CN110876635A - Skin grafting tool and method for manufacturing composite skin sheet - Google Patents

Skin grafting tool and method for manufacturing composite skin sheet Download PDF

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Publication number
CN110876635A
CN110876635A CN201911328513.4A CN201911328513A CN110876635A CN 110876635 A CN110876635 A CN 110876635A CN 201911328513 A CN201911328513 A CN 201911328513A CN 110876635 A CN110876635 A CN 110876635A
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sheet
skin
crepe
wrinkles
autologous
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Inventor
肖仕初
刘攀
帅超群
夏熙明
郑勇军
姜耀男
房贺
吴琼
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Wuhan VSD Medical Science and Technology Co Ltd
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Wuhan VSD Medical Science and Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32Surgical cutting instruments
    • A61B17/322Skin grafting apparatus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/02Devices for expanding tissue, e.g. skin tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00747Dermatology
    • A61B2017/00752Hair removal or transplantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00969Surgical instruments, devices or methods, e.g. tourniquets used for transplantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32Surgical cutting instruments
    • A61B17/322Skin grafting apparatus
    • A61B2017/3225Skin grafting apparatus with processing of harvested tissue

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Pathology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Transplantation (AREA)
  • Laminated Bodies (AREA)

Abstract

The invention relates to a skin transplanting tool and a method for manufacturing a composite skin sheet by the skin transplanting tool, which comprises a crepe sheet, wherein the crepe sheet comprises a lower metal film layer and an upper gauze layer which are laminated together, and the crepe sheet is arranged above an expander; the crepe yarn sheet is provided with a plurality of transverse wrinkles and a plurality of longitudinal wrinkles; the longitudinal direction wrinkles are wrinkles of an integral crepe sheet, and the transverse direction wrinkles are wrinkles formed by folding the crepe sheet together with the longitudinal direction wrinkles. Firstly, sequentially manufacturing an autologous skin sheet and a heterologous skin sheet by a skin transplantation tool, and overlapping the autologous skin sheet and the heterologous skin sheet to form a composite skin sheet; the skin transplantation tool can carry out skin expansion transplantation according to the expansion rates of different proportions; the shape of the skin grafting area is regular, so that the skin production is rapid and uniform; solves the problem of the shortage of autologous skin sources during large-area burn.

Description

Skin grafting tool and method for manufacturing composite skin sheet
Technical Field
The invention relates to the technical field of medical instruments for clinically treating skin defects, in particular to a skin transplanting tool and a method for manufacturing a composite skin sheet by using the same.
Background
Currently, the treatment of deep burns with extra large area remains a major challenge for clinicians, with a treatment success rate of 87.1% for burn areas of 60% -69% TBSA (total surface area) and only 47.8% for burn areas greater than 90% TBSA. Timely wound surface repair is one of the keys for improving the success rate of treatment. If a patient with large-area deep burn cannot seal the wound surface in the early stage, great difficulty is brought to subsequent treatment; particularly after failure of the skin graft surgery, the available donor area for burn patients is further reduced, and the wound surface is locally infected, which makes the survival of the subsequent graft difficult. More seriously, under the condition that a large-area wound surface is exposed for a long time, the burn patient often has complications of hyper metabolism, sepsis, MODS and the like, and even endangers life. Therefore, how to repair a large area of deep wound surface by using a limited donor skin area and ensure the survival rate of transplantation is an urgent problem to be solved in the treatment of critically ill burn patients.
Currently, there is a folding flap expansion film on the market, which folds a film and a cushion layer together in the longitudinal and transverse directions into flat folds, respectively. After the skin pieces are adhered to the expansion film and cut, the skin pieces are separated from each other by stretching the expansion film in the longitudinal and transverse directions, but the drainage of the wound surface is poor during skin grafting, and the residual infection rate in the later period of repair is high.
Disclosure of Invention
The invention aims to overcome the defects of the existing skin grafting tool and provides a skin grafting tool and a method for manufacturing a composite skin sheet by using the same.
In order to achieve the purpose, the invention designs a skin transplanting tool, which comprises a crepe yarn sheet, wherein the crepe yarn sheet comprises a lower metal film layer and an upper gauze layer which are laminated together, and the crepe yarn sheet is arranged above an expander; the crepe yarn sheet is provided with a plurality of transverse wrinkles and a plurality of longitudinal wrinkles; the longitudinal direction wrinkles are wrinkles of an integral crepe sheet, and the transverse direction wrinkles are wrinkles formed by folding the crepe sheet together with the longitudinal direction wrinkles.
Further, adhesive glue is sprayed on the whole surface of the gauze layer or the contact surface of the gauze layer and the metal film layer, so that an adhesive layer is formed between the gauze layer and the metal film layer; and a plurality of rows of through holes are arranged on the crepe sheet at intervals in the transverse and longitudinal directions.
Furthermore, the bonding layer is composed of bonding adhesive tapes which are arranged in parallel at intervals in the transverse direction; the through holes are square through holes, and the adhesive tape is arranged between two rows of square through holes; the folding lines of the transverse folds and the longitudinal folds are respectively overlapped with the central lines of each row of square through holes and each column of square through holes.
Furthermore, the expander is a square frame formed by two L-shaped supports which are crossed with each other, and positioning columns are arranged on four corners of the expander.
Furthermore, positioning holes are formed in four corners of the crepe sheet, and the positioning holes are sleeved on the positioning columns so that the crepe sheet can be arranged on the expander.
Still further, all be provided with handheld part on the frame of expander.
Furthermore, the metal film layer is made of an aluminum foil layer, and the gauze layer is made of polyamide double-pleat yarns; in the crepe sheet, the unfolded length of each transverse fold is the same, and the unfolded length of each longitudinal fold is the same.
The invention also provides a method for manufacturing the composite leather sheet, which comprises the following steps:
1) preparing the autologous skin sheet:
a. taking an autologous skin sheet with the size of a cork disc by a skin taking machine according to the size of a wound surface, sticking the corium layer of the autologous skin sheet to the cork disc downwards, cutting the autologous skin sheet vertically and horizontally by a skin cutting machine, cutting the autologous skin sheet into N pieces of miniature autologous skin sheets by cutting a seam, spraying glue on the surface of the autologous skin sheet stuck to the cork disc, and sticking the surface of the autologous skin sheet to a gauze layer;
b. removing the cork disc;
c. positioning the crepe sheet laid with the leather sheet on the expander,
the crepe sheet comprises a lower metal film layer and an upper gauze layer which are laminated together, and is arranged above the expander; the crepe yarn sheet is provided with a plurality of transverse wrinkles and a plurality of longitudinal wrinkles; the longitudinal wrinkles are wrinkles of an integral crepe sheet, and the transverse wrinkles are wrinkles formed by folding the crepe sheet together with the longitudinal wrinkles; adhesive glue is sprayed on the whole surface of the gauze layer or the contact surface of the gauze layer and the metal film layer, so that an adhesive layer is formed between the gauze layer and the metal film layer; the bonding layer is composed of bonding adhesive tapes which are arranged in parallel at intervals in the transverse direction; a plurality of rows of through holes are arranged on the crepe sheet at intervals in the transverse and longitudinal directions; the adhesive tape is arranged between the two lines of square through holes; the folding lines of the transverse folds and the longitudinal folds are respectively overlapped with the central lines of each row of square through holes and each column of square through holes;
d. holding two hand-held members in the transverse direction by hands at the same time, and stretching in the transverse direction to stretch the crepe sheet in the transverse direction;
e. holding two hand-held members in the longitudinal direction by hands at the same time, and stretching in the longitudinal direction to stretch the crepe sheet in the longitudinal direction; removing the metal film layer to finally obtain an expanded autologous micro skin sheet array, namely an autologous skin sheet; and a plurality of rows of self-skin through holes which are arranged at intervals in the transverse and longitudinal directions are formed on the self-skin sheets;
2) preparing a variant leather sheet:
A. the method comprises the following steps of taking a variant leather sheet with the size corresponding to that of a cork disc through a leather taking machine according to the size of a wound surface, pasting the variant leather sheet on the cork disc with the same size, cutting the variant leather sheet vertically and horizontally through a leather cutting machine, cutting the leather sheet into N pieces of miniature variant leather sheets through cutting seams, spraying glue on the surface of the variant leather sheet pasted on the cork disc, pasting the surface of the variant leather sheet on a gauze layer, spraying glue on the surface of the leather sheet pasted on the cork disc, and turning the variant leather sheet to paste the glue surface on the gauze layer;
B. removing the cork disc;
C. positioning the crepe sheet laid with the leather sheet on the expander,
the crepe sheet comprises a lower metal film layer and an upper gauze layer which are laminated together, and the crepe sheet is arranged above the expander; the crepe yarn sheet is provided with a plurality of transverse wrinkles and a plurality of longitudinal wrinkles; the longitudinal wrinkles are wrinkles of an integral crepe sheet, and the transverse wrinkles are wrinkles formed by folding the crepe sheet together with the longitudinal wrinkles;
D. holding two hand-held members in the transverse direction by hands at the same time, and stretching in the transverse direction to stretch the crepe sheet in the transverse direction;
E. holding two hand-held members in the longitudinal direction by hands at the same time, and stretching in the longitudinal direction to stretch the crepe sheet in the longitudinal direction; removing the metal film layer to finally obtain an expanded micro variant skin sheet array, namely a variant skin sheet;
3) manufacturing the composite leather sheet:
i. firstly, the xenogenic skin sheet is laid on the dilator through the xenogenic skin positioning hole;
secondly, paving the autologous skin sheet on the dilator through the autologous skin positioning hole, and adhering the rubber surface of the adhesive layer of the autologous skin sheet and the crepe sheet of the allogeneic skin sheet to ensure that the allogeneic skin sheet and the autologous skin sheet coincide;
the autologous skin sheets and the allogeneic skin sheets are combined through the adhesive force of the adhesive layer to form an integral minitype allogeneic skin sheet, and the minitype allogeneic skin sheets respectively fall into autologous skin through holes on the expanded autologous skin sheets; thus the autologous skin piece and the allogeneic skin piece are superposed to form the composite skin piece.
Preferably, the area of the micro autologous skin sheet is C1 × C2 square millimeters; the area of the micro variant skin sheet is C1 × C2 square millimeters.
Preferably, the allogeneic skin sheets comprise allogeneic skin sheets and xenogeneic skin sheets;
the allogeneic skin is selected from allogeneic skin preserved in glycerol, allogeneic skin preserved in a deep low temperature refrigerator, allogeneic skin preserved in liquid nitrogen, acellular allogeneic skin and fresh allogeneic skin;
the xenogenic skin sheet is selected from acellular dermal matrix pigskin sheet, acellular dermal matrix sheep skin sheet, acellular dermal matrix frog skin sheet and fresh pigskin sheet.
Preferably, the allogeneic skin sheet is a glycerin-preserved allogeneic skin sheet, and the xenogeneic skin sheet is a full-thickness acellular dermal matrix pigskin sheet.
The invention has the beneficial effects that:
the skin transplantation tool can carry out skin expansion transplantation according to the expansion rates of different proportions; the shape of the skin grafting area is regular, so that the skin production is rapid and uniform; solves the problem of the shortage of autologous skin sources during large-area burn.
Drawings
FIG. 1 is a schematic view of a skin grafting tool;
FIG. 2 is a schematic view of the construction of the dilator;
figure 3 is a perspective view of a crepe sheet;
FIG. 4 is an enlarged view of point A of FIG. 3;
FIG. 5 is an enlarged view of point B of FIG. 3;
figure 6 is a schematic diagram of a crepe sheet;
FIG. 6A is a diagram of the initial state of a crepe sheet; FIG. 6B is a drawing of a crepe sheet punch; figure 6C is a longitudinal fold of a crepe sheet; figure 6D is a schematic view of longitudinal folding of a crepe sheet; figure 6E is a cross-fold view of a crepe sheet; FIG. 6F is a crepe sheet fold forming diagram;
FIG. 7 is a schematic view of the bonded layer of crepe sheet shown in FIG. 6;
figure 8 is a schematic size diagram of a crepe sheet;
figure 9 is a schematic illustration of another crepe sheet making process;
figure 9A is a longitudinal fold of a crepe sheet; figure 9B is a schematic view of longitudinal folding of a crepe sheet; figure 9C is a cross-fold view of a crepe sheet; FIG. 9D is a crepe sheet fold forming diagram;
FIG. 10 is a schematic view in the Y direction of FIGS. 6 and 9;
FIG. 11 is a schematic view in the X direction of FIGS. 6 and 9;
FIG. 12 is a drawing of the manufacturing process of the skin patch;
FIG. 13 is a drawing-up view of the dilator;
FIG. 14 is a top view of an autologous skin sheet;
FIG. 15 is a bottom view of an autologous skin sheet;
FIG. 16 is a schematic view of an allogeneic dermal sheet;
FIG. 17 is a schematic view of the production of a composite skin sheet;
FIG. 18 is a schematic view of a composite skin sheet;
in the figure, crepe yarn sheet 1, metal film layer 1.1, longitudinal wrinkles 1.5, gauze layer 1.2, adhesive layer 1.3, adhesive tape 1.31, transverse wrinkles 1.4, longitudinal wrinkles 1.5, through holes 1.6, positioning holes 1.7, folding lines 1.8, expander 2, L-shaped bracket 2.1, positioning column 2.2, hand-held part 2.3, cork disc 3, autologous leather sheet 4, kerf 4.1, micro autologous leather sheet 4.2, autologous leather sheet 5, autologous leather positioning hole 5.1, autologous leather square hole 5.2, allogeneic leather sheet 6, micro allogeneic leather sheet 6.1, allogeneic leather sheet 7, allogeneic leather positioning hole 7.1 and composite leather sheet 8.
Detailed Description
The present invention is described in further detail below with reference to specific examples so as to be understood by those skilled in the art.
Example 1
The skin grafting tool shown in fig. 1 to 7, 10 and 11 comprises a crepe sheet 1, wherein the crepe sheet comprises a lower metal film layer 1.1 and an upper gauze layer 1.2 which are laminated together, the metal film layer 1.1 is an aluminum foil layer, and the gauze layer 1.2 is polyamide double-fold gauze;
the crepe sheet 1 is arranged above the expander 2; the expander 2 is a square frame formed by mutually crossing two L-shaped supports 2.1, and positioning columns 2.2 are arranged at four corners of the expander 2; the frames of the expanders 2 are provided with handheld parts 2.3;
the crepe sheet 1 is provided with a plurality of transverse folds 1.4 and a plurality of longitudinal folds 1.5; the longitudinal wrinkles 1.5 are the wrinkles of the integral crepe sheet 1, the transverse wrinkles are the wrinkles which fold the crepe sheet 2 together with the longitudinal wrinkles 1.5, the unfolding length of each transverse wrinkle is the same, and the unfolding length of each longitudinal wrinkle is the same;
an adhesive layer 1.3 is laid between the gauze layer 1.2 and the metal film layer 1.1; the adhesive layer 1.3 is formed by adhesive tapes 1.31 which are arranged in parallel at intervals and transversely on the adhesive layer 1.3; the through holes are square through holes 1.6, and the adhesive tape 1.31 is arranged between two lines of square through holes 1.6
Positioning holes 1.7 are formed in four corners of the crepe sheet 1, and the positioning holes 1.7 are sleeved on the positioning columns 2.2 to enable the crepe sheet 1 to be arranged on the expander 2; in the initial state of the expander 5, the distance between the positioning posts 2.2 is L1 XL 1 which just corresponds to the four positioning holes 2.3 of the folded skin-planted crepe sheet (the center distance of the positioning holes 1.7 is L1 XL 1, as shown in figure 8)
Above-mentioned skin transplantation instrument still needs supporting cork dish 3 at the skin grafting in-process, and this cork dish 3 is current product, only needs purchase again on the market.
In this embodiment, the cork plate is a square plate with an L × L outer shape (as shown in FIG. 12, L × L).
The method of using the skin grafting tool for autologous skin sheets as shown in fig. 12 to 15 comprises:
a. in the skin grafting process, a corresponding amount of the self-body skin 4 is taken by a skin taking machine according to the size of a wound surface, the corium layer of the self-body skin 4 faces downwards and is pasted on a cork disc 3, the self-body skin is cut vertically and horizontally by a skin cutting machine, the self-body skin 4 is divided into N pieces of miniature self-body skin 4.1 by a cutting seam (the area of each miniature self-body skin 4.1 is C1 multiplied by C2 square millimeters), glue is sprayed on the surface of the skin of the self-body skin 4 pasted on the cork disc 3, and then the surface of the skin is pasted on a gauze layer 1.2;
b. removing the cork discs 3;
c. positioning the crepe sheet 1 with the leather sheet laid on the expander 2 (positioning holes 1.7 on four corners of the crepe sheet are respectively sleeved on positioning columns 2.2 on four corners of the expander),
d. holding the two holding parts 2.3 in the transverse direction by hand simultaneously, stretching in the transverse direction, thereby spreading the crepe sheet in the transverse direction;
e. holding two hand-held parts 2.3 in the longitudinal direction by hand at the same time, stretching in the longitudinal direction to spread the crepe sheet 1 in the longitudinal direction; removing the metal film layer 1.1 to finally obtain an expanded autologous micro skin sheet array, namely an autologous skin sheet 5; and a plurality of rows of self-skin through holes 5.2 (shown in figure 14) which are arranged at intervals in the transverse and longitudinal directions are formed on the self-skin sheet 5;
as shown in fig. 14, the expanded micro flap array has the unfolding lengths of the transverse folds and the longitudinal folds of S1 and S2, where 1.3 are square holes arranged in the transverse direction and the vertical direction at intervals, the area corresponding to the expanded micro flap array is (C1+ S1) × (C1+ S2) square millimeters, which is equivalent to the skin grafting area of the flap array is enlarged by (C1+ S1) × (C1+ S2)/C1 × C1, and C1, S1, and S2 can be selected according to clinical practical needs.
As shown in fig. 15: the back surface of the utility model is longitudinally paved with adhesive tapes 1.31 along the interval square through holes 1.6.
Example 2
The skin grafting tool shown in fig. 1 to 7 and 9 to 11 comprises a crepe sheet 1, wherein the crepe sheet comprises a lower metal film layer 1.1 and an upper gauze layer 1.2 which are laminated together, the metal film layer 1.1 is an aluminum foil layer, and the gauze layer 1.2 is polyamide double-fold gauze;
the crepe sheet 1 is arranged above the expander 2; the expander 2 is a square frame formed by mutually crossing two L-shaped supports 2.1, and positioning columns 2.2 are arranged at four corners of the expander 2; the frames of the expanders 2 are provided with handheld parts 2.3;
the crepe sheet 1 is provided with a plurality of transverse folds 1.4 and a plurality of longitudinal folds 1.5; the longitudinal wrinkles 1.5 are the wrinkles of the integral crepe sheet 1, the transverse wrinkles are the wrinkles which fold the crepe sheet 2 together with the longitudinal wrinkles 1.5, the unfolding length of each transverse wrinkle is the same, and the unfolding length of each longitudinal wrinkle is the same; .
Positioning holes 1.7 are formed in four corners of the crepe sheet 1, and the positioning holes 1.7 are sleeved on the positioning columns 2.2 to enable the crepe sheet 1 to be arranged on the expander 2; in the initial state of the expander 5, the distance between the positioning posts 2.2 is L1 × L1, which exactly corresponds to the four positioning holes 2.3 of the folded skin-implanted crepe sheet.
The method of making the allogeneic skin sheet using the skin grafting tool described above is substantially the same as in example 1:
A. the method comprises the following steps of taking variant leather sheets 6 with the size corresponding to that of a cork disc through a leather taking machine according to the size of a wound surface, attaching the variant leather sheets to the cork disc 3 with the same size, cutting the variant leather sheets vertically and horizontally through a leather cutting machine, dividing the leather sheets into N pieces of miniature variant leather sheets 6.1 through cutting seams, spraying glue on the surface of the variant leather sheets 6 attached to the cork disc 3, attaching the surface of the variant leather sheets 6 to a gauze layer 1.2, spraying glue on the surface of the leather sheets 4 attached to the cork disc, and turning the variant leather sheets to enable the glue surface to be attached to the gauze layer 1.2;
B. removing the cork discs 3;
C. positioning the crepe sheet 1 with the leather sheet laid on the expander 2,
D. holding the two holding members 2.3 in the transverse direction by hand simultaneously, stretching in the transverse direction, thereby spreading the crepe sheet 1 in the transverse direction;
E. holding two hand-held parts 2.3 in the longitudinal direction by hand at the same time, stretching in the longitudinal direction to spread the crepe sheet 1 in the longitudinal direction; and removing the metal film layer 1.1 to finally obtain an expanded micro variant skin sheet array, namely a variant skin sheet 7 (figure 16).
As shown in fig. 16: variant leather piece 6 evenly interval distribution forms variant leather piece 7 (like miniature leather piece 7) on gauze layer 1.2 after the cutting extension, and its four corners respectively has a locating hole 7.1.
The allogeneic skin sheet 6 comprises an allogeneic skin sheet and an allogeneic skin sheet; the allogeneic skin sheet is selected from allogeneic skin sheet preserved in glycerol, allogeneic skin sheet preserved in deep low temperature refrigerator, allogeneic skin sheet preserved in liquid nitrogen, decellularized allogeneic skin sheet or fresh allogeneic skin sheet; the heterogenous skin is selected from acellular dermal matrix pigskin, acellular dermal matrix sheep skin, acellular dermal matrix frog skin and fresh pigskin.
Example 3
A method of making a composite skin sheet as shown in fig. 16, comprising the steps of:
i. firstly, the variant leather sheet 7 is laid on the dilator 2 through the variant leather positioning hole 7.1;
secondly, the autologous skin sheet 5 is laid on the dilator 2 through the autologous skin positioning hole 5.1, and the rubber surface of the bonding layer of the autologous skin sheet 5 is bonded with the crepe sheet 2 of the allogeneic skin sheet 7, so that the allogeneic skin sheet 7 and the autologous skin sheet 5 are superposed;
the autologous skin sheet 5 and the allogeneic skin sheet 7 are combined through the adhesive force of the adhesive layer to form an integral micro allogeneic skin sheet 7.1, and the micro allogeneic skin sheet 7.1 falls into the autologous skin through holes 5.2 on the expanded autologous skin sheet 5 respectively; thus, the autologous skin sheet 5 and the allogeneic skin sheet 7 are superposed to form a composite skin sheet 8.
The composite skin 8 shown in fig. 17 can be transplanted to a skin defect.
Other parts not described in detail are prior art. Although the present invention has been described in detail with reference to the above embodiments, it is only a part of the embodiments of the present invention, not all of the embodiments, and other embodiments can be obtained without inventive step according to the embodiments, and the embodiments are within the scope of the present invention.

Claims (9)

1. A skin grafting tool, it includes crepe yarn piece (1), crepe yarn piece (1) includes metal membranous layer (1.1) and gauze layer (1.2) of upper strata of lower floor that laminate together, its characterized in that: the crepe sheet (1) is arranged above the expander (2); the crepe sheet (1) is provided with a plurality of transverse folds (1.4) and a plurality of longitudinal folds (1.5); the longitudinal folds (1.5) are folds of the integral crepe sheet (1), and the transverse folds are folds of the crepe sheet (2) together with the longitudinal folds (1.5).
2. The skin grafting tool of claim 1, wherein: adhesive glue is sprayed on the whole surface of the gauze layer (1.2) or the contact surface of the gauze layer and the metal film layer (1.1), so that an adhesive layer (1.3) is formed between the gauze layer (1.2) and the metal film layer (1.1); multiple rows of through holes (1.6) are arranged on the crepe yarn sheet (1) at intervals transversely and longitudinally.
3. The skin grafting tool of claim 2, wherein: the bonding layer (1.3) is composed of bonding adhesive tapes (1.31) which are arranged at intervals and transversely in parallel; the through holes (1.6) are square through holes, and the adhesive tape (1.31) is arranged between two rows of square through holes (1.6); the folding lines (1.7) of the transverse pleats (1.4) and the longitudinal pleats (1.5) are respectively overlapped with the central lines of each row of square through holes (1.6) and each column of square through holes (1.6).
4. The skin grafting tool of claim 1, wherein: the expander (2) is formed into a square frame by two L-shaped supports (2.1) which are mutually crossed, and positioning columns (2.2) are arranged on four corners of the expander (2).
5. The skin grafting tool of claim 4, wherein: positioning holes (1.7) are formed in four corners of the crepe sheet (1), and the positioning holes (1.7) are sleeved on the positioning columns (2.2) so that the crepe sheet (1) can be arranged on the expander (2).
6. The skin grafting tool of claim 1, wherein: the frame of the expander (2) is provided with a handheld part (2.3).
7. The skin grafting tool of claim 1, wherein: the metal film layer (1.1) is made of an aluminum foil layer, and the gauze layer (1.2) is made of polyamide double-pleat yarns; in the crepe sheet (1), the unfolded length of each transverse fold (1.4) is the same, and the unfolded length of each longitudinal fold (1.5) is the same.
8. A method for manufacturing a composite leather sheet is characterized by comprising the following steps: the method comprises the following steps:
1) preparing the autologous skin sheet:
a. the method comprises the following steps of (1) taking an autologous skin sheet with the size equal to that of a cork disc by a skin taking machine, enabling a corium layer of the autologous skin sheet to face downwards and be attached to the cork disc, cutting the autologous skin sheet longitudinally and transversely by a skin cutting machine, cutting the autologous skin sheet into N pieces of miniature autologous skin sheets by cutting a seam, spraying glue on the surface of the autologous skin sheet attached to the cork disc, and then attaching the surface of the autologous skin sheet to a gauze layer;
b. removing the cork disc;
c. positioning the crepe sheet laid with the leather sheet on the expander,
the crepe sheet comprises a lower metal film layer and an upper gauze layer which are laminated together, and is arranged above the expander; the crepe yarn sheet is provided with a plurality of transverse wrinkles and a plurality of longitudinal wrinkles; the longitudinal wrinkles are wrinkles of an integral crepe sheet, and the transverse wrinkles are wrinkles formed by folding the crepe sheet together with the longitudinal wrinkles; adhesive glue is sprayed on the whole surface of the gauze layer or the contact surface of the gauze layer and the metal film layer, so that an adhesive layer is formed between the gauze layer and the metal film layer; the bonding layer is composed of bonding adhesive tapes which are arranged in parallel at intervals in the transverse direction; a plurality of rows of through holes are arranged on the crepe sheet at intervals in the transverse and longitudinal directions; the adhesive tape is arranged between the two lines of square through holes; the folding lines of the transverse folds and the longitudinal folds are respectively overlapped with the central lines of each row of square through holes and each column of square through holes;
d. holding two hand-held members in the transverse direction by hands at the same time, and stretching in the transverse direction to stretch the crepe sheet in the transverse direction;
e. holding two hand-held members in the longitudinal direction by hands at the same time, and stretching in the longitudinal direction to stretch the crepe sheet in the longitudinal direction; removing the metal film layer to finally obtain an expanded autologous micro skin sheet array, namely an autologous skin sheet; and a plurality of rows of self-skin through holes which are arranged at intervals in the transverse and longitudinal directions are formed on the self-skin sheets;
2) preparing a variant leather sheet:
A. the method comprises the following steps of taking a variant leather sheet with the size corresponding to that of a cork disc through a leather taking machine, attaching the variant leather sheet to the cork disc with the same size, cutting the variant leather sheet vertically and horizontally through a leather cutting machine, cutting the leather sheet into N pieces of miniature variant leather sheets through a cutting seam, spraying glue on the surface of the variant leather sheet attached to the cork disc, attaching the surface of the variant leather sheet to a gauze layer, spraying glue on the surface of the leather sheet attached to the cork disc, and turning the variant leather sheet to enable the glue surface to be attached to the gauze layer;
B. removing the cork disc;
C. positioning the crepe sheet laid with the leather sheet on the expander,
the crepe sheet comprises a lower metal film layer and an upper gauze layer which are laminated together, and the crepe sheet is arranged above the expander; the crepe yarn sheet is provided with a plurality of transverse wrinkles and a plurality of longitudinal wrinkles; the longitudinal wrinkles are wrinkles of an integral crepe sheet, and the transverse wrinkles are wrinkles formed by folding the crepe sheet together with the longitudinal wrinkles;
D. holding two hand-held members in the transverse direction by hand at the same time, and stretching in the transverse direction to spread out the crepe sheet 1 in the transverse direction;
E. holding two hand-held members in the longitudinal direction by hands at the same time, and stretching in the longitudinal direction to stretch the crepe sheet in the longitudinal direction; removing the metal film layer to finally obtain an expanded micro variant skin sheet array, namely a variant skin sheet;
3) manufacturing the composite leather sheet:
i. firstly, the xenogenic skin sheet is laid on the dilator through the xenogenic skin positioning hole;
secondly, paving the autologous skin sheet on the dilator through the autologous skin positioning hole, and adhering the rubber surface of the adhesive layer of the autologous skin sheet and the crepe sheet of the allogeneic skin sheet to ensure that the allogeneic skin sheet and the autologous skin sheet coincide;
the autologous skin sheets and the allogeneic skin sheets are combined through the adhesive force of the adhesive layer to form an integral minitype allogeneic skin sheet, and the minitype allogeneic skin sheets respectively fall into autologous skin through holes on the expanded autologous skin sheets; thus the autologous skin piece and the allogeneic skin piece are superposed to form the composite skin piece.
9. The method of making a composite skin according to claim 1, wherein:
the allogeneic skin is selected from allogeneic skin preserved in glycerol, allogeneic skin preserved in a deep low temperature refrigerator, allogeneic skin preserved in liquid nitrogen, acellular allogeneic skin and fresh allogeneic skin;
the xenogenic skin sheet is selected from acellular dermal matrix pigskin sheet, acellular dermal matrix sheep skin sheet, acellular dermal matrix frog skin sheet and fresh pigskin sheet.
CN201911328513.4A 2019-12-20 2019-12-20 Skin grafting tool and method for manufacturing composite skin sheet Pending CN110876635A (en)

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Application Number Priority Date Filing Date Title
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111888526A (en) * 2020-06-16 2020-11-06 陈翔 Skin sheet for mixed transplantation of heterogeneous species
CN114376682A (en) * 2022-01-16 2022-04-22 湖南峰博医疗器械科技有限公司 Single-layer leather sheet expanding slide glass and preparation instrument thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111888526A (en) * 2020-06-16 2020-11-06 陈翔 Skin sheet for mixed transplantation of heterogeneous species
CN114376682A (en) * 2022-01-16 2022-04-22 湖南峰博医疗器械科技有限公司 Single-layer leather sheet expanding slide glass and preparation instrument thereof

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