CN110477871A - For moving freely the photoacoustic tomography device of experimental animal Brian Imaging under state - Google Patents
For moving freely the photoacoustic tomography device of experimental animal Brian Imaging under state Download PDFInfo
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- CN110477871A CN110477871A CN201910852664.3A CN201910852664A CN110477871A CN 110477871 A CN110477871 A CN 110477871A CN 201910852664 A CN201910852664 A CN 201910852664A CN 110477871 A CN110477871 A CN 110477871A
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- 238000003384 imaging method Methods 0.000 title claims abstract description 84
- 238000003325 tomography Methods 0.000 title claims abstract description 33
- 238000010171 animal model Methods 0.000 title claims abstract description 16
- 239000000835 fiber Substances 0.000 claims abstract description 50
- 230000008878 coupling Effects 0.000 claims abstract description 25
- 238000010168 coupling process Methods 0.000 claims abstract description 25
- 238000005859 coupling reaction Methods 0.000 claims abstract description 25
- 238000012545 processing Methods 0.000 claims abstract description 21
- 230000003287 optical effect Effects 0.000 claims description 16
- 230000005540 biological transmission Effects 0.000 claims description 13
- 210000000988 bone and bone Anatomy 0.000 claims description 6
- 230000005284 excitation Effects 0.000 claims description 6
- 238000013519 translation Methods 0.000 claims description 6
- 239000007822 coupling agent Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 2
- 230000005611 electricity Effects 0.000 claims 2
- 238000009738 saturating Methods 0.000 claims 1
- 238000010586 diagram Methods 0.000 description 8
- 238000001514 detection method Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000003625 skull Anatomy 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002610 neuroimaging Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
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- Heart & Thoracic Surgery (AREA)
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- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Acoustics & Sound (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
Abstract
The embodiment of the invention discloses a kind of for moving freely the photoacoustic tomography device of experimental animal Brian Imaging under state, which includes: light source assembly, and bracket is imaged in fiber bundle coupling component；Imaging bracket is connect with fiber bundle coupling component, and the periphery that bracket is imaged is formed with round sliding slot；Signal acquisition component, including a photoacoustic signal detector, for detecting the photoacoustic signal inspired by the imaging position of object, photoacoustic signal detector is mobilizable to be set in round sliding slot photoacoustic signal detector；Electronically controlled rotary table component, electronically controlled rotary table component are connect with photoacoustic signal detector；Signal processing component, signal processing component are connect with light source assembly, signal acquisition component and electronically controlled rotary table component respectively.Photoacoustic tomography device provided in an embodiment of the present invention is significantly improved compared to traditional photoacoustic tomography system imaging quality for moving freely experimental animal Brian Imaging under state.
Description
Technical field
The present embodiments relate to imaging techniques, and in particular to one kind is for moving freely experimental animal Brian Imaging under state
Photoacoustic tomography device.
Background technique
The brain imaging for moving freely experimental animal under state is of great significance to medical research, compared to traditional medicine
Image technology, photoacoustic imaging system be easier to miniaturization with it is integrated, to be placed in experimental animal brain.Photoacoustic imaging technology
It is imaged by the ultrasonic wave of direct impulse laser excitation, has both optical imagery and ultrasonic imaging double dominant, had abundant
Contrast source and higher resolution ratio and imaging depth, and three-dimensional information can be obtained, the above feature makes
Obtaining photoacoustic imaging technology, there is great application potentials in terms of the real-time Brian Imaging of free-moving experimental animal.
Currently, the existing state experimental animal living body Brian Imaging photoacoustic tomography system that moves freely mostly uses piezoelectricity thin
Array type detector is made to mitigate weight to the maximum extent in membrane material, reduces volume.However use the battle array of piezoelectric film material
Column detector image-forming is second-rate, and needs cumbersome calibration steps, seriously limits photoacoustic technique answering in the field
With.
Summary of the invention
The embodiment of the present invention provides a kind of photoacoustic tomography dress for moving freely experimental animal Brian Imaging under state
It sets, the image quality of photoacoustic tomography can be effectively improved.
In a first aspect, the embodiment of the invention provides a kind of for moving freely the optoacoustic of experimental animal Brian Imaging under state
Laminated imaging device, comprising:
Light source assembly, for providing the light source of excitation photoacoustic signal；
Fiber bundle coupling component, the light issued for coupling and transmitting the light source assembly；
Bracket is imaged, for being fixed on the imaging position of object；The imaging bracket and the fiber bundle coupling component
The periphery of connection, the imaging bracket is formed with round sliding slot；
Signal acquisition component, including a photoacoustic signal detector, the photoacoustic signal detector is for detecting by described
The photoacoustic signal that the imaging position of object inspires, the photoacoustic signal detector is mobilizable to be set to the round sliding slot
In；
Electronically controlled rotary table component, the electronically controlled rotary table component are connect with the photoacoustic signal detector, the automatically controlled rotation
Turntable Assemblies are for controlling the photoacoustic signal detector along the round runner movement；
Signal processing component, the signal processing component respectively with the light source assembly, the signal acquisition component and institute
The connection of electronically controlled rotary table component is stated, the signal processing component obtains the target for handling the photoacoustic signal
The image at the imaging position of object.
Optionally, the light source assembly includes pulse pumped laser and optical parametric oscillator；The pulse pump swashs
Light device and optical parametric oscillator electrical connection；
The pulse pumped laser is used to issue the pulse pump laser of fixed wave length；
The optical parametric oscillator is used to adjust the wavelength of the pulse pump laser.
Optionally, the fiber bundle coupling component includes lens, fiber optic bundle, fiber optic bundle clamper and five dimension translation stages；Institute
It states lens and the fiber optic bundle clamper is mounted on the five dimensions translation stage；
The lens are used for the optical coupling that issues the light source assembly into the fiber optic bundle；The fiber optic bundle clamper is used
In the input terminal of the fixation fiber optic bundle, the output end of the fiber optic bundle is fixed on the imaging bracket.
Optionally, the output end of the fiber optic bundle is fixed on the center of the imaging cantilever tip.
Optionally, the electronically controlled rotary table component includes electronically controlled rotary table, Flexible Transmission hose and electronically controlled rotary table control
Device；The photoacoustic signal detector is connect by the Flexible Transmission hose with the electronically controlled rotary table；The electronically controlled rotary table
Controller is connect with the electronically controlled rotary table；
The electronically controlled rotary table is used to drive the photoacoustic signal detector along the circle by the Flexible Transmission hose
Shape runner movement；
The electronically controlled rotary table controller is for controlling the electronically controlled rotary table rotation.
Optionally, the center of the electronically controlled rotary table offers through-hole, and the fiber optic bundle passes through the through-hole and is fixed to institute
It states on imaging bracket.
Optionally, the signal acquisition component further includes signal amplifier and data collecting card, the photoacoustic signal detection
Device is connect with the signal amplifier, and the signal amplifier is connect with the data collecting card；
The photoacoustic signal that the signal amplifier is used to detect the photoacoustic signal detector amplifies；
The amplified photoacoustic signal is transferred to by the data collecting card for acquiring amplified photoacoustic signal
The signal processing component.
Optionally, bone wax is provided on the imaging bracket, the bone wax is used to for the imaging bracket being fixed on described
Position is imaged.
Optionally, the photoacoustic signal detector is miniature ultrasonic detector.
Optionally, the inside of the imaging bracket is equipped with ultrasonic coupling agent.
The embodiment of the invention provides a kind of for moving freely the photoacoustic tomography of experimental animal Brian Imaging under state
At device, including light source assembly, fiber bundle coupling component, imaging bracket, signal acquisition component, electronically controlled rotary table component and signal
Component is managed, imaging bracket is fixed on the imaging position of object, and the periphery that bracket is imaged is formed with round sliding slot, signal acquisition group
Part includes a photoacoustic signal detector, and photoacoustic signal detector is mobilizable to be set in round sliding slot, electronically controlled rotary table group
Part is connect with photoacoustic signal detector, signal processing component respectively with light source assembly, signal acquisition component and electronically controlled rotary table group
Part connection.The light source that excitation photoacoustic signal is issued by light source assembly passes through the coupling of fiber bundle coupling component and transmission light source group
The light that part issues, and by electronically controlled rotary table component control photoacoustic signal detector along round runner movement, to be believed by optoacoustic
Number detector detects the photoacoustic signal inspired by the imaging position of object, is carried out by signal processing component to photoacoustic signal
Reason, the image for obtaining the imaging position of object are visited compared with the existing photoacoustic tomography device using array architecture
Device is surveyed along round runner movement and single detector does not need to calibrate, can effectively improve photoacoustic tomography at image quality
Amount.
Detailed description of the invention
Fig. 1 is a kind of structural block diagram for photoacoustic tomography device that the embodiment of the present invention one provides；
Fig. 2 is a kind of the schematic diagram of the section structure for imaging bracket that the embodiment of the present invention one provides；
Fig. 3 is a kind of structural block diagram of photoacoustic tomography device provided by Embodiment 2 of the present invention；
Fig. 4 is a kind of structural schematic diagram of photoacoustic tomography device provided by Embodiment 2 of the present invention.
Specific embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples.It is understood that this place is retouched
The specific embodiment stated is used only for explaining the present invention rather than limiting the invention.It also should be noted that in order to just
Only the parts related to the present invention are shown in description, attached drawing rather than entire infrastructure.
Embodiment one
Mostly use array architecture based on existing photoacoustic tomography device, in order to mitigate weight and simplify structure and
Affect image quality, present embodiments provide it is a kind of for move freely experimental animal Brian Imaging under state optoacoustic chromatograph at
As device.It illustratively, is a kind of photoacoustic tomography device of the offer of the embodiment of the present invention one with reference to Fig. 1 and Fig. 2, Fig. 1
Structural block diagram, Fig. 2 are a kind of the schematic diagram of the section structure for imaging bracket that the embodiment of the present invention one provides, and the present embodiment is applicable
In free-moving mouse/rat Brian Imaging photoacoustic tomography the case where, which includes: light source group
Part 10, fiber bundle coupling component 20, imaging bracket 30, signal acquisition component 40, electronically controlled rotary table component 50 and signal processing group
Part 60；
Light source assembly 10 is used to provide the light source of excitation photoacoustic signal；
Fiber bundle coupling component 20 is used for the light coupled and transmission light source component issues；
Imaging bracket 30 is used to be fixed on the imaging position of object；Bracket 30 is imaged and fiber bundle coupling component 20 connects
It connects, the periphery of imaging bracket 30 is formed with round sliding slot 301；
Signal acquisition component 40 includes a photoacoustic signal detector 401, and photoacoustic signal detector 401 is for detecting by mesh
The photoacoustic signal that the imaging position of mark object inspires, photoacoustic signal detector 401 is mobilizable to be set in round sliding slot 301；
Electronically controlled rotary table component 50 is connect with photoacoustic signal detector 401, and electronically controlled rotary table component 50 is for controlling optoacoustic
Signal sensor 401 is moved along round sliding slot 301；
Signal processing component 60 is connect with light source assembly 10, signal acquisition component 40 and electronically controlled rotary table component 50 respectively,
Signal processing component 60 obtains the image at the imaging position of object for handling photoacoustic signal.
Illustratively, the capable of emitting Wavelength tunable of light source assembly 10, light of the pulsewidth between 5ns-10ns, pass through fiber coupling
It is solid that bracket 30 is imaged in optical transport that light source assembly 10 issues to the imaging bracket 30 connecting with fiber coupling component 20 by component 20
The light for being scheduled on the imaging position of object, therefore being transferred to imaging bracket 30 can excite the imaging position of object to issue optoacoustic letter
Number, thus by the detection of photoacoustic signal detector 401 in the round sliding slot 301 that is set to imaging bracket 30 by object at
Photoacoustic signal is transferred to signal processing component 60 as the photoacoustic signal that position inspires, and by signal acquisition component 40, is made
Signal processing component 60 handles photoacoustic signal, obtains the image at the imaging position of object.
Specifically, controlling optoacoustic by electronically controlled rotary table component 50 when photoacoustic signal detector 401 detects photoacoustic signal
Signal sensor 401 is moved along round sliding slot 301, so that photoacoustic signal detector 401 detects the imaging position of object
The photoacoustic signal that all directions inspire.Single photoacoustic signal detector replaces the detector of array, eliminates the step of calibration
Suddenly, the problem poor because of calibration bring image quality is reduced, so that imaging effect is effectively improved.
The photoacoustic tomography device provided in this embodiment for being used to move freely experimental animal Brian Imaging under state, including
Light source assembly, fiber bundle coupling component, imaging bracket, signal acquisition component, electronically controlled rotary table component and signal processing component, at
As bracket is fixed on the imaging position of object, the periphery that bracket is imaged is formed with round sliding slot, and signal acquisition component includes one
A photoacoustic signal detector, photoacoustic signal detector is mobilizable to be set in round sliding slot, electronically controlled rotary table component and optoacoustic
Signal sensor connection, signal processing component are connect with light source assembly, signal acquisition component and electronically controlled rotary table component respectively.It is logical
The light source that light source assembly issues excitation photoacoustic signal is crossed, couples what simultaneously transmission light source component issued by fiber bundle coupling component
Light, and by electronically controlled rotary table component control photoacoustic signal detector along round runner movement, to pass through photoacoustic signal detector
The photoacoustic signal inspired by the imaging position of object is detected, photoacoustic signal is handled by signal processing component, is obtained
The image at the imaging position of object, compared with the existing photoacoustic tomography device using array architecture, detector edge
Round runner movement and single detector do not need to calibrate, and can effectively improve the image quality of photoacoustic tomography.
Embodiment two
Fig. 3 is a kind of structural block diagram of photoacoustic tomography device provided by Embodiment 2 of the present invention, and Fig. 4 is of the invention real
A kind of structural schematic diagram of sound laminated imaging device of the offer of example two is provided, based on the above technical solution, optionally, reference
Fig. 3 and Fig. 4, light source assembly 10 include pulse pumped laser 101 and optical parametric oscillator 102；Pulse pumped laser 101
It is electrically connected with optical parametric oscillator 102；Pulse pumped laser 101 is used to issue the pulse pump laser of fixed wave length；Light
Learn the wavelength that parametric oscillator 102 is used to adjust pulse pump laser.
Wherein, pulse pumped laser 101 issues the pulse pump laser of a 532nm wavelength, and pulse pump laser exists
Be converted into the pulse laser of any wavelength after optical parametric oscillator 102, the pulsewidth of pulse laser 5ns-10ns it
Between.
Optionally, fiber bundle coupling component 20 includes that lens 201, fiber optic bundle 202, fiber optic bundle clamper 203 and five dimensions are flat
Moving stage 204；Lens 201 and fiber optic bundle clamper 203 are mounted on five dimension translation stages 204；Lens 201 are for sending out light source assembly 10
Optical coupling out is into fiber optic bundle 202；Fiber optic bundle clamper 203 is used to fix the input terminal of fiber optic bundle 202, fiber optic bundle 202 it is defeated
Outlet is fixed on imaging bracket 30.
Specifically, lens 201, fiber optic bundle 202, fiber optic bundle clamper 203, pulse pumped laser 101 and Optical Parametric
The number coaxial installation of oscillator 102, the input terminal of fiber optic bundle 202 are fixed on fiber optic bundle clamper 203, and five dimension translation stages 204 are set
It is equipped with knob, position and pitching of the fiber optic bundle 202 in three-dimensional space on five dimension translation stages 204 can be adjusted by twisting knob
Angle improves pulse laser coupling efficiency to maximum.
Optionally, the output end of fiber optic bundle 202 is fixed on the center on imaging 30 top of bracket, so that in light shafts 202
Pulse laser is transmitted to imaging bracket 30.
Optionally, electronically controlled rotary table component 50 includes electronically controlled rotary table 501, Flexible Transmission hose 502 and electronically controlled rotary table
Controller 503；Photoacoustic signal detector 401 is connect by Flexible Transmission hose 502 with electronically controlled rotary table 501；Electronically controlled rotary table
Controller 503 is connect with electronically controlled rotary table 501；Electronically controlled rotary table 501 is used to drive photoacoustic signal by Flexible Transmission hose 502
Detector 401 is along round runner movement；Electronically controlled rotary table controller 503 is for controlling the rotation of electronically controlled rotary table 501.
Specifically, electronically controlled rotary table 501 is provided with rotating electric machine, electronically controlled rotary table controller 503 passes through control electric rotating
To make electronically controlled rotary table 501 rotate, electronically controlled rotary table 501 passes through Flexible Transmission hose 502 after rotating and drives photoacoustic signal machine
Detector 401 is along round runner movement, the photoacoustic signal inspired with all directions at the imaging position of detecting objects.
Optionally, the center of electronically controlled rotary table 501 offers through-hole, and fiber optic bundle 202 passes through through-hole and is fixed to imaging bracket
On 30, prevents light shafts 202 and the winding of other connecting lines when object is mobile and influence collection effect, object can be reality
Test for example free-moving mouse of animal etc..
Optionally, signal acquisition component 40 further includes signal amplifier 402 and data collecting card 403, photoacoustic signal detection
Device 401 connect 402 with signal amplifier, and signal amplifier 402 is connect with data collecting card 403；Signal amplifier 402 for pair
The photoacoustic signal that photoacoustic signal detector 401 detects amplifies；Data collecting card 403 is for acquiring amplified optoacoustic letter
Number, and amplified photoacoustic signal is transferred to signal processing component 60.
Specifically, the photoacoustic signal that signal acquisition component 40 can be excited with acquisition pulse laser in object brain, at this time
Imaging bracket can be fixed on the skull of object, and signal acquisition component 40 includes computer, and computer is provided with acquisition control
Software and data processing software processed, acquisition control software can be Labview software；It is soft that data processing software can be Matlab
Part；Acquisition control software is scanned imageable target for controlling light source assembly, and control electronically controlled rotary table component and letter
Photoacoustic signal in number acquisition component acquisition imaging region at each scanning element；Data processing software believes collected optoacoustic
It number is handled, reconstructs the image of imageable target.
Optionally, it is imaged on bracket 30 and is provided with bone wax, bone wax is fixed on imaging position for bracket 30 will to be imaged.
Specifically, imaging bracket can also be fixed on imaging position, such as experimental animal by the common medical material such as dentistry powder
Skull on.
Optionally, photoacoustic signal detector 401 is miniature ultrasonic detector.
Wherein, miniature ultrasonic detector 401 has biggish deflection, can not reconstruct entirely by a signal detection
The distribution of optical absorption parameter in imaging region, more accurate photoacoustic image in imaging region, needs different in order to obtain
Detecting location is respectively completed primary (or multiple) signal detection.
Optionally, the inside that bracket 30 is imaged is equipped with ultrasonic coupling agent, and the photoacoustic signal that pulse laser is excited transmits
Give signal acquisition component.
It should be noted that during photoacoustic tomography, the wavelength of laser output, sampling when signal acquisition
Rate, the parameters such as step-length of rotating electric machine can be selected according to the actual situation, it is not limited here.
Note that the above is only a better embodiment of the present invention and the applied technical principle.It will be appreciated by those skilled in the art that
The invention is not limited to the specific embodiments described herein, be able to carry out for a person skilled in the art it is various it is apparent variation,
It readjusts and substitutes without departing from protection scope of the present invention.Therefore, although being carried out by above embodiments to the present invention
It is described in further detail, but the present invention is not limited to the above embodiments only, without departing from the inventive concept, also
It may include more other equivalent embodiments, and the scope of the invention is determined by the scope of the appended claims.
Claims (10)
1. a kind of for moving freely the photoacoustic tomography device of experimental animal Brian Imaging under state characterized by comprising
Light source assembly, for providing the light source of excitation photoacoustic signal；
Fiber bundle coupling component, the light issued for coupling and transmitting the light source assembly；
Bracket is imaged, for being fixed on the imaging position of object；The imaging bracket is connect with the fiber bundle coupling component,
The periphery of the imaging bracket is formed with round sliding slot；
Signal acquisition component, including a photoacoustic signal detector, the photoacoustic signal detector is for detecting by the target
The photoacoustic signal that the imaging position of object inspires, the photoacoustic signal detector is mobilizable to be set in the round sliding slot；
Electronically controlled rotary table component, the electronically controlled rotary table component are connect with the photoacoustic signal detector, the electronically controlled rotary table
Component is for controlling the photoacoustic signal detector along the round runner movement；
Signal processing component, the signal processing component respectively with the light source assembly, the signal acquisition component and the electricity
Turntable component connection is controlled, the signal processing component obtains the object for handling the photoacoustic signal
The image at position is imaged.
2. photoacoustic tomography device according to claim 1, which is characterized in that the light source assembly includes pulse pump
Laser and optical parametric oscillator；The pulse pumped laser and optical parametric oscillator electrical connection；
The pulse pumped laser is used to issue the pulse pump laser of fixed wave length；
The optical parametric oscillator is used to adjust the wavelength of the pulse pump laser.
3. photoacoustic tomography device according to claim 1, which is characterized in that the fiber bundle coupling component includes saturating
Mirror, fiber optic bundle, fiber optic bundle clamper and five dimension translation stages；It is flat that the lens and the fiber optic bundle clamper are mounted on five dimension
Moving stage；
The lens are used for the optical coupling that issues the light source assembly into the fiber optic bundle；The fiber optic bundle clamper is for solid
The input terminal of the fixed fiber optic bundle, the output end of the fiber optic bundle are fixed on the imaging bracket.
4. photoacoustic tomography device according to claim 3, which is characterized in that the output end of the fiber optic bundle is fixed on
The center of the imaging cantilever tip.
5. photoacoustic tomography device according to claim 3, which is characterized in that the electronically controlled rotary table component includes electricity
Control turntable, Flexible Transmission hose and electronically controlled rotary table controller；The photoacoustic signal detector is soft by the Flexible Transmission
Pipe is connect with the electronically controlled rotary table；The electronically controlled rotary table controller is connect with the electronically controlled rotary table；
The electronically controlled rotary table is used to drive the photoacoustic signal detector along the concentric stroking by the Flexible Transmission hose
Slot movement；
The electronically controlled rotary table controller is for controlling the electronically controlled rotary table rotation.
6. photoacoustic tomography device according to claim 5, which is characterized in that the center of the electronically controlled rotary table opens up
There is through-hole, the fiber optic bundle passes through the through-hole and is fixed on the imaging bracket.
7. photoacoustic tomography device according to claim 1, which is characterized in that the signal acquisition component further includes letter
Number amplifier and data collecting card, the photoacoustic signal detector are connect with the signal amplifier, the signal amplifier with
The data collecting card connection；
The photoacoustic signal that the signal amplifier is used to detect the photoacoustic signal detector amplifies；
The amplified photoacoustic signal is transferred to described by the data collecting card for acquiring amplified photoacoustic signal
Signal processing component.
8. photoacoustic tomography device according to claim 1, which is characterized in that be provided with bone on the imaging bracket
Wax, the bone wax are used to the imaging bracket being fixed on the imaging position.
9. -8 any photoacoustic tomography device according to claim 1, which is characterized in that the photoacoustic signal detector
For miniature ultrasonic detector.
10. photoacoustic tomography device according to claim 9, which is characterized in that the inside of the imaging bracket is equipped with
Ultrasonic coupling agent.
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Cited By (1)
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| CN107069391A (en) * | 2017-02-10 | 2017-08-18 | 北京大学 | Femtosecond pulse modulator and the miniature two-photon microscopic imaging device with it |
| CN107692975A (en) * | 2017-10-26 | 2018-02-16 | 电子科技大学 | Three-dimensional optoacoustic laminated imaging device and method |
| CN108553080A (en) * | 2017-12-26 | 2018-09-21 | 天津大学 | A kind of stereoscan optoacoustic Jie's sight imaging system towards toy subcutaneous tumor |
| CN108606777A (en) * | 2018-03-28 | 2018-10-02 | 暨南大学 | Optoacoustic computed tomography system based on adjustable focus type fibre optical sensor |
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| CN111053534A (en) * | 2019-12-17 | 2020-04-24 | 电子科技大学 | Dynamic brain function bimodal imaging system based on fluorescence and photoacoustic tomography |
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