CN110876635A - Skin grafting tool and method for making composite skin grafts - Google Patents

Abstract

The invention relates to a skin transplanting tool and a method for manufacturing a composite skin sheet by the skin transplanting tool, which comprises a crepe sheet, wherein the crepe sheet comprises a lower metal film layer and an upper gauze layer which are laminated together, and the crepe sheet is arranged above an expander; the crepe yarn sheet is provided with a plurality of transverse wrinkles and a plurality of longitudinal wrinkles; the longitudinal direction wrinkles are wrinkles of an integral crepe sheet, and the transverse direction wrinkles are wrinkles formed by folding the crepe sheet together with the longitudinal direction wrinkles. Firstly, sequentially manufacturing an autologous skin sheet and a heterologous skin sheet by a skin transplantation tool, and overlapping the autologous skin sheet and the heterologous skin sheet to form a composite skin sheet; the skin transplantation tool can carry out skin expansion transplantation according to the expansion rates of different proportions; the shape of the skin grafting area is regular, so that the skin production is rapid and uniform; solves the problem of the shortage of autologous skin sources during large-area burn.

Description

Skin grafting tool and method for making composite skin grafts

technical field

The invention relates to the technical field of medical devices for clinical treatment of skin defects, in particular to a skin grafting tool and a method for making a composite skin sheet.

Background technique

At present, the treatment of extra-large area deep burns is still a major challenge for clinicians. When the burn area is 60%-69% TBSA (total surface area), the success rate of treatment is 87.1%, while when the burn area is greater than 90% TBSA, the treatment success rate is only 47.8%. Timely repair of wounds is one of the keys to improving the success rate of treatment. If the large-area deep burn patients cannot close the wound in the early stage, it will bring great difficulty to the subsequent treatment; especially after the skin grafting operation fails, the available donor area for the burn patient is further reduced, and the wound surface is affected by local infection. , which makes the survival of subsequent skin grafts difficult. What's more serious is that burn patients often suffer from complications such as hypermetabolism, sepsis, MODS and even life-threatening when large-area wounds are exposed for a long time. Therefore, how to use a limited donor site to repair a large area of deep wounds and ensure the survival rate of transplantation is an urgent problem to be solved in the treatment of critically burned patients.

At present, there is a foldable skin expansion film on the market, and the expansion film folds the film and the cushion together into a flat fold in the longitudinal and transverse directions, respectively. After the skin sheets are pasted on the expansion membrane and cut, the expansion membranes are stretched vertically and horizontally to separate the skin sheets from each other, but the wound drainage is poor during skin grafting, and the residual infection rate in the later stage of repair is high.

SUMMARY OF THE INVENTION

The purpose of the present invention is to overcome the defects of the existing skin grafting tools, and provide a skin grafting tool and a method for making a composite skin graft.

In order to achieve the above object, the present invention designs a skin grafting tool, which includes a crepe sheet, the crepe sheet includes a lower metal film layer and an upper gauze layer that are stacked together, and the crepe sheet is arranged above the dilator; The crepe sheet is provided with a plurality of transverse pleats and a plurality of longitudinal pleats; the longitudinal pleats are pleats of the whole crepe sheet, and the transverse pleats are pleats obtained by folding the crepe sheet together with the longitudinal pleats.

Further, the whole surface of the gauze layer or the contact surface with the metal film layer is sprayed with adhesive, so as to form an adhesive layer between the gauze layer and the metal film layer; the crepe sheet is provided with multiple rows of through holes at horizontal and vertical intervals. .

Still further, the adhesive layer is composed of adhesive tapes arranged in parallel and at intervals; the through holes are square through holes, and the adhesive tape is arranged between two rows of square through holes; the transverse folds and The folding lines of the longitudinal folds respectively coincide with the center lines of each row of square through holes and each column of square through holes.

Still further, the expander is formed by two L-shaped brackets intersecting each other to form a square frame, and four corners of the expander are provided with positioning posts.

Still further, four corners of the crepe sheet are provided with positioning holes, and the positioning holes are sleeved on the positioning posts so that the crepe sheet is arranged on the expander.

Still further, a hand-held component is provided on the frame of the dilator.

Still further, the material of the metal film layer is an aluminum foil layer, and the material of the gauze layer is a polyamide double pleated yarn; in the crepe sheet, the unfolded length of each transverse fold is the same, and the unfolded length of each longitudinal fold is the same. same.

The present invention also provides a method for making a composite skin sheet, comprising the following steps:

1) The production of autologous skin grafts:

a. According to the size of the wound, a cork plate-sized autologous skin piece was taken by a skin harvester. The dermis layer of the autologous skin piece was attached to the cork plate with the dermis layer facing down, and the skin was cut vertically and horizontally with a skin cutter. For the miniature autologous skin piece, spray glue on the epidermis of the autologous skin piece attached to the cork plate, and then stick the epidermis surface of the skin piece on the gauze layer;

b. Remove the cork tray;

c. Position the crepe sheet with the skin sheet on the dilator,

Wherein, the crepe sheet includes a lower metal film layer and an upper gauze layer that are stacked together, and the crepe sheet is arranged above the dilator; the crepe sheet is provided with a plurality of transverse folds and a plurality of longitudinal folds; the The longitudinal wrinkle is the wrinkle of the whole crepe sheet, and the transverse wrinkle is the wrinkle that folds the crepe sheet together with the longitudinal wrinkle; An adhesive layer is formed between the film layers; and the adhesive layer is composed of adhesive tapes arranged at intervals and in parallel horizontally; the crepe sheet is provided with multiple rows of through holes at horizontal and vertical intervals; and the adhesive tape is provided with two rows of square through holes. the center lines of each row of square through holes and each column of square through holes respectively overlap;

d. Hold the two hand-held parts in the transverse direction at the same time by hand, and stretch in the transverse direction, so as to stretch the crepe sheet in the transverse direction;

e. Hold the two hand-held parts in the longitudinal direction at the same time by hand, stretch in the longitudinal direction to stretch the crepe sheet in the longitudinal direction; remove the metal film layer and finally obtain an expanded autologous microskin array, which is the autologous skin and multiple rows of autologous skin through-holes are formed at horizontal and vertical intervals on the autologous skin sheet;

2) Production of allogeneic skin grafts:

A. According to the size of the wound, take the allogeneic skin piece corresponding to the size of the cork plate through a skin extractor, stick it on the cork plate of the same size, cut it vertically and horizontally with a skin cutter, and divide the skin piece into N pieces of micro allogeneic skin. , spray glue on the epidermis surface of the allogeneic skin piece attached to the cork plate, and then stick the skin surface of the allograft skin piece on the gauze layer and spray glue on the surface of the skin piece stuck on the cork plate, then turn it over to put the glue surface Reposted on the gauze layer;

B. Remove the cork tray;

C. Position the crepe sheet with the skin sheet on the dilator,

The crepe sheet includes a lower metal film layer and an upper gauze layer that are stacked together, the crepe sheet includes a lower metal film layer and an upper gauze layer that are stacked together, and the crepe sheet is disposed above the dilator; The crepe sheet is provided with a plurality of transverse pleats and a plurality of longitudinal pleats; the longitudinal pleats are pleats of the whole crepe sheet, and the transverse pleats are pleats obtained by folding the crepe sheet together with the longitudinal pleats;

D. Hold the two hand-held parts in the transverse direction at the same time by hand, and stretch in the transverse direction, so as to stretch the crepe sheet in the transverse direction;

E. Hold the two hand-held parts in the longitudinal direction at the same time by hand, and stretch in the longitudinal direction to stretch the crepe sheet in the longitudinal direction; remove the metal film layer and finally get the expanded micro allograft skin sheet array, which is the allograft skin skin;

3) Production of composite skin sheet:

i. First, the above-mentioned allogeneic skin sheet is laid on the dilator through the allogeneic skin positioning hole;

ii. Then the above-mentioned autologous skin sheet is laid on the dilator through the autologous skin positioning hole, and the glue surface of the adhesive layer of the autologous skin sheet is bonded with the crepe sheet of the allogeneic skin sheet to make the allogeneic skin sheet and the autologous skin sheet. skin overlap;

iii. The autologous skin sheet and the allogeneic skin sheet are combined by the adhesive force of the adhesive layer to form a whole micro allogeneic skin sheet, and the micro allogeneic skin sheet respectively falls into the autologous skin through holes on the expanded autologous skin sheet ; So the autologous skin sheet and the allogeneic skin sheet are superimposed to form a composite skin sheet.

As a preferred solution, the area of the micro autologous skin sheet is C1×C2 square millimeters; the area of the micro allogeneic skin sheet is C1×C2 square millimeters.

As a preferred solution, the allogeneic skin patch includes an allogeneic skin patch and a xenogeneic skin patch;

The allografts are selected from glycerol-preserved allografts, deep-low temperature refrigerator-preserved allografts, liquid nitrogen-preserved allografts, acellular allografts and fresh allografts. Allogeneic skin graft;

The xenogeneic skin sheet is selected from acellular dermal matrix pigskin sheet, acellular dermal matrix sheepskin sheet, acellular dermal matrix frog skin sheet and fresh pig skin sheet.

As a preferred solution, the allogeneic skin sheet is a glycerol-preserved allogeneic skin sheet, and the allogeneic skin sheet is a full-thickness acellular dermal matrix pig skin sheet.

Beneficial effects of the present invention:

The skin transplantation tool of the invention can carry out skin expansion and transplantation according to the expansion rate of different proportions; the shape of the skin transplantation area is regular, so that the skin is produced quickly and evenly;

Description of drawings

FIG. 1 is a schematic structural diagram of a skin grafting tool;

Fig. 2 is the structural representation of the dilator;

Figure 3 is a perspective view of a crepe sheet;

Fig. 4 is an enlarged view of point A of Fig. 3;

Fig. 5 is the enlarged view of point B of Fig. 3;

Fig. 6 is a kind of production schematic diagram of crepe sheet;

6A is a diagram of the initial state of the crepe sheet; FIG. 6B is a punching diagram of the crepe sheet; FIG. 6C is a longitudinal folding diagram of the crepe sheet; FIG. 6D is a schematic diagram of the longitudinal folding of the crepe sheet; Sheet folding forming diagram;

Fig. 7 is the schematic diagram of the crepe sheet adhesive layer shown in Fig. 6;

Fig. 8 is the dimension schematic diagram of crepe sheet;

Fig. 9 is the production schematic diagram of another kind of crepe sheet;

Fig. 9A is a longitudinal folding diagram of a crepe sheet; Fig. 9B is a schematic diagram of the longitudinal folding of a crepe sheet; Fig. 9C is a transverse folding diagram of the crepe sheet; Fig. 9D is a folding and forming diagram of the crepe sheet;

Fig. 10 is the Y direction schematic diagram of Fig. 6 and Fig. 9;

Fig. 11 is the X direction schematic diagram of Fig. 6 and Fig. 9;

Fig. 12 is the manufacturing process diagram of the leather piece;

Fig. 13 is the pull-up diagram of the dilator;

Figure 14 is a top view of an autologous skin graft;

Figure 15 is a bottom view of the autologous skin graft;

Figure 16 is a schematic diagram of an allogeneic skin patch;

Fig. 17 is the production schematic diagram of composite skin;

Figure 18 is a schematic diagram of a composite skin;

In the figure, crepe sheet 1, metal film layer 1.1, longitudinal fold 1.5, gauze layer 1.2, adhesive layer 1.3, adhesive tape 1.31, transverse fold 1.4, longitudinal fold 1.5, through hole 1.6, positioning hole 1.7, folding line 1.8, Expander 2, L-shaped stent 2.1, positioning post 2.2, hand-held part 2.3, cork plate 3, autologous skin sheet 4, incision 4.1, micro autologous skin sheet 4.2, autologous skin sheet 5, autologous skin positioning hole 5.1, autologous skin Square hole 5.2, allogeneic skin sheet 6, micro allogeneic skin sheet 6.1, allogeneic skin sheet 7, allogeneic skin positioning hole 7.1, composite skin sheet 8.

Detailed ways

The present invention will be further described in detail below with reference to specific embodiments, so as to be understood by those skilled in the art.

Example 1

As shown in Figures 1 to 7, 10 and 11, the skin grafting tool includes a crepe sheet 1, the crepe sheet includes a lower metal film layer 1.1 and an upper gauze layer 1.2 laminated together, and the material of the metal film layer 1.1 is It is an aluminum foil layer, and the material of the gauze layer 1.2 is polyamide double pleated yarn;

The crepe sheet 1 is arranged above the expander 2; the expander 2 is formed by two L-shaped brackets 2.1 crossing each other to form a square frame, the four corners of the expander 2 are provided with positioning posts 2.2;

The crepe sheet 1 is provided with a plurality of transverse folds 1.4 and a plurality of longitudinal folds 1.5; the longitudinal folds 1.5 are the folds of the whole crepe sheet 1, and the transverse folds are the crepe sheets 2 and the longitudinal folds 1.5 are folded together. The unfolding of each transverse fold The length is the same, and the unfolded length of each longitudinal fold is the same;

An adhesive layer 1.3 is laid between the gauze layer 1.2 and the metal film layer 1.1; the adhesive layer 1.3 is composed of an adhesive tape 1.31 arranged at intervals and in parallel horizontally; the through hole is a square through hole 1.6, and The adhesive tape 1.31 is provided between the two columns of square through holes 1.6

The four corners of the crepe sheet 1 are provided with positioning holes 1.7, and the positioning holes 1.7 are sleeved on the positioning posts 2.2 so that the crepe sheet 1 is set on the expander 2; in the initial state of the expander 5, the distance between the positioning posts 2.2 is L1× L1 just corresponds to the four positioning holes 2.3 of the folded skin grafted crepe sheet (the center distance of the positioning holes 1.7 is L1×L1, as shown in Figure 8)

During the skin grafting process, the above-mentioned skin grafting tool also needs to be equipped with a cork tray 3, and the cork tray 3 is an existing product and only needs to be purchased in the market.

In this embodiment, the cork disk is a square disk body with an L×L shape (as shown in FIG. 12 , L×L).

As shown in Figures 12-15, the method of autologous skin grafting using the above-mentioned skin grafting tools:

a. In the process of skin grafting, according to the size of the wound, take a corresponding amount of autologous skin piece 4 through a skin harvester, and paste the dermis layer of the autologous skin piece 4 on the cork plate 3 with the dermis layer facing down. Piece 4 is divided into N pieces of miniature autologous skin sheet 4.1 (the area of each miniature autologous skin sheet 4.1 is C1×C2 square millimeters), spray glue on the epidermis surface of autologous skin sheet 4 pasted on cork plate 3, and then peel the skin. The epidermis of the sheet is attached to the gauze layer 1.2;

b. Remove the cork tray 3;

c. Position the crepe sheet 1 on which the skin sheet is laid on the expander 2 (the positioning holes 1.7 on the four corners of the crepe sheet are respectively sleeved on the positioning posts 2.2 on the four corners of the expander),

d. Hold the two hand-held parts 2.3 in the transverse direction at the same time by hand, and stretch in the transverse direction, thereby extending the crepe sheet in the transverse direction;

e. Hold the two hand-held parts 2.3 in the longitudinal direction at the same time by hand, and stretch in the longitudinal direction to stretch the crepe sheet 1 in the longitudinal direction; remove the metal film layer 1.1 and finally obtain an expanded autologous micro-skin sheet array, which is Autologous skin sheet 5; and multiple rows of autologous skin through holes 5.2 (as shown in Figure 14) are formed on the autologous skin sheet 5 at horizontal and vertical intervals;

As shown in Figure 14, the expanded micro-skin array, the unfolded lengths of the transverse and longitudinal folds are S1 and S2, of which 1.3 is a square hole arranged at intervals along the horizontal and vertical directions. The expanded micro-skin corresponds to The area is (C1+S1)×(C1+S2) square millimeters, which is equivalent to expanding the skin grafting area of the skin by (C1+S1)×(C1+S2)/C1×C1 times, C1, S1, S2 can be Choose according to actual clinical needs.

As shown in Figure 15: the back side is longitudinally laid with adhesive tape 1.31 along the spaced square through holes 1.6.

Example 2

As shown in Figures 1 to 7 and 9 to 11, the skin grafting tool includes a crepe sheet 1, and the crepe sheet includes a lower metal film layer 1.1 and an upper gauze layer 1.2 that are stacked together. The material of the metal film layer 1.1 is It is an aluminum foil layer, and the material of the gauze layer 1.2 is polyamide double pleated yarn;

The crepe sheet 1 is arranged above the expander 2; the expander 2 is formed by two L-shaped brackets 2.1 crossing each other to form a square frame, the four corners of the expander 2 are provided with positioning posts 2.2;

The crepe sheet 1 is provided with a plurality of transverse folds 1.4 and a plurality of longitudinal folds 1.5; the longitudinal folds 1.5 are the folds of the whole crepe sheet 1, and the transverse folds are the crepe sheets 2 and the longitudinal folds 1.5 are folded together. The unfolding of each transverse fold The length is the same, and the unfolded length of each longitudinal fold is the same;

The four corners of the crepe sheet 1 are provided with positioning holes 1.7, and the positioning holes 1.7 are sleeved on the positioning posts 2.2 so that the crepe sheet 1 is set on the expander 2; in the initial state of the expander 5, the distance between the positioning posts 2.2 is L1× L1 just corresponds to the four positioning holes 2.3 of the folded skin-grafted crepe sheet.

The method for making allogeneic skin grafts using the above-mentioned skin grafting tools is basically the same as that in Example 1:

A. According to the size of the wound, take an allogeneic skin piece 6 corresponding to the size of the cork plate through a skin extractor, stick it on a cork plate 3 of the same size, cut it vertically and horizontally with a skin cutter, and divide the skin piece into N pieces of miniature pieces. Allogeneic skin sheet 6.1, spray glue on the epidermis of the foreign skin sheet 6 attached to the cork plate 3, then stick the skin surface of the foreign skin sheet 6 on the gauze layer 1.2, and spray glue on the surface of the skin sheet 4 attached to the cork plate , and then turn it over to transfer the adhesive surface to the gauze layer 1.2;

B. Remove the cork tray 3;

C. Position the crepe sheet 1 with the skin sheet on the dilator 2,

D. Hold the two hand-held parts 2.3 in the transverse direction at the same time by hand, and stretch in the transverse direction, thereby extending the crepe sheet 1 in the transverse direction;

E. Hold the two hand-held parts 2.3 in the longitudinal direction at the same time by hand, and stretch in the longitudinal direction to stretch the crepe sheet 1 in the longitudinal direction; remove the metal film layer 1.1 and finally obtain an expanded micro allograft skin sheet array, that is For the allogeneic skin graft 7 (Figure 16).

As shown in Fig. 16, the allogeneic skin sheet 6 is evenly spaced and distributed on the gauze layer 1.2 after being cut and expanded to form an allogeneic skin sheet 7 (such as a micro skin sheet 7), each of which has a positioning hole 7.1 at four corners.

The above-mentioned allogeneic skin patch 6 includes allogeneic skin patch and allogeneic skin patch; Allogeneic skin sheet, acellular allogeneic skin sheet or fresh allogeneic skin sheet; allogeneic skin sheet is selected from acellular dermal matrix pig skin sheet, acellular dermal matrix sheepskin sheet, acellular dermal matrix frog skin sheet and fresh pork rinds.

Example 3

The method for making a composite skin sheet as shown in Figure 16 includes the following steps:

i. First, the above-mentioned allogeneic skin flap 7 is laid on the dilator 2 through the allogeneic skin positioning hole 7.1;

ii. The above-mentioned autologous skin sheet 5 is then laid on the dilator 2 through the autologous skin positioning hole 5.1, and the adhesive surface of the adhesive layer of the autologous skin sheet 5 is bonded to the crepe sheet 2 of the allogeneic skin sheet 7 to make the foreign body. The skin patch 7 and the autologous skin patch 5 overlap;

iii. The autologous skin sheet 5 and the allogeneic skin sheet 7 are combined by the adhesive force of the adhesive layer to form an integral micro allogeneic skin sheet 7.1, and the micro allogeneic skin sheet 7.1 falls into the expanded autologous skin sheet 5 respectively. The autologous skin through hole 5.2 on the upper part; thus the autologous skin sheet 5 and the allogeneic skin sheet 7 are superimposed to form a composite skin sheet 8 .

The composite skin sheet 8 shown in Fig. 17 can be transplanted to the skin defect.

Other parts that are not described in detail are the prior art. Although the above embodiment has made a detailed description of the present invention, it is only a part of the embodiments of the present invention, rather than all the embodiments. People can also obtain other embodiments according to the present embodiment without creativity. These embodiments All belong to the protection scope of the present invention.

Claims (9)

1. A skin grafting tool, comprising a crepe sheet (1), the crepe sheet (1) comprising a lower metal film layer (1.1) and an upper gauze layer (1.2) stacked together, characterized in that: The crepe sheet (1) is arranged above the expander (2); the crepe sheet (1) is provided with a plurality of transverse folds (1.4) and a plurality of longitudinal folds (1.5); the longitudinal folds (1.5) are integral crepe yarns The pleats of the sheet (1), the transverse pleats being the pleats that fold the crepe sheet (2) together with the longitudinal pleats (1.5). 2. The skin grafting tool according to claim 1, characterized in that: the entire surface of the gauze layer (1.2) or the contact surface with the metal film layer (1.1) is sprayed with adhesive, so that the gauze layer (1.2) is connected to the metal film layer (1.2). An adhesive layer (1.3) is formed between the film layers (1.1); a plurality of rows of through holes (1.6) are formed on the crepe sheet (1) at horizontal and vertical intervals. 3. The skin grafting tool according to claim 2, characterized in that: the adhesive layer (1.3) is composed of adhesive tapes (1.31) arranged in parallel and at intervals; the through hole (1.6) is a square through hole , and the adhesive tape (1.31) is arranged between two rows of square through holes (1.6); the fold lines (1.7) of the transverse folds (1.4) and the longitudinal folds (1.5) are respectively in each row of square through holes (1.6) Coincidence with the centerline of each column of square through holes (1.6). 4. The skin grafting tool according to claim 1, characterized in that: the expander (2) is formed by two L-shaped brackets (2.1) intersecting each other to form a square frame, and four corners of the expander (2) are provided with positioning Column (2.2). 5. The skin grafting tool according to claim 4, characterized in that: four corners of the crepe sheet (1) are provided with positioning holes (1.7), and the positioning holes (1.7) are sleeved on the positioning posts (2.2) so as to The crepe sheet (1) is placed on the expander (2). 6. The skin grafting tool according to claim 1, characterized in that a hand-held part (2.3) is provided on the frame of the expander (2). 7. The skin grafting tool according to claim 1, characterized in that: the material of the metal film layer (1.1) is an aluminum foil layer, the material of the gauze layer (1.2) is polyamide double pleated yarn; the crepe sheet is In (1), the unfolded length of each transverse fold (1.4) is the same, and the unfolded length of each longitudinal fold (1.5) is the same. 8. a method of making composite skin sheet, is characterized in that: comprise the following steps: 1) The production of autologous skin grafts: a. Take an autologous skin piece the size of a cork tray by a peeling machine, stick the dermis layer of the autologous skin piece down on the cork tray, cut it vertically and horizontally with a peeling machine, and divide the autologous skin piece into N pieces of micro-autologous skin. , spray glue on the epidermis of the autologous skin piece attached to the cork plate, and then stick the epidermis surface of the skin piece on the gauze layer; b. Remove the cork tray; c. Position the crepe sheet with the skin sheet on the dilator, Wherein, the crepe sheet includes a lower metal film layer and an upper gauze layer that are stacked together, and the crepe sheet is arranged above the dilator; the crepe sheet is provided with a plurality of transverse folds and a plurality of longitudinal folds; the The longitudinal wrinkle is the wrinkle of the whole crepe sheet, and the transverse wrinkle is the wrinkle that folds the crepe sheet together with the longitudinal wrinkle; An adhesive layer is formed between the film layers; and the adhesive layer is composed of adhesive tapes arranged at intervals and in parallel horizontally; the crepe sheet is provided with multiple rows of through holes at horizontal and vertical intervals; and the adhesive tape is provided with two rows of square through holes. the center lines of each row of square through holes and each column of square through holes respectively overlap; d. Hold the two hand-held parts in the transverse direction at the same time by hand, and stretch in the transverse direction, so as to stretch the crepe sheet in the transverse direction; e. Hold the two hand-held parts in the longitudinal direction at the same time by hand, stretch in the longitudinal direction to stretch the crepe sheet in the longitudinal direction; remove the metal film layer and finally obtain an expanded autologous microskin array, which is the autologous skin and multiple rows of autologous skin through-holes are formed at horizontal and vertical intervals on the autologous skin sheet; 2) Production of allogeneic skin grafts: A. Take the allogeneic skin piece corresponding to the size of the cork plate by the peeling machine, stick it on the cork plate of the same size, cut it vertically and horizontally with the peeling machine, and divide the skin piece into N pieces of micro allogeneic skin pieces. Spray glue on the epidermis of the allogeneic skin piece attached to the cork plate, and then stick the skin surface of the allograft skin piece on the gauze layer. layer; B. Remove the cork tray; C. Position the crepe sheet with the skin sheet on the dilator, The crepe sheet includes a lower metal film layer and an upper gauze layer that are stacked together, the crepe sheet includes a lower metal film layer and an upper gauze layer that are stacked together, and the crepe sheet is disposed above the dilator; The crepe sheet is provided with a plurality of transverse pleats and a plurality of longitudinal pleats; the longitudinal pleats are pleats of the whole crepe sheet, and the transverse pleats are pleats obtained by folding the crepe sheet together with the longitudinal pleats; D. Hold the two hand-held parts in the transverse direction with the hands at the same time, and stretch in the transverse direction, thereby extending the crepe sheet 1 in the transverse direction; E. Hold the two hand-held parts in the longitudinal direction at the same time by hand, and stretch in the longitudinal direction to stretch the crepe sheet in the longitudinal direction; remove the metal film layer and finally get the expanded micro allograft skin sheet array, which is the allograft skin skin; 3) Production of composite skin sheet: i. First, the above-mentioned allogeneic skin sheet is laid on the dilator through the allogeneic skin positioning hole; ii. Then the above-mentioned autologous skin sheet is laid on the dilator through the autologous skin positioning hole, and the glue surface of the adhesive layer of the autologous skin sheet is bonded with the crepe sheet of the allogeneic skin sheet to make the allogeneic skin sheet and the autologous skin sheet. skin overlap; iii. The autologous skin sheet and the allogeneic skin sheet are combined by the adhesive force of the adhesive layer to form a whole micro allogeneic skin sheet, and the micro allogeneic skin sheet respectively falls into the autologous skin through holes on the expanded autologous skin sheet ; So the autologous skin sheet and the allogeneic skin sheet are superimposed to form a composite skin sheet. 9. the method for making composite skin sheet according to claim 1 is characterized in that: The allografts are selected from glycerol-preserved allografts, deep-low temperature refrigerator-preserved allografts, liquid nitrogen-preserved allografts, acellular allografts and fresh allografts. Allogeneic skin graft; The xenogeneic skin sheet is selected from acellular dermal matrix pigskin sheet, acellular dermal matrix sheepskin sheet, acellular dermal matrix frog skin sheet and fresh pig skin sheet.

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