CN111012875A

CN111012875A - Chinese medicinal preparation for treating acute and chronic nephritis

Info

Publication number: CN111012875A
Application number: CN201911371857.3A
Authority: CN
Inventors: 吴育文
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-12-26
Filing date: 2019-12-26
Publication date: 2020-04-17

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine preparation for treating acute and chronic nephritis, which is prepared from the following traditional Chinese medicine components in parts by weight: prepared rhizome of rehmannia: 18-20 parts; cornus officinalis: 9-11 parts; astragalus root: 25-30 parts; motherwort: 10-15 parts; peach kernel: 5-7 parts; corn silk: 12-17 parts; the white paint comprises the following components: 10-16 parts; plantain seed: 6-10 parts; rhizoma alismatis: 10-15 parts; chinese yam: 8-12 parts; cicada shell: 3-5 parts; and (3) perilla leaves: 6-10 parts; cortex moutan: 10-15 parts, it has effects of tonifying liver and kidney, promoting urination and detumescence, invigorating spleen and reinforcing kidney, dispelling pathogenic wind and dispersing lung qi, clearing away heat and toxic material, promoting blood circulation and removing blood stasis, and improve human immunity, its administration is safe and reliable, can treat acute and chronic nephritis effectively, and difficult recurrence in the course of treatment, the treatment time is short, the therapeutic effect is good, can prevent the emergence of uremia effectively, the state of an illness can be controlled in time, and shorten the renal repair phase.

Description

Chinese medicinal preparation for treating acute and chronic nephritis

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating acute and chronic nephritis.

Background

The physiological functions of the kidney are mainly to excrete metabolites, regulate water, electrolytes and acid-base balance, secrete various active substances, and maintain the stable environment in the body so as to ensure the normal physiological functions of the body. Nephritis is mediated by immune and inflammatory mediators, and finally causes inflammatory changes of intrinsic tissues of the kidney, so that a group of kidney diseases causing different degrees of renal function decline can be caused by various causes. Non-immune and non-inflammatory mechanisms are also involved in the chronic process.

Nephritis is a common disease seriously harming human health, and various nephritis has the characteristics of soft legs, lumbago and difficult cure of patients, particularly severe nephritis, which can cause uremia after long-term treatment and death of patients in serious cases. At present, the western medicines for treating nephritis have the following problems: the treatment effect is not obvious, the relapse is easy, and the treatment effect is poor; the patients are dialyzed for a long time, take hormone medicines and anti-inflammatory medicines, cause in-vivo disorder, have long treatment time, are very likely to cause uremia and even death, and are not cured of economic burden after repeated treatment.

The Chinese herbal medicine is a natural plant, has no side effect, has double effects of treatment and health care, and has better curative effect on nephritis. At present, there is also a technical scheme for treating nephritis by using traditional Chinese medicine, for example, patent granted by invention of china, publication number is CN104689216B, publication date is 2018, 2 months and 16 days, and discloses a medicine for treating chronic nephritis, which is prepared from traditional Chinese medicine as raw material, and the medicine is prepared from angelica sinensis, rhizoma atractylodis macrocephalae, astragalus membranaceus, poria cocos, yam, radix achyranthis bidentatae, semen plantaginis, oldenlandia diffusa, edible tulip, patrinia heterophylla, honeysuckle, humifuse euphorbia herb, herba artemisiae capillaris, polygonum cuspidatum, radix paeoniae rubra, winged euonymus twig, fructus lycii, dogwood, cassia twig, nutmeg, fructus amomi and. The invention achieves the effect of treating chronic nephritis by utilizing the effects of invigorating yang and spleen, tonifying kidney and eliminating dampness, inducing diuresis to alleviate edema and nourishing liver and kidney among the traditional Chinese medicine components.

Disclosure of the invention

The invention aims to provide a traditional Chinese medicine preparation for treating acute and chronic nephritis for public health, which is safe and reliable to take, can effectively treat nephritis, is not easy to repeat in the treatment process, has short treatment time, little pain of patients and good treatment effect, can effectively prevent uremia, can control the state of illness in time, and shortens the kidney repair period.

In order to achieve the above purpose, the technical problem solved by the present invention is realized by adopting the following technical scheme:

the invention provides a traditional Chinese medicine preparation for treating acute and chronic nephritis, which is characterized in that: the raw materials comprise the following traditional Chinese medicine components in parts by weight: prepared rhizome of rehmannia: 18-20 parts; cornus officinalis: 9-11 parts; astragalus root: 25-30 parts; motherwort: 10-15 parts; peach kernel: 5-7 parts; corn silk: 12-17 parts; the white paint comprises the following components: 10-16 parts; plantain seed: 6-10 parts; rhizoma alismatis: 10-15 parts; chinese yam: 8-12 parts; cicada shell: 3-5 parts; and (3) perilla leaves: 6-10 parts; cortex moutan: 10-15 parts.

Preferably, the raw materials of the traditional Chinese medicine preparation for treating acute and chronic nephritis comprise the following traditional Chinese medicine components in parts by weight: prepared rhizome of rehmannia: 18 parts of a mixture; cornus officinalis: 10 parts of (A); astragalus root: 25 parts of (1); motherwort: 12 parts of (1); peach kernel: 6 parts of (1); corn silk: 15 parts of (1); the white paint comprises the following components: 12 parts of (1); plantain seed: 8 parts of a mixture; rhizoma alismatis: 12 parts of (1); chinese yam: 10 parts of (A); cicada shell: 4 parts of a mixture; and (3) perilla leaves: 8 parts of a mixture; cortex moutan: 12 parts.

Preferably, the raw materials of the traditional Chinese medicine preparation for treating acute and chronic nephritis comprise the following traditional Chinese medicine components in parts by weight: prepared rhizome of rehmannia: 20 parts of (1); cornus officinalis: 9 parts of (1); astragalus root: 28 parts of (1); motherwort: 10 parts of (A); peach kernel: 5 parts of a mixture; corn silk: 12 parts of (1); the white paint comprises the following components: 10 parts of (A); plantain seed: 6 parts of (1); rhizoma alismatis: 10 parts of (A); chinese yam: 12 parts of (1); cicada shell: 5 parts of a mixture; and (3) perilla leaves: 10 parts of (A); cortex moutan: 15 parts.

Preferably, the raw materials of the traditional Chinese medicine preparation for treating acute and chronic nephritis comprise the following traditional Chinese medicine components in parts by weight: prepared rhizome of rehmannia: 20 parts of (1); cornus officinalis: 11 parts of (1); astragalus root: 30 parts of (1); motherwort: 15 parts of (1); peach kernel: 7 parts; corn silk: 17 parts of (1); the white paint comprises the following components: 16 parts of a mixture; plantain seed: 10 parts of (A); rhizoma alismatis: 15 parts of (1); chinese yam: 8 parts of a mixture; cicada shell: 3 parts of a mixture; and (3) perilla leaves: 6 parts of (1); cortex moutan: 10 parts.

The drug effect of the traditional Chinese medicine of the invention is as follows:

prepared rhizome of rehmannia: the Chinese herbal medicine recorded in the book of materia medica, prepared rhizome of rehmannia nourishes kidney water, seals and fills bone marrow, benefits blood vessels, tonifies true yin, improves hearing and eyesight, blackens hair and blackens beard. Can also tonify spleen yin, stop chronic diarrhea, treat overstrain wind arthralgia, yin deficiency fever, dry cough with phlegm, short breath, dyspnea, deficiency of stomach qi and discouraging, acne syndrome with no pus due to heart deficiency, shin and thigh ache after illness, postpartum umbilical and abdominal pain, cold syndrome with yin deficiency, no sweat and constipation, various bleeding, all liver and kidney yin deficiency, deficiency and all diseases, and is the main medicine for strengthening water.

Cornus officinalis: the product has sour and astringent taste, is slightly warm, enters liver and kidney meridians, has effects of invigorating liver and kidney, astringing and fixing color, and warming and invigorating kidney yang, and can be used for invigorating kidney and benefiting liver, arresting seminal emission and arresting sweating, liver and kidney deficiency, waist soreness and nocturnal emission, dizziness, frequent micturition, and spontaneous perspiration.

Astragalus root: "the recipe of property of a medicine song" cloud: astragalus (same as astragalus) is used as a tonic and has the effects of benefiting vital qi, strengthening spleen and stomach, discharging pus, relieving pain, activating blood and treating danger. Has obvious curative effect on diseases such as exterior deficiency spontaneous perspiration, internal injury due to qi deficiency, listlessness, myasthenia of limbs, spleen deficiency diarrhea, body deficiency hyperhidrosis, qi deficiency rectocele, prolapse of sub-organs, edema, carbuncle and cellulitis and the like. Ancient books of treatises on the supplement of qi and deficiency, such as Ming Yi Bie Lu and Ben Cao gang mu, etc.

Motherwort: the motherwort herb is pungent, bitter and cool in taste, can be used as a medicine by the whole herb, has the effective component of leonurine, contains various alkaloids such as leonurine, stachydrine, leonuridine, leonurine and the like, benzoic acid, potassium chloride and the like, has the effects of activating blood, removing blood stasis, eliminating water, carbuncle swelling and sore and has the effects of inducing diuresis and reducing swelling.

Peach kernel: has the effects of promoting blood circulation, removing blood stasis, loosening bowel to relieve constipation, and relieving cough and asthma. Can be used for treating abdominal lump, pulmonary abscess, intestinal dryness, constipation, cough and asthma.

Corn silk: has good diuretic effect, and can improve kidney ability, remarkably relieve edema of body, and improve urination obstruction.

Achyranthes bidentata: achyranthes bidentata contains a large amount of alkaloids, and has the functions of tonifying liver and kidney, strengthening muscles and bones, dredging channels and collaterals and dissipating blood stasis. The book Ben Cao gang mu records achyranthes bidentata: the nourishing effect is like the force of cattle. The achyranthes root, radix achyranthis bidentatae, with bitter and sour flavor, is mainly used for treating cold-dampness flaccidity arthralgia, limb spasm, gonalgia, difficulty in flexion and extension, blood and qi expelling, heat and fire erosion injury, weight reduction and aging resistance after long-term taking.

Plantain seed: the product has sweet and cold nature and flavor, enters kidney, bladder, liver and lung channels, and has the functions of promoting diuresis, treating stranguria, excreting dampness, relieving diarrhea, clearing liver-fire, improving eyesight, clearing heat and eliminating phlegm.

Rhizoma alismatis: can be used for treating nephritis, edema, pyelonephritis, enteritis, diarrhea, dysuresia, etc.

Chinese yam: sweet in taste and neutral in nature, entering lung, spleen and kidney meridians; it has effects of invigorating spleen, tonifying lung, invigorating stomach, invigorating kidney, strengthening kidney, replenishing vital essence, improving hearing and eyesight, strengthening tendons and bones, tranquilizing mind, and prolonging life, and can be used for treating weakness of spleen and stomach, listlessness, asthenia, anorexia, chronic diarrhea, lung qi dryness, phlegm asthma, cough, kidney qi deficiency, soreness of waist and knees, debility of lower limbs, diabetes, nocturnal emission, premature ejaculation, leukorrhagia, red swelling of skin, and obesity.

Cicada shell: is cold in nature, has effects of clearing heat and dispelling pathogenic wind, enhancing immunity, relieving inflammation, dispelling pathogenic wind and removing dampness, and inducing diuresis to alleviate edema.

And (3) perilla leaves: has the effects of dispelling exterior cold and promoting sweating, and can be used for treating wind-cold exterior syndrome with symptoms of aversion to cold, fever, anhidrosis, etc. Perilla frutescens, pungent and fragrant, warm in nature, enters lung and runs superficies to disperse wind-cold, and runs spleen and blood to relieve epigastric distention, so it has the actions of relieving superficies, dispelling cold, moving qi and relieving epigastric distention.

Cortex moutan: bitter and pungent in taste, slightly cold in nature, and has effects of clearing heat, cooling blood, promoting blood circulation and removing blood stasis. Paeonol and other glycosides contained in cortex moutan have antibacterial and antiinflammatory effects. Meanwhile, paeonol also has central inhibition effects of tranquilizing, cooling, relieving fever, relieving pain, relieving spasm, etc., and has effects of resisting atherosclerosis, diuresis, resisting ulcer, etc.

The invention has the beneficial effects that: according to the principles of traditional Chinese medicine dialectical treatment and therapeutic method and prescription, according to the efficacy requirements, the Chinese medicinal composition has the effects of tonifying liver and kidney, inducing diuresis to reduce edema, invigorating spleen and reinforcing kidney, dispelling wind and dispersing lung qi, clearing heat and removing toxicity, and activating blood circulation to remove blood stasis, and can improve human immunity, condition human liver, spleen, lung and kidney, and enable the five organs and six entrails of human body to tend to balance yin and yang. The Chinese medicinal composition is safe and reliable to take, can effectively treat acute and chronic nephritis, is not easy to repeat in the treatment process, has short treatment time, little pain of patients and good treatment effect, can effectively prevent uremia, can control the state of illness in time, and shortens the kidney repair period.

The prescription for treating the acute and chronic nephritis of the invention inherits the essence of the traditional Chinese medicine, and the pharmacology of the prescription is as follows: the prescription components have scientific and reasonable proportion, follow the principle of 'monarch, minister, assistant and guide', take the prepared rhizome of rehmannia, the pulp of dogwood fruit, the corn stigma and the achyranthes bidentata as monarch drugs, and have the efficacies of nourishing kidney water and tonifying liver and kidney; the astragalus, the motherwort, the corn stigma, the plantain seed and the alisma orientale are taken as ministerial medicines, so that the effects of tonifying middle-jiao and Qi, inducing diuresis to reduce edema, improving the kidney function and inducing diuresis to treat stranguria are achieved; the yam and the perilla leaves are used as adjuvant drugs, and the Chinese yam and the perilla leaves have the effects of tonifying spleen and lung, reinforcing stomach and kidney, reinforcing kidney and replenishing vital essence, entering the lung and walking outside to disperse wind cold, and walking spleen and blood to widen the middle; the peach kernel, the cicada shell and the cortex moutan are taken as guiding drugs, and the Chinese medicinal composition has the effects of activating blood circulation, removing stasis, clearing heat, dispelling wind, removing dampness, resisting bacteria and resisting inflammation.

Detailed Description

The present invention is further illustrated by the following examples, which are intended to be purely exemplary and are not intended to be limiting.

The invention relates to a traditional Chinese medicine preparation for treating acute and chronic nephritis, which is prepared from the following traditional Chinese medicine components in parts by weight: prepared rhizome of rehmannia: 18-20 parts; cornus officinalis: 9-11 parts; astragalus root: 25-30 parts; motherwort: 10-15 parts; peach kernel: 5-7 parts; corn silk: 12-17 parts; the white paint comprises the following components: 10-16 parts; plantain seed: 6-10 parts; rhizoma alismatis: 10-15 parts; chinese yam: 8-12 parts; cicada shell: 3-5 parts; and (3) perilla leaves: 6-10 parts; cortex moutan: 10-15 parts.

The preparation method of the traditional Chinese medicine preparation for treating acute and chronic nephritis comprises the following steps: firstly, prepared rehmannia root, cornus officinalis, astragalus, motherwort, peach kernel, corn stigma, Chinese lacquer, plantain seed, alisma orientale, Chinese yam, cicada shell, perilla leaf and cortex moutan which are weighed according to the traditional Chinese medicine components are added with water for decoction and extraction, and then the decoction is filtered, the filtrate is combined and concentrated to be taken.

Example 1:

the traditional Chinese medicine preparation for treating acute and chronic nephritis according to the invention comprises the following raw materials in parts by weight: prepared rhizome of rehmannia: 18 parts of a mixture; cornus officinalis: 10 parts of (A); astragalus root: 25 parts of (1); motherwort: 12 parts of (1); peach kernel: 6 parts of (1); corn silk: 15 parts of (1); the white paint comprises the following components: 12 parts of (1); plantain seed: 8 parts of a mixture; rhizoma alismatis: 12 parts of (1); chinese yam: 10 parts of (A); cicada shell: 4 parts of a mixture; and (3) perilla leaves: 8 parts of a mixture; cortex moutan: 12 parts.

Example 2:

the traditional Chinese medicine preparation for treating acute and chronic nephritis according to the invention comprises the following raw materials in parts by weight: prepared rhizome of rehmannia: 20 parts of (1); cornus officinalis: 9 parts of (1); astragalus root: 28 parts of (1); motherwort: 10 parts of (A); peach kernel: 5 parts of a mixture; corn silk: 12 parts of (1); the white paint comprises the following components: 10 parts of (A); plantain seed: 6 parts of (1); rhizoma alismatis: 10 parts of (A); chinese yam: 12 parts of (1); cicada shell: 5 parts of a mixture; and (3) perilla leaves: 10 parts of (A); cortex moutan: 15 parts.

Example 3:

the traditional Chinese medicine preparation for treating acute and chronic nephritis according to the invention comprises the following raw materials in parts by weight: prepared rhizome of rehmannia: 20 parts of (1); cornus officinalis: 11 parts of (1); astragalus root: 30 parts of (1); motherwort: 15 parts of (1); peach kernel: 7 parts; corn silk: 17 parts of (1); the white paint comprises the following components: 16 parts of a mixture; plantain seed: 10 parts of (A); rhizoma alismatis: 15 parts of (1); chinese yam: 8 parts of a mixture; cicada shell: 3 parts of a mixture; and (3) perilla leaves: 6 parts of (1); cortex moutan: 10 parts.

In order to show the clinical effect of the medicine for treating acute and chronic nephritis, 100 cases of western hormone medicines and 100 cases of nephritis treated by using the medicine are compared.

Diagnostic criteria for nephritis: the patients have symptoms of headache, dizziness, myasthenia of limbs, waist soreness and backache, urine protein increase and the like, and all the cases are patients clinically diagnosed with nephritis.

The judgment standard of the curative effect is as follows: the symptoms disappear, and the patient feels that the legs and the feet are powerful and the waist is not sore; effective, symptom-reducing; no effect, no reduction or worsening of symptoms.

The medicine is used for treatment, and three months are a treatment course.

The test group comprises 100 cases, wherein 82 cases of men and 18 cases of women are treated by using the medicament of the invention at the age of 18-66 years. Three months is a course of treatment.

A control group comprises 100 male patients and 18 female patients, wherein the age of the control group is 18-66 years, and the control group is treated by using common hormone prednisone in Western medicine. The method of administration is in accordance with the instructions.

The two groups of cases are basically equivalent in disease conditions, age and the like and have comparability.

Therapeutic effect comparison table

As can be seen from the above table, the treatment effect of the medicine of the invention is greatly superior to the effect of the common medicine in western medicine. And the follow-up is carried out half a year after the treatment, and the recurrence rate of the cured case is only 8.2%.

Clinical application

The preparation for treating acute and chronic nephritis is used for treating and observing 100 patients or volunteers. The 3 prepared samples of the examples were used in the following 2 different types of patients or volunteers, respectively. (A is a control group; B is an experimental group) A is a control group: acute nephritis, which is mainly manifested by acute hematuria, proteinuria, edema and hypertension, accompanied by renal function decline (total 100 cases, 82 cases in male, 18 cases in female, average age 35.2 years); experiment group B: chronic nephritis is characterized by proteinuria, hematuria, edema, hypertension, renal insufficiency or anemia (total 100 cases, 82 cases in male, 18 cases in female, average age 37.5 years). Not less than 20 cases were used for each of the above two types of samples. As a result: control group a: 15 cases are cured, 20 cases are improved, 65 cases are invalid, and the effective rate is 35 percent; experiment group B: 85 cases are cured, 10 cases are improved, 5 cases are not effective, and the effective rate is 95.0%. The results show that: the preparation for treating acute and chronic nephritis is safe and effective to use, has good curative effect on acute and chronic nephritis, can effectively relieve the pain of patients, and achieves the purpose of improving the life quality.

The following are 3 typical cases:

case 1: huangxxx, male, 37 years old, has symptoms of debilitation, waist pain, anorexia, edema, hypertension, and urine volume decrease, and is diagnosed as acute nephritis by hospital. When the preparation for treating nephritis (example 1) of the present invention is taken 100ml each time, 3 times a day, and continuously taken for 90 days, all the symptoms disappear, and the renal function returns to normal and is cured.

Case 2: qinxxx, female, 27 years old, with hematuria, hypodynamia, pale complexion, hypomnesis as the main symptoms, and the chronic nephritis is diagnosed by hospital examination. After the preparation for treating nephritis (example 2) of the present invention was taken 100ml each time, 3 times a day, and 60 days continuously, all the symptoms disappeared and were cured.

Case 3: in xxx, male, age 43, weakness, low back pain, anorexia, gross hematuria, edema, hypertension, renal dysfunction, hypofunction, congestive heart failure. The chronic nephritis is diagnosed by hospital examination. When the preparation for treating nephritis (example 3) of the present invention is taken 100ml each time, 3 times a day, and continuously taken for 90 days, all the symptoms disappear and are cured.

It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are intended to be within the scope of the invention.

Claims

1. A traditional Chinese medicine preparation for treating acute and chronic nephritis is characterized in that: the raw materials comprise the following traditional Chinese medicine components in parts by weight: prepared rhizome of rehmannia: 18-20 parts; cornus officinalis: 9-11 parts; astragalus root: 25-30 parts; motherwort: 10-15 parts; peach kernel: 5-7 parts; corn silk: 12-17 parts; the white paint comprises the following components: 10-16 parts; plantain seed: 6-10 parts; rhizoma alismatis: 10-15 parts; chinese yam: 8-12 parts; cicada shell: 3-5 parts; and (3) perilla leaves: 6-10 parts; cortex moutan: 10-15 parts.

2. The traditional Chinese medicine preparation for treating acute and chronic nephritis according to claim 1, characterized in that: the raw materials comprise the following traditional Chinese medicine components in parts by weight: prepared rhizome of rehmannia: 18 parts of a mixture; cornus officinalis: 10 parts of (A); astragalus root: 25 parts of (1); motherwort: 12 parts of (1); peach kernel: 6 parts of (1); corn silk: 15 parts of (1); the white paint comprises the following components: 12 parts of (1); plantain seed: 8 parts of a mixture; rhizoma alismatis: 12 parts of (1); chinese yam: 10 parts of (A); cicada shell: 4 parts of a mixture; and (3) perilla leaves: 8 parts of a mixture; cortex moutan: 12 parts.

3. The traditional Chinese medicine preparation for treating acute and chronic nephritis according to claim 1, characterized in that: the raw materials comprise the following traditional Chinese medicine components in parts by weight: prepared rhizome of rehmannia: 20 parts of (1); cornus officinalis: 9 parts of (1); astragalus root: 28 parts of (1); motherwort: 10 parts of (A); peach kernel: 5 parts of a mixture; corn silk: 12 parts of (1); the white paint comprises the following components: 10 parts of (A); plantain seed: 6 parts of (1); rhizoma alismatis: 10 parts of (A); chinese yam: 12 parts of (1); cicada shell: 5 parts of a mixture; and (3) perilla leaves: 10 parts of (A); cortex moutan: 15 parts.

4. The traditional Chinese medicine preparation for treating acute and chronic nephritis according to claim 1, characterized in that: the raw materials comprise the following traditional Chinese medicine components in parts by weight: prepared rhizome of rehmannia: 20 parts of (1); cornus officinalis: 11 parts of (1); astragalus root: 30 parts of (1); motherwort: 15 parts of (1); peach kernel: 7 parts; corn silk: 17 parts of (1); the white paint comprises the following components: 16 parts of a mixture; plantain seed: 10 parts of (A); rhizoma alismatis: 15 parts of (1); chinese yam: 8 parts of a mixture; cicada shell: 3 parts of a mixture; and (3) perilla leaves: 6 parts of (1); cortex moutan: 10 parts.