CN110917340A - Composition for treating dry and itching skin and skin care ointment thereof - Google Patents
Composition for treating dry and itching skin and skin care ointment thereof Download PDFInfo
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- CN110917340A CN110917340A CN201911218489.9A CN201911218489A CN110917340A CN 110917340 A CN110917340 A CN 110917340A CN 201911218489 A CN201911218489 A CN 201911218489A CN 110917340 A CN110917340 A CN 110917340A
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- skin
- mixture
- hirudin
- honeysuckle
- borneol
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- 239000000203 mixture Substances 0.000 title claims abstract description 39
- 208000003251 Pruritus Diseases 0.000 title claims abstract description 33
- 239000002674 ointment Substances 0.000 title claims abstract description 24
- 230000007803 itching Effects 0.000 title description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 50
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 32
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 20
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 17
- 102000007625 Hirudins Human genes 0.000 claims abstract description 17
- 108010007267 Hirudins Proteins 0.000 claims abstract description 17
- 240000001341 Reynoutria japonica Species 0.000 claims abstract description 17
- 235000018167 Reynoutria japonica Nutrition 0.000 claims abstract description 17
- 229940069521 aloe extract Drugs 0.000 claims abstract description 17
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 claims abstract description 17
- 229940006607 hirudin Drugs 0.000 claims abstract description 17
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 16
- 229940116229 borneol Drugs 0.000 claims abstract description 16
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 16
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 16
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229940046009 vitamin E Drugs 0.000 claims abstract description 16
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 16
- 239000011709 vitamin E Substances 0.000 claims abstract description 16
- 238000002156 mixing Methods 0.000 claims abstract description 15
- 239000000706 filtrate Substances 0.000 claims abstract description 12
- 238000003756 stirring Methods 0.000 claims abstract description 12
- 206010013786 Dry skin Diseases 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 230000037336 dry skin Effects 0.000 claims abstract description 7
- 238000001816 cooling Methods 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 230000036620 skin dryness Effects 0.000 claims abstract description 6
- 230000001954 sterilising effect Effects 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 5
- 241001289529 Fallopia multiflora Species 0.000 claims abstract description 3
- 239000003814 drug Substances 0.000 abstract description 4
- 230000000694 effects Effects 0.000 description 11
- 235000011187 glycerol Nutrition 0.000 description 11
- 230000001737 promoting effect Effects 0.000 description 7
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000000034 method Methods 0.000 description 4
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- 238000012986 modification Methods 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 238000006748 scratching Methods 0.000 description 2
- 230000002393 scratching effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- AFHJQYHRLPMKHU-XXWVOBANSA-N Aloin Natural products O=C1c2c(O)cc(CO)cc2[C@H]([C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)c2c1c(O)ccc2 AFHJQYHRLPMKHU-XXWVOBANSA-N 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 244000183685 Citrus aurantium Species 0.000 description 1
- 235000007716 Citrus aurantium Nutrition 0.000 description 1
- 235000005976 Citrus sinensis Nutrition 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- CPUHNROBVJNNPW-UHFFFAOYSA-N aloin A Natural products OC1C(O)C(O)C(CO)OC1OC1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 CPUHNROBVJNNPW-UHFFFAOYSA-N 0.000 description 1
- AFHJQYHRLPMKHU-WEZNYRQKSA-N aloin B Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@H]1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-WEZNYRQKSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- AFHJQYHRLPMKHU-UHFFFAOYSA-N isobarbaloin Natural products OC1C(O)C(O)C(CO)OC1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-UHFFFAOYSA-N 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000001314 paroxysmal effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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Abstract
The invention discloses a composition for treating skin dryness and pruritus and a skin-care ointment thereof, and relates to the technical field of skin medicaments and preparation thereof. The composition for treating skin dryness and pruritus comprises the following raw materials in parts by weight: 0.2 to 0.5 portion of hirudin, 0.6 to 1.5 portions of aloe extract, 0.1 to 0.3 portion of prepared fleece-flower root, 0.1 to 0.3 portion of honeysuckle, 0.8 to 1 portion of glycerol, 0.6 to 1 portion of vitamin E and 0.1 to 0.3 portion of borneol. The invention also can be skin-care ointment for treating dry skin and pruritus, which is prepared by the following steps: mixing the prepared polygonum multiflorum and the honeysuckle according to the weight ratio of 1:1, adding 6-10 times of water, decocting for 2 hours, and filtering to obtain filtrate I; uniformly stirring hirudin and aloe extract at a weight ratio of 1:3, sterilizing at 80-90 deg.C for 10min to obtain mixture I; mixing the filtrate I and the mixture I, adding glycerol, and homogenizing at 80-90 deg.C with a vacuum homogenizer to obtain a mixture II; cooling the mixture II to room temperature, adding vitamin E and borneol while stirring, and preparing into colloidal ointment.
Description
Technical Field
The invention relates to the technical field of skin medicines and preparation thereof, in particular to a composition for treating dry and itching skin and a skin-care ointment thereof.
Background
Itching caused by dry skin is a dermatological condition in which there is no primary skin damage but the skin is itchy, typically systemic or local. The disease is frequently caused in dry seasons of autumn and winter, whether men, women, old and young can get ill, excessive bathing or alternate cold and hot stimulation can be caused, the clinical manifestation is paroxysmal skin itch, particularly severe at night, and patients have general itch especially on limbs. Scratching of the skin can be caused by scratching, secondary damage such as blood scab or pigmentation can be caused seriously, and tinea skin injury can be caused secondarily if the skin is infected by fungi or for a long time.
The dry and itching skin generally relates to large area and long duration, but hormone medicines and antibiotic medicines are not suitable for large area or continuous use, and no special treatment method for the dry and itching skin clinically exists at present.
Patent CN103238834B discloses a composition for treating skin itch and a preparation method thereof, the composition is composed of peach kernel extract, seville orange flower extract, mulberry leaf extract, perilla leaf extract and dark plum fruit extract, and the purposes of relieving skin allergy and skin itch are achieved by regulating blood, promoting blood circulation, dispelling wind and relieving exterior syndrome and inhibiting the generation of allergic factors in vivo. The purpose of treatment is achieved by oral administration.
Disclosure of Invention
The invention aims to provide a composition for treating dry and itching skin and skin-care ointment thereof, which have the effects of dispelling wind, relieving itching and nourishing skin, do not contain hormones and antibiotics, are safe and non-toxic, have small side effect when being externally used on the skin and have remarkable curative effect.
In order to solve the technical problems, the invention adopts the following technical scheme: a composition for dry and itchy skin characterized by: comprises the following raw materials in parts by weight: 0.2 to 0.5 portion of hirudin, 0.6 to 1.5 portions of aloe extract, 0.1 to 0.3 portion of prepared fleece-flower root, 0.1 to 0.3 portion of honeysuckle, 0.8 to 1 portion of glycerol, 0.6 to 1 portion of vitamin E and 0.1 to 0.3 portion of borneol.
The further technical scheme is that the raw materials of the components by weight are as follows: 0.4 part of hirudin, 1.2 parts of aloe extract, 0.2 part of prepared fleece-flower root, 0.2 part of honeysuckle flower, 0.9 part of glycerol, 0.8 part of vitamin E and 0.2 part of borneol.
The invention also provides a skin-care ointment for treating dry and itching skin, which is characterized by comprising the following components in parts by weight: the preparation method comprises the following steps:
1) mixing the prepared polygonum multiflorum and the honeysuckle according to the weight ratio of 1:1, adding 6-10 times of water, decocting for 2 hours, and filtering to obtain filtrate I;
2) uniformly stirring hirudin and aloe extract at a weight ratio of 1:3, sterilizing at 80-90 deg.C, inactivating enzyme for 10min to obtain mixture I;
3) mixing the filtrate I obtained in the step 1) and the mixture I obtained in the step 2), adding glycerol, and homogenizing at 80-90 ℃ by using a vacuum homogenizer to obtain a mixture II;
4) cooling the mixture II to room temperature, adding vitamin E and borneol while stirring, and preparing into colloidal ointment.
Wherein the functions of the raw materials are as follows:
hirudin: has effects in promoting blood circulation, dispelling blood stasis, promoting skin microcirculation, relieving skin, promoting skin absorption of other medicinal components, promoting local metabolism, and improving skin immunity;
aloe extract: contains a large amount of aloin, and has effects of keeping moisture, eliminating inflammation, inhibiting bacteria, relieving itching, resisting allergy, and softening skin;
preparing fleece-flower root: has effects in nourishing yin, nourishing blood, dispelling pathogenic wind, and removing toxic substances;
honeysuckle flower: disperse wind-heat, clear away heat and toxic material;
glycerol: moistening skin and keeping moisture;
and D, vitamin E: promoting blood circulation, and accelerating cell repair and regeneration;
borneol: clearing away heat and toxic material.
Compared with the prior art, the invention has the beneficial effects that: the composition and the skin care ointment are safe, have no toxic or side effect, are used for treating dry skin and pruritus, are externally applied to skin pruritus parts, are easy to absorb by skin, have the effects of dispelling wind, removing toxicity, resisting bacteria and relieving itching, and simultaneously nourish the skin, condition the skin, enhance the skin immunity, effectively consolidate the treatment effect and avoid repeated disease conditions.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
The composition for treating the dry skin pruritus comprises the following raw materials in parts by weight: 0.2 part of hirudin, 0.6 part of aloe extract, 0.1 part of prepared fleece-flower root, 0.1 part of honeysuckle flower, 0.8 part of glycerol, 0.6 part of vitamin E and 0.1 part of borneol.
Example 2
The composition for treating the dry skin pruritus comprises the following raw materials in parts by weight: 0.4 part of hirudin, 1.2 parts of aloe extract, 0.2 part of prepared fleece-flower root, 0.2 part of honeysuckle flower, 0.9 part of glycerol, 0.8 part of vitamin E and 0.2 part of borneol.
Example 3
The composition for treating the dry skin pruritus comprises the following raw materials in parts by weight: 0.5 part of hirudin, 1.5 parts of aloe extract, 0.3 part of prepared fleece-flower root, 0.3 part of honeysuckle flower, 1 part of glycerol, 1 part of vitamin E and 0.3 part of borneol.
Example 4
A skin care ointment for treating skin dryness and pruritus is prepared by the following steps:
1) respectively taking 10g of prepared fleece-flower root and honeysuckle, mixing the prepared fleece-flower root and the honeysuckle, adding 6 times of water, decocting for 2 hours, and filtering to obtain filtrate I;
2) mixing hirudin 20g and Aloe extract 60g, stirring, sterilizing at 80 deg.C for 10min to obtain mixture I;
3) mixing the filtrate I obtained in the step 1) and the mixture I obtained in the step 2), adding 80g of glycerol, and homogenizing at 80 ℃ by using a vacuum homogenizer to obtain a mixture II;
4) cooling the mixture II to room temperature, adding 60g of vitamin E and 10g of borneol while stirring, and preparing the colloidal ointment.
The use method comprises the following steps: the ointment is applied to the affected part three times a day for 7 days as a treatment course.
Example 5
A skin care ointment for treating skin dryness and pruritus is prepared by the following steps:
1) respectively taking 20g of prepared fleece-flower root and honeysuckle, mixing the prepared fleece-flower root and the honeysuckle, adding 7 times of water, decocting for 2 hours, and filtering to obtain filtrate I;
2) mixing hirudin 40g and Aloe extract 120g, stirring, sterilizing at 85 deg.C for 10min to obtain mixture I;
3) mixing the filtrate I obtained in the step 1) and the mixture I obtained in the step 2), adding 90g of glycerol, and homogenizing at 90 ℃ by using a vacuum homogenizer to obtain a mixture II;
4) cooling the mixture II to room temperature, adding 80g of vitamin E and 20g of borneol while stirring, and preparing the colloidal ointment.
The use method comprises the following steps: the ointment is applied to the affected part three times a day for 7 days as a treatment course.
Example 6
A skin care ointment for treating skin dryness and pruritus is prepared by the following steps:
1) respectively taking 30g of prepared fleece-flower root and honeysuckle, mixing the prepared fleece-flower root and the honeysuckle, adding 8 times of water, decocting for 2 hours, and filtering to obtain filtrate I;
2) mixing 50g hirudin and 150g Aloe extract, stirring, sterilizing at 90 deg.C for 10min to inactivate enzyme to obtain mixture I;
3) mixing the filtrate I obtained in the step 1) and the mixture I obtained in the step 2), adding 100g of glycerol, and homogenizing at 85 ℃ by using a vacuum homogenizer to obtain a mixture II;
4) cooling the mixture II to room temperature, adding vitamin E100g and Borneolum Syntheticum 30g under stirring, and making into colloidal ointment.
The use method comprises the following steps: the ointment is applied to the affected part three times a day for 7 days as a treatment course.
According to the application, the prepared fleece-flower root, the honeysuckle extract and the borneol are used for nourishing yin, clearing heat, dispelling wind, removing toxicity and relieving the symptom of skin itch, meanwhile, the hirudin and the aloe extract are added to achieve the effects of promoting skin microcirculation, diminishing inflammation and resisting allergy, and the glycerin and the vitamin E are used for moistening and moisturizing the skin and consolidating the effects, so that relapse is avoided. And the ointment is prepared and directly applied on the surface layer of the skin, so that the absorption is faster, the discomfort is relieved very quickly, and the ointment is deeply favored by patients.
While the invention has been described herein with reference to a number of illustrative embodiments thereof, it should be understood that numerous other modifications and embodiments can be devised by those skilled in the art that will fall within the scope of the disclosure. More particularly, various variations and modifications are possible in the component parts or arrangements within the scope of the disclosure and claims of this application. In addition to variations and modifications in the component parts or arrangements, other uses will also be apparent to those skilled in the art.
Claims (4)
1. A composition for dry and itchy skin characterized by: comprises the following raw materials in parts by weight: 0.2 to 0.5 portion of hirudin, 0.6 to 1.5 portions of aloe extract, 0.1 to 0.3 portion of prepared fleece-flower root, 0.1 to 0.3 portion of honeysuckle, 0.8 to 1 portion of glycerol, 0.6 to 1 portion of vitamin E and 0.1 to 0.3 portion of borneol.
2. Composition for cutaneous pruritus according to claim 1, characterized in that: the weight components are as follows: 0.4 part of hirudin, 1.2 parts of aloe extract, 0.2 part of prepared fleece-flower root, 0.2 part of honeysuckle flower, 0.9 part of glycerol, 0.8 part of vitamin E and 0.2 part of borneol.
3. A skin care ointment for treating dry skin and pruritus is characterized in that: the preparation method comprises the following steps:
1) mixing the prepared polygonum multiflorum and the honeysuckle according to the weight ratio of 1:1, adding 6-10 times of water, decocting for 2 hours, and filtering to obtain filtrate I;
2) uniformly stirring hirudin and aloe extract at a weight ratio of 1:3, sterilizing at 80-90 deg.C for 10min to obtain mixture I;
3) mixing the filtrate I obtained in the step 1) and the mixture I obtained in the step 2), adding glycerol, and homogenizing at 80-90 ℃ by using a vacuum homogenizer to obtain a mixture II;
4) cooling the mixture II to room temperature, adding vitamin E and borneol while stirring, and preparing into colloidal ointment.
4. The skin care ointment for skin dryness and itch according to claim 3, characterized in that: comprises the following raw materials in parts by weight: 0.2 to 0.8 portion of hirudin, 0.5 to 1.5 portions of aloe extract, 0.1 to 0.3 portion of prepared fleece-flower root, 0.1 to 0.3 portion of honeysuckle, 0.8 to 1 portion of glycerol, 0.6 to 1 portion of vitamin E and 0.1 to 0.3 portion of borneol.
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Application publication date: 20200327 |