CN110841001A - 一种集护脾益肺、行气化痰的莱菔子咀嚼片 - Google Patents
一种集护脾益肺、行气化痰的莱菔子咀嚼片 Download PDFInfo
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- CN110841001A CN110841001A CN201911336840.4A CN201911336840A CN110841001A CN 110841001 A CN110841001 A CN 110841001A CN 201911336840 A CN201911336840 A CN 201911336840A CN 110841001 A CN110841001 A CN 110841001A
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- Medicinal Preparation (AREA)
Abstract
本发明公开了一种集护脾益肺、行气化痰的莱菔子咀嚼片，对清热解毒，呕吐反胃，痰黏、脾胃虚弱、食欲不振等症有治疗作用，同时具有保健、护脾益肺、降气化痰等优点。
Description
技术领域：
本发明涉及食品保健领域，具体涉及一种集护脾益肺、行气化痰的莱菔子咀嚼片。
背景技术：
中医认为人体是由气、血及津液这些精微物质所組成，這些物质与身体各部相互作用及影响，以维持正常的生命活动。
痰是人体呼吸道的分泌物，它是通过支气管纤毛运动上皮纤毛的运动，从肺部向上呼吸道推动，最后，通过人的正常咳嗽反射从气管内咳出排出体外，正常人痰很少，只是保持呼吸道湿润而分泌的少量粘液。但当人吸入刺激性气体、尘埃、致病细菌、病毒等有害微生物时，上呼吸道就可能发生炎症，或者肺部发生疾病，呼吸道就会分泌增加，痰量就会增加，而痰的性质也会发生变化，可以由粘痰变成黄脓痰。比如：在支气管扩张症，肺结核空洞形成时，肺化脓性炎症时，黄脓痰的量就会增加，而且里面可以含大量的致病菌。呼吸道分泌少量的粘液是正常的，它对人可以起一个保护作用。当人吸入比较冷和干燥的空气时，通过呼吸道可以使进入肺内的含氧空气进行湿润和加温，也可以使吸入空气中的尘埃、有毒的其他颗粒以及空气中的含细菌的尘埃颗粒吸附在湿润的支气管壁上，通过支气管上皮的纤毛运动，推向上呼吸道，通过咳嗽排出体外，起到了保护肺脏的作用。
中医认为，痰的产生主要与肺、脾两脏有关。肺主呼吸，调节宗气(元气)的出入和升降。如肺失肃降，就可出现咳喘、卧不平等症。在风邪或寒邪侵肺时，使肺内的津液凝聚成痰。脾主运化，即消化和运送营养物质至各脏器。如果湿邪侵犯人体，或思虑过度、劳倦及饮食不节，都能伤脾而使其失去运化功能，造成水湿内停凝结成痰。
咀嚼片是一种服用方便，疗效显著的制剂。与一般片剂相比，咀嚼片口感良好、崩解时间短、分散状态佳、药物溶出迅速；药片经咀嚼后表面积增大，可促进药物在体内的溶解和吸收，故其生物利用度高。咀嚼片制备工艺较为简单，既很好地抑制了药物的苦味，又能便于患者轻松吞下，特别适合小儿、老人及吞咽困难的患者服用。因此需要一种集护脾益肺、行气化痰的莱菔子咀嚼片。
发明内容：
本发明的目的在于提供一种集护脾益肺、行气化痰的莱菔子咀嚼片。
本发明目的是通过以下技术方案实现的，一种集护脾益肺、行气化痰的莱菔子咀嚼片，是由原料按下述重量份数配比加工制作成的，莱菔子15-45份、白梅花10-35份、茶子10-30份、橙皮15-35份、匙叶草10-20份、大肺筋草10-30份、栀子叶10-25份、地骷髅10-25份、鹅蛋壳15-30份、骨节草10-30份、积雪草10-30份、果上叶10-25份、山梨醇5-15份，甜菊素0.1-1份、蒸馏水0.1-1份、二氧化硅0.05-0.5份。
一种集护脾益肺、行气化痰的莱菔子咀嚼片，是由原料按下述优选重量份数配比加工制作成的，莱菔子20-30份、白梅花20-35份、茶子15-25份、橙皮15-30份、匙叶草10-15份、大肺筋草10-25份、栀子叶10-20份、地骷髅10-20份、鹅蛋壳15-20份、骨节草15-25份、积雪草10-20份、果上叶15-25份、山梨醇5-10份，甜菊素0.1-0.5份、蒸馏水0.1-0.5份、二氧化硅0.05-0.1份。
一种集护脾益肺、行气化痰的莱菔子咀嚼片，是由原料按下述优选重量份数配比加工制作成的，莱菔子30份、白梅花35份、茶子20份、橙皮25份、匙叶草15份、大肺筋草10份、栀子叶20份、地骷髅15份、鹅蛋壳15份、骨节草25份、积雪草20份、果上叶15份、山梨醇5份，甜菊素0.1份、蒸馏水0.1份、二氧化硅0.05份。
一种集护脾益肺、行气化痰的莱菔子咀嚼片的其制备方法包括：
步骤1、备料：按上述重量份数比选取优质的莱菔子、白梅花、茶子、橙皮、匙叶草、大肺筋草、栀子叶、地骷髅、鹅蛋壳、骨节草、积雪草、果上叶洗净并除杂；
步骤2、提取：莱菔子、白梅花、茶子、橙皮干燥和粉碎后得到混合粉末；将混合粉末以亚临界水为提取液进行亚临界水提取，液料比为30mL/g-50mL/g，提取压力为1MPa-3MPa，提取温度为150℃-200℃，提取时间为20min-40min；得到的提取物经浓缩干燥、冻干，得到混合提取物粉末；按重量份数，将匙叶草、大肺筋草、栀子叶、地骷髅、鹅蛋壳、骨节草、积雪草、果上叶加水煮沸后，于100℃温浸二次，每次2小时，合并温浸液，滤过，滤液静置3小时，将得到澄清液浓缩至相对密度约1.3-1.5的清膏，最后在80℃减压干燥，得中药提取物；
步骤3、制剂：将混合提取物粉末、中药提取物粉碎成细粉，过100目筛，然后加入山梨醇、甜菊素混合均匀，加入蒸馏水，采用流化床制粒技术制粒或用摇摆制粒机制得整粒后，加入二氧化硅混合均匀，用压片机压片，制成片剂；
步骤4、包装：按照片剂规格，分类包装，制成成品。
在药物与配方中：莱菔子性平、味辛、甘，归肺、脾、胃经，有消食除胀、降气化痰的功效，用于饮食停滞、脘腹胀痛、大便秘结、积滞泻痢、痰壅喘咳；白梅花酸涩、平，入肝、肺二经，有舒肝、和胃、化痰的功效，治梅核气、肝胃气痛、食欲不振、头晕、瘰疬；茶子苦、寒，归肺经，降火消痰平喘，主痰热喘嗽、头脑鸣响；橙皮辛、苦、温，归脾、肺经，有理气、化痰、健脾、导滞的功效，主治感冒咳嗽、食欲不振、胸腹胀痛、肠鸣便泻、乳痈；匙叶草苦、微寒，归肺、肝、大肠经，有活血化瘀、清热止咳的功效，主腹内血瘀痞块、劳伤咳嗽；大肺筋草辛甘、平，归肺、肝经，有散风、清肺、化痰、行血的功效，主治愈冒、咳嗽、哮喘、经闭；栀子叶苦涩、寒，归肺、肝、肾经，有活血消肿、清热解毒的功效，主治跌打损伤、疔毒、痔疮、下疳；地骷髅甘辛、平，归肺、肾经，有宣肺化痰、消食、利水的功效，治咳嗽多痰、食积气滞、脘腹痞闷胀痛、水肿喘满、噤口痢疾；鹅蛋壳甘、淡、平，归肺经，有拔毒排脓、理气止痛的功效；骨节草平、甘、微苦，归肝、肺经，有疏风、明目、活血、止痛的功效，主迎风流泪、翳膜遮睛、跌打损伤、风湿痛；积雪草苦辛、寒，归肝、脾、肾经，清热利湿、解毒消肿的功效，主治用于湿热黄疸、中暑腹泻、砂淋血淋、痈肿疮毒、跌扑损伤；果上叶甘淡、凉，归肺、肝、肾经，有润肺化痰、行气止痛的功效，主治肺结核、咯血、慢性气管炎、慢性咽炎、疝气疼痛、月经不调、骨折。
有益效果：本发明提供一种集护脾益肺、行气化痰的莱菔子咀嚼片，对清热解毒，呕吐反胃，痰黏、脾胃虚弱、食欲不振等症有治疗作用，同时具有保健、护脾益肺、降气化痰等优点。
具体实施方式
下面结合具体实施例对本发明作进一步的说明：
实施例1：一种集护脾益肺、行气化痰的莱菔子咀嚼片，是由原料按下述重量份数配比加工制作成的，莱菔子15-45份、白梅花10-35份、茶子10-30份、橙皮15-35份、匙叶草10-20份、大肺筋草10-30份、栀子叶10-25份、地骷髅10-25份、鹅蛋壳15-30份、骨节草10-30份、积雪草10-30份、果上叶10-25份、山梨醇5-15份，甜菊素0.1-1份、蒸馏水0.1-1份、二氧化硅0.05-0.5份。
一种集护脾益肺、行气化痰的莱菔子咀嚼片的其制备方法包括：
步骤1、备料：按上述重量份数比选取优质的莱菔子、白梅花、茶子、橙皮、匙叶草、大肺筋草、栀子叶、地骷髅、鹅蛋壳、骨节草、积雪草、果上叶洗净并除杂；
步骤2、提取：莱菔子、白梅花、茶子、橙皮干燥和粉碎后得到混合粉末；将混合粉末以亚临界水为提取液进行亚临界水提取，液料比为30mL/g-50mL/g，提取压力为1MPa-3MPa，提取温度为150℃-200℃，提取时间为20min-40min；得到的提取物经浓缩干燥、冻干，得到混合提取物粉末；按重量份数，将匙叶草、大肺筋草、栀子叶、地骷髅、鹅蛋壳、骨节草、积雪草、果上叶加水煮沸后，于100℃温浸二次，每次2小时，合并温浸液，滤过，滤液静置3小时，将得到澄清液浓缩至相对密度约1.3-1.5的清膏，最后在80℃减压干燥，得中药提取物；
步骤3、制剂：将混合提取物粉末、中药提取物粉碎成细粉，过100目筛，然后加入山梨醇、甜菊素混合均匀，加入蒸馏水，采用流化床制粒技术制粒或用摇摆制粒机制得整粒后，加入二氧化硅混合均匀，用压片机压片，制成片剂；
步骤4、包装：按照片剂规格，分类包装，制成成品。
实施例2一种集护脾益肺、行气化痰的莱菔子咀嚼片，是由原料按下述优选重量份数配比加工制作成的，莱菔子20-30份、白梅花20-35份、茶子15-25份、橙皮15-30份、匙叶草10-15份、大肺筋草10-25份、栀子叶10-20份、地骷髅10-20份、鹅蛋壳15-20份、骨节草15-25份、积雪草10-20份、果上叶15-25份、山梨醇5-10份，甜菊素0.1-0.5份、蒸馏水0.1-0.5份、二氧化硅0.05-0.1份。
一种集护脾益肺、行气化痰的莱菔子咀嚼片的其制备方法包括：
步骤1、备料：按上述重量份数比选取优质的莱菔子、白梅花、茶子、橙皮、匙叶草、大肺筋草、栀子叶、地骷髅、鹅蛋壳、骨节草、积雪草、果上叶洗净并除杂；
步骤2、提取：莱菔子、白梅花、茶子、橙皮干燥和粉碎后得到混合粉末；将混合粉末以亚临界水为提取液进行亚临界水提取，液料比为30mL/g，提取压力为1MPa，提取温度为150℃，提取时间为20min；得到的提取物经浓缩干燥、冻干，得到混合提取物粉末；按重量份数，将匙叶草、大肺筋草、栀子叶、地骷髅、鹅蛋壳、骨节草、积雪草、果上叶加水煮沸后，于100℃温浸二次，每次2小时，合并温浸液，滤过，滤液静置3小时，将得到澄清液浓缩至相对密度约1.5的清膏，最后在80℃减压干燥，得中药提取物；
步骤3、制剂：将混合提取物粉末、中药提取物粉碎成细粉，过100目筛，然后加入山梨醇、甜菊素混合均匀，加入蒸馏水，采用流化床制粒技术制粒或用摇摆制粒机制得整粒后，加入二氧化硅混合均匀，用压片机压片，制成片剂；
步骤4、包装：按照片剂规格，分类包装，制成成品。
实施例3
一种集护脾益肺、行气化痰的莱菔子咀嚼片，是由原料按下述优选重量份数配比加工制作成的，莱菔子30份、白梅花35份、茶子20份、橙皮25份、匙叶草15份、大肺筋草10份、栀子叶20份、地骷髅15份、鹅蛋壳15份、骨节草25份、积雪草20份、果上叶15份、山梨醇5份，甜菊素0.1份、蒸馏水0.1份、二氧化硅0.05份。
一种集护脾益肺、行气化痰的莱菔子咀嚼片的其制备方法包括：
步骤1、备料：按上述重量份数比选取优质的莱菔子、白梅花、茶子、橙皮、匙叶草、大肺筋草、栀子叶、地骷髅、鹅蛋壳、骨节草、积雪草、果上叶洗净并除杂；
步骤2、提取：莱菔子、白梅花、茶子、橙皮干燥和粉碎后得到混合粉末；将混合粉末以亚临界水为提取液进行亚临界水提取，液料比为40mL/g，提取压力为3MPa，提取温度为200℃，提取时间为30min；得到的提取物经浓缩干燥、冻干，得到混合提取物粉末；按重量份数，将匙叶草、大肺筋草、栀子叶、地骷髅、鹅蛋壳、骨节草、积雪草、果上叶加水煮沸后，于100℃温浸二次，每次2小时，合并温浸液，滤过，滤液静置3小时，将得到澄清液浓缩至相对密度约1.3的清膏，最后在80℃减压干燥，得中药提取物；
步骤3、制剂：将混合提取物粉末、中药提取物粉碎成细粉，过100目筛，然后加入山梨醇、甜菊素混合均匀，加入蒸馏水，采用流化床制粒技术制粒或用摇摆制粒机制得整粒后，加入二氧化硅混合均匀，用压片机压片，制成片剂；
步骤4、包装：按照片剂规格，分类包装，制成成品。
本发明药物的主要功能与治疗范围：
1、主要功能：
对黄痰，咳嗽，头痛，咽喉肿痛，呕吐反胃，痰黏等症不同程度上有疗效；
2、用法与用量
每天服用本发明一次，7天为一个疗程；
3、本发明药物的临床观察：
（1）临床症状
黄痰，咳嗽，头痛，咽喉肿痛，呕吐反胃，痰黏；
（2）一般资料
符合上述临床症状；年龄在22～70岁之间，男女不限； 2周内未使用与本病相关的外用药物，4周内未使用治疗本病的任何内服药物；重要脏器组织功能基本正常，符合本研究入选标准的患者为300例；知情同意者；
（3）排除标准：
对药物成分过敏者；合并有严重心脑血管疾病、肝肾及造血系统等原发性疾病以及精神病者；妊娠期或哺乳期妇女；
（4）剔除和中止标准：
①未按方案用药，影响有效性和安全性判断者；
②研究过程中自行退出者；
③资料不全，影响有效性和安全性判断者。
④治疗过程中，出现严重不良反应者。
4、 观察方法：
（1）病例分组：
采用随机、对照的方法，将入选病例随机分为治疗组和对照组2组，每组150人；
（2）治疗方法：
治疗组：每天服用本发明一次，7天为一个疗程；对照组：服用专利为CN201210572734.8一种治疗感冒的中药制剂，7天为一个疗程；
（3）记录情况：每周观察一次，及时记患者变化情况。
表1使用前后两组疗程比较(单位：人)
治疗组和对照组有显著差异，从而可以看出本发明在临床上的应用有显著的疗效。
二、长期毒性试验
以本发明实施例3制得的咀嚼片为试验，采用灌胃给药方式，将本发明中药分为低剂量、中剂量、高剂量三组，各组的药物用量分别为10、30、50g生药/kg/d，相当于临床剂量的10、30、50倍。灌胃给药24周后，本发明中药对动物的一般状况、血液学指标、血液生化指标均无明显的影响，系统解剖、脏器系数及组织病理学检查也未发现异常病理改变。停药2周也未见明显改变。结果表明：本发明中药在长期毒性试验中，未发现明显毒性反应和延迟毒性反应。可见，本发明中药无毒性反应，长期用药安全可靠。
Claims (4)
1.一种集护脾益肺、行气化痰的莱菔子咀嚼片，其特征在于：是由原料按下述重量份数配比加工制作成的，莱菔子15-45份、白梅花10-35份、茶子10-30份、橙皮15-35份、匙叶草10-20份、大肺筋草10-30份、栀子叶10-25份、地骷髅10-25份、鹅蛋壳15-30份、骨节草10-30份、积雪草10-30份、果上叶10-25份、山梨醇5-15份，甜菊素0.1-1份、蒸馏水0.1-1份、二氧化硅0.05-0.5份。
2.根据权利要求1所述的一种集护脾益肺、行气化痰的莱菔子咀嚼片，其特征在于：是由原料按下述优选重量份数配比加工制作成的，莱菔子20-30份、白梅花20-35份、茶子15-25份、橙皮15-30份、匙叶草10-15份、大肺筋草10-25份、栀子叶10-20份、地骷髅10-20份、鹅蛋壳15-20份、骨节草15-25份、积雪草10-20份、果上叶15-25份、山梨醇5-10份，甜菊素0.1-0.5份、蒸馏水0.1-0.5份、二氧化硅0.05-0.1份。
3.根据权利要求1所述的一种集护脾益肺、行气化痰的莱菔子咀嚼片，其特征在于：是由原料按下述优选重量份数配比加工制作成的，莱菔子30份、白梅花35份、茶子20份、橙皮25份、匙叶草15份、大肺筋草10份、栀子叶20份、地骷髅15份、鹅蛋壳15份、骨节草25份、积雪草20份、果上叶15份、山梨醇5份，甜菊素0.1份、蒸馏水0.1份、二氧化硅0.05份。
4.根据权利要求1-3任一项所述的一种集护脾益肺、行气化痰的莱菔子咀嚼片的其制备方法包括：
步骤1、备料：按上述重量份数比选取优质的莱菔子、白梅花、茶子、橙皮、匙叶草、大肺筋草、栀子叶、地骷髅、鹅蛋壳、骨节草、积雪草、果上叶洗净并除杂；
步骤2、提取：莱菔子、白梅花、茶子、橙皮干燥和粉碎后得到混合粉末；将混合粉末以亚临界水为提取液进行亚临界水提取，液料比为30mL/g-50mL/g，提取压力为1MPa-3MPa，提取温度为150℃-200℃，提取时间为20min-40min；得到的提取物经浓缩干燥、冻干，得到混合提取物粉末；按重量份数，将匙叶草、大肺筋草、栀子叶、地骷髅、鹅蛋壳、骨节草、积雪草、果上叶加水煮沸后，于100℃温浸二次，每次2小时，合并温浸液，滤过，滤液静置3小时，将得到澄清液浓缩至相对密度约1.3-1.5的清膏，最后在80℃减压干燥，得中药提取物；
步骤3、制剂：将混合提取物粉末、中药提取物粉碎成细粉，过100目筛，然后加入山梨醇、甜菊素混合均匀，加入蒸馏水，采用流化床制粒技术制粒或用摇摆制粒机制得整粒后，加入二氧化硅混合均匀，用压片机压片，制成片剂；
步骤4、包装：按照片剂规格，分类包装，制成成品。
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