CN110882366A - 一种治疗类风湿关节炎的中药制剂及其制备方法 - Google Patents
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Abstract
本发明提出了一种治疗类风湿关节炎的中药制剂及其制备方法,是由一定重量的七叶连、接骨木、松节、五加皮、寻骨风、络石藤、千年健、南滕、威灵仙、瓦草煎取药汁浓缩做为制药丸的粘合剂,由一定重量的黄芪、当归、干地黄、延胡索、甜瓜子、石枣、秦艽、天麻、制草乌、白花蛇、蜈蚣、八角枫、砂仁粉碎为细粉做药丸备用。上述中药原料经过筛、除杂、煎煮、浓缩、粉碎等步骤制成药丸。本发明中药能够补气壮阳,搜寒舒筋通络,益气生血化津,消肿排毒,外暖经脉护了卫气,内调脏生了营血,使正气逐渐恢复,有效的提高了机体的抗病能力和驱除病邪能力,提高患者的生存质量。
Description
技术领域
本发明涉及中药,具体涉及一种治疗类风湿关节炎的中药制剂,本发明还涉及该中药制剂的制备方法。
背景技术
类风湿关节炎是一种以侵蚀性关节炎为主要表现的全身性自身免疫疾病。本病的发病机制目前不十分明确。临床表现以最初缓慢隐匿方式发病,开始有数周低热,乏力,数天后,关节肿痛,压痛、胀痛,冷疼。以双手近端,指关节,腕关节常见。其次是足趾、膝、小腿、肘肩关节,多对称、持续性。治疗可缓解,但有停药、感冒受寒、劳累等因素又复发。长期的类风湿关节炎易出现滑膜炎和晨疆、血管翳、骨性强直及畸形。除临床表现外,辅助检查如有轻中度贫血;红细胞沉率升高;C反应蛋白增高;类风湿因子阳性,抗环瓜氨酸阳性;关节腔滑液增多,且滑液内白细胞计数和中性粒细胞明显增多;Ⅹ光平片能发现关节周围软组织肿胀,关节端骨质疏松,软骨破坏而变得狭窄,晚期关节面出现虫凿样破坏性改变、骨性强直和关节半脱位。CT检查能更进一步发现骨质变化,B超检查关节液量化等,对类风湿关节炎的诊疗提供了参考依据。药物治疗目前主要选用非甾类抗炎药、抗风湿药、生物制剂、糖皮质激素药。用这些药物治疗类风湿关节炎有减轻疼痛,缓解症状的作用。但仍存在一些问题,如抗炎抗风湿药,除芬必得对肠胃刺激较轻外,其它的抗炎抗风湿药均有明显肠胃反应,占一部分类风湿关节炎患者既没有得到满意的冶疗,又出现明显付作用。又如用皮质激素小剂量的辅助治疗和大剂量激素冲击疗法治类风湿关节炎,能改善症状,减轻疼痛。但付作用更明显,如出现血压升高、虚肿肥胖、心脏受损、继发糖尿病、骨质疏松、肝肾损害、肠胃反应、电解质紊乱、抗病能力下降等。
类风湿关节炎的症状与中医古籍中所描述的“历节风”、“白虎历节”、“痹症”相似。历代医家对痹症(类风湿关节炎)从未停止研究和探索,积累了文献和宝贵临床经验。严用之《济生方》描述“白虎历节,由体虚之人,将理失宜,受风寒湿毒之气,使筋脉凝滞,气血不流蕴于骨节之间或在四肢,肉色不变。其病昼轻夜重,其痛彻骨如虎啮,故名白虎也”。可见类风湿关节炎是由正气亏虚,又受风、寒、湿、热等外邪侵入机体,闭阻经络,气血运行不畅,致使痰浊血瘀阻滞筋骨关节,关节受到侵蚀,疼痛剧烈,痛如虎咬,昼轻夜重,关节肿大,骨质受损,关节周围肌肉瘀肿或筋脉萎缩,关节变形长期不愈,耗伤元气,形成正虚邪恋,顽固难治之病。辩证以内治为主,配合针灸、按摩、推拿、中药离子导入、中药泡洗、全身药浴、薰蒸、患处膏贴、穴贴等等,对类风湿关节炎的治疗起到了一定的作用。但疗程长,治痛作用慢,临床效果不显著。在类风湿关节炎患者在已出现晨僵、剧烈疼痛、骨关节滑膜炎、血管翳、关节畸形的情况下,经过阶段性治疗也收效甚微。
发明内容
本发明人从事中医临床工作已40多年,在治疗常见病过程中,重视类风湿关节炎研究的和治疗。发现有些中药有类似的激素作用和强精壮骨,减轻骨质疏松、减轻骨滑膜炎的作用,配伍补阳益阴、强肾壮骨、活血养血、化瘀生新的中药,治疗类风湿关节炎有止痛,消肿,减少关节积液,保护和修复骨关节膜的作用,还有阻止和延缓血管翳的发生发展作用。为了进一步提高治疗类风湿关节炎的临床效果,查阅有关类风湿关节炎诊疗资料和医学文献,拓宽思路,辨证分析类风湿关节炎的发病由先天不足,肾气不充,精髓衰少,正气亏损,风寒湿邪又乘虚而入,由表及里,由浅入深,先侵经络,渐袭筋脉,后犯关节,肢节肿胀疼痛。邪恋日久,导致机体阴阳俱损,气血双亏,甚则邪入脏腑,呕吐不食,烦乱失眠,悸动不安。本发明人反复研究,治疗从补元固精,滋养肝肾,强筋壮骨,散瘀排毒,通络止痛入手,结合自已临床发现和治疗经验,在临床实践中,以类风湿关节炎患者病势进退和辅助检查结果,做为治疗效果的标准,从治疗类风湿关节炎效果好的中药中反复筛选,到用中药剂量的反复增减,不断探索研究,总结分析,多次改新,经临床实践验证,提高了治疗类风湿关节炎的临床效果。
本发明人通过不懈努力,终于找到并研制出疗效突出的治疗类风湿关节炎的中药制剂,完成了本发明。至今,还没有发现有关本发明的报道。本发明的目的是提供一种治疗类风湿关节炎的中药制剂,用本发明的中药制剂按说明口服,主要治疗类风湿关节炎症见肢体关节疼痛,时发时止,屈伸不利,关节拘急,得冷痛甚,畏寒喜暖,腰膝软弱无力,局部肿胀或僵硬变形,舌胖,质淡苔白腻,脉沉细弱或细涩,属寒湿痰瘀,气血亏损,肝肾不足的复合证候。患者服本品,通过补气壮阳,搜寒舒筋通络,益气生血化津,消肿排毒,外暖经脉护了卫气,内调脏生了营血,使正气逐渐恢复,有效的提高了机体的抗病能力和驱除病邪能力。血气足则气行血行,阳气盛则寒邪自退,瘀滞消散则肿减显著痛轻,僵硬强直的筋骨才得以舒展,从而使之类风湿关节炎患者从根本上好转。
本发明的另一目的是提供该制剂的制备方法。
本发明所采取的技术方案是:一种治疗类风湿关节炎的中药制剂,由以下重量的原料药物组成:
以下中药煎取药汁浓缩做为制药丸的粘合剂:
七叶连200~800克,接骨木75~300克,松节75~300克,五加皮75~300克,寻骨风75~300克,络石藤50~200克,千年健50~200克,南滕50~200克,威灵仙50~200克,瓦草50~200克;
以下中药粉碎为细粉做药丸备用:
黄芪300~1200克,当归150~600克,干地黄300~1200克,延胡索150~600克,甜瓜子150~600克,石枣100~400克,秦艽100~400克,天麻100~400克,制草乌45~180克,白花蛇50~200克,蜈蚣50~200克,八角枫30~120克,砂仁50~200克。
本发明制剂的七叶莲:祛风除湿,活血止痛。治风湿痹痛,《广西实用中草药新选》“行气止痛,活血消肿,壮筋骨,治急性风湿性关节炎”。据《中药大辞典》临床报导中:七叶莲对于各种类型的疼痛,风湿痛,神经痛,各种癌肿及手术后疼痛等,均有一定的镇痛效果。本发明人在临床使用七叶连时发现,该味中药用水煎服用量在30克以上才能显示止痛效果,配伍恰当效果更好,也没发现付作用及过敏反应。接骨木:治风湿筋骨疼痛,腰痛。《现代实用中药》:“为镇痛药,治手足偏风及风湿腰痛,骨间诸痛,四肢寒痛,脚肿。”松节:《千斤方》:治历节风,四肢疼痛犹如解落。”《本草汇言》:“有风有湿,作痛作酸,痿软无力者,用此立痊。”《中药大辞典》五加皮:祛风湿,壮筋骨,活血祛瘀。治风寒湿痺,筋骨挛急。据《中药大辞典》药理:“五加皮有镇痛和抗炎作用,能增强机体对有害刺激因素的抵抗力,对长期服抗炎、镇痛、激素类药物有抗药性的类风湿关节炎患者,改用中药五加皮治疗仍能迏到治痛效果”。寻骨风:《饮片新参》:散风痹,通络,治骨节痛。临床报道:寻骨风有治风湿,类风湿关节炎的作用,观察治疗1一3个月,关节肿胀改善,部分强硬的关节活动度增大。络石藤:治风湿痹痛筋脉拘挛。《要药分剂》:“络石之功,专于舒筋活络。凡病人筋脉拘挛,不易伸屈者,服之无不获效,不可忽之也。”《本草正义》:“今用以舒筋活络,宣通痹痛甚验。”千年健:《中药大辞典》:“祛风湿,壮筋骨,止痛,消肿。治风湿痹痛,肢节酸痛,筋骨痿软。”《本草正义》:“千年健,今恒用之于宣通经络,祛风逐痹,颇有效验。”南滕:《中药大辞典》“治心力衰竭,劳力腰痛,跌打损伤。祛风湿,通经络,强腰膝,止痛。治风寒湿痹,筋骨疼痛,腰痛,术后疼痛。”《中药大辞典》临床报道:“用于治痛,对于手术后疼痛骨折修复及胃肠肝胆部疼痛,慢性腰腿痛,关节炎等均有镇痛效果,部分病人用药后有催眠、镇静作用。”威灵仙:《药品化义》:“性猛急,善走而不守,宣通十二经络,主治风、湿、痰、壅滞经络中,致成痛风走注,骨节疼痛,或肿,或麻木。”瓦草:《中药大辞典》“清热止痛,治风湿骨痛。”《中药大辞典》临床报道:“临床用于各种疼痛32例,一般15分钟开心始痛减,半小时痛止。维持时间最短5小时,长迏20小时”。黄芪:《本草正》:黄耆(黄芪)补元阳,充腠理,治劳伤,长肌肉,气虚难汗者可发,表疏多汗者可止。药理研究并通过临床证明,黄芪有明显的补气强心,加强心肌收缩力,扩张冠状动脉血管,利尿消肿,减少尿蛋白,护肝保肾,降低血压和血糖,利水排毒和敛津止汗,强壮肌力体力、增强耐受力的作用,当归:《本草正》“补中有动,行中有补,利筋骨,治拘挛,瘫痪、燥涩等症。”(《圣惠方》当归散)治白虎风,疼痛不止;干地黄:《本径》“主折跌绝筋,伤中,遂血痹,填骨髓,长肌肉。”《中药大辞典》临床报道口服干地黄水煎服治类风湿关节炎,能使关节疼痛减轻,关节肿胀消退,肢体活动障碍好转。据观察干地黄具有抗炎作用和类似激素样作用。延胡索:活血散瘀,理气止痛。《纲目》:“延胡索,能行血中气滞,气中血滞,专治一身上下诸痛,用之中的,妙不可言。”甜瓜子:能散结消瘀,润肠清肺。《寿域神方》:“治腰腿疼痛。”民间用甜瓜子炒焦磨粉约15克冲服,一日两次,少则半月,多则月余,治疗骨折,末经医家正骨用药,而很快全愈,屡见奇效。本人曾多次运用甜瓜子治疗跌打损伤,骨折的患者,发现能缩短疗程。通过X光拍片显示,骨痂形成较其它疗法提前15一30天,骨折线消失。并发现甜瓜子能自主找茬正骨,有活血化瘀,通络止痛作用。甜瓜子还有营养骨骼筋脉,保护关节,填充骨髓,补充钙质,增加骨密度的作用。石枣:“祛风除湿,消肿止痛。治高热惊风,风湿痹痛,四肢麻木关节肿痛。”秦艽:《中药大辞典》:“治风湿痹痛,筋骨拘挛,骨蒸潮热。”【临床报道】“治疗关节痛,头痛,牙痛等。对风寒引起的周身疼痛,以及多年风湿性腿痛均有止痛效果。有抗炎和减轻关节肿胀程度并加速消退作用,有一定镇痛作用,与延胡索、草乌等并用可使作用增强。”天麻,性甘平,《日华子本草》:“助阳气,补五劳七伤,通血脉,开窍。”《开宝本草》:“主诸风湿痹,四肢拘挛,...利腰膝,强筋力。”草乌《中药大辞典》:苦辛大热大毒,搜风胜湿,散寒止痛开痰消肿治风寒湿痹。《药性论》:“乌喙,其气锋锐,通经络,利关节,寻溪达径直抵病所。”白花蛇:《中药大辞典》:“祛风湿,透筋骨。治风湿瘫痪,骨节疼痛。”《本草径疏》:“蛇性走窜,亦善行而无处不到,故能引诸风药至病所,自脏腑而迏皮毛也。”蜈蚣:“祛风,定惊,攻毒,散结,通络止痛”。《医学衷中参西录》:“蜈蚣,走窜之力最速,内而脏腑,外而经络,凡气血凝聚之处皆能开之。”蜈蚣的临床应用越来越广泛,临床研究越来越深入。本发明人在用蜈蚣治疗类风湿关节炎的实践中发现除有搜寒熄风,解痉止痛的作用外,在止痛消肿,保护骨膜,清除软组织毒素,减少关节腔内积液方面用有明显的临床效果。八角枫:《纲目拾遗》“性热,力猛,有毒。”《中药大辞典》:“辛温,有毒。祛风,通络,散瘀,镇痛,有麻醉及松弛机肉的作用。治风湿疼痛,麻木瘫痪 。砂仁:和胃,醒脾。《本草汇言》:“砂仁,通畅三焦,温行六腑,暖肺醒脾,养胃养肾,舒迏肝胆不顺不平之气。”
本发明配伍的中药,以黄芪扶正气,调营卫,充腠理,当归生血活血,气行血行,养脏腑,利筋骨。携干地黄益气生津、填髓、逐痹。配甜瓜子散结消瘀。用于扶正气,养津血,濡脏腑、壮骨节为君;以大热之草乌祛寒止痛,配走窜最速之蜈蚣、白花蛇、寻骨风透骨搜风止痛,配玄胡索、接骨木理气化瘀止痛,五加皮、七叶莲、南藤通络止痛为臣;又佐以宣通十二经的威灵仙,通痹通络的络石藤,松驰肌肉,解除挛缩的八角枫,舒筋止痛的松节,清热止痛的瓦草,退热止痛的石枣,除骨蒸止痛的秦艽,和强筋力,壮筋骨,除湿痹,治肢体麻木,筋脉拘急的天麻、千年健;使以醒脾和胃、增加食欲的砂仁。以上君臣诸药,相须相使,达到补气固表,解除骨关节挛缩,固肾强筋壮骨,祛寒散热排毒,活血化瘀,消肿止痛的作用、恢复肢体关节功能之目的。
本发明治疗类风湿关节炎的中药制剂的制备方法是:所选中药过筛,拣去杂质,并做炮制:
. 所用的草乌,按草乌10份,黑豆1份,甘草0.5份之比例置煮锅内加净水煎煮,以淹没草乌为度,水沸后煎煮2小时~3小时以上,每30分钟将制的草乌上下翻勻,充分煮透,出锅前,切开制的草乌,检查无白心干心为宜,然后晒干,拣去杂质,挑肥大肉厚的备用;
. 将筛选的七叶莲、接骨木、松节、五加皮、寻骨风、络石藤、千年健、威灵仙、南藤、瓦草,按上述重量称准,然后放置在煮药锅内,加纯净水5000毫升,以按之淹没中药上面仍有3厘米水为度,以沸计时煎30分钟,滤汁于洁净器容器;再往留有中药楂需要二次水煎的煮锅内加纯净水3500毫升,沸30分钟后滤出药汁与第一次滤出的药汁兑在一起;然后将煮药锅内药楂倒出不用,净水冲洗干净煮药锅,把前面的两次煎煮的药汁倒入煮药锅内,煮沸浓缩,浓缩时间120分钟~150分钟,在浓缩时勤观察,浓缩至600毫升备用;再将黄芪、当归、制干地黄、甜瓜子、草乌、延胡索、石枣、秦艽、天麻、蜈蚣、白花蛇、八角枫、砂仁按上述配比的重量称准,然后用粉碎机粉碎至细粉,过100目筛,掺匀备用;
.把上述煎出浓缩备用的药液掺到粉碎的细药粉内,充分搅拌,湿度为:握之成团,搓之即撒,拌成潮湿适当的粿粒状;然后用制药丸机将拌成的做药丸的原料揉挤成块状,经出药口挤压制出如红豆大小的药丸;把烤箱温度设置50~60°C,再将制出湿度较大的药丸放入烤箱,慢火烤干时放凉,然后用药丸抛光机抛光;烤箱烤药丸时温度不宜过高,防止烤枯碳化,不易溶解,影响收消化,降低药效。
本发明性状:本发明的口服中药制剂系纯中药浓缩水丸,不含防腐剂和激素,没添加任何化学止痛成份,色泽乌黑明亮,草药香味浓郁,无异臭。
使用方法:本发明的中药制剂属口服中成药,治疗类风湿关节炎患者,需经临床医师辨证属寒湿痰瘀,气血亏损,肝肾不足的复合证候,才可按剂量服用本品,每服9克,分早晚日服两次,饭后服。确需加量,必经临床医师许可后依次逐渐加量服用。
临床功效:主要功能在于:外暖经脉护卫气,内调脏腑生营血。服用本品能补气壮阳,生血化津,活血行血,化瘀消滞,搜风剔除寒邪,除湿消肿,散热排毒;使类风湿关节肿痛消失或明显减轻,病变的关节功能逐渐恢复,使症状从根本上好转。
主临床治:主要治疗类风湿关节炎症见肢体关节疼痛,时发时止,屈伸不利,关节拘急,畏寒喜暖,得冷痛增,得暖疼减,心悸怔肿,气怯出汗,食少便溏,腰膝软弱无力,关节疼痛,局部肿胀或僵硬变形,舌胖,质淡苔白腻,脉沉细弱或细涩,属寒湿痰瘀,气血亏损,肝肾不足的复合证候。
禁忌:(1)、凡类风湿关节炎,症见大小关节热胀肿痛,发热汗出,囗干舌噪,大便秘结,舌红苔白或黄或干的热痹,郁火阳亢证而患有类风湿关节炎者禁用;(2)、凡症见骨蒸劳热,肢体关节疼痛,梦遗盗汗,干渴缺津,舌红无苔,脉细或虚,阴虚津亏,筋脉失养证而患有类风湿关节炎者禁用;(3)、严禁类风湿关节炎患者自主加服次数、量数。
注意事项:服药期间忌食辛燥油腻、生冷食物。
规格:9克/袋装、 20袋/盒装、30袋/盒装。
贮存:于阴凉通风干燥处。
有效期:三年。
本发明中药制剂能恢复正气,提高机体抗病能力,纠正阴阳偏盛偏衰, 营卫调和,腠理通畅。将已侵入机体的外邪排出到体外。通过本品的益气壮阳,濡养肝肾筋骨,增强气化作用和调整机体内分泌作用,促进机体的新陈代谢,有利机体排出病邪毒素。本发明人研制的治类风湿关节炎中药制剂,扶正祛邪并施,配伍了强劲的搜寒通络,化瘀消积,松解挛缩,滋养筋骨,消肿止痛的中药,口服该中药制剂后,能使关节肿胀消退,关节冷痛、沉痛、酸痛、麻痛明显减轻,强硬逐渐松解,晨僵现象减轻并逐渐消失。畸形轻微的关节开始活顺,活动幅度加大。病理化验可见类风湿因子随病情好转而逐渐消失,X光拍片提示所患关节炎处积液减少,炎症减轻,骨密度增加。患者饮食加增,能从事一般劳动,生活质量明显提高。
用该发明的中药制剂,治疗类风湿关节炎病程约在3个月~1年的早期患者,检查受累关节有肿痛及活动受限,X线显示软组织肿胀及骨质疏松。口服15天~30天后,指关节、腕关节、足趾关节疼痛明显减轻,肿胀开始消退,尤其是凉痛,胀痛减轻最为明显,四肢畏寒怕冷周身困痛等症状缓解,口服该药30天~2个月后,关节疼痛进一步减轻或消失,关节肿胀明显好转,患者感到全身轻松,困倦乏力及怕冷现象亦随之消失。服用本品3个月~5个月后关节肿胀消退,痛冷痛压痛逐渐消失。坚持服用6个月后,抵抗力增强,关节活动功能恢复正常。检查:X线片显示关节周围的肌肉、韧带及结缔组织肿胀消失,查验血液:类风湿因子转阴。早期类风湿关节炎患者,经本发明制剂按疗程坚持治疗,基本治愈或明显好转。类风湿关节炎在中期的,病程一般在2~4年以上,部分受累关节功能活动明显受限,X线片显示关节间隙变窄,并有不同程度骨质侵蚀。服用本制剂药丸,10至15天,疼痛开始减轻,肿胀的指关节、腕关节处有消肿迹象。口服该药,1个月后,疼痛减轻,肿胀关节开始消退,上肢和下肢的冷痛也有明显好转。服3~6个月后,检查发现,明显减轻或疼痛消失,晨僵时间缩短或消失,受累关节强直现象明显改善,服6~9个月后,僵硬关节有所松动,腕关节、手指关节、踝关节活动角度幅度变大,检查:X线片显示关节间隙增大,受累的关节运动功能逐渐恢复,配合锻炼,能够参与力所能及的活动。类风湿关节炎受累的关节若表现骨性强直及畸形,活动困难,X线片显示关节出现血管翳、关节面出现损伤侵蚀、脱位或融合,提示类风湿关节炎患者的病程大多在6~8年以上,已到晚期的严重阶段,但亦有个别类风湿关节炎患者,从早期发现很快进入晚期的严重阶段。按说明服用本发明制剂15天~1个月后,患者感到疼痛明显减轻,患者翻身,挪动肢体时,减少了痛苦。坚持服用本发明制剂,患者的精气衰虚,困绻无力,气虚自汗,脾虚食少均能改善,能明显提高患者的生存质量。
具体实施方式
本发明药物的组织成份、用量是发明人经过长期临床实践、不断探索、分析研究、结合自已经验得来的,各组的分量是在下述重量配伍、配比范围内,才能发挥最佳疗效。
七叶连200~800克,接骨木75~300克,松节75~300克,五加皮75~300克,寻骨风75~300克,络石藤50~200克,千年健50~200克,南滕50~200克,威灵仙50~200克,瓦草50~200克(以上中药煎取药汁浓缩做为制药丸的粘合剂);
黄芪300~1200克,当归150~600克,干地黄300~1200克,延胡索150~600克,甜瓜子150~600克,石枣100~400克,秦艽100~400克,天麻100~400克,制草乌45~180克,白花蛇50~200克,蜈蚣50~200克,八角枫30~120克,砂仁50~200克(以上中药粉碎为细粉做药丸备用)。
实施例1
本发明一种治疗类风湿关节炎的中药制剂,由以下重量的原料药物组成:
七叶连200克,接骨木75克,松节75克,五加皮75克,寻骨风75克,络石藤50克,千年健50克,南滕50克,威灵仙50克,瓦草50克,(以上中药煎取药汁浓缩做为制药丸的粘合剂);
黄芪300克,当归150克,干地黄300克,延胡索150克,甜瓜子150克,石枣100克,秦艽100克,天麻100克,制草乌45克,白花蛇50克,蜈蚣50克,八角枫30克,砂仁50克(以上中药粉碎为细粉做药丸备用)。
该中药制剂的制备方法为:所选中药过筛,拣去杂质,并做炮制,具体做法是:(1)、当归用全当归;天麻挑个大干透,掰开坚实岔子质硬,色泽黄白明亮半透明者;干地黄用烤箱烤至干透,目的是利于彻底粉碎,防止粘腻粘罗,并能防止生湿伤脾。(2)、威灵仙、五加皮、寻骨风、络石藤、千年健、瓦草、均用黄酒按比例10:2,即药10酒2拌匀置笼上蒸,看笼上气滿后蒸30分钟,然后摊通风处阴干备用。(3)、八角枫选用粗根切薄片,丸剂口服每日量控制在0.5克以下安全有效。(4)、用的草乌,按草乌10份,黑豆1份,甘草0.5份之比例置煮锅内加净水煎煮,以淹没草乌为度,看水沸后煎煮2小时~3小时以上,每30分钟将制的草乌上下翻勻,充分煮透,出锅前,切开制的草乌,检查无白心干心为宜,然后晒干,拣去杂质,挑肥大肉厚的备用。(5)、然后将筛选的七叶莲、接骨木、松节、五加皮、寻骨风、络石藤、千年健、南藤、威灵仙、瓦草按上述重量称准,然后放置在煮药锅内,加纯净水5000毫升,以按之淹没中药上面仍有3厘米水为度,以沸计时煎30分钟,滤汁于洁净器容器,再往留有中药楂需要二次水煎的煮锅内加纯净水3500毫升,沸30分钟后滤出药汁与第一次滤出的药汁兑在一起。然后将煮药锅内药楂倒出不用,净水冲洗干净煮药锅,把前面的两次煎煮的药汁倒入煮药锅内,煮沸浓缩。浓缩时间约120分钟~150分钟,这段时间勤观察,煮沸浓缩至600毫升左右备用。再将黄芪、当归、制干地黄、延胡索、甜瓜子、石枣、秦艽、天麻、制草乌、白花蛇、蜈蚣、八角枫、砂仁按上述配比的重量称准,然后用药用粉碎机粉碎至细粉,过100目筛,去粗未杂质,掺匀备用。(6)、把上述煎出浓缩备用的药液掺到粉碎的细药粉内,充分搅拌,湿度为:握之成团,搓之即撒,拌成潮湿适当的粿粒状。然后用制药丸机将拌成的做药丸的原料揉挤成块状,经出药口挤压制出如红豆大小的药丸。再把药用烤箱温度设置05°~60°C,再将制出湿度较大的药丸放入烤箱,慢火烤干时放凉,然后用药丸抛光机抛光。烤箱烤药丸时温度不宜过高,防止烤枯碳化,不易溶解,影响收消化,降低药效。
实施例2
本发明一种治疗类风湿关节炎的中药制剂,由以下重量的原料药物组成:
七叶连400克,接骨木150克,松节150克,五加皮150克,寻骨风150克,络石藤100克,千年健100克,南滕100克,威灵仙100克,瓦草100克 (以上中药煎取药汁浓缩做为制药丸的粘合剂);
黄芪600克,当归300克,干地黄600克,延胡索300克,甜瓜子300克,石枣200克,秦艽200克,天麻200克,制草乌90克,白花蛇100克,蜈蚣100克,八角枫60克,砂仁100克 (以上中药粉碎为细粉做药丸备用)。
该中药制剂的制备方法为同实施例1。
实施例3
本发明一种治疗类风湿关节炎的中药制剂,由以下重量的原料药物组成:
七叶连800克,接骨木300克,松节300克,五加皮300克,寻骨风300克,络石藤200克,千年健200克,南滕200克,威灵仙200克,瓦草200克(以上中药煎取药汁浓缩做为制药丸的粘合剂);
黄芪1200克,当归600克,干地黄1200克,延胡索600克,甜瓜子600克,石枣400克,秦艽400克,天麻400克,制草乌180克,白花蛇200克,蜈蚣200克,八角枫120克,砂仁200克(以上中药粉碎为细粉做药丸备用)。
该中药制剂的制备方法为同实施例1。
临床应用:
类风湿关节炎诊断依据和诊断标
诊断依据:1.晨僵≥1h(小时)。2.关节炎≥3个关节区。3.手关节(腕关节、掌指关节、近侧指间关节)受累。4.对称关节受累。5.累风湿关节结节。6.类风湿因子存在,采用的检查方法在正常人阳性率<5%。7.Ⅹ线手部照片骨质侵蚀或肯定的骨质脱钙。
诊断标准(1)症状:以小关节为主,多为多发性关节肿痛或小关节对称性肿痛(单发者须认真与其他鉴别,关节症状至少持续6周以上),晨僵。(2)体征:受累关节肿胀压痛,活动功能受限,或畸形,或强直,部分病例可有皮下结节。(3)实验室检查:RF(类风湿因子)阳性,ESR(血沉)多增快。(4)X线检查:重点受累关节具有典型类风湿性关节炎X线所见。对具备上述症状及体征的患者,或兼有RF阳性,或兼有典型X线表现者均可诊断。并有如下分期:早期:绝大多数受累关节有肿痛及活动受限,但X线仅显示软组织肿胀及骨质疏松。中期:部分受累关节功能活动明显受限,X线片显示关节间隙变窄及不同程度骨质腐蚀。晚期:多数受累关节出现各种畸形或强直,活动困难,X线片显示关节严重破坏、脱位或融合。
疗效判定标准:
类风湿关节炎治愈标准:临床症状活动功能恢复、实验室检查结果全部恢复正常。
类风湿关节炎好转标准:关节疼痛减轻,功能基本恢复,血沉正常或偏高,类风湿因子转阴。
类风湿关节炎无效标准:临床症状无改善,关节疼痛存在甚至加重,功能基本没有恢复,血沉加快或仍偏高,类风湿因子阳性。
临床应用:
临床上收治明确诊断的类风湿患者55名,男性患者16人,女性患者39人,年令范围在23~67岁平均为45岁,治疗周期3~12个月,其中用本发明中药制剂治疗的是28人,用西药治疗的是27人,选择治疗的药物: 中药治疗组用本发明制剂水丸,按制剂水丸9克/袋,每人每日2次,分早晚饭后服,每次服9克/袋。疼痛难忍,夜不能眠的患者,夜12点左右加服一袋/9克,疗程分别是3~9个月。西药治疗组选用有消炎止痛作用的布洛芬胶囊口服0.3~0.6ɡ每日2次,患者有恶心呕吐,腹泻或头痛眩晕等反应,改用芬必得每日按常规量口服,必要时加维生素B6,胃友口服。抗风湿药选用甲氨蝶呤每次5~20mg,每周1次。糖皮质激素选用中等剂量的泼尼松30~40mg/d,待症状控制后逐步减少至最小维持量。治疗过程中定时做了检查验血,防止和治疗了并发症。
依照类风湿关节炎诊断依据诊断标准和疗效判定标准,按程度分期,疗效分析如下:
(1)从临床观察和治疗结果可以看出,类风湿关节炎早确诊,早治疗最为关键,无论中医药物和西医药物对类风湿性关节炎的早期治疗都有明显好转,尤其中医辨证论治,选药配伍精准,患者按医嘱,耐心坚持用药,占一部分是可以治愈的。对类风湿性关节炎中期晚期的患者也有好转的作用。
(2)临床实践证明,本发明制剂的益气补血,滋养肝肾,强筋壮骨,捍卫阳气,提高机体抗病能力的作用,对类风湿关节炎晚期患者的疼痛缓解、关节强直的松解、骨质疏松和骨骼肌痿缩的改善、提高患者的生存质量,已显示出一定作用。从服本中药制剂治疗类风湿关节炎,与西药治疗类风湿关节炎相比,中药治 28人,早期治14人,全愈3人 , 好转11人,中期8人 ,好转8人, 后期6人,好转4人,无效2人。西药治27人,早期治15人,好转15人,中期7人,好转6人,无效1人,后期5人,好转1人,无效4人。
(3)针对类风湿关节炎如上表显示:本发明制剂的治疗组与西药的治疗组相比,本发明制剂的治愈率,好转率高于西药的临床效果。
(4)临床实践证明,类风湿关节炎属慢性,顽固难治疾病,纯用西药治痛或简单的活血止痛,仅有一时之效,唯有辩证论治,固本为先,扶正祛邪,补益肝肾,生精养髓,调养筋骨,徐缓图之,才能渐渐好转,否则欲速而不迏。只要辩证准确,配伍恰当,鼓励患者树立信心,坚持治疗,即使是晚期类风湿关节炎,也能治明显好转的临床效果。
典型病例:
病例1:陈某某,女,53岁,住方城县杨楼乡舒庄村。2015年6月经别人介绍到我所就诊,患者四肢怕冷怕风,手腕及指关节、膝关节、趾关节肿胀疼痛,触按痛甚,阴雨天或入夜痛剧已一年,常以西药布络芬和强地松等药控制疼痛。自汗,易感冒,喜热饮,大便稀簿,舌淡苔薄少而湿润,脉沉缓无力。近期查血沉快,类风湿因子阳性,取本发明的治类风湿关节炎的中成药2个月,每次一包,日服两次,饭后服,并嘱咐避风寒、饮食忌生冷、油腻食品。2015年9月,患者到诊所第一句话就是“见效了”,患者并说痛也轻了,西药止痛药也停了,想取再点中成药,据病情和患者要求,患者取本发明治类风湿关节炎的中成药3个月,并按医嘱服用。后又取该药多次,2018年12月复诊,患者查类风湿因子阴性,关节疼痛消失,功能活动正常,类风湿病未复发,康复全愈并从事正常的体力劳动。
病例2:王某某,女,方城县城关镇人。2015年冬天,因外出受寒,四肢末梢冷痛,两个月后渐肿胀痛的,随后腰疼膝关节疼痛。在本县住院治疗两个月。症状未见好转并逐渐加重,手指食指,中指,无名指关节肿胀凉痛,足趾关节肿痛,经县人民医院验血查出:血沉90mm/小时,类风湿因子阳性。2016年8月患者有家属搀扶到我诊治。证见脚手怕冷,手指关节脚趾关节肿胀痛甚,有时疼的哭叫难忍,舌淡湿润,脉沉缓无力,属气虚寒凝,气血瘀阻不通。用本发明治类风湿关节炎的中成药,每日2次,每次服1包,每包装9克,饭后口服,同年10月,患者自行来诊,自述服药过程:“服您的药丸,七八天仍没见效,真是失去信心了,是家属鼓励坚服用,服用15天后才见疼痛减轻,20天后,脚手不那么凉了,痛也轻了,肿也轻了”,患者又取该治类风湿关节炎的中成药三个月。2017年3月,患者到诊所复诊,趾关节和手指关节肿胀疼痛消失,晨僵不再出现,化验血类风湿因子阴性。又取该发明治类风湿关节炎5个月的中成药,以巩固疗效。2018年春节见到曾患类风湿的陈某,问及近况,大小关节,没再疼痛,功能活动恢复正常,化验类风湿因子阴性,现已上班工作,类风湿关节炎全愈。
病例3:张某某,女40岁,方城县一宾馆职工。2008年九月,因患类风湿关节炎到我诊所就诊。临床表现:手指关节凉,肿胀不能握拳,怕冷怕风,气怯心慌,自汗后身冷,食欲不振,夜不能眠,脉沉缓,舌淡苔湿润。诊为气虚寒凝,瘀阻经络。取该发明制剂1个月量,日服2次,每次1包9克,分早晚,饭后服。1个月后,患者复诊,患者手指肿痛稍轻,夜已能眠,唯仍气虚饮食无味,取该制丸药2个月,嘱咐配人参健脾丸按说明同服。2009年1月,患者三次来诊,手指关节肿胀已消,手能握拳,疼痛明显减轻。自述“轻多了,能吃能睡”。又取该丸药3个月,继续治疗。同年7月,患者张某某又到我所,复诊,手指关节肿胀,疼痛消失,肢体亦不怕冷了,参加正常的工作芽动。化验血查类风湿因子转阴性,舌淡红,苔白脉平,又取该制剂2个月巩固疗效,并嘱忌气恼,避风寒,少食生冷或燥热食品。
病例4:郭某某,男,43,河南方城券桥乡人。2007年因交通事故撞伤左蹆,在南阳某医院治疗3个月后,左侧大蹆肌肉痿缩,继而四肢关节疼,一年后又引起腰痛,髋关节痛,经多家医院化验,血沉加快。抗“O”偏高,类风湿因子阳性。2008年5月,来我诊所治疗。检查:双手腕关节、指关节、足踝关节瘀肿疼痛,手不能握拳,肩背腰膝关节疼痛,动则气怯,悸动不安,夜不能卧,少食即胀,小便溲,大便溏簿,手指关节僵硬畸形,早晨僵硬更甚,待按摩搓揉,热水浸泡后僵硬稍缓。患者得冷痛甚,畏寒喜暖,气怯心慌心跳,面白无华,舌淡苔,湿润,脉沉无力。证属气亏阳虚寒邪瘀阻,治宜补气壮阳,搜寒止痛。让患者服该发明中药制剂,嘱其1日2次,仍分早晚饭后服,每次(9克) 1包,夜12点时加服1包。2008年6月17日,患者自述全身骨关节疼痛减轻,在家人搀扶下能行走活动,但行走时,膝关节和脚趾酸疼,饮食大增,夜能睡眠时间约5小时。检查:手指关节肿胀疼痛明显减轻,握拳疼痛明显,仍有晨僵,气怯心悸舌淡红,苔白润,脉沉滑,取该治类风湿的中药制剂3个月,服用时间改为1日3包,每次(1包/9克)1包,饭后服。2009年2月,患者复诊,四肢关节,尤其是脚趾关节和手指关节肿痛明显减轻,手腕关节及手指关节活动幅度及角度增大,手腕关节及手指关节畸形有所好转,到县医院化验抗“o”转阴性,血沉正常,但仍查出有风湿因子。又取该治类风湿关节炎的中成药丸3个月的量,巩固治疗。2010年4月,电话随访,患者说,“现在全身关节痛已明显轻了,不是阴天下雨基本不疼了”。嘱其忌生冷,别劳累,避风寒,坚持治疗争取进一步好转。
Claims (5)
1.一种治疗类风湿关节炎的中药制剂,其特征是由以下重量的原料药物组成:
以下中药煎取药汁浓缩做为制药丸的粘合剂:
七叶连200~800克,接骨木75~300克,松节75~300克,五加皮75~300克,寻骨风75~300克,络石藤50~200克,千年健50~200克,南滕50~200克,威灵仙50~200克,瓦草50~200克;
以下中药粉碎为细粉做药丸备用:
黄芪300~1200克,当归150~600克,干地黄300~1200克,延胡索150~600克,甜瓜子150~600克,石枣100~400克,秦艽100~400克,天麻100~400克,制草乌45~180克,白花蛇50~200克,蜈蚣50~200克,八角枫30~120克,砂仁50~200克。
2.根据权利要求1所述的一种治疗类风湿关节炎的中药制剂,其特征是由以下重量的原料药物组成:
以下中药煎取药汁浓缩做为制药丸的粘合剂:
七叶连200克,接骨木75克,松节75克,五加皮75克,寻骨风75克,络石藤50克,千年健50克,南滕50克,威灵仙50克,瓦草50克;
以下中药粉碎为细粉做药丸备用:
黄芪300克,当归150克,干地黄300克,延胡索150克,甜瓜子150克,石枣100克,秦艽100克,天麻100克,制草乌45克,白花蛇50克,蜈蚣50克,八角枫30克,砂仁50克。
3.根据权利要求1所述的一种治疗类风湿关节炎的中药制剂,其特征是由以下重量的原料药物组成:
以下中药煎取药汁浓缩做为制药丸的粘合剂:
七叶连400克,接骨木150克,松节150克,五加皮150克,寻骨风150克,络石藤100克,千年健100克,南滕100克,威灵仙100克,瓦草100克;
以下中药粉碎为细粉做药丸备用:
黄芪600克,当归300克,干地黄600克,延胡索300克,甜瓜子300克,石枣200克,秦艽200克,天麻200克,制草乌90克,白花蛇100克,蜈蚣100克,八角枫60克,砂仁100克。
4.根据权利要求1所述的一种治疗类风湿关节炎的中药制剂,其特征是由以下重量的原料药物组成:
以下中药煎取药汁浓缩做为制药丸的粘合剂:
七叶连800克,接骨木300克,松节300克,五加皮300克,寻骨风300克,络石藤200克,千年健200克,南滕200克,威灵仙200克,瓦草200克;
以下中药粉碎为细粉做药丸备用:
黄芪1200克,当归600克,干地黄1200克,延胡索600克,甜瓜子600克,石枣400克,秦艽400克,天麻400克,制草乌180克,白花蛇200克,蜈蚣200克,八角枫120克,砂仁200克。
5.制备权利要求1-4任一所述一种治疗类风湿关节炎的中药制剂的方法,其特征是所选中药过筛,拣去杂质,并做炮制:
. 所用的草乌,按草乌10份,黑豆1份,甘草0.5份之比例置煮锅内加净水煎煮,以淹没草乌为度,水沸后煎煮2小时~3小时以上,每30分钟将制的草乌上下翻勻,充分煮透,出锅前,切开制的草乌,检查无白心干心为宜,然后晒干,拣去杂质,挑肥大肉厚的备用;
. 将筛选的七叶莲、接骨木、松节、五加皮、寻骨风、络石藤、千年健、威灵仙、南藤、瓦草,按上述重量称准,然后放置在煮药锅内,加纯净水5000毫升,以按之淹没中药上面仍有3厘米水为度,以沸计时煎30分钟,滤汁于洁净器容器;再往留有中药楂需要二次水煎的煮锅内加纯净水3500毫升,沸30分钟后滤出药汁与第一次滤出的药汁兑在一起;然后将煮药锅内药楂倒出不用,净水冲洗干净煮药锅,把前面的两次煎煮的药汁倒入煮药锅内,煮沸浓缩,浓缩时间120分钟~150分钟,在浓缩时勤观察,浓缩至600毫升备用;再将黄芪、当归、制干地黄、甜瓜子、草乌、延胡索、石枣、秦艽、天麻、蜈蚣、白花蛇、八角枫、砂仁按上述配比的重量称准,然后用粉碎机粉碎至细粉,过100目筛,掺匀备用;
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Citations (2)
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CN104352813A (zh) * | 2014-10-30 | 2015-02-18 | 张运鹏 | 一种用于治疗类风湿关节炎及腰椎间盘突出的中药水丸 |
CN109091641A (zh) * | 2017-06-21 | 2018-12-28 | 洛阳士雄聚元医疗集团股份有限公司 | 一种治疗风湿性关节炎的药酒 |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104352813A (zh) * | 2014-10-30 | 2015-02-18 | 张运鹏 | 一种用于治疗类风湿关节炎及腰椎间盘突出的中药水丸 |
CN109091641A (zh) * | 2017-06-21 | 2018-12-28 | 洛阳士雄聚元医疗集团股份有限公司 | 一种治疗风湿性关节炎的药酒 |
Non-Patent Citations (3)
Title |
---|
袁庭芳: "《茶酒祛病强身500方》", 31 January 2007, 河北科学技术出版社 * |
陈骏骐: "《中药药剂学》", 31 August 1989, 山东科学技术出版社 * |
高景华: "《名医珍藏药酒大全》", 30 April 2012, 陕西科学技术出版社 * |
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