CN110604633B - Vascular stent coating film with integrally variable structure and manufacturing method thereof - Google Patents

Vascular stent coating film with integrally variable structure and manufacturing method thereof Download PDF

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Publication number
CN110604633B
CN110604633B CN201910993366.6A CN201910993366A CN110604633B CN 110604633 B CN110604633 B CN 110604633B CN 201910993366 A CN201910993366 A CN 201910993366A CN 110604633 B CN110604633 B CN 110604633B
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Prior art keywords
stent
blood vessel
artificial blood
coating
thickness
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CN110604633A (en
Inventor
陈涛
杜广武
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Jiangsu Baiyouda Life Technology Co ltd
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Jiangsu Baiyouda Life Technology Co ltd
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0069Three-dimensional shapes cylindrical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001Designing or manufacturing processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0029Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in bending or flexure capacity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0036Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in thickness
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter

Landscapes

  • Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

The invention discloses a vascular stent coating with an integrated variable structure and a manufacturing method thereof, comprising an artificial blood vessel and a stent coating which are connected without gaps, wherein the stent coating is of a fabric structure woven by polyester filaments, and the thickness of the stent coating is about 50% of the thickness of the artificial blood vessel. According to the invention, a weaving method is adopted to manufacture a seamless integrated structure with an artificial blood vessel and a stent coating, and the density of warp and weft yarns is adjusted during weaving, so that on one hand, the diameter of the coating is changed to form a variable-diameter shape, and on the other hand, the thickness of the coating part of the stent section is reduced, thus not only improving the bending performance of the blood vessel stent, but also being beneficial to compressing the stent coating into a thinner delivery sheath.

Description

Vascular stent coating film with integrally variable structure and manufacturing method thereof
Technical Field
The invention belongs to the field of artificial blood vessels, and particularly relates to a vascular stent coating with an integrated variable structure and a manufacturing method thereof.
Background
The covered stent in the prior art is a covered stent formed by suturing a stent section and a covered membrane, and the covered membrane is fixed on normal vascular walls at two ends of a lesion by utilizing the low permeability of the covered membrane and the supporting function of the stent, so that blood flows in the covered membrane to be isolated from a tumor cavity and the false cavity is thrombosed, thereby realizing the effect of treating the lesion vascular.
The further artificial vascular stent is a covered stent with a human hematopoietic tube end, and can be anastomosed with a blood vessel of a human body in clinic, but the current aortic covered stent used for clinic is mostly made of PET materials, but because the covered membranes of the human hematopoietic tube section and the stent section adopt the same structure, the stent section has harder texture after covered suturing due to larger thickness of the covered membrane, is difficult to bend and is not easy to compress into a thinner conveying sheath. When the tectorial membrane of the support section part adopts a mode with lower thickness, the tectorial membrane needs to be sutured with an artificial blood vessel part, so that a more obvious suture superposition part can be generated, the thickness of the part is increased, thrombus is easy to form at a suture part, and hidden danger is brought to clinical effects while the production difficulty of a product is increased.
Disclosure of Invention
In view of the above problems, the present invention provides a stent graft of an integrally variable structure and a method for manufacturing the same.
The technical aim is achieved, and the technical effects are achieved by the following technical scheme:
a vascular stent coating with an integrated variable structure comprises an artificial blood vessel and a stent coating which are connected without gaps, wherein the stent coating is of a fabric structure woven by polyester filaments, and the thickness of the stent coating is about 50% of the thickness of the artificial blood vessel.
As a further improvement of the invention, the thickness of the artificial blood vessel is 0.300-0.350 mm.
As a further improvement of the invention, the thickness of the stent coating is 0.150-0.200 mm.
As a further improvement of the present invention, the artificial blood vessel and the stent graft have different diameters.
As a further improvement of the invention, the diameter of the stent-graft is smaller than the diameter of the artificial blood vessel, and the diameter of the stent-graft decreases linearly and uniformly within a certain length range from the connecting position of the stent-graft and the artificial blood vessel.
As a further improvement of the invention, the artificial hematopoietic tube section is a fabric with a satin structure, and the bracket section coating is a fabric with a plain weave structure.
As a further improvement of the invention, the warp and weft yarn density of the stent section coating is smaller than that of the artificial blood vessel section.
A method for braiding a vascular stent with an integrally variable structure as described above by using polyester filaments includes braiding a satin weave structure as an artificial vascular part by a weave method of up and down of 6, then reducing the number of yarns by a jacquard control method and braiding a plain weave structure as a stent-covering part by a weave method of up and down of 1, and the densities of warp and weft yarns in the braiding process are adjusted according to the thickness and diameter of the artificial vascular part or the stent-covering part.
The invention has the beneficial effects that: according to the invention, a weaving method is adopted to manufacture a seamless integrated structure with an artificial blood vessel and a stent coating, and the density of warp and weft yarns is adjusted during weaving, so that on one hand, the diameter of the coating is changed to form a variable-diameter shape, and on the other hand, the thickness of the coating part of the stent section is reduced, thus not only improving the bending performance of the blood vessel stent, but also being beneficial to compressing the stent coating into a thinner delivery sheath.
Drawings
FIG. 1 is a schematic diagram of an embodiment of the present invention;
wherein: 1-artificial blood vessel, 2-stent coating.
Detailed Description
The present invention will be described in further detail with reference to the following examples in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
The principle of application of the invention is described in detail below with reference to the accompanying drawings.
The vascular stent coating structure with an integrated variable structure shown in fig. 1 comprises an artificial blood vessel 1 and a stent coating 2 which are connected without gaps, and the connecting part between the artificial blood vessel 1 and the stent coating 2 does not need to be sewed and has no excessively thick folding and wrinkling by adopting a fabric structure woven by polyester filaments. The artificial blood vessel 1 and the stent coating 2 with different tissue structures can be woven through different weaving methods, wherein the artificial blood vessel 1 section is a fabric with a satin structure, and the stent coating 2 section is a fabric with a plain structure.
The thickness of the stent coating 2 is about 50% of the thickness of the artificial blood vessel 1. In the present invention, the thickness of the artificial blood vessel 1 in the vascular stent coating film with the integrated variable structure is 0.300 mm-0.350 mm. The thickness of the stent coating 2 is 0.150 mm-0.200 mm. By reducing the thickness of the stent graft 2 to be sutured with the stent segments, localized excessive thickness at the site of the suture is avoided.
The diameter of the stent coating 2 is smaller than that of the artificial blood vessel 1, and in order to ensure the gapless connection between the stent coating 2 and the artificial blood vessel, the diameter of the stent coating 2 is linearly and uniformly reduced within a certain length range from the connection position of the stent coating 2 and the artificial blood vessel. For example, in one embodiment of the invention, the length of the manufactured artificial blood vessel 1 part is 100mm, the length of the stent section covered part is 100mm, the diameter of the artificial blood vessel 1 part is 33mm, the inner diameter of the stent section covered part is uniformly changed from 32mm to 30mm at a distance of 50mm by taking the connecting position of the stent section covered part and the stent section covered part as the starting end, and the diameter of the stent section covered part is stabilized at 30mm at 50mm at the rear end. A stent graft 2 of finer diameter may also be obtained, facilitating compression into a finer delivery sheath.
The structure can be manufactured by changing the densities of warp and weft yarns of the artificial blood vessel 1 part or the stent coating 2 part according to the thickness and diameter requirements in the manufacturing process, and the specific manufacturing steps of one embodiment of the invention are as follows:
(1) Yarn selection: the warp yarn adopts 2 40D yarns to be doubled and twisted for 300 twists/m, and the weft yarn adopts 4 40 yarns to be doubled and twisted for 200 twists/m.
(2) The 792 yarns are used and divided into 48 reed, the 6 up and down weave method is adopted, the warp yarn density is 180ends/inch, the weft yarn density is 170 meshes/inch, the satin structure of the part of the artificial blood vessel 1 is woven, and the length of the woven part of the artificial blood vessel 1 is 100mm, and the diameter is 33mm.
(3) The number of yarns is reduced to 396 by jacquard control, a 1-over-1 weaving method is adopted to weave a plain weave structure of a bracket film 2 part with the warp density of 100ends/inch and the weft density of 100 meshes/inch, the total length of the bracket film 2 part is 100mm, the diameter of the bracket film 2 part is 32mm at the starting point, and the diameter is uniformly reduced to 30mm within the range of 50mm.
(4) After weaving, carrying out subsequent steps such as cleaning, drying, heat setting and the like to obtain the finally required tubular vascular stent coating 2.
The thickness of the artificial blood vessel 1 part in the vascular stent coating 2 obtained by measurement after the weaving is finished is 0.334mm, the thickness of the stent section coating part is 176mm, and the thickness of the stent section coating part is reduced by 50 percent compared with the thickness of the artificial blood vessel 1 part.
The foregoing has shown and described the basic principles and main features of the present invention and the advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (3)

1. A vascular stent coating of an integral variable structure, which is characterized in that: comprises an artificial blood vessel and a bracket tectorial membrane which are connected without gaps, wherein the bracket tectorial membrane is of a fabric structure woven by polyester filaments, and the thickness of the bracket tectorial membrane is 50% of the thickness of the artificial blood vessel;
the diameters of the artificial blood vessel and the stent coating are different, the diameter of the stent coating is smaller than that of the artificial blood vessel, and the diameter of the stent coating is linearly and uniformly reduced in the range from the connecting position of the two to the midpoint position;
the artificial blood vessel is a fabric with a satin structure, and the bracket coating is a fabric with a plain structure; the warp and weft yarn density of the stent coating is smaller than that of the artificial blood vessel;
the satin weave structure is woven by adopting a weaving method of up and down 6 and is used as an artificial blood vessel part, then the number of yarns is reduced by a jacquard control method, and the plain weave structure is woven by adopting a weaving method of up and down 1 and is used as a stent covering part, and the density of warp and weft yarns in the weaving process is regulated according to the thickness and the diameter of the artificial blood vessel part or the stent covering part.
2. A stent graft of unitary variable construction according to claim 1, wherein: the thickness of the artificial blood vessel is 0.300 mm-0.350 mm.
3. A stent graft according to claim 1 or 2, wherein: the thickness of the stent coating is 0.150 mm-0.200 mm.
CN201910993366.6A 2019-10-18 2019-10-18 Vascular stent coating film with integrally variable structure and manufacturing method thereof Active CN110604633B (en)

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CN110604633B true CN110604633B (en) 2024-03-05

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Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113463243B (en) * 2020-03-11 2023-08-18 浙江脉通智造科技(集团)有限公司 Artificial blood vessel and preparation method thereof
CN111544170B (en) * 2020-05-13 2021-12-10 东华大学 Anti-slip narrow-resistance esophageal stent with mesoporous structure

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008052422A1 (en) * 2006-10-31 2008-05-08 Ning Wen Stent valve with stent and biovalve woven integrally and manufacturing method thereof
CN104689379A (en) * 2015-02-15 2015-06-10 东华大学 Woven integrally formed blood vessel covered stent and preparation method thereof
WO2015090237A1 (en) * 2013-12-20 2015-06-25 微创神通医疗科技(上海)有限公司 Vascular stent and method for manufacturing same
CN105105867A (en) * 2015-07-16 2015-12-02 东华大学 Integrally-molded woven blood vessel covered stent and preparation method thereof
JP2018175776A (en) * 2017-04-21 2018-11-15 グンゼ株式会社 Covered stent
CN109106468A (en) * 2018-08-14 2019-01-01 江苏百优达生命科技有限公司 A kind of artificial blood vessel structure that can improve compliance
CN211381984U (en) * 2019-10-18 2020-09-01 江苏百优达生命科技有限公司 Vascular stent tectorial membrane of integrative variable structure

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008052422A1 (en) * 2006-10-31 2008-05-08 Ning Wen Stent valve with stent and biovalve woven integrally and manufacturing method thereof
WO2015090237A1 (en) * 2013-12-20 2015-06-25 微创神通医疗科技(上海)有限公司 Vascular stent and method for manufacturing same
CN104689379A (en) * 2015-02-15 2015-06-10 东华大学 Woven integrally formed blood vessel covered stent and preparation method thereof
CN105105867A (en) * 2015-07-16 2015-12-02 东华大学 Integrally-molded woven blood vessel covered stent and preparation method thereof
JP2018175776A (en) * 2017-04-21 2018-11-15 グンゼ株式会社 Covered stent
CN109106468A (en) * 2018-08-14 2019-01-01 江苏百优达生命科技有限公司 A kind of artificial blood vessel structure that can improve compliance
CN211381984U (en) * 2019-10-18 2020-09-01 江苏百优达生命科技有限公司 Vascular stent tectorial membrane of integrative variable structure

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