CN110741263B - Liquid supply device, sample analyzer and liquid supply method - Google Patents
Liquid supply device, sample analyzer and liquid supply method Download PDFInfo
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- CN110741263B CN110741263B CN201880039306.4A CN201880039306A CN110741263B CN 110741263 B CN110741263 B CN 110741263B CN 201880039306 A CN201880039306 A CN 201880039306A CN 110741263 B CN110741263 B CN 110741263B
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- 239000007788 liquid Substances 0.000 title claims abstract description 765
- 238000000034 method Methods 0.000 title claims abstract description 44
- 239000012530 fluid Substances 0.000 claims description 88
- 239000003153 chemical reaction reagent Substances 0.000 claims description 51
- 238000001802 infusion Methods 0.000 claims description 20
- 238000006073 displacement reaction Methods 0.000 claims description 19
- 230000001502 supplementing effect Effects 0.000 claims description 15
- 238000002637 fluid replacement therapy Methods 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 6
- 238000004891 communication Methods 0.000 claims description 4
- 230000002950 deficient Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 description 32
- 238000001514 detection method Methods 0.000 description 18
- 238000006243 chemical reaction Methods 0.000 description 8
- 238000005265 energy consumption Methods 0.000 description 5
- 239000002699 waste material Substances 0.000 description 5
- 238000005070 sampling Methods 0.000 description 4
- 239000012472 biological sample Substances 0.000 description 3
- 210000000601 blood cell Anatomy 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 230000002457 bidirectional effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
A liquid supply device comprises a first liquid component (1), a first liquid storage pool (2) connected with the first liquid component (1) and a standby liquid storage component (3), wherein the first liquid storage pool (2) is used for supplying liquid for the first liquid component (1), and the standby liquid storage component (3) is used for supplying liquid for the first liquid component (1) when the liquid in the first liquid storage pool (2) is insufficient. The liquid supply device can continuously supply liquid. The invention also discloses a sample analyzer comprising the liquid supply device and a liquid supply method.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a liquid supply device, a sample analyzer and a liquid supply method.
Background
In the current blood cell analyzer, when the liquid in the liquid storage tank is consumed and needs to be replenished, the method generally adopted is to switch the pressure of the liquid storage tank into negative pressure, suck the liquid into the liquid storage tank by utilizing the pressure difference between the reagent barrel and the liquid storage tank, and switch the liquid storage tank into positive pressure after the liquid filling is completed so as to drain outwards. Therefore, in the process of replenishing the liquid in the liquid storage tank, the liquid cannot be continuously discharged outwards, so that a pipeline requiring the liquid in the blood cell analyzer is forced to stop working, and the working efficiency of the blood cell analyzer is reduced.
Disclosure of Invention
The invention aims to provide a liquid supply device capable of continuously supplying liquid, a sample analyzer and a liquid supply method.
In order to achieve the above object, the present invention adopts the following technical scheme:
in a first aspect, a liquid supply device is provided, including a first liquid component, and a first liquid storage tank and a standby liquid storage component connected with the first liquid component, wherein the first liquid storage tank is used for supplying liquid to the first liquid component, and the standby liquid storage component supplies liquid to the first liquid component when the liquid in the first liquid storage tank is insufficient.
The first liquid storage tank is connected with the standby liquid storage assembly and used for supplying liquid to the standby liquid storage assembly.
The first liquid storage pool is connected with the first liquid component, and the second liquid storage pool is connected with the second liquid component.
The first liquid storage pool is connected with the first liquid component, the second liquid storage pool is connected with the second liquid component, the first liquid storage pool is connected with the second liquid component, the second liquid storage pool is connected with the first liquid storage pool, the second liquid storage pool is connected with the second liquid component, and the first liquid storage pool is connected with the second liquid component.
Wherein, reserve stock solution subassembly includes syringe and drive arrangement of drive syringe.
The standby liquid storage assembly comprises a quantitative pump and a third switching piece, a liquid chamber of the quantitative pump is connected with the first liquid assembly, an air chamber of the quantitative pump is connected with the third switching piece, and when the air chamber is communicated with a first positive pressure source through the third switching piece, the first positive pressure source pushes liquid in the liquid chamber into the first liquid assembly.
The liquid supply device further comprises a fourth switching piece, the fourth switching piece is connected with the first liquid storage tank, the liquid chamber is connected with the first liquid storage tank, when the air chamber is communicated with the atmosphere or a first negative pressure source through the third switching piece, the first liquid storage tank is communicated with a second positive pressure source through the fourth switching piece, and the second positive pressure source pushes liquid in the first liquid storage tank into the liquid chamber.
The liquid supply device further comprises a reagent barrel connected with the first liquid storage tank, and when the first liquid storage tank is communicated with the second negative pressure source, liquid in the reagent barrel enters the first liquid storage tank under the action of pressure difference.
And a fifth switching piece is arranged between the first liquid storage pool and the reagent bucket and is used for communicating or cutting off the first liquid storage pool and the reagent bucket.
The liquid supply device further comprises a second liquid use component, a second liquid storage tank, a liquid supplementing component and a sixth switching piece, wherein the second liquid storage tank is connected with the second liquid use component and is used for supplying liquid to the second liquid use component, and the liquid supplementing component is connected with the second liquid storage tank and the reagent barrel through the sixth switching piece;
the sixth switching piece is used for communicating the fluid infusion assembly with the reagent bucket so that the fluid infusion assembly can extract liquid in the reagent bucket, or communicating the fluid infusion assembly with the second liquid storage pool so that the fluid infusion assembly can inject liquid in the fluid infusion assembly into the second liquid storage pool.
Wherein, the fluid infusion assembly comprises an injector or a fixed displacement pump.
The liquid supply device further comprises a pressure sensor and a seventh switching piece, wherein the pressure sensor is connected with the second liquid storage tank and is used for detecting a pressure value in the second liquid storage tank, and the second liquid storage tank is connected with the seventh switching piece;
when the pressure value is larger than a preset value, the seventh switching piece is communicated with the second liquid storage pool to the atmosphere or a third negative pressure source.
The seventh switching part is used for connecting an interface of the atmosphere or the third negative pressure source, and a flow limiting part is arranged at the interface and used for releasing partial pressure in the second liquid storage pool.
In a second aspect, there is further provided a liquid supply apparatus, including a second liquid-using component, a second liquid storage tank, a syringe, a sixth switching member, and a reagent tank, where the second liquid storage tank is connected to the second liquid-using component and is used for supplying liquid to the second liquid-using component, and the syringe is connected to the second liquid storage tank and the reagent tank through the sixth switching member;
the sixth switching piece is used for communicating the injector with the reagent bucket so that the injector can extract liquid in the reagent bucket, or communicating the injector with the second liquid storage pool so that the injector can inject the liquid in the injector into the second liquid storage pool.
In a third aspect, a sample analyzer is provided, including the above-described liquid supply device.
In a fourth aspect, there is also provided a liquid supply method, including:
filling a spare liquid in the spare liquid storage assembly;
the first liquid storage pool is used for supplying liquid for the first liquid component; and
the reserve liquid storage assembly supplies the reserve liquid to the first liquid assembly when the liquid in the first liquid storage pool is insufficient.
Wherein, the process of filling the spare liquid in the spare liquid storage component comprises the following steps:
and communicating the first liquid storage pool with the standby liquid storage assembly, wherein liquid in the first liquid storage pool enters the standby liquid storage assembly to form the standby liquid.
Wherein, reserve stock solution subassembly includes the constant displacement pump, the constant displacement pump includes liquid room and air chamber, the process of "filling reserve liquid in reserve stock solution subassembly" includes:
disconnecting the liquid chamber from the first liquid component and communicating the liquid chamber with the first liquid storage tank, wherein the air chamber is communicated with atmosphere or a first negative pressure source, the first liquid storage tank is communicated with a second positive pressure source, and the second positive pressure source pushes liquid in the first liquid storage tank into the liquid chamber.
Wherein the reserve liquid storage assembly comprises a dosing pump comprising a liquid chamber and a gas chamber, the process of the reserve liquid storage assembly supplying the reserve liquid to the first liquid assembly comprises:
the liquid chamber is communicated with the first liquid component, the air chamber is communicated with a first positive pressure source, and the first positive pressure source pushes the standby liquid in the liquid chamber into the first liquid component.
Wherein, the liquid supply method further comprises:
when the liquid in the first liquid storage pool is insufficient, the first liquid storage pool is disconnected from the first liquid assembly and communicated with the first liquid storage pool and the reagent bucket, and the first liquid storage pool is communicated to a second negative pressure source, so that the liquid in the reagent bucket enters the first liquid storage pool under the action of pressure difference.
Wherein, the liquid supply method further comprises:
the fluid replacement component extracts fluid replacement from the reagent barrel;
the second liquid storage pool is used for supplying liquid for the second liquid using component;
when the liquid in the second liquid storage pool is insufficient, the liquid supplementing assembly fills the supplementing liquid into the second liquid storage pool, so that the second liquid storage pool can continuously supply liquid for the second liquid using assembly.
Wherein, the liquid supply method further comprises:
the standby liquid storage assembly comprises a syringe and a driving device for driving the syringe, wherein the process of filling standby liquid in the standby liquid storage assembly comprises the steps of communicating the syringe with the first liquid storage pool, the first liquid storage pool is communicated with a second positive pressure source, and the driving device enables liquid in the first liquid storage pool to enter the syringe. Preferably, when the first reservoir is connected to the second positive pressure source, the driving device disconnects the syringe from the first liquid assembly before the liquid in the first reservoir enters the syringe. When the syringe is disconnected from the first liquid storage tank and the syringe is communicated with the first liquid component, the driving device pushes the standby liquid in the syringe into the first liquid component.
Compared with the prior art, the invention has the following beneficial effects:
When the liquid in the first liquid storage tank of the liquid supply device is enough, the liquid in the first liquid storage tank is supplied to the first liquid component, and when the liquid in the first liquid storage tank is insufficient, the standby liquid storage component can continuously supply liquid to the first liquid component, so that the liquid supply device can realize continuous liquid supply, and further the limitation of the detection speed of the sample analyzer caused by discontinuous liquid supply is avoided, and the detection speed of the sample analyzer is higher.
Drawings
In order to more clearly illustrate the technical solutions of the present invention, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained by those skilled in the art without the inventive effort.
Fig. 1 is a schematic diagram of a liquid supply device according to an embodiment of the present invention.
Fig. 2 is a schematic view of a liquid supply apparatus according to another embodiment of the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1, an embodiment of the present invention provides a sample analyzer. The sample analyzer may be used to perform biological sample analysis, which may be blood, urine, etc. The sample analyzer includes a liquid supply 100.
The sample analyzer comprises a driving component, a sampling component, a reaction component, a detection component, a waste liquid treatment component and a controller. The drive assembly is used to drive various flow paths (including gas and liquid paths) in the sample analyzer. The driving assembly comprises a plurality of air tanks and an air pump, wherein the air pump respectively establishes positive pressure and negative pressure in the air tanks, and the positive pressure and the negative pressure are used for realizing driving. The sampling assembly is used for collecting and distributing biological samples. The sampling assembly includes a sampling needle. The reaction component is used for processing the biological sample to form a liquid to be tested. The reaction assembly includes a plurality of reaction cells. The detection component is used for detecting the liquid to be detected to form detection information. The detection assembly includes a flow chamber. The waste liquid treatment assembly is used for collecting and discharging waste liquid in the sample analyzer. The controller is configured to control a workflow of the sample analyzer and process the detection information to form an analysis result.
Referring to fig. 1, an embodiment of the present invention provides a liquid supply apparatus 100, where the liquid supply apparatus 100 includes a first liquid component 1, and a first liquid storage tank 2 and a standby liquid storage component 3 connected to the first liquid component 1. The first liquid storage tank 2 is used for supplying liquid to the first liquid component 1, and the standby liquid storage component 3 is used for supplying liquid to the first liquid component 1 when the liquid in the first liquid storage tank 2 is insufficient.
In this embodiment, when the liquid in the first liquid storage tank 2 is sufficient, the liquid in the first liquid storage tank 2 is supplied to the first liquid component 1, and when the liquid in the first liquid storage tank 2 is insufficient, the spare liquid storage component 3 can continuously supply the liquid to the first liquid component 1, so that the liquid supply device 100 can realize continuous liquid supply, thereby avoiding the limitation of the detection speed of the sample analyzer due to discontinuous liquid supply, and the detection speed of the sample analyzer is faster.
It can be appreciated that when the spare liquid storage component 3 supplies liquid to the first liquid storage component 1, the liquid can be poured into the first liquid storage tank 2, so that the liquid in the first liquid storage tank 2 is enough, and the subsequent continuous liquid supply to the first liquid storage component 1 is facilitated, thereby improving the detection speed of the sample analyzer.
Alternatively, the first liquid component 1 may be the reaction component or the detection component. For example, the first liquid component 1 may be a reaction tank. The first reservoir 2 may be used for storing a diluent.
Optionally, a first liquid level sensor is disposed in the first liquid storage tank 2, and is used for detecting the liquid level in the first liquid storage tank 2. The first level sensor may be a float sensor.
As an alternative embodiment, the first liquid storage tank 2 is connected to the spare liquid storage assembly 3, and is used for supplying liquid to the spare liquid storage assembly 3. The first liquid storage tank 2 may supply the liquid to the spare liquid storage assembly 3 before the first liquid storage assembly 1 supplies the liquid, so that enough liquid is in the spare liquid storage assembly 3, and the spare liquid storage assembly 3 can supply the liquid to the first liquid storage assembly 1 when the liquid in the first liquid storage tank 2 is insufficient.
As an alternative embodiment, a first switching element 41 and a second switching element 42 are arranged between the first reservoir 2 and the first liquid assembly 1. The standby liquid storage assembly 3 is connected between the first switching member 41 and the second switching member 42. The spare liquid storage assembly 3 is connected with the first liquid storage pool 2 through the first switching piece 41. The standby liquid storage component 3 is connected with the first liquid component 1 through the second switching piece 42. The first switching member 41 is used for making communication or cutting off, and the second switching member 42 is used for making communication or cutting off.
In this embodiment, the second switching member 42 cuts off the first liquid storage tank 2 and the spare liquid storage tank 3 of the first liquid assembly 1, and the first liquid storage tank 2 supplies liquid to the spare liquid storage tank 3 when the first switching member 41 communicates the first liquid storage tank 2 and the spare liquid storage tank 3. When the first switching member 41 and the second switching member 42 are connected to the first liquid storage tank 2 and the first liquid assembly 1, the first liquid storage tank 2 supplies liquid to the first liquid assembly 1. The first switching member 41 cuts off the first liquid storage tank 2 from the first liquid assembly 1 and the spare liquid storage assembly 3, and the second switching member 42 is configured to supply liquid to the first liquid assembly 1 when the spare liquid storage assembly 3 is communicated with the first liquid assembly 1, the spare liquid storage assembly 3 is connected with the spare liquid assembly 3.
Optionally, a three-way member 43 is disposed between the first switching member 41 and the second switching member 42, and the three-way member 43 is connected to the first switching member 41, the second switching member 42, and the spare liquid storage assembly 3. The first switching member 41 may be a shut-off valve. The second switching member 42 may be a shut-off valve.
As an alternative embodiment, the backup liquid storage assembly 3 includes a dosing pump 31 and a third switching member 32. The liquid chamber 311 of the fixed displacement pump 31 is connected to the first liquid component 1, and the air chamber 312 of the fixed displacement pump 31 is connected to the third switching member 32. When the air chamber 312 communicates with the first positive pressure source 51 through the third switching member 32, the first positive pressure source 51 pushes the liquid in the liquid chamber 311 into the first liquid component 1. The third switch 32 may be a single two-position three-way solenoid valve or two shut-off valves.
Optionally, the liquid supply device 100 further includes a fourth switching member 44, and the fourth switching member 44 is connected to the first liquid storage tank 2. The liquid chamber 311 is connected to the first liquid storage tank 2. When the air chamber 312 of the dosing pump 31 is communicated with the atmosphere or the first negative pressure source 52 through the third switching member 32, the first liquid storage tank 2 is communicated with the second positive pressure source 53 through the fourth switching member 44, and the second positive pressure source 53 pushes the liquid in the first liquid storage tank 2 into the liquid chamber 311. The fourth switching member 44 may be a single two-position three-way solenoid valve or two shut-off valves.
In the present embodiment, the third switching member 32 is configured to communicate the air chamber 312 to the first positive pressure source 51, or communicate the air chamber 312 to the atmosphere or the first negative pressure source 52. Since the air chamber 312 is connected to the atmosphere or the first negative pressure source 52 (the flow rate of the first negative pressure source 52 is smaller than the flow rate of the first positive pressure source 51), and the liquid chamber 311 is connected to the second positive pressure source 53 through the first liquid reservoir 2, the second positive pressure source 53 pushes the internal diaphragm of the fixed displacement pump 31 toward the air chamber 312 to push the liquid in the first liquid reservoir 2 into the liquid chamber 311, so that the fixed displacement pump 31 is mainly driven with positive pressure for filling. Since the first positive pressure source 51 pushes the diaphragm inside the fixed displacement pump 31 toward the liquid chamber 311 when the liquid chamber 311 is connected to the first liquid component 1 and the air chamber 312 is connected to the first positive pressure source 51, so that the liquid in the liquid chamber 311 is pushed into the first liquid component 1, the fixed displacement pump 31 is mainly driven by positive pressure to supply liquid. Therefore, the constant delivery pump 31 adopts a bidirectional positive pressure driving mode, so that the driving difficulty is low, and the energy consumption of the sample analyzer is saved.
It can be understood that, the first negative pressure source 52 plays a role of auxiliary driving, the working state of the fixed displacement pump 31 is hardly affected even if the stability and the pressure-building accuracy of the first negative pressure source 52 are insufficient, the fixed displacement pump 31 can still maintain a stable working state, and the liquid supply state of the liquid supply device 100 is stable.
It is to be understood that the dosing pump 31 may not use the first negative pressure source 52, that is, the air chamber 312 may be connected to the first positive pressure source 51 or the atmosphere through the third switching member 32. The sample analyzer can realize accurate control of the positive pressure environment, so that the action of the quantitative pump 31 can be controlled stably, and unstable filling or liquid supply of the quantitative pump 31 caused by unstable negative pressure environment can be avoided.
In another embodiment, the reserve fluid reservoir assembly 3 may also comprise a syringe. Before the first liquid storage pool 2 supplies the liquid for the first liquid component 1, the injector firstly draws the liquid in the first liquid storage pool 2, so that the injector has enough liquid. When the liquid in the first liquid storage tank 2 is insufficient, the injector pushes the liquid in the first liquid storage tank into the first liquid component 1. Specifically, referring to fig. 2, the three-way member 43 connects the first switching member 41, the second switching member 42, and the reserve tank assembly 3 includes a syringe and a driving device, such as a motor, for driving the syringe. In the case where continuous supply of the first liquid component 1 is required, when the first liquid storage tank 2 is connected to the second positive pressure source 53 through the fourth switching member 44, liquid is supplied to the first liquid component 1, and at the same time, the syringe 3 is controlled to suck liquid, so that enough liquid exists in the syringe; alternatively, when the first liquid storage tank 2 is connected to the second positive pressure source 53 through the fourth switching member 44, the second switching member 42 cuts off the first liquid component 1, the first liquid storage tank 2 and the spare liquid storage component 3, and the first switching member 41 communicates the first liquid storage tank 2 and the spare liquid storage component 3, and controls the syringe 3 to absorb liquid, so that sufficient liquid exists in the syringe. When the first liquid storage pool 2 needs to be filled, the fourth switching piece 44 is switched to negative pressure for filling, at the moment, the first switching piece 41 is electrified, the channel is closed, the injector is controlled to push up to push the liquid in the first liquid assembly 1, and continuous liquid supply is realized. In this embodiment, the second switching member 42 may be omitted, and since the injector is driven by the motor, the stopper rod in the injector is ensured to be in a stable and controllable state, the liquid in the injector is maintained stable, and the influence of the liquid fluctuation in the pipeline on the liquid level in the first liquid component 1 is avoided, thereby ensuring the accuracy of the reaction and measurement. When the fixed displacement pump is used as the spare liquid storage component, the second switching piece 42 is preferably used, and when the first liquid storage 2 is supplied to the fixed displacement pump, the second switching piece 42 is cut off, so that the influence of the vibration of the diaphragm in the fixed displacement pump on the liquid level in the first liquid component 1 can be avoided.
As an alternative embodiment, the liquid supply device 100 further comprises a reagent vessel 6 connected to the first liquid reservoir 2. When the first liquid storage tank 2 is connected to the second negative pressure source 54, the liquid in the reagent bucket 6 enters the first liquid storage tank 2 under the action of pressure difference. When the first liquid storage pool 2 is supplied with liquid, the internal pressure is positive pressure. When the first liquid storage pool 2 is filled, the internal pressure is negative pressure.
Optionally, a fifth switching member 45 is disposed between the first liquid storage tank 2 and the reagent bucket 6, and the fifth switching member 45 is used for communicating or cutting off the first liquid storage tank 2 and the reagent bucket 6. The fifth switching member 45 may be a shut-off valve.
In one embodiment, the spare reservoir assembly 3 may also be connected to the reagent tank 6, and the reagent tank 6 is further used to supply the spare reservoir assembly 3 with liquid.
As an alternative embodiment, the liquid supply apparatus 100 further includes a second liquid using assembly 7, a second liquid storage tank 8, a liquid supplementing assembly 9, and a sixth switching member 46. The second liquid storage pool 8 is connected with the second liquid using assembly 7 and is used for supplying liquid to the second liquid using assembly 7. The fluid infusion assembly 9 is connected to the second reservoir 8 and the reagent vessel 6 via the sixth switch 46. The sixth switching member 46 is configured to communicate the fluid infusion assembly 9 with the reagent tank 6 to enable the fluid infusion assembly 9 to draw the liquid in the reagent tank 6, or communicate the fluid infusion assembly 9 with the second liquid storage tank 8 to enable the fluid infusion assembly 9 to inject the liquid in the fluid infusion assembly 9 into the second liquid storage tank 8. The sixth switch 46 may be a single two-position three-way solenoid valve or two shut-off valves.
In this embodiment, when the liquid in the second liquid storage tank 8 is sufficient, the second liquid storage tank 8 supplies the liquid to the second liquid using assembly 7. At this time, the fluid replacement assembly 9 may communicate with the reagent vessel 6 through the sixth switching member 46, thereby extracting the fluid from the reagent vessel 6. When the liquid in the second liquid storage tank 8 is insufficient, the liquid supplementing component 9 is communicated with the second liquid storage tank 8 through the sixth switching piece 46, the liquid in the liquid supplementing component 9 is injected into the second liquid storage tank 8 by the liquid supplementing component 9 so as to supplement the liquid in the second liquid storage tank 8, so that the second liquid storage tank 8 can continuously supply liquid for the second liquid using component 7, and therefore continuous liquid supply can be realized for the second liquid storage tank 8, and the detection speed of the sample analyzer is limited due to discontinuous liquid supply, and is relatively high. The fluid infusion assembly 9 can maintain the pressure in the second fluid reservoir 8 when the second fluid reservoir 8 is infused, so that the second fluid reservoir 8 can normally feed fluid. Since the second liquid storage tank 8 can realize continuous liquid supply without switching the internal pressure, the gas consumption of the sample analyzer can be reduced, and the energy consumption of the sample analyzer can be reduced.
Alternatively, the second liquid component 7 may be the reaction component or the detection component. For example, the second liquid component 7 may be a flow chamber. The second reservoir 8 may be used to store sheath fluid.
Optionally, a second liquid level sensor is disposed in the second liquid storage tank 8, and is used for detecting the liquid level in the second liquid storage tank 8. The second level sensor may be a float sensor.
Optionally, the fluid infusion assembly 9 includes a syringe or a dosing pump. Of course, in other embodiments, the fluid infusion assembly 9 may also include other devices that can achieve a metered addition.
Optionally, the liquid supply apparatus 100 further includes a pressure sensor 81 and a seventh switching member 82. The pressure sensor 81 is connected to the second liquid storage tank 8, and is used for detecting a pressure value in the second liquid storage tank 8. The second liquid reservoir 8 is connected to the seventh switching element 82. When the pressure value is greater than a preset value, the seventh switching member 82 communicates the second liquid storage tank 8 to the atmosphere or the third negative pressure source 55. When the pressure value is equal to or less than the threshold value, the seventh switching member 82 communicates the second reservoir 8 to the third positive pressure source 56. The seventh switching member 82 may be a single two-position three-way solenoid valve or two shut-off valves.
In this embodiment, the pressure sensor 81 continuously detects the pressure in the second liquid reservoir 8. When the fluid replacement assembly 9 fills the second fluid reservoir 8, the pressure in the second fluid reservoir 8 may rise. If the pressure value in the second liquid storage tank 8 is greater than the preset value, the pressure in the second liquid storage tank 8 is higher than the normal working range, and the seventh switching member 82 is used for communicating the second liquid storage tank 8 to the atmosphere or the third negative pressure source 55, so as to release part of the pressure in the second liquid storage tank 8, so that the pressure value is reduced to be within the normal working range, and the second liquid storage tank 8 can be ensured to be supplied normally. In the process of supplying the second liquid storage tank 8, if the pressure value of the pressure in the second liquid storage tank 8 is smaller than or equal to the threshold value and is lower than the normal working range, the seventh switching member 82 is used for communicating the second liquid storage tank 8 to the third positive pressure source 56, so that the third positive pressure source 56 builds up pressure in the second liquid storage tank 8, and the pressure value is raised to be within the normal working range, thereby ensuring that the second liquid storage tank 8 can normally supply liquid. In short, the liquid supply device 100 can control the pressure value of the pressure in the second liquid storage tank 8, so that the pressure value is kept in a normal working range, thereby ensuring that the second liquid storage tank 8 can supply liquid normally.
It will be appreciated that the supply pressure of the second reservoir 8 may be adjusted by setting the preset value and the threshold value, so as to meet different supply demands.
In other embodiments, a pressure valve may be provided on the second reservoir 8, whereby the pressure value of the pressure in the second reservoir 8 is controlled within a normal operating range by the pressure valve. Of course, in other embodiments, the pressure valve may be replaced with other mechanical or electronic structures to maintain the pressure of the second reservoir 8 within a specified range.
Optionally, a flow restrictor 83 is provided at the interface of the seventh switching element 82 for connecting to the atmosphere or the third negative pressure source 55, and the flow restrictor 83 is used for releasing part of the pressure in the second liquid reservoir 8. The restrictor 83 is configured to slowly and stably release the pressure in the second liquid storage tank 8, so as to avoid waste of air volume caused by release of excessive pressure in the second liquid storage tank 8 (if the pressure in the second liquid storage tank 8 is released too much, the third positive pressure source 56 is required to raise the pressure in the second liquid storage tank 8, and waste of air volume of the liquid supply device 100).
Optionally, an eighth switching element 47 is disposed between the second liquid storage tank 8 and the second liquid using assembly 7. The eighth switching member 47 is configured to connect or disconnect the second liquid storage tank 8 to the second liquid use module 7. The eighth switching member 47 may be a shut-off valve.
It will be appreciated that in the embodiment of the present invention, the pouring and supplying actions of the first and second liquid reservoirs 2 and 8 are achieved by precisely controlling the consumption of liquid therein, the state of the liquid level sensor therein, and the pouring time. The basic principle is as follows: A. the consumption of liquid in the first liquid storage tank 2 and the second liquid storage tank 8 (i.e. the liquid supply amount of the first liquid storage tank 2 and the second liquid storage tank 8) by each functional sequence should be less than the total amount of the filling state of the first liquid storage tank 2 and the second liquid storage tank 8, for example, the total amount is 140mL, and the consumption is 120mL. B. Each functional sequence, if the liquid in the first reservoir 2 and the second reservoir 8 is consumed, must fill the first reservoir 2 and the second reservoir 8 before the sequence ends. C. In each functional time sequence, the time of filling can be performed separately or synchronously for the second liquid storage tank 8, so that the time consumption of instrument measurement and maintenance is greatly reduced, and the flexibility of time sequence action arrangement is improved; for the first liquid storage tank 2, the period of time for which the liquid chambers 311 of the fixed displacement pump 31 are synchronously operated is set according to the capacity, and the first liquid storage tank 2 and the fixed displacement pump 31 are usually filled at the end of the time sequence after the other action functions of the time sequence are completed.
Referring to fig. 1, an embodiment of the present invention further provides a liquid supply apparatus 100, which includes a second liquid-using component 7, a second liquid storage tank 8, a syringe (as indicated by reference numeral 9 in fig. 1), a sixth switching member 46, and a reagent tank 6. The second liquid storage pool 8 is connected with the second liquid using assembly 7 and is used for supplying liquid to the second liquid using assembly 7. The syringe is connected to the second reservoir 8 and the reagent vessel 6 via the sixth switch 46. The sixth switching member 46 is used for communicating the syringe with the reagent tank 6 to enable the syringe to draw the liquid in the reagent tank 6, or communicating the syringe with the second liquid storage tank 8 to enable the syringe to inject the liquid in the syringe into the second liquid storage tank 8.
In this embodiment, when the liquid in the second liquid storage tank 8 is sufficient, the second liquid storage tank 8 supplies the liquid to the second liquid using assembly 7. At this time, the syringe may communicate with the reagent vessel 6 through the sixth switching member 46, thereby drawing liquid from the reagent vessel 6. When the liquid in the second liquid storage tank 8 is insufficient, the injector is communicated with the second liquid storage tank 8 through the sixth switching piece 46, the injector injects the liquid in the injector into the second liquid storage tank 8 so as to supplement the liquid in the second liquid storage tank 8, so that the second liquid storage tank 8 can continuously supply the liquid for the second liquid using component 7, and therefore the second liquid storage tank 8 can realize continuous liquid supply, and the detection speed of the sample analyzer is limited due to discontinuous liquid supply, and the detection speed of the sample analyzer is higher. The injector can maintain the pressure in the second liquid storage tank 8 when the second liquid storage tank 8 is filled, so that the second liquid storage tank 8 can normally supply liquid. Since the second liquid storage tank 8 can realize continuous liquid supply without switching the internal pressure, the gas consumption of the sample analyzer can be reduced, and the energy consumption of the sample analyzer can be reduced. The syringe can stably supply the liquid into the second liquid storage tank 8.
It will be appreciated that the liquid supply apparatus 100 according to this embodiment may be designed with reference to the liquid supply apparatus 100 according to the foregoing embodiment.
Referring to fig. 1, an embodiment of the present invention further provides a liquid supply method, where the liquid supply method may use the liquid supply device 100 according to the above embodiment for supplying liquid. The liquid supply method can be used for the sample analyzer described in the above embodiments.
The liquid supply method comprises the following steps:
s01: filling standby liquid in the standby liquid storage component 3;
s02: the first liquid storage pool 2 supplies liquid for the first liquid component 1; and
s03: when the first liquid storage tank 2 is insufficient in liquid, the standby liquid storage assembly 3 supplies the standby liquid to the first liquid assembly 1.
In this embodiment, when the liquid in the first liquid storage tank 2 is sufficient, the liquid in the first liquid storage tank 2 is supplied to the first liquid component 1, and when the liquid in the first liquid storage tank 2 is insufficient, the standby liquid in the standby liquid storage component 3 can continuously supply the liquid to the first liquid component 1, so that the liquid supply method can realize continuous liquid supply, thereby avoiding the limitation of the detection speed of the sample analyzer applying the liquid supply method due to discontinuous liquid supply, and the detection speed of the sample analyzer is higher.
As an alternative embodiment, the process of "priming the spare liquid in the spare liquid storage assembly 3 (step S01)" includes:
and the first liquid storage pool 2 is communicated with the standby liquid storage assembly 3, and liquid in the first liquid storage pool 2 enters the standby liquid storage assembly 3 to form the standby liquid.
In this embodiment, the first liquid storage tank 2 supplies the liquid to the spare liquid storage assembly 3 before the first liquid storage assembly 1 supplies the liquid, so that enough liquid exists in the spare liquid storage assembly 3, and the spare liquid storage assembly 3 can supply the liquid to the first liquid storage assembly 1 when the liquid in the first liquid storage tank 2 is insufficient.
As an alternative embodiment, the standby fluid storage assembly 3 includes a fixed displacement pump 31, the fixed displacement pump 31 includes a fluid chamber 311 and a gas chamber 312, and the process of "filling the standby fluid storage assembly 3 with the standby fluid (step S01)" includes:
disconnecting the liquid chamber 311 from the first liquid assembly 1 and communicating the liquid chamber 311 with the first liquid reservoir 2, the air chamber 312 is communicated with the atmosphere or the first negative pressure source 52, the first liquid reservoir 2 is communicated with the second positive pressure source 53, and the second positive pressure source 53 pushes the liquid in the first liquid reservoir 2 into the liquid chamber 311.
Wherein the flow rate of the first negative pressure source 52 is smaller than the flow rate of the first positive pressure source 51.
In this embodiment, when the air chamber 312 is connected to the atmosphere or the first negative pressure source 52 and the liquid chamber 311 is connected to the second positive pressure source 53 through the first liquid storage tank 2, the second positive pressure source 53 pushes the diaphragm inside the dosing pump 31 toward the air chamber 312 to push the liquid in the first liquid storage tank 2 into the liquid chamber 311, so that the dosing pump 31 is mainly driven with positive pressure for filling.
As an alternative embodiment, the standby liquid storage assembly 3 includes a dosing pump 31, the dosing pump 31 includes a liquid chamber 311 and an air chamber 312, and the process of "the standby liquid storage assembly 3 supplies the standby liquid to the first liquid assembly 1 (step S03)" includes:
the liquid chamber 311 is communicated with the first liquid component 1, the air chamber 312 is communicated with a first positive pressure source 51, and the first positive pressure source 51 pushes the standby liquid in the liquid chamber 311 into the first liquid component 1.
In this embodiment, when the liquid chamber 311 is connected to the first liquid component 1 and the air chamber 312 is connected to the first positive pressure source 51, the first positive pressure source 51 pushes the diaphragm inside the dosing pump 31 toward the liquid chamber 311 to push the liquid in the liquid chamber 311 into the first liquid component 1, so that the dosing pump 31 is mainly driven by positive pressure to supply the liquid.
Therefore, the constant delivery pump 31 adopts a bidirectional positive pressure driving mode, so that the driving difficulty is low, and the energy consumption of the sample analyzer is saved.
As an alternative embodiment, the liquid supply method further includes:
s04: when the liquid in the first liquid storage tank 2 is insufficient, the first liquid storage tank 2 and the first liquid assembly 1 are disconnected and the first liquid storage tank 2 and the reagent bucket 6 are communicated, and the first liquid storage tank 2 is communicated to the second negative pressure source 54, so that the liquid in the reagent bucket 6 enters the first liquid storage tank 2 under the action of pressure difference.
It can be appreciated that step S03 and step S04 can be performed simultaneously, thereby greatly reducing the time consumed for measuring and maintaining the instrument and improving the flexibility of scheduling actions.
As an alternative embodiment, the liquid supply method further includes:
s11: the replenishing liquid component 9 extracts replenishing liquid from the reagent bucket 6;
s12: the second liquid storage pool 8 supplies liquid for the second liquid using component 7;
s13: when the liquid in the second liquid storage tank 8 is insufficient, the liquid supplementing assembly 9 fills the supplementing liquid into the second liquid storage tank 8, so that the second liquid storage tank 8 can continuously supply liquid for the second liquid using assembly 7.
In this embodiment, when the liquid in the second liquid storage tank 8 is sufficient, the second liquid storage tank 8 supplies the liquid to the second liquid using assembly 7. When the liquid in the second liquid storage tank 8 is insufficient, the liquid supplementing component 9 is communicated with the second liquid storage tank 8 through the sixth switching piece 46, the liquid in the liquid supplementing component 9 is injected into the second liquid storage tank 8 by the liquid supplementing component 9 so as to supplement the liquid in the second liquid storage tank 8, so that the second liquid storage tank 8 can continuously supply liquid for the second liquid using component 7, and therefore continuous liquid supply can be realized for the second liquid storage tank 8, and the detection speed of the sample analyzer is limited due to discontinuous liquid supply, and is relatively high. Since the second liquid storage tank 8 can realize continuous liquid supply without switching the internal pressure, the gas consumption of the sample analyzer can be reduced, and the energy consumption of the sample analyzer can be reduced.
It will be appreciated that steps S11-S13 may be performed separately from steps S01-S03, or may be performed simultaneously, thereby increasing the flexibility of the scheduling of the liquid supply method.
The foregoing has outlined rather broadly the more detailed description of embodiments of the invention, wherein the principles and embodiments of the invention are explained in detail using specific examples, the above examples being provided solely to facilitate the understanding of the method and core concepts of the invention; meanwhile, as those skilled in the art will have variations in the specific embodiments and application scope in accordance with the ideas of the present invention, the present description should not be construed as limiting the present invention in view of the above.
Claims (22)
1. The liquid supply device for the sample analyzer is characterized by comprising a first liquid component, a first liquid storage pool and a standby liquid storage component, wherein the first liquid storage pool is connected with the first liquid component and is used for supplying liquid for the first liquid component, and the standby liquid storage component is used for supplying liquid for the first liquid component when the liquid in the first liquid storage pool is insufficient; the first liquid storage pool can be switched to be communicated with the second positive pressure source and the second negative pressure source; when the first liquid storage pool is communicated with the second positive pressure source, the first liquid storage pool supplies liquid for a first liquid component; when the first liquid storage pool is communicated with the second negative pressure source, the standby liquid storage component supplies liquid for the first liquid component; the first liquid storage tank is connected with the standby liquid storage assembly and used for supplying liquid for the standby liquid storage assembly.
2. The fluid supply apparatus of claim 1, wherein a first switch is disposed between the first fluid reservoir and the first fluid component, and wherein the reserve fluid reservoir is coupled between the first switch and the first fluid component.
3. The fluid supply apparatus of claim 1, wherein a first switch and a second switch are disposed between the first fluid reservoir and the first fluid component, the reserve fluid reservoir is connected between the first switch and the second switch, the first switch is configured to be connected or disconnected, and the second switch is configured to be connected or disconnected.
4. The fluid supply apparatus of claim 1, wherein the reserve fluid reservoir assembly comprises a syringe and a drive device for driving the syringe.
5. The fluid supply apparatus of claim 1, wherein the backup fluid reservoir assembly comprises a metering pump and a third switching member, a fluid chamber of the metering pump is connected to the first fluid reservoir assembly, a fluid chamber of the metering pump is connected to the third switching member, and when the fluid chamber is in communication with a first positive pressure source through the third switching member, the first positive pressure source pushes fluid within the fluid chamber into the first fluid reservoir assembly.
6. The fluid supply apparatus of claim 5 further comprising a fourth switch, wherein the fourth switch is coupled to the first fluid reservoir, wherein the fluid chamber is coupled to the first fluid reservoir, wherein the first fluid reservoir is coupled to a second positive pressure source via the fourth switch when the air chamber is coupled to atmosphere or a first negative pressure source via the third switch, and wherein the second positive pressure source pushes fluid within the first fluid reservoir to the fluid chamber.
7. The fluid supply apparatus of claim 1, further comprising a reagent tank coupled to the first fluid reservoir, wherein fluid in the reagent tank enters the first fluid reservoir under a pressure differential when the first fluid reservoir is coupled to the second negative pressure source.
8. The liquid supply apparatus according to claim 7, wherein a fifth switching member is provided between the first liquid storage tank and the reagent tank, and the fifth switching member is configured to connect or disconnect the first liquid storage tank to or from the reagent tank.
9. The fluid supply apparatus of claim 7, further comprising a second fluid use assembly, a second fluid reservoir, a fluid replacement assembly, and a sixth switching member, wherein the second fluid reservoir is coupled to the second fluid use assembly for supplying fluid to the second fluid use assembly, and wherein the fluid replacement assembly is coupled to the second fluid reservoir and the reagent tank via the sixth switching member;
The sixth switching piece is used for communicating the fluid infusion assembly with the reagent bucket so that the fluid infusion assembly can extract liquid in the reagent bucket, or communicating the fluid infusion assembly with the second liquid storage pool so that the fluid infusion assembly can inject liquid in the fluid infusion assembly into the second liquid storage pool.
10. The fluid supply apparatus of claim 9, wherein the fluid replacement assembly comprises a syringe or a dosing pump.
11. The fluid supply apparatus of claim 9, further comprising a pressure sensor and a seventh switching element, wherein the pressure sensor is connected to the second fluid reservoir for detecting a pressure value in the second fluid reservoir, and wherein the second fluid reservoir is connected to the seventh switching element;
when the pressure value is larger than a preset value, the seventh switching piece is communicated with the second liquid storage pool to the atmosphere or a third negative pressure source.
12. The fluid supply apparatus of claim 11, wherein a flow restrictor is provided at an interface of the seventh switching element for connecting to the atmosphere or a third negative pressure source, the flow restrictor being configured to release a portion of the pressure in the second reservoir.
13. A liquid supply device for a sample analyzer, comprising a second liquid use component, a second liquid storage tank, a syringe, a sixth switching piece and a reagent barrel, wherein the second liquid storage tank is connected with the second liquid use component and is used for supplying liquid for the second liquid use component, and the syringe is connected with the second liquid storage tank and the reagent barrel through the sixth switching piece; the reagent barrel is communicated with the second liquid storage tank through the injector, and the second liquid storage tank is used for storing liquid which is the same as the liquid stored in the reagent barrel;
The sixth switching piece is used for communicating the syringe with the reagent barrel when the liquid in the second liquid storage tank is enough so that the syringe can pump the liquid in the reagent barrel, or communicating the syringe with the second liquid storage tank when the liquid in the second liquid storage tank is insufficient so that the syringe can inject the liquid in the syringe into the second liquid storage tank.
14. A sample analyser comprising a liquid supply according to any one of claims 1 to 13.
15. A method of feeding liquid for a sample analyzer according to claim 14, comprising:
filling a spare liquid in the spare liquid storage assembly; the first liquid storage pool is communicated with the standby liquid storage assembly, and liquid in the first liquid storage pool enters the standby liquid storage assembly to form standby liquid;
the first liquid storage tank supplies liquid for the first liquid component through the second positive pressure source; and
the reserve liquid reservoir assembly supplies the reserve liquid to the first liquid reservoir assembly based on a first positive pressure source when the first liquid reservoir is deficient.
16. The method of supplying liquid according to claim 15, wherein the reserve liquid storage assembly includes a dosing pump, the dosing pump including a liquid chamber and an air chamber, the process of filling the reserve liquid in the reserve liquid storage assembly comprising:
Disconnecting the liquid chamber from the first liquid component and communicating the liquid chamber with the first liquid storage tank, wherein the air chamber is communicated with atmosphere or a first negative pressure source, the first liquid storage tank is communicated with a second positive pressure source, and the second positive pressure source pushes liquid in the first liquid storage tank into the liquid chamber.
17. The method of supplying liquid of claim 15, wherein the reserve liquid storage assembly comprises a fixed displacement pump comprising a liquid chamber and a gas chamber, the process of the reserve liquid storage assembly supplying the reserve liquid to the first liquid assembly based on a first positive pressure source comprising:
the liquid chamber is communicated with the first liquid component, the air chamber is communicated with a first positive pressure source, and the first positive pressure source pushes the standby liquid in the liquid chamber into the first liquid component.
18. The method of providing liquid according to claim 15, wherein the method of providing liquid further comprises:
when the liquid in the first liquid storage pool is insufficient, the first liquid storage pool is disconnected from the first liquid assembly and communicated with the first liquid storage pool and the reagent bucket, and the first liquid storage pool is communicated to a second negative pressure source, so that the liquid in the reagent bucket enters the first liquid storage pool under the action of pressure difference.
19. The method of providing liquid according to claim 15, wherein the method of providing liquid further comprises:
the fluid replacement component extracts fluid replacement from the reagent barrel;
the second liquid storage pool is used for supplying liquid for the second liquid using component;
when the liquid in the second liquid storage pool is insufficient, the liquid supplementing assembly fills the supplementing liquid into the second liquid storage pool, so that the second liquid storage pool can continuously supply liquid for the second liquid using assembly.
20. The method of providing liquid according to claim 15, wherein the method of providing liquid further comprises: the standby liquid storage assembly comprises a syringe and a driving device for driving the syringe, wherein the process of filling standby liquid in the standby liquid storage assembly comprises the steps of communicating the syringe with the first liquid storage pool, the first liquid storage pool is communicated with a second positive pressure source, and the driving device enables liquid in the first liquid storage pool to enter the syringe.
21. The method of claim 20, wherein the first reservoir is in communication with a second positive pressure source and the drive means disconnects the syringe from the first fluid assembly before fluid from the first reservoir enters the syringe.
22. The fluid supply method of claim 20, wherein the step of supplying the backup fluid to the first fluid assembly based on the first positive pressure source includes disconnecting a syringe from a first reservoir, connecting the syringe to the first fluid assembly, and the drive device pushing the backup fluid within the syringe into the first fluid assembly.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| CNPCT/CN2017/091345 | 2017-06-30 | ||
| PCT/CN2017/091345 WO2019000459A1 (en) | 2017-06-30 | 2017-06-30 | Liquid-supply device, sample-analyzing apparatus and liquid-supply method |
| PCT/CN2018/093482 WO2019001547A1 (en) | 2017-06-30 | 2018-06-28 | Fluid supply device, sample analyzer and fluid supply method |
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| CN110741263A CN110741263A (en) | 2020-01-31 |
| CN110741263B true CN110741263B (en) | 2023-12-01 |
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| CN118183595A (en) * | 2024-03-22 | 2024-06-14 | 中元汇吉生物技术股份有限公司 | Reagent supply system, reagent supply method, and sample analyzer |
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| WO2019001547A1 (en) | 2019-01-03 |
| CN110741263A (en) | 2020-01-31 |
| WO2019000459A1 (en) | 2019-01-03 |
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