CN110650954B - 抗癌化合物 - Google Patents

抗癌化合物 Download PDF

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Publication number
CN110650954B
CN110650954B CN201880018986.1A CN201880018986A CN110650954B CN 110650954 B CN110650954 B CN 110650954B CN 201880018986 A CN201880018986 A CN 201880018986A CN 110650954 B CN110650954 B CN 110650954B
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China
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unsubstituted
hydrogen
substituted
compound
group
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Expired - Fee Related
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CN201880018986.1A
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English (en)
Chinese (zh)
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CN110650954A (zh
Inventor
利布拉达·玛丽亚·卡涅多赫南德斯
费尔南多·德拉卡列韦尔杜
玛丽亚·皮拉尔·罗德里格斯拉莫斯
玛丽亚·德尔·卡门·施勒伊斯纳桑切斯
帕兹·苏尼加吉龙
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Pharmamar SA
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Pharmamar SA
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/38—Pseudomonas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201880018986.1A 2017-03-17 2018-03-16 抗癌化合物 Expired - Fee Related CN110650954B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17382140.6 2017-03-17
EP17382140 2017-03-17
PCT/EP2018/056665 WO2018167270A1 (en) 2017-03-17 2018-03-16 Anticancer compounds

Publications (2)

Publication Number Publication Date
CN110650954A CN110650954A (zh) 2020-01-03
CN110650954B true CN110650954B (zh) 2023-11-03

Family

ID=58398130

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880018986.1A Expired - Fee Related CN110650954B (zh) 2017-03-17 2018-03-16 抗癌化合物

Country Status (17)

Country Link
US (1) US20210317490A1 (https=)
EP (1) EP3596068A1 (https=)
JP (1) JP7209633B2 (https=)
KR (1) KR102547649B1 (https=)
CN (1) CN110650954B (https=)
AU (2) AU2018235140B2 (https=)
BR (1) BR112019019301A2 (https=)
CA (1) CA3056725A1 (https=)
CL (2) CL2019002661A1 (https=)
IL (2) IL292572A (https=)
MA (1) MA49880A (https=)
MX (2) MX392144B (https=)
MY (2) MY202630A (https=)
SG (1) SG11201908267XA (https=)
UA (1) UA126338C2 (https=)
WO (1) WO2018167270A1 (https=)
ZA (2) ZA201906518B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12156523B2 (en) 2017-03-17 2024-12-03 Mmag Co., Ltd. Plant disease control agent
CN114615999B (zh) * 2019-09-05 2024-03-08 法马马有限公司 药物抗体偶联物
CN112661808B (zh) * 2020-12-23 2022-05-27 浙江大学 一种酯肽类化合物及其制备方法和应用
EP4326869A4 (en) * 2021-04-20 2025-12-10 Univ Of Louisville RECOMBINATING MICRO-NECK

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003044186A2 (en) * 2001-11-22 2003-05-30 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Novel gene cluster of pederin biosynthesis genes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2040338T3 (es) 1987-04-29 1993-10-16 Harbor Branch Oceanographic Institution, Inc. Compuestos antitumorales y antiviricos de origen marino.
US4801606A (en) 1987-07-17 1989-01-31 Harbor Branch Oceanographic Institution Inc. Antiviral compositions
WO2013016120A1 (en) 2011-07-22 2013-01-31 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Pederin and psymberin agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003044186A2 (en) * 2001-11-22 2003-05-30 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Novel gene cluster of pederin biosynthesis genes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Labrenzia sp.strain PHM005 16S ribosomal RNA gene. partial sequence.;Schleissner,C. 等;《EMBL》;20161117;KX661380 *
R.Narquizian 等.The pederin family of antitumor agents：structures，synthesis and biological activity.《The Role of Natural Products in Drug Discovery》.2000,第25-56页. *

Also Published As

Publication number Publication date
KR20190129950A (ko) 2019-11-20
MX2019010890A (es) 2019-12-19
IL269353B (en) 2022-06-01
AU2018235140B2 (en) 2021-11-11
CL2019002661A1 (es) 2019-12-27
JP2020510065A (ja) 2020-04-02
CA3056725A1 (en) 2018-09-20
IL269353A (en) 2019-11-28
WO2018167270A1 (en) 2018-09-20
RU2019132808A3 (https=) 2021-10-04
AU2021277683A1 (en) 2021-12-23
JP7209633B2 (ja) 2023-01-20
IL292572A (en) 2022-06-01
CN110650954A (zh) 2020-01-03
US20210317490A1 (en) 2021-10-14
AU2018235140A1 (en) 2019-10-03
AU2021277683B2 (en) 2023-03-09
MX2021011385A (es) 2021-10-13
MX392144B (es) 2025-03-21
CL2021000117A1 (es) 2021-07-30
MA49880A (fr) 2020-06-24
MY202630A (en) 2024-05-10
EP3596068A1 (en) 2020-01-22
KR102547649B1 (ko) 2023-06-23
UA126338C2 (uk) 2022-09-21
MY195435A (en) 2023-01-20
RU2019132808A (ru) 2021-04-19
ZA201906518B (en) 2021-01-27
SG11201908267XA (en) 2019-10-30
BR112019019301A2 (pt) 2020-04-28
ZA202006147B (en) 2023-03-29

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