgctgaa ggtgctccag gtgctccagg tgctccaggt 480
gctgctggtg ctccaggtgc tgctggtgaa gctggtgctc caggtccaga aggtgaagct 540
ggtgaagctg gtgaagaagg tgctccaggt gctgctggtg aaccaggtga agaaggtgaa 600
ccaggtgctg ctggtgctcc aggtgctgct ggtgctgaag gtccagctgg tgctccaggt 660
gctccaggtg ctgctggtcc agaaggtcca gaaggtgaac caggtgctgc tggtgctgaa 720
ggtgctgaag gtgctgaagg tgctgctggt gctccaggtc cagaaggtgc tgaaggtgct 780
ccaggtgctc caggtgctcc aggtgctgct ggtgctccag gtgctgctgg tgaagctggt 840
gctccaggtc cagaaggtga agctggtgaa gctggtgaag aaggtgctcc aggtgctgct 900
ggtgaaccag gtgaagaagg tgaaccaggt gctgctggtg ctccaggtgc tgctggtgct 960
gaaggtccag ctggtgctcc aggtgctcca ggtgctgctg gtccagaagg tccagaaggt 1020
gaaccaggtg ctgctggtgc tgaaggtgct gaaggtgctg aaggtgctgc tggtgctcca 1080
ggtccagaag gtgctgaagg tgctccaggt gctccaggtg ctccaggtgc tgctggtgct 1140
ccaggtgctg ctggtgaagc tggtgctcca ggtccagaag gtgaagctgg tgaagctggt 1200
gaagaaggtg ctccaggtgc tgctggtgaa ccaggtgaag aaggtgaacc aggtgctgct 1260
ggtgctccag gtgctgctgg tgctgaaggt ccagct 1296
<210> 171
<211> 459
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 171
Gly Pro Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly
1 5 10 15
Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala
20 25 30
Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala
35 40 45
Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly
50 55 60
Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu
65 70 75 80
Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala
85 90 95
Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly
100 105 110
Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro
115 120 125
Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala
130 135 140
Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly
145 150 155 160
Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu
165 170 175
Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro
180 185 190
Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly
195 200 205
Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro
210 215 220
Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala
225 230 235 240
Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly
245 250 255
Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala
260 265 270
Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro
275 280 285
Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly
290 295 300
Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala
305 310 315 320
Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro
325 330 335
Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly
340 345 350
Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro
355 360 365
Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro
370 375 380
Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly
385 390 395 400
Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu
405 410 415
Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala
420 425 430
Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly
435 440 445
Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala
450 455
<210> 172
<211> 1377
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 172
ggtccacctg gtgctccagg tgaaccaggt ccagctggtc caccaggtgc tgaaggtgct 60
ccaggtccag ctggtccaga aggtgaagct ggtgctgaag gtgaaccagg tgaagctggt 120
ccaccaggtg ctccaggtga agctggtgct gaaggtgctc caggtccaga aggtgaacca 180
ggtgaagctg gtccagaagg tgctccaggt ccagctggtg aaccaggtgc tccaggtgaa 240
gctggtgaac caggtccacc aggtccagct ggtgctccag gtccagctgg tgaaccaggt 300
gaagctggtc caccaggtgc tccaggtcca gctggtccac caggtccagc tggtgctcca 360
ggtgaaccag gtccagctgg tccaccaggt gctgaaggtg ctccaggtcc agctggtcca 420
gaaggtgaag ctggtgctga aggtgaacca ggtgaagctg gtccaccagg tgctccaggt 480
gaagctggtg ctgaaggtgc tccaggtcca gaaggtgaac caggtgaagc tggtccagaa 540
ggtgctccag gtccagctgg tgaaccaggt gctccaggtg aagctggtga accaggtcca 600
ccaggtccag ctggtgctcc aggtccagct ggtgaaccag gtgaagctgg tccaccaggt 660
gctccaggtc cagctggtcc accaggtcca gctggtgctc caggtgaacc aggtccagct 720
ggtccaccag gtgctgaagg tgctccaggt ccagctggtc cagaaggtga agctggtgct 780
gaaggtgaac caggtgaagc tggtccacca ggtgctccag gtgaagctgg tgctgaaggt 840
gctccaggtc cagaaggtga accaggtgaa gctggtccag aaggtgctcc aggtccagct 900
ggtgaaccag gtgctccagg tgaagctggt gaaccaggtc caccaggtcc agctggtgct 960
ccaggtccag ctggtgaacc aggtgaagct ggtccaccag gtgctccagg tccagctggt 1020
ccaccaggtc cagctggtgc tccaggtgaa ccaggtccag ctggtccacc aggtgctgaa 1080
ggtgctccag gtccagctgg tccagaaggt gaagctggtg ctgaaggtga accaggtgaa 1140
gctggtccac caggtgctcc aggtgaagct ggtgctgaag gtgctccagg tccagaaggt 1200
gaaccaggtg aagctggtcc agaaggtgct ccaggtccag ctggtgaacc aggtgctcca 1260
ggtgaagctg gtgaaccagg tccaccaggt ccagctggtg ctccaggtcc agctggtgaa 1320
ccaggtgaag ctggtccacc aggtgctcca ggtccagctg gtccaccagg tccagct 1377
<210> 173
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 173
Gly Pro Pro Gly Ala Ala Gly Ala Glu Gly Pro Ala Gly Ala Pro Gly
1 5 10 15
Ala Ala Gly Ala Ala Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Glu
20 25 30
Pro Gly Ala Ala Gly Glu Pro Gly Ala Ala Gly Pro Pro Gly Ala Ala
35 40 45
Gly Ala Glu Gly Pro Ala Gly Ala Ala Gly Pro Ala Gly Ala Ala Gly
50 55 60
Ala Pro Gly Ala Ala Gly Glu Ala Gly Ala Pro Gly Glu Ala Gly Ala
65 70 75 80
Pro Gly Ala Glu Gly Pro Ala Gly Pro Glu Gly Ala Pro Gly Ala Glu
85 90 95
Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly Ala Ala Gly Pro Pro Gly
100 105 110
Ala Ala Gly Ala Glu Gly Pro Ala Gly Ala Pro Gly Ala Ala Gly Ala
115 120 125
Ala Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Glu Pro Gly Ala Ala
130 135 140
Gly Glu Pro Gly Ala Ala Gly Pro Pro Gly Ala Ala Gly Ala Glu Gly
145 150 155 160
Pro Ala Gly Ala Ala Gly Pro Ala Gly Ala Ala Gly Ala Pro Gly Ala
165 170 175
Ala Gly Glu Ala Gly Ala Pro Gly Glu Ala Gly Ala Pro Gly Ala Glu
180 185 190
Gly Pro Ala Gly Pro Glu Gly Ala Pro Gly Ala Glu Gly Ala Ala Gly
195 200 205
Ala Pro Gly Ala Glu Gly Ala Ala Gly Pro Pro Gly Ala Ala Gly Ala
210 215 220
Glu Gly Pro Ala Gly Ala Pro Gly Ala Ala Gly Ala Ala Gly Glu Ala
225 230 235 240
Gly Pro Glu Gly Ala Pro Gly Glu Pro Gly Ala Ala Gly Glu Pro Gly
245 250 255
Ala Ala Gly Pro Pro Gly Ala Ala Gly Ala Glu Gly Pro Ala Gly Ala
260 265 270
Ala Gly Pro Ala Gly Ala Ala Gly Ala Pro Gly Ala Ala Gly Glu Ala
275 280 285
Gly Ala Pro Gly Glu Ala Gly Ala Pro Gly Ala Glu Gly Pro Ala Gly
290 295 300
Pro Glu Gly Ala Pro Gly Ala Glu Gly Ala Ala Gly Ala Pro Gly Ala
305 310 315 320
Glu Gly Ala Ala Gly Pro Pro Gly Ala Ala Gly Ala Glu Gly Pro Ala
325 330 335
Gly Ala Pro Gly Ala Ala Gly Ala Ala Gly Glu Ala Gly Pro Glu Gly
340 345 350
Ala Pro Gly Glu Pro Gly Ala Ala Gly Glu Pro Gly Ala Ala Gly Pro
355 360 365
Pro Gly Ala Ala Gly Ala Glu Gly Pro Ala Gly Ala Ala Gly Pro Ala
370 375 380
Gly Ala Ala Gly Ala Pro Gly Ala Ala Gly Glu Ala Gly Ala Pro Gly
385 390 395 400
Glu Ala Gly Ala Pro Gly Ala Glu Gly Pro Ala Gly Pro Glu Gly Ala
405 410 415
Pro Gly Ala Glu Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly Ala Ala
420 425 430
<210> 174
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 174
ggtccaccag gtgctgctgg tgctgaaggt ccagctggtg ctccaggtgc tgctggtgct 60
gctggtgaag ctggtccaga aggtgctcca ggtgaaccag gtgctgctgg tgaaccaggt 120
gctgctggtc caccaggtgc tgctggtgct gaaggtccag ctggtgctgc tggtccagct 180
ggtgctgctg gtgctccagg tgctgctggt gaagctggtg ctccaggtga agctggtgct 240
ccaggtgctg aaggtccagc tggtccagaa ggtgctccag gtgctgaagg tgctgctggt 300
gctccaggtg ctgaaggtgc tgctggtcca ccaggtgctg ctggtgctga aggtccagct 360
ggtgctccag gtgctgctgg tgctgctggt gaagctggtc cagaaggtgc tccaggtgaa 420
ccaggtgctg ctggtgaacc aggtgctgct ggtccaccag gtgctgctgg tgctgaaggt 480
ccagctggtg ctgctggtcc agctggtgct gctggtgctc caggtgctgc tggtgaagct 540
ggtgctccag gtgaagctgg tgctccaggt gctgaaggtc cagctggtcc agaaggtgct 600
ccaggtgctg aaggtgctgc tggtgctcca ggtgctgaag gtgctgctgg tccaccaggt 660
gctgctggtg ctgaaggtcc agctggtgct ccaggtgctg ctggtgctgc tggtgaagct 720
ggtccagaag gtgctccagg tgaaccaggt gctgctggtg aaccaggtgc tgctggtcca 780
ccaggtgctg ctggtgctga aggtccagct ggtgctgctg gtccagctgg tgctgctggt 840
gctccaggtg ctgctggtga agctggtgct ccaggtgaag ctggtgctcc aggtgctgaa 900
ggtccagctg gtccagaagg tgctccaggt gctgaaggtg ctgctggtgc tccaggtgct 960
gaaggtgctg ctggtccacc aggtgctgct ggtgctgaag gtccagctgg tgctccaggt 1020
gctgctggtg ctgctggtga agctggtcca gaaggtgctc caggtgaacc aggtgctgct 1080
ggtgaaccag gtgctgctgg tccaccaggt gctgctggtg ctgaaggtcc agctggtgct 1140
gctggtccag ctggtgctgc tggtgctcca ggtgctgctg gtgaagctgg tgctccaggt 1200
gaagctggtg ctccaggtgc tgaaggtcca gctggtccag aaggtgctcc aggtgctgaa 1260
ggtgctgctg gtgctccagg tgctgaaggt gctgct 1296
<210> 175
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 175
Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Glu Ala Gly Pro Glu Gly
1 5 10 15
Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Glu
20 25 30
Ala Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly Glu Ala Gly Ala Ala
35 40 45
Gly Ala Glu Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly
50 55 60
Ala Pro Gly Ala Ala Gly Ala Pro Gly Ala Pro Gly Ala Ala Gly Pro
65 70 75 80
Ala Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Ala Gly Ala Glu Gly Ala Pro Gly Glu Pro Gly
100 105 110
Pro Glu Gly Ala Ala Gly Glu Ala Gly Pro Glu Gly Ala Glu Gly Pro
115 120 125
Ala Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Glu Ala Gly Ala Ala
130 135 140
Gly Ala Pro Gly Ala Glu Gly Glu Ala Gly Ala Ala Gly Ala Glu Gly
145 150 155 160
Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala
165 170 175
Ala Gly Ala Pro Gly Ala Pro Gly Ala Ala Gly Pro Ala Gly Glu Pro
180 185 190
Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly
195 200 205
Ala Ala Gly Ala Glu Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Ala
210 215 220
Ala Gly Glu Ala Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly Pro Ala
225 230 235 240
Gly Ala Pro Gly Ala Pro Gly Glu Ala Gly Ala Ala Gly Ala Pro Gly
245 250 255
Ala Glu Gly Glu Ala Gly Ala Ala Gly Ala Glu Gly Pro Ala Gly Glu
260 265 270
Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Ala Gly Ala Pro
275 280 285
Gly Ala Pro Gly Ala Ala Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly
290 295 300
Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Ala Gly Ala
305 310 315 320
Glu Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Glu Ala
325 330 335
Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro Gly
340 345 350
Ala Pro Gly Glu Ala Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly Glu
355 360 365
Ala Gly Ala Ala Gly Ala Glu Gly Pro Ala Gly Glu Ala Gly Ala Pro
370 375 380
Gly Pro Pro Gly Ala Pro Gly Ala Ala Gly Ala Pro Gly Ala Pro Gly
385 390 395 400
Ala Ala Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu
405 410 415
Ala Gly Ala Pro Gly Pro Pro Gly Ala Ala Gly Ala Glu Gly Ala Pro
420 425 430
<210> 176
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 176
ggtgaaccag gtccagaagg tgctgctggt gaagctggtc cagaaggtgc tgaaggtcca 60
gctggtccag ctggtgctcc aggtgctcca ggtgaagctg gtgctgctgg tgctccaggt 120
gctgaaggtg aagctggtgc tgctggtgct gaaggtccag ctggtgaagc tggtgctcca 180
ggtccaccag gtgctccagg tgctgctggt gctccaggtg ctccaggtgc tgctggtcca 240
gctggtgaac caggtccaga aggtccacca ggtgaagctg gtgctccagg tccaccaggt 300
gctgctggtg ctgaaggtgc tccaggtgaa ccaggtccag aaggtgctgc tggtgaagct 360
ggtccagaag gtgctgaagg tccagctggt ccagctggtg ctccaggtgc tccaggtgaa 420
gctggtgctg ctggtgctcc aggtgctgaa ggtgaagctg gtgctgctgg tgctgaaggt 480
ccagctggtg aagctggtgc tccaggtcca ccaggtgctc caggtgctgc tggtgctcca 540
ggtgctccag gtgctgctgg tccagctggt gaaccaggtc cagaaggtcc accaggtgaa 600
gctggtgctc caggtccacc aggtgctgct ggtgctgaag gtgctccagg tgaaccaggt 660
ccagaaggtg ctgctggtga agctggtcca gaaggtgctg aaggtccagc tggtccagct 720
ggtgctccag gtgctccagg tgaagctggt gctgctggtg ctccaggtgc tgaaggtgaa 780
gctggtgctg ctggtgctga aggtccagct ggtgaagctg gtgctccagg tccaccaggt 840
gctccaggtg ctgctggtgc tccaggtgct ccaggtgctg ctggtccagc tggtgaacca 900
ggtccagaag gtccaccagg tgaagctggt gctccaggtc caccaggtgc tgctggtgct 960
gaaggtgctc caggtgaacc aggtccagaa ggtgctgctg gtgaagctgg tccagaaggt 1020
gctgaaggtc cagctggtcc agctggtgct ccaggtgctc caggtgaagc tggtgctgct 1080
ggtgctccag gtgctgaagg tgaagctggt gctgctggtg ctgaaggtcc agctggtgaa 1140
gctggtgctc caggtccacc aggtgctcca ggtgctgctg gtgctccagg tgctccaggt 1200
gctgctggtc cagctggtga accaggtcca gaaggtccac caggtgaagc tggtgctcca 1260
ggtccaccag gtgctgctgg tgctgaaggt gctcca 1296
<210> 177
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 177
Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly
1 5 10 15
Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Glu
20 25 30
Pro Gly Ala Ala Gly Glu Pro Gly Ala Ala Gly Pro Pro Gly Ala Glu
35 40 45
Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
50 55 60
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
65 70 75 80
Ala Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Ala Ala Gly Pro Glu
85 90 95
Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro Gly Pro Glu Gly
100 105 110
Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala
115 120 125
Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Glu Pro Gly Ala Ala
130 135 140
Gly Glu Pro Gly Ala Ala Gly Pro Pro Gly Ala Glu Gly Ala Glu Gly
145 150 155 160
Pro Ala Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro
165 170 175
Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Glu Pro
180 185 190
Gly Pro Glu Gly Ala Ala Gly Ala Ala Gly Pro Glu Gly Ala Glu Gly
195 200 205
Pro Ala Gly Pro Ala Gly Ala Pro Gly Pro Glu Gly Ala Pro Gly Pro
210 215 220
Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro
225 230 235 240
Gly Glu Ala Gly Ala Pro Gly Glu Pro Gly Ala Ala Gly Glu Pro Gly
245 250 255
Ala Ala Gly Pro Pro Gly Ala Glu Gly Ala Glu Gly Pro Ala Gly Pro
260 265 270
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
275 280 285
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Glu Gly
290 295 300
Ala Ala Gly Ala Ala Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly Pro
305 310 315 320
Ala Gly Ala Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala
325 330 335
Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly
340 345 350
Ala Pro Gly Glu Pro Gly Ala Ala Gly Glu Pro Gly Ala Ala Gly Pro
355 360 365
Pro Gly Ala Glu Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Glu Pro
370 375 380
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly
385 390 395 400
Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Ala
405 410 415
Ala Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro
420 425 430
<210> 178
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 178
ggtccagaag gtgctccagg tccaccaggt ccagctggtg aaccaggtcc agctggtgct 60
ccaggtccac caggtgaagc tggtgctcca ggtgaaccag gtgctgctgg tgaaccaggt 120
gctgctggtc caccaggtgc tgaaggtgct gaaggtccag ctggtccagc tggtgaacca 180
ggtccagctg gtgctccagg tccaccaggt gaagctggtc cagctggtgc tccaggtgaa 240
gctggtgaac caggtccaga aggtgctgct ggtgctgctg gtccagaagg tgctgaaggt 300
ccagctggtc cagctggtgc tccaggtcca gaaggtgctc caggtccacc aggtccagct 360
ggtgaaccag gtccagctgg tgctccaggt ccaccaggtg aagctggtgc tccaggtgaa 420
ccaggtgctg ctggtgaacc aggtgctgct ggtccaccag gtgctgaagg tgctgaaggt 480
ccagctggtc cagctggtga accaggtcca gctggtgctc caggtccacc aggtgaagct 540
ggtccagctg gtgctccagg tgaagctggt gaaccaggtc cagaaggtgc tgctggtgct 600
gctggtccag aaggtgctga aggtccagct ggtccagctg gtgctccagg tccagaaggt 660
gctccaggtc caccaggtcc agctggtgaa ccaggtccag ctggtgctcc aggtccacca 720
ggtgaagctg gtgctccagg tgaaccaggt gctgctggtg aaccaggtgc tgctggtcca 780
ccaggtgctg aaggtgctga aggtccagct ggtccagctg gtgaaccagg tccagctggt 840
gctccaggtc caccaggtga agctggtcca gctggtgctc caggtgaagc tggtgaacca 900
ggtccagaag gtgctgctgg tgctgctggt ccagaaggtg ctgaaggtcc agctggtcca 960
gctggtgctc caggtccaga aggtgctcca ggtccaccag gtccagctgg tgaaccaggt 1020
ccagctggtg ctccaggtcc accaggtgaa gctggtgctc caggtgaacc aggtgctgct 1080
ggtgaaccag gtgctgctgg tccaccaggt gctgaaggtg ctgaaggtcc agctggtcca 1140
gctggtgaac caggtccagc tggtgctcca ggtccaccag gtgaagctgg tccagctggt 1200
gctccaggtg aagctggtga accaggtcca gaaggtgctg ctggtgctgc tggtccagaa 1260
ggtgctgaag gtccagctgg tccagctggt gctcca 1296
<210> 179
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 179
Gly Ala Ala Gly Ala Pro Gly Ala Ala Gly Ala Ala Gly Ala Pro Gly
1 5 10 15
Pro Ala Gly Ala Ala Gly Ala Pro Gly Glu Ala Gly Pro Ala Gly Ala
20 25 30
Pro Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly Ala Ala Gly Ala Pro
35 40 45
Gly Ala Glu Gly Ala Pro Gly Glu Ala Gly Ala Ala Gly Glu Ala Gly
50 55 60
Ala Pro Gly Pro Ala Gly Ala Pro Gly Pro Glu Gly Ala Pro Gly Ala
65 70 75 80
Pro Gly Ala Pro Gly Ala Pro Gly Pro Ala Gly Ala Pro Gly Ala Pro
85 90 95
Gly Ala Pro Gly Pro Ala Gly Ala Glu Gly Ala Pro Gly Ala Ala Gly
100 105 110
Ala Pro Gly Ala Ala Gly Ala Ala Gly Ala Pro Gly Pro Ala Gly Ala
115 120 125
Ala Gly Ala Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Ala Ala
130 135 140
Gly Ala Pro Gly Ala Glu Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly
145 150 155 160
Ala Pro Gly Glu Ala Gly Ala Ala Gly Glu Ala Gly Ala Pro Gly Pro
165 170 175
Ala Gly Ala Pro Gly Pro Glu Gly Ala Pro Gly Ala Pro Gly Ala Pro
180 185 190
Gly Ala Pro Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Ala Pro Gly
195 200 205
Pro Ala Gly Ala Glu Gly Ala Pro Gly Ala Ala Gly Ala Pro Gly Ala
210 215 220
Ala Gly Ala Ala Gly Ala Pro Gly Pro Ala Gly Ala Ala Gly Ala Pro
225 230 235 240
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Ala Ala Gly Ala Pro Gly
245 250 255
Ala Glu Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly Ala Pro Gly Glu
260 265 270
Ala Gly Ala Ala Gly Glu Ala Gly Ala Pro Gly Pro Ala Gly Ala Pro
275 280 285
Gly Pro Glu Gly Ala Pro Gly Ala Pro Gly Ala Pro Gly Ala Pro Gly
290 295 300
Pro Ala Gly Ala Pro Gly Ala Pro Gly Ala Pro Gly Pro Ala Gly Ala
305 310 315 320
Glu Gly Ala Pro Gly Ala Ala Gly Ala Pro Gly Ala Ala Gly Ala Ala
325 330 335
Gly Ala Pro Gly Pro Ala Gly Ala Ala Gly Ala Pro Gly Glu Ala Gly
340 345 350
Pro Ala Gly Ala Pro Gly Ala Ala Gly Ala Pro Gly Ala Glu Gly Ala
355 360 365
Ala Gly Ala Pro Gly Ala Glu Gly Ala Pro Gly Glu Ala Gly Ala Ala
370 375 380
Gly Glu Ala Gly Ala Pro Gly Pro Ala Gly Ala Pro Gly Pro Glu Gly
385 390 395 400
Ala Pro Gly Ala Pro Gly Ala Pro Gly Ala Pro Gly Pro Ala Gly Ala
405 410 415
Pro Gly Ala Pro Gly Ala Pro Gly Pro Ala Gly Ala Glu Gly Ala Pro
420 425 430
<210> 180
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 180
ggtgctgctg gtgctccagg tgctgctggt gctgctggtg ctccaggtcc agctggtgct 60
gctggtgctc caggtgaagc tggtccagct ggtgctccag gtgctgctgg tgctccaggt 120
gctgaaggtg ctgctggtgc tccaggtgct gaaggtgctc caggtgaagc tggtgctgct 180
ggtgaagctg gtgctccagg tccagctggt gctccaggtc cagaaggtgc tccaggtgct 240
ccaggtgctc caggtgctcc aggtccagct ggtgctccag gtgctccagg tgctccaggt 300
ccagctggtg ctgaaggtgc tccaggtgct gctggtgctc caggtgctgc tggtgctgct 360
ggtgctccag gtccagctgg tgctgctggt gctccaggtg aagctggtcc agctggtgct 420
ccaggtgctg ctggtgctcc aggtgctgaa ggtgctgctg gtgctccagg tgctgaaggt 480
gctccaggtg aagctggtgc tgctggtgaa gctggtgctc caggtccagc tggtgctcca 540
ggtccagaag gtgctccagg tgctccaggt gctccaggtg ctccaggtcc agctggtgct 600
ccaggtgctc caggtgctcc aggtccagct ggtgctgaag gtgctccagg tgctgctggt 660
gctccaggtg ctgctggtgc tgctggtgct ccaggtccag ctggtgctgc tggtgctcca 720
ggtgaagctg gtccagctgg tgctccaggt gctgctggtg ctccaggtgc tgaaggtgct 780
gctggtgctc caggtgctga aggtgctcca ggtgaagctg gtgctgctgg tgaagctggt 840
gctccaggtc cagctggtgc tccaggtcca gaaggtgctc caggtgctcc aggtgctcca 900
ggtgctccag gtccagctgg tgctccaggt gctccaggtg ctccaggtcc agctggtgct 960
gaaggtgctc caggtgctgc tggtgctcca ggtgctgctg gtgctgctgg tgctccaggt 1020
ccagctggtg ctgctggtgc tccaggtgaa gctggtccag ctggtgctcc aggtgctgct 1080
ggtgctccag gtgctgaagg tgctgctggt gctccaggtg ctgaaggtgc tccaggtgaa 1140
gctggtgctg ctggtgaagc tggtgctcca ggtccagctg gtgctccagg tccagaaggt 1200
gctccaggtg ctccaggtgc tccaggtgct ccaggtccag ctggtgctcc aggtgctcca 1260
ggtgctccag gtccagctgg tgctgaaggt gctcca 1296
<210> 181
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 181
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
1 5 10 15
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro
20 25 30
Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro
35 40 45
Gly Pro Glu Gly Pro Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala
85 90 95
Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
100 105 110
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
115 120 125
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro Ala Gly Ala Glu
130 135 140
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly
145 150 155 160
Pro Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala
165 170 175
Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Ala
180 185 190
Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly
195 200 205
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro
210 215 220
Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro
225 230 235 240
Gly Pro Glu Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
245 250 255
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu
260 265 270
Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro
275 280 285
Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly
290 295 300
Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro
305 310 315 320
Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu
325 330 335
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly
340 345 350
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
355 360 365
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Pro Gly Pro Glu
370 375 380
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly
385 390 395 400
Ala Glu Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro
405 410 415
Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro
420 425 430
<210> 182
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 182
ggtgaagctg gtccaccagg tccagctggt gctgaaggtg aagctggtcc agctggtgct 60
ccaggtgaac caggtccaga aggtccacca ggtccagctg gtgctgaagg tgaagctggt 120
ccagctggtg ctccaggtga accaggtcca gaaggtccac caggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag ctggtgctcc aggtgaagct ggtccaccag gtccagctgg tgctgaaggt 300
gaagctggtc cagctggtgc tccaggtgaa gctggtccac caggtccagc tggtgctgaa 360
ggtgaagctg gtccagctgg tgctccaggt gaaccaggtc cagaaggtcc accaggtcca 420
gctggtgctg aaggtgaagc tggtccagct ggtgctccag gtgaaccagg tccagaaggt 480
ccaccaggtg aaccaggtcc agaaggtcca ccaggtgaag ctggtgctcc aggtccacca 540
ggtgctccag gtgctgaagg tgaaccaggt ccagctggtg ctccaggtga agctggtcca 600
ccaggtccag ctggtgctga aggtgaagct ggtccagctg gtgctccagg tgaagctggt 660
ccaccaggtc cagctggtgc tgaaggtgaa gctggtccag ctggtgctcc aggtgaacca 720
ggtccagaag gtccaccagg tccagctggt gctgaaggtg aagctggtcc agctggtgct 780
ccaggtgaac caggtccaga aggtccacca ggtgaaccag gtccagaagg tccaccaggt 840
gaagctggtg ctccaggtcc accaggtgct ccaggtgctg aaggtgaacc aggtccagct 900
ggtgctccag gtgaagctgg tccaccaggt ccagctggtg ctgaaggtga agctggtcca 960
gctggtgctc caggtgaagc tggtccacca ggtccagctg gtgctgaagg tgaagctggt 1020
ccagctggtg ctccaggtga accaggtcca gaaggtccac caggtccagc tggtgctgaa 1080
ggtgaagctg gtccagctgg tgctccaggt gaaccaggtc cagaaggtcc accaggtgaa 1140
ccaggtccag aaggtccacc aggtgaagct ggtgctccag gtccaccagg tgctccaggt 1200
gctgaaggtg aaccaggtcc agctggtgct ccaggtgaag ctggtccacc aggtccagct 1260
ggtgctgaag gtgaagctgg tccagctggt gctcca 1296
<210> 183
<211> 459
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 183
Gly Pro Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly
1 5 10 15
Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala
20 25 30
Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala
35 40 45
Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly
50 55 60
Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Pro
65 70 75 80
Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Glu Pro Gly Ala Pro
85 90 95
Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly
100 105 110
Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro
115 120 125
Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala
130 135 140
Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly
145 150 155 160
Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu
165 170 175
Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro
180 185 190
Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Glu Pro Gly
195 200 205
Ala Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro
210 215 220
Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala
225 230 235 240
Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly
245 250 255
Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala
260 265 270
Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro
275 280 285
Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly
290 295 300
Ala Pro Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Glu
305 310 315 320
Pro Gly Ala Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Ala Pro
325 330 335
Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly
340 345 350
Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro
355 360 365
Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro
370 375 380
Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly
385 390 395 400
Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu
405 410 415
Pro Gly Ala Pro Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala
420 425 430
Gly Glu Pro Gly Ala Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly
435 440 445
Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala
450 455
<210> 184
<211> 1377
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 184
ggtccacctg gtgctccagg tgaaccaggt ccagctggtc caccaggtgc tgaaggtgct 60
ccaggtccag ctggtccaga aggtgaagct ggtgctgaag gtgaaccagg tgaagctggt 120
ccaccaggtg ctccaggtga agctggtgct gaaggtgctc caggtccaga aggtgaacca 180
ggtgaagctg gtccagaagg tgctccaggt ccagctggtg aaccaggtgc tccaggtcca 240
ccaggtgaac caggtccagc tggtgaagct ggtgaaccag gtgctccagg tccagctggt 300
gaagctggtc caccaggtgc tccaggtcca gctggtccac caggtccagc tggtgctcca 360
ggtgaaccag gtccagctgg tccaccaggt gctgaaggtg ctccaggtcc agctggtcca 420
gaaggtgaag ctggtgctga aggtgaacca ggtgaagctg gtccaccagg tgctccaggt 480
gaagctggtg ctgaaggtgc tccaggtcca gaaggtgaac caggtgaagc tggtccagaa 540
ggtgctccag gtccagctgg tgaaccaggt gctccaggtc caccaggtga accaggtcca 600
gctggtgaag ctggtgaacc aggtgctcca ggtccagctg gtgaagctgg tccaccaggt 660
gctccaggtc cagctggtcc accaggtcca gctggtgctc caggtgaacc aggtccagct 720
ggtccaccag gtgctgaagg tgctccaggt ccagctggtc cagaaggtga agctggtgct 780
gaaggtgaac caggtgaagc tggtccacca ggtgctccag gtgaagctgg tgctgaaggt 840
gctccaggtc cagaaggtga accaggtgaa gctggtccag aaggtgctcc aggtccagct 900
ggtgaaccag gtgctccagg tccaccaggt gaaccaggtc cagctggtga agctggtgaa 960
ccaggtgctc caggtccagc tggtgaagct ggtccaccag gtgctccagg tccagctggt 1020
ccaccaggtc cagctggtgc tccaggtgaa ccaggtccag ctggtccacc aggtgctgaa 1080
ggtgctccag gtccagctgg tccagaaggt gaagctggtg ctgaaggtga accaggtgaa 1140
gctggtccac caggtgctcc aggtgaagct ggtgctgaag gtgctccagg tccagaaggt 1200
gaaccaggtg aagctggtcc agaaggtgct ccaggtccag ctggtgaacc aggtgctcca 1260
ggtccaccag gtgaaccagg tccagctggt gaagctggtg aaccaggtgc tccaggtcca 1320
gctggtgaag ctggtccacc aggtgctcca ggtccagctg gtccaccagg tccagct 1377
<210> 185
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 185
Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly
1 5 10 15
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Glu Glu Gly Glu
20 25 30
Pro Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Glu Ala Gly Ala Glu
35 40 45
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Ala Pro Gly Ala Glu Gly Glu Glu Gly Pro Pro Gly Glu Ala
85 90 95
Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly Ala Ala Gly Pro Ala Gly
100 105 110
Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro
115 120 125
Ala Gly Ala Pro Gly Glu Ala Gly Glu Glu Gly Glu Pro Gly Ala Glu
130 135 140
Gly Pro Ala Gly Pro Ala Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly
145 150 155 160
Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro
165 170 175
Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Ala Pro
180 185 190
Gly Ala Glu Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly
195 200 205
Ala Pro Gly Pro Glu Gly Ala Ala Gly Pro Ala Gly Glu Pro Gly Pro
210 215 220
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro
225 230 235 240
Gly Glu Ala Gly Glu Glu Gly Glu Pro Gly Ala Glu Gly Pro Ala Gly
245 250 255
Pro Ala Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Pro Gly Pro
260 265 270
Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu
275 280 285
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Ala Glu Gly
290 295 300
Glu Glu Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro
305 310 315 320
Glu Gly Ala Ala Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
325 330 335
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
340 345 350
Glu Glu Gly Glu Pro Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Glu
355 360 365
Ala Gly Ala Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro
370 375 380
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
385 390 395 400
Pro Ala Gly Ala Pro Gly Ala Pro Gly Ala Glu Gly Glu Glu Gly Pro
405 410 415
Pro Gly Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly Ala Ala
420 425 430
<210> 186
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 186
ggtccagctg gtgaaccagg tccagctggt gctccaggtc caccaggtga agctggtcca 60
gctggtgctc caggtgaagc tggtgaagaa ggtgaaccag gtgctgaagg tccagctggt 120
ccagctggtg aagctggtgc tgaaggtgct ccaggtccac caggtccagc tggtgctcca 180
ggtgaagctg gtccaccagg tccagctggt gctgaaggtg aagctggtcc agctggtgct 240
ccaggtgctc caggtgctga aggtgaagaa ggtccaccag gtgaagctgg tgaaccaggt 300
gctccaggtc cagaaggtgc tgctggtcca gctggtgaac caggtccagc tggtgctcca 360
ggtccaccag gtgaagctgg tccagctggt gctccaggtg aagctggtga agaaggtgaa 420
ccaggtgctg aaggtccagc tggtccagct ggtgaagctg gtgctgaagg tgctccaggt 480
ccaccaggtc cagctggtgc tccaggtgaa gctggtccac caggtccagc tggtgctgaa 540
ggtgaagctg gtccagctgg tgctccaggt gctccaggtg ctgaaggtga agaaggtcca 600
ccaggtgaag ctggtgaacc aggtgctcca ggtccagaag gtgctgctgg tccagctggt 660
gaaccaggtc cagctggtgc tccaggtcca ccaggtgaag ctggtccagc tggtgctcca 720
ggtgaagctg gtgaagaagg tgaaccaggt gctgaaggtc cagctggtcc agctggtgaa 780
gctggtgctg aaggtgctcc aggtccacca ggtccagctg gtgctccagg tgaagctggt 840
ccaccaggtc cagctggtgc tgaaggtgaa gctggtccag ctggtgctcc aggtgctcca 900
ggtgctgaag gtgaagaagg tccaccaggt gaagctggtg aaccaggtgc tccaggtcca 960
gaaggtgctg ctggtccagc tggtgaacca ggtccagctg gtgctccagg tccaccaggt 1020
gaagctggtc cagctggtgc tccaggtgaa gctggtgaag aaggtgaacc aggtgctgaa 1080
ggtccagctg gtccagctgg tgaagctggt gctgaaggtg ctccaggtcc accaggtcca 1140
gctggtgctc caggtgaagc tggtccacca ggtccagctg gtgctgaagg tgaagctggt 1200
ccagctggtg ctccaggtgc tccaggtgct gaaggtgaag aaggtccacc aggtgaagct 1260
ggtgaaccag gtgctccagg tccagaaggt gctgct 1296
<210> 187
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 187
Gly Tyr Ala Gly Pro Pro Gly Pro Ala Gly Ala Tyr Gly Tyr Ala Gly
1 5 10 15
Pro Ala Gly Ala Pro Gly Tyr Pro Gly Pro Tyr Gly Pro Pro Gly Pro
20 25 30
Ala Gly Ala Tyr Gly Tyr Ala Gly Pro Ala Gly Ala Pro Gly Tyr Pro
35 40 45
Gly Pro Tyr Gly Pro Pro Gly Tyr Pro Gly Pro Tyr Gly Pro Pro Gly
50 55 60
Tyr Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Tyr Gly Tyr
65 70 75 80
Pro Gly Pro Ala Gly Ala Pro Gly Tyr Ala Gly Pro Pro Gly Pro Ala
85 90 95
Gly Ala Tyr Gly Tyr Ala Gly Pro Ala Gly Ala Pro Gly Tyr Ala Gly
100 105 110
Pro Pro Gly Pro Ala Gly Ala Tyr Gly Tyr Ala Gly Pro Ala Gly Ala
115 120 125
Pro Gly Tyr Pro Gly Pro Tyr Gly Pro Pro Gly Pro Ala Gly Ala Tyr
130 135 140
Gly Tyr Ala Gly Pro Ala Gly Ala Pro Gly Tyr Pro Gly Pro Tyr Gly
145 150 155 160
Pro Pro Gly Tyr Pro Gly Pro Tyr Gly Pro Pro Gly Tyr Ala Gly Ala
165 170 175
Pro Gly Pro Pro Gly Ala Pro Gly Ala Tyr Gly Tyr Pro Gly Pro Ala
180 185 190
Gly Ala Pro Gly Tyr Ala Gly Pro Pro Gly Pro Ala Gly Ala Tyr Gly
195 200 205
Tyr Ala Gly Pro Ala Gly Ala Pro Gly Tyr Ala Gly Pro Pro Gly Pro
210 215 220
Ala Gly Ala Tyr Gly Tyr Ala Gly Pro Ala Gly Ala Pro Gly Tyr Pro
225 230 235 240
Gly Pro Tyr Gly Pro Pro Gly Pro Ala Gly Ala Tyr Gly Tyr Ala Gly
245 250 255
Pro Ala Gly Ala Pro Gly Tyr Pro Gly Pro Tyr Gly Pro Pro Gly Tyr
260 265 270
Pro Gly Pro Tyr Gly Pro Pro Gly Tyr Ala Gly Ala Pro Gly Pro Pro
275 280 285
Gly Ala Pro Gly Ala Tyr Gly Tyr Pro Gly Pro Ala Gly Ala Pro Gly
290 295 300
Tyr Ala Gly Pro Pro Gly Pro Ala Gly Ala Tyr Gly Tyr Ala Gly Pro
305 310 315 320
Ala Gly Ala Pro Gly Tyr Ala Gly Pro Pro Gly Pro Ala Gly Ala Tyr
325 330 335
Gly Tyr Ala Gly Pro Ala Gly Ala Pro Gly Tyr Pro Gly Pro Tyr Gly
340 345 350
Pro Pro Gly Pro Ala Gly Ala Tyr Gly Tyr Ala Gly Pro Ala Gly Ala
355 360 365
Pro Gly Tyr Pro Gly Pro Tyr Gly Pro Pro Gly Tyr Pro Gly Pro Tyr
370 375 380
Gly Pro Pro Gly Tyr Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly
385 390 395 400
Ala Tyr Gly Tyr Pro Gly Pro Ala Gly Ala Pro Gly Tyr Ala Gly Pro
405 410 415
Pro Gly Pro Ala Gly Ala Tyr Gly Tyr Ala Gly Pro Ala Gly Ala Pro
420 425 430
<210> 188
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 188
ggttacgctg gtccaccagg tccagctggt gcttacggtt acgctggtcc agctggtgct 60
ccaggttacc caggtccata cggtccacca ggtccagctg gtgcttacgg ttacgctggt 120
ccagctggtg ctccaggtta cccaggtcca tacggtccac caggttaccc aggtccatac 180
ggtccaccag gttacgctgg tgctccaggt ccaccaggtg ctccaggtgc ttacggttac 240
ccaggtccag ctggtgctcc aggttacgct ggtccaccag gtccagctgg tgcttacggt 300
tacgctggtc cagctggtgc tccaggttac gctggtccac caggtccagc tggtgcttac 360
ggttacgctg gtccagctgg tgctccaggt tacccaggtc catacggtcc accaggtcca 420
gctggtgctt acggttacgc tggtccagct ggtgctccag gttacccagg tccatacggt 480
ccaccaggtt acccaggtcc atacggtcca ccaggttacg ctggtgctcc aggtccacca 540
ggtgctccag gtgcttacgg ttacccaggt ccagctggtg ctccaggtta cgctggtcca 600
ccaggtccag ctggtgctta cggttacgct ggtccagctg gtgctccagg ttacgctggt 660
ccaccaggtc cagctggtgc ttacggttac gctggtccag ctggtgctcc aggttaccca 720
ggtccatacg gtccaccagg tccagctggt gcttacggtt acgctggtcc agctggtgct 780
ccaggttacc caggtccata cggtccacca ggttacccag gtccatacgg tccaccaggt 840
tacgctggtg ctccaggtcc accaggtgct ccaggtgctt acggttaccc aggtccagct 900
ggtgctccag gttacgctgg tccaccaggt ccagctggtg cttacggtta cgctggtcca 960
gctggtgctc caggttacgc tggtccacca ggtccagctg gtgcttacgg ttacgctggt 1020
ccagctggtg ctccaggtta cccaggtcca tacggtccac caggtccagc tggtgcttac 1080
ggttacgctg gtccagctgg tgctccaggt tacccaggtc catacggtcc accaggttac 1140
ccaggtccat acggtccacc aggttacgct ggtgctccag gtccaccagg tgctccaggt 1200
gcttacggtt acccaggtcc agctggtgct ccaggttacg ctggtccacc aggtccagct 1260
ggtgcttacg gttacgctgg tccagctggt gctcca 1296
<210> 189
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 189
Gly Tyr Leu Gly Pro Pro Gly Pro Leu Gly Leu Tyr Gly Tyr Leu Gly
1 5 10 15
Pro Leu Gly Leu Pro Gly Tyr Pro Gly Pro Tyr Gly Pro Pro Gly Pro
20 25 30
Leu Gly Leu Tyr Gly Tyr Leu Gly Pro Leu Gly Leu Pro Gly Tyr Pro
35 40 45
Gly Pro Tyr Gly Pro Pro Gly Tyr Pro Gly Pro Tyr Gly Pro Pro Gly
50 55 60
Tyr Leu Gly Leu Pro Gly Pro Pro Gly Leu Pro Gly Leu Tyr Gly Tyr
65 70 75 80
Pro Gly Pro Leu Gly Leu Pro Gly Tyr Leu Gly Pro Pro Gly Pro Leu
85 90 95
Gly Leu Tyr Gly Tyr Leu Gly Pro Leu Gly Leu Pro Gly Tyr Leu Gly
100 105 110
Pro Pro Gly Pro Leu Gly Leu Tyr Gly Tyr Leu Gly Pro Leu Gly Leu
115 120 125
Pro Gly Tyr Pro Gly Pro Tyr Gly Pro Pro Gly Pro Leu Gly Leu Tyr
130 135 140
Gly Tyr Leu Gly Pro Leu Gly Leu Pro Gly Tyr Pro Gly Pro Tyr Gly
145 150 155 160
Pro Pro Gly Tyr Pro Gly Pro Tyr Gly Pro Pro Gly Tyr Leu Gly Leu
165 170 175
Pro Gly Pro Pro Gly Leu Pro Gly Leu Tyr Gly Tyr Pro Gly Pro Leu
180 185 190
Gly Leu Pro Gly Tyr Leu Gly Pro Pro Gly Pro Leu Gly Leu Tyr Gly
195 200 205
Tyr Leu Gly Pro Leu Gly Leu Pro Gly Tyr Leu Gly Pro Pro Gly Pro
210 215 220
Leu Gly Leu Tyr Gly Tyr Leu Gly Pro Leu Gly Leu Pro Gly Tyr Pro
225 230 235 240
Gly Pro Tyr Gly Pro Pro Gly Pro Leu Gly Leu Tyr Gly Tyr Leu Gly
245 250 255
Pro Leu Gly Leu Pro Gly Tyr Pro Gly Pro Tyr Gly Pro Pro Gly Tyr
260 265 270
Pro Gly Pro Tyr Gly Pro Pro Gly Tyr Leu Gly Leu Pro Gly Pro Pro
275 280 285
Gly Leu Pro Gly Leu Tyr Gly Tyr Pro Gly Pro Leu Gly Leu Pro Gly
290 295 300
Tyr Leu Gly Pro Pro Gly Pro Leu Gly Leu Tyr Gly Tyr Leu Gly Pro
305 310 315 320
Leu Gly Leu Pro Gly Tyr Leu Gly Pro Pro Gly Pro Leu Gly Leu Tyr
325 330 335
Gly Tyr Leu Gly Pro Leu Gly Leu Pro Gly Tyr Pro Gly Pro Tyr Gly
340 345 350
Pro Pro Gly Pro Leu Gly Leu Tyr Gly Tyr Leu Gly Pro Leu Gly Leu
355 360 365
Pro Gly Tyr Pro Gly Pro Tyr Gly Pro Pro Gly Tyr Pro Gly Pro Tyr
370 375 380
Gly Pro Pro Gly Tyr Leu Gly Leu Pro Gly Pro Pro Gly Leu Pro Gly
385 390 395 400
Leu Tyr Gly Tyr Pro Gly Pro Leu Gly Leu Pro Gly Tyr Leu Gly Pro
405 410 415
Pro Gly Pro Leu Gly Leu Tyr Gly Tyr Leu Gly Pro Leu Gly Leu Pro
420 425 430
<210> 190
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 190
ggttacttgg gtccaccagg tccattgggt ttgtacggtt acttgggtcc attgggtttg 60
ccaggttacc caggtccata cggtccacca ggtccattgg gtttgtacgg ttacttgggt 120
ccattgggtt tgccaggtta cccaggtcca tacggtccac caggttaccc aggtccatac 180
ggtccaccag gttacttggg tttgccaggt ccaccaggtt tgccaggttt gtacggttac 240
ccaggtccat tgggtttgcc aggttacttg ggtccaccag gtccattggg tttgtacggt 300
tacttgggtc cattgggttt gccaggttac ttgggtccac caggtccatt gggtttgtac 360
ggttacttgg gtccattggg tttgccaggt tacccaggtc catacggtcc accaggtcca 420
ttgggtttgt acggttactt gggtccattg ggtttgccag gttacccagg tccatacggt 480
ccaccaggtt acccaggtcc atacggtcca ccaggttact tgggtttgcc aggtccacca 540
ggtttgccag gtttgtacgg ttacccaggt ccattgggtt tgccaggtta cttgggtcca 600
ccaggtccat tgggtttgta cggttacttg ggtccattgg gtttgccagg ttacttgggt 660
ccaccaggtc cattgggttt gtacggttac ttgggtccat tgggtttgcc aggttaccca 720
ggtccatacg gtccaccagg tccattgggt ttgtacggtt acttgggtcc attgggtttg 780
ccaggttacc caggtccata cggtccacca ggttacccag gtccatacgg tccaccaggt 840
tacttgggtt tgccaggtcc accaggtttg ccaggtttgt acggttaccc aggtccattg 900
ggtttgccag gttacttggg tccaccaggt ccattgggtt tgtacggtta cttgggtcca 960
ttgggtttgc caggttactt gggtccacca ggtccattgg gtttgtacgg ttacttgggt 1020
ccattgggtt tgccaggtta cccaggtcca tacggtccac caggtccatt gggtttgtac 1080
ggttacttgg gtccattggg tttgccaggt tacccaggtc catacggtcc accaggttac 1140
ccaggtccat acggtccacc aggttacttg ggtttgccag gtccaccagg tttgccaggt 1200
ttgtacggtt acccaggtcc attgggtttg ccaggttact tgggtccacc aggtccattg 1260
ggtttgtacg gttacttggg tccattgggt ttgcca 1296
<210> 191
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 191
Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Ala Asp Gly Asp Ala Gly
1 5 10 15
Pro Ala Gly Ala Pro Gly Asp Pro Gly Pro Asp Gly Pro Pro Gly Pro
20 25 30
Ala Gly Ala Asp Gly Asp Ala Gly Pro Ala Gly Ala Pro Gly Asp Pro
35 40 45
Gly Pro Asp Gly Pro Pro Gly Asp Pro Gly Pro Asp Gly Pro Pro Gly
50 55 60
Asp Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Asp Gly Asp
65 70 75 80
Pro Gly Pro Ala Gly Ala Pro Gly Asp Ala Gly Pro Pro Gly Pro Ala
85 90 95
Gly Ala Asp Gly Asp Ala Gly Pro Ala Gly Ala Pro Gly Asp Ala Gly
100 105 110
Pro Pro Gly Pro Ala Gly Ala Asp Gly Asp Ala Gly Pro Ala Gly Ala
115 120 125
Pro Gly Asp Pro Gly Pro Asp Gly Pro Pro Gly Pro Ala Gly Ala Asp
130 135 140
Gly Asp Ala Gly Pro Ala Gly Ala Pro Gly Asp Pro Gly Pro Asp Gly
145 150 155 160
Pro Pro Gly Asp Pro Gly Pro Asp Gly Pro Pro Gly Asp Ala Gly Ala
165 170 175
Pro Gly Pro Pro Gly Ala Pro Gly Ala Asp Gly Asp Pro Gly Pro Ala
180 185 190
Gly Ala Pro Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Ala Asp Gly
195 200 205
Asp Ala Gly Pro Ala Gly Ala Pro Gly Asp Ala Gly Pro Pro Gly Pro
210 215 220
Ala Gly Ala Asp Gly Asp Ala Gly Pro Ala Gly Ala Pro Gly Asp Pro
225 230 235 240
Gly Pro Asp Gly Pro Pro Gly Pro Ala Gly Ala Asp Gly Asp Ala Gly
245 250 255
Pro Ala Gly Ala Pro Gly Asp Pro Gly Pro Asp Gly Pro Pro Gly Asp
260 265 270
Pro Gly Pro Asp Gly Pro Pro Gly Asp Ala Gly Ala Pro Gly Pro Pro
275 280 285
Gly Ala Pro Gly Ala Asp Gly Asp Pro Gly Pro Ala Gly Ala Pro Gly
290 295 300
Asp Ala Gly Pro Pro Gly Pro Ala Gly Ala Asp Gly Asp Ala Gly Pro
305 310 315 320
Ala Gly Ala Pro Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Ala Asp
325 330 335
Gly Asp Ala Gly Pro Ala Gly Ala Pro Gly Asp Pro Gly Pro Asp Gly
340 345 350
Pro Pro Gly Pro Ala Gly Ala Asp Gly Asp Ala Gly Pro Ala Gly Ala
355 360 365
Pro Gly Asp Pro Gly Pro Asp Gly Pro Pro Gly Asp Pro Gly Pro Asp
370 375 380
Gly Pro Pro Gly Asp Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly
385 390 395 400
Ala Asp Gly Asp Pro Gly Pro Ala Gly Ala Pro Gly Asp Ala Gly Pro
405 410 415
Pro Gly Pro Ala Gly Ala Asp Gly Asp Ala Gly Pro Ala Gly Ala Pro
420 425 430
<210> 192
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 192
ggtgatgctg gtccaccagg tccagctggt gctgatggtg atgctggtcc agctggtgct 60
ccaggtgatc caggtccaga tggtccacca ggtccagctg gtgctgatgg tgatgctggt 120
ccagctggtg ctccaggtga tccaggtcca gatggtccac caggtgatcc aggtccagat 180
ggtccaccag gtgatgctgg tgctccaggt ccaccaggtg ctccaggtgc tgatggtgat 240
ccaggtccag ctggtgctcc aggtgatgct ggtccaccag gtccagctgg tgctgatggt 300
gatgctggtc cagctggtgc tccaggtgat gctggtccac caggtccagc tggtgctgat 360
ggtgatgctg gtccagctgg tgctccaggt gatccaggtc cagatggtcc accaggtcca 420
gctggtgctg atggtgatgc tggtccagct ggtgctccag gtgatccagg tccagatggt 480
ccaccaggtg atccaggtcc agatggtcca ccaggtgatg ctggtgctcc aggtccacca 540
ggtgctccag gtgctgatgg tgatccaggt ccagctggtg ctccaggtga tgctggtcca 600
ccaggtccag ctggtgctga tggtgatgct ggtccagctg gtgctccagg tgatgctggt 660
ccaccaggtc cagctggtgc tgatggtgat gctggtccag ctggtgctcc aggtgatcca 720
ggtccagatg gtccaccagg tccagctggt gctgatggtg atgctggtcc agctggtgct 780
ccaggtgatc caggtccaga tggtccacca ggtgatccag gtccagatgg tccaccaggt 840
gatgctggtg ctccaggtcc accaggtgct ccaggtgctg atggtgatcc aggtccagct 900
ggtgctccag gtgatgctgg tccaccaggt ccagctggtg ctgatggtga tgctggtcca 960
gctggtgctc caggtgatgc tggtccacca ggtccagctg gtgctgatgg tgatgctggt 1020
ccagctggtg ctccaggtga tccaggtcca gatggtccac caggtccagc tggtgctgat 1080
ggtgatgctg gtccagctgg tgctccaggt gatccaggtc cagatggtcc accaggtgat 1140
ccaggtccag atggtccacc aggtgatgct ggtgctccag gtccaccagg tgctccaggt 1200
gctgatggtg atccaggtcc agctggtgct ccaggtgatg ctggtccacc aggtccagct 1260
ggtgctgatg gtgatgctgg tccagctggt gctcca 1296
<210> 193
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 193
Gly Glu Ala Gly Pro His Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
1 5 10 15
His Ala Gly Ala Pro Gly Glu Tyr Gly Pro Glu Gly Pro Tyr Gly Pro
20 25 30
Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Tyr Gly Glu Pro
35 40 45
Gly Pro Glu Gly Pro His Gly Glu Pro Gly Pro Glu Gly Pro Tyr Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro His Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Ala Gly Ala His Gly Glu Ala Gly Pro Pro Gly Tyr Ala
85 90 95
Gly Ala Glu Gly Glu Ala Gly Tyr Ala Gly Ala Pro Gly Glu Ala Gly
100 105 110
Pro His Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly His Ala Gly Ala
115 120 125
Pro Gly Glu Tyr Gly Pro Glu Gly Pro Tyr Gly Pro Ala Gly Ala Glu
130 135 140
Gly Glu Ala Gly Pro Ala Gly Ala Tyr Gly Glu Pro Gly Pro Glu Gly
145 150 155 160
Pro His Gly Glu Pro Gly Pro Glu Gly Pro Tyr Gly Glu Ala Gly Ala
165 170 175
Pro Gly Pro His Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Ala
180 185 190
Gly Ala His Gly Glu Ala Gly Pro Pro Gly Tyr Ala Gly Ala Glu Gly
195 200 205
Glu Ala Gly Tyr Ala Gly Ala Pro Gly Glu Ala Gly Pro His Gly Pro
210 215 220
Ala Gly Ala Glu Gly Glu Ala Gly His Ala Gly Ala Pro Gly Glu Tyr
225 230 235 240
Gly Pro Glu Gly Pro Tyr Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
245 250 255
Pro Ala Gly Ala Tyr Gly Glu Pro Gly Pro Glu Gly Pro His Gly Glu
260 265 270
Pro Gly Pro Glu Gly Pro Tyr Gly Glu Ala Gly Ala Pro Gly Pro His
275 280 285
Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Ala Gly Ala His Gly
290 295 300
Glu Ala Gly Pro Pro Gly Tyr Ala Gly Ala Glu Gly Glu Ala Gly Tyr
305 310 315 320
Ala Gly Ala Pro Gly Glu Ala Gly Pro His Gly Pro Ala Gly Ala Glu
325 330 335
Gly Glu Ala Gly His Ala Gly Ala Pro Gly Glu Tyr Gly Pro Glu Gly
340 345 350
Pro Tyr Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
355 360 365
Tyr Gly Glu Pro Gly Pro Glu Gly Pro His Gly Glu Pro Gly Pro Glu
370 375 380
Gly Pro Tyr Gly Glu Ala Gly Ala Pro Gly Pro His Gly Ala Pro Gly
385 390 395 400
Ala Glu Gly Glu Pro Gly Pro Ala Gly Ala His Gly Glu Ala Gly Pro
405 410 415
Pro Gly Tyr Ala Gly Ala Glu Gly Glu Ala Gly Tyr Ala Gly Ala Pro
420 425 430
<210> 194
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 194
ggtgaagctg gtccacatgg tccagctggt gctgaaggtg aagctggtca tgctggtgct 60
ccaggtgaat acggtccaga aggtccatac ggtccagctg gtgctgaagg tgaagctggt 120
ccagctggtg cttacggtga accaggtcca gaaggtccac atggtgaacc aggtccagaa 180
ggtccatacg gtgaagctgg tgctccaggt ccacatggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag ctggtgctca tggtgaagct ggtccaccag gttacgctgg tgctgaaggt 300
gaagctggtt acgctggtgc tccaggtgaa gctggtccac atggtccagc tggtgctgaa 360
ggtgaagctg gtcatgctgg tgctccaggt gaatacggtc cagaaggtcc atacggtcca 420
gctggtgctg aaggtgaagc tggtccagct ggtgcttacg gtgaaccagg tccagaaggt 480
ccacatggtg aaccaggtcc agaaggtcca tacggtgaag ctggtgctcc aggtccacat 540
ggtgctccag gtgctgaagg tgaaccaggt ccagctggtg ctcatggtga agctggtcca 600
ccaggttacg ctggtgctga aggtgaagct ggttacgctg gtgctccagg tgaagctggt 660
ccacatggtc cagctggtgc tgaaggtgaa gctggtcatg ctggtgctcc aggtgaatac 720
ggtccagaag gtccatacgg tccagctggt gctgaaggtg aagctggtcc agctggtgct 780
tacggtgaac caggtccaga aggtccacat ggtgaaccag gtccagaagg tccatacggt 840
gaagctggtg ctccaggtcc acatggtgct ccaggtgctg aaggtgaacc aggtccagct 900
ggtgctcatg gtgaagctgg tccaccaggt tacgctggtg ctgaaggtga agctggttac 960
gctggtgctc caggtgaagc tggtccacat ggtccagctg gtgctgaagg tgaagctggt 1020
catgctggtg ctccaggtga atacggtcca gaaggtccat acggtccagc tggtgctgaa 1080
ggtgaagctg gtccagctgg tgcttacggt gaaccaggtc cagaaggtcc acatggtgaa 1140
ccaggtccag aaggtccata cggtgaagct ggtgctccag gtccacatgg tgctccaggt 1200
gctgaaggtg aaccaggtcc agctggtgct catggtgaag ctggtccacc aggttacgct 1260
ggtgctgaag gtgaagctgg ttacgctggt gctcca 1296
<210> 195
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 195
Gly Asp Ala Gly Pro Trp Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
1 5 10 15
Pro Ala Gly Ala Pro Gly Glu Trp Gly Pro Glu Gly Pro Asp Gly Pro
20 25 30
Ala Gly Ala Asp Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro
35 40 45
Gly Pro Trp Gly Pro Pro Gly Glu Trp Gly Pro Glu Gly Pro Asp Gly
50 55 60
Glu Ala Gly Ala Trp Gly Pro Pro Gly Ala Pro Gly Ala Asp Gly Glu
65 70 75 80
Pro Gly Pro Trp Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Asp
85 90 95
Gly Ala Glu Gly Glu Ala Gly Pro Trp Gly Ala Pro Gly Asp Ala Gly
100 105 110
Pro Trp Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
115 120 125
Pro Gly Glu Trp Gly Pro Glu Gly Pro Asp Gly Pro Ala Gly Ala Asp
130 135 140
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Trp Gly
145 150 155 160
Pro Pro Gly Glu Trp Gly Pro Glu Gly Pro Asp Gly Glu Ala Gly Ala
165 170 175
Trp Gly Pro Pro Gly Ala Pro Gly Ala Asp Gly Glu Pro Gly Pro Trp
180 185 190
Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Asp Gly Ala Glu Gly
195 200 205
Glu Ala Gly Pro Trp Gly Ala Pro Gly Asp Ala Gly Pro Trp Gly Pro
210 215 220
Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Trp
225 230 235 240
Gly Pro Glu Gly Pro Asp Gly Pro Ala Gly Ala Asp Gly Glu Ala Gly
245 250 255
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Trp Gly Pro Pro Gly Glu
260 265 270
Trp Gly Pro Glu Gly Pro Asp Gly Glu Ala Gly Ala Trp Gly Pro Pro
275 280 285
Gly Ala Pro Gly Ala Asp Gly Glu Pro Gly Pro Trp Gly Ala Pro Gly
290 295 300
Glu Ala Gly Pro Pro Gly Pro Asp Gly Ala Glu Gly Glu Ala Gly Pro
305 310 315 320
Trp Gly Ala Pro Gly Asp Ala Gly Pro Trp Gly Pro Ala Gly Ala Glu
325 330 335
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Trp Gly Pro Glu Gly
340 345 350
Pro Asp Gly Pro Ala Gly Ala Asp Gly Glu Ala Gly Pro Ala Gly Ala
355 360 365
Pro Gly Glu Pro Gly Pro Trp Gly Pro Pro Gly Glu Trp Gly Pro Glu
370 375 380
Gly Pro Asp Gly Glu Ala Gly Ala Trp Gly Pro Pro Gly Ala Pro Gly
385 390 395 400
Ala Asp Gly Glu Pro Gly Pro Trp Gly Ala Pro Gly Glu Ala Gly Pro
405 410 415
Pro Gly Pro Asp Gly Ala Glu Gly Glu Ala Gly Pro Trp Gly Ala Pro
420 425 430
<210> 196
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 196
ggtgatgctg gtccatgggg tccagctggt gctgaaggtg aagctggtcc agctggtgct 60
ccaggtgaat ggggtccaga aggtccagat ggtccagctg gtgctgatgg tgaagctggt 120
ccagctggtg ctccaggtga accaggtcca tggggtccac caggtgaatg gggtccagaa 180
ggtccagatg gtgaagctgg tgcttggggt ccaccaggtg ctccaggtgc tgatggtgaa 240
ccaggtccat ggggtgctcc aggtgaagct ggtccaccag gtccagatgg tgctgaaggt 300
gaagctggtc catggggtgc tccaggtgat gctggtccat ggggtccagc tggtgctgaa 360
ggtgaagctg gtccagctgg tgctccaggt gaatggggtc cagaaggtcc agatggtcca 420
gctggtgctg atggtgaagc tggtccagct ggtgctccag gtgaaccagg tccatggggt 480
ccaccaggtg aatggggtcc agaaggtcca gatggtgaag ctggtgcttg gggtccacca 540
ggtgctccag gtgctgatgg tgaaccaggt ccatggggtg ctccaggtga agctggtcca 600
ccaggtccag atggtgctga aggtgaagct ggtccatggg gtgctccagg tgatgctggt 660
ccatggggtc cagctggtgc tgaaggtgaa gctggtccag ctggtgctcc aggtgaatgg 720
ggtccagaag gtccagatgg tccagctggt gctgatggtg aagctggtcc agctggtgct 780
ccaggtgaac caggtccatg gggtccacca ggtgaatggg gtccagaagg tccagatggt 840
gaagctggtg cttggggtcc accaggtgct ccaggtgctg atggtgaacc aggtccatgg 900
ggtgctccag gtgaagctgg tccaccaggt ccagatggtg ctgaaggtga agctggtcca 960
tggggtgctc caggtgatgc tggtccatgg ggtccagctg gtgctgaagg tgaagctggt 1020
ccagctggtg ctccaggtga atggggtcca gaaggtccag atggtccagc tggtgctgat 1080
ggtgaagctg gtccagctgg tgctccaggt gaaccaggtc catggggtcc accaggtgaa 1140
tggggtccag aaggtccaga tggtgaagct ggtgcttggg gtccaccagg tgctccaggt 1200
gctgatggtg aaccaggtcc atggggtgct ccaggtgaag ctggtccacc aggtccagat 1260
ggtgctgaag gtgaagctgg tccatggggt gctcca 1296
<210> 197
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 197
Gly Glu Ala Gly Pro Trp Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
1 5 10 15
Asp Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Tyr Gly Pro
20 25 30
Ala Gly Ala Glu Gly Glu Ala Gly His Ala Gly Ala Pro Gly Glu Asp
35 40 45
Gly Pro Glu Gly Pro Trp Gly Glu Pro Gly Pro Glu Gly Pro Trp Gly
50 55 60
Glu Ala Gly Asp Pro Gly Pro Tyr Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
His Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro His Gly Pro Ala
85 90 95
Gly Ala Asp Gly Glu Ala Gly Trp Ala Gly Ala Pro Gly Glu Ala Gly
100 105 110
Pro Trp Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Asp Ala Gly Ala
115 120 125
Pro Gly Glu Pro Gly Pro Glu Gly Pro Tyr Gly Pro Ala Gly Ala Glu
130 135 140
Gly Glu Ala Gly His Ala Gly Ala Pro Gly Glu Asp Gly Pro Glu Gly
145 150 155 160
Pro Trp Gly Glu Pro Gly Pro Glu Gly Pro Trp Gly Glu Ala Gly Asp
165 170 175
Pro Gly Pro Tyr Gly Ala Pro Gly Ala Glu Gly Glu His Gly Pro Ala
180 185 190
Gly Ala Pro Gly Glu Ala Gly Pro His Gly Pro Ala Gly Ala Asp Gly
195 200 205
Glu Ala Gly Trp Ala Gly Ala Pro Gly Glu Ala Gly Pro Trp Gly Pro
210 215 220
Ala Gly Ala Glu Gly Glu Ala Gly Asp Ala Gly Ala Pro Gly Glu Pro
225 230 235 240
Gly Pro Glu Gly Pro Tyr Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
245 250 255
His Ala Gly Ala Pro Gly Glu Asp Gly Pro Glu Gly Pro Trp Gly Glu
260 265 270
Pro Gly Pro Glu Gly Pro Trp Gly Glu Ala Gly Asp Pro Gly Pro Tyr
275 280 285
Gly Ala Pro Gly Ala Glu Gly Glu His Gly Pro Ala Gly Ala Pro Gly
290 295 300
Glu Ala Gly Pro His Gly Pro Ala Gly Ala Asp Gly Glu Ala Gly Trp
305 310 315 320
Ala Gly Ala Pro Gly Glu Ala Gly Pro Trp Gly Pro Ala Gly Ala Glu
325 330 335
Gly Glu Ala Gly Asp Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly
340 345 350
Pro Tyr Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly His Ala Gly Ala
355 360 365
Pro Gly Glu Asp Gly Pro Glu Gly Pro Trp Gly Glu Pro Gly Pro Glu
370 375 380
Gly Pro Trp Gly Glu Ala Gly Asp Pro Gly Pro Tyr Gly Ala Pro Gly
385 390 395 400
Ala Glu Gly Glu His Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro
405 410 415
His Gly Pro Ala Gly Ala Asp Gly Glu Ala Gly Trp Ala Gly Ala Pro
420 425 430
<210> 198
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 198
ggtgaagctg gtccatgggg tccagctggt gctgaaggtg aagctggtga tgctggtgct 60
ccaggtgaac caggtccaga aggtccatac ggtccagctg gtgctgaagg tgaagctggt 120
catgctggtg ctccaggtga agatggtcca gaaggtccat ggggtgaacc aggtccagaa 180
ggtccatggg gtgaagctgg tgatccaggt ccatacggtg ctccaggtgc tgaaggtgaa 240
catggtccag ctggtgctcc aggtgaagct ggtccacatg gtccagctgg tgctgatggt 300
gaagctggtt gggctggtgc tccaggtgaa gctggtccat ggggtccagc tggtgctgaa 360
ggtgaagctg gtgatgctgg tgctccaggt gaaccaggtc cagaaggtcc atacggtcca 420
gctggtgctg aaggtgaagc tggtcatgct ggtgctccag gtgaagatgg tccagaaggt 480
ccatggggtg aaccaggtcc agaaggtcca tggggtgaag ctggtgatcc aggtccatac 540
ggtgctccag gtgctgaagg tgaacatggt ccagctggtg ctccaggtga agctggtcca 600
catggtccag ctggtgctga tggtgaagct ggttgggctg gtgctccagg tgaagctggt 660
ccatggggtc cagctggtgc tgaaggtgaa gctggtgatg ctggtgctcc aggtgaacca 720
ggtccagaag gtccatacgg tccagctggt gctgaaggtg aagctggtca tgctggtgct 780
ccaggtgaag atggtccaga aggtccatgg ggtgaaccag gtccagaagg tccatggggt 840
gaagctggtg atccaggtcc atacggtgct ccaggtgctg aaggtgaaca tggtccagct 900
ggtgctccag gtgaagctgg tccacatggt ccagctggtg ctgatggtga agctggttgg 960
gctggtgctc caggtgaagc tggtccatgg ggtccagctg gtgctgaagg tgaagctggt 1020
gatgctggtg ctccaggtga accaggtcca gaaggtccat acggtccagc tggtgctgaa 1080
ggtgaagctg gtcatgctgg tgctccaggt gaagatggtc cagaaggtcc atggggtgaa 1140
ccaggtccag aaggtccatg gggtgaagct ggtgatccag gtccatacgg tgctccaggt 1200
gctgaaggtg aacatggtcc agctggtgct ccaggtgaag ctggtccaca tggtccagct 1260
ggtgctgatg gtgaagctgg ttgggctggt gctcca 1296
<210> 199
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 199
Gly Glu Ala Gly Pro Ser Gly Pro Ala Gly Ala Glu Gly Glu Lys Gly
1 5 10 15
Pro Ala Gly Ala Pro Gly Glu Gln Gly Pro Glu Gly Pro His Gly Pro
20 25 30
Ala Gly Ala Glu Gly Glu His Gly Pro Ala Gly Ala Gln Gly Glu Pro
35 40 45
Gly Pro Glu Gly Pro Ser Gly Glu Pro Gly Pro Glu Gly Pro Lys Gly
50 55 60
Glu Ser Gly Ala Pro Gly Pro Gln Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
His Gly Pro Gln Gly Ala Pro Gly Glu Ala Gly Pro Lys Gly Pro Ala
85 90 95
Gly Ala His Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
100 105 110
Pro Ser Gly Pro Ala Gly Ala Glu Gly Glu Lys Gly Pro Ala Gly Ala
115 120 125
Pro Gly Glu Gln Gly Pro Glu Gly Pro His Gly Pro Ala Gly Ala Glu
130 135 140
Gly Glu His Gly Pro Ala Gly Ala Gln Gly Glu Pro Gly Pro Glu Gly
145 150 155 160
Pro Ser Gly Glu Pro Gly Pro Glu Gly Pro Lys Gly Glu Ser Gly Ala
165 170 175
Pro Gly Pro Gln Gly Ala Pro Gly Ala Glu Gly Glu His Gly Pro Gln
180 185 190
Gly Ala Pro Gly Glu Ala Gly Pro Lys Gly Pro Ala Gly Ala His Gly
195 200 205
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Ser Gly Pro
210 215 220
Ala Gly Ala Glu Gly Glu Lys Gly Pro Ala Gly Ala Pro Gly Glu Gln
225 230 235 240
Gly Pro Glu Gly Pro His Gly Pro Ala Gly Ala Glu Gly Glu His Gly
245 250 255
Pro Ala Gly Ala Gln Gly Glu Pro Gly Pro Glu Gly Pro Ser Gly Glu
260 265 270
Pro Gly Pro Glu Gly Pro Lys Gly Glu Ser Gly Ala Pro Gly Pro Gln
275 280 285
Gly Ala Pro Gly Ala Glu Gly Glu His Gly Pro Gln Gly Ala Pro Gly
290 295 300
Glu Ala Gly Pro Lys Gly Pro Ala Gly Ala His Gly Glu Ala Gly Pro
305 310 315 320
Ala Gly Ala Pro Gly Glu Ala Gly Pro Ser Gly Pro Ala Gly Ala Glu
325 330 335
Gly Glu Lys Gly Pro Ala Gly Ala Pro Gly Glu Gln Gly Pro Glu Gly
340 345 350
Pro His Gly Pro Ala Gly Ala Glu Gly Glu His Gly Pro Ala Gly Ala
355 360 365
Gln Gly Glu Pro Gly Pro Glu Gly Pro Ser Gly Glu Pro Gly Pro Glu
370 375 380
Gly Pro Lys Gly Glu Ser Gly Ala Pro Gly Pro Gln Gly Ala Pro Gly
385 390 395 400
Ala Glu Gly Glu His Gly Pro Gln Gly Ala Pro Gly Glu Ala Gly Pro
405 410 415
Lys Gly Pro Ala Gly Ala His Gly Glu Ala Gly Pro Ala Gly Ala Pro
420 425 430
<210> 200
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 200
ggtgaagctg gtccatctgg tccagctggt gctgaaggtg aaaagggtcc agctggtgct 60
ccaggtgaac aaggtccaga aggtccacat ggtccagctg gtgctgaagg tgaacatggt 120
ccagctggtg ctcaaggtga accaggtcca gaaggtccat ctggtgaacc aggtccagaa 180
ggtccaaagg gtgaatctgg tgctccaggt ccacaaggtg ctccaggtgc tgaaggtgaa 240
catggtccac aaggtgctcc aggtgaagct ggtccaaagg gtccagctgg tgctcatggt 300
gaagctggtc cagctggtgc tccaggtgaa gctggtccat ctggtccagc tggtgctgaa 360
ggtgaaaagg gtccagctgg tgctccaggt gaacaaggtc cagaaggtcc acatggtcca 420
gctggtgctg aaggtgaaca tggtccagct ggtgctcaag gtgaaccagg tccagaaggt 480
ccatctggtg aaccaggtcc agaaggtcca aagggtgaat ctggtgctcc aggtccacaa 540
ggtgctccag gtgctgaagg tgaacatggt ccacaaggtg ctccaggtga agctggtcca 600
aagggtccag ctggtgctca tggtgaagct ggtccagctg gtgctccagg tgaagctggt 660
ccatctggtc cagctggtgc tgaaggtgaa aagggtccag ctggtgctcc aggtgaacaa 720
ggtccagaag gtccacatgg tccagctggt gctgaaggtg aacatggtcc agctggtgct 780
caaggtgaac caggtccaga aggtccatct ggtgaaccag gtccagaagg tccaaagggt 840
gaatctggtg ctccaggtcc acaaggtgct ccaggtgctg aaggtgaaca tggtccacaa 900
ggtgctccag gtgaagctgg tccaaagggt ccagctggtg ctcatggtga agctggtcca 960
gctggtgctc caggtgaagc tggtccatct ggtccagctg gtgctgaagg tgaaaagggt 1020
ccagctggtg ctccaggtga acaaggtcca gaaggtccac atggtccagc tggtgctgaa 1080
ggtgaacatg gtccagctgg tgctcaaggt gaaccaggtc cagaaggtcc atctggtgaa 1140
ccaggtccag aaggtccaaa gggtgaatct ggtgctccag gtccacaagg tgctccaggt 1200
gctgaaggtg aacatggtcc acaaggtgct ccaggtgaag ctggtccaaa gggtccagct 1260
ggtgctcatg gtgaagctgg tccagctggt gctcca 1296
<210> 201
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 201
Gly Asp Asn Gly Pro Leu Gly Pro Asn Gly Asn Ser Gly Asp Leu Gly
1 5 10 15
Pro Asn Gly Asn Gln Gly Asp Pro Gly Pro Asp Gly Pro Asn Gly Pro
20 25 30
Asn Gly Asn Asp Gly Asp Asn Gly Pro Trp Gly Asn Pro Gly Asp Pro
35 40 45
Gly Pro Asp Gly Pro Lys Gly Asp Pro Gly Pro Asp Gly Pro Arg Gly
50 55 60
Asp Asn Gly Asn Pro Gly Pro Ser Gly Asn Pro Gly Asn Asp Gly Asp
65 70 75 80
Pro Gly Pro Asn Gly Asn Pro Gly Asp Asn Gly Pro Asn Gly Pro Asn
85 90 95
Gly Asn Asp Gly Asp Ser Gly Pro Pro Gly Asn Pro Gly Asp Asn Gly
100 105 110
Pro Leu Gly Pro Asn Gly Asn Ser Gly Asp Leu Gly Pro Asn Gly Asn
115 120 125
Gln Gly Asp Pro Gly Pro Asp Gly Pro Asn Gly Pro Asn Gly Asn Asp
130 135 140
Gly Asp Asn Gly Pro Trp Gly Asn Pro Gly Asp Pro Gly Pro Asp Gly
145 150 155 160
Pro Lys Gly Asp Pro Gly Pro Asp Gly Pro Arg Gly Asp Asn Gly Asn
165 170 175
Pro Gly Pro Ser Gly Asn Pro Gly Asn Asp Gly Asp Pro Gly Pro Asn
180 185 190
Gly Asn Pro Gly Asp Asn Gly Pro Asn Gly Pro Asn Gly Asn Asp Gly
195 200 205
Asp Ser Gly Pro Pro Gly Asn Pro Gly Asp Asn Gly Pro Leu Gly Pro
210 215 220
Asn Gly Asn Ser Gly Asp Leu Gly Pro Asn Gly Asn Gln Gly Asp Pro
225 230 235 240
Gly Pro Asp Gly Pro Asn Gly Pro Asn Gly Asn Asp Gly Asp Asn Gly
245 250 255
Pro Trp Gly Asn Pro Gly Asp Pro Gly Pro Asp Gly Pro Lys Gly Asp
260 265 270
Pro Gly Pro Asp Gly Pro Arg Gly Asp Asn Gly Asn Pro Gly Pro Ser
275 280 285
Gly Asn Pro Gly Asn Asp Gly Asp Pro Gly Pro Asn Gly Asn Pro Gly
290 295 300
Asp Asn Gly Pro Asn Gly Pro Asn Gly Asn Asp Gly Asp Ser Gly Pro
305 310 315 320
Pro Gly Asn Pro Gly Asp Asn Gly Pro Leu Gly Pro Asn Gly Asn Ser
325 330 335
Gly Asp Leu Gly Pro Asn Gly Asn Gln Gly Asp Pro Gly Pro Asp Gly
340 345 350
Pro Asn Gly Pro Asn Gly Asn Asp Gly Asp Asn Gly Pro Trp Gly Asn
355 360 365
Pro Gly Asp Pro Gly Pro Asp Gly Pro Lys Gly Asp Pro Gly Pro Asp
370 375 380
Gly Pro Arg Gly Asp Asn Gly Asn Pro Gly Pro Ser Gly Asn Pro Gly
385 390 395 400
Asn Asp Gly Asp Pro Gly Pro Asn Gly Asn Pro Gly Asp Asn Gly Pro
405 410 415
Asn Gly Pro Asn Gly Asn Asp Gly Asp Ser Gly Pro Pro Gly Asn Pro
420 425 430
<210> 202
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 202
ggtgataacg gtccattggg tccaaacggt aactctggtg atttgggtcc aaacggtaac 60
caaggtgatc caggtccaga tggtccaaac ggtccaaacg gtaacgatgg tgataacggt 120
ccatggggta acccaggtga tccaggtcca gatggtccaa agggtgatcc aggtccagat 180
ggtccaagag gtgataacgg taacccaggt ccatctggta acccaggtaa cgatggtgat 240
ccaggtccaa acggtaaccc aggtgataac ggtccaaacg gtccaaacgg taacgatggt 300
gattctggtc caccaggtaa cccaggtgat aacggtccat tgggtccaaa cggtaactct 360
ggtgatttgg gtccaaacgg taaccaaggt gatccaggtc cagatggtcc aaacggtcca 420
aacggtaacg atggtgataa cggtccatgg ggtaacccag gtgatccagg tccagatggt 480
ccaaagggtg atccaggtcc agatggtcca agaggtgata acggtaaccc aggtccatct 540
ggtaacccag gtaacgatgg tgatccaggt ccaaacggta acccaggtga taacggtcca 600
aacggtccaa acggtaacga tggtgattct ggtccaccag gtaacccagg tgataacggt 660
ccattgggtc caaacggtaa ctctggtgat ttgggtccaa acggtaacca aggtgatcca 720
ggtccagatg gtccaaacgg tccaaacggt aacgatggtg ataacggtcc atggggtaac 780
ccaggtgatc caggtccaga tggtccaaag ggtgatccag gtccagatgg tccaagaggt 840
gataacggta acccaggtcc atctggtaac ccaggtaacg atggtgatcc aggtccaaac 900
ggtaacccag gtgataacgg tccaaacggt ccaaacggta acgatggtga ttctggtcca 960
ccaggtaacc caggtgataa cggtccattg ggtccaaacg gtaactctgg tgatttgggt 1020
ccaaacggta accaaggtga tccaggtcca gatggtccaa acggtccaaa cggtaacgat 1080
ggtgataacg gtccatgggg taacccaggt gatccaggtc cagatggtcc aaagggtgat 1140
ccaggtccag atggtccaag aggtgataac ggtaacccag gtccatctgg taacccaggt 1200
aacgatggtg atccaggtcc aaacggtaac ccaggtgata acggtccaaa cggtccaaac 1260
ggtaacgatg gtgattctgg tccaccaggt aaccca 1296
<210> 203
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 203
Gly Glu Phe Gly Pro Tyr Gly Pro Val Gly Phe Glu Gly Glu Phe Gly
1 5 10 15
Pro Phe Gly Asn Pro Gly Glu Tyr Gly Pro Glu Gly Pro Trp Gly Pro
20 25 30
Phe Gly Phe Glu Gly Glu Trp Gly Pro Phe Gly Phe Pro Gly Glu Pro
35 40 45
Gly Pro Glu Gly Pro Trp Gly Glu Pro Gly Pro Glu Gly Pro Gln Gly
50 55 60
Glu Phe Gly Tyr Pro Gly Pro Pro Gly Phe Pro Gly Val Glu Gly Glu
65 70 75 80
Pro Gly Pro Asp Gly Phe Pro Gly Glu Asn Gly Pro Gln Gly Pro Phe
85 90 95
Gly Val Glu Gly Glu Phe Gly Pro Trp Gly Phe Pro Gly Glu Phe Gly
100 105 110
Pro Tyr Gly Pro Val Gly Phe Glu Gly Glu Phe Gly Pro Phe Gly Asn
115 120 125
Pro Gly Glu Tyr Gly Pro Glu Gly Pro Trp Gly Pro Phe Gly Phe Glu
130 135 140
Gly Glu Trp Gly Pro Phe Gly Phe Pro Gly Glu Pro Gly Pro Glu Gly
145 150 155 160
Pro Trp Gly Glu Pro Gly Pro Glu Gly Pro Gln Gly Glu Phe Gly Tyr
165 170 175
Pro Gly Pro Pro Gly Phe Pro Gly Val Glu Gly Glu Pro Gly Pro Asp
180 185 190
Gly Phe Pro Gly Glu Asn Gly Pro Gln Gly Pro Phe Gly Val Glu Gly
195 200 205
Glu Phe Gly Pro Trp Gly Phe Pro Gly Glu Phe Gly Pro Tyr Gly Pro
210 215 220
Val Gly Phe Glu Gly Glu Phe Gly Pro Phe Gly Asn Pro Gly Glu Tyr
225 230 235 240
Gly Pro Glu Gly Pro Trp Gly Pro Phe Gly Phe Glu Gly Glu Trp Gly
245 250 255
Pro Phe Gly Phe Pro Gly Glu Pro Gly Pro Glu Gly Pro Trp Gly Glu
260 265 270
Pro Gly Pro Glu Gly Pro Gln Gly Glu Phe Gly Tyr Pro Gly Pro Pro
275 280 285
Gly Phe Pro Gly Val Glu Gly Glu Pro Gly Pro Asp Gly Phe Pro Gly
290 295 300
Glu Asn Gly Pro Gln Gly Pro Phe Gly Val Glu Gly Glu Phe Gly Pro
305 310 315 320
Trp Gly Phe Pro Gly Glu Phe Gly Pro Tyr Gly Pro Val Gly Phe Glu
325 330 335
Gly Glu Phe Gly Pro Phe Gly Asn Pro Gly Glu Tyr Gly Pro Glu Gly
340 345 350
Pro Trp Gly Pro Phe Gly Phe Glu Gly Glu Trp Gly Pro Phe Gly Phe
355 360 365
Pro Gly Glu Pro Gly Pro Glu Gly Pro Trp Gly Glu Pro Gly Pro Glu
370 375 380
Gly Pro Gln Gly Glu Phe Gly Tyr Pro Gly Pro Pro Gly Phe Pro Gly
385 390 395 400
Val Glu Gly Glu Pro Gly Pro Asp Gly Phe Pro Gly Glu Asn Gly Pro
405 410 415
Gln Gly Pro Phe Gly Val Glu Gly Glu Phe Gly Pro Trp Gly Phe Pro
420 425 430
<210> 204
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 204
ggtgaatttg gtccatacgg tccagttggt tttgaaggtg aatttggtcc atttggtaac 60
ccaggtgaat acggtccaga aggtccatgg ggtccatttg gttttgaagg tgaatggggt 120
ccatttggtt ttccaggtga accaggtcca gaaggtccat ggggtgaacc aggtccagaa 180
ggtccacaag gtgaatttgg ttacccaggt ccaccaggtt ttccaggtgt tgaaggtgaa 240
ccaggtccag atggttttcc aggtgaaaac ggtccacaag gtccatttgg tgttgaaggt 300
gaatttggtc catggggttt tccaggtgaa tttggtccat acggtccagt tggttttgaa 360
ggtgaatttg gtccatttgg taacccaggt gaatacggtc cagaaggtcc atggggtcca 420
tttggttttg aaggtgaatg gggtccattt ggttttccag gtgaaccagg tccagaaggt 480
ccatggggtg aaccaggtcc agaaggtcca caaggtgaat ttggttaccc aggtccacca 540
ggttttccag gtgttgaagg tgaaccaggt ccagatggtt ttccaggtga aaacggtcca 600
caaggtccat ttggtgttga aggtgaattt ggtccatggg gttttccagg tgaatttggt 660
ccatacggtc cagttggttt tgaaggtgaa tttggtccat ttggtaaccc aggtgaatac 720
ggtccagaag gtccatgggg tccatttggt tttgaaggtg aatggggtcc atttggtttt 780
ccaggtgaac caggtccaga aggtccatgg ggtgaaccag gtccagaagg tccacaaggt 840
gaatttggtt acccaggtcc accaggtttt ccaggtgttg aaggtgaacc aggtccagat 900
ggttttccag gtgaaaacgg tccacaaggt ccatttggtg ttgaaggtga atttggtcca 960
tggggttttc caggtgaatt tggtccatac ggtccagttg gttttgaagg tgaatttggt 1020
ccatttggta acccaggtga atacggtcca gaaggtccat ggggtccatt tggttttgaa 1080
ggtgaatggg gtccatttgg ttttccaggt gaaccaggtc cagaaggtcc atggggtgaa 1140
ccaggtccag aaggtccaca aggtgaattt ggttacccag gtccaccagg ttttccaggt 1200
gttgaaggtg aaccaggtcc agatggtttt ccaggtgaaa acggtccaca aggtccattt 1260
ggtgttgaag gtgaatttgg tccatggggt tttcca 1296
<210> 205
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 205
Gly Glu Phe Gly Pro Tyr Gly Pro Val Gly Ile Glu Gly Glu Asn Gly
1 5 10 15
Pro Ile Gly Gln Pro Gly Glu Trp Gly Pro Glu Gly Pro Tyr Gly Pro
20 25 30
Ile Gly Ile Glu Gly Asp Gln Gly Pro Ile Gly Lys Pro Gly Glu Trp
35 40 45
Gly Pro Glu Gly Pro Gln Gly Glu Pro Gly Pro Glu Gly Pro Asp Gly
50 55 60
Glu Ile Gly Val Pro Gly Pro Lys Gly Asp Pro Gly Ile Glu Gly Asp
65 70 75 80
Pro Gly Pro Gln Gly Ile Pro Gly Glu Ile Gly Pro Phe Gly Pro Trp
85 90 95
Gly Phe Asp Gly Glu Ile Gly Pro Asn Gly Ile Pro Gly Glu Phe Gly
100 105 110
Pro Tyr Gly Pro Val Gly Ile Glu Gly Glu Asn Gly Pro Ile Gly Gln
115 120 125
Pro Gly Glu Trp Gly Pro Glu Gly Pro Tyr Gly Pro Ile Gly Ile Glu
130 135 140
Gly Asp Gln Gly Pro Ile Gly Lys Pro Gly Glu Trp Gly Pro Glu Gly
145 150 155 160
Pro Gln Gly Glu Pro Gly Pro Glu Gly Pro Asp Gly Glu Ile Gly Val
165 170 175
Pro Gly Pro Lys Gly Asp Pro Gly Ile Glu Gly Asp Pro Gly Pro Gln
180 185 190
Gly Ile Pro Gly Glu Ile Gly Pro Phe Gly Pro Trp Gly Phe Asp Gly
195 200 205
Glu Ile Gly Pro Asn Gly Ile Pro Gly Glu Phe Gly Pro Tyr Gly Pro
210 215 220
Val Gly Ile Glu Gly Glu Asn Gly Pro Ile Gly Gln Pro Gly Glu Trp
225 230 235 240
Gly Pro Glu Gly Pro Tyr Gly Pro Ile Gly Ile Glu Gly Asp Gln Gly
245 250 255
Pro Ile Gly Lys Pro Gly Glu Trp Gly Pro Glu Gly Pro Gln Gly Glu
260 265 270
Pro Gly Pro Glu Gly Pro Asp Gly Glu Ile Gly Val Pro Gly Pro Lys
275 280 285
Gly Asp Pro Gly Ile Glu Gly Asp Pro Gly Pro Gln Gly Ile Pro Gly
290 295 300
Glu Ile Gly Pro Phe Gly Pro Trp Gly Phe Asp Gly Glu Ile Gly Pro
305 310 315 320
Asn Gly Ile Pro Gly Glu Phe Gly Pro Tyr Gly Pro Val Gly Ile Glu
325 330 335
Gly Glu Asn Gly Pro Ile Gly Gln Pro Gly Glu Trp Gly Pro Glu Gly
340 345 350
Pro Tyr Gly Pro Ile Gly Ile Glu Gly Asp Gln Gly Pro Ile Gly Lys
355 360 365
Pro Gly Glu Trp Gly Pro Glu Gly Pro Gln Gly Glu Pro Gly Pro Glu
370 375 380
Gly Pro Asp Gly Glu Ile Gly Val Pro Gly Pro Lys Gly Asp Pro Gly
385 390 395 400
Ile Glu Gly Asp Pro Gly Pro Gln Gly Ile Pro Gly Glu Ile Gly Pro
405 410 415
Phe Gly Pro Trp Gly Phe Asp Gly Glu Ile Gly Pro Asn Gly Ile Pro
420 425 430
<210> 206
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 206
ggtgaatttg gtccatacgg tccagttggt attgaaggtg aaaacggtcc aattggtcaa 60
ccaggtgaat ggggtccaga aggtccatac ggtccaattg gtattgaagg tgatcaaggt 120
ccaattggta agccaggtga atggggtcca gaaggtccac aaggtgaacc aggtccagaa 180
ggtccagatg gtgaaattgg tgttccaggt ccaaagggtg atccaggtat tgaaggtgat 240
ccaggtccac aaggtattcc aggtgaaatt ggtccatttg gtccatgggg ttttgatggt 300
gaaattggtc caaacggtat tccaggtgaa tttggtccat acggtccagt tggtattgaa 360
ggtgaaaacg gtccaattgg tcaaccaggt gaatggggtc cagaaggtcc atacggtcca 420
attggtattg aaggtgatca aggtccaatt ggtaagccag gtgaatgggg tccagaaggt 480
ccacaaggtg aaccaggtcc agaaggtcca gatggtgaaa ttggtgttcc aggtccaaag 540
ggtgatccag gtattgaagg tgatccaggt ccacaaggta ttccaggtga aattggtcca 600
tttggtccat ggggttttga tggtgaaatt ggtccaaacg gtattccagg tgaatttggt 660
ccatacggtc cagttggtat tgaaggtgaa aacggtccaa ttggtcaacc aggtgaatgg 720
ggtccagaag gtccatacgg tccaattggt attgaaggtg atcaaggtcc aattggtaag 780
ccaggtgaat ggggtccaga aggtccacaa ggtgaaccag gtccagaagg tccagatggt 840
gaaattggtg ttccaggtcc aaagggtgat ccaggtattg aaggtgatcc aggtccacaa 900
ggtattccag gtgaaattgg tccatttggt ccatggggtt ttgatggtga aattggtcca 960
aacggtattc caggtgaatt tggtccatac ggtccagttg gtattgaagg tgaaaacggt 1020
ccaattggtc aaccaggtga atggggtcca gaaggtccat acggtccaat tggtattgaa 1080
ggtgatcaag gtccaattgg taagccaggt gaatggggtc cagaaggtcc acaaggtgaa 1140
ccaggtccag aaggtccaga tggtgaaatt ggtgttccag gtccaaaggg tgatccaggt 1200
attgaaggtg atccaggtcc acaaggtatt ccaggtgaaa ttggtccatt tggtccatgg 1260
ggttttgatg gtgaaattgg tccaaacggt attcca 1296
<210> 207
<211> 432
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 207
Gly Glu Phe Gly Pro Tyr Gly Pro Val Gly Ser Glu Gly Glu Asn Gly
1 5 10 15
Pro Thr Gly Gln Pro Gly Glu Trp Gly Pro Glu Gly Pro Tyr Gly Pro
20 25 30
Ser Gly Ser Glu Gly Asp Gln Gly Pro Thr Gly Lys Pro Gly Glu Trp
35 40 45
Gly Pro Glu Gly Pro Gln Gly Glu Pro Gly Pro Glu Gly Pro Asp Gly
50 55 60
Glu Ser Gly Val Pro Gly Pro Lys Gly Asp Pro Gly Ser Glu Gly Asp
65 70 75 80
Pro Gly Pro Gln Gly Leu Pro Gly Glu Ser Gly Pro Phe Gly Pro Trp
85 90 95
Gly Phe Asp Gly Glu Ser Gly Pro Asn Gly Leu Pro Gly Glu Phe Gly
100 105 110
Pro Tyr Gly Pro Val Gly Ser Glu Gly Glu Asn Gly Pro Thr Gly Gln
115 120 125
Pro Gly Glu Trp Gly Pro Glu Gly Pro Tyr Gly Pro Ser Gly Ser Glu
130 135 140
Gly Asp Gln Gly Pro Thr Gly Lys Pro Gly Glu Trp Gly Pro Glu Gly
145 150 155 160
Pro Gln Gly Glu Pro Gly Pro Glu Gly Pro Asp Gly Glu Ser Gly Val
165 170 175
Pro Gly Pro Lys Gly Asp Pro Gly Ser Glu Gly Asp Pro Gly Pro Gln
180 185 190
Gly Leu Pro Gly Glu Ser Gly Pro Phe Gly Pro Trp Gly Phe Asp Gly
195 200 205
Glu Ser Gly Pro Asn Gly Leu Pro Gly Glu Phe Gly Pro Tyr Gly Pro
210 215 220
Val Gly Ser Glu Gly Glu Asn Gly Pro Thr Gly Gln Pro Gly Glu Trp
225 230 235 240
Gly Pro Glu Gly Pro Tyr Gly Pro Ser Gly Ser Glu Gly Asp Gln Gly
245 250 255
Pro Thr Gly Lys Pro Gly Glu Trp Gly Pro Glu Gly Pro Gln Gly Glu
260 265 270
Pro Gly Pro Glu Gly Pro Asp Gly Glu Ser Gly Val Pro Gly Pro Lys
275 280 285
Gly Asp Pro Gly Ser Glu Gly Asp Pro Gly Pro Gln Gly Leu Pro Gly
290 295 300
Glu Ser Gly Pro Phe Gly Pro Trp Gly Phe Asp Gly Glu Ser Gly Pro
305 310 315 320
Asn Gly Leu Pro Gly Glu Phe Gly Pro Tyr Gly Pro Val Gly Ser Glu
325 330 335
Gly Glu Asn Gly Pro Thr Gly Gln Pro Gly Glu Trp Gly Pro Glu Gly
340 345 350
Pro Tyr Gly Pro Ser Gly Ser Glu Gly Asp Gln Gly Pro Thr Gly Lys
355 360 365
Pro Gly Glu Trp Gly Pro Glu Gly Pro Gln Gly Glu Pro Gly Pro Glu
370 375 380
Gly Pro Asp Gly Glu Ser Gly Val Pro Gly Pro Lys Gly Asp Pro Gly
385 390 395 400
Ser Glu Gly Asp Pro Gly Pro Gln Gly Leu Pro Gly Glu Ser Gly Pro
405 410 415
Phe Gly Pro Trp Gly Phe Asp Gly Glu Ser Gly Pro Asn Gly Leu Pro
420 425 430
<210> 208
<211> 1296
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 208
ggtgaatttg gtccatacgg tccagttggt tctgaaggtg aaaacggtcc aactggtcaa 60
ccaggtgaat ggggtccaga aggtccatac ggtccatctg gttctgaagg tgatcaaggt 120
ccaactggta agccaggtga atggggtcca gaaggtccac aaggtgaacc aggtccagaa 180
ggtccagatg gtgaatctgg tgttccaggt ccaaagggtg atccaggttc tgaaggtgat 240
ccaggtccac aaggtttgcc aggtgaatct ggtccatttg gtccatgggg ttttgatggt 300
gaatctggtc caaacggttt gccaggtgaa tttggtccat acggtccagt tggttctgaa 360
ggtgaaaacg gtccaactgg tcaaccaggt gaatggggtc cagaaggtcc atacggtcca 420
tctggttctg aaggtgatca aggtccaact ggtaagccag gtgaatgggg tccagaaggt 480
ccacaaggtg aaccaggtcc agaaggtcca gatggtgaat ctggtgttcc aggtccaaag 540
ggtgatccag gttctgaagg tgatccaggt ccacaaggtt tgccaggtga atctggtcca 600
tttggtccat ggggttttga tggtgaatct ggtccaaacg gtttgccagg tgaatttggt 660
ccatacggtc cagttggttc tgaaggtgaa aacggtccaa ctggtcaacc aggtgaatgg 720
ggtccagaag gtccatacgg tccatctggt tctgaaggtg atcaaggtcc aactggtaag 780
ccaggtgaat ggggtccaga aggtccacaa ggtgaaccag gtccagaagg tccagatggt 840
gaatctggtg ttccaggtcc aaagggtgat ccaggttctg aaggtgatcc aggtccacaa 900
ggtttgccag gtgaatctgg tccatttggt ccatggggtt ttgatggtga atctggtcca 960
aacggtttgc caggtgaatt tggtccatac ggtccagttg gttctgaagg tgaaaacggt 1020
ccaactggtc aaccaggtga atggggtcca gaaggtccat acggtccatc tggttctgaa 1080
ggtgatcaag gtccaactgg taagccaggt gaatggggtc cagaaggtcc acaaggtgaa 1140
ccaggtccag aaggtccaga tggtgaatct ggtgttccag gtccaaaggg tgatccaggt 1200
tctgaaggtg atccaggtcc acaaggtttg ccaggtgaat ctggtccatt tggtccatgg 1260
ggttttgatg gtgaatctgg tccaaacggt ttgcca 1296
<210> 209
<211> 438
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 209
Gly Pro Pro Gly Glu Gln Gly Lys Pro Gly Asn Gln Gly Glu Pro Gly
1 5 10 15
Asn Pro Gly Ser Pro Gly Gln Pro Gly Asn Pro Gly Gln Pro Gly Ser
20 25 30
Pro Gly Asn Pro Gly Gln Pro Gly Asn Glu Gly Pro Gln Gly Ser Gln
35 40 45
Gly Asn Pro Gly Gln Pro Gly Glu Pro Gly Ser Asn Gly Gln Pro Gly
50 55 60
Gln Pro Gly Gln Asn Gly Lys Asn Gly Gln Pro Gly Ser Pro Gly Ser
65 70 75 80
Gln Gly Ser Pro Gly Asn Gln Gly Ser Pro Gly Asn Gln Gly Gln Pro
85 90 95
Gly Asn Lys Gly Glu Gln Gly Lys Pro Gly Asn Gln Gly Pro Ala Gly
100 105 110
Glu Gln Gly Lys Pro Gly Asn Gln Gly Glu Pro Gly Asn Pro Gly Ser
115 120 125
Pro Gly Gln Pro Gly Asn Pro Gly Gln Pro Gly Ser Pro Gly Asn Pro
130 135 140
Gly Gln Pro Gly Asn Glu Gly Pro Gln Gly Ser Gln Gly Asn Pro Gly
145 150 155 160
Gln Pro Gly Glu Pro Gly Ser Asn Gly Gln Pro Gly Gln Pro Gly Gln
165 170 175
Asn Gly Lys Asn Gly Gln Pro Gly Ser Pro Gly Ser Gln Gly Ser Pro
180 185 190
Gly Asn Gln Gly Ser Pro Gly Asn Gln Gly Gln Pro Gly Asn Lys Gly
195 200 205
Glu Gln Gly Lys Pro Gly Asn Gln Gly Pro Ala Gly Glu Gln Gly Lys
210 215 220
Pro Gly Asn Gln Gly Glu Pro Gly Asn Pro Gly Ser Pro Gly Gln Pro
225 230 235 240
Gly Asn Pro Gly Gln Pro Gly Ser Pro Gly Asn Pro Gly Gln Pro Gly
245 250 255
Asn Glu Gly Pro Gln Gly Ser Gln Gly Asn Pro Gly Gln Pro Gly Glu
260 265 270
Pro Gly Ser Asn Gly Gln Pro Gly Gln Pro Gly Gln Asn Gly Lys Asn
275 280 285
Gly Gln Pro Gly Ser Pro Gly Ser Gln Gly Ser Pro Gly Asn Gln Gly
290 295 300
Ser Pro Gly Asn Gln Gly Gln Pro Gly Asn Lys Gly Glu Gln Gly Lys
305 310 315 320
Pro Gly Asn Gln Gly Pro Ala Gly Glu Gln Gly Lys Pro Gly Asn Gln
325 330 335
Gly Glu Pro Gly Asn Pro Gly Ser Pro Gly Gln Pro Gly Asn Pro Gly
340 345 350
Gln Pro Gly Ser Pro Gly Asn Pro Gly Gln Pro Gly Asn Glu Gly Pro
355 360 365
Gln Gly Ser Gln Gly Asn Pro Gly Gln Pro Gly Glu Pro Gly Ser Asn
370 375 380
Gly Gln Pro Gly Gln Pro Gly Gln Asn Gly Lys Asn Gly Gln Pro Gly
385 390 395 400
Ser Pro Gly Ser Gln Gly Ser Pro Gly Asn Gln Gly Ser Pro Gly Asn
405 410 415
Gln Gly Gln Pro Gly Asn Lys Gly Glu Gln Gly Lys Pro Gly Asn Gln
420 425 430
Gly Pro Ala Gly Gly Ser
435
<210> 210
<211> 1314
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 210
ggtccacccg gtgaacaagg taaaccagga aaccagggtg agccaggtaa cccaggttcc 60
cctggtcagc caggtaaccc tggtcaacca ggttctccag gtaatccagg tcaaccagga 120
aacgaaggtc cacaaggttc tcagggtaac cctggacaac ctggtgagcc aggttccaac 180
ggtcaacctg gtcaacctgg tcagaacgga aagaatggtc aacctggatc cccaggttca 240
caaggctctc caggtaacca aggatctcct ggtaaccaag gacagcccgg taacaagggt 300
gaacaaggta aaccaggaaa ccagggtcca gccggtgaac aaggtaaacc aggaaaccag 360
ggtgagccag gtaacccagg ttcccctggt cagccaggta accctggtca accaggttct 420
ccaggtaatc caggtcaacc aggaaacgaa ggtccacaag gttctcaggg taaccctgga 480
caacctggtg agccaggttc caacggtcaa cctggtcaac ctggtcagaa cggaaagaat 540
ggtcaacctg gatccccagg ttcacaaggc tctccaggta accaaggatc tcctggtaac 600
caaggacagc ccggtaacaa gggtgaacaa ggtaaaccag gaaaccaggg tccagccggt 660
gaacaaggta aaccaggaaa ccagggtgag ccaggtaacc caggttcccc tggtcagcca 720
ggtaaccctg gtcaaccagg ttctccaggt aatccaggtc aaccaggaaa cgaaggtcca 780
caaggttctc agggtaaccc tggacaacct ggtgagccag gttccaacgg tcaacctggt 840
caacctggtc agaacggaaa gaatggtcaa cctggatccc caggttcaca aggctctcca 900
ggtaaccaag gatctcctgg taaccaagga cagcccggta acaagggtga acaaggtaaa 960
ccaggaaacc agggtccagc cggtgaacaa ggtaaaccag gaaaccaggg tgagccaggt 1020
aacccaggtt cccctggtca gccaggtaac cctggtcaac caggttctcc aggtaatcca 1080
ggtcaaccag gaaacgaagg tccacaaggt tctcagggta accctggaca acctggtgag 1140
ccaggttcca acggtcaacc tggtcaacct ggtcagaacg gaaagaatgg tcaacctgga 1200
tccccaggtt cacaaggctc tccaggtaac caaggatctc ctggtaacca aggacagccc 1260
ggtaacaagg gtgaacaagg taaaccagga aaccagggtc cagccggtgg ctct 1314
<210> 211
<211> 440
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 211
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Gly Ser Ala Lys Ser Arg Thr Ile Gly Ile
115 120 125
Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro Arg Gly Gly Val Glu Glu
130 135 140
Gly Pro Thr Val Leu Arg Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu
145 150 155 160
Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile
165 170 175
Pro Asn Asp Ser Pro Phe Gln Ile Val Lys Asn Pro Arg Ser Val Gly
180 185 190
Lys Ala Ser Glu Gln Leu Ala Gly Lys Val Ala Glu Val Lys Lys Asn
195 200 205
Gly Arg Ile Ser Leu Val Leu Gly Gly Asp His Ser Leu Ala Ile Gly
210 215 220
Ser Ile Ser Gly His Ala Arg Val His Pro Asp Leu Gly Val Ile Trp
225 230 235 240
Val Asp Ala His Thr Asp Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly
245 250 255
Asn Leu His Gly Gln Pro Val Ser Phe Leu Leu Lys Glu Leu Lys Gly
260 265 270
Lys Ile Pro Asp Val Pro Gly Phe Ser Trp Val Thr Pro Cys Ile Ser
275 280 285
Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg Asp Val Asp Pro Gly Glu
290 295 300
His Tyr Ile Leu Lys Thr Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu
305 310 315 320
Val Asp Arg Leu Gly Ile Gly Lys Val Met Glu Glu Thr Leu Ser Tyr
325 330 335
Leu Leu Gly Arg Lys Lys Arg Pro Ile His Leu Ser Phe Asp Val Asp
340 345 350
Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr Gly Thr Pro Val Val Gly
355 360 365
Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile Thr Glu Glu Ile Tyr Lys
370 375 380
Thr Gly Leu Leu Ser Gly Leu Asp Ile Met Glu Val Asn Pro Ser Leu
385 390 395 400
Gly Lys Thr Pro Glu Glu Val Thr Arg Thr Val Asn Thr Ala Val Ala
405 410 415
Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg Glu Gly Asn His Lys Pro
420 425 430
Ile Asp Tyr Leu Asn Pro Pro Lys
435 440
<210> 212
<211> 1320
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 212
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc tggtggatct 360
gctaagtcta gaactattgg tattattggt gctccatttt ctaagggtca accaagaggt 420
ggtgttgaag aaggtccaac tgttttgaga aaggctggtt tgttggaaaa gttgaaggaa 480
caagaatgtg atgttaagga ttacggtgat ttgccatttg ctgatattcc aaacgattct 540
ccatttcaaa ttgttaagaa cccaagatct gttggtaagg cttctgaaca attggctggt 600
aaggttgctg aagttaagaa gaacggtaga atttctttgg ttttgggtgg tgatcattct 660
ttggctattg gttctatttc tggtcatgct agagttcatc cagatttggg tgttatttgg 720
gttgatgctc atactgatat taacactcca ttgactacta cttctggtaa cttgcatggt 780
caaccagttt cttttttgtt gaaggaattg aagggtaaga ttccagatgt tccaggtttt 840
tcttgggtta ctccatgtat ttctgctaag gatattgttt acattggttt gagagatgtt 900
gatccaggtg aacattacat tttgaagact ttgggtatta agtacttttc tatgactgaa 960
gttgatagat tgggtattgg taaggttatg gaagaaactt tgtcttactt gttgggtaga 1020
aagaagagac caattcattt gtcttttgat gttgatggtt tggatccatc ttttactcca 1080
gctactggta ctccagttgt tggtggtttg acttacagag aaggtttgta cattactgaa 1140
gaaatttaca agactggttt gttgtctggt ttggatatta tggaagttaa cccatctttg 1200
ggtaagactc cagaagaagt tactagaact gttaacactg ctgttgctat tactttggct 1260
tgttttggtt tggctagaga aggtaaccat aagccaattg attacttgaa cccaccaaag 1320
<210> 213
<211> 430
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 213
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala
20 25 30
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
35 40 45
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ser Ala Lys
100 105 110
Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro
115 120 125
Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu
130 135 140
Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp
145 150 155 160
Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys
165 170 175
Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val
180 185 190
Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp
195 200 205
His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro
210 215 220
Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro
225 230 235 240
Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu
245 250 255
Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp
260 265 270
Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg
275 280 285
Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys
290 295 300
Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met
305 310 315 320
Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His
325 330 335
Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr
340 345 350
Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile
355 360 365
Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met
370 375 380
Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr
385 390 395 400
Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg
405 410 415
Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys
420 425 430
<210> 214
<211> 1290
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 214
ggtccaccag gtgaagctgg tgctccaggt ccagaaggtg ctgaaggtga agctggtgaa 60
ccaggtccag ctggtgaacc aggtccagct ggtgctccag gtgaagctgg tccaccaggt 120
ccagctggtg ctgaaggtga agctggtcca gctggtgctc caggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 300
gctccaggtc caccaggtga agctggttct gctaagtcta gaactattgg tattattggt 360
gctccatttt ctaagggtca accaagaggt ggtgttgaag aaggtccaac tgttttgaga 420
aaggctggtt tgttggaaaa gttgaaggaa caagaatgtg atgttaagga ttacggtgat 480
ttgccatttg ctgatattcc aaacgattct ccatttcaaa ttgttaagaa cccaagatct 540
gttggtaagg cttctgaaca attggctggt aaggttgctg aagttaagaa gaacggtaga 600
atttctttgg ttttgggtgg tgatcattct ttggctattg gttctatttc tggtcatgct 660
agagttcatc cagatttggg tgttatttgg gttgatgctc atactgatat taacactcca 720
ttgactacta cttctggtaa cttgcatggt caaccagttt cttttttgtt gaaggaattg 780
aagggtaaga ttccagatgt tccaggtttt tcttgggtta ctccatgtat ttctgctaag 840
gatattgttt acattggttt gagagatgtt gatccaggtg aacattacat tttgaagact 900
ttgggtatta agtacttttc tatgactgaa gttgatagat tgggtattgg taaggttatg 960
gaagaaactt tgtcttactt gttgggtaga aagaagagac caattcattt gtcttttgat 1020
gttgatggtt tggatccatc ttttactcca gctactggta ctccagttgt tggtggtttg 1080
acttacagag aaggtttgta cattactgaa gaaatttaca agactggttt gttgtctggt 1140
ttggatatta tggaagttaa cccatctttg ggtaagactc cagaagaagt tactagaact 1200
gttaacactg ctgttgctat tactttggct tgttttggtt tggctagaga aggtaaccat 1260
aagccaattg attacttgaa cccaccaaag 1290
<210> 215
<211> 430
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 215
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
1 5 10 15
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu
20 25 30
Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro
35 40 45
Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ser Ala Lys
100 105 110
Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro
115 120 125
Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu
130 135 140
Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp
145 150 155 160
Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys
165 170 175
Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val
180 185 190
Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp
195 200 205
His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro
210 215 220
Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro
225 230 235 240
Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu
245 250 255
Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp
260 265 270
Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg
275 280 285
Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys
290 295 300
Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met
305 310 315 320
Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His
325 330 335
Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr
340 345 350
Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile
355 360 365
Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met
370 375 380
Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr
385 390 395 400
Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg
405 410 415
Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys
420 425 430
<210> 216
<211> 1290
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 216
ggtccagctg gtgctccagg tgaagctggt ccaccaggtc cagctggtgc tgaaggtgaa 60
gctggtccag ctggtgctcc aggtccacca ggtgaagctg gtgctccagg tccagaaggt 120
gctgaaggtg aagctggtga accaggtcca gctggtgaac caggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 300
gctccaggtc caccaggtga agctggttct gctaagtcta gaactattgg tattattggt 360
gctccatttt ctaagggtca accaagaggt ggtgttgaag aaggtccaac tgttttgaga 420
aaggctggtt tgttggaaaa gttgaaggaa caagaatgtg atgttaagga ttacggtgat 480
ttgccatttg ctgatattcc aaacgattct ccatttcaaa ttgttaagaa cccaagatct 540
gttggtaagg cttctgaaca attggctggt aaggttgctg aagttaagaa gaacggtaga 600
atttctttgg ttttgggtgg tgatcattct ttggctattg gttctatttc tggtcatgct 660
agagttcatc cagatttggg tgttatttgg gttgatgctc atactgatat taacactcca 720
ttgactacta cttctggtaa cttgcatggt caaccagttt cttttttgtt gaaggaattg 780
aagggtaaga ttccagatgt tccaggtttt tcttgggtta ctccatgtat ttctgctaag 840
gatattgttt acattggttt gagagatgtt gatccaggtg aacattacat tttgaagact 900
ttgggtatta agtacttttc tatgactgaa gttgatagat tgggtattgg taaggttatg 960
gaagaaactt tgtcttactt gttgggtaga aagaagagac caattcattt gtcttttgat 1020
gttgatggtt tggatccatc ttttactcca gctactggta ctccagttgt tggtggtttg 1080
acttacagag aaggtttgta cattactgaa gaaatttaca agactggttt gttgtctggt 1140
ttggatatta tggaagttaa cccatctttg ggtaagactc cagaagaagt tactagaact 1200
gttaacactg ctgttgctat tactttggct tgttttggtt tggctagaga aggtaaccat 1260
aagccaattg attacttgaa cccaccaaag 1290
<210> 217
<211> 557
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 217
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Gly Ser Ala Lys Ser Arg Thr Ile Gly Ile
115 120 125
Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro Arg Gly Gly Val Glu Glu
130 135 140
Gly Pro Thr Val Leu Arg Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu
145 150 155 160
Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile
165 170 175
Pro Asn Asp Ser Pro Phe Gln Ile Val Lys Asn Pro Arg Ser Val Gly
180 185 190
Lys Ala Ser Glu Gln Leu Ala Gly Lys Val Ala Glu Val Lys Lys Asn
195 200 205
Gly Arg Ile Ser Leu Val Leu Gly Gly Asp His Ser Leu Ala Ile Gly
210 215 220
Ser Ile Ser Gly His Ala Arg Val His Pro Asp Leu Gly Val Ile Trp
225 230 235 240
Val Asp Ala His Thr Asp Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly
245 250 255
Asn Leu His Gly Gln Pro Val Ser Phe Leu Leu Lys Glu Leu Lys Gly
260 265 270
Lys Ile Pro Asp Val Pro Gly Phe Ser Trp Val Thr Pro Cys Ile Ser
275 280 285
Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg Asp Val Asp Pro Gly Glu
290 295 300
His Tyr Ile Leu Lys Thr Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu
305 310 315 320
Val Asp Arg Leu Gly Ile Gly Lys Val Met Glu Glu Thr Leu Ser Tyr
325 330 335
Leu Leu Gly Arg Lys Lys Arg Pro Ile His Leu Ser Phe Asp Val Asp
340 345 350
Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr Gly Thr Pro Val Val Gly
355 360 365
Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile Thr Glu Glu Ile Tyr Lys
370 375 380
Thr Gly Leu Leu Ser Gly Leu Asp Ile Met Glu Val Asn Pro Ser Leu
385 390 395 400
Gly Lys Thr Pro Glu Glu Val Thr Arg Thr Val Asn Thr Ala Val Ala
405 410 415
Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg Glu Gly Asn His Lys Pro
420 425 430
Ile Asp Tyr Leu Asn Pro Pro Lys Gly Pro Pro Gly Glu Ala Gly Ala
435 440 445
Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala
450 455 460
Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly
465 470 475 480
Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro
485 490 495
Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu
500 505 510
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly
515 520 525
Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala
530 535 540
Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala
545 550 555
<210> 218
<211> 1671
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 218
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc tggtggatct 360
gctaagtcta gaactattgg tattattggt gctccatttt ctaagggtca accaagaggt 420
ggtgttgaag aaggtccaac tgttttgaga aaggctggtt tgttggaaaa gttgaaggaa 480
caagaatgtg atgttaagga ttacggtgat ttgccatttg ctgatattcc aaacgattct 540
ccatttcaaa ttgttaagaa cccaagatct gttggtaagg cttctgaaca attggctggt 600
aaggttgctg aagttaagaa gaacggtaga atttctttgg ttttgggtgg tgatcattct 660
ttggctattg gttctatttc tggtcatgct agagttcatc cagatttggg tgttatttgg 720
gttgatgctc atactgatat taacactcca ttgactacta cttctggtaa cttgcatggt 780
caaccagttt cttttttgtt gaaggaattg aagggtaaga ttccagatgt tccaggtttt 840
tcttgggtta ctccatgtat ttctgctaag gatattgttt acattggttt gagagatgtt 900
gatccaggtg aacattacat tttgaagact ttgggtatta agtacttttc tatgactgaa 960
gttgatagat tgggtattgg taaggttatg gaagaaactt tgtcttactt gttgggtaga 1020
aagaagagac caattcattt gtcttttgat gttgatggtt tggatccatc ttttactcca 1080
gctactggta ctccagttgt tggtggtttg acttacagag aaggtttgta cattactgaa 1140
gaaatttaca agactggttt gttgtctggt ttggatatta tggaagttaa cccatctttg 1200
ggtaagactc cagaagaagt tactagaact gttaacactg ctgttgctat tactttggct 1260
tgttttggtt tggctagaga aggtaaccat aagccaattg attacttgaa cccaccaaag 1320
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 1380
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 1440
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 1500
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 1560
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 1620
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc t 1671
<210> 219
<211> 538
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 219
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala
20 25 30
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
35 40 45
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ser Ala Lys
100 105 110
Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro
115 120 125
Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu
130 135 140
Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp
145 150 155 160
Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys
165 170 175
Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val
180 185 190
Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp
195 200 205
His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro
210 215 220
Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro
225 230 235 240
Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu
245 250 255
Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp
260 265 270
Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg
275 280 285
Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys
290 295 300
Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met
305 310 315 320
Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His
325 330 335
Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr
340 345 350
Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile
355 360 365
Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met
370 375 380
Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr
385 390 395 400
Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg
405 410 415
Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys Gly Pro
420 425 430
Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala
435 440 445
Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly
450 455 460
Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro
465 470 475 480
Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala
485 490 495
Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly
500 505 510
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
515 520 525
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
530 535
<210> 220
<211> 1614
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 220
ggtccaccag gtgaagctgg tgctccaggt ccagaaggtg ctgaaggtga agctggtgaa 60
ccaggtccag ctggtgaacc aggtccagct ggtgctccag gtgaagctgg tccaccaggt 120
ccagctggtg ctgaaggtga agctggtcca gctggtgctc caggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 300
gctccaggtc caccaggtga agctggttct gctaagtcta gaactattgg tattattggt 360
gctccatttt ctaagggtca accaagaggt ggtgttgaag aaggtccaac tgttttgaga 420
aaggctggtt tgttggaaaa gttgaaggaa caagaatgtg atgttaagga ttacggtgat 480
ttgccatttg ctgatattcc aaacgattct ccatttcaaa ttgttaagaa cccaagatct 540
gttggtaagg cttctgaaca attggctggt aaggttgctg aagttaagaa gaacggtaga 600
atttctttgg ttttgggtgg tgatcattct ttggctattg gttctatttc tggtcatgct 660
agagttcatc cagatttggg tgttatttgg gttgatgctc atactgatat taacactcca 720
ttgactacta cttctggtaa cttgcatggt caaccagttt cttttttgtt gaaggaattg 780
aagggtaaga ttccagatgt tccaggtttt tcttgggtta ctccatgtat ttctgctaag 840
gatattgttt acattggttt gagagatgtt gatccaggtg aacattacat tttgaagact 900
ttgggtatta agtacttttc tatgactgaa gttgatagat tgggtattgg taaggttatg 960
gaagaaactt tgtcttactt gttgggtaga aagaagagac caattcattt gtcttttgat 1020
gttgatggtt tggatccatc ttttactcca gctactggta ctccagttgt tggtggtttg 1080
acttacagag aaggtttgta cattactgaa gaaatttaca agactggttt gttgtctggt 1140
ttggatatta tggaagttaa cccatctttg ggtaagactc cagaagaagt tactagaact 1200
gttaacactg ctgttgctat tactttggct tgttttggtt tggctagaga aggtaaccat 1260
aagccaattg attacttgaa cccaccaaag ggtccaccag gtgaagctgg tgctccaggt 1320
ccagaaggtg ctgaaggtga agctggtgaa ccaggtccag ctggtgaacc aggtccagct 1380
ggtgctccag gtgaagctgg tccaccaggt ccagctggtg ctgaaggtga agctggtcca 1440
gctggtgctc caggtgaacc aggtccagaa ggtccaccag gtgaagctgg tgctccaggt 1500
ccaccaggtg ctccaggtgc tgaaggtgaa ccaggtccag aaggtgctcc aggtccacca 1560
ggtccagctg gtgaaccagg tccagctggt gctccaggtc caccaggtga agct 1614
<210> 221
<211> 538
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 221
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
1 5 10 15
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu
20 25 30
Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro
35 40 45
Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ser Ala Lys
100 105 110
Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro
115 120 125
Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu
130 135 140
Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp
145 150 155 160
Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys
165 170 175
Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val
180 185 190
Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp
195 200 205
His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro
210 215 220
Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro
225 230 235 240
Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu
245 250 255
Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp
260 265 270
Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg
275 280 285
Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys
290 295 300
Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met
305 310 315 320
Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His
325 330 335
Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr
340 345 350
Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile
355 360 365
Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met
370 375 380
Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr
385 390 395 400
Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg
405 410 415
Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys Gly Pro
420 425 430
Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu
435 440 445
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly
450 455 460
Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro
465 470 475 480
Ala Gly Glu Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala
485 490 495
Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly
500 505 510
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
515 520 525
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
530 535
<210> 222
<211> 1614
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 222
ggtccagctg gtgctccagg tgaagctggt ccaccaggtc cagctggtgc tgaaggtgaa 60
gctggtccag ctggtgctcc aggtccacca ggtgaagctg gtgctccagg tccagaaggt 120
gctgaaggtg aagctggtga accaggtcca gctggtgaac caggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 300
gctccaggtc caccaggtga agctggttct gctaagtcta gaactattgg tattattggt 360
gctccatttt ctaagggtca accaagaggt ggtgttgaag aaggtccaac tgttttgaga 420
aaggctggtt tgttggaaaa gttgaaggaa caagaatgtg atgttaagga ttacggtgat 480
ttgccatttg ctgatattcc aaacgattct ccatttcaaa ttgttaagaa cccaagatct 540
gttggtaagg cttctgaaca attggctggt aaggttgctg aagttaagaa gaacggtaga 600
atttctttgg ttttgggtgg tgatcattct ttggctattg gttctatttc tggtcatgct 660
agagttcatc cagatttggg tgttatttgg gttgatgctc atactgatat taacactcca 720
ttgactacta cttctggtaa cttgcatggt caaccagttt cttttttgtt gaaggaattg 780
aagggtaaga ttccagatgt tccaggtttt tcttgggtta ctccatgtat ttctgctaag 840
gatattgttt acattggttt gagagatgtt gatccaggtg aacattacat tttgaagact 900
ttgggtatta agtacttttc tatgactgaa gttgatagat tgggtattgg taaggttatg 960
gaagaaactt tgtcttactt gttgggtaga aagaagagac caattcattt gtcttttgat 1020
gttgatggtt tggatccatc ttttactcca gctactggta ctccagttgt tggtggtttg 1080
acttacagag aaggtttgta cattactgaa gaaatttaca agactggttt gttgtctggt 1140
ttggatatta tggaagttaa cccatctttg ggtaagactc cagaagaagt tactagaact 1200
gttaacactg ctgttgctat tactttggct tgttttggtt tggctagaga aggtaaccat 1260
aagccaattg attacttgaa cccaccaaag ggtccagctg gtgctccagg tgaagctggt 1320
ccaccaggtc cagctggtgc tgaaggtgaa gctggtccag ctggtgctcc aggtccacca 1380
ggtgaagctg gtgctccagg tccagaaggt gctgaaggtg aagctggtga accaggtcca 1440
gctggtgaac caggtgaacc aggtccagaa ggtccaccag gtgaagctgg tgctccaggt 1500
ccaccaggtg ctccaggtgc tgaaggtgaa ccaggtccag aaggtgctcc aggtccacca 1560
ggtccagctg gtgaaccagg tccagctggt gctccaggtc caccaggtga agct 1614
<210> 223
<211> 538
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 223
Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly
1 5 10 15
Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Pro
20 25 30
Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
35 40 45
Gly Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly
50 55 60
Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu
65 70 75 80
Ala Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu
85 90 95
Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Ser Ala Lys
100 105 110
Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro
115 120 125
Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu
130 135 140
Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp
145 150 155 160
Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys
165 170 175
Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val
180 185 190
Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp
195 200 205
His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro
210 215 220
Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro
225 230 235 240
Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu
245 250 255
Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp
260 265 270
Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg
275 280 285
Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys
290 295 300
Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met
305 310 315 320
Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His
325 330 335
Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr
340 345 350
Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile
355 360 365
Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met
370 375 380
Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr
385 390 395 400
Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg
405 410 415
Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys Gly Pro
420 425 430
Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala
435 440 445
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Pro Glu Gly
450 455 460
Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala
465 470 475 480
Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala
485 490 495
Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly
500 505 510
Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu
515 520 525
Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro
530 535
<210> 224
<211> 1614
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 224
ggtccagaag gtgctccagg tccaccaggt ccagctggtg aaccaggtcc agctggtgct 60
ccaggtccac caggtgaagc tggtgaacca ggtccagaag gtccaccagg tgaagctggt 120
gctccaggtc caccaggtgc tccaggtgct gaaggtgaac caggtccaga aggtgctcca 180
ggtccaccag gtccagctgg tgaaccaggt ccagctggtg ctccaggtcc accaggtgaa 240
gctggtccac caggtgaagc tggtgctcca ggtccagaag gtgctgaagg tgaagctggt 300
gaaccaggtc cagctggtga accaggttct gctaagtcta gaactattgg tattattggt 360
gctccatttt ctaagggtca accaagaggt ggtgttgaag aaggtccaac tgttttgaga 420
aaggctggtt tgttggaaaa gttgaaggaa caagaatgtg atgttaagga ttacggtgat 480
ttgccatttg ctgatattcc aaacgattct ccatttcaaa ttgttaagaa cccaagatct 540
gttggtaagg cttctgaaca attggctggt aaggttgctg aagttaagaa gaacggtaga 600
atttctttgg ttttgggtgg tgatcattct ttggctattg gttctatttc tggtcatgct 660
agagttcatc cagatttggg tgttatttgg gttgatgctc atactgatat taacactcca 720
ttgactacta cttctggtaa cttgcatggt caaccagttt cttttttgtt gaaggaattg 780
aagggtaaga ttccagatgt tccaggtttt tcttgggtta ctccatgtat ttctgctaag 840
gatattgttt acattggttt gagagatgtt gatccaggtg aacattacat tttgaagact 900
ttgggtatta agtacttttc tatgactgaa gttgatagat tgggtattgg taaggttatg 960
gaagaaactt tgtcttactt gttgggtaga aagaagagac caattcattt gtcttttgat 1020
gttgatggtt tggatccatc ttttactcca gctactggta ctccagttgt tggtggtttg 1080
acttacagag aaggtttgta cattactgaa gaaatttaca agactggttt gttgtctggt 1140
ttggatatta tggaagttaa cccatctttg ggtaagactc cagaagaagt tactagaact 1200
gttaacactg ctgttgctat tactttggct tgttttggtt tggctagaga aggtaaccat 1260
aagccaattg attacttgaa cccaccaaag ggtccagaag gtgctccagg tccaccaggt 1320
ccagctggtg aaccaggtcc agctggtgct ccaggtccac caggtgaagc tggtgaacca 1380
ggtccagaag gtccaccagg tgaagctggt gctccaggtc caccaggtgc tccaggtgct 1440
gaaggtgaac caggtccaga aggtgctcca ggtccaccag gtccagctgg tgaaccaggt 1500
ccagctggtg ctccaggtcc accaggtgaa gctggtccac caggtgaagc tggtgctcca 1560
ggtccagaag gtgctgaagg tgaagctggt gaaccaggtc cagctggtga acca 1614
<210> 225
<211> 538
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 225
Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly
1 5 10 15
Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu
20 25 30
Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala
35 40 45
Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly
50 55 60
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro
65 70 75 80
Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu
85 90 95
Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Ser Ala Lys
100 105 110
Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro
115 120 125
Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu
130 135 140
Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp
145 150 155 160
Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys
165 170 175
Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val
180 185 190
Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp
195 200 205
His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro
210 215 220
Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro
225 230 235 240
Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu
245 250 255
Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp
260 265 270
Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg
275 280 285
Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys
290 295 300
Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met
305 310 315 320
Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His
325 330 335
Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr
340 345 350
Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile
355 360 365
Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met
370 375 380
Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr
385 390 395 400
Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg
405 410 415
Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys Gly Pro
420 425 430
Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro
435 440 445
Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly
450 455 460
Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala
465 470 475 480
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
485 490 495
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
500 505 510
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
515 520 525
Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala
530 535
<210> 226
<211> 1614
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 226
ggtccagaag gtgctgaagg tgaagctggt gaaccaggtc cagctggtga accaggtcca 60
gaaggtgctc caggtccacc aggtccagct ggtgaaccag gtccagctgg tgctccaggt 120
ccaccaggtg aagctggtcc agctggtgct ccaggtgaag ctggtccacc aggtccagct 180
ggtgctgaag gtgaagctgg tccagctggt gctccaggtg aaccaggtcc agaaggtcca 240
ccaggtgaag ctggtgctcc aggtccacca ggtgctccag gtgctgaagg tgaaccaggt 300
gctccaggtg aaccaggtcc agctggttct gctaagtcta gaactattgg tattattggt 360
gctccatttt ctaagggtca accaagaggt ggtgttgaag aaggtccaac tgttttgaga 420
aaggctggtt tgttggaaaa gttgaaggaa caagaatgtg atgttaagga ttacggtgat 480
ttgccatttg ctgatattcc aaacgattct ccatttcaaa ttgttaagaa cccaagatct 540
gttggtaagg cttctgaaca attggctggt aaggttgctg aagttaagaa gaacggtaga 600
atttctttgg ttttgggtgg tgatcattct ttggctattg gttctatttc tggtcatgct 660
agagttcatc cagatttggg tgttatttgg gttgatgctc atactgatat taacactcca 720
ttgactacta cttctggtaa cttgcatggt caaccagttt cttttttgtt gaaggaattg 780
aagggtaaga ttccagatgt tccaggtttt tcttgggtta ctccatgtat ttctgctaag 840
gatattgttt acattggttt gagagatgtt gatccaggtg aacattacat tttgaagact 900
ttgggtatta agtacttttc tatgactgaa gttgatagat tgggtattgg taaggttatg 960
gaagaaactt tgtcttactt gttgggtaga aagaagagac caattcattt gtcttttgat 1020
gttgatggtt tggatccatc ttttactcca gctactggta ctccagttgt tggtggtttg 1080
acttacagag aaggtttgta cattactgaa gaaatttaca agactggttt gttgtctggt 1140
ttggatatta tggaagttaa cccatctttg ggtaagactc cagaagaagt tactagaact 1200
gttaacactg ctgttgctat tactttggct tgttttggtt tggctagaga aggtaaccat 1260
aagccaattg attacttgaa cccaccaaag ggtccagaag gtgctgaagg tgaagctggt 1320
gaaccaggtc cagctggtga accaggtcca gaaggtgctc caggtccacc aggtccagct 1380
ggtgaaccag gtccagctgg tgctccaggt ccaccaggtg aagctggtcc agctggtgct 1440
ccaggtgaag ctggtccacc aggtccagct ggtgctgaag gtgaagctgg tccagctggt 1500
gctccaggtg aaccaggtcc agaaggtcca ccaggtgaag ctggtgctcc aggtccacca 1560
ggtgctccag gtgctgaagg tgaaccaggt gctccaggtg aaccaggtcc agct 1614
<210> 227
<211> 538
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 227
Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly
1 5 10 15
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro
20 25 30
Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro
35 40 45
Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly
50 55 60
Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro
65 70 75 80
Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu
85 90 95
Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Ser Ala Lys
100 105 110
Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro
115 120 125
Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu
130 135 140
Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp
145 150 155 160
Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys
165 170 175
Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val
180 185 190
Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp
195 200 205
His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro
210 215 220
Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro
225 230 235 240
Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu
245 250 255
Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp
260 265 270
Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg
275 280 285
Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys
290 295 300
Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met
305 310 315 320
Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His
325 330 335
Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr
340 345 350
Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile
355 360 365
Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met
370 375 380
Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr
385 390 395 400
Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg
405 410 415
Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys Gly Pro
420 425 430
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
435 440 445
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
450 455 460
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
465 470 475 480
Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro
485 490 495
Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly
500 505 510
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
515 520 525
Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala
530 535
<210> 228
<211> 1614
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 228
ggtccagctg gtgaaccagg tccagctggt gctccaggtc caccaggtga agctggtcca 60
gctggtgctc caggtgaagc tggtccacca ggtccagctg gtgctgaagg tgaagctggt 120
ccagctggtg ctccaggtga accaggtcca gaaggtccac caggtccaga aggtgctgaa 180
ggtgaagctg gtgaaccagg tccagctggt gaaccaggtc cagaaggtgc tccaggtcca 240
ccaggtgaag ctggtgctcc aggtccacca ggtgctccag gtgctgaagg tgaaccaggt 300
gctccaggtg aaccaggtcc agctggttct gctaagtcta gaactattgg tattattggt 360
gctccatttt ctaagggtca accaagaggt ggtgttgaag aaggtccaac tgttttgaga 420
aaggctggtt tgttggaaaa gttgaaggaa caagaatgtg atgttaagga ttacggtgat 480
ttgccatttg ctgatattcc aaacgattct ccatttcaaa ttgttaagaa cccaagatct 540
gttggtaagg cttctgaaca attggctggt aaggttgctg aagttaagaa gaacggtaga 600
atttctttgg ttttgggtgg tgatcattct ttggctattg gttctatttc tggtcatgct 660
agagttcatc cagatttggg tgttatttgg gttgatgctc atactgatat taacactcca 720
ttgactacta cttctggtaa cttgcatggt caaccagttt cttttttgtt gaaggaattg 780
aagggtaaga ttccagatgt tccaggtttt tcttgggtta ctccatgtat ttctgctaag 840
gatattgttt acattggttt gagagatgtt gatccaggtg aacattacat tttgaagact 900
ttgggtatta agtacttttc tatgactgaa gttgatagat tgggtattgg taaggttatg 960
gaagaaactt tgtcttactt gttgggtaga aagaagagac caattcattt gtcttttgat 1020
gttgatggtt tggatccatc ttttactcca gctactggta ctccagttgt tggtggtttg 1080
acttacagag aaggtttgta cattactgaa gaaatttaca agactggttt gttgtctggt 1140
ttggatatta tggaagttaa cccatctttg ggtaagactc cagaagaagt tactagaact 1200
gttaacactg ctgttgctat tactttggct tgttttggtt tggctagaga aggtaaccat 1260
aagccaattg attacttgaa cccaccaaag ggtccagctg gtgaaccagg tccagctggt 1320
gctccaggtc caccaggtga agctggtcca gctggtgctc caggtgaagc tggtccacca 1380
ggtccagctg gtgctgaagg tgaagctggt ccagctggtg ctccaggtga accaggtcca 1440
gaaggtccac caggtccaga aggtgctgaa ggtgaagctg gtgaaccagg tccagctggt 1500
gaaccaggtc cagaaggtgc tccaggtcca ccaggtgaag ctggtgctcc aggtccacca 1560
ggtgctccag gtgctgaagg tgaaccaggt gctccaggtg aaccaggtcc agct 1614
<210> 229
<211> 538
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 229
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
1 5 10 15
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala
20 25 30
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
35 40 45
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly
50 55 60
Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro
65 70 75 80
Ala Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro
85 90 95
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Ser Ala Lys
100 105 110
Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro
115 120 125
Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu
130 135 140
Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp
145 150 155 160
Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys
165 170 175
Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val
180 185 190
Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp
195 200 205
His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro
210 215 220
Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro
225 230 235 240
Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu
245 250 255
Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp
260 265 270
Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg
275 280 285
Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys
290 295 300
Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met
305 310 315 320
Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His
325 330 335
Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr
340 345 350
Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile
355 360 365
Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met
370 375 380
Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr
385 390 395 400
Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg
405 410 415
Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys Gly Pro
420 425 430
Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro
435 440 445
Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu Gly
450 455 460
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
465 470 475 480
Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
485 490 495
Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly
500 505 510
Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu
515 520 525
Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala
530 535
<210> 230
<211> 1614
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 230
ggtccaccag gtccagctgg tgctgaaggt gaagctggtc cagctggtgc tccaggtgaa 60
ccaggtccag aaggtccacc aggtccagaa ggtgctgaag gtgaagctgg tgaaccaggt 120
ccagctggtg aaccaggtcc agaaggtgct ccaggtccac caggtgaagc tggtgctcca 180
ggtccaccag gtgctccagg tgctgaaggt gaaccaggtg ctccaggtga accaggtcca 240
gctggtccag ctggtgaacc aggtccagct ggtgctccag gtccaccagg tgaagctggt 300
ccagctggtg ctccaggtga agctggttct gctaagtcta gaactattgg tattattggt 360
gctccatttt ctaagggtca accaagaggt ggtgttgaag aaggtccaac tgttttgaga 420
aaggctggtt tgttggaaaa gttgaaggaa caagaatgtg atgttaagga ttacggtgat 480
ttgccatttg ctgatattcc aaacgattct ccatttcaaa ttgttaagaa cccaagatct 540
gttggtaagg cttctgaaca attggctggt aaggttgctg aagttaagaa gaacggtaga 600
atttctttgg ttttgggtgg tgatcattct ttggctattg gttctatttc tggtcatgct 660
agagttcatc cagatttggg tgttatttgg gttgatgctc atactgatat taacactcca 720
ttgactacta cttctggtaa cttgcatggt caaccagttt cttttttgtt gaaggaattg 780
aagggtaaga ttccagatgt tccaggtttt tcttgggtta ctccatgtat ttctgctaag 840
gatattgttt acattggttt gagagatgtt gatccaggtg aacattacat tttgaagact 900
ttgggtatta agtacttttc tatgactgaa gttgatagat tgggtattgg taaggttatg 960
gaagaaactt tgtcttactt gttgggtaga aagaagagac caattcattt gtcttttgat 1020
gttgatggtt tggatccatc ttttactcca gctactggta ctccagttgt tggtggtttg 1080
acttacagag aaggtttgta cattactgaa gaaatttaca agactggttt gttgtctggt 1140
ttggatatta tggaagttaa cccatctttg ggtaagactc cagaagaagt tactagaact 1200
gttaacactg ctgttgctat tactttggct tgttttggtt tggctagaga aggtaaccat 1260
aagccaattg attacttgaa cccaccaaag ggtccaccag gtccagctgg tgctgaaggt 1320
gaagctggtc cagctggtgc tccaggtgaa ccaggtccag aaggtccacc aggtccagaa 1380
ggtgctgaag gtgaagctgg tgaaccaggt ccagctggtg aaccaggtcc agaaggtgct 1440
ccaggtccac caggtgaagc tggtgctcca ggtccaccag gtgctccagg tgctgaaggt 1500
gaaccaggtg ctccaggtga accaggtcca gctggtccag ctggtgaacc aggtccagct 1560
ggtgctccag gtccaccagg tgaagctggt ccagctggtg ctccaggtga agct 1614
<210> 231
<211> 554
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 231
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
130 135 140
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
165 170 175
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
180 185 190
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
210 215 220
Pro Gly Glu Pro Gly Pro Ala Gly Gly Ser Ala Lys Ser Arg Thr Ile
225 230 235 240
Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro Arg Gly Gly Val
245 250 255
Glu Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu Leu Glu Lys Leu
260 265 270
Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp Leu Pro Phe Ala
275 280 285
Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys Asn Pro Arg Ser
290 295 300
Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val Ala Glu Val Lys
305 310 315 320
Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp His Ser Leu Ala
325 330 335
Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro Asp Leu Gly Val
340 345 350
Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro Leu Thr Thr Thr
355 360 365
Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu Leu Lys Glu Leu
370 375 380
Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp Val Thr Pro Cys
385 390 395 400
Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg Asp Val Asp Pro
405 410 415
Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys Tyr Phe Ser Met
420 425 430
Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met Glu Glu Thr Leu
435 440 445
Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His Leu Ser Phe Asp
450 455 460
Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr Gly Thr Pro Val
465 470 475 480
Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile Thr Glu Glu Ile
485 490 495
Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met Glu Val Asn Pro
500 505 510
Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr Val Asn Thr Ala
515 520 525
Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg Glu Gly Asn His
530 535 540
Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys
545 550
<210> 232
<211> 1662
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 232
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc tggtgaagct 360
ggtgcacccg gacccgaagg tgccgaagga gaggctggtg aacctggacc cgccggtgaa 420
ccaggacctg aaggagctcc aggtcctcct ggacccgcag gagagcccgg tcctgccggt 480
gctcctggtc cacccggaga agcaggtcca gccggagctc ctggtgaggc tggtccccca 540
ggacccgctg gagctgaagg tgaggcaggt ccagccggcg ctccaggtga gccaggacca 600
gaaggtccac caggagaagc tggagcaccc ggtcctccag gagcacccgg cgctgaagga 660
gaacccggtg ctcctggaga acccggtcca gctggtggat ctgctaagtc tagaactatt 720
ggtattattg gtgctccatt ttctaagggt caaccaagag gtggtgttga agaaggtcca 780
actgttttga gaaaggctgg tttgttggaa aagttgaagg aacaagaatg tgatgttaag 840
gattacggtg atttgccatt tgctgatatt ccaaacgatt ctccatttca aattgttaag 900
aacccaagat ctgttggtaa ggcttctgaa caattggctg gtaaggttgc tgaagttaag 960
aagaacggta gaatttcttt ggttttgggt ggtgatcatt ctttggctat tggttctatt 1020
tctggtcatg ctagagttca tccagatttg ggtgttattt gggttgatgc tcatactgat 1080
attaacactc cattgactac tacttctggt aacttgcatg gtcaaccagt ttcttttttg 1140
ttgaaggaat tgaagggtaa gattccagat gttccaggtt tttcttgggt tactccatgt 1200
atttctgcta aggatattgt ttacattggt ttgagagatg ttgatccagg tgaacattac 1260
attttgaaga ctttgggtat taagtacttt tctatgactg aagttgatag attgggtatt 1320
ggtaaggtta tggaagaaac tttgtcttac ttgttgggta gaaagaagag accaattcat 1380
ttgtcttttg atgttgatgg tttggatcca tcttttactc cagctactgg tactccagtt 1440
gttggtggtt tgacttacag agaaggtttg tacattactg aagaaattta caagactggt 1500
ttgttgtctg gtttggatat tatggaagtt aacccatctt tgggtaagac tccagaagaa 1560
gttactagaa ctgttaacac tgctgttgct attactttgg cttgttttgg tttggctaga 1620
gaaggtaacc ataagccaat tgattacttg aacccaccaa ag 1662
<210> 233
<211> 785
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 233
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
130 135 140
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
165 170 175
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
180 185 190
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
210 215 220
Pro Gly Glu Pro Gly Pro Ala Gly Gly Ser Ala Lys Ser Arg Thr Ile
225 230 235 240
Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro Arg Gly Gly Val
245 250 255
Glu Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu Leu Glu Lys Leu
260 265 270
Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp Leu Pro Phe Ala
275 280 285
Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys Asn Pro Arg Ser
290 295 300
Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val Ala Glu Val Lys
305 310 315 320
Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp His Ser Leu Ala
325 330 335
Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro Asp Leu Gly Val
340 345 350
Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro Leu Thr Thr Thr
355 360 365
Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu Leu Lys Glu Leu
370 375 380
Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp Val Thr Pro Cys
385 390 395 400
Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg Asp Val Asp Pro
405 410 415
Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys Tyr Phe Ser Met
420 425 430
Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met Glu Glu Thr Leu
435 440 445
Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His Leu Ser Phe Asp
450 455 460
Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr Gly Thr Pro Val
465 470 475 480
Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile Thr Glu Glu Ile
485 490 495
Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met Glu Val Asn Pro
500 505 510
Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr Val Asn Thr Ala
515 520 525
Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg Glu Gly Asn His
530 535 540
Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys Gly Pro Pro Gly Glu Ala
545 550 555 560
Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly
565 570 575
Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
580 585 590
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
595 600 605
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
610 615 620
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
625 630 635 640
Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
645 650 655
Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly
660 665 670
Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu
675 680 685
Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro
690 695 700
Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly
705 710 715 720
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro
725 730 735
Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro
740 745 750
Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly
755 760 765
Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro
770 775 780
Ala
785
<210> 234
<211> 2355
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 234
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc tggtgaagct 360
ggtgcacccg gacccgaagg tgccgaagga gaggctggtg aacctggacc cgccggtgaa 420
ccaggacctg aaggagctcc aggtcctcct ggacccgcag gagagcccgg tcctgccggt 480
gctcctggtc cacccggaga agcaggtcca gccggagctc ctggtgaggc tggtccccca 540
ggacccgctg gagctgaagg tgaggcaggt ccagccggcg ctccaggtga gccaggacca 600
gaaggtccac caggagaagc tggagcaccc ggtcctccag gagcacccgg cgctgaagga 660
gaacccggtg ctcctggaga acccggtcca gctggtggat ctgctaagtc tagaactatt 720
ggtattattg gtgctccatt ttctaagggt caaccaagag gtggtgttga agaaggtcca 780
actgttttga gaaaggctgg tttgttggaa aagttgaagg aacaagaatg tgatgttaag 840
gattacggtg atttgccatt tgctgatatt ccaaacgatt ctccatttca aattgttaag 900
aacccaagat ctgttggtaa ggcttctgaa caattggctg gtaaggttgc tgaagttaag 960
aagaacggta gaatttcttt ggttttgggt ggtgatcatt ctttggctat tggttctatt 1020
tctggtcatg ctagagttca tccagatttg ggtgttattt gggttgatgc tcatactgat 1080
attaacactc cattgactac tacttctggt aacttgcatg gtcaaccagt ttcttttttg 1140
ttgaaggaat tgaagggtaa gattccagat gttccaggtt tttcttgggt tactccatgt 1200
atttctgcta aggatattgt ttacattggt ttgagagatg ttgatccagg tgaacattac 1260
attttgaaga ctttgggtat taagtacttt tctatgactg aagttgatag attgggtatt 1320
ggtaaggtta tggaagaaac tttgtcttac ttgttgggta gaaagaagag accaattcat 1380
ttgtcttttg atgttgatgg tttggatcca tcttttactc cagctactgg tactccagtt 1440
gttggtggtt tgacttacag agaaggtttg tacattactg aagaaattta caagactggt 1500
ttgttgtctg gtttggatat tatggaagtt aacccatctt tgggtaagac tccagaagaa 1560
gttactagaa ctgttaacac tgctgttgct attactttgg cttgttttgg tttggctaga 1620
gaaggtaacc ataagccaat tgattacttg aacccaccaa agggtccacc tggtgaagct 1680
ggtgcacccg gacccgaagg tgccgaagga gaggctggtg aacctggacc cgccggtgaa 1740
ccaggacctg aaggagctcc aggtcctcct ggacccgcag gagagcccgg tcctgccggt 1800
gctcctggtc cacccggaga agcaggtcca gccggagctc ctggtgaggc tggtccccca 1860
ggacccgctg gagctgaagg tgaggcaggt ccagccggcg ctccaggtga gccaggacca 1920
gaaggtccac caggagaagc tggagcaccc ggtcctccag gagcacccgg cgctgaagga 1980
gaacccggtg ctcctggaga acccggtcca gctggtgaag ctggtgcacc cggacccgaa 2040
ggtgccgaag gagaggctgg tgaacctgga cccgccggtg aaccaggacc tgaaggagct 2100
ccaggtcctc ctggacccgc aggagagccc ggtcctgccg gtgctcctgg tccacccgga 2160
gaagcaggtc cagccggagc tcctggtgag gctggtcccc caggacccgc tggagctgaa 2220
ggtgaggcag gtccagccgg cgctccaggt gagccaggac cagaaggtcc accaggagaa 2280
gctggagcac ccggtcctcc aggagcaccc ggcgctgaag gagaacccgg tgctcctgga 2340
gaacccggtc cagct 2355
<210> 235
<211> 1241
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 235
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
130 135 140
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
165 170 175
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
180 185 190
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
210 215 220
Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu
225 230 235 240
Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly
245 250 255
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
260 265 270
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro
275 280 285
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
290 295 300
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu
305 310 315 320
Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro
325 330 335
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly
340 345 350
Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu
355 360 365
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
370 375 380
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly
385 390 395 400
Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu
405 410 415
Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro
420 425 430
Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly
435 440 445
Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Gly Ser Ala Lys
450 455 460
Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro
465 470 475 480
Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu
485 490 495
Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp
500 505 510
Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys
515 520 525
Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val
530 535 540
Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp
545 550 555 560
His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro
565 570 575
Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro
580 585 590
Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu
595 600 605
Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp
610 615 620
Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg
625 630 635 640
Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys
645 650 655
Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met
660 665 670
Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His
675 680 685
Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr
690 695 700
Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile
705 710 715 720
Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met
725 730 735
Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr
740 745 750
Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg
755 760 765
Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys Gly Pro
770 775 780
Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala
785 790 795 800
Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly
805 810 815
Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro
820 825 830
Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro
835 840 845
Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly
850 855 860
Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro
865 870 875 880
Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro
885 890 895
Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
900 905 910
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
915 920 925
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
930 935 940
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
945 950 955 960
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
965 970 975
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
980 985 990
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
995 1000 1005
Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
1010 1015 1020
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
1025 1030 1035 1040
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
1045 1050 1055
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
1060 1065 1070
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
1075 1080 1085
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
1090 1095 1100
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
1105 1110 1115 1120
Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu
1125 1130 1135
Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly
1140 1145 1150
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
1155 1160 1165
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro
1170 1175 1180
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
1185 1190 1195 1200
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu
1205 1210 1215
Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro
1220 1225 1230
Gly Ala Pro Gly Glu Pro Gly Pro Ala
1235 1240
<210> 236
<211> 3723
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 236
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc tggtgaagct 360
ggtgcacccg gacccgaagg tgccgaagga gaggctggtg aacctggacc cgccggtgaa 420
ccaggacctg aaggagctcc aggtcctcct ggacccgcag gagagcccgg tcctgccggt 480
gctcctggtc cacccggaga agcaggtcca gccggagctc ctggtgaggc tggtccccca 540
ggacccgctg gagctgaagg tgaggcaggt ccagccggcg ctccaggtga gccaggacca 600
gaaggtccac caggagaagc tggagcaccc ggtcctccag gagcacccgg cgctgaagga 660
gaacccggtg ctcctggaga acccggtcca gctggtgaag ctggtgcacc cggacccgaa 720
ggtgccgaag gagaggctgg tgaacctgga cccgccggtg aaccaggacc tgaaggagct 780
ccaggtcctc ctggacccgc aggagagccc ggtcctgccg gtgctcctgg tccacccgga 840
gaagcaggtc cagccggagc tcctggtgag gctggtcccc caggacccgc tggagctgaa 900
ggtgaggcag gtccagccgg cgctccaggt gagccaggac cagaaggtcc accaggagaa 960
gctggagcac ccggtcctcc aggagcaccc ggcgctgaag gagaacccgg tgctcctgga 1020
gaacccggtc cagctggtga agctggtgca cccggacccg aaggtgccga aggagaggct 1080
ggtgaacctg gacccgccgg tgaaccagga cctgaaggag ctccaggtcc tcctggaccc 1140
gcaggagagc ccggtcctgc cggtgctcct ggtccacccg gagaagcagg tccagccgga 1200
gctcctggtg aggctggtcc cccaggaccc gctggagctg aaggtgaggc aggtccagcc 1260
ggcgctccag gtgagccagg accagaaggt ccaccaggag aagctggagc acccggtcct 1320
ccaggagcac ccggcgctga aggagaaccc ggtgctcctg gagaacccgg tccagctggt 1380
ggatctgcta agtctagaac tattggtatt attggtgctc cattttctaa gggtcaacca 1440
agaggtggtg ttgaagaagg tccaactgtt ttgagaaagg ctggtttgtt ggaaaagttg 1500
aaggaacaag aatgtgatgt taaggattac ggtgatttgc catttgctga tattccaaac 1560
gattctccat ttcaaattgt taagaaccca agatctgttg gtaaggcttc tgaacaattg 1620
gctggtaagg ttgctgaagt taagaagaac ggtagaattt ctttggtttt gggtggtgat 1680
cattctttgg ctattggttc tatttctggt catgctagag ttcatccaga tttgggtgtt 1740
atttgggttg atgctcatac tgatattaac actccattga ctactacttc tggtaacttg 1800
catggtcaac cagtttcttt tttgttgaag gaattgaagg gtaagattcc agatgttcca 1860
ggtttttctt gggttactcc atgtatttct gctaaggata ttgtttacat tggtttgaga 1920
gatgttgatc caggtgaaca ttacattttg aagactttgg gtattaagta cttttctatg 1980
actgaagttg atagattggg tattggtaag gttatggaag aaactttgtc ttacttgttg 2040
ggtagaaaga agagaccaat tcatttgtct tttgatgttg atggtttgga tccatctttt 2100
actccagcta ctggtactcc agttgttggt ggtttgactt acagagaagg tttgtacatt 2160
actgaagaaa tttacaagac tggtttgttg tctggtttgg atattatgga agttaaccca 2220
tctttgggta agactccaga agaagttact agaactgtta acactgctgt tgctattact 2280
ttggcttgtt ttggtttggc tagagaaggt aaccataagc caattgatta cttgaaccca 2340
ccaaagggtc cacctggtga agctggtgca cccggacccg aaggtgccga aggagaggct 2400
ggtgaacctg gacccgccgg tgaaccagga cctgaaggag ctccaggtcc tcctggaccc 2460
gcaggagagc ccggtcctgc cggtgctcct ggtccacccg gagaagcagg tccagccgga 2520
gctcctggtg aggctggtcc cccaggaccc gctggagctg aaggtgaggc aggtccagcc 2580
ggcgctccag gtgagccagg accagaaggt ccaccaggag aagctggagc acccggtcct 2640
ccaggagcac ccggcgctga aggagaaccc ggtgctcctg gagaacccgg tccagctggt 2700
gaagctggtg cacccggacc cgaaggtgcc gaaggagagg ctggtgaacc tggacccgcc 2760
ggtgaaccag gacctgaagg agctccaggt cctcctggac ccgcaggaga gcccggtcct 2820
gccggtgctc ctggtccacc cggagaagca ggtccagccg gagctcctgg tgaggctggt 2880
cccccaggac ccgctggagc tgaaggtgag gcaggtccag ccggcgctcc aggtgagcca 2940
ggaccagaag gtccaccagg agaagctgga gcacccggtc ctccaggagc acccggcgct 3000
gaaggagaac ccggtgctcc tggagaaccc ggtccagctg gtgaagctgg tgcacccgga 3060
cccgaaggtg ccgaaggaga ggctggtgaa cctggacccg ccggtgaacc aggacctgaa 3120
ggagctccag gtcctcctgg acccgcagga gagcccggtc ctgccggtgc tcctggtcca 3180
cccggagaag caggtccagc cggagctcct ggtgaggctg gtcccccagg acccgctgga 3240
gctgaaggtg aggcaggtcc agccggcgct ccaggtgagc caggaccaga aggtccacca 3300
ggagaagctg gagcacccgg tcctccagga gcacccggcg ctgaaggaga acccggtgct 3360
cctggagaac ccggtccagc tggtgaagct ggtgcacccg gacccgaagg tgccgaagga 3420
gaggctggtg aacctggacc cgccggtgaa ccaggacctg aaggagctcc aggtcctcct 3480
ggacccgcag gagagcccgg tcctgccggt gctcctggtc cacccggaga agcaggtcca 3540
gccggagctc ctggtgaggc tggtccccca ggacccgctg gagctgaagg tgaggcaggt 3600
ccagccggcg ctccaggtga gccaggacca gaaggtccac caggagaagc tggagcaccc 3660
ggtcctccag gagcacccgg cgctgaagga gaacccggtg ctcctggaga acccggtcca 3720
gct 3723
<210> 237
<211> 1186
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 237
Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly
1 5 10 15
Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu
20 25 30
Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala
35 40 45
Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly
50 55 60
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro
65 70 75 80
Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu
85 90 95
Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Glu Gly
100 105 110
Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro
115 120 125
Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala
130 135 140
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly
145 150 155 160
Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro
165 170 175
Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala
180 185 190
Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly
195 200 205
Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Glu Gly Ala Glu Gly Glu
210 215 220
Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro
225 230 235 240
Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly
245 250 255
Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro
260 265 270
Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro
275 280 285
Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly
290 295 300
Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu
305 310 315 320
Pro Gly Pro Ala Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro
325 330 335
Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly
340 345 350
Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu
355 360 365
Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala
370 375 380
Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly
385 390 395 400
Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala
405 410 415
Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala
420 425 430
Gly Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser
435 440 445
Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg
450 455 460
Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys
465 470 475 480
Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe
485 490 495
Gln Ile Val Lys Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu
500 505 510
Ala Gly Lys Val Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val
515 520 525
Leu Gly Gly Asp His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala
530 535 540
Arg Val His Pro Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp
545 550 555 560
Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro
565 570 575
Val Ser Phe Leu Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro
580 585 590
Gly Phe Ser Trp Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr
595 600 605
Ile Gly Leu Arg Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr
610 615 620
Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile
625 630 635 640
Gly Lys Val Met Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys
645 650 655
Arg Pro Ile His Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe
660 665 670
Thr Pro Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu
675 680 685
Gly Leu Tyr Ile Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly
690 695 700
Leu Asp Ile Met Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu
705 710 715 720
Val Thr Arg Thr Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe
725 730 735
Gly Leu Ala Arg Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro
740 745 750
Pro Lys Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro
755 760 765
Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala
770 775 780
Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly
785 790 795 800
Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala
805 810 815
Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu
820 825 830
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly
835 840 845
Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro
850 855 860
Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro
865 870 875 880
Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly
885 890 895
Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala
900 905 910
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
915 920 925
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
930 935 940
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
945 950 955 960
Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Glu Gly Ala Glu
965 970 975
Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly
980 985 990
Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala
995 1000 1005
Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala
1010 1015 1020
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
1025 1030 1035 1040
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala
1045 1050 1055
Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro
1060 1065 1070
Gly Glu Pro Gly Pro Ala Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly
1075 1080 1085
Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro
1090 1095 1100
Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro
1105 1110 1115 1120
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly
1125 1130 1135
Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
1140 1145 1150
Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro
1155 1160 1165
Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly
1170 1175 1180
Pro Ala
1185
<210> 238
<211> 3558
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 238
ggtccagaag gtgctgaagg tgaagctggt gaaccaggtc cagctggtga accaggtcca 60
gaaggtgctc caggtccacc aggtccagct ggtgaaccag gtccagctgg tgctccaggt 120
ccaccaggtg aagctggtcc agctggtgct ccaggtgaag ctggtccacc aggtccagct 180
ggtgctgaag gtgaagctgg tccagctggt gctccaggtg aaccaggtcc agaaggtcca 240
ccaggtgaag ctggtgctcc aggtccacca ggtgctccag gtgctgaagg tgaaccaggt 300
gctccaggtg aaccaggtcc agctggtcca gaaggtgctg aaggtgaagc tggtgaacca 360
ggtccagctg gtgaaccagg tccagaaggt gctccaggtc caccaggtcc agctggtgaa 420
ccaggtccag ctggtgctcc aggtccacca ggtgaagctg gtccagctgg tgctccaggt 480
gaagctggtc caccaggtcc agctggtgct gaaggtgaag ctggtccagc tggtgctcca 540
ggtgaaccag gtccagaagg tccaccaggt gaagctggtg ctccaggtcc accaggtgct 600
ccaggtgctg aaggtgaacc aggtgctcca ggtgaaccag gtccagctgg tccagaaggt 660
gctgaaggtg aagctggtga accaggtcca gctggtgaac caggtccaga aggtgctcca 720
ggtccaccag gtccagctgg tgaaccaggt ccagctggtg ctccaggtcc accaggtgaa 780
gctggtccag ctggtgctcc aggtgaagct ggtccaccag gtccagctgg tgctgaaggt 840
gaagctggtc cagctggtgc tccaggtgaa ccaggtccag aaggtccacc aggtgaagct 900
ggtgctccag gtccaccagg tgctccaggt gctgaaggtg aaccaggtgc tccaggtgaa 960
ccaggtccag ctggtccaga aggtgctgaa ggtgaagctg gtgaaccagg tccagctggt 1020
gaaccaggtc cagaaggtgc tccaggtcca ccaggtccag ctggtgaacc aggtccagct 1080
ggtgctccag gtccaccagg tgaagctggt ccagctggtg ctccaggtga agctggtcca 1140
ccaggtccag ctggtgctga aggtgaagct ggtccagctg gtgctccagg tgaaccaggt 1200
ccagaaggtc caccaggtga agctggtgct ccaggtccac caggtgctcc aggtgctgaa 1260
ggtgaaccag gtgctccagg tgaaccaggt ccagctggtt ctgctaagtc tagaactatt 1320
ggtattattg gtgctccatt ttctaagggt caaccaagag gtggtgttga agaaggtcca 1380
actgttttga gaaaggctgg tttgttggaa aagttgaagg aacaagaatg tgatgttaag 1440
gattacggtg atttgccatt tgctgatatt ccaaacgatt ctccatttca aattgttaag 1500
aacccaagat ctgttggtaa ggcttctgaa caattggctg gtaaggttgc tgaagttaag 1560
aagaacggta gaatttcttt ggttttgggt ggtgatcatt ctttggctat tggttctatt 1620
tctggtcatg ctagagttca tccagatttg ggtgttattt gggttgatgc tcatactgat 1680
attaacactc cattgactac tacttctggt aacttgcatg gtcaaccagt ttcttttttg 1740
ttgaaggaat tgaagggtaa gattccagat gttccaggtt tttcttgggt tactccatgt 1800
atttctgcta aggatattgt ttacattggt ttgagagatg ttgatccagg tgaacattac 1860
attttgaaga ctttgggtat taagtacttt tctatgactg aagttgatag attgggtatt 1920
ggtaaggtta tggaagaaac tttgtcttac ttgttgggta gaaagaagag accaattcat 1980
ttgtcttttg atgttgatgg tttggatcca tcttttactc cagctactgg tactccagtt 2040
gttggtggtt tgacttacag agaaggtttg tacattactg aagaaattta caagactggt 2100
ttgttgtctg gtttggatat tatggaagtt aacccatctt tgggtaagac tccagaagaa 2160
gttactagaa ctgttaacac tgctgttgct attactttgg cttgttttgg tttggctaga 2220
gaaggtaacc ataagccaat tgattacttg aacccaccaa agggtccaga aggtgctgaa 2280
ggtgaagctg gtgaaccagg tccagctggt gaaccaggtc cagaaggtgc tccaggtcca 2340
ccaggtccag ctggtgaacc aggtccagct ggtgctccag gtccaccagg tgaagctggt 2400
ccagctggtg ctccaggtga agctggtcca ccaggtccag ctggtgctga aggtgaagct 2460
ggtccagctg gtgctccagg tgaaccaggt ccagaaggtc caccaggtga agctggtgct 2520
ccaggtccac caggtgctcc aggtgctgaa ggtgaaccag gtgctccagg tgaaccaggt 2580
ccagctggtc cagaaggtgc tgaaggtgaa gctggtgaac caggtccagc tggtgaacca 2640
ggtccagaag gtgctccagg tccaccaggt ccagctggtg aaccaggtcc agctggtgct 2700
ccaggtccac caggtgaagc tggtccagct ggtgctccag gtgaagctgg tccaccaggt 2760
ccagctggtg ctgaaggtga agctggtcca gctggtgctc caggtgaacc aggtccagaa 2820
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 2880
ccaggtgctc caggtgaacc aggtccagct ggtccagaag gtgctgaagg tgaagctggt 2940
gaaccaggtc cagctggtga accaggtcca gaaggtgctc caggtccacc aggtccagct 3000
ggtgaaccag gtccagctgg tgctccaggt ccaccaggtg aagctggtcc agctggtgct 3060
ccaggtgaag ctggtccacc aggtccagct ggtgctgaag gtgaagctgg tccagctggt 3120
gctccaggtg aaccaggtcc agaaggtcca ccaggtgaag ctggtgctcc aggtccacca 3180
ggtgctccag gtgctgaagg tgaaccaggt gctccaggtg aaccaggtcc agctggtcca 3240
gaaggtgctg aaggtgaagc tggtgaacca ggtccagctg gtgaaccagg tccagaaggt 3300
gctccaggtc caccaggtcc agctggtgaa ccaggtccag ctggtgctcc aggtccacca 3360
ggtgaagctg gtccagctgg tgctccaggt gaagctggtc caccaggtcc agctggtgct 3420
gaaggtgaag ctggtccagc tggtgctcca ggtgaaccag gtccagaagg tccaccaggt 3480
gaagctggtg ctccaggtcc accaggtgct ccaggtgctg aaggtgaacc aggtgctcca 3540
ggtgaaccag gtccagct 3558
<210> 239
<211> 896
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 239
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
130 135 140
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
165 170 175
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
180 185 190
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
210 215 220
Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu
225 230 235 240
Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly
245 250 255
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
260 265 270
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro
275 280 285
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
290 295 300
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu
305 310 315 320
Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro
325 330 335
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly
340 345 350
Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu
355 360 365
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
370 375 380
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly
385 390 395 400
Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu
405 410 415
Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro
420 425 430
Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly
435 440 445
Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala
450 455 460
Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala
465 470 475 480
Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly
485 490 495
Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro
500 505 510
Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu
515 520 525
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly
530 535 540
Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala
545 550 555 560
Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Gly Ser
565 570 575
Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly
580 585 590
Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg Lys Ala
595 600 605
Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr
610 615 620
Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile
625 630 635 640
Val Lys Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu Ala Gly
645 650 655
Lys Val Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val Leu Gly
660 665 670
Gly Asp His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala Arg Val
675 680 685
His Pro Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp Ile Asn
690 695 700
Thr Pro Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro Val Ser
705 710 715 720
Phe Leu Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro Gly Phe
725 730 735
Ser Trp Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly
740 745 750
Leu Arg Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr Leu Gly
755 760 765
Ile Lys Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly Lys
770 775 780
Val Met Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro
785 790 795 800
Ile His Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr Pro
805 810 815
Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu
820 825 830
Tyr Ile Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp
835 840 845
Ile Met Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val Thr
850 855 860
Arg Thr Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu
865 870 875 880
Ala Arg Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys
885 890 895
<210> 240
<211> 2688
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 240
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc tggtgaagct 360
ggtgcacccg gacccgaagg tgccgaagga gaggctggtg aacctggacc cgccggtgaa 420
ccaggacctg aaggagctcc aggtcctcct ggacccgcag gagagcccgg tcctgccggt 480
gctcctggtc cacccggaga agcaggtcca gccggagctc ctggtgaggc tggtccccca 540
ggacccgctg gagctgaagg tgaggcaggt ccagccggcg ctccaggtga gccaggacca 600
gaaggtccac caggagaagc tggagcaccc ggtcctccag gagcacccgg cgctgaagga 660
gaacccggtg ctcctggaga acccggtcca gctggtgaag ctggtgcacc cggacccgaa 720
ggtgccgaag gagaggctgg tgaacctgga cccgccggtg aaccaggacc tgaaggagct 780
ccaggtcctc ctggacccgc aggagagccc ggtcctgccg gtgctcctgg tccacccgga 840
gaagcaggtc cagccggagc tcctggtgag gctggtcccc caggacccgc tggagctgaa 900
ggtgaggcag gtccagccgg cgctccaggt gagccaggac cagaaggtcc accaggagaa 960
gctggagcac ccggtcctcc aggagcaccc ggcgctgaag gagaacccgg tgctcctgga 1020
gaacccggtc cagctggtga agctggtgca cccggacccg aaggtgccga aggagaggct 1080
ggtgaacctg gacccgccgg tgaaccagga cctgaaggag ctccaggtcc tcctggaccc 1140
gcaggagagc ccggtcctgc cggtgctcct ggtccacccg gagaagcagg tccagccgga 1200
gctcctggtg aggctggtcc cccaggaccc gctggagctg aaggtgaggc aggtccagcc 1260
ggcgctccag gtgagccagg accagaaggt ccaccaggag aagctggagc acccggtcct 1320
ccaggagcac ccggcgctga aggagaaccc ggtgctcctg gagaacccgg tccagctggt 1380
gaagctggtg cacccggacc cgaaggtgcc gaaggagagg ctggtgaacc tggacccgcc 1440
ggtgaaccag gacctgaagg agctccaggt cctcctggac ccgcaggaga gcccggtcct 1500
gccggtgctc ctggtccacc cggagaagca ggtccagccg gagctcctgg tgaggctggt 1560
cccccaggac ccgctggagc tgaaggtgag gcaggtccag ccggcgctcc aggtgagcca 1620
ggaccagaag gtccaccagg agaagctgga gcacccggtc ctccaggagc acccggcgct 1680
gaaggagaac ccggtgctcc tggagaaccc ggtccagctg gtggatctgc taagtctaga 1740
actattggta ttattggtgc tccattttct aagggtcaac caagaggtgg tgttgaagaa 1800
ggtccaactg ttttgagaaa ggctggtttg ttggaaaagt tgaaggaaca agaatgtgat 1860
gttaaggatt acggtgattt gccatttgct gatattccaa acgattctcc atttcaaatt 1920
gttaagaacc caagatctgt tggtaaggct tctgaacaat tggctggtaa ggttgctgaa 1980
gttaagaaga acggtagaat ttctttggtt ttgggtggtg atcattcttt ggctattggt 2040
tctatttctg gtcatgctag agttcatcca gatttgggtg ttatttgggt tgatgctcat 2100
actgatatta acactccatt gactactact tctggtaact tgcatggtca accagtttct 2160
tttttgttga aggaattgaa gggtaagatt ccagatgttc caggtttttc ttgggttact 2220
ccatgtattt ctgctaagga tattgtttac attggtttga gagatgttga tccaggtgaa 2280
cattacattt tgaagacttt gggtattaag tacttttcta tgactgaagt tgatagattg 2340
ggtattggta aggttatgga agaaactttg tcttacttgt tgggtagaaa gaagagacca 2400
attcatttgt cttttgatgt tgatggtttg gatccatctt ttactccagc tactggtact 2460
ccagttgttg gtggtttgac ttacagagaa ggtttgtaca ttactgaaga aatttacaag 2520
actggtttgt tgtctggttt ggatattatg gaagttaacc catctttggg taagactcca 2580
gaagaagtta ctagaactgt taacactgct gttgctatta ctttggcttg ttttggtttg 2640
gctagagaag gtaaccataa gccaattgat tacttgaacc caccaaag 2688
<210> 241
<211> 782
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 241
Pro Glu Gly Gly Pro Gly Pro Pro Pro Ala Gly Ala Ala Ala Pro Pro
1 5 10 15
Pro Pro Gly Pro Gly Glu Gly Glu Glu Ala Gly Gly Pro Glu Pro Pro
20 25 30
Glu Pro Pro Ala Gly Gly Ala Gly Ala Gly Glu Gly Pro Pro Gly Pro
35 40 45
Pro Glu Ala Glu Pro Gly Glu Pro Gly Gly Pro Ala Pro Gly Pro Ala
50 55 60
Pro Gly Gly Gly Ala Gly Glu Pro Gly Gly Pro Ala Gly Pro Glu Gly
65 70 75 80
Glu Glu Ala Pro Gly Gly Glu Pro Ala Ala Ala Pro Pro Gly Pro Gly
85 90 95
Pro Pro Gly Ala Pro Ala Gly Pro Glu Gly Glu Gly Ala Pro Glu Gly
100 105 110
Glu Pro Pro Gly Pro Pro Ala Glu Pro Gly Gly Ala Ala Gly Ala Gly
115 120 125
Pro Gly Pro Pro Pro Gly Gly Gly Pro Ala Glu Ala Pro Pro Gly Gly
130 135 140
Pro Gly Pro Gly Gly Ala Pro Pro Ala Gly Gly Gly Glu Ala Glu Gly
145 150 155 160
Pro Pro Pro Glu Pro Glu Ala Glu Ala Ala Pro Gly Gly Ala Ala Gly
165 170 175
Glu Ala Pro Pro Gly Pro Gly Pro Ala Pro Pro Gly Ala Pro Ala Pro
180 185 190
Gly Pro Gly Gly Gly Pro Glu Pro Gly Ala Ala Pro Gly Gly Gly Ala
195 200 205
Ala Glu Glu Glu Pro Gly Ala Gly Pro Gly Pro Gly Glu Ala Gly Ala
210 215 220
Pro Ala Pro Glu Ala Ala Glu Pro Gly Pro Gly Pro Glu Glu Glu Gly
225 230 235 240
Glu Pro Gly Glu Ala Glu Gly Gly Pro Gly Pro Ala Gly Pro Ala Gly
245 250 255
Ala Gly Ala Pro Ala Ala Pro Gly Ala Pro Glu Ala Gly Gly Glu Glu
260 265 270
Pro Pro Pro Ala Pro Pro Gly Gly Pro Ala Ala Glu Gly Glu Ala Gly
275 280 285
Gly Pro Ala Glu Gly Gly Ala Pro Pro Ala Pro Pro Gly Ala Gly Gly
290 295 300
Ala Glu Glu Gly Pro Gly Ala Gly Glu Pro Ala Pro Gly Gly Glu Glu
305 310 315 320
Gly Pro Pro Ala Pro Ala Pro Ala Ala Pro Gly Pro Glu Ala Glu Glu
325 330 335
Gly Pro Ala Ala Pro Pro Pro Ala Pro Glu Pro Pro Gly Ala Ala Glu
340 345 350
Gly Gly Ala Ala Ala Pro Gly Gly Gly Gly Gly Ala Gly Gly Glu Gly
355 360 365
Gly Ala Glu Gly Ala Ala Gly Gly Gly Gly Glu Pro Ala Ala Gly Gly
370 375 380
Gly Gly Gly Pro Gly Glu Pro Gly Gly Gly Gly Pro Gly Gly Gly Ala
385 390 395 400
Gly Gly Gly Glu Glu Gly Glu Pro Pro Ala Pro Gly Pro Glu Pro Pro
405 410 415
Gly Pro Pro Ala Gly Ala Pro Pro Gly Ala Gly Glu Pro Gly Glu Glu
420 425 430
Gly Pro Ala Gly Gly Ala Pro Pro Gly Pro Glu Glu Glu Pro Gly Gly
435 440 445
Ala Gly Pro Glu Pro Ala Gly Gly Glu Gly Pro Gly Pro Ser Ala Lys
450 455 460
Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro
465 470 475 480
Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu
485 490 495
Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp
500 505 510
Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys
515 520 525
Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val
530 535 540
Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp
545 550 555 560
His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro
565 570 575
Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro
580 585 590
Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu
595 600 605
Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp
610 615 620
Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg
625 630 635 640
Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys
645 650 655
Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met
660 665 670
Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His
675 680 685
Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr
690 695 700
Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile
705 710 715 720
Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met
725 730 735
Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr
740 745 750
Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg
755 760 765
Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys
770 775 780
<210> 242
<211> 2346
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 242
ccagaaggtg gtccaggtcc accaccagct ggtgctgctg ctccaccacc accaggtcca 60
ggtgaaggtg aagaagctgg tggtccagaa ccaccagaac caccagctgg tggtgctggt 120
gctggtgaag gtccaccagg tccaccagaa gctgaaccag gtgaaccagg tggtccagct 180
ccaggtccag ctccaggtgg tggtgctggt gaaccaggtg gtccagctgg tccagaaggt 240
gaagaagctc caggtggtga accagctgct gctccaccag gtccaggtcc accaggtgct 300
ccagctggtc cagaaggtga aggtgctcca gaaggtgaac caccaggtcc accagctgaa 360
ccaggtggtg ctgctggtgc tggtccaggt ccaccaccag gtggtggtcc agctgaagct 420
ccaccaggtg gtccaggtcc aggtggtgct ccaccagctg gtggtggtga agctgaaggt 480
ccaccaccag aaccagaagc tgaagctgct ccaggtggtg ctgctggtga agctccacca 540
ggtccaggtc cagctccacc aggtgctcca gctccaggtc caggtggtgg tccagaacca 600
ggtgctgctc caggtggtgg tgctgctgaa gaagaaccag gtgctggtcc aggtccaggt 660
gaagctggtg ctccagctcc agaagctgct gaaccaggtc caggtccaga agaagaaggt 720
gaaccaggtg aagctgaagg tggtccaggt ccagctggtc cagctggtgc tggtgctcca 780
gctgctccag gtgctccaga agctggtggt gaagaaccac caccagctcc accaggtggt 840
ccagctgctg aaggtgaagc tggtggtcca gctgaaggtg gtgctccacc agctccacca 900
ggtgctggtg gtgctgaaga aggtccaggt gctggtgaac cagctccagg tggtgaagaa 960
ggtccaccag ctccagctcc agctgctcca ggtccagaag ctgaagaagg tccagctgct 1020
ccaccaccag ctccagaacc accaggtgct gctgaaggtg gtgctgctgc tccaggtggt 1080
ggtggtggtg ctggtggtga aggtggtgct gaaggtgctg ctggtggtgg tggtgaacca 1140
gctgctggtg gtggtggtgg tccaggtgaa ccaggtggtg gtggtccagg tggtggtgct 1200
ggtggtggtg aagaaggtga accaccagct ccaggtccag aaccaccagg tccaccagct 1260
ggtgctccac caggtgctgg tgaaccaggt gaagaaggtc cagctggtgg tgctccacca 1320
ggtccagaag aagaaccagg tggtgctggt ccagaaccag ctggtggtga aggtccaggt 1380
ccatctgcta agtctagaac tattggtatt attggtgctc cattttctaa gggtcaacca 1440
agaggtggtg ttgaagaagg tccaactgtt ttgagaaagg ctggtttgtt ggaaaagttg 1500
aaggaacaag aatgtgatgt taaggattac ggtgatttgc catttgctga tattccaaac 1560
gattctccat ttcaaattgt taagaaccca agatctgttg gtaaggcttc tgaacaattg 1620
gctggtaagg ttgctgaagt taagaagaac ggtagaattt ctttggtttt gggtggtgat 1680
cattctttgg ctattggttc tatttctggt catgctagag ttcatccaga tttgggtgtt 1740
atttgggttg atgctcatac tgatattaac actccattga ctactacttc tggtaacttg 1800
catggtcaac cagtttcttt tttgttgaag gaattgaagg gtaagattcc agatgttcca 1860
ggtttttctt gggttactcc atgtatttct gctaaggata ttgtttacat tggtttgaga 1920
gatgttgatc caggtgaaca ttacattttg aagactttgg gtattaagta cttttctatg 1980
actgaagttg atagattggg tattggtaag gttatggaag aaactttgtc ttacttgttg 2040
ggtagaaaga agagaccaat tcatttgtct tttgatgttg atggtttgga tccatctttt 2100
actccagcta ctggtactcc agttgttggt ggtttgactt acagagaagg tttgtacatt 2160
actgaagaaa tttacaagac tggtttgttg tctggtttgg atattatgga agttaaccca 2220
tctttgggta agactccaga agaagttact agaactgtta acactgctgt tgctattact 2280
ttggcttgtt ttggtttggc tagagaaggt aaccataagc caattgatta cttgaaccca 2340
ccaaag 2346
<210> 243
<211> 761
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 243
Gly Pro Pro Gly Glu Gln Gly Lys Pro Gly Asn Gln Gly Glu Pro Gly
1 5 10 15
Asn Pro Gly Ser Pro Gly Gln Pro Gly Asn Pro Gly Gln Pro Gly Ser
20 25 30
Pro Gly Asn Pro Gly Gln Pro Gly Asn Glu Gly Pro Gln Gly Ser Gln
35 40 45
Gly Asn Pro Gly Gln Pro Gly Glu Pro Gly Ser Asn Gly Gln Pro Gly
50 55 60
Gln Pro Gly Gln Asn Gly Lys Asn Gly Gln Pro Gly Ser Pro Gly Ser
65 70 75 80
Gln Gly Ser Pro Gly Asn Gln Gly Ser Pro Gly Asn Gln Gly Gln Pro
85 90 95
Gly Asn Lys Gly Glu Gln Gly Lys Pro Gly Asn Gln Gly Pro Ala Gly
100 105 110
Glu Gln Gly Lys Pro Gly Asn Gln Gly Glu Pro Gly Asn Pro Gly Ser
115 120 125
Pro Gly Gln Pro Gly Asn Pro Gly Gln Pro Gly Ser Pro Gly Asn Pro
130 135 140
Gly Gln Pro Gly Asn Glu Gly Pro Gln Gly Ser Gln Gly Asn Pro Gly
145 150 155 160
Gln Pro Gly Glu Pro Gly Ser Asn Gly Gln Pro Gly Gln Pro Gly Gln
165 170 175
Asn Gly Lys Asn Gly Gln Pro Gly Ser Pro Gly Ser Gln Gly Ser Pro
180 185 190
Gly Asn Gln Gly Ser Pro Gly Asn Gln Gly Gln Pro Gly Asn Lys Gly
195 200 205
Glu Gln Gly Lys Pro Gly Asn Gln Gly Pro Ala Gly Glu Gln Gly Lys
210 215 220
Pro Gly Asn Gln Gly Glu Pro Gly Asn Pro Gly Ser Pro Gly Gln Pro
225 230 235 240
Gly Asn Pro Gly Gln Pro Gly Ser Pro Gly Asn Pro Gly Gln Pro Gly
245 250 255
Asn Glu Gly Pro Gln Gly Ser Gln Gly Asn Pro Gly Gln Pro Gly Glu
260 265 270
Pro Gly Ser Asn Gly Gln Pro Gly Gln Pro Gly Gln Asn Gly Lys Asn
275 280 285
Gly Gln Pro Gly Ser Pro Gly Ser Gln Gly Ser Pro Gly Asn Gln Gly
290 295 300
Ser Pro Gly Asn Gln Gly Gln Pro Gly Asn Lys Gly Glu Gln Gly Lys
305 310 315 320
Pro Gly Asn Gln Gly Pro Ala Gly Glu Gln Gly Lys Pro Gly Asn Gln
325 330 335
Gly Glu Pro Gly Asn Pro Gly Ser Pro Gly Gln Pro Gly Asn Pro Gly
340 345 350
Gln Pro Gly Ser Pro Gly Asn Pro Gly Gln Pro Gly Asn Glu Gly Pro
355 360 365
Gln Gly Ser Gln Gly Asn Pro Gly Gln Pro Gly Glu Pro Gly Ser Asn
370 375 380
Gly Gln Pro Gly Gln Pro Gly Gln Asn Gly Lys Asn Gly Gln Pro Gly
385 390 395 400
Ser Pro Gly Ser Gln Gly Ser Pro Gly Asn Gln Gly Ser Pro Gly Asn
405 410 415
Gln Gly Gln Pro Gly Asn Lys Gly Glu Gln Gly Lys Pro Gly Asn Gln
420 425 430
Gly Pro Ala Gly Gly Ser Gly Gly Ser Ala Lys Ser Arg Thr Ile Gly
435 440 445
Ile Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro Arg Gly Gly Val Glu
450 455 460
Glu Gly Pro Thr Val Leu Arg Lys Ala Gly Leu Leu Glu Lys Leu Lys
465 470 475 480
Glu Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp Leu Pro Phe Ala Asp
485 490 495
Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys Asn Pro Arg Ser Val
500 505 510
Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val Ala Glu Val Lys Lys
515 520 525
Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp His Ser Leu Ala Ile
530 535 540
Gly Ser Ile Ser Gly His Ala Arg Val His Pro Asp Leu Gly Val Ile
545 550 555 560
Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro Leu Thr Thr Thr Ser
565 570 575
Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu Leu Lys Glu Leu Lys
580 585 590
Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp Val Thr Pro Cys Ile
595 600 605
Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg Asp Val Asp Pro Gly
610 615 620
Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys Tyr Phe Ser Met Thr
625 630 635 640
Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met Glu Glu Thr Leu Ser
645 650 655
Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His Leu Ser Phe Asp Val
660 665 670
Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr Gly Thr Pro Val Val
675 680 685
Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile Thr Glu Glu Ile Tyr
690 695 700
Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met Glu Val Asn Pro Ser
705 710 715 720
Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr Val Asn Thr Ala Val
725 730 735
Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg Glu Gly Asn His Lys
740 745 750
Pro Ile Asp Tyr Leu Asn Pro Pro Lys
755 760
<210> 244
<211> 2283
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 244
ggtccacccg gtgaacaagg taaaccagga aaccagggtg agccaggtaa cccaggttcc 60
cctggtcagc caggtaaccc tggtcaacca ggttctccag gtaatccagg tcaaccagga 120
aacgaaggtc cacaaggttc tcagggtaac cctggacaac ctggtgagcc aggttccaac 180
ggtcaacctg gtcaacctgg tcagaacgga aagaatggtc aacctggatc cccaggttca 240
caaggctctc caggtaacca aggatctcct ggtaaccaag gacagcccgg taacaagggt 300
gaacaaggta aaccaggaaa ccagggtcca gccggtgaac aaggtaaacc aggaaaccag 360
ggtgagccag gtaacccagg ttcccctggt cagccaggta accctggtca accaggttct 420
ccaggtaatc caggtcaacc aggaaacgaa ggtccacaag gttctcaggg taaccctgga 480
caacctggtg agccaggttc caacggtcaa cctggtcaac ctggtcagaa cggaaagaat 540
ggtcaacctg gatccccagg ttcacaaggc tctccaggta accaaggatc tcctggtaac 600
caaggacagc ccggtaacaa gggtgaacaa ggtaaaccag gaaaccaggg tccagccggt 660
gaacaaggta aaccaggaaa ccagggtgag ccaggtaacc caggttcccc tggtcagcca 720
ggtaaccctg gtcaaccagg ttctccaggt aatccaggtc aaccaggaaa cgaaggtcca 780
caaggttctc agggtaaccc tggacaacct ggtgagccag gttccaacgg tcaacctggt 840
caacctggtc agaacggaaa gaatggtcaa cctggatccc caggttcaca aggctctcca 900
ggtaaccaag gatctcctgg taaccaagga cagcccggta acaagggtga acaaggtaaa 960
ccaggaaacc agggtccagc cggtgaacaa ggtaaaccag gaaaccaggg tgagccaggt 1020
aacccaggtt cccctggtca gccaggtaac cctggtcaac caggttctcc aggtaatcca 1080
ggtcaaccag gaaacgaagg tccacaaggt tctcagggta accctggaca acctggtgag 1140
ccaggttcca acggtcaacc tggtcaacct ggtcagaacg gaaagaatgg tcaacctgga 1200
tccccaggtt cacaaggctc tccaggtaac caaggatctc ctggtaacca aggacagccc 1260
ggtaacaagg gtgaacaagg taaaccagga aaccagggtc cagccggtgg ctctggtgga 1320
tctgctaagt ctagaactat tggtattatt ggtgctccat tttctaaggg tcaaccaaga 1380
ggtggtgttg aagaaggtcc aactgttttg agaaaggctg gtttgttgga aaagttgaag 1440
gaacaagaat gtgatgttaa ggattacggt gatttgccat ttgctgatat tccaaacgat 1500
tctccatttc aaattgttaa gaacccaaga tctgttggta aggcttctga acaattggct 1560
ggtaaggttg ctgaagttaa gaagaacggt agaatttctt tggttttggg tggtgatcat 1620
tctttggcta ttggttctat ttctggtcat gctagagttc atccagattt gggtgttatt 1680
tgggttgatg ctcatactga tattaacact ccattgacta ctacttctgg taacttgcat 1740
ggtcaaccag tttctttttt gttgaaggaa ttgaagggta agattccaga tgttccaggt 1800
ttttcttggg ttactccatg tatttctgct aaggatattg tttacattgg tttgagagat 1860
gttgatccag gtgaacatta cattttgaag actttgggta ttaagtactt ttctatgact 1920
gaagttgata gattgggtat tggtaaggtt atggaagaaa ctttgtctta cttgttgggt 1980
agaaagaaga gaccaattca tttgtctttt gatgttgatg gtttggatcc atcttttact 2040
ccagctactg gtactccagt tgttggtggt ttgacttaca gagaaggttt gtacattact 2100
gaagaaattt acaagactgg tttgttgtct ggtttggata ttatggaagt taacccatct 2160
ttgggtaaga ctccagaaga agttactaga actgttaaca ctgctgttgc tattactttg 2220
gcttgttttg gtttggctag agaaggtaac cataagccaa ttgattactt gaacccacca 2280
aag 2283
<210> 245
<211> 472
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 245
Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly
1 5 10 15
Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu
20 25 30
Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu
35 40 45
Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly
50 55 60
Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu
65 70 75 80
Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu
85 90 95
Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly
100 105 110
Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu
115 120 125
Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu Gly Glu Glu
130 135 140
Gly Glu Glu Gly Glu Glu Gly Ser Ala Lys Ser Arg Thr Ile Gly Ile
145 150 155 160
Ile Gly Ala Pro Phe Ser Lys Gly Gln Pro Arg Gly Gly Val Glu Glu
165 170 175
Gly Pro Thr Val Leu Arg Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu
180 185 190
Gln Glu Cys Asp Val Lys Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile
195 200 205
Pro Asn Asp Ser Pro Phe Gln Ile Val Lys Asn Pro Arg Ser Val Gly
210 215 220
Lys Ala Ser Glu Gln Leu Ala Gly Lys Val Ala Glu Val Lys Lys Asn
225 230 235 240
Gly Arg Ile Ser Leu Val Leu Gly Gly Asp His Ser Leu Ala Ile Gly
245 250 255
Ser Ile Ser Gly His Ala Arg Val His Pro Asp Leu Gly Val Ile Trp
260 265 270
Val Asp Ala His Thr Asp Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly
275 280 285
Asn Leu His Gly Gln Pro Val Ser Phe Leu Leu Lys Glu Leu Lys Gly
290 295 300
Lys Ile Pro Asp Val Pro Gly Phe Ser Trp Val Thr Pro Cys Ile Ser
305 310 315 320
Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg Asp Val Asp Pro Gly Glu
325 330 335
His Tyr Ile Leu Lys Thr Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu
340 345 350
Val Asp Arg Leu Gly Ile Gly Lys Val Met Glu Glu Thr Leu Ser Tyr
355 360 365
Leu Leu Gly Arg Lys Lys Arg Pro Ile His Leu Ser Phe Asp Val Asp
370 375 380
Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr Gly Thr Pro Val Val Gly
385 390 395 400
Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile Thr Glu Glu Ile Tyr Lys
405 410 415
Thr Gly Leu Leu Ser Gly Leu Asp Ile Met Glu Val Asn Pro Ser Leu
420 425 430
Gly Lys Thr Pro Glu Glu Val Thr Arg Thr Val Asn Thr Ala Val Ala
435 440 445
Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg Glu Gly Asn His Lys Pro
450 455 460
Ile Asp Tyr Leu Asn Pro Pro Lys
465 470
<210> 246
<211> 1416
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 246
ggagaagaag gcgaagaagg cgaagaaggt gaggagggtg aggagggaga agaaggcgaa 60
gaaggcgaag aaggtgagga gggtgaggag ggagaagaag gcgaagaagg cgaagaaggt 120
gaggagggtg aggagggaga agaaggcgaa gaaggcgaag aaggtgagga gggtgaggag 180
ggagaagaag gcgaagaagg cgaagaaggt gaggagggtg aggagggaga agaaggcgaa 240
gaaggcgaag aaggtgagga gggtgaggag ggagaagaag gcgaagaagg cgaagaaggt 300
gaggagggtg aggagggaga agaaggcgaa gaaggcgaag aaggtgagga gggtgaggag 360
ggagaagaag gcgaagaagg cgaagaaggt gaggagggtg aggagggaga agaaggcgaa 420
gaaggcgaag aaggtgagga gggtgaggag ggaagcgcca agtccagaac catagggatt 480
attggagctc ctttctcaaa gggacagcca cgaggagggg tggaagaagg ccctacagta 540
ttgagaaagg ctggtctgct tgagaaactt aaagaacaag agtgtgatgt gaaggattat 600
ggggacctgc cctttgctga catccctaat gacagtccct ttcaaattgt gaagaatcca 660
aggtctgtgg gaaaagcaag cgagcagctg gctggcaagg tggcagaagt caagaagaac 720
ggaagaatca gcctggtgct gggcggagac cacagtttgg caattggaag catctctggc 780
catgccaggg tccaccctga tcttggagtc atctgggtgg atgctcacac tgatatcaac 840
actccactga caaccacaag tggaaacttg catggacaac ctgtatcttt cctcctgaag 900
gaactaaaag gaaagattcc cgatgtgcca ggattctcct gggtgactcc ctgtatatct 960
gccaaggata ttgtgtatat tggcttgaga gacgtggacc ctggggaaca ctacattttg 1020
aaaactctag gcattaaata cttttcaatg actgaagtgg acagactagg aattggcaag 1080
gtgatggaag aaacactcag ctatctacta ggaagaaaga aaaggccaat tcatctaagt 1140
tttgatgttg acggactgga cccatctttc acaccagcta ctggcacacc agtcgtggga 1200
ggtctgacat acagagaagg tctctacatc acagaagaaa tctacaaaac agggctactc 1260
tcaggattag atataatgga agtgaaccca tccctgggga agacaccaga agaagtaact 1320
cgaacagtga acacagcagt tgcaataacc ttggcttgtt tcggacttgc tcgggagggt 1380
aatcacaagc ctattgacta ccttaaccca cctaag 1416
<210> 247
<211> 293
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 247
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Gly Thr Pro Leu Gly Pro Ala Ser Ser Leu
115 120 125
Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln
130 135 140
Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu
145 150 155 160
Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro
165 170 175
Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly
180 185 190
Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu
195 200 205
Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr
210 215 220
Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met
225 230 235 240
Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met
245 250 255
Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val
260 265 270
Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg
275 280 285
His Leu Ala Gln Pro
290
<210> 248
<211> 879
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 248
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc tggtggaact 360
ccattgggtc cagcttcttc tttgccacaa tcttttttgt tgaagtgttt ggaacaagtt 420
agaaagattc aaggtgatgg tgctgctttg caagaaaagt tgtgtgctac ttacaagttg 480
tgtcatccag aagaattggt tttgttgggt cattctttgg gtattccatg ggctccattg 540
tcttcttgtc catctcaagc tttgcaattg gctggttgtt tgtctcaatt gcattctggt 600
ttgtttttgt accaaggttt gttgcaagct ttggaaggta tttctccaga attgggtcca 660
actttggata ctttgcaatt ggatgttgct gattttgcta ctactatttg gcaacaaatg 720
gaagaattgg gtatggctcc agctttgcaa ccaactcaag gtgctatgcc agcttttgct 780
tctgcttttc aaagaagagc tggtggtgtt ttggttgctt ctcatttgca atcttttttg 840
gaagtttctt acagagtttt gagacatttg gctcaacca 879
<210> 249
<211> 283
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 249
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala
20 25 30
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
35 40 45
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Thr Pro Leu
100 105 110
Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu
115 120 125
Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu
130 135 140
Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly
145 150 155 160
His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln
165 170 175
Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe
180 185 190
Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu
195 200 205
Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr
210 215 220
Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln
225 230 235 240
Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg
245 250 255
Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val
260 265 270
Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro
275 280
<210> 250
<211> 849
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 250
ggtccaccag gtgaagctgg tgctccaggt ccagaaggtg ctgaaggtga agctggtgaa 60
ccaggtccag ctggtgaacc aggtccagct ggtgctccag gtgaagctgg tccaccaggt 120
ccagctggtg ctgaaggtga agctggtcca gctggtgctc caggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 300
gctccaggtc caccaggtga agctggtact ccattgggtc cagcttcttc tttgccacaa 360
tcttttttgt tgaagtgttt ggaacaagtt agaaagattc aaggtgatgg tgctgctttg 420
caagaaaagt tgtgtgctac ttacaagttg tgtcatccag aagaattggt tttgttgggt 480
cattctttgg gtattccatg ggctccattg tcttcttgtc catctcaagc tttgcaattg 540
gctggttgtt tgtctcaatt gcattctggt ttgtttttgt accaaggttt gttgcaagct 600
ttggaaggta tttctccaga attgggtcca actttggata ctttgcaatt ggatgttgct 660
gattttgcta ctactatttg gcaacaaatg gaagaattgg gtatggctcc agctttgcaa 720
ccaactcaag gtgctatgcc agcttttgct tctgcttttc aaagaagagc tggtggtgtt 780
ttggttgctt ctcatttgca atcttttttg gaagtttctt acagagtttt gagacatttg 840
gctcaacca 849
<210> 251
<211> 283
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 251
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
1 5 10 15
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu
20 25 30
Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro
35 40 45
Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Thr Pro Leu
100 105 110
Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu
115 120 125
Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu
130 135 140
Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly
145 150 155 160
His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln
165 170 175
Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe
180 185 190
Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu
195 200 205
Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr
210 215 220
Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln
225 230 235 240
Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg
245 250 255
Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val
260 265 270
Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro
275 280
<210> 252
<211> 849
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 252
ggtccagctg gtgctccagg tgaagctggt ccaccaggtc cagctggtgc tgaaggtgaa 60
gctggtccag ctggtgctcc aggtccacca ggtgaagctg gtgctccagg tccagaaggt 120
gctgaaggtg aagctggtga accaggtcca gctggtgaac caggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 300
gctccaggtc caccaggtga agctggtact ccattgggtc cagcttcttc tttgccacaa 360
tcttttttgt tgaagtgttt ggaacaagtt agaaagattc aaggtgatgg tgctgctttg 420
caagaaaagt tgtgtgctac ttacaagttg tgtcatccag aagaattggt tttgttgggt 480
cattctttgg gtattccatg ggctccattg tcttcttgtc catctcaagc tttgcaattg 540
gctggttgtt tgtctcaatt gcattctggt ttgtttttgt accaaggttt gttgcaagct 600
ttggaaggta tttctccaga attgggtcca actttggata ctttgcaatt ggatgttgct 660
gattttgcta ctactatttg gcaacaaatg gaagaattgg gtatggctcc agctttgcaa 720
ccaactcaag gtgctatgcc agcttttgct tctgcttttc aaagaagagc tggtggtgtt 780
ttggttgctt ctcatttgca atcttttttg gaagtttctt acagagtttt gagacatttg 840
gctcaacca 849
<210> 253
<211> 283
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 253
Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly
1 5 10 15
Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Pro
20 25 30
Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
35 40 45
Gly Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly
50 55 60
Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu
65 70 75 80
Ala Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu
85 90 95
Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Thr Pro Leu
100 105 110
Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu
115 120 125
Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu
130 135 140
Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly
145 150 155 160
His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln
165 170 175
Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe
180 185 190
Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu
195 200 205
Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr
210 215 220
Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln
225 230 235 240
Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg
245 250 255
Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val
260 265 270
Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro
275 280
<210> 254
<211> 849
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 254
ggtccagaag gtgctccagg tccaccaggt ccagctggtg aaccaggtcc agctggtgct 60
ccaggtccac caggtgaagc tggtgaacca ggtccagaag gtccaccagg tgaagctggt 120
gctccaggtc caccaggtgc tccaggtgct gaaggtgaac caggtccaga aggtgctcca 180
ggtccaccag gtccagctgg tgaaccaggt ccagctggtg ctccaggtcc accaggtgaa 240
gctggtccac caggtgaagc tggtgctcca ggtccagaag gtgctgaagg tgaagctggt 300
gaaccaggtc cagctggtga accaggtact ccattgggtc cagcttcttc tttgccacaa 360
tcttttttgt tgaagtgttt ggaacaagtt agaaagattc aaggtgatgg tgctgctttg 420
caagaaaagt tgtgtgctac ttacaagttg tgtcatccag aagaattggt tttgttgggt 480
cattctttgg gtattccatg ggctccattg tcttcttgtc catctcaagc tttgcaattg 540
gctggttgtt tgtctcaatt gcattctggt ttgtttttgt accaaggttt gttgcaagct 600
ttggaaggta tttctccaga attgggtcca actttggata ctttgcaatt ggatgttgct 660
gattttgcta ctactatttg gcaacaaatg gaagaattgg gtatggctcc agctttgcaa 720
ccaactcaag gtgctatgcc agcttttgct tctgcttttc aaagaagagc tggtggtgtt 780
ttggttgctt ctcatttgca atcttttttg gaagtttctt acagagtttt gagacatttg 840
gctcaacca 849
<210> 255
<211> 283
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 255
Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly
1 5 10 15
Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu
20 25 30
Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala
35 40 45
Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly
50 55 60
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro
65 70 75 80
Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu
85 90 95
Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Thr Pro Leu
100 105 110
Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu
115 120 125
Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu
130 135 140
Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly
145 150 155 160
His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln
165 170 175
Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe
180 185 190
Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu
195 200 205
Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr
210 215 220
Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln
225 230 235 240
Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg
245 250 255
Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val
260 265 270
Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro
275 280
<210> 256
<211> 849
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 256
ggtccagaag gtgctgaagg tgaagctggt gaaccaggtc cagctggtga accaggtcca 60
gaaggtgctc caggtccacc aggtccagct ggtgaaccag gtccagctgg tgctccaggt 120
ccaccaggtg aagctggtcc agctggtgct ccaggtgaag ctggtccacc aggtccagct 180
ggtgctgaag gtgaagctgg tccagctggt gctccaggtg aaccaggtcc agaaggtcca 240
ccaggtgaag ctggtgctcc aggtccacca ggtgctccag gtgctgaagg tgaaccaggt 300
gctccaggtg aaccaggtcc agctggtact ccattgggtc cagcttcttc tttgccacaa 360
tcttttttgt tgaagtgttt ggaacaagtt agaaagattc aaggtgatgg tgctgctttg 420
caagaaaagt tgtgtgctac ttacaagttg tgtcatccag aagaattggt tttgttgggt 480
cattctttgg gtattccatg ggctccattg tcttcttgtc catctcaagc tttgcaattg 540
gctggttgtt tgtctcaatt gcattctggt ttgtttttgt accaaggttt gttgcaagct 600
ttggaaggta tttctccaga attgggtcca actttggata ctttgcaatt ggatgttgct 660
gattttgcta ctactatttg gcaacaaatg gaagaattgg gtatggctcc agctttgcaa 720
ccaactcaag gtgctatgcc agcttttgct tctgcttttc aaagaagagc tggtggtgtt 780
ttggttgctt ctcatttgca atcttttttg gaagtttctt acagagtttt gagacatttg 840
gctcaacca 849
<210> 257
<211> 283
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 257
Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly
1 5 10 15
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro
20 25 30
Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro
35 40 45
Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly
50 55 60
Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro
65 70 75 80
Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu
85 90 95
Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Thr Pro Leu
100 105 110
Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu
115 120 125
Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu
130 135 140
Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly
145 150 155 160
His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln
165 170 175
Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe
180 185 190
Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu
195 200 205
Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr
210 215 220
Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln
225 230 235 240
Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg
245 250 255
Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val
260 265 270
Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro
275 280
<210> 258
<211> 849
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 258
ggtccagctg gtgaaccagg tccagctggt gctccaggtc caccaggtga agctggtcca 60
gctggtgctc caggtgaagc tggtccacca ggtccagctg gtgctgaagg tgaagctggt 120
ccagctggtg ctccaggtga accaggtcca gaaggtccac caggtccaga aggtgctgaa 180
ggtgaagctg gtgaaccagg tccagctggt gaaccaggtc cagaaggtgc tccaggtcca 240
ccaggtgaag ctggtgctcc aggtccacca ggtgctccag gtgctgaagg tgaaccaggt 300
gctccaggtg aaccaggtcc agctggtact ccattgggtc cagcttcttc tttgccacaa 360
tcttttttgt tgaagtgttt ggaacaagtt agaaagattc aaggtgatgg tgctgctttg 420
caagaaaagt tgtgtgctac ttacaagttg tgtcatccag aagaattggt tttgttgggt 480
cattctttgg gtattccatg ggctccattg tcttcttgtc catctcaagc tttgcaattg 540
gctggttgtt tgtctcaatt gcattctggt ttgtttttgt accaaggttt gttgcaagct 600
ttggaaggta tttctccaga attgggtcca actttggata ctttgcaatt ggatgttgct 660
gattttgcta ctactatttg gcaacaaatg gaagaattgg gtatggctcc agctttgcaa 720
ccaactcaag gtgctatgcc agcttttgct tctgcttttc aaagaagagc tggtggtgtt 780
ttggttgctt ctcatttgca atcttttttg gaagtttctt acagagtttt gagacatttg 840
gctcaacca 849
<210> 259
<211> 283
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 259
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
1 5 10 15
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala
20 25 30
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
35 40 45
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly
50 55 60
Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro
65 70 75 80
Ala Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro
85 90 95
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Thr Pro Leu
100 105 110
Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu
115 120 125
Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu
130 135 140
Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly
145 150 155 160
His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln
165 170 175
Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe
180 185 190
Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu
195 200 205
Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr
210 215 220
Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln
225 230 235 240
Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg
245 250 255
Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val
260 265 270
Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro
275 280
<210> 260
<211> 849
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 260
ggtccaccag gtccagctgg tgctgaaggt gaagctggtc cagctggtgc tccaggtgaa 60
ccaggtccag aaggtccacc aggtccagaa ggtgctgaag gtgaagctgg tgaaccaggt 120
ccagctggtg aaccaggtcc agaaggtgct ccaggtccac caggtgaagc tggtgctcca 180
ggtccaccag gtgctccagg tgctgaaggt gaaccaggtg ctccaggtga accaggtcca 240
gctggtccag ctggtgaacc aggtccagct ggtgctccag gtccaccagg tgaagctggt 300
ccagctggtg ctccaggtga agctggtact ccattgggtc cagcttcttc tttgccacaa 360
tcttttttgt tgaagtgttt ggaacaagtt agaaagattc aaggtgatgg tgctgctttg 420
caagaaaagt tgtgtgctac ttacaagttg tgtcatccag aagaattggt tttgttgggt 480
cattctttgg gtattccatg ggctccattg tcttcttgtc catctcaagc tttgcaattg 540
gctggttgtt tgtctcaatt gcattctggt ttgtttttgt accaaggttt gttgcaagct 600
ttggaaggta tttctccaga attgggtcca actttggata ctttgcaatt ggatgttgct 660
gattttgcta ctactatttg gcaacaaatg gaagaattgg gtatggctcc agctttgcaa 720
ccaactcaag gtgctatgcc agcttttgct tctgcttttc aaagaagagc tggtggtgtt 780
ttggttgctt ctcatttgca atcttttttg gaagtttctt acagagtttt gagacatttg 840
gctcaacca 849
<210> 261
<211> 614
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 261
Gly Pro Pro Gly Glu Gln Gly Lys Pro Gly Asn Gln Gly Glu Pro Gly
1 5 10 15
Asn Pro Gly Ser Pro Gly Gln Pro Gly Asn Pro Gly Gln Pro Gly Ser
20 25 30
Pro Gly Asn Pro Gly Gln Pro Gly Asn Glu Gly Pro Gln Gly Ser Gln
35 40 45
Gly Asn Pro Gly Gln Pro Gly Glu Pro Gly Ser Asn Gly Gln Pro Gly
50 55 60
Gln Pro Gly Gln Asn Gly Lys Asn Gly Gln Pro Gly Ser Pro Gly Ser
65 70 75 80
Gln Gly Ser Pro Gly Asn Gln Gly Ser Pro Gly Asn Gln Gly Gln Pro
85 90 95
Gly Asn Lys Gly Glu Gln Gly Lys Pro Gly Asn Gln Gly Pro Ala Gly
100 105 110
Glu Gln Gly Lys Pro Gly Asn Gln Gly Glu Pro Gly Asn Pro Gly Ser
115 120 125
Pro Gly Gln Pro Gly Asn Pro Gly Gln Pro Gly Ser Pro Gly Asn Pro
130 135 140
Gly Gln Pro Gly Asn Glu Gly Pro Gln Gly Ser Gln Gly Asn Pro Gly
145 150 155 160
Gln Pro Gly Glu Pro Gly Ser Asn Gly Gln Pro Gly Gln Pro Gly Gln
165 170 175
Asn Gly Lys Asn Gly Gln Pro Gly Ser Pro Gly Ser Gln Gly Ser Pro
180 185 190
Gly Asn Gln Gly Ser Pro Gly Asn Gln Gly Gln Pro Gly Asn Lys Gly
195 200 205
Glu Gln Gly Lys Pro Gly Asn Gln Gly Pro Ala Gly Glu Gln Gly Lys
210 215 220
Pro Gly Asn Gln Gly Glu Pro Gly Asn Pro Gly Ser Pro Gly Gln Pro
225 230 235 240
Gly Asn Pro Gly Gln Pro Gly Ser Pro Gly Asn Pro Gly Gln Pro Gly
245 250 255
Asn Glu Gly Pro Gln Gly Ser Gln Gly Asn Pro Gly Gln Pro Gly Glu
260 265 270
Pro Gly Ser Asn Gly Gln Pro Gly Gln Pro Gly Gln Asn Gly Lys Asn
275 280 285
Gly Gln Pro Gly Ser Pro Gly Ser Gln Gly Ser Pro Gly Asn Gln Gly
290 295 300
Ser Pro Gly Asn Gln Gly Gln Pro Gly Asn Lys Gly Glu Gln Gly Lys
305 310 315 320
Pro Gly Asn Gln Gly Pro Ala Gly Glu Gln Gly Lys Pro Gly Asn Gln
325 330 335
Gly Glu Pro Gly Asn Pro Gly Ser Pro Gly Gln Pro Gly Asn Pro Gly
340 345 350
Gln Pro Gly Ser Pro Gly Asn Pro Gly Gln Pro Gly Asn Glu Gly Pro
355 360 365
Gln Gly Ser Gln Gly Asn Pro Gly Gln Pro Gly Glu Pro Gly Ser Asn
370 375 380
Gly Gln Pro Gly Gln Pro Gly Gln Asn Gly Lys Asn Gly Gln Pro Gly
385 390 395 400
Ser Pro Gly Ser Gln Gly Ser Pro Gly Asn Gln Gly Ser Pro Gly Asn
405 410 415
Gln Gly Gln Pro Gly Asn Lys Gly Glu Gln Gly Lys Pro Gly Asn Gln
420 425 430
Gly Pro Ala Gly Gly Ser Gly Gly Thr Pro Leu Gly Pro Ala Ser Ser
435 440 445
Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile
450 455 460
Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys
465 470 475 480
Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile
485 490 495
Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala
500 505 510
Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu
515 520 525
Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp
530 535 540
Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln
545 550 555 560
Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala
565 570 575
Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu
580 585 590
Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu
595 600 605
Arg His Leu Ala Gln Pro
610
<210> 262
<211> 1842
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 262
ggtccacccg gtgaacaagg taaaccagga aaccagggtg agccaggtaa cccaggttcc 60
cctggtcagc caggtaaccc tggtcaacca ggttctccag gtaatccagg tcaaccagga 120
aacgaaggtc cacaaggttc tcagggtaac cctggacaac ctggtgagcc aggttccaac 180
ggtcaacctg gtcaacctgg tcagaacgga aagaatggtc aacctggatc cccaggttca 240
caaggctctc caggtaacca aggatctcct ggtaaccaag gacagcccgg taacaagggt 300
gaacaaggta aaccaggaaa ccagggtcca gccggtgaac aaggtaaacc aggaaaccag 360
ggtgagccag gtaacccagg ttcccctggt cagccaggta accctggtca accaggttct 420
ccaggtaatc caggtcaacc aggaaacgaa ggtccacaag gttctcaggg taaccctgga 480
caacctggtg agccaggttc caacggtcaa cctggtcaac ctggtcagaa cggaaagaat 540
ggtcaacctg gatccccagg ttcacaaggc tctccaggta accaaggatc tcctggtaac 600
caaggacagc ccggtaacaa gggtgaacaa ggtaaaccag gaaaccaggg tccagccggt 660
gaacaaggta aaccaggaaa ccagggtgag ccaggtaacc caggttcccc tggtcagcca 720
ggtaaccctg gtcaaccagg ttctccaggt aatccaggtc aaccaggaaa cgaaggtcca 780
caaggttctc agggtaaccc tggacaacct ggtgagccag gttccaacgg tcaacctggt 840
caacctggtc agaacggaaa gaatggtcaa cctggatccc caggttcaca aggctctcca 900
ggtaaccaag gatctcctgg taaccaagga cagcccggta acaagggtga acaaggtaaa 960
ccaggaaacc agggtccagc cggtgaacaa ggtaaaccag gaaaccaggg tgagccaggt 1020
aacccaggtt cccctggtca gccaggtaac cctggtcaac caggttctcc aggtaatcca 1080
ggtcaaccag gaaacgaagg tccacaaggt tctcagggta accctggaca acctggtgag 1140
ccaggttcca acggtcaacc tggtcaacct ggtcagaacg gaaagaatgg tcaacctgga 1200
tccccaggtt cacaaggctc tccaggtaac caaggatctc ctggtaacca aggacagccc 1260
ggtaacaagg gtgaacaagg taaaccagga aaccagggtc cagccggtgg ctctggtgga 1320
actccattgg gtccagcttc ttctttgcca caatcttttt tgttgaagtg tttggaacaa 1380
gttagaaaga ttcaaggtga tggtgctgct ttgcaagaaa agttgtgtgc tacttacaag 1440
ttgtgtcatc cagaagaatt ggttttgttg ggtcattctt tgggtattcc atgggctcca 1500
ttgtcttctt gtccatctca agctttgcaa ttggctggtt gtttgtctca attgcattct 1560
ggtttgtttt tgtaccaagg tttgttgcaa gctttggaag gtatttctcc agaattgggt 1620
ccaactttgg atactttgca attggatgtt gctgattttg ctactactat ttggcaacaa 1680
atggaagaat tgggtatggc tccagctttg caaccaactc aaggtgctat gccagctttt 1740
gcttctgctt ttcaaagaag agctggtggt gttttggttg cttctcattt gcaatctttt 1800
ttggaagttt cttacagagt tttgagacat ttggctcaac ca 1842
<210> 263
<211> 1225
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 263
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
130 135 140
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
165 170 175
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
180 185 190
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
210 215 220
Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu
225 230 235 240
Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly
245 250 255
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
260 265 270
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro
275 280 285
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
290 295 300
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu
305 310 315 320
Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro
325 330 335
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly
340 345 350
Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu
355 360 365
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
370 375 380
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly
385 390 395 400
Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu
405 410 415
Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro
420 425 430
Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly
435 440 445
Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala
450 455 460
Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala
465 470 475 480
Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly
485 490 495
Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro
500 505 510
Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu
515 520 525
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly
530 535 540
Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala
545 550 555 560
Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala
565 570 575
Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly
580 585 590
Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
595 600 605
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
610 615 620
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
625 630 635 640
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
645 650 655
Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
660 665 670
Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly
675 680 685
Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu
690 695 700
Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro
705 710 715 720
Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly
725 730 735
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro
740 745 750
Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro
755 760 765
Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly
770 775 780
Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro
785 790 795 800
Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala
805 810 815
Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly
820 825 830
Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro
835 840 845
Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro
850 855 860
Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly
865 870 875 880
Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro
885 890 895
Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro
900 905 910
Gly Pro Ala Gly Gly Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp
915 920 925
Asn Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr
930 935 940
Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser
945 950 955 960
Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro
965 970 975
Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu
980 985 990
Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln
995 1000 1005
Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp
1010 1015 1020
Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr
1025 1030 1035 1040
Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe
1045 1050 1055
Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala
1060 1065 1070
Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp
1075 1080 1085
Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly
1090 1095 1100
Ser Cys Gly Phe Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu
1105 1110 1115 1120
Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly
1125 1130 1135
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
1140 1145 1150
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro
1155 1160 1165
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
1170 1175 1180
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu
1185 1190 1195 1200
Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro
1205 1210 1215
Gly Ala Pro Gly Glu Pro Gly Pro Ala
1220 1225
<210> 264
<211> 3675
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 264
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc tggtgaagct 360
ggtgcacccg gacccgaagg tgccgaagga gaggctggtg aacctggacc cgccggtgaa 420
ccaggacctg aaggagctcc aggtcctcct ggacccgcag gagagcccgg tcctgccggt 480
gctcctggtc cacccggaga agcaggtcca gccggagctc ctggtgaggc tggtccccca 540
ggacccgctg gagctgaagg tgaggcaggt ccagccggcg ctccaggtga gccaggacca 600
gaaggtccac caggagaagc tggagcaccc ggtcctccag gagcacccgg cgctgaagga 660
gaacccggtg ctcctggaga acccggtcca gctggtgaag ctggtgcacc cggacccgaa 720
ggtgccgaag gagaggctgg tgaacctgga cccgccggtg aaccaggacc tgaaggagct 780
ccaggtcctc ctggacccgc aggagagccc ggtcctgccg gtgctcctgg tccacccgga 840
gaagcaggtc cagccggagc tcctggtgag gctggtcccc caggacccgc tggagctgaa 900
ggtgaggcag gtccagccgg cgctccaggt gagccaggac cagaaggtcc accaggagaa 960
gctggagcac ccggtcctcc aggagcaccc ggcgctgaag gagaacccgg tgctcctgga 1020
gaacccggtc cagctggtga agctggtgca cccggacccg aaggtgccga aggagaggct 1080
ggtgaacctg gacccgccgg tgaaccagga cctgaaggag ctccaggtcc tcctggaccc 1140
gcaggagagc ccggtcctgc cggtgctcct ggtccacccg gagaagcagg tccagccgga 1200
gctcctggtg aggctggtcc cccaggaccc gctggagctg aaggtgaggc aggtccagcc 1260
ggcgctccag gtgagccagg accagaaggt ccaccaggag aagctggagc acccggtcct 1320
ccaggagcac ccggcgctga aggagaaccc ggtgctcctg gagaacccgg tccagctggt 1380
gaagctggtg cacccggacc cgaaggtgcc gaaggagagg ctggtgaacc tggacccgcc 1440
ggtgaaccag gacctgaagg agctccaggt cctcctggac ccgcaggaga gcccggtcct 1500
gccggtgctc ctggtccacc cggagaagca ggtccagccg gagctcctgg tgaggctggt 1560
cccccaggac ccgctggagc tgaaggtgag gcaggtccag ccggcgctcc aggtgagcca 1620
ggaccagaag gtccaccagg agaagctgga gcacccggtc ctccaggagc acccggcgct 1680
gaaggagaac ccggtgctcc tggagaaccc ggtccagctg gtgaagctgg tgcacccgga 1740
cccgaaggtg ccgaaggaga ggctggtgaa cctggacccg ccggtgaacc aggacctgaa 1800
ggagctccag gtcctcctgg acccgcagga gagcccggtc ctgccggtgc tcctggtcca 1860
cccggagaag caggtccagc cggagctcct ggtgaggctg gtcccccagg acccgctgga 1920
gctgaaggtg aggcaggtcc agccggcgct ccaggtgagc caggaccaga aggtccacca 1980
ggagaagctg gagcacccgg tcctccagga gcacccggcg ctgaaggaga acccggtgct 2040
cctggagaac ccggtccagc tggtgaagct ggtgcacccg gacccgaagg tgccgaagga 2100
gaggctggtg aacctggacc cgccggtgaa ccaggacctg aaggagctcc aggtcctcct 2160
ggacccgcag gagagcccgg tcctgccggt gctcctggtc cacccggaga agcaggtcca 2220
gccggagctc ctggtgaggc tggtccccca ggacccgctg gagctgaagg tgaggcaggt 2280
ccagccggcg ctccaggtga gccaggacca gaaggtccac caggagaagc tggagcaccc 2340
ggtcctccag gagcacccgg cgctgaagga gaacccggtg ctcctggaga acccggtcca 2400
gctggtgaag ctggtgcacc cggacccgaa ggtgccgaag gagaggctgg tgaacctgga 2460
cccgccggtg aaccaggacc tgaaggagct ccaggtcctc ctggacccgc aggagagccc 2520
ggtcctgccg gtgctcctgg tccacccgga gaagcaggtc cagccggagc tcctggtgag 2580
gctggtcccc caggacccgc tggagctgaa ggtgaggcag gtccagccgg cgctccaggt 2640
gagccaggac cagaaggtcc accaggagaa gctggagcac ccggtcctcc aggagcaccc 2700
ggcgctgaag gagaacccgg tgctcctgga gaacccggtc cagctggtgg attcccaact 2760
attccattgt ctagattgtt cgacaacgct atgttgagag cccacagatt gcaccaattg 2820
gctttcgaca cttaccaaga attcgaagaa gcttacattc caaaggaaca gaagtactct 2880
ttcttgcaaa acccacaaac ttctttgtgt ttctctgaat ctattccaac tccatctaac 2940
agagaagaaa ctcaacaaaa gtctaacttg gaattgttga gaatttcttt gttgttgatt 3000
caatcttggt tggaaccagt tcaattcttg agatctgttt tcgctaactc tttggtttac 3060
ggtgcttctg actctaacgt ttacgacttg ttgaaggact tggaagaagg tattcaaact 3120
ttgatgggta gattggaaga cggttctcct agaactggtc aaattttcaa gcaaacttac 3180
tctaagttcg acactaactc tcacaacgac gacgctttgt tgaagaacta cggtttgttg 3240
tactgtttca gaaaggacat ggacaaggtt gaaactttct tgagaattgt tcaatgtaga 3300
tctgttgaag gttcttgtgg tttcggtcca cctggtgaag ctggtgcacc cggacccgaa 3360
ggtgccgaag gagaggctgg tgaacctgga cccgccggtg aaccaggacc tgaaggagct 3420
ccaggtcctc ctggacccgc aggagagccc ggtcctgccg gtgctcctgg tccacccgga 3480
gaagcaggtc cagccggagc tcctggtgag gctggtcccc caggacccgc tggagctgaa 3540
ggtgaggcag gtccagccgg cgctccaggt gagccaggac cagaaggtcc accaggagaa 3600
gctggagcac ccggtcctcc aggagcaccc ggcgctgaag gagaacccgg tgctcctgga 3660
gaacccggtc cagct 3675
<210> 265
<211> 1164
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 265
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala
20 25 30
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
35 40 45
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Pro Gly
100 105 110
Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu
115 120 125
Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Glu Ala
130 135 140
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala
165 170 175
Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu
180 185 190
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Ala
210 215 220
Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala
225 230 235 240
Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly
245 250 255
Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
260 265 270
Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro
275 280 285
Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly
290 295 300
Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro
305 310 315 320
Pro Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu
325 330 335
Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly
340 345 350
Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala
355 360 365
Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu
370 375 380
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly
385 390 395 400
Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
405 410 415
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
420 425 430
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
435 440 445
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala
450 455 460
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
465 470 475 480
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
485 490 495
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
500 505 510
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
515 520 525
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Pro Gly
530 535 540
Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu
545 550 555 560
Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Glu Ala
565 570 575
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
580 585 590
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala
595 600 605
Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu
610 615 620
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
625 630 635 640
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Ala
645 650 655
Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala
660 665 670
Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly
675 680 685
Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
690 695 700
Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro
705 710 715 720
Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly
725 730 735
Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro
740 745 750
Pro Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu
755 760 765
Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly
770 775 780
Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala
785 790 795 800
Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu
805 810 815
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly
820 825 830
Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
835 840 845
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
850 855 860
Gly Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu
865 870 875 880
Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe
885 890 895
Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn
900 905 910
Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn
915 920 925
Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser
930 935 940
Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser
945 950 955 960
Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr
965 970 975
Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg
980 985 990
Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr
995 1000 1005
Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn
1010 1015 1020
Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr
1025 1030 1035 1040
Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe
1045 1050 1055
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1060 1065 1070
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala
1075 1080 1085
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
1090 1095 1100
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
1105 1110 1115 1120
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
1125 1130 1135
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
1140 1145 1150
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
1155 1160
<210> 266
<211> 3492
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 266
ggtccaccag gtgaagctgg tgctccaggt ccagaaggtg ctgaaggtga agctggtgaa 60
ccaggtccag ctggtgaacc aggtccagct ggtgctccag gtgaagctgg tccaccaggt 120
ccagctggtg ctgaaggtga agctggtcca gctggtgctc caggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 300
gctccaggtc caccaggtga agctggtcca ccaggtgaag ctggtgctcc aggtccagaa 360
ggtgctgaag gtgaagctgg tgaaccaggt ccagctggtg aaccaggtcc agctggtgct 420
ccaggtgaag ctggtccacc aggtccagct ggtgctgaag gtgaagctgg tccagctggt 480
gctccaggtg aaccaggtcc agaaggtcca ccaggtgaag ctggtgctcc aggtccacca 540
ggtgctccag gtgctgaagg tgaaccaggt ccagaaggtg ctccaggtcc accaggtcca 600
gctggtgaac caggtccagc tggtgctcca ggtccaccag gtgaagctgg tccaccaggt 660
gaagctggtg ctccaggtcc agaaggtgct gaaggtgaag ctggtgaacc aggtccagct 720
ggtgaaccag gtccagctgg tgctccaggt gaagctggtc caccaggtcc agctggtgct 780
gaaggtgaag ctggtccagc tggtgctcca ggtgaaccag gtccagaagg tccaccaggt 840
gaagctggtg ctccaggtcc accaggtgct ccaggtgctg aaggtgaacc aggtccagaa 900
ggtgctccag gtccaccagg tccagctggt gaaccaggtc cagctggtgc tccaggtcca 960
ccaggtgaag ctggtccacc aggtgaagct ggtgctccag gtccagaagg tgctgaaggt 1020
gaagctggtg aaccaggtcc agctggtgaa ccaggtccag ctggtgctcc aggtgaagct 1080
ggtccaccag gtccagctgg tgctgaaggt gaagctggtc cagctggtgc tccaggtgaa 1140
ccaggtccag aaggtccacc aggtgaagct ggtgctccag gtccaccagg tgctccaggt 1200
gctgaaggtg aaccaggtcc agaaggtgct ccaggtccac caggtccagc tggtgaacca 1260
ggtccagctg gtgctccagg tccaccaggt gaagctggtc caccaggtga agctggtgct 1320
ccaggtccag aaggtgctga aggtgaagct ggtgaaccag gtccagctgg tgaaccaggt 1380
ccagctggtg ctccaggtga agctggtcca ccaggtccag ctggtgctga aggtgaagct 1440
ggtccagctg gtgctccagg tgaaccaggt ccagaaggtc caccaggtga agctggtgct 1500
ccaggtccac caggtgctcc aggtgctgaa ggtgaaccag gtccagaagg tgctccaggt 1560
ccaccaggtc cagctggtga accaggtcca gctggtgctc caggtccacc aggtgaagct 1620
ggtccaccag gtgaagctgg tgctccaggt ccagaaggtg ctgaaggtga agctggtgaa 1680
ccaggtccag ctggtgaacc aggtccagct ggtgctccag gtgaagctgg tccaccaggt 1740
ccagctggtg ctgaaggtga agctggtcca gctggtgctc caggtgaacc aggtccagaa 1800
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 1860
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 1920
gctccaggtc caccaggtga agctggtcca ccaggtgaag ctggtgctcc aggtccagaa 1980
ggtgctgaag gtgaagctgg tgaaccaggt ccagctggtg aaccaggtcc agctggtgct 2040
ccaggtgaag ctggtccacc aggtccagct ggtgctgaag gtgaagctgg tccagctggt 2100
gctccaggtg aaccaggtcc agaaggtcca ccaggtgaag ctggtgctcc aggtccacca 2160
ggtgctccag gtgctgaagg tgaaccaggt ccagaaggtg ctccaggtcc accaggtcca 2220
gctggtgaac caggtccagc tggtgctcca ggtccaccag gtgaagctgg tccaccaggt 2280
gaagctggtg ctccaggtcc agaaggtgct gaaggtgaag ctggtgaacc aggtccagct 2340
ggtgaaccag gtccagctgg tgctccaggt gaagctggtc caccaggtcc agctggtgct 2400
gaaggtgaag ctggtccagc tggtgctcca ggtgaaccag gtccagaagg tccaccaggt 2460
gaagctggtg ctccaggtcc accaggtgct ccaggtgctg aaggtgaacc aggtccagaa 2520
ggtgctccag gtccaccagg tccagctggt gaaccaggtc cagctggtgc tccaggtcca 2580
ccaggtgaag ctggtttccc aactattcca ttgtctagat tgttcgacaa cgctatgttg 2640
agagcccaca gattgcacca attggctttc gacacttacc aagaattcga agaagcttac 2700
attccaaagg aacagaagta ctctttcttg caaaacccac aaacttcttt gtgtttctct 2760
gaatctattc caactccatc taacagagaa gaaactcaac aaaagtctaa cttggaattg 2820
ttgagaattt ctttgttgtt gattcaatct tggttggaac cagttcaatt cttgagatct 2880
gttttcgcta actctttggt ttacggtgct tctgactcta acgtttacga cttgttgaag 2940
gacttggaag aaggtattca aactttgatg ggtagattgg aagacggttc tcctagaact 3000
ggtcaaattt tcaagcaaac ttactctaag ttcgacacta actctcacaa cgacgacgct 3060
ttgttgaaga actacggttt gttgtactgt ttcagaaagg acatggacaa ggttgaaact 3120
ttcttgagaa ttgttcaatg tagatctgtt gaaggttctt gtggtttcgg tccaccaggt 3180
gaagctggtg ctccaggtcc agaaggtgct gaaggtgaag ctggtgaacc aggtccagct 3240
ggtgaaccag gtccagctgg tgctccaggt gaagctggtc caccaggtcc agctggtgct 3300
gaaggtgaag ctggtccagc tggtgctcca ggtgaaccag gtccagaagg tccaccaggt 3360
gaagctggtg ctccaggtcc accaggtgct ccaggtgctg aaggtgaacc aggtccagaa 3420
ggtgctccag gtccaccagg tccagctggt gaaccaggtc cagctggtgc tccaggtcca 3480
ccaggtgaag ct 3492
<210> 267
<211> 1164
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 267
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
1 5 10 15
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
50 55 60
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
65 70 75 80
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Pro Gly
100 105 110
Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
115 120 125
Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro
130 135 140
Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly
145 150 155 160
Glu Ala Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala
165 170 175
Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu
180 185 190
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala
210 215 220
Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu
225 230 235 240
Gly Pro Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly
245 250 255
Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Glu
260 265 270
Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro
275 280 285
Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly
290 295 300
Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro
305 310 315 320
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
325 330 335
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
340 345 350
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
355 360 365
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Pro Glu
370 375 380
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly
385 390 395 400
Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
405 410 415
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
420 425 430
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
435 440 445
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala
450 455 460
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
465 470 475 480
Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
485 490 495
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
500 505 510
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
515 520 525
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Pro Gly
530 535 540
Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
545 550 555 560
Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro
565 570 575
Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly
580 585 590
Glu Ala Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala
595 600 605
Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu
610 615 620
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
625 630 635 640
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala
645 650 655
Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu
660 665 670
Gly Pro Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly
675 680 685
Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Glu
690 695 700
Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro
705 710 715 720
Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly
725 730 735
Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro
740 745 750
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
755 760 765
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
770 775 780
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
785 790 795 800
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Pro Glu
805 810 815
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly
820 825 830
Ala Glu Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
835 840 845
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
850 855 860
Gly Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu
865 870 875 880
Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe
885 890 895
Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn
900 905 910
Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn
915 920 925
Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser
930 935 940
Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser
945 950 955 960
Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr
965 970 975
Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg
980 985 990
Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr
995 1000 1005
Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn
1010 1015 1020
Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr
1025 1030 1035 1040
Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe
1045 1050 1055
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
1060 1065 1070
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Pro Glu Gly Ala
1075 1080 1085
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
1090 1095 1100
Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
1105 1110 1115 1120
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
1125 1130 1135
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
1140 1145 1150
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
1155 1160
<210> 268
<211> 3492
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 268
ggtccaccag gtgaagctgg tgctccaggt ccagaaggtg ctgaaggtga agctggtgaa 60
ccaggtccag ctggtgaacc aggtccagct ggtgctccag gtgaagctgg tccaccaggt 120
ccagctggtg ctgaaggtga agctggtcca gctggtgctc caggtgaacc aggtccagaa 180
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 240
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 300
gctccaggtc caccaggtga agctggtcca ccaggtgaag ctggtgctcc aggtccagaa 360
ggtgctgaag gtgaagctgg tgaaccaggt ccagctggtg aaccaggtcc agctggtgct 420
ccaggtgaag ctggtccacc aggtccagct ggtgctgaag gtgaagctgg tccagctggt 480
gctccaggtg aaccaggtcc agaaggtcca ccaggtgaag ctggtgctcc aggtccacca 540
ggtgctccag gtgctgaagg tgaaccaggt ccagaaggtg ctccaggtcc accaggtcca 600
gctggtgaac caggtccagc tggtgctcca ggtccaccag gtgaagctgg tccaccaggt 660
gaagctggtg ctccaggtcc agaaggtgct gaaggtgaag ctggtgaacc aggtccagct 720
ggtgaaccag gtccagctgg tgctccaggt gaagctggtc caccaggtcc agctggtgct 780
gaaggtgaag ctggtccagc tggtgctcca ggtgaaccag gtccagaagg tccaccaggt 840
gaagctggtg ctccaggtcc accaggtgct ccaggtgctg aaggtgaacc aggtccagaa 900
ggtgctccag gtccaccagg tccagctggt gaaccaggtc cagctggtgc tccaggtcca 960
ccaggtgaag ctggtccacc aggtgaagct ggtgctccag gtccagaagg tgctgaaggt 1020
gaagctggtg aaccaggtcc agctggtgaa ccaggtccag ctggtgctcc aggtgaagct 1080
ggtccaccag gtccagctgg tgctgaaggt gaagctggtc cagctggtgc tccaggtgaa 1140
ccaggtccag aaggtccacc aggtgaagct ggtgctccag gtccaccagg tgctccaggt 1200
gctgaaggtg aaccaggtcc agaaggtgct ccaggtccac caggtccagc tggtgaacca 1260
ggtccagctg gtgctccagg tccaccaggt gaagctggtc caccaggtga agctggtgct 1320
ccaggtccag aaggtgctga aggtgaagct ggtgaaccag gtccagctgg tgaaccaggt 1380
ccagctggtg ctccaggtga agctggtcca ccaggtccag ctggtgctga aggtgaagct 1440
ggtccagctg gtgctccagg tgaaccaggt ccagaaggtc caccaggtga agctggtgct 1500
ccaggtccac caggtgctcc aggtgctgaa ggtgaaccag gtccagaagg tgctccaggt 1560
ccaccaggtc cagctggtga accaggtcca gctggtgctc caggtccacc aggtgaagct 1620
ggtccaccag gtgaagctgg tgctccaggt ccagaaggtg ctgaaggtga agctggtgaa 1680
ccaggtccag ctggtgaacc aggtccagct ggtgctccag gtgaagctgg tccaccaggt 1740
ccagctggtg ctgaaggtga agctggtcca gctggtgctc caggtgaacc aggtccagaa 1800
ggtccaccag gtgaagctgg tgctccaggt ccaccaggtg ctccaggtgc tgaaggtgaa 1860
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 1920
gctccaggtc caccaggtga agctggtcca ccaggtgaag ctggtgctcc aggtccagaa 1980
ggtgctgaag gtgaagctgg tgaaccaggt ccagctggtg aaccaggtcc agctggtgct 2040
ccaggtgaag ctggtccacc aggtccagct ggtgctgaag gtgaagctgg tccagctggt 2100
gctccaggtg aaccaggtcc agaaggtcca ccaggtgaag ctggtgctcc aggtccacca 2160
ggtgctccag gtgctgaagg tgaaccaggt ccagaaggtg ctccaggtcc accaggtcca 2220
gctggtgaac caggtccagc tggtgctcca ggtccaccag gtgaagctgg tccaccaggt 2280
gaagctggtg ctccaggtcc agaaggtgct gaaggtgaag ctggtgaacc aggtccagct 2340
ggtgaaccag gtccagctgg tgctccaggt gaagctggtc caccaggtcc agctggtgct 2400
gaaggtgaag ctggtccagc tggtgctcca ggtgaaccag gtccagaagg tccaccaggt 2460
gaagctggtg ctccaggtcc accaggtgct ccaggtgctg aaggtgaacc aggtccagaa 2520
ggtgctccag gtccaccagg tccagctggt gaaccaggtc cagctggtgc tccaggtcca 2580
ccaggtgaag ctggttttcc aactattcca ttgtctagat tgtttgataa cgctatgttg 2640
agagctcata gattgcatca attggctttt gatacttacc aagaatttga agaagcttac 2700
attccaaagg aacaaaagta ctcttttttg caaaacccac aaacttcttt gtgtttttct 2760
gaatctattc caactccatc taacagagaa gaaactcaac aaaagtctaa cttggaattg 2820
ttgagaattt ctttgttgtt gattcaatct tggttggaac cagttcaatt tttgagatct 2880
gtttttgcta actctttggt ttacggtgct tctgattcta acgtttacga tttgttgaag 2940
gatttggaag aaggtattca aactttgatg ggtagattgg aagatggttc tccaagaact 3000
ggtcaaattt ttaagcaaac ttactctaag tttgatacta actctcataa cgatgatgct 3060
ttgttgaaga actacggttt gttgtactgt tttagaaagg atatggataa ggttgaaact 3120
tttttgagaa ttgttcaatg tagatctgtt gaaggttctt gtggttttgg tccaccaggt 3180
gaagctggtg ctccaggtcc agaaggtgct gaaggtgaag ctggtgaacc aggtccagct 3240
ggtgaaccag gtccagctgg tgctccaggt gaagctggtc caccaggtcc agctggtgct 3300
gaaggtgaag ctggtccagc tggtgctcca ggtgaaccag gtccagaagg tccaccaggt 3360
gaagctggtg ctccaggtcc accaggtgct ccaggtgctg aaggtgaacc aggtccagaa 3420
ggtgctccag gtccaccagg tccagctggt gaaccaggtc cagctggtgc tccaggtcca 3480
ccaggtgaag ct 3492
<210> 269
<211> 1164
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 269
Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly
1 5 10 15
Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
20 25 30
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
35 40 45
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
50 55 60
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
65 70 75 80
Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
85 90 95
Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Ala Pro Gly
100 105 110
Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu
115 120 125
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
130 135 140
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu
165 170 175
Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro
180 185 190
Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly
195 200 205
Glu Pro Gly Ala Pro Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly Ala
210 215 220
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
225 230 235 240
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
245 250 255
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
260 265 270
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
275 280 285
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
290 295 300
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
305 310 315 320
Pro Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala
325 330 335
Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly
340 345 350
Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro
355 360 365
Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro
370 375 380
Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly
385 390 395 400
Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro
405 410 415
Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro
420 425 430
Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly
435 440 445
Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
450 455 460
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
465 470 475 480
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
485 490 495
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
500 505 510
Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
515 520 525
Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Ala Pro Gly
530 535 540
Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu
545 550 555 560
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
565 570 575
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly
580 585 590
Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu
595 600 605
Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro
610 615 620
Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly
625 630 635 640
Glu Pro Gly Ala Pro Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly Ala
645 650 655
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
660 665 670
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
675 680 685
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
690 695 700
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
705 710 715 720
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
725 730 735
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
740 745 750
Pro Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala
755 760 765
Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly
770 775 780
Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro
785 790 795 800
Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro
805 810 815
Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly
820 825 830
Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro
835 840 845
Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro
850 855 860
Gly Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu
865 870 875 880
Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe
885 890 895
Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn
900 905 910
Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn
915 920 925
Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser
930 935 940
Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser
945 950 955 960
Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr
965 970 975
Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg
980 985 990
Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr
995 1000 1005
Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn
1010 1015 1020
Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr
1025 1030 1035 1040
Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe
1045 1050 1055
Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly
1060 1065 1070
Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
1075 1080 1085
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
1090 1095 1100
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
1105 1110 1115 1120
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
1125 1130 1135
Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
1140 1145 1150
Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro
1155 1160
<210> 270
<211> 3492
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 270
ggtgctccag gtccagaagg tgctgaaggt gaagctggtg aaccaggtcc agctggtgaa 60
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 120
gctccaggtc caccaggtga agctggtcca gctggtgctc caggtgaagc tggtccacca 180
ggtccagctg gtgctgaagg tgaagctggt ccagctggtg ctccaggtga accaggtcca 240
gaaggtccac caggtgaagc tggtgctcca ggtccaccag gtgctccagg tgctgaaggt 300
gaaccaggtg ctccaggtga accaggtgct ccaggtccag aaggtgctga aggtgaagct 360
ggtgaaccag gtccagctgg tgaaccaggt ccagaaggtg ctccaggtcc accaggtcca 420
gctggtgaac caggtccagc tggtgctcca ggtccaccag gtgaagctgg tccagctggt 480
gctccaggtg aagctggtcc accaggtcca gctggtgctg aaggtgaagc tggtccagct 540
ggtgctccag gtgaaccagg tccagaaggt ccaccaggtg aagctggtgc tccaggtcca 600
ccaggtgctc caggtgctga aggtgaacca ggtgctccag gtgaaccagg tgctccaggt 660
ccagaaggtg ctgaaggtga agctggtgaa ccaggtccag ctggtgaacc aggtccagaa 720
ggtgctccag gtccaccagg tccagctggt gaaccaggtc cagctggtgc tccaggtcca 780
ccaggtgaag ctggtccagc tggtgctcca ggtgaagctg gtccaccagg tccagctggt 840
gctgaaggtg aagctggtcc agctggtgct ccaggtgaac caggtccaga aggtccacca 900
ggtgaagctg gtgctccagg tccaccaggt gctccaggtg ctgaaggtga accaggtgct 960
ccaggtgaac caggtgctcc aggtccagaa ggtgctgaag gtgaagctgg tgaaccaggt 1020
ccagctggtg aaccaggtcc agaaggtgct ccaggtccac caggtccagc tggtgaacca 1080
ggtccagctg gtgctccagg tccaccaggt gaagctggtc cagctggtgc tccaggtgaa 1140
gctggtccac caggtccagc tggtgctgaa ggtgaagctg gtccagctgg tgctccaggt 1200
gaaccaggtc cagaaggtcc accaggtgaa gctggtgctc caggtccacc aggtgctcca 1260
ggtgctgaag gtgaaccagg tgctccaggt gaaccaggtg ctccaggtcc agaaggtgct 1320
gaaggtgaag ctggtgaacc aggtccagct ggtgaaccag gtccagaagg tgctccaggt 1380
ccaccaggtc cagctggtga accaggtcca gctggtgctc caggtccacc aggtgaagct 1440
ggtccagctg gtgctccagg tgaagctggt ccaccaggtc cagctggtgc tgaaggtgaa 1500
gctggtccag ctggtgctcc aggtgaacca ggtccagaag gtccaccagg tgaagctggt 1560
gctccaggtc caccaggtgc tccaggtgct gaaggtgaac caggtgctcc aggtgaacca 1620
ggtgctccag gtccagaagg tgctgaaggt gaagctggtg aaccaggtcc agctggtgaa 1680
ccaggtccag aaggtgctcc aggtccacca ggtccagctg gtgaaccagg tccagctggt 1740
gctccaggtc caccaggtga agctggtcca gctggtgctc caggtgaagc tggtccacca 1800
ggtccagctg gtgctgaagg tgaagctggt ccagctggtg ctccaggtga accaggtcca 1860
gaaggtccac caggtgaagc tggtgctcca ggtccaccag gtgctccagg tgctgaaggt 1920
gaaccaggtg ctccaggtga accaggtgct ccaggtccag aaggtgctga aggtgaagct 1980
ggtgaaccag gtccagctgg tgaaccaggt ccagaaggtg ctccaggtcc accaggtcca 2040
gctggtgaac caggtccagc tggtgctcca ggtccaccag gtgaagctgg tccagctggt 2100
gctccaggtg aagctggtcc accaggtcca gctggtgctg aaggtgaagc tggtccagct 2160
ggtgctccag gtgaaccagg tccagaaggt ccaccaggtg aagctggtgc tccaggtcca 2220
ccaggtgctc caggtgctga aggtgaacca ggtgctccag gtgaaccagg tgctccaggt 2280
ccagaaggtg ctgaaggtga agctggtgaa ccaggtccag ctggtgaacc aggtccagaa 2340
ggtgctccag gtccaccagg tccagctggt gaaccaggtc cagctggtgc tccaggtcca 2400
ccaggtgaag ctggtccagc tggtgctcca ggtgaagctg gtccaccagg tccagctggt 2460
gctgaaggtg aagctggtcc agctggtgct ccaggtgaac caggtccaga aggtccacca 2520
ggtgaagctg gtgctccagg tccaccaggt gctccaggtg ctgaaggtga accaggtgct 2580
ccaggtgaac caggttttcc aactattcca ttgtctagat tgtttgataa cgctatgttg 2640
agagctcata gattgcatca attggctttt gatacttacc aagaatttga agaagcttac 2700
attccaaagg aacaaaagta ctcttttttg caaaacccac aaacttcttt gtgtttttct 2760
gaatctattc caactccatc taacagagaa gaaactcaac aaaagtctaa cttggaattg 2820
ttgagaattt ctttgttgtt gattcaatct tggttggaac cagttcaatt tttgagatct 2880
gtttttgcta actctttggt ttacggtgct tctgattcta acgtttacga tttgttgaag 2940
gatttggaag aaggtattca aactttgatg ggtagattgg aagatggttc tccaagaact 3000
ggtcaaattt ttaagcaaac ttactctaag tttgatacta actctcataa cgatgatgct 3060
ttgttgaaga actacggttt gttgtactgt tttagaaagg atatggataa ggttgaaact 3120
tttttgagaa ttgttcaatg tagatctgtt gaaggttctt gtggttttgg tgctccaggt 3180
ccagaaggtg ctgaaggtga agctggtgaa ccaggtccag ctggtgaacc aggtccagaa 3240
ggtgctccag gtccaccagg tccagctggt gaaccaggtc cagctggtgc tccaggtcca 3300
ccaggtgaag ctggtccagc tggtgctcca ggtgaagctg gtccaccagg tccagctggt 3360
gctgaaggtg aagctggtcc agctggtgct ccaggtgaac caggtccaga aggtccacca 3420
ggtgaagctg gtgctccagg tccaccaggt gctccaggtg ctgaaggtga accaggtgct 3480
ccaggtgaac ca 3492
<210> 271
<211> 1164
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 271
Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Glu Glu Gly Pro Glu Gly
1 5 10 15
Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Ala
20 25 30
Glu Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Ala Pro
35 40 45
Gly Pro Glu Gly Ala Ala Gly Pro Pro Gly Ala Glu Gly Glu Ala Gly
50 55 60
Glu Ala Gly Glu Ala Gly Pro Ala Gly Glu Glu Gly Pro Pro Gly Ala
65 70 75 80
Pro Gly Pro Pro Gly Glu Ala Gly Glu Glu Gly Ala Pro Gly Ala Glu
85 90 95
Gly Glu Ala Gly Pro Pro Gly Ala Glu Gly Pro Ala Gly Glu Pro Gly
100 105 110
Pro Glu Gly Ala Ala Gly Glu Glu Gly Pro Glu Gly Ala Glu Gly Pro
115 120 125
Ala Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Ala Glu Gly Glu Glu
130 135 140
Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly
145 150 155 160
Ala Ala Gly Pro Pro Gly Ala Glu Gly Glu Ala Gly Glu Ala Gly Glu
165 170 175
Ala Gly Pro Ala Gly Glu Glu Gly Pro Pro Gly Ala Pro Gly Pro Pro
180 185 190
Gly Glu Ala Gly Glu Glu Gly Ala Pro Gly Ala Glu Gly Glu Ala Gly
195 200 205
Pro Pro Gly Ala Glu Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
210 215 220
Ala Gly Glu Glu Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly Pro Ala
225 230 235 240
Gly Ala Pro Gly Ala Pro Gly Ala Glu Gly Glu Glu Gly Pro Pro Gly
245 250 255
Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly Ala Ala Gly Pro
260 265 270
Pro Gly Ala Glu Gly Glu Ala Gly Glu Ala Gly Glu Ala Gly Pro Ala
275 280 285
Gly Glu Glu Gly Pro Pro Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly
290 295 300
Glu Glu Gly Ala Pro Gly Ala Glu Gly Glu Ala Gly Pro Pro Gly Ala
305 310 315 320
Glu Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Glu Glu
325 330 335
Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro Gly
340 345 350
Ala Pro Gly Ala Glu Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Glu
355 360 365
Pro Gly Ala Pro Gly Pro Glu Gly Ala Ala Gly Pro Pro Gly Ala Glu
370 375 380
Gly Glu Ala Gly Glu Ala Gly Glu Ala Gly Pro Ala Gly Glu Glu Gly
385 390 395 400
Pro Pro Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Glu Glu Gly Ala
405 410 415
Pro Gly Ala Glu Gly Glu Ala Gly Pro Pro Gly Ala Glu Gly Pro Ala
420 425 430
Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Glu Glu Gly Pro Glu Gly
435 440 445
Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Ala
450 455 460
Glu Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Ala Pro
465 470 475 480
Gly Pro Glu Gly Ala Ala Gly Pro Pro Gly Ala Glu Gly Glu Ala Gly
485 490 495
Glu Ala Gly Glu Ala Gly Pro Ala Gly Glu Glu Gly Pro Pro Gly Ala
500 505 510
Pro Gly Pro Pro Gly Glu Ala Gly Glu Glu Gly Ala Pro Gly Ala Glu
515 520 525
Gly Glu Ala Gly Pro Pro Gly Ala Glu Gly Pro Ala Gly Glu Pro Gly
530 535 540
Pro Glu Gly Ala Ala Gly Glu Glu Gly Pro Glu Gly Ala Glu Gly Pro
545 550 555 560
Ala Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Ala Glu Gly Glu Glu
565 570 575
Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly
580 585 590
Ala Ala Gly Pro Pro Gly Ala Glu Gly Glu Ala Gly Glu Ala Gly Glu
595 600 605
Ala Gly Pro Ala Gly Glu Glu Gly Pro Pro Gly Ala Pro Gly Pro Pro
610 615 620
Gly Glu Ala Gly Glu Glu Gly Ala Pro Gly Ala Glu Gly Glu Ala Gly
625 630 635 640
Pro Pro Gly Ala Glu Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
645 650 655
Ala Gly Glu Glu Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly Pro Ala
660 665 670
Gly Ala Pro Gly Ala Pro Gly Ala Glu Gly Glu Glu Gly Pro Pro Gly
675 680 685
Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro Glu Gly Ala Ala Gly Pro
690 695 700
Pro Gly Ala Glu Gly Glu Ala Gly Glu Ala Gly Glu Ala Gly Pro Ala
705 710 715 720
Gly Glu Glu Gly Pro Pro Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly
725 730 735
Glu Glu Gly Ala Pro Gly Ala Glu Gly Glu Ala Gly Pro Pro Gly Ala
740 745 750
Glu Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Glu Glu
755 760 765
Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro Gly
770 775 780
Ala Pro Gly Ala Glu Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Glu
785 790 795 800
Pro Gly Ala Pro Gly Pro Glu Gly Ala Ala Gly Pro Pro Gly Ala Glu
805 810 815
Gly Glu Ala Gly Glu Ala Gly Glu Ala Gly Pro Ala Gly Glu Glu Gly
820 825 830
Pro Pro Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Glu Glu Gly Ala
835 840 845
Pro Gly Ala Glu Gly Glu Ala Gly Pro Pro Gly Ala Glu Gly Pro Ala
850 855 860
Gly Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu
865 870 875 880
Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe
885 890 895
Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn
900 905 910
Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn
915 920 925
Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser
930 935 940
Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser
945 950 955 960
Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr
965 970 975
Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg
980 985 990
Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr
995 1000 1005
Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn
1010 1015 1020
Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr
1025 1030 1035 1040
Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe
1045 1050 1055
Gly Glu Pro Gly Pro Glu Gly Ala Ala Gly Glu Glu Gly Pro Glu Gly
1060 1065 1070
Ala Glu Gly Pro Ala Gly Pro Ala Gly Ala Pro Gly Ala Pro Gly Ala
1075 1080 1085
Glu Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Glu Pro Gly Ala Pro
1090 1095 1100
Gly Pro Glu Gly Ala Ala Gly Pro Pro Gly Ala Glu Gly Glu Ala Gly
1105 1110 1115 1120
Glu Ala Gly Glu Ala Gly Pro Ala Gly Glu Glu Gly Pro Pro Gly Ala
1125 1130 1135
Pro Gly Pro Pro Gly Glu Ala Gly Glu Glu Gly Ala Pro Gly Ala Glu
1140 1145 1150
Gly Glu Ala Gly Pro Pro Gly Ala Glu Gly Pro Ala
1155 1160
<210> 272
<211> 3492
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 272
ggtgaaccag gtccagaagg tgctgctggt gaagaaggtc cagaaggtgc tgaaggtcca 60
gctggtccag ctggtgctcc aggtgctcca ggtgctgaag gtgaagaagg tccaccaggt 120
gaagctggtg aaccaggtgc tccaggtcca gaaggtgctg ctggtccacc aggtgctgaa 180
ggtgaagctg gtgaagctgg tgaagctggt ccagctggtg aagaaggtcc accaggtgct 240
ccaggtccac caggtgaagc tggtgaagaa ggtgctccag gtgctgaagg tgaagctggt 300
ccaccaggtg ctgaaggtcc agctggtgaa ccaggtccag aaggtgctgc tggtgaagaa 360
ggtccagaag gtgctgaagg tccagctggt ccagctggtg ctccaggtgc tccaggtgct 420
gaaggtgaag aaggtccacc aggtgaagct ggtgaaccag gtgctccagg tccagaaggt 480
gctgctggtc caccaggtgc tgaaggtgaa gctggtgaag ctggtgaagc tggtccagct 540
ggtgaagaag gtccaccagg tgctccaggt ccaccaggtg aagctggtga agaaggtgct 600
ccaggtgctg aaggtgaagc tggtccacca ggtgctgaag gtccagctgg tgaaccaggt 660
ccagaaggtg ctgctggtga agaaggtcca gaaggtgctg aaggtccagc tggtccagct 720
ggtgctccag gtgctccagg tgctgaaggt gaagaaggtc caccaggtga agctggtgaa 780
ccaggtgctc caggtccaga aggtgctgct ggtccaccag gtgctgaagg tgaagctggt 840
gaagctggtg aagctggtcc agctggtgaa gaaggtccac caggtgctcc aggtccacca 900
ggtgaagctg gtgaagaagg tgctccaggt gctgaaggtg aagctggtcc accaggtgct 960
gaaggtccag ctggtgaacc aggtccagaa ggtgctgctg gtgaagaagg tccagaaggt 1020
gctgaaggtc cagctggtcc agctggtgct ccaggtgctc caggtgctga aggtgaagaa 1080
ggtccaccag gtgaagctgg tgaaccaggt gctccaggtc cagaaggtgc tgctggtcca 1140
ccaggtgctg aaggtgaagc tggtgaagct ggtgaagctg gtccagctgg tgaagaaggt 1200
ccaccaggtg ctccaggtcc accaggtgaa gctggtgaag aaggtgctcc aggtgctgaa 1260
ggtgaagctg gtccaccagg tgctgaaggt ccagctggtg aaccaggtcc agaaggtgct 1320
gctggtgaag aaggtccaga aggtgctgaa ggtccagctg gtccagctgg tgctccaggt 1380
gctccaggtg ctgaaggtga agaaggtcca ccaggtgaag ctggtgaacc aggtgctcca 1440
ggtccagaag gtgctgctgg tccaccaggt gctgaaggtg aagctggtga agctggtgaa 1500
gctggtccag ctggtgaaga aggtccacca ggtgctccag gtccaccagg tgaagctggt 1560
gaagaaggtg ctccaggtgc tgaaggtgaa gctggtccac caggtgctga aggtccagct 1620
ggtgaaccag gtccagaagg tgctgctggt gaagaaggtc cagaaggtgc tgaaggtcca 1680
gctggtccag ctggtgctcc aggtgctcca ggtgctgaag gtgaagaagg tccaccaggt 1740
gaagctggtg aaccaggtgc tccaggtcca gaaggtgctg ctggtccacc aggtgctgaa 1800
ggtgaagctg gtgaagctgg tgaagctggt ccagctggtg aagaaggtcc accaggtgct 1860
ccaggtccac caggtgaagc tggtgaagaa ggtgctccag gtgctgaagg tgaagctggt 1920
ccaccaggtg ctgaaggtcc agctggtgaa ccaggtccag aaggtgctgc tggtgaagaa 1980
ggtccagaag gtgctgaagg tccagctggt ccagctggtg ctccaggtgc tccaggtgct 2040
gaaggtgaag aaggtccacc aggtgaagct ggtgaaccag gtgctccagg tccagaaggt 2100
gctgctggtc caccaggtgc tgaaggtgaa gctggtgaag ctggtgaagc tggtccagct 2160
ggtgaagaag gtccaccagg tgctccaggt ccaccaggtg aagctggtga agaaggtgct 2220
ccaggtgctg aaggtgaagc tggtccacca ggtgctgaag gtccagctgg tgaaccaggt 2280
ccagaaggtg ctgctggtga agaaggtcca gaaggtgctg aaggtccagc tggtccagct 2340
ggtgctccag gtgctccagg tgctgaaggt gaagaaggtc caccaggtga agctggtgaa 2400
ccaggtgctc caggtccaga aggtgctgct ggtccaccag gtgctgaagg tgaagctggt 2460
gaagctggtg aagctggtcc agctggtgaa gaaggtccac caggtgctcc aggtccacca 2520
ggtgaagctg gtgaagaagg tgctccaggt gctgaaggtg aagctggtcc accaggtgct 2580
gaaggtccag ctggttttcc aactattcca ttgtctagat tgtttgataa cgctatgttg 2640
agagctcata gattgcatca attggctttt gatacttacc aagaatttga agaagcttac 2700
attccaaagg aacaaaagta ctcttttttg caaaacccac aaacttcttt gtgtttttct 2760
gaatctattc caactccatc taacagagaa gaaactcaac aaaagtctaa cttggaattg 2820
ttgagaattt ctttgttgtt gattcaatct tggttggaac cagttcaatt tttgagatct 2880
gtttttgcta actctttggt ttacggtgct tctgattcta acgtttacga tttgttgaag 2940
gatttggaag aaggtattca aactttgatg ggtagattgg aagatggttc tccaagaact 3000
ggtcaaattt ttaagcaaac ttactctaag tttgatacta actctcataa cgatgatgct 3060
ttgttgaaga actacggttt gttgtactgt tttagaaagg atatggataa ggttgaaact 3120
tttttgagaa ttgttcaatg tagatctgtt gaaggttctt gtggttttgg tgaaccaggt 3180
ccagaaggtg ctgctggtga agaaggtcca gaaggtgctg aaggtccagc tggtccagct 3240
ggtgctccag gtgctccagg tgctgaaggt gaagaaggtc caccaggtga agctggtgaa 3300
ccaggtgctc caggtccaga aggtgctgct ggtccaccag gtgctgaagg tgaagctggt 3360
gaagctggtg aagctggtcc agctggtgaa gaaggtccac caggtgctcc aggtccacca 3420
ggtgaagctg gtgaagaagg tgctccaggt gctgaaggtg aagctggtcc accaggtgct 3480
gaaggtccag ct 3492
<210> 273
<211> 1164
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 273
Gly Ala Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly
1 5 10 15
Pro Pro Gly Glu Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly Glu
20 25 30
Pro Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Glu Ala Gly Ala Glu
35 40 45
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Ala Gly Pro Pro Gly Glu Glu Gly Pro Glu Gly Ala Pro Gly Ala
65 70 75 80
Glu Gly Pro Pro Gly Ala Ala Gly Glu Glu Gly Pro Ala Gly Ala Pro
85 90 95
Gly Glu Pro Gly Ala Ala Gly Glu Glu Gly Pro Glu Gly Ala Glu Gly
100 105 110
Pro Pro Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly Pro Pro Gly Glu
115 120 125
Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Ala Glu
130 135 140
Gly Pro Ala Gly Pro Ala Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly
145 150 155 160
Pro Pro Gly Glu Ala Gly Ala Pro Gly Glu Ala Gly Pro Ala Gly Pro
165 170 175
Pro Gly Glu Glu Gly Pro Glu Gly Ala Pro Gly Ala Glu Gly Pro Pro
180 185 190
Gly Ala Ala Gly Glu Glu Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly
195 200 205
Ala Ala Gly Glu Glu Gly Pro Glu Gly Ala Glu Gly Pro Pro Gly Pro
210 215 220
Glu Gly Ala Glu Gly Pro Ala Gly Pro Pro Gly Glu Glu Gly Ala Ala
225 230 235 240
Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Ala Glu Gly Pro Ala Gly
245 250 255
Pro Ala Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Pro Gly Glu
260 265 270
Ala Gly Ala Pro Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly Glu Glu
275 280 285
Gly Pro Glu Gly Ala Pro Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly
290 295 300
Glu Glu Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Ala Ala Gly Glu
305 310 315 320
Glu Gly Pro Glu Gly Ala Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu
325 330 335
Gly Pro Ala Gly Pro Pro Gly Glu Glu Gly Ala Ala Gly Ala Glu Gly
340 345 350
Glu Glu Gly Glu Pro Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Glu
355 360 365
Ala Gly Ala Glu Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro
370 375 380
Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly Glu Glu Gly Pro Glu Gly
385 390 395 400
Ala Pro Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly Glu Glu Gly Pro
405 410 415
Ala Gly Ala Pro Gly Glu Pro Gly Ala Ala Gly Glu Glu Gly Pro Glu
420 425 430
Gly Ala Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly
435 440 445
Pro Pro Gly Glu Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly Glu
450 455 460
Pro Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Glu Ala Gly Ala Glu
465 470 475 480
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Glu Ala Gly
485 490 495
Pro Ala Gly Pro Pro Gly Glu Glu Gly Pro Glu Gly Ala Pro Gly Ala
500 505 510
Glu Gly Pro Pro Gly Ala Ala Gly Glu Glu Gly Pro Ala Gly Ala Pro
515 520 525
Gly Glu Pro Gly Ala Ala Gly Glu Glu Gly Pro Glu Gly Ala Glu Gly
530 535 540
Pro Pro Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly Pro Pro Gly Glu
545 550 555 560
Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Ala Glu
565 570 575
Gly Pro Ala Gly Pro Ala Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly
580 585 590
Pro Pro Gly Glu Ala Gly Ala Pro Gly Glu Ala Gly Pro Ala Gly Pro
595 600 605
Pro Gly Glu Glu Gly Pro Glu Gly Ala Pro Gly Ala Glu Gly Pro Pro
610 615 620
Gly Ala Ala Gly Glu Glu Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly
625 630 635 640
Ala Ala Gly Glu Glu Gly Pro Glu Gly Ala Glu Gly Pro Pro Gly Pro
645 650 655
Glu Gly Ala Glu Gly Pro Ala Gly Pro Pro Gly Glu Glu Gly Ala Ala
660 665 670
Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Ala Glu Gly Pro Ala Gly
675 680 685
Pro Ala Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Pro Gly Glu
690 695 700
Ala Gly Ala Pro Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly Glu Glu
705 710 715 720
Gly Pro Glu Gly Ala Pro Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly
725 730 735
Glu Glu Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Ala Ala Gly Glu
740 745 750
Glu Gly Pro Glu Gly Ala Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu
755 760 765
Gly Pro Ala Gly Pro Pro Gly Glu Glu Gly Ala Ala Gly Ala Glu Gly
770 775 780
Glu Glu Gly Glu Pro Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Glu
785 790 795 800
Ala Gly Ala Glu Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro
805 810 815
Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly Glu Glu Gly Pro Glu Gly
820 825 830
Ala Pro Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly Glu Glu Gly Pro
835 840 845
Ala Gly Ala Pro Gly Glu Pro Gly Ala Ala Gly Glu Glu Gly Pro Glu
850 855 860
Gly Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu
865 870 875 880
Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe
885 890 895
Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn
900 905 910
Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn
915 920 925
Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser
930 935 940
Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser
945 950 955 960
Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr
965 970 975
Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg
980 985 990
Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr
995 1000 1005
Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn
1010 1015 1020
Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr
1025 1030 1035 1040
Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe
1045 1050 1055
Gly Ala Glu Gly Pro Pro Gly Pro Glu Gly Ala Glu Gly Pro Ala Gly
1060 1065 1070
Pro Pro Gly Glu Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly Glu
1075 1080 1085
Pro Gly Ala Glu Gly Pro Ala Gly Pro Ala Gly Glu Ala Gly Ala Glu
1090 1095 1100
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Glu Ala Gly
1105 1110 1115 1120
Pro Ala Gly Pro Pro Gly Glu Glu Gly Pro Glu Gly Ala Pro Gly Ala
1125 1130 1135
Glu Gly Pro Pro Gly Ala Ala Gly Glu Glu Gly Pro Ala Gly Ala Pro
1140 1145 1150
Gly Glu Pro Gly Ala Ala Gly Glu Glu Gly Pro Glu
1155 1160
<210> 274
<211> 3492
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 274
ggtgctgaag gtccaccagg tccagaaggt gctgaaggtc cagctggtcc accaggtgaa 60
gaaggtgctg ctggtgctga aggtgaagaa ggtgaaccag gtgctgaagg tccagctggt 120
ccagctggtg aagctggtgc tgaaggtgct ccaggtccac caggtgaagc tggtgctcca 180
ggtgaagctg gtccagctgg tccaccaggt gaagaaggtc cagaaggtgc tccaggtgct 240
gaaggtccac caggtgctgc tggtgaagaa ggtccagctg gtgctccagg tgaaccaggt 300
gctgctggtg aagaaggtcc agaaggtgct gaaggtccac caggtccaga aggtgctgaa 360
ggtccagctg gtccaccagg tgaagaaggt gctgctggtg ctgaaggtga agaaggtgaa 420
ccaggtgctg aaggtccagc tggtccagct ggtgaagctg gtgctgaagg tgctccaggt 480
ccaccaggtg aagctggtgc tccaggtgaa gctggtccag ctggtccacc aggtgaagaa 540
ggtccagaag gtgctccagg tgctgaaggt ccaccaggtg ctgctggtga agaaggtcca 600
gctggtgctc caggtgaacc aggtgctgct ggtgaagaag gtccagaagg tgctgaaggt 660
ccaccaggtc cagaaggtgc tgaaggtcca gctggtccac caggtgaaga aggtgctgct 720
ggtgctgaag gtgaagaagg tgaaccaggt gctgaaggtc cagctggtcc agctggtgaa 780
gctggtgctg aaggtgctcc aggtccacca ggtgaagctg gtgctccagg tgaagctggt 840
ccagctggtc caccaggtga agaaggtcca gaaggtgctc caggtgctga aggtccacca 900
ggtgctgctg gtgaagaagg tccagctggt gctccaggtg aaccaggtgc tgctggtgaa 960
gaaggtccag aaggtgctga aggtccacca ggtccagaag gtgctgaagg tccagctggt 1020
ccaccaggtg aagaaggtgc tgctggtgct gaaggtgaag aaggtgaacc aggtgctgaa 1080
ggtccagctg gtccagctgg tgaagctggt gctgaaggtg ctccaggtcc accaggtgaa 1140
gctggtgctc caggtgaagc tggtccagct ggtccaccag gtgaagaagg tccagaaggt 1200
gctccaggtg ctgaaggtcc accaggtgct gctggtgaag aaggtccagc tggtgctcca 1260
ggtgaaccag gtgctgctgg tgaagaaggt ccagaaggtg ctgaaggtcc accaggtcca 1320
gaaggtgctg aaggtccagc tggtccacca ggtgaagaag gtgctgctgg tgctgaaggt 1380
gaagaaggtg aaccaggtgc tgaaggtcca gctggtccag ctggtgaagc tggtgctgaa 1440
ggtgctccag gtccaccagg tgaagctggt gctccaggtg aagctggtcc agctggtcca 1500
ccaggtgaag aaggtccaga aggtgctcca ggtgctgaag gtccaccagg tgctgctggt 1560
gaagaaggtc cagctggtgc tccaggtgaa ccaggtgctg ctggtgaaga aggtccagaa 1620
ggtgctgaag gtccaccagg tccagaaggt gctgaaggtc cagctggtcc accaggtgaa 1680
gaaggtgctg ctggtgctga aggtgaagaa ggtgaaccag gtgctgaagg tccagctggt 1740
ccagctggtg aagctggtgc tgaaggtgct ccaggtccac caggtgaagc tggtgctcca 1800
ggtgaagctg gtccagctgg tccaccaggt gaagaaggtc cagaaggtgc tccaggtgct 1860
gaaggtccac caggtgctgc tggtgaagaa ggtccagctg gtgctccagg tgaaccaggt 1920
gctgctggtg aagaaggtcc agaaggtgct gaaggtccac caggtccaga aggtgctgaa 1980
ggtccagctg gtccaccagg tgaagaaggt gctgctggtg ctgaaggtga agaaggtgaa 2040
ccaggtgctg aaggtccagc tggtccagct ggtgaagctg gtgctgaagg tgctccaggt 2100
ccaccaggtg aagctggtgc tccaggtgaa gctggtccag ctggtccacc aggtgaagaa 2160
ggtccagaag gtgctccagg tgctgaaggt ccaccaggtg ctgctggtga agaaggtcca 2220
gctggtgctc caggtgaacc aggtgctgct ggtgaagaag gtccagaagg tgctgaaggt 2280
ccaccaggtc cagaaggtgc tgaaggtcca gctggtccac caggtgaaga aggtgctgct 2340
ggtgctgaag gtgaagaagg tgaaccaggt gctgaaggtc cagctggtcc agctggtgaa 2400
gctggtgctg aaggtgctcc aggtccacca ggtgaagctg gtgctccagg tgaagctggt 2460
ccagctggtc caccaggtga agaaggtcca gaaggtgctc caggtgctga aggtccacca 2520
ggtgctgctg gtgaagaagg tccagctggt gctccaggtg aaccaggtgc tgctggtgaa 2580
gaaggtccag aaggttttcc aactattcca ttgtctagat tgtttgataa cgctatgttg 2640
agagctcata gattgcatca attggctttt gatacttacc aagaatttga agaagcttac 2700
attccaaagg aacaaaagta ctcttttttg caaaacccac aaacttcttt gtgtttttct 2760
gaatctattc caactccatc taacagagaa gaaactcaac aaaagtctaa cttggaattg 2820
ttgagaattt ctttgttgtt gattcaatct tggttggaac cagttcaatt tttgagatct 2880
gtttttgcta actctttggt ttacggtgct tctgattcta acgtttacga tttgttgaag 2940
gatttggaag aaggtattca aactttgatg ggtagattgg aagatggttc tccaagaact 3000
ggtcaaattt ttaagcaaac ttactctaag tttgatacta actctcataa cgatgatgct 3060
ttgttgaaga actacggttt gttgtactgt tttagaaagg atatggataa ggttgaaact 3120
tttttgagaa ttgttcaatg tagatctgtt gaaggttctt gtggttttgg tgctgaaggt 3180
ccaccaggtc cagaaggtgc tgaaggtcca gctggtccac caggtgaaga aggtgctgct 3240
ggtgctgaag gtgaagaagg tgaaccaggt gctgaaggtc cagctggtcc agctggtgaa 3300
gctggtgctg aaggtgctcc aggtccacca ggtgaagctg gtgctccagg tgaagctggt 3360
ccagctggtc caccaggtga agaaggtcca gaaggtgctc caggtgctga aggtccacca 3420
ggtgctgctg gtgaagaagg tccagctggt gctccaggtg aaccaggtgc tgctggtgaa 3480
gaaggtccag aa 3492
<210> 275
<211> 1225
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 275
Gly Pro Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly
1 5 10 15
Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala
20 25 30
Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala
35 40 45
Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly
50 55 60
Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Pro
65 70 75 80
Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Glu Pro Gly Ala Pro
85 90 95
Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly
100 105 110
Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro
115 120 125
Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala
130 135 140
Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly
145 150 155 160
Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu
165 170 175
Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro
180 185 190
Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Glu Pro Gly
195 200 205
Ala Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro
210 215 220
Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala
225 230 235 240
Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly
245 250 255
Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala
260 265 270
Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro
275 280 285
Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly
290 295 300
Ala Pro Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Glu
305 310 315 320
Pro Gly Ala Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Ala Pro
325 330 335
Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly
340 345 350
Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro
355 360 365
Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro
370 375 380
Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly
385 390 395 400
Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu
405 410 415
Pro Gly Ala Pro Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala
420 425 430
Gly Glu Pro Gly Ala Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly
435 440 445
Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu
450 455 460
Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala
465 470 475 480
Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly
485 490 495
Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro
500 505 510
Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala
515 520 525
Gly Glu Pro Gly Ala Pro Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly
530 535 540
Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro Ala Gly Glu Ala Gly Pro
545 550 555 560
Pro Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro
565 570 575
Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly
580 585 590
Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu
595 600 605
Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro
610 615 620
Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly
625 630 635 640
Pro Ala Gly Glu Pro Gly Ala Pro Gly Pro Pro Gly Glu Pro Gly Pro
645 650 655
Ala Gly Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro Ala Gly Glu Ala
660 665 670
Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly
675 680 685
Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala
690 695 700
Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro
705 710 715 720
Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly
725 730 735
Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala
740 745 750
Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Pro Pro Gly Glu Pro
755 760 765
Gly Pro Ala Gly Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro Ala Gly
770 775 780
Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro
785 790 795 800
Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu
805 810 815
Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly
820 825 830
Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala
835 840 845
Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu
850 855 860
Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Pro Pro Gly
865 870 875 880
Glu Pro Gly Pro Ala Gly Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro
885 890 895
Ala Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Pro
900 905 910
Gly Pro Ala Gly Gly Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp
915 920 925
Asn Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr
930 935 940
Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser
945 950 955 960
Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro
965 970 975
Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu
980 985 990
Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln
995 1000 1005
Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp
1010 1015 1020
Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr
1025 1030 1035 1040
Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe
1045 1050 1055
Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala
1060 1065 1070
Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp
1075 1080 1085
Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly
1090 1095 1100
Ser Cys Gly Phe Gly Pro Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala
1105 1110 1115 1120
Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly
1125 1130 1135
Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala
1140 1145 1150
Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro
1155 1160 1165
Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly
1170 1175 1180
Ala Pro Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Glu
1185 1190 1195 1200
Pro Gly Ala Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Ala Pro
1205 1210 1215
Gly Pro Ala Gly Pro Pro Gly Pro Ala
1220 1225
<210> 276
<211> 3675
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 276
ggtccacctg gtgctccagg tgaaccaggt ccagctggtc caccaggtgc tgaaggtgct 60
ccaggtccag ctggtccaga aggtgaagct ggtgctgaag gtgaaccagg tgaagctggt 120
ccaccaggtg ctccaggtga agctggtgct gaaggtgctc caggtccaga aggtgaacca 180
ggtgaagctg gtccagaagg tgctccaggt ccagctggtg aaccaggtgc tccaggtcca 240
ccaggtgaac caggtccagc tggtgaagct ggtgaaccag gtgctccagg tccagctggt 300
gaagctggtc caccaggtgc tccaggtcca gctggtccac caggtccagc tggtgctcca 360
ggtgaaccag gtccagctgg tccaccaggt gctgaaggtg ctccaggtcc agctggtcca 420
gaaggtgaag ctggtgctga aggtgaacca ggtgaagctg gtccaccagg tgctccaggt 480
gaagctggtg ctgaaggtgc tccaggtcca gaaggtgaac caggtgaagc tggtccagaa 540
ggtgctccag gtccagctgg tgaaccaggt gctccaggtc caccaggtga accaggtcca 600
gctggtgaag ctggtgaacc aggtgctcca ggtccagctg gtgaagctgg tccaccaggt 660
gctccaggtc cagctggtcc accaggtcca gctggtgctc caggtgaacc aggtccagct 720
ggtccaccag gtgctgaagg tgctccaggt ccagctggtc cagaaggtga agctggtgct 780
gaaggtgaac caggtgaagc tggtccacca ggtgctccag gtgaagctgg tgctgaaggt 840
gctccaggtc cagaaggtga accaggtgaa gctggtccag aaggtgctcc aggtccagct 900
ggtgaaccag gtgctccagg tccaccaggt gaaccaggtc cagctggtga agctggtgaa 960
ccaggtgctc caggtccagc tggtgaagct ggtccaccag gtgctccagg tccagctggt 1020
ccaccaggtc cagctggtgc tccaggtgaa ccaggtccag ctggtccacc aggtgctgaa 1080
ggtgctccag gtccagctgg tccagaaggt gaagctggtg ctgaaggtga accaggtgaa 1140
gctggtccac caggtgctcc aggtgaagct ggtgctgaag gtgctccagg tccagaaggt 1200
gaaccaggtg aagctggtcc agaaggtgct ccaggtccag ctggtgaacc aggtgctcca 1260
ggtccaccag gtgaaccagg tccagctggt gaagctggtg aaccaggtgc tccaggtcca 1320
gctggtgaag ctggtccacc aggtgctcca ggtccagctg gtccaccagg tccagctggt 1380
gctccaggtg aaccaggtcc agctggtcca ccaggtgctg aaggtgctcc aggtccagct 1440
ggtccagaag gtgaagctgg tgctgaaggt gaaccaggtg aagctggtcc accaggtgct 1500
ccaggtgaag ctggtgctga aggtgctcca ggtccagaag gtgaaccagg tgaagctggt 1560
ccagaaggtg ctccaggtcc agctggtgaa ccaggtgctc caggtccacc aggtgaacca 1620
ggtccagctg gtgaagctgg tgaaccaggt gctccaggtc cagctggtga agctggtcca 1680
ccaggtgctc caggtccagc tggtccacca ggtccagctg gtgctccagg tgaaccaggt 1740
ccagctggtc caccaggtgc tgaaggtgct ccaggtccag ctggtccaga aggtgaagct 1800
ggtgctgaag gtgaaccagg tgaagctggt ccaccaggtg ctccaggtga agctggtgct 1860
gaaggtgctc caggtccaga aggtgaacca ggtgaagctg gtccagaagg tgctccaggt 1920
ccagctggtg aaccaggtgc tccaggtcca ccaggtgaac caggtccagc tggtgaagct 1980
ggtgaaccag gtgctccagg tccagctggt gaagctggtc caccaggtgc tccaggtcca 2040
gctggtccac caggtccagc tggtgctcca ggtgaaccag gtccagctgg tccaccaggt 2100
gctgaaggtg ctccaggtcc agctggtcca gaaggtgaag ctggtgctga aggtgaacca 2160
ggtgaagctg gtccaccagg tgctccaggt gaagctggtg ctgaaggtgc tccaggtcca 2220
gaaggtgaac caggtgaagc tggtccagaa ggtgctccag gtccagctgg tgaaccaggt 2280
gctccaggtc caccaggtga accaggtcca gctggtgaag ctggtgaacc aggtgctcca 2340
ggtccagctg gtgaagctgg tccaccaggt gctccaggtc cagctggtcc accaggtcca 2400
gctggtgctc caggtgaacc aggtccagct ggtccaccag gtgctgaagg tgctccaggt 2460
ccagctggtc cagaaggtga agctggtgct gaaggtgaac caggtgaagc tggtccacca 2520
ggtgctccag gtgaagctgg tgctgaaggt gctccaggtc cagaaggtga accaggtgaa 2580
gctggtccag aaggtgctcc aggtccagct ggtgaaccag gtgctccagg tccaccaggt 2640
gaaccaggtc cagctggtga agctggtgaa ccaggtgctc caggtccagc tggtgaagct 2700
ggtccaccag gtgctccagg tccagctggt ccaccaggtc cagctggtgg attcccaact 2760
attccattgt ctagattgtt cgacaacgct atgttgagag cccacagatt gcaccaattg 2820
gctttcgaca cttaccaaga attcgaagaa gcttacattc caaaggaaca gaagtactct 2880
ttcttgcaaa acccacaaac ttctttgtgt ttctctgaat ctattccaac tccatctaac 2940
agagaagaaa ctcaacaaaa gtctaacttg gaattgttga gaatttcttt gttgttgatt 3000
caatcttggt tggaaccagt tcaattcttg agatctgttt tcgctaactc tttggtttac 3060
ggtgcttctg actctaacgt ttacgacttg ttgaaggact tggaagaagg tattcaaact 3120
ttgatgggta gattggaaga cggttctcct agaactggtc aaattttcaa gcaaacttac 3180
tctaagttcg acactaactc tcacaacgac gacgctttgt tgaagaacta cggtttgttg 3240
tactgtttca gaaaggacat ggacaaggtt gaaactttct tgagaattgt tcaatgtaga 3300
tctgttgaag gttcttgtgg tttcggtcca cctggtgctc caggtgaacc aggtccagct 3360
ggtccaccag gtgctgaagg tgctccaggt ccagctggtc cagaaggtga agctggtgct 3420
gaaggtgaac caggtgaagc tggtccacca ggtgctccag gtgaagctgg tgctgaaggt 3480
gctccaggtc cagaaggtga accaggtgaa gctggtccag aaggtgctcc aggtccagct 3540
ggtgaaccag gtgctccagg tccaccaggt gaaccaggtc cagctggtga agctggtgaa 3600
ccaggtgctc caggtccagc tggtgaagct ggtccaccag gtgctccagg tccagctggt 3660
ccaccaggtc cagct 3675
<210> 277
<211> 345
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 277
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
130 135 140
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
165 170 175
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
180 185 190
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
210 215 220
Pro Gly Glu Pro Gly Pro Ala Gly Gly Ala Arg Asn Gly Asp His Cys
225 230 235 240
Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser
245 250 255
Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val
260 265 270
Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala
275 280 285
Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp
290 295 300
Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val
305 310 315 320
Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp
325 330 335
Leu Leu Ala Lys Asp Cys His Cys Ile
340 345
<210> 278
<211> 1035
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 278
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc tggtgaagct 360
ggtgcacccg gacccgaagg tgccgaagga gaggctggtg aacctggacc cgccggtgaa 420
ccaggacctg aaggagctcc aggtcctcct ggacccgcag gagagcccgg tcctgccggt 480
gctcctggtc cacccggaga agcaggtcca gccggagctc ctggtgaggc tggtccccca 540
ggacccgctg gagctgaagg tgaggcaggt ccagccggcg ctccaggtga gccaggacca 600
gaaggtccac caggagaagc tggagcaccc ggtcctccag gagcacccgg cgctgaagga 660
gaacccggtg ctcctggaga acccggtcca gctggtggag ctagaaacgg tgatcattgt 720
ccattgggtc caggtagatg ttgtagattg catactgtta gagcttcttt ggaagatttg 780
ggttgggctg attgggtttt gtctccaaga gaagttcaag ttactatgtg tattggtgct 840
tgtccatctc aatttagagc tgctaacatg catgctcaaa ttaagacttc tttgcataga 900
ttgaagccag atactgttcc agctccatgt tgtgttccag cttcttacaa cccaatggtt 960
ttgattcaaa agactgatac tggtgtttct ttgcaaactt acgatgattt gttggctaag 1020
gattgtcatt gtatt 1035
<210> 279
<211> 329
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 279
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly
1 5 10 15
Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu
20 25 30
Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu
35 40 45
Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly
50 55 60
Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu
65 70 75 80
Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro
115 120 125
Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala
130 135 140
Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly
145 150 155 160
Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro
165 170 175
Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro
180 185 190
Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly
195 200 205
Pro Pro Gly Ala Pro Gly Pro Ala Gly Ala Arg Asn Gly Asp His Cys
210 215 220
Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser
225 230 235 240
Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val
245 250 255
Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala
260 265 270
Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp
275 280 285
Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val
290 295 300
Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp
305 310 315 320
Leu Leu Ala Lys Asp Cys His Cys Ile
325
<210> 280
<211> 987
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 280
ggtgctccag gtgaaccagg tccagctggt ccaccaggtg ctgaaggtgc tccaggtcca 60
gctggtccag aaggtgaagc tggtgctgaa ggtgaaccag gtgaagctgg tccaccaggt 120
gctccaggtg aagctggtgc tgaaggtgct ccaggtccag aaggtgaacc aggtgaagct 180
ggtccagaag gtgctccagg tccagctggt gaaccaggtg ctccaggtga agctggtgaa 240
ccaggtccac caggtccagc tggtgctcca ggtccagctg gtgaaccagg tgaagctggt 300
ccaccaggtg ctccaggtcc agctggtgct ccaggtgaac caggtccagc tggtccacca 360
ggtgctgaag gtgctccagg tccagctggt ccagaaggtg aagctggtgc tgaaggtgaa 420
ccaggtgaag ctggtccacc aggtgctcca ggtgaagctg gtgctgaagg tgctccaggt 480
ccagaaggtg aaccaggtga agctggtcca gaaggtgctc caggtccagc tggtgaacca 540
ggtgctccag gtgaagctgg tgaaccaggt ccaccaggtc cagctggtgc tccaggtcca 600
gctggtgaac caggtgaagc tggtccacca ggtgctccag gtccagctgg tgctagaaac 660
ggtgatcatt gtccattggg tccaggtaga tgttgtagat tgcatactgt tagagcttct 720
ttggaagatt tgggttgggc tgattgggtt ttgtctccaa gagaagttca agttactatg 780
tgtattggtg cttgtccatc tcaatttaga gctgctaaca tgcatgctca aattaagact 840
tctttgcata gattgaagcc agatactgtt ccagctccat gttgtgttcc agcttcttac 900
aacccaatgg ttttgattca aaagactgat actggtgttt ctttgcaaac ttacgatgat 960
ttgttggcta aggattgtca ttgtatt 987
<210> 281
<211> 329
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 281
Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Glu Ala Gly Ala Pro Gly
1 5 10 15
Pro Glu Gly Ala Ala Gly Glu Pro Gly Pro Glu Gly Glu Glu Gly Glu
20 25 30
Ala Gly Ala Pro Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Pro Ala
35 40 45
Gly Pro Pro Gly Ala Ala Gly Pro Ala Gly Ala Glu Gly Glu Glu Gly
50 55 60
Glu Pro Gly Glu Pro Gly Pro Ala Gly Ala Glu Gly Pro Pro Gly Ala
65 70 75 80
Ala Gly Pro Ala Gly Pro Glu Gly Pro Glu Gly Ala Ala Gly Ala Glu
85 90 95
Gly Glu Glu Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Glu Ala Gly
100 105 110
Pro Pro Gly Glu Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Ala Gly Glu Pro Gly Pro Glu Gly Glu Glu Gly Glu Ala Gly Ala Pro
130 135 140
Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly
145 150 155 160
Ala Ala Gly Pro Ala Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Glu
165 170 175
Pro Gly Pro Ala Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly Pro Ala
180 185 190
Gly Pro Glu Gly Pro Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly
195 200 205
Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Arg Asn Gly Asp His Cys
210 215 220
Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser
225 230 235 240
Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val
245 250 255
Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala
260 265 270
Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp
275 280 285
Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val
290 295 300
Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp
305 310 315 320
Leu Leu Ala Lys Asp Cys His Cys Ile
325
<210> 282
<211> 987
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 282
ggtgaagctg gtccaccagg tgaagctggt gaagctggtg ctccaggtcc agaaggtgct 60
gctggtgaac caggtccaga aggtgaagaa ggtgaagctg gtgctccagg tgaagaaggt 120
ccaccaggtg aagctggtcc agctggtcca ccaggtgctg ctggtccagc tggtgctgaa 180
ggtgaagaag gtgaaccagg tgaaccaggt ccagctggtg ctgaaggtcc accaggtgct 240
gctggtccag ctggtccaga aggtccagaa ggtgctgctg gtgctgaagg tgaagaaggt 300
gaagctggtc caccaggtcc agctggtgaa gctggtccac caggtgaagc tggtgaagct 360
ggtgctccag gtccagaagg tgctgctggt gaaccaggtc cagaaggtga agaaggtgaa 420
gctggtgctc caggtgaaga aggtccacca ggtgaagctg gtccagctgg tccaccaggt 480
gctgctggtc cagctggtgc tgaaggtgaa gaaggtgaac caggtgaacc aggtccagct 540
ggtgctgaag gtccaccagg tgctgctggt ccagctggtc cagaaggtcc agaaggtgct 600
gctggtgctg aaggtgaaga aggtgaagct ggtccaccag gtccagctgg tgctagaaac 660
ggtgatcatt gtccattggg tccaggtaga tgttgtagat tgcatactgt tagagcttct 720
ttggaagatt tgggttgggc tgattgggtt ttgtctccaa gagaagttca agttactatg 780
tgtattggtg cttgtccatc tcaatttaga gctgctaaca tgcatgctca aattaagact 840
tctttgcata gattgaagcc agatactgtt ccagctccat gttgtgttcc agcttcttac 900
aacccaatgg ttttgattca aaagactgat actggtgttt ctttgcaaac ttacgatgat 960
ttgttggcta aggattgtca ttgtatt 987
<210> 283
<211> 345
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 283
Gly Pro Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly
1 5 10 15
Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala
20 25 30
Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala
35 40 45
Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly
50 55 60
Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu
65 70 75 80
Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala
85 90 95
Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly
100 105 110
Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro
115 120 125
Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala
130 135 140
Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly
145 150 155 160
Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu
165 170 175
Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro
180 185 190
Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly
195 200 205
Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro
210 215 220
Ala Gly Pro Pro Gly Pro Ala Gly Gly Ala Arg Asn Gly Asp His Cys
225 230 235 240
Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser
245 250 255
Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val
260 265 270
Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala
275 280 285
Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp
290 295 300
Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val
305 310 315 320
Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp
325 330 335
Leu Leu Ala Lys Asp Cys His Cys Ile
340 345
<210> 284
<211> 1035
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 284
ggtccacctg gtgctccagg tgaaccaggt ccagctggtc caccaggtgc tgaaggtgct 60
ccaggtccag ctggtccaga aggtgaagct ggtgctgaag gtgaaccagg tgaagctggt 120
ccaccaggtg ctccaggtga agctggtgct gaaggtgctc caggtccaga aggtgaacca 180
ggtgaagctg gtccagaagg tgctccaggt ccagctggtg aaccaggtgc tccaggtgaa 240
gctggtgaac caggtccacc aggtccagct ggtgctccag gtccagctgg tgaaccaggt 300
gaagctggtc caccaggtgc tccaggtcca gctggtccac caggtccagc tggtgctcca 360
ggtgaaccag gtccagctgg tccaccaggt gctgaaggtg ctccaggtcc agctggtcca 420
gaaggtgaag ctggtgctga aggtgaacca ggtgaagctg gtccaccagg tgctccaggt 480
gaagctggtg ctgaaggtgc tccaggtcca gaaggtgaac caggtgaagc tggtccagaa 540
ggtgctccag gtccagctgg tgaaccaggt gctccaggtg aagctggtga accaggtcca 600
ccaggtccag ctggtgctcc aggtccagct ggtgaaccag gtgaagctgg tccaccaggt 660
gctccaggtc cagctggtcc accaggtcca gctggtggag ctagaaacgg tgatcattgt 720
ccattgggtc caggtagatg ttgtagattg catactgtta gagcttcttt ggaagatttg 780
ggttgggctg attgggtttt gtctccaaga gaagttcaag ttactatgtg tattggtgct 840
tgtccatctc aatttagagc tgctaacatg catgctcaaa ttaagacttc tttgcataga 900
ttgaagccag atactgttcc agctccatgt tgtgttccag cttcttacaa cccaatggtt 960
ttgattcaaa agactgatac tggtgtttct ttgcaaactt acgatgattt gttggctaag 1020
gattgtcatt gtatt 1035
<210> 285
<211> 573
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 285
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
130 135 140
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
165 170 175
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
180 185 190
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
210 215 220
Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu
225 230 235 240
Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly
245 250 255
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
260 265 270
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro
275 280 285
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
290 295 300
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu
305 310 315 320
Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro
325 330 335
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly
340 345 350
Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu
355 360 365
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
370 375 380
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly
385 390 395 400
Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu
405 410 415
Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro
420 425 430
Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly
435 440 445
Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Gly Ala Arg Asn
450 455 460
Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr
465 470 475 480
Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser
485 490 495
Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln
500 505 510
Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg
515 520 525
Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr
530 535 540
Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln
545 550 555 560
Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile
565 570
<210> 286
<211> 1719
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 286
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc tggtgaagct 360
ggtgcacccg gacccgaagg tgccgaagga gaggctggtg aacctggacc cgccggtgaa 420
ccaggacctg aaggagctcc aggtcctcct ggacccgcag gagagcccgg tcctgccggt 480
gctcctggtc cacccggaga agcaggtcca gccggagctc ctggtgaggc tggtccccca 540
ggacccgctg gagctgaagg tgaggcaggt ccagccggcg ctccaggtga gccaggacca 600
gaaggtccac caggagaagc tggagcaccc ggtcctccag gagcacccgg cgctgaagga 660
gaacccggtg ctcctggaga acccggtcca gctggtgaag ctggtgcacc cggacccgaa 720
ggtgccgaag gagaggctgg tgaacctgga cccgccggtg aaccaggacc tgaaggagct 780
ccaggtcctc ctggacccgc aggagagccc ggtcctgccg gtgctcctgg tccacccgga 840
gaagcaggtc cagccggagc tcctggtgag gctggtcccc caggacccgc tggagctgaa 900
ggtgaggcag gtccagccgg cgctccaggt gagccaggac cagaaggtcc accaggagaa 960
gctggagcac ccggtcctcc aggagcaccc ggcgctgaag gagaacccgg tgctcctgga 1020
gaacccggtc cagctggtga agctggtgca cccggacccg aaggtgccga aggagaggct 1080
ggtgaacctg gacccgccgg tgaaccagga cctgaaggag ctccaggtcc tcctggaccc 1140
gcaggagagc ccggtcctgc cggtgctcct ggtccacccg gagaagcagg tccagccgga 1200
gctcctggtg aggctggtcc cccaggaccc gctggagctg aaggtgaggc aggtccagcc 1260
ggcgctccag gtgagccagg accagaaggt ccaccaggag aagctggagc acccggtcct 1320
ccaggagcac ccggcgctga aggagaaccc ggtgctcctg gagaacccgg tccagctggt 1380
ggagctagaa acggtgatca ttgtccattg ggtccaggta gatgttgtag attgcatact 1440
gttagagctt ctttggaaga tttgggttgg gctgattggg ttttgtctcc aagagaagtt 1500
caagttacta tgtgtattgg tgcttgtcca tctcaattta gagctgctaa catgcatgct 1560
caaattaaga cttctttgca tagattgaag ccagatactg ttccagctcc atgttgtgtt 1620
ccagcttctt acaacccaat ggttttgatt caaaagactg atactggtgt ttctttgcaa 1680
acttacgatg atttgttggc taaggattgt cattgtatt 1719
<210> 287
<211> 545
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 287
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly
1 5 10 15
Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu
20 25 30
Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu
35 40 45
Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly
50 55 60
Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu
65 70 75 80
Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro
115 120 125
Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala
130 135 140
Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly
145 150 155 160
Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro
165 170 175
Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro
180 185 190
Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly
195 200 205
Pro Pro Gly Ala Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
210 215 220
Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu
225 230 235 240
Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly
245 250 255
Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu
260 265 270
Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro
275 280 285
Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly
290 295 300
Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala
305 310 315 320
Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro
325 330 335
Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly
340 345 350
Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu
355 360 365
Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala
370 375 380
Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly
385 390 395 400
Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro
405 410 415
Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala
420 425 430
Gly Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys
435 440 445
Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp
450 455 460
Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala
465 470 475 480
Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr
485 490 495
Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val
500 505 510
Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly
515 520 525
Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys
530 535 540
Ile
545
<210> 288
<211> 1635
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 288
ggtgctccag gtgaaccagg tccagctggt ccaccaggtg ctgaaggtgc tccaggtcca 60
gctggtccag aaggtgaagc tggtgctgaa ggtgaaccag gtgaagctgg tccaccaggt 120
gctccaggtg aagctggtgc tgaaggtgct ccaggtccag aaggtgaacc aggtgaagct 180
ggtccagaag gtgctccagg tccagctggt gaaccaggtg ctccaggtga agctggtgaa 240
ccaggtccac caggtccagc tggtgctcca ggtccagctg gtgaaccagg tgaagctggt 300
ccaccaggtg ctccaggtcc agctggtgct ccaggtgaac caggtccagc tggtccacca 360
ggtgctgaag gtgctccagg tccagctggt ccagaaggtg aagctggtgc tgaaggtgaa 420
ccaggtgaag ctggtccacc aggtgctcca ggtgaagctg gtgctgaagg tgctccaggt 480
ccagaaggtg aaccaggtga agctggtcca gaaggtgctc caggtccagc tggtgaacca 540
ggtgctccag gtgaagctgg tgaaccaggt ccaccaggtc cagctggtgc tccaggtcca 600
gctggtgaac caggtgaagc tggtccacca ggtgctccag gtccagctgg tgctccaggt 660
gaaccaggtc cagctggtcc accaggtgct gaaggtgctc caggtccagc tggtccagaa 720
ggtgaagctg gtgctgaagg tgaaccaggt gaagctggtc caccaggtgc tccaggtgaa 780
gctggtgctg aaggtgctcc aggtccagaa ggtgaaccag gtgaagctgg tccagaaggt 840
gctccaggtc cagctggtga accaggtgct ccaggtgaag ctggtgaacc aggtccacca 900
ggtccagctg gtgctccagg tccagctggt gaaccaggtg aagctggtcc accaggtgct 960
ccaggtccag ctggtgctcc aggtgaacca ggtccagctg gtccaccagg tgctgaaggt 1020
gctccaggtc cagctggtcc agaaggtgaa gctggtgctg aaggtgaacc aggtgaagct 1080
ggtccaccag gtgctccagg tgaagctggt gctgaaggtg ctccaggtcc agaaggtgaa 1140
ccaggtgaag ctggtccaga aggtgctcca ggtccagctg gtgaaccagg tgctccaggt 1200
gaagctggtg aaccaggtcc accaggtcca gctggtgctc caggtccagc tggtgaacca 1260
ggtgaagctg gtccaccagg tgctccaggt ccagctggtg ctagaaacgg tgatcattgt 1320
ccattgggtc caggtagatg ttgtagattg catactgtta gagcttcttt ggaagatttg 1380
ggttgggctg attgggtttt gtctccaaga gaagttcaag ttactatgtg tattggtgct 1440
tgtccatctc aatttagagc tgctaacatg catgctcaaa ttaagacttc tttgcataga 1500
ttgaagccag atactgttcc agctccatgt tgtgttccag cttcttacaa cccaatggtt 1560
ttgattcaaa agactgatac tggtgtttct ttgcaaactt acgatgattt gttggctaag 1620
gattgtcatt gtatt 1635
<210> 289
<211> 545
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 289
Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Glu Ala Gly Ala Pro Gly
1 5 10 15
Pro Glu Gly Ala Ala Gly Glu Pro Gly Pro Glu Gly Glu Glu Gly Glu
20 25 30
Ala Gly Ala Pro Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Pro Ala
35 40 45
Gly Pro Pro Gly Ala Ala Gly Pro Ala Gly Ala Glu Gly Glu Glu Gly
50 55 60
Glu Pro Gly Glu Pro Gly Pro Ala Gly Ala Glu Gly Pro Pro Gly Ala
65 70 75 80
Ala Gly Pro Ala Gly Pro Glu Gly Pro Glu Gly Ala Ala Gly Ala Glu
85 90 95
Gly Glu Glu Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Glu Ala Gly
100 105 110
Pro Pro Gly Glu Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Ala Gly Glu Pro Gly Pro Glu Gly Glu Glu Gly Glu Ala Gly Ala Pro
130 135 140
Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly
145 150 155 160
Ala Ala Gly Pro Ala Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Glu
165 170 175
Pro Gly Pro Ala Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly Pro Ala
180 185 190
Gly Pro Glu Gly Pro Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly
195 200 205
Glu Ala Gly Pro Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Glu
210 215 220
Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Ala Gly Glu Pro
225 230 235 240
Gly Pro Glu Gly Glu Glu Gly Glu Ala Gly Ala Pro Gly Glu Glu Gly
245 250 255
Pro Pro Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly Ala Ala Gly Pro
260 265 270
Ala Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Glu Pro Gly Pro Ala
275 280 285
Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly Pro Ala Gly Pro Glu Gly
290 295 300
Pro Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly Glu Ala Gly Pro
305 310 315 320
Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Glu Ala
325 330 335
Gly Ala Pro Gly Pro Glu Gly Ala Ala Gly Glu Pro Gly Pro Glu Gly
340 345 350
Glu Glu Gly Glu Ala Gly Ala Pro Gly Glu Glu Gly Pro Pro Gly Glu
355 360 365
Ala Gly Pro Ala Gly Pro Pro Gly Ala Ala Gly Pro Ala Gly Ala Glu
370 375 380
Gly Glu Glu Gly Glu Pro Gly Glu Pro Gly Pro Ala Gly Ala Glu Gly
385 390 395 400
Pro Pro Gly Ala Ala Gly Pro Ala Gly Pro Glu Gly Pro Glu Gly Ala
405 410 415
Ala Gly Ala Glu Gly Glu Glu Gly Glu Ala Gly Pro Pro Gly Pro Ala
420 425 430
Gly Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys
435 440 445
Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp
450 455 460
Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala
465 470 475 480
Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr
485 490 495
Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val
500 505 510
Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly
515 520 525
Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys
530 535 540
Ile
545
<210> 290
<211> 1635
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 290
ggtgaagctg gtccaccagg tgaagctggt gaagctggtg ctccaggtcc agaaggtgct 60
gctggtgaac caggtccaga aggtgaagaa ggtgaagctg gtgctccagg tgaagaaggt 120
ccaccaggtg aagctggtcc agctggtcca ccaggtgctg ctggtccagc tggtgctgaa 180
ggtgaagaag gtgaaccagg tgaaccaggt ccagctggtg ctgaaggtcc accaggtgct 240
gctggtccag ctggtccaga aggtccagaa ggtgctgctg gtgctgaagg tgaagaaggt 300
gaagctggtc caccaggtcc agctggtgaa gctggtccac caggtgaagc tggtgaagct 360
ggtgctccag gtccagaagg tgctgctggt gaaccaggtc cagaaggtga agaaggtgaa 420
gctggtgctc caggtgaaga aggtccacca ggtgaagctg gtccagctgg tccaccaggt 480
gctgctggtc cagctggtgc tgaaggtgaa gaaggtgaac caggtgaacc aggtccagct 540
ggtgctgaag gtccaccagg tgctgctggt ccagctggtc cagaaggtcc agaaggtgct 600
gctggtgctg aaggtgaaga aggtgaagct ggtccaccag gtccagctgg tgaagctggt 660
ccaccaggtg aagctggtga agctggtgct ccaggtccag aaggtgctgc tggtgaacca 720
ggtccagaag gtgaagaagg tgaagctggt gctccaggtg aagaaggtcc accaggtgaa 780
gctggtccag ctggtccacc aggtgctgct ggtccagctg gtgctgaagg tgaagaaggt 840
gaaccaggtg aaccaggtcc agctggtgct gaaggtccac caggtgctgc tggtccagct 900
ggtccagaag gtccagaagg tgctgctggt gctgaaggtg aagaaggtga agctggtcca 960
ccaggtccag ctggtgaagc tggtccacca ggtgaagctg gtgaagctgg tgctccaggt 1020
ccagaaggtg ctgctggtga accaggtcca gaaggtgaag aaggtgaagc tggtgctcca 1080
ggtgaagaag gtccaccagg tgaagctggt ccagctggtc caccaggtgc tgctggtcca 1140
gctggtgctg aaggtgaaga aggtgaacca ggtgaaccag gtccagctgg tgctgaaggt 1200
ccaccaggtg ctgctggtcc agctggtcca gaaggtccag aaggtgctgc tggtgctgaa 1260
ggtgaagaag gtgaagctgg tccaccaggt ccagctggtg ctagaaacgg tgatcattgt 1320
ccattgggtc caggtagatg ttgtagattg catactgtta gagcttcttt ggaagatttg 1380
ggttgggctg attgggtttt gtctccaaga gaagttcaag ttactatgtg tattggtgct 1440
tgtccatctc aatttagagc tgctaacatg catgctcaaa ttaagacttc tttgcataga 1500
ttgaagccag atactgttcc agctccatgt tgtgttccag cttcttacaa cccaatggtt 1560
ttgattcaaa agactgatac tggtgtttct ttgcaaactt acgatgattt gttggctaag 1620
gattgtcatt gtatt 1635
<210> 291
<211> 573
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 291
Gly Pro Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly
1 5 10 15
Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala
20 25 30
Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala
35 40 45
Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly
50 55 60
Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu
65 70 75 80
Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala
85 90 95
Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly
100 105 110
Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro
115 120 125
Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala
130 135 140
Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly
145 150 155 160
Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu
165 170 175
Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro
180 185 190
Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly
195 200 205
Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro
210 215 220
Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala
225 230 235 240
Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly
245 250 255
Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala
260 265 270
Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro
275 280 285
Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly
290 295 300
Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala
305 310 315 320
Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro
325 330 335
Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly
340 345 350
Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro
355 360 365
Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro
370 375 380
Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly
385 390 395 400
Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu
405 410 415
Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala
420 425 430
Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly
435 440 445
Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Gly Ala Arg Asn
450 455 460
Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr
465 470 475 480
Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser
485 490 495
Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln
500 505 510
Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg
515 520 525
Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr
530 535 540
Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln
545 550 555 560
Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile
565 570
<210> 292
<211> 1719
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 292
ggtccacctg gtgctccagg tgaaccaggt ccagctggtc caccaggtgc tgaaggtgct 60
ccaggtccag ctggtccaga aggtgaagct ggtgctgaag gtgaaccagg tgaagctggt 120
ccaccaggtg ctccaggtga agctggtgct gaaggtgctc caggtccaga aggtgaacca 180
ggtgaagctg gtccagaagg tgctccaggt ccagctggtg aaccaggtgc tccaggtgaa 240
gctggtgaac caggtccacc aggtccagct ggtgctccag gtccagctgg tgaaccaggt 300
gaagctggtc caccaggtgc tccaggtcca gctggtccac caggtccagc tggtgctcca 360
ggtgaaccag gtccagctgg tccaccaggt gctgaaggtg ctccaggtcc agctggtcca 420
gaaggtgaag ctggtgctga aggtgaacca ggtgaagctg gtccaccagg tgctccaggt 480
gaagctggtg ctgaaggtgc tccaggtcca gaaggtgaac caggtgaagc tggtccagaa 540
ggtgctccag gtccagctgg tgaaccaggt gctccaggtg aagctggtga accaggtcca 600
ccaggtccag ctggtgctcc aggtccagct ggtgaaccag gtgaagctgg tccaccaggt 660
gctccaggtc cagctggtcc accaggtcca gctggtgctc caggtgaacc aggtccagct 720
ggtccaccag gtgctgaagg tgctccaggt ccagctggtc cagaaggtga agctggtgct 780
gaaggtgaac caggtgaagc tggtccacca ggtgctccag gtgaagctgg tgctgaaggt 840
gctccaggtc cagaaggtga accaggtgaa gctggtccag aaggtgctcc aggtccagct 900
ggtgaaccag gtgctccagg tgaagctggt gaaccaggtc caccaggtcc agctggtgct 960
ccaggtccag ctggtgaacc aggtgaagct ggtccaccag gtgctccagg tccagctggt 1020
ccaccaggtc cagctggtgc tccaggtgaa ccaggtccag ctggtccacc aggtgctgaa 1080
ggtgctccag gtccagctgg tccagaaggt gaagctggtg ctgaaggtga accaggtgaa 1140
gctggtccac caggtgctcc aggtgaagct ggtgctgaag gtgctccagg tccagaaggt 1200
gaaccaggtg aagctggtcc agaaggtgct ccaggtccag ctggtgaacc aggtgctcca 1260
ggtgaagctg gtgaaccagg tccaccaggt ccagctggtg ctccaggtcc agctggtgaa 1320
ccaggtgaag ctggtccacc aggtgctcca ggtccagctg gtccaccagg tccagctggt 1380
ggagctagaa acggtgatca ttgtccattg ggtccaggta gatgttgtag attgcatact 1440
gttagagctt ctttggaaga tttgggttgg gctgattggg ttttgtctcc aagagaagtt 1500
caagttacta tgtgtattgg tgcttgtcca tctcaattta gagctgctaa catgcatgct 1560
caaattaaga cttctttgca tagattgaag ccagatactg ttccagctcc atgttgtgtt 1620
ccagcttctt acaacccaat ggttttgatt caaaagactg atactggtgt ttctttgcaa 1680
acttacgatg atttgttggc taaggattgt cattgtatt 1719
<210> 293
<211> 801
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 293
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
130 135 140
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
165 170 175
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
180 185 190
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
210 215 220
Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu
225 230 235 240
Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly
245 250 255
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
260 265 270
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro
275 280 285
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
290 295 300
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu
305 310 315 320
Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro
325 330 335
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly
340 345 350
Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu
355 360 365
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
370 375 380
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly
385 390 395 400
Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu
405 410 415
Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro
420 425 430
Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly
435 440 445
Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala
450 455 460
Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala
465 470 475 480
Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly
485 490 495
Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro
500 505 510
Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu
515 520 525
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly
530 535 540
Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala
545 550 555 560
Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala
565 570 575
Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly
580 585 590
Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
595 600 605
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
610 615 620
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
625 630 635 640
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
645 650 655
Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
660 665 670
Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly
675 680 685
Gly Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys
690 695 700
Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp
705 710 715 720
Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala
725 730 735
Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr
740 745 750
Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val
755 760 765
Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly
770 775 780
Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys
785 790 795 800
Ile
<210> 294
<211> 2403
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 294
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc tggtgaagct 360
ggtgcacccg gacccgaagg tgccgaagga gaggctggtg aacctggacc cgccggtgaa 420
ccaggacctg aaggagctcc aggtcctcct ggacccgcag gagagcccgg tcctgccggt 480
gctcctggtc cacccggaga agcaggtcca gccggagctc ctggtgaggc tggtccccca 540
ggacccgctg gagctgaagg tgaggcaggt ccagccggcg ctccaggtga gccaggacca 600
gaaggtccac caggagaagc tggagcaccc ggtcctccag gagcacccgg cgctgaagga 660
gaacccggtg ctcctggaga acccggtcca gctggtgaag ctggtgcacc cggacccgaa 720
ggtgccgaag gagaggctgg tgaacctgga cccgccggtg aaccaggacc tgaaggagct 780
ccaggtcctc ctggacccgc aggagagccc ggtcctgccg gtgctcctgg tccacccgga 840
gaagcaggtc cagccggagc tcctggtgag gctggtcccc caggacccgc tggagctgaa 900
ggtgaggcag gtccagccgg cgctccaggt gagccaggac cagaaggtcc accaggagaa 960
gctggagcac ccggtcctcc aggagcaccc ggcgctgaag gagaacccgg tgctcctgga 1020
gaacccggtc cagctggtga agctggtgca cccggacccg aaggtgccga aggagaggct 1080
ggtgaacctg gacccgccgg tgaaccagga cctgaaggag ctccaggtcc tcctggaccc 1140
gcaggagagc ccggtcctgc cggtgctcct ggtccacccg gagaagcagg tccagccgga 1200
gctcctggtg aggctggtcc cccaggaccc gctggagctg aaggtgaggc aggtccagcc 1260
ggcgctccag gtgagccagg accagaaggt ccaccaggag aagctggagc acccggtcct 1320
ccaggagcac ccggcgctga aggagaaccc ggtgctcctg gagaacccgg tccagctggt 1380
gaagctggtg cacccggacc cgaaggtgcc gaaggagagg ctggtgaacc tggacccgcc 1440
ggtgaaccag gacctgaagg agctccaggt cctcctggac ccgcaggaga gcccggtcct 1500
gccggtgctc ctggtccacc cggagaagca ggtccagccg gagctcctgg tgaggctggt 1560
cccccaggac ccgctggagc tgaaggtgag gcaggtccag ccggcgctcc aggtgagcca 1620
ggaccagaag gtccaccagg agaagctgga gcacccggtc ctccaggagc acccggcgct 1680
gaaggagaac ccggtgctcc tggagaaccc ggtccagctg gtgaagctgg tgcacccgga 1740
cccgaaggtg ccgaaggaga ggctggtgaa cctggacccg ccggtgaacc aggacctgaa 1800
ggagctccag gtcctcctgg acccgcagga gagcccggtc ctgccggtgc tcctggtcca 1860
cccggagaag caggtccagc cggagctcct ggtgaggctg gtcccccagg acccgctgga 1920
gctgaaggtg aggcaggtcc agccggcgct ccaggtgagc caggaccaga aggtccacca 1980
ggagaagctg gagcacccgg tcctccagga gcacccggcg ctgaaggaga acccggtgct 2040
cctggagaac ccggtccagc tggtggagct agaaacggtg atcattgtcc attgggtcca 2100
ggtagatgtt gtagattgca tactgttaga gcttctttgg aagatttggg ttgggctgat 2160
tgggttttgt ctccaagaga agttcaagtt actatgtgta ttggtgcttg tccatctcaa 2220
tttagagctg ctaacatgca tgctcaaatt aagacttctt tgcatagatt gaagccagat 2280
actgttccag ctccatgttg tgttccagct tcttacaacc caatggtttt gattcaaaag 2340
actgatactg gtgtttcttt gcaaacttac gatgatttgt tggctaagga ttgtcattgt 2400
att 2403
<210> 295
<211> 761
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 295
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly
1 5 10 15
Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu
20 25 30
Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu
35 40 45
Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly
50 55 60
Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu
65 70 75 80
Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro
85 90 95
Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro
115 120 125
Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala
130 135 140
Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly
145 150 155 160
Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro
165 170 175
Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro
180 185 190
Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly
195 200 205
Pro Pro Gly Ala Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
210 215 220
Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu
225 230 235 240
Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly
245 250 255
Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu
260 265 270
Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro
275 280 285
Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly
290 295 300
Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala
305 310 315 320
Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro
325 330 335
Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly
340 345 350
Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu
355 360 365
Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala
370 375 380
Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly
385 390 395 400
Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro
405 410 415
Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala
420 425 430
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly
435 440 445
Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu
450 455 460
Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu
465 470 475 480
Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly
485 490 495
Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu
500 505 510
Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro
515 520 525
Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Ala Pro Gly
530 535 540
Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro
545 550 555 560
Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala
565 570 575
Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly
580 585 590
Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro
595 600 605
Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro
610 615 620
Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly
625 630 635 640
Pro Pro Gly Ala Pro Gly Pro Ala Gly Ala Arg Asn Gly Asp His Cys
645 650 655
Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser
660 665 670
Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val
675 680 685
Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala
690 695 700
Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp
705 710 715 720
Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val
725 730 735
Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp
740 745 750
Leu Leu Ala Lys Asp Cys His Cys Ile
755 760
<210> 296
<211> 2283
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 296
ggtgctccag gtgaaccagg tccagctggt ccaccaggtg ctgaaggtgc tccaggtcca 60
gctggtccag aaggtgaagc tggtgctgaa ggtgaaccag gtgaagctgg tccaccaggt 120
gctccaggtg aagctggtgc tgaaggtgct ccaggtccag aaggtgaacc aggtgaagct 180
ggtccagaag gtgctccagg tccagctggt gaaccaggtg ctccaggtga agctggtgaa 240
ccaggtccac caggtccagc tggtgctcca ggtccagctg gtgaaccagg tgaagctggt 300
ccaccaggtg ctccaggtcc agctggtgct ccaggtgaac caggtccagc tggtccacca 360
ggtgctgaag gtgctccagg tccagctggt ccagaaggtg aagctggtgc tgaaggtgaa 420
ccaggtgaag ctggtccacc aggtgctcca ggtgaagctg gtgctgaagg tgctccaggt 480
ccagaaggtg aaccaggtga agctggtcca gaaggtgctc caggtccagc tggtgaacca 540
ggtgctccag gtgaagctgg tgaaccaggt ccaccaggtc cagctggtgc tccaggtcca 600
gctggtgaac caggtgaagc tggtccacca ggtgctccag gtccagctgg tgctccaggt 660
gaaccaggtc cagctggtcc accaggtgct gaaggtgctc caggtccagc tggtccagaa 720
ggtgaagctg gtgctgaagg tgaaccaggt gaagctggtc caccaggtgc tccaggtgaa 780
gctggtgctg aaggtgctcc aggtccagaa ggtgaaccag gtgaagctgg tccagaaggt 840
gctccaggtc cagctggtga accaggtgct ccaggtgaag ctggtgaacc aggtccacca 900
ggtccagctg gtgctccagg tccagctggt gaaccaggtg aagctggtcc accaggtgct 960
ccaggtccag ctggtgctcc aggtgaacca ggtccagctg gtccaccagg tgctgaaggt 1020
gctccaggtc cagctggtcc agaaggtgaa gctggtgctg aaggtgaacc aggtgaagct 1080
ggtccaccag gtgctccagg tgaagctggt gctgaaggtg ctccaggtcc agaaggtgaa 1140
ccaggtgaag ctggtccaga aggtgctcca ggtccagctg gtgaaccagg tgctccaggt 1200
gaagctggtg aaccaggtcc accaggtcca gctggtgctc caggtccagc tggtgaacca 1260
ggtgaagctg gtccaccagg tgctccaggt ccagctggtg ctccaggtga accaggtcca 1320
gctggtccac caggtgctga aggtgctcca ggtccagctg gtccagaagg tgaagctggt 1380
gctgaaggtg aaccaggtga agctggtcca ccaggtgctc caggtgaagc tggtgctgaa 1440
ggtgctccag gtccagaagg tgaaccaggt gaagctggtc cagaaggtgc tccaggtcca 1500
gctggtgaac caggtgctcc aggtgaagct ggtgaaccag gtccaccagg tccagctggt 1560
gctccaggtc cagctggtga accaggtgaa gctggtccac caggtgctcc aggtccagct 1620
ggtgctccag gtgaaccagg tccagctggt ccaccaggtg ctgaaggtgc tccaggtcca 1680
gctggtccag aaggtgaagc tggtgctgaa ggtgaaccag gtgaagctgg tccaccaggt 1740
gctccaggtg aagctggtgc tgaaggtgct ccaggtccag aaggtgaacc aggtgaagct 1800
ggtccagaag gtgctccagg tccagctggt gaaccaggtg ctccaggtga agctggtgaa 1860
ccaggtccac caggtccagc tggtgctcca ggtccagctg gtgaaccagg tgaagctggt 1920
ccaccaggtg ctccaggtcc agctggtgct agaaacggtg atcattgtcc attgggtcca 1980
ggtagatgtt gtagattgca tactgttaga gcttctttgg aagatttggg ttgggctgat 2040
tgggttttgt ctccaagaga agttcaagtt actatgtgta ttggtgcttg tccatctcaa 2100
tttagagctg ctaacatgca tgctcaaatt aagacttctt tgcatagatt gaagccagat 2160
actgttccag ctccatgttg tgttccagct tcttacaacc caatggtttt gattcaaaag 2220
actgatactg gtgtttcttt gcaaacttac gatgatttgt tggctaagga ttgtcattgt 2280
att 2283
<210> 297
<211> 761
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 297
Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Glu Ala Gly Ala Pro Gly
1 5 10 15
Pro Glu Gly Ala Ala Gly Glu Pro Gly Pro Glu Gly Glu Glu Gly Glu
20 25 30
Ala Gly Ala Pro Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Pro Ala
35 40 45
Gly Pro Pro Gly Ala Ala Gly Pro Ala Gly Ala Glu Gly Glu Glu Gly
50 55 60
Glu Pro Gly Glu Pro Gly Pro Ala Gly Ala Glu Gly Pro Pro Gly Ala
65 70 75 80
Ala Gly Pro Ala Gly Pro Glu Gly Pro Glu Gly Ala Ala Gly Ala Glu
85 90 95
Gly Glu Glu Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Glu Ala Gly
100 105 110
Pro Pro Gly Glu Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Ala Gly Glu Pro Gly Pro Glu Gly Glu Glu Gly Glu Ala Gly Ala Pro
130 135 140
Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly
145 150 155 160
Ala Ala Gly Pro Ala Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Glu
165 170 175
Pro Gly Pro Ala Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly Pro Ala
180 185 190
Gly Pro Glu Gly Pro Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly
195 200 205
Glu Ala Gly Pro Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Glu
210 215 220
Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Ala Gly Glu Pro
225 230 235 240
Gly Pro Glu Gly Glu Glu Gly Glu Ala Gly Ala Pro Gly Glu Glu Gly
245 250 255
Pro Pro Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly Ala Ala Gly Pro
260 265 270
Ala Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Glu Pro Gly Pro Ala
275 280 285
Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly Pro Ala Gly Pro Glu Gly
290 295 300
Pro Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly Glu Ala Gly Pro
305 310 315 320
Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Glu Ala
325 330 335
Gly Ala Pro Gly Pro Glu Gly Ala Ala Gly Glu Pro Gly Pro Glu Gly
340 345 350
Glu Glu Gly Glu Ala Gly Ala Pro Gly Glu Glu Gly Pro Pro Gly Glu
355 360 365
Ala Gly Pro Ala Gly Pro Pro Gly Ala Ala Gly Pro Ala Gly Ala Glu
370 375 380
Gly Glu Glu Gly Glu Pro Gly Glu Pro Gly Pro Ala Gly Ala Glu Gly
385 390 395 400
Pro Pro Gly Ala Ala Gly Pro Ala Gly Pro Glu Gly Pro Glu Gly Ala
405 410 415
Ala Gly Ala Glu Gly Glu Glu Gly Glu Ala Gly Pro Pro Gly Pro Ala
420 425 430
Gly Glu Ala Gly Pro Pro Gly Glu Ala Gly Glu Ala Gly Ala Pro Gly
435 440 445
Pro Glu Gly Ala Ala Gly Glu Pro Gly Pro Glu Gly Glu Glu Gly Glu
450 455 460
Ala Gly Ala Pro Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Pro Ala
465 470 475 480
Gly Pro Pro Gly Ala Ala Gly Pro Ala Gly Ala Glu Gly Glu Glu Gly
485 490 495
Glu Pro Gly Glu Pro Gly Pro Ala Gly Ala Glu Gly Pro Pro Gly Ala
500 505 510
Ala Gly Pro Ala Gly Pro Glu Gly Pro Glu Gly Ala Ala Gly Ala Glu
515 520 525
Gly Glu Glu Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Glu Ala Gly
530 535 540
Pro Pro Gly Glu Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
545 550 555 560
Ala Gly Glu Pro Gly Pro Glu Gly Glu Glu Gly Glu Ala Gly Ala Pro
565 570 575
Gly Glu Glu Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Pro Pro Gly
580 585 590
Ala Ala Gly Pro Ala Gly Ala Glu Gly Glu Glu Gly Glu Pro Gly Glu
595 600 605
Pro Gly Pro Ala Gly Ala Glu Gly Pro Pro Gly Ala Ala Gly Pro Ala
610 615 620
Gly Pro Glu Gly Pro Glu Gly Ala Ala Gly Ala Glu Gly Glu Glu Gly
625 630 635 640
Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Arg Asn Gly Asp His Cys
645 650 655
Pro Leu Gly Pro Gly Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser
660 665 670
Leu Glu Asp Leu Gly Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val
675 680 685
Gln Val Thr Met Cys Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala
690 695 700
Asn Met His Ala Gln Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp
705 710 715 720
Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val
725 730 735
Leu Ile Gln Lys Thr Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp
740 745 750
Leu Leu Ala Lys Asp Cys His Cys Ile
755 760
<210> 298
<211> 2283
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 298
ggtgaagctg gtccaccagg tgaagctggt gaagctggtg ctccaggtcc agaaggtgct 60
gctggtgaac caggtccaga aggtgaagaa ggtgaagctg gtgctccagg tgaagaaggt 120
ccaccaggtg aagctggtcc agctggtcca ccaggtgctg ctggtccagc tggtgctgaa 180
ggtgaagaag gtgaaccagg tgaaccaggt ccagctggtg ctgaaggtcc accaggtgct 240
gctggtccag ctggtccaga aggtccagaa ggtgctgctg gtgctgaagg tgaagaaggt 300
gaagctggtc caccaggtcc agctggtgaa gctggtccac caggtgaagc tggtgaagct 360
ggtgctccag gtccagaagg tgctgctggt gaaccaggtc cagaaggtga agaaggtgaa 420
gctggtgctc caggtgaaga aggtccacca ggtgaagctg gtccagctgg tccaccaggt 480
gctgctggtc cagctggtgc tgaaggtgaa gaaggtgaac caggtgaacc aggtccagct 540
ggtgctgaag gtccaccagg tgctgctggt ccagctggtc cagaaggtcc agaaggtgct 600
gctggtgctg aaggtgaaga aggtgaagct ggtccaccag gtccagctgg tgaagctggt 660
ccaccaggtg aagctggtga agctggtgct ccaggtccag aaggtgctgc tggtgaacca 720
ggtccagaag gtgaagaagg tgaagctggt gctccaggtg aagaaggtcc accaggtgaa 780
gctggtccag ctggtccacc aggtgctgct ggtccagctg gtgctgaagg tgaagaaggt 840
gaaccaggtg aaccaggtcc agctggtgct gaaggtccac caggtgctgc tggtccagct 900
ggtccagaag gtccagaagg tgctgctggt gctgaaggtg aagaaggtga agctggtcca 960
ccaggtccag ctggtgaagc tggtccacca ggtgaagctg gtgaagctgg tgctccaggt 1020
ccagaaggtg ctgctggtga accaggtcca gaaggtgaag aaggtgaagc tggtgctcca 1080
ggtgaagaag gtccaccagg tgaagctggt ccagctggtc caccaggtgc tgctggtcca 1140
gctggtgctg aaggtgaaga aggtgaacca ggtgaaccag gtccagctgg tgctgaaggt 1200
ccaccaggtg ctgctggtcc agctggtcca gaaggtccag aaggtgctgc tggtgctgaa 1260
ggtgaagaag gtgaagctgg tccaccaggt ccagctggtg aagctggtcc accaggtgaa 1320
gctggtgaag ctggtgctcc aggtccagaa ggtgctgctg gtgaaccagg tccagaaggt 1380
gaagaaggtg aagctggtgc tccaggtgaa gaaggtccac caggtgaagc tggtccagct 1440
ggtccaccag gtgctgctgg tccagctggt gctgaaggtg aagaaggtga accaggtgaa 1500
ccaggtccag ctggtgctga aggtccacca ggtgctgctg gtccagctgg tccagaaggt 1560
ccagaaggtg ctgctggtgc tgaaggtgaa gaaggtgaag ctggtccacc aggtccagct 1620
ggtgaagctg gtccaccagg tgaagctggt gaagctggtg ctccaggtcc agaaggtgct 1680
gctggtgaac caggtccaga aggtgaagaa ggtgaagctg gtgctccagg tgaagaaggt 1740
ccaccaggtg aagctggtcc agctggtcca ccaggtgctg ctggtccagc tggtgctgaa 1800
ggtgaagaag gtgaaccagg tgaaccaggt ccagctggtg ctgaaggtcc accaggtgct 1860
gctggtccag ctggtccaga aggtccagaa ggtgctgctg gtgctgaagg tgaagaaggt 1920
gaagctggtc caccaggtcc agctggtgct agaaacggtg atcattgtcc attgggtcca 1980
ggtagatgtt gtagattgca tactgttaga gcttctttgg aagatttggg ttgggctgat 2040
tgggttttgt ctccaagaga agttcaagtt actatgtgta ttggtgcttg tccatctcaa 2100
tttagagctg ctaacatgca tgctcaaatt aagacttctt tgcatagatt gaagccagat 2160
actgttccag ctccatgttg tgttccagct tcttacaacc caatggtttt gattcaaaag 2220
actgatactg gtgtttcttt gcaaacttac gatgatttgt tggctaagga ttgtcattgt 2280
att 2283
<210> 299
<211> 801
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 299
Gly Pro Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly
1 5 10 15
Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala
20 25 30
Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala
35 40 45
Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly
50 55 60
Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu
65 70 75 80
Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala
85 90 95
Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly
100 105 110
Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro
115 120 125
Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala
130 135 140
Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly
145 150 155 160
Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu
165 170 175
Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro
180 185 190
Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly
195 200 205
Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro
210 215 220
Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala
225 230 235 240
Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly
245 250 255
Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala
260 265 270
Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro
275 280 285
Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly
290 295 300
Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala
305 310 315 320
Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro
325 330 335
Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly
340 345 350
Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro
355 360 365
Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro
370 375 380
Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly
385 390 395 400
Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu
405 410 415
Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala
420 425 430
Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly
435 440 445
Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu
450 455 460
Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala
465 470 475 480
Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly
485 490 495
Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro
500 505 510
Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala
515 520 525
Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly
530 535 540
Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro
545 550 555 560
Pro Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro
565 570 575
Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly
580 585 590
Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu
595 600 605
Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro
610 615 620
Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly
625 630 635 640
Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro
645 650 655
Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala
660 665 670
Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly
675 680 685
Gly Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys
690 695 700
Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp
705 710 715 720
Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala
725 730 735
Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr
740 745 750
Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val
755 760 765
Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly
770 775 780
Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys
785 790 795 800
Ile
<210> 300
<211> 2403
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 300
ggtccacctg gtgctccagg tgaaccaggt ccagctggtc caccaggtgc tgaaggtgct 60
ccaggtccag ctggtccaga aggtgaagct ggtgctgaag gtgaaccagg tgaagctggt 120
ccaccaggtg ctccaggtga agctggtgct gaaggtgctc caggtccaga aggtgaacca 180
ggtgaagctg gtccagaagg tgctccaggt ccagctggtg aaccaggtgc tccaggtgaa 240
gctggtgaac caggtccacc aggtccagct ggtgctccag gtccagctgg tgaaccaggt 300
gaagctggtc caccaggtgc tccaggtcca gctggtccac caggtccagc tggtgctcca 360
ggtgaaccag gtccagctgg tccaccaggt gctgaaggtg ctccaggtcc agctggtcca 420
gaaggtgaag ctggtgctga aggtgaacca ggtgaagctg gtccaccagg tgctccaggt 480
gaagctggtg ctgaaggtgc tccaggtcca gaaggtgaac caggtgaagc tggtccagaa 540
ggtgctccag gtccagctgg tgaaccaggt gctccaggtg aagctggtga accaggtcca 600
ccaggtccag ctggtgctcc aggtccagct ggtgaaccag gtgaagctgg tccaccaggt 660
gctccaggtc cagctggtcc accaggtcca gctggtgctc caggtgaacc aggtccagct 720
ggtccaccag gtgctgaagg tgctccaggt ccagctggtc cagaaggtga agctggtgct 780
gaaggtgaac caggtgaagc tggtccacca ggtgctccag gtgaagctgg tgctgaaggt 840
gctccaggtc cagaaggtga accaggtgaa gctggtccag aaggtgctcc aggtccagct 900
ggtgaaccag gtgctccagg tgaagctggt gaaccaggtc caccaggtcc agctggtgct 960
ccaggtccag ctggtgaacc aggtgaagct ggtccaccag gtgctccagg tccagctggt 1020
ccaccaggtc cagctggtgc tccaggtgaa ccaggtccag ctggtccacc aggtgctgaa 1080
ggtgctccag gtccagctgg tccagaaggt gaagctggtg ctgaaggtga accaggtgaa 1140
gctggtccac caggtgctcc aggtgaagct ggtgctgaag gtgctccagg tccagaaggt 1200
gaaccaggtg aagctggtcc agaaggtgct ccaggtccag ctggtgaacc aggtgctcca 1260
ggtgaagctg gtgaaccagg tccaccaggt ccagctggtg ctccaggtcc agctggtgaa 1320
ccaggtgaag ctggtccacc aggtgctcca ggtccagctg gtccaccagg tccagctggt 1380
gctccaggtg aaccaggtcc agctggtcca ccaggtgctg aaggtgctcc aggtccagct 1440
ggtccagaag gtgaagctgg tgctgaaggt gaaccaggtg aagctggtcc accaggtgct 1500
ccaggtgaag ctggtgctga aggtgctcca ggtccagaag gtgaaccagg tgaagctggt 1560
ccagaaggtg ctccaggtcc agctggtgaa ccaggtgctc caggtgaagc tggtgaacca 1620
ggtccaccag gtccagctgg tgctccaggt ccagctggtg aaccaggtga agctggtcca 1680
ccaggtgctc caggtccagc tggtccacca ggtccagctg gtgctccagg tgaaccaggt 1740
ccagctggtc caccaggtgc tgaaggtgct ccaggtccag ctggtccaga aggtgaagct 1800
ggtgctgaag gtgaaccagg tgaagctggt ccaccaggtg ctccaggtga agctggtgct 1860
gaaggtgctc caggtccaga aggtgaacca ggtgaagctg gtccagaagg tgctccaggt 1920
ccagctggtg aaccaggtgc tccaggtgaa gctggtgaac caggtccacc aggtccagct 1980
ggtgctccag gtccagctgg tgaaccaggt gaagctggtc caccaggtgc tccaggtcca 2040
gctggtccac caggtccagc tggtggagct agaaacggtg atcattgtcc attgggtcca 2100
ggtagatgtt gtagattgca tactgttaga gcttctttgg aagatttggg ttgggctgat 2160
tgggttttgt ctccaagaga agttcaagtt actatgtgta ttggtgcttg tccatctcaa 2220
tttagagctg ctaacatgca tgctcaaatt aagacttctt tgcatagatt gaagccagat 2280
actgttccag ctccatgttg tgttccagct tcttacaacc caatggtttt gattcaaaag 2340
actgatactg gtgtttcttt gcaaacttac gatgatttgt tggctaagga ttgtcattgt 2400
att 2403
<210> 301
<211> 948
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 301
His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn
1 5 10 15
Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
20 25 30
Asp Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu
35 40 45
Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly
50 55 60
Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala
85 90 95
Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly
100 105 110
Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala
115 120 125
Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro
130 135 140
Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly
145 150 155 160
Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro
165 170 175
Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala
180 185 190
Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly
195 200 205
Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro
210 215 220
Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala
225 230 235 240
Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly
245 250 255
Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro
260 265 270
Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro
275 280 285
Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly
290 295 300
Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala
305 310 315 320
Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala
325 330 335
Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly
340 345 350
Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu
355 360 365
Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro
370 375 380
Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly
385 390 395 400
Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu
405 410 415
Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala
420 425 430
Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly
435 440 445
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro
450 455 460
Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu
465 470 475 480
Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly
485 490 495
Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro
500 505 510
Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala
515 520 525
Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly
530 535 540
Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala
545 550 555 560
Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu
565 570 575
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly
580 585 590
Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu
595 600 605
Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro
610 615 620
Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly
625 630 635 640
Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu
645 650 655
Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala
660 665 670
Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly
675 680 685
Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala
690 695 700
Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala
705 710 715 720
Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly
725 730 735
Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro
740 745 750
Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro
755 760 765
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly
770 775 780
Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
785 790 795 800
Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro
805 810 815
Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly
820 825 830
Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu
835 840 845
Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro
850 855 860
Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly
865 870 875 880
Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro
885 890 895
Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro
900 905 910
Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly
915 920 925
Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu
930 935 940
Pro Gly Pro Ala
945
<210> 302
<211> 2844
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 302
catggtgatg gttctttttc tgatgaaatg aacactattt tggataactt ggctgctaga 60
gattttatta actggttgat tcaaactaag attactgatg gtccacctgg tgaagctggt 120
gcacccggac ccgaaggtgc cgaaggagag gctggtgaac ctggacccgc cggtgaacca 180
ggacctgaag gagctccagg tcctcctgga cccgcaggag agcccggtcc tgccggtgct 240
cctggtccac ccggagaagc aggtccagcc ggagctcctg gtgaggctgg tcccccagga 300
cccgctggag ctgaaggtga ggcaggtcca gccggcgctc caggtgagcc aggaccagaa 360
ggtccaccag gagaagctgg agcacccggt cctccaggag cacccggcgc tgaaggagaa 420
cccggtgctc ctggagaacc cggtccagct ggtgaagctg gtgcacccgg acccgaaggt 480
gccgaaggag aggctggtga acctggaccc gccggtgaac caggacctga aggagctcca 540
ggtcctcctg gacccgcagg agagcccggt cctgccggtg ctcctggtcc acccggagaa 600
gcaggtccag ccggagctcc tggtgaggct ggtcccccag gacccgctgg agctgaaggt 660
gaggcaggtc cagccggcgc tccaggtgag ccaggaccag aaggtccacc aggagaagct 720
ggagcacccg gtcctccagg agcacccggc gctgaaggag aacccggtgc tcctggagaa 780
cccggtccag ctggtgaagc tggtgcaccc ggacccgaag gtgccgaagg agaggctggt 840
gaacctggac ccgccggtga accaggacct gaaggagctc caggtcctcc tggacccgca 900
ggagagcccg gtcctgccgg tgctcctggt ccacccggag aagcaggtcc agccggagct 960
cctggtgagg ctggtccccc aggacccgct ggagctgaag gtgaggcagg tccagccggc 1020
gctccaggtg agccaggacc agaaggtcca ccaggagaag ctggagcacc cggtcctcca 1080
ggagcacccg gcgctgaagg agaacccggt gctcctggag aacccggtcc agctggtgaa 1140
gctggtgcac ccggacccga aggtgccgaa ggagaggctg gtgaacctgg acccgccggt 1200
gaaccaggac ctgaaggagc tccaggtcct cctggacccg caggagagcc cggtcctgcc 1260
ggtgctcctg gtccacccgg agaagcaggt ccagccggag ctcctggtga ggctggtccc 1320
ccaggacccg ctggagctga aggtgaggca ggtccagccg gcgctccagg tgagccagga 1380
ccagaaggtc caccaggaga agctggagca cccggtcctc caggagcacc cggcgctgaa 1440
ggagaacccg gtgctcctgg agaacccggt ccagctggtg aagctggtgc acccggaccc 1500
gaaggtgccg aaggagaggc tggtgaacct ggacccgccg gtgaaccagg acctgaagga 1560
gctccaggtc ctcctggacc cgcaggagag cccggtcctg ccggtgctcc tggtccaccc 1620
ggagaagcag gtccagccgg agctcctggt gaggctggtc ccccaggacc cgctggagct 1680
gaaggtgagg caggtccagc cggcgctcca ggtgagccag gaccagaagg tccaccagga 1740
gaagctggag cacccggtcc tccaggagca cccggcgctg aaggagaacc cggtgctcct 1800
ggagaacccg gtccagctgg tgaagctggt gcacccggac ccgaaggtgc cgaaggagag 1860
gctggtgaac ctggacccgc cggtgaacca ggacctgaag gagctccagg tcctcctgga 1920
cccgcaggag agcccggtcc tgccggtgct cctggtccac ccggagaagc aggtccagcc 1980
ggagctcctg gtgaggctgg tcccccagga cccgctggag ctgaaggtga ggcaggtcca 2040
gccggcgctc caggtgagcc aggaccagaa ggtccaccag gagaagctgg agcacccggt 2100
cctccaggag cacccggcgc tgaaggagaa cccggtgctc ctggagaacc cggtccagct 2160
ggtgaagctg gtgcacccgg acccgaaggt gccgaaggag aggctggtga acctggaccc 2220
gccggtgaac caggacctga aggagctcca ggtcctcctg gacccgcagg agagcccggt 2280
cctgccggtg ctcctggtcc acccggagaa gcaggtccag ccggagctcc tggtgaggct 2340
ggtcccccag gacccgctgg agctgaaggt gaggcaggtc cagccggcgc tccaggtgag 2400
ccaggaccag aaggtccacc aggagaagct ggagcacccg gtcctccagg agcacccggc 2460
gctgaaggag aacccggtgc tcctggagaa cccggtccag ctggtgaagc tggtgcaccc 2520
ggacccgaag gtgccgaagg agaggctggt gaacctggac ccgccggtga accaggacct 2580
gaaggagctc caggtcctcc tggacccgca ggagagcccg gtcctgccgg tgctcctggt 2640
ccacccggag aagcaggtcc agccggagct cctggtgagg ctggtccccc aggacccgct 2700
ggagctgaag gtgaggcagg tccagccggc gctccaggtg agccaggacc agaaggtcca 2760
ccaggagaag ctggagcacc cggtcctcca ggagcacccg gcgctgaagg agaacccggt 2820
gctcctggag aacccggtcc agct 2844
<210> 303
<211> 948
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 303
His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn
1 5 10 15
Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
20 25 30
Asp Gly Pro Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro
35 40 45
Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly
50 55 60
Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu
65 70 75 80
Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala
85 90 95
Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro
115 120 125
Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala
130 135 140
Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly
145 150 155 160
Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu
165 170 175
Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro
180 185 190
Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly
195 200 205
Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala
210 215 220
Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro
225 230 235 240
Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly
245 250 255
Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
260 265 270
Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu
275 280 285
Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly
290 295 300
Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu
305 310 315 320
Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro
325 330 335
Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly
340 345 350
Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala
355 360 365
Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro
370 375 380
Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly
385 390 395 400
Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro
405 410 415
Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu
420 425 430
Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly
435 440 445
Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro Gly Pro
450 455 460
Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly Pro Pro
465 470 475 480
Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly
485 490 495
Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro
500 505 510
Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala
515 520 525
Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly
530 535 540
Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro
545 550 555 560
Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly Pro Pro
565 570 575
Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu Ala Gly
580 585 590
Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala
595 600 605
Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro
610 615 620
Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly
625 630 635 640
Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala
645 650 655
Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro
660 665 670
Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu Pro Gly
675 680 685
Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Glu
690 695 700
Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala
705 710 715 720
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly
725 730 735
Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu
740 745 750
Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu
755 760 765
Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly
770 775 780
Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala Gly Glu
785 790 795 800
Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Glu Pro
805 810 815
Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly
820 825 830
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala
835 840 845
Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu
850 855 860
Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly
865 870 875 880
Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro
885 890 895
Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Glu Ala
900 905 910
Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly
915 920 925
Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro
930 935 940
Pro Gly Pro Ala
945
<210> 304
<211> 2844
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 304
catggtgatg gttctttttc tgatgaaatg aacactattt tggataactt ggctgctaga 60
gattttatta actggttgat tcaaactaag attactgatg gtccacctgg tgctccaggt 120
gaaccaggtc cagctggtcc accaggtgct gaaggtgctc caggtccagc tggtccagaa 180
ggtgaagctg gtgctgaagg tgaaccaggt gaagctggtc caccaggtgc tccaggtgaa 240
gctggtgctg aaggtgctcc aggtccagaa ggtgaaccag gtgaagctgg tccagaaggt 300
gctccaggtc cagctggtga accaggtgct ccaggtgaag ctggtgaacc aggtccacca 360
ggtccagctg gtgctccagg tccagctggt gaaccaggtg aagctggtcc accaggtgct 420
ccaggtccag ctggtccacc aggtccagct ggtgctccag gtgaaccagg tccagctggt 480
ccaccaggtg ctgaaggtgc tccaggtcca gctggtccag aaggtgaagc tggtgctgaa 540
ggtgaaccag gtgaagctgg tccaccaggt gctccaggtg aagctggtgc tgaaggtgct 600
ccaggtccag aaggtgaacc aggtgaagct ggtccagaag gtgctccagg tccagctggt 660
gaaccaggtg ctccaggtga agctggtgaa ccaggtccac caggtccagc tggtgctcca 720
ggtccagctg gtgaaccagg tgaagctggt ccaccaggtg ctccaggtcc agctggtcca 780
ccaggtccag ctggtgctcc aggtgaacca ggtccagctg gtccaccagg tgctgaaggt 840
gctccaggtc cagctggtcc agaaggtgaa gctggtgctg aaggtgaacc aggtgaagct 900
ggtccaccag gtgctccagg tgaagctggt gctgaaggtg ctccaggtcc agaaggtgaa 960
ccaggtgaag ctggtccaga aggtgctcca ggtccagctg gtgaaccagg tgctccaggt 1020
gaagctggtg aaccaggtcc accaggtcca gctggtgctc caggtccagc tggtgaacca 1080
ggtgaagctg gtccaccagg tgctccaggt ccagctggtc caccaggtcc agctggtgct 1140
ccaggtgaac caggtccagc tggtccacca ggtgctgaag gtgctccagg tccagctggt 1200
ccagaaggtg aagctggtgc tgaaggtgaa ccaggtgaag ctggtccacc aggtgctcca 1260
ggtgaagctg gtgctgaagg tgctccaggt ccagaaggtg aaccaggtga agctggtcca 1320
gaaggtgctc caggtccagc tggtgaacca ggtgctccag gtgaagctgg tgaaccaggt 1380
ccaccaggtc cagctggtgc tccaggtcca gctggtgaac caggtgaagc tggtccacca 1440
ggtgctccag gtccagctgg tccaccaggt ccagctggtg ctccaggtga accaggtcca 1500
gctggtccac caggtgctga aggtgctcca ggtccagctg gtccagaagg tgaagctggt 1560
gctgaaggtg aaccaggtga agctggtcca ccaggtgctc caggtgaagc tggtgctgaa 1620
ggtgctccag gtccagaagg tgaaccaggt gaagctggtc cagaaggtgc tccaggtcca 1680
gctggtgaac caggtgctcc aggtgaagct ggtgaaccag gtccaccagg tccagctggt 1740
gctccaggtc cagctggtga accaggtgaa gctggtccac caggtgctcc aggtccagct 1800
ggtccaccag gtccagctgg tgctccaggt gaaccaggtc cagctggtcc accaggtgct 1860
gaaggtgctc caggtccagc tggtccagaa ggtgaagctg gtgctgaagg tgaaccaggt 1920
gaagctggtc caccaggtgc tccaggtgaa gctggtgctg aaggtgctcc aggtccagaa 1980
ggtgaaccag gtgaagctgg tccagaaggt gctccaggtc cagctggtga accaggtgct 2040
ccaggtgaag ctggtgaacc aggtccacca ggtccagctg gtgctccagg tccagctggt 2100
gaaccaggtg aagctggtcc accaggtgct ccaggtccag ctggtccacc aggtccagct 2160
ggtgctccag gtgaaccagg tccagctggt ccaccaggtg ctgaaggtgc tccaggtcca 2220
gctggtccag aaggtgaagc tggtgctgaa ggtgaaccag gtgaagctgg tccaccaggt 2280
gctccaggtg aagctggtgc tgaaggtgct ccaggtccag aaggtgaacc aggtgaagct 2340
ggtccagaag gtgctccagg tccagctggt gaaccaggtg ctccaggtga agctggtgaa 2400
ccaggtccac caggtccagc tggtgctcca ggtccagctg gtgaaccagg tgaagctggt 2460
ccaccaggtg ctccaggtcc agctggtcca ccaggtccag ctggtgctcc aggtgaacca 2520
ggtccagctg gtccaccagg tgctgaaggt gctccaggtc cagctggtcc agaaggtgaa 2580
gctggtgctg aaggtgaacc aggtgaagct ggtccaccag gtgctccagg tgaagctggt 2640
gctgaaggtg ctccaggtcc agaaggtgaa ccaggtgaag ctggtccaga aggtgctcca 2700
ggtccagctg gtgaaccagg tgctccaggt gaagctggtg aaccaggtcc accaggtcca 2760
gctggtgctc caggtccagc tggtgaacca ggtgaagctg gtccaccagg tgctccaggt 2820
ccagctggtc caccaggtcc agct 2844
<210> 305
<211> 948
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 305
His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn
1 5 10 15
Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr
20 25 30
Asp Gly Pro Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro
35 40 45
Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly
50 55 60
Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu
65 70 75 80
Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala
85 90 95
Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly
100 105 110
Pro Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Glu Pro Gly Ala
115 120 125
Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala
130 135 140
Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly
145 150 155 160
Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu
165 170 175
Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro
180 185 190
Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly
195 200 205
Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala
210 215 220
Pro Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Glu Pro
225 230 235 240
Gly Ala Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly
245 250 255
Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
260 265 270
Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu
275 280 285
Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly
290 295 300
Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu
305 310 315 320
Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro
325 330 335
Gly Ala Pro Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly
340 345 350
Glu Pro Gly Ala Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro Gly Ala
355 360 365
Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Glu Pro
370 375 380
Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro Ala Gly
385 390 395 400
Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala Gly Pro
405 410 415
Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly Pro Glu
420 425 430
Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro Ala Gly
435 440 445
Glu Pro Gly Ala Pro Gly Pro Pro Gly Glu Pro Gly Pro Ala Gly Glu
450 455 460
Ala Gly Glu Pro Gly Ala Pro Gly Pro Ala Gly Glu Ala Gly Pro Pro
465 470 475 480
Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly
485 490 495
Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro Gly Pro
500 505 510
Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly Glu Ala
515 520 525
Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala Pro Gly
530 535 540
Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro Gly Pro
545 550 555 560
Ala Gly Glu Pro Gly Ala Pro Gly Pro Pro Gly Glu Pro Gly Pro Ala
565 570 575
Gly Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro Ala Gly Glu Ala Gly
580 585 590
Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala Gly Ala
595 600 605
Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly Ala Pro
610 615 620
Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu Pro Gly
625 630 635 640
Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu Gly Ala
645 650 655
Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly Ala Pro
660 665 670
Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Pro Pro Gly Glu Pro Gly
675 680 685
Pro Ala Gly Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro Ala Gly Glu
690 695 700
Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly Pro Ala
705 710 715 720
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala Glu Gly
725 730 735
Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu Gly Glu
740 745 750
Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly Ala Glu
755 760 765
Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro Glu Gly
770 775 780
Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Pro Pro Gly Glu
785 790 795 800
Pro Gly Pro Ala Gly Glu Ala Gly Glu Pro Gly Ala Pro Gly Pro Ala
805 810 815
Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly
820 825 830
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Pro Pro Gly Ala
835 840 845
Glu Gly Ala Pro Gly Pro Ala Gly Pro Glu Gly Glu Ala Gly Ala Glu
850 855 860
Gly Glu Pro Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Glu Ala Gly
865 870 875 880
Ala Glu Gly Ala Pro Gly Pro Glu Gly Glu Pro Gly Glu Ala Gly Pro
885 890 895
Glu Gly Ala Pro Gly Pro Ala Gly Glu Pro Gly Ala Pro Gly Pro Pro
900 905 910
Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Glu Pro Gly Ala Pro Gly
915 920 925
Pro Ala Gly Glu Ala Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro
930 935 940
Pro Gly Pro Ala
945
<210> 306
<211> 2844
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 306
catggtgatg gttctttttc tgatgaaatg aacactattt tggataactt ggctgctaga 60
gattttatta actggttgat tcaaactaag attactgatg gtccacctgg tgctccaggt 120
gaaccaggtc cagctggtcc accaggtgct gaaggtgctc caggtccagc tggtccagaa 180
ggtgaagctg gtgctgaagg tgaaccaggt gaagctggtc caccaggtgc tccaggtgaa 240
gctggtgctg aaggtgctcc aggtccagaa ggtgaaccag gtgaagctgg tccagaaggt 300
gctccaggtc cagctggtga accaggtgct ccaggtccac caggtgaacc aggtccagct 360
ggtgaagctg gtgaaccagg tgctccaggt ccagctggtg aagctggtcc accaggtgct 420
ccaggtccag ctggtccacc aggtccagct ggtgctccag gtgaaccagg tccagctggt 480
ccaccaggtg ctgaaggtgc tccaggtcca gctggtccag aaggtgaagc tggtgctgaa 540
ggtgaaccag gtgaagctgg tccaccaggt gctccaggtg aagctggtgc tgaaggtgct 600
ccaggtccag aaggtgaacc aggtgaagct ggtccagaag gtgctccagg tccagctggt 660
gaaccaggtg ctccaggtcc accaggtgaa ccaggtccag ctggtgaagc tggtgaacca 720
ggtgctccag gtccagctgg tgaagctggt ccaccaggtg ctccaggtcc agctggtcca 780
ccaggtccag ctggtgctcc aggtgaacca ggtccagctg gtccaccagg tgctgaaggt 840
gctccaggtc cagctggtcc agaaggtgaa gctggtgctg aaggtgaacc aggtgaagct 900
ggtccaccag gtgctccagg tgaagctggt gctgaaggtg ctccaggtcc agaaggtgaa 960
ccaggtgaag ctggtccaga aggtgctcca ggtccagctg gtgaaccagg tgctccaggt 1020
ccaccaggtg aaccaggtcc agctggtgaa gctggtgaac caggtgctcc aggtccagct 1080
ggtgaagctg gtccaccagg tgctccaggt ccagctggtc caccaggtcc agctggtgct 1140
ccaggtgaac caggtccagc tggtccacca ggtgctgaag gtgctccagg tccagctggt 1200
ccagaaggtg aagctggtgc tgaaggtgaa ccaggtgaag ctggtccacc aggtgctcca 1260
ggtgaagctg gtgctgaagg tgctccaggt ccagaaggtg aaccaggtga agctggtcca 1320
gaaggtgctc caggtccagc tggtgaacca ggtgctccag gtccaccagg tgaaccaggt 1380
ccagctggtg aagctggtga accaggtgct ccaggtccag ctggtgaagc tggtccacca 1440
ggtgctccag gtccagctgg tccaccaggt ccagctggtg ctccaggtga accaggtcca 1500
gctggtccac caggtgctga aggtgctcca ggtccagctg gtccagaagg tgaagctggt 1560
gctgaaggtg aaccaggtga agctggtcca ccaggtgctc caggtgaagc tggtgctgaa 1620
ggtgctccag gtccagaagg tgaaccaggt gaagctggtc cagaaggtgc tccaggtcca 1680
gctggtgaac caggtgctcc aggtccacca ggtgaaccag gtccagctgg tgaagctggt 1740
gaaccaggtg ctccaggtcc agctggtgaa gctggtccac caggtgctcc aggtccagct 1800
ggtccaccag gtccagctgg tgctccaggt gaaccaggtc cagctggtcc accaggtgct 1860
gaaggtgctc caggtccagc tggtccagaa ggtgaagctg gtgctgaagg tgaaccaggt 1920
gaagctggtc caccaggtgc tccaggtgaa gctggtgctg aaggtgctcc aggtccagaa 1980
ggtgaaccag gtgaagctgg tccagaaggt gctccaggtc cagctggtga accaggtgct 2040
ccaggtccac caggtgaacc aggtccagct ggtgaagctg gtgaaccagg tgctccaggt 2100
ccagctggtg aagctggtcc accaggtgct ccaggtccag ctggtccacc aggtccagct 2160
ggtgctccag gtgaaccagg tccagctggt ccaccaggtg ctgaaggtgc tccaggtcca 2220
gctggtccag aaggtgaagc tggtgctgaa ggtgaaccag gtgaagctgg tccaccaggt 2280
gctccaggtg aagctggtgc tgaaggtgct ccaggtccag aaggtgaacc aggtgaagct 2340
ggtccagaag gtgctccagg tccagctggt gaaccaggtg ctccaggtcc accaggtgaa 2400
ccaggtccag ctggtgaagc tggtgaacca ggtgctccag gtccagctgg tgaagctggt 2460
ccaccaggtg ctccaggtcc agctggtcca ccaggtccag ctggtgctcc aggtgaacca 2520
ggtccagctg gtccaccagg tgctgaaggt gctccaggtc cagctggtcc agaaggtgaa 2580
gctggtgctg aaggtgaacc aggtgaagct ggtccaccag gtgctccagg tgaagctggt 2640
gctgaaggtg ctccaggtcc agaaggtgaa ccaggtgaag ctggtccaga aggtgctcca 2700
ggtccagctg gtgaaccagg tgctccaggt ccaccaggtg aaccaggtcc agctggtgaa 2760
gctggtgaac caggtgctcc aggtccagct ggtgaagctg gtccaccagg tgctccaggt 2820
ccagctggtc caccaggtcc agct 2844
<210> 307
<211> 815
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 307
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
130 135 140
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
165 170 175
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
180 185 190
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
210 215 220
Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu
225 230 235 240
Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly
245 250 255
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
260 265 270
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro
275 280 285
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
290 295 300
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu
305 310 315 320
Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro
325 330 335
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly
340 345 350
Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu
355 360 365
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
370 375 380
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly
385 390 395 400
Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu
405 410 415
Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro
420 425 430
Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly
435 440 445
Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala
450 455 460
Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala
465 470 475 480
Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly
485 490 495
Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro
500 505 510
Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu
515 520 525
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly
530 535 540
Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala
545 550 555 560
Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala
565 570 575
Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly
580 585 590
Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
595 600 605
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
610 615 620
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
625 630 635 640
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
645 650 655
Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
660 665 670
Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly
675 680 685
Gly Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly
690 695 700
Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn
705 710 715 720
Ala Arg Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp
725 730 735
Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val
740 745 750
Asn Ala Ala Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala
755 760 765
Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp
770 775 780
Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile
785 790 795 800
Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala
805 810 815
<210> 308
<211> 2445
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 308
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc tggtgaagct 360
ggtgcacccg gacccgaagg tgccgaagga gaggctggtg aacctggacc cgccggtgaa 420
ccaggacctg aaggagctcc aggtcctcct ggacccgcag gagagcccgg tcctgccggt 480
gctcctggtc cacccggaga agcaggtcca gccggagctc ctggtgaggc tggtccccca 540
ggacccgctg gagctgaagg tgaggcaggt ccagccggcg ctccaggtga gccaggacca 600
gaaggtccac caggagaagc tggagcaccc ggtcctccag gagcacccgg cgctgaagga 660
gaacccggtg ctcctggaga acccggtcca gctggtgaag ctggtgcacc cggacccgaa 720
ggtgccgaag gagaggctgg tgaacctgga cccgccggtg aaccaggacc tgaaggagct 780
ccaggtcctc ctggacccgc aggagagccc ggtcctgccg gtgctcctgg tccacccgga 840
gaagcaggtc cagccggagc tcctggtgag gctggtcccc caggacccgc tggagctgaa 900
ggtgaggcag gtccagccgg cgctccaggt gagccaggac cagaaggtcc accaggagaa 960
gctggagcac ccggtcctcc aggagcaccc ggcgctgaag gagaacccgg tgctcctgga 1020
gaacccggtc cagctggtga agctggtgca cccggacccg aaggtgccga aggagaggct 1080
ggtgaacctg gacccgccgg tgaaccagga cctgaaggag ctccaggtcc tcctggaccc 1140
gcaggagagc ccggtcctgc cggtgctcct ggtccacccg gagaagcagg tccagccgga 1200
gctcctggtg aggctggtcc cccaggaccc gctggagctg aaggtgaggc aggtccagcc 1260
ggcgctccag gtgagccagg accagaaggt ccaccaggag aagctggagc acccggtcct 1320
ccaggagcac ccggcgctga aggagaaccc ggtgctcctg gagaacccgg tccagctggt 1380
gaagctggtg cacccggacc cgaaggtgcc gaaggagagg ctggtgaacc tggacccgcc 1440
ggtgaaccag gacctgaagg agctccaggt cctcctggac ccgcaggaga gcccggtcct 1500
gccggtgctc ctggtccacc cggagaagca ggtccagccg gagctcctgg tgaggctggt 1560
cccccaggac ccgctggagc tgaaggtgag gcaggtccag ccggcgctcc aggtgagcca 1620
ggaccagaag gtccaccagg agaagctgga gcacccggtc ctccaggagc acccggcgct 1680
gaaggagaac ccggtgctcc tggagaaccc ggtccagctg gtgaagctgg tgcacccgga 1740
cccgaaggtg ccgaaggaga ggctggtgaa cctggacccg ccggtgaacc aggacctgaa 1800
ggagctccag gtcctcctgg acccgcagga gagcccggtc ctgccggtgc tcctggtcca 1860
cccggagaag caggtccagc cggagctcct ggtgaggctg gtcccccagg acccgctgga 1920
gctgaaggtg aggcaggtcc agccggcgct ccaggtgagc caggaccaga aggtccacca 1980
ggagaagctg gagcacccgg tcctccagga gcacccggcg ctgaaggaga acccggtgct 2040
cctggagaac ccggtccagc tggtggaggt tctgatttgg ataagaagtt gttggaagct 2100
gctagagctg gtcaagatga tgaagttaga attttgatgg ctaacggtgc tgatgttaac 2160
gctagagatt ctactggttg gactccattg catttggctg ctccatgggg tcatccagaa 2220
attgttgaag ttttgttgaa gaacggtgct gatgttaacg ctgctgattt tcaaggttgg 2280
actccattgc atttggctgc tgctgttggt catttggaaa ttgttgaagt tttgttgaag 2340
tacggtgctg atgttaacgc tcaagataag tttggtaaga ctgcttttga tatttctatt 2400
gataacggta acgaagattt ggctgaaatt ttgcaaaagg ctgct 2445
<210> 309
<211> 1157
<212> PRT
<213> 人工序列(Artificial Sequence)
<400> 309
Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
1 5 10 15
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
20 25 30
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
35 40 45
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
50 55 60
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
65 70 75 80
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
85 90 95
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
100 105 110
Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala
115 120 125
Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu
130 135 140
Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly
145 150 155 160
Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu
165 170 175
Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala
180 185 190
Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly
195 200 205
Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala
210 215 220
Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu
225 230 235 240
Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly
245 250 255
Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro
260 265 270
Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro
275 280 285
Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly
290 295 300
Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu
305 310 315 320
Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro
325 330 335
Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly
340 345 350
Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu
355 360 365
Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro
370 375 380
Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly
385 390 395 400
Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu
405 410 415
Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro
420 425 430
Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly
435 440 445
Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala Gly Ala
450 455 460
Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly Pro Ala
465 470 475 480
Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro Ala Gly
485 490 495
Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala Gly Pro
500 505 510
Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly Ala Glu
515 520 525
Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro Glu Gly
530 535 540
Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro Gly Ala
545 550 555 560
Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly Glu Ala
565 570 575
Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu Pro Gly
580 585 590
Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro Gly Pro
595 600 605
Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly Glu Ala
610 615 620
Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro Ala Gly
625 630 635 640
Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro Gly Pro
645 650 655
Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly Ala Pro
660 665 670
Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro Ala Gly
675 680 685
Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala Gly Glu
690 695 700
Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly Pro Pro
705 710 715 720
Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro Pro Gly
725 730 735
Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro Gly Pro
740 745 750
Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Pro
755 760 765
Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro Pro Gly
770 775 780
Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro Gly Pro
785 790 795 800
Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly Glu Ala
805 810 815
Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala Pro Gly
820 825 830
Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro Gly Pro
835 840 845
Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly Pro Pro
850 855 860
Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly
865 870 875 880
Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro Gly Pro
885 890 895
Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly Glu Pro
900 905 910
Gly Pro Ala Gly Glu Ala Gly Ala Pro Gly Pro Glu Gly Ala Glu Gly
915 920 925
Glu Ala Gly Glu Pro Gly Pro Ala Gly Glu Pro Gly Pro Glu Gly Ala
930 935 940
Pro Gly Pro Pro Gly Pro Ala Gly Glu Pro Gly Pro Ala Gly Ala Pro
945 950 955 960
Gly Pro Pro Gly Glu Ala Gly Pro Ala Gly Ala Pro Gly Glu Ala Gly
965 970 975
Pro Pro Gly Pro Ala Gly Ala Glu Gly Glu Ala Gly Pro Ala Gly Ala
980 985 990
Pro Gly Glu Pro Gly Pro Glu Gly Pro Pro Gly Glu Ala Gly Ala Pro
995 1000 1005
Gly Pro Pro Gly Ala Pro Gly Ala Glu Gly Glu Pro Gly Ala Pro Gly
1010 1015 1020
Glu Pro Gly Pro Ala Gly Gly Gly Ser Asp Leu Asp Lys Lys Leu Leu
1025 1030 1035 1040
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala
1045 1050 1055
Asn Gly Ala Asp Val Asn Ala Arg Asp Ser Thr Gly Trp Thr Pro Leu
1060 1065 1070
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu
1075 1080 1085
Lys Asn Gly Ala Asp Val Asn Ala Ala Asp Phe Gln Gly Trp Thr Pro
1090 1095 1100
Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu
1105 1110 1115 1120
Leu Lys Tyr Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr
1125 1130 1135
Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile
1140 1145 1150
Leu Gln Lys Ala Ala
1155
<210> 310
<211> 3471
<212> DNA
<213> 人工序列(Artificial Sequence)
<400> 310
ggtccacctg gtgaagctgg tgcacccgga cccgaaggtg ccgaaggaga ggctggtgaa 60
cctggacccg ccggtgaacc aggacctgaa ggagctccag gtcctcctgg acccgcagga 120
gagcccggtc ctgccggtgc tcctggtcca cccggagaag caggtccagc cggagctcct 180
ggtgaggctg gtcccccagg acccgctgga gctgaaggtg aggcaggtcc agccggcgct 240
ccaggtgagc caggaccaga aggtccacca ggagaagctg gagcacccgg tcctccagga 300
gcacccggcg ctgaaggaga acccggtgct cctggagaac ccggtccagc tggtgaagct 360
ggtgcacccg gacccgaagg tgccgaagga gaggctggtg aacctggacc cgccggtgaa 420
ccaggacctg aaggagctcc aggtcctcct ggacccgcag gagagcccgg tcctgccggt 480
gctcctggtc cacccggaga agcaggtcca gccggagctc ctggtgaggc tggtccccca 540
ggacccgctg gagctgaagg tgaggcaggt ccagccggcg ctccaggtga gccaggacca 600
gaaggtccac caggagaagc tggagcaccc ggtcctccag gagcacccgg cgctgaagga 660
gaacccggtg ctcctggaga acccggtcca gctggtgaag ctggtgcacc cggacccgaa 720
ggtgccgaag gagaggctgg tgaacctgga cccgccggtg aaccaggacc tgaaggagct 780
ccaggtcctc ctggacccgc aggagagccc ggtcctgccg gtgctcctgg tccacccgga 840
gaagcaggtc cagccggagc tcctggtgag gctggtcccc caggacccgc tggagctgaa 900
ggtgaggcag gtccagccgg cgctccaggt gagccaggac cagaaggtcc accaggagaa 960
gctggagcac ccggtcctcc aggagcaccc ggcgctgaag gagaacccgg tgctcctgga 1020
gaacccggtc cagctggtga agctggtgca cccggacccg aaggtgccga aggagaggct 1080
ggtgaacctg gacccgccgg tgaaccagga cctgaaggag ctccaggtcc tcctggaccc 1140
gcaggagagc ccggtcctgc cggtgctcct ggtccacccg gagaagcagg tccagccgga 1200
gctcctggtg aggctggtcc cccaggaccc gctggagctg aaggtgaggc aggtccagcc 1260
ggcgctccag gtgagccagg accagaaggt ccaccaggag aagctggagc acccggtcct 1320
ccaggagcac ccggcgctga aggagaaccc ggtgctcctg gagaacccgg tccagctggt 1380
gaagctggtg cacccggacc cgaaggtgcc gaaggagagg ctggtgaacc tggacccgcc 1440
ggtgaaccag gacctgaagg agctccaggt cctcctggac ccgcaggaga gcccggtcct 1500
gccggtgctc ctggtccacc cggagaagca ggtccagccg gagctcctgg tgaggctggt 1560
cccccaggac ccgctggagc tgaaggtgag gcaggtccag ccggcgctcc aggtgagcca 1620
ggaccagaag gtccaccagg agaagctgga gcacccggtc ctccaggagc acccggcgct 1680
gaaggagaac ccggtgctcc tggagaaccc ggtccagctg gtgaagctgg tgcacccgga 1740
cccgaaggtg ccgaaggaga ggctggtgaa cctggacccg ccggtgaacc aggacctgaa 1800
ggagctccag gtcctcctgg acccgcagga gagcccggtc ctgccggtgc tcctggtcca 1860
cccggagaag caggtccagc cggagctcct ggtgaggctg gtcccccagg acccgctgga 1920
gctgaaggtg aggcaggtcc agccggcgct ccaggtgagc caggaccaga aggtccacca 1980
ggagaagctg gagcacccgg tcctccagga gcacccggcg ctgaaggaga acccggtgct 2040
cctggagaac ccggtccagc tggtgaagct ggtgcacccg gacccgaagg tgccgaagga 2100
gaggctggtg aacctggacc cgccggtgaa ccaggacctg aaggagctcc aggtcctcct 2160
ggacccgcag gagagcccgg tcctgccggt gctcctggtc cacccggaga agcaggtcca 2220
gccggagctc ctggtgaggc tggtccccca ggacccgctg gagctgaagg tgaggcaggt 2280
ccagccggcg ctccaggtga gccaggacca gaaggtccac caggagaagc tggagcaccc 2340
ggtcctccag gagcacccgg cgctgaagga gaacccggtg ctcctggaga acccggtcca 2400
gctggtgaag ctggtgcacc cggacccgaa ggtgccgaag gagaggctgg tgaacctgga 2460
cccgccggtg aaccaggacc tgaaggagct ccaggtcctc ctggacccgc aggagagccc 2520
ggtcctgccg gtgctcctgg tccacccgga gaagcaggtc cagccggagc tcctggtgag 2580
gctggtcccc caggacccgc tggagctgaa ggtgaggcag gtccagccgg cgctccaggt 2640
gagccaggac cagaaggtcc accaggagaa gctggagcac ccggtcctcc aggagcaccc 2700
ggcgctgaag gagaacccgg tgctcctgga gaacccggtc cagctggtga agctggtgca 2760
cccggacccg aaggtgccga aggagaggct ggtgaacctg gacccgccgg tgaaccagga 2820
cctgaaggag ctccaggtcc tcctggaccc gcaggagagc ccggtcctgc cggtgctcct 2880
ggtccacccg gagaagcagg tccagccgga gctcctggtg aggctggtcc cccaggaccc 2940
gctggagctg aaggtgaggc aggtccagcc ggcgctccag gtgagccagg accagaaggt 3000
ccaccaggag aagctggagc acccggtcct ccaggagcac ccggcgctga aggagaaccc 3060
ggtgctcctg gagaacccgg tccagctggt ggaggttctg atttggataa gaagttgttg 3120
gaagctgcta gagctggtca agatgatgaa gttagaattt tgatggctaa cggtgctgat 3180
gttaacgcta gagattctac tggttggact ccattgcatt tggctgctcc atggggtcat 3240
ccagaaattg ttgaagtttt gttgaagaac ggtgctgatg ttaacgctgc tgattttcaa 3300
ggttggactc cattgcattt ggctgctgct gttggtcatt tggaaattgt tgaagttttg 3360
ttgaagtacg gtgctgatgt taacgctcaa gataagtttg gtaagactgc ttttgatatt 3420
tctattgata acggtaacga agatttggct gaaattttgc aaaaggctgc t 3471

Claims (18)

1.一种类明胶单元，具有以下重复结构：
(G-X-Y)n
其中，G为甘氨酸，X和Y各自独立选自脯氨酸、丙氨酸和谷氨酸；n为5-20的整数，优选n为6-20或9-15的整数。
2.如权利要求1所述的类明胶单元，其特征在于，所述类明胶单元由选自以下的两种或两种以上的G-X-Y三元单体重复结构组成：GPP、GEE、GAA、GEA、GAE、GAP、GPA、GPE和GEP。
3.如权利要求1所述的类明胶单元，其特征在于，所述类明胶单元选自SEQ ID NO:17-89中任一奇数编号的序列所示的类明胶单元。
4.一种类明胶蛋白，其特征在于，所述类明胶蛋白的核心结构为：U1-U2或U1-U2-…Ua，其中，U1、U2、…、Ua各自代表权利要求1-3中任一项所述的任意一种类明胶单元，a为≥3的整数，且所述类明胶单元相同或不同。
5.如权利要求4所述的类明胶蛋白，其特征在于，所述核心结构的氨基酸残基总数占该类明胶蛋白氨基酸残基总数的70％以上，较佳80％以上，更佳85％以上，进一步更佳90％以上、95％以上或99％以上。
6.如权利要求4或5所述的类明胶蛋白，其特征在于，
所述类明胶蛋白中，丙氨酸的含量大于等于10％；和/或
所述类明胶单元中，代表亲水性的GRAVY值大于-1.1。
7.如权利要求6所述的类明胶蛋白，其特征在于，
所述类明胶蛋白中，丙氨酸的含量在10-45％的范围内；和/或
所述类明胶蛋白中，代表亲水性的GRAVY值小于等于0。
8.如权利要求4-7中任一项所述的类明胶蛋白，其特征在于，所述类明胶蛋白具有100-2000个氨基酸。
9.如权利要求4-8中任一项所述的类明胶蛋白，其特征在于，
所述类明胶蛋白的凝冻强度≤10g；和/或
所述类明胶蛋白的粘度≤3mPa·s。
10.如权利要求4所述的类明胶蛋白，其特征在于，所述类明胶蛋白的氨基酸序列选自：
(1)SEQ ID NO:91-185中任一奇数编号所示的氨基酸序列；
(2)含两条或两条以上(1)所述的氨基酸序列的氨基酸序列；和
(3)与(1)或(2)所述的氨基酸序列具有80％以上同一性百分比、优选85％以上同一性百分比、更优选90％以上同一性百分比、更优选95％以上同一性百分比的氨基酸序列。
11.一种融合蛋白，其特征在于，所述融合蛋白含有权利要求4-10中任一项所述的类明胶蛋白和生物活性蛋白。
12.如权利要求11所述的融合蛋白，其特征在于，所述生物活性蛋白选自：酶、酶抑制剂、抗原、抗体、激素、凝血因子、干扰素、细胞因子、生长因子、分化因子、骨组织生长有关的因子、与骨质因子吸收相关的因子、趋化因子、细胞运动因子、移动因子、静止因子、抗真菌因子、血浆黏附分子、间质黏附分子、细胞外基质、受体配基及其片段。
13.如权利要求11所述的融合蛋白，其特征在于，所述融合蛋白的氨基酸序列选自与选自SEQ ID NO:211-239、247-259和263-309中任一奇数编号所示的氨基酸序列具有80％以上同一性百分比、优选85％以上同一性百分比、更优选90％以上同一性百分比、更优选95％以上同一性百分比的氨基酸序列。
14.一种多核苷酸序列，选自：
(1)编码权利要求1-3中任一项所述的类明胶单元、权利要求4-10中任一项所述的类明胶蛋白或权利要求11-13中任一项所述的融合蛋白的多核苷酸序列；和
(2)(1)所述多核苷酸序列的互补序列。
15.一种核酸构建体，其包含权利要求14所述的多核苷酸序列；
优选地，所述核酸构建体为克隆载体或表达载体。
16.一种宿主细胞，其特征在于，所述宿主细胞：
(1)含有权利要求14所述的多核苷酸序列，和/或含有权利要求15所述的核酸构建体；和/或
(2)表达权利要求1-3中任一项所述的类明胶单元、权利要求4-10中任一项所述的类明胶蛋白和/或权利要求11-13中任一项所述的融合蛋白。
17.选自以下的应用：
(1)权利要求1-3中任一项所述的类明胶单元或其编码序列或该编码序列的互补序列在制备类明胶蛋白或含该类明胶蛋白的融合蛋白中的应用；
(2)权利要求4-10中任一项所述的类明胶蛋白或其编码序列或该编码序列的互补序列在制备含有该类明胶蛋白的融合蛋白中的应用，或在提高生物活性蛋白的药代动力学和/或增强生物活性蛋白的理化性质中的应用；
(3)权利要求11-13中任一项所述的融合蛋白、其编码序列或含该编码序列或其互补序列的核酸构建体在制备药物中的应用。
18.甘氨酸、脯氨酸、丙氨酸和谷氨酸在制备能改善生物活性蛋白的生物学性质或生物学功能的载体蛋白中的应用。
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