CN110469162B - Clean factory building integral structure for medicine production and factory building operation method - Google Patents
Clean factory building integral structure for medicine production and factory building operation method Download PDFInfo
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Abstract
The invention relates to a clean factory building integral structure and a factory building operation method for medical production, in particular to a clean factory building integral structure and a factory building operation method which are layered up and down and freely configured by standard clean production modules ('T-BLOC'), and the clean factory building integral structure and the factory building operation method are mainly applied to the field of pharmacy. The scheme of the invention mainly adopts a unified, non-segmentation and non-obstruction production hall, an upper layer structure and a lower layer structure which are mutually isolated, and a plurality of public system collecting channels at fixed positions are preset in advance, and the channels are matched with corresponding movable standard clean production modules. And a corresponding specific plant operation method. The invention has the advantages of good space utilization rate, effective isolation, convenient and flexible configuration of production space and low energy consumption.
Description
Technical Field
The invention relates to a clean factory building integral structure and a factory building operation method for medical production, in particular to a clean factory building integral structure and a factory building operation method which are layered up and down and freely configured by standard clean production modules ('T-BLOC'), and the clean factory building integral structure and the factory building operation method are mainly applied to the field of pharmacy.
Background
The existing biotechnological factory building planar design commonly adopts two schemes: 1. designing a factory building based on stainless steel production equipment; 2. factory buildings are designed based on disposable production equipment. The two plane design schemes divide the production into independent areas, such as a dressing area, a corridor, an upstream production area, a downstream production area and a filling area according to the biotechnological process steps and the pharmaceutical production specification requirements; the relative positions of the areas are fixed; according to the material transfer requirement, the production area contains long-distance corridor.
Based on the planar design, a heating ventilation and air conditioning system serving the production plant is positioned at one side of the plant; fresh air pipe, air supply pipe, return air pipe, exhaust pipe are very crowded in technology intermediate layer walking.
The disadvantages of these designs are therefore also very pronounced, in particular: 1. the operating rooms are generally designed to the largest area, resulting in excessive energy consumption associated with the air conditioner. 2. The production partition is fixed, which is not beneficial to expanding the production or increasing new products with changed processes. 3. The factory building is internally provided with a long corridor, and an area where an operator operates and walks is required to be arranged in a production room, so that space is wasted. 4. To avoid cross-contamination, each production zone can only produce one product at a time. 5. The air pipes in the technical interlayer are arranged in a staggered manner with the process water pipelines, the process air pipelines, the fire water pipelines and the cold and hot water pipelines, so that the overhaul is not facilitated.
In addition, the Chinese patent with the bulletin number of CN204402090U discloses a biomedical factory building structure for avoiding the intersection of people stream and logistics, and the routes of production personnel are designed in a three-dimensional way through a novel route organization form, so that the routes of production personnel and non-production personnel are completely independent in space. And an independent pollutant material exit channel is arranged, so that the risk of cross contamination among production personnel, clean materials and pollutant materials in a production area is reduced. The utility engineering area and other auxiliary production areas are shielded outside the production area, and a relatively concentrated utility engineering area is arranged, so that the utility engineering management cost can be saved, and independent access channels are arranged for the utility engineering, so that the utility engineering area is relatively isolated from production personnel, and adverse effects on the production area caused by operation and maintenance of the utility engineering area are avoided.
In addition, the Chinese patent application with publication number of CN101503916A discloses a modularized factory building structure, which relates to the structural design of a clean factory building of a multi-layer pharmaceutical enterprise. The factory building disclosed by the invention is composed of at least 2 floors, one floor is a comprehensive area (A), more than one floor is a production operation area (B), the production operation area (B) is composed of at least one modularized production area (3) and a visiting corridor (C) surrounding the production operation area, the modularized production area (3) and the visiting corridor (C) surrounding the production operation area are mutually independent, and the comprehensive area (A) is provided with an inlet (D), a dressing room and a shower room of each modularized production area (3). The modularized factory building structure provided by the invention has the advantages that the transportation of staff is most convenient, the walking distance is reduced, the energy consumption of an air conditioner is reduced, and the energy saving characteristic is embodied. And secondly, due to the design of the stairway and the courtyard, even if the stairway meets the requirement of fire control standard, the stairway can naturally collect light through the courtyard, so that the investment cost is reduced. The changing room and the shower room of the staff are arranged at one layer and at the interlayer position of each layer of stairwell, so that the staff in different production areas can enter the corresponding production areas most conveniently, and the using space between the floors is fully utilized. The annular visiting corridor does not cross with workshop production modules, disposable caps, masks and the like are not needed, and the cost of enterprises is reduced.
However, the two designs have drawbacks, and are particularly shown in the following: 1. each operation layer is provided with a plurality of columns or partition walls, and the utilization rate of the production hall is low. 2. The position between every two production workshops is fixed and cannot be adjusted according to the production requirement. 3. The function of the production workshop is single, and the production workshop cannot be flexibly arranged. 4. The area of the production space is fixed and cannot be increased or decreased according to actual conditions. 5. The clean production area is large, and the construction cost and the operation cost are high.
Disclosure of Invention
The invention aims to solve the technical problem of providing a clean factory building integral structure for medical production, which has the advantages of reasonable structural design, good space utilization, effective isolation, convenient and flexible configuration of production space and low energy consumption.
Another technical problem to be solved by the invention is to provide an operation method of the whole structure of the clean factory building for medical production.
The technical scheme adopted by the invention for solving the technical problems is that the clean factory building integral structure for medicine production comprises a process operation layer and a technical platform layer, wherein the process operation layer is a process production operation area, and the technical platform layer is an equipment and pipeline arrangement area, and the structure is characterized in that: also included is a method of manufacturing a semiconductor device,
The overhaul isolation interlayer is positioned between the process operation layer and the technical platform layer and can physically isolate the process operation layer and the technical platform layer;
The public system collecting channels are arranged on the overhaul isolation interlayer and the technical platform layer and integrate inlets and outlets of water, electricity and gas pipelines required by production;
The system comprises a standard clean production module ('T-BLOC'), wherein the standard clean production module is of a relatively closed structure and is provided with an independent ground wall surface and an independent top surface, and a public system access point corresponding to a public system collecting channel is arranged on the standard clean production module and independently corresponds to a public system collecting channel; and a sewage access point corresponding to a factory building drainage system is arranged below the standard clean production module on the ground of the process operation layer.
The overhaul isolation interlayer can physically isolate a process operation layer from a technical platform layer and provide a quick overhaul channel. The device is matched with the upper part of a standard clean production module, can provide a relatively closed overhaul space, and realizes quick overhaul under the condition of not affecting the clean production environment of a process operation layer.
The standard clean production module is of a relatively closed structure, is provided with an independent top surface, an independent ground surface and an independent wall surface, and is customized according to process requirements and a factory building structure.
The three-layer structure in the up-down direction is designed, so that the interference of equipment control, overhaul and other works on clean production is effectively isolated. And the whole production hall can be integrated together, and only production is performed in the standard clean production module by matching with the design of the standard clean production module. The warehouse space is delivered to the production hall, so that the area of the high clean space is effectively controlled, the construction and operation costs are reduced, and the energy consumption is also reduced. The arrangement of the public system access point and the public system collecting channel effectively integrates pipelines, and meanwhile, very important, the standard clean production module can move and increase among different public system collecting channels. Therefore, the production space can be reasonably configured, and the flexibility and the adaptability are increased.
A configurable public system collecting channel which can cover the whole process operation layer and is used for serving standard clean production modules in the process operation layer is arranged on the technical platform layer, the public system collecting channel is widely integrated with inlets and outlets of water, electricity and gas pipelines required by production, and expansion ports are reserved at a plurality of positions so as to meet the requirement of rapidly deploying new or moving the existing standard clean production modules according to the process requirements;
Further, a total dressing room is arranged in the process operation layer, and the total dressing room is arranged at an inlet of the process operation layer; the space of the process operation layer except for the total changing room forms a production hall, and the production hall is of a structure without columns. The structure without the post can integrate the areas of the whole hall together, and increase the utilization rate of the area of the production hall. The standard clean production module is matched with the standard clean production module so that the standard clean production module in the production hall can freely move and be adjusted according to the process requirement.
The main body of the process operation layer is a clean production hall, and is a non-upright all-steel-frame structure factory building which is convenient for standard clean production modules to move rapidly and has an area exceeding one thousand seven hundred square meters.
The arrangement of the total dressing room can intensively standardize the inlet and the outlet, and intensively disinfect and change clothes.
Further, the production hall of the invention is a grid structure. The grid structure not only can realize a pillar-free hall structure, but also has high structural stability and firmness. Of course, other post-free structures may be used.
Further, a hall suspended ceiling is arranged above the production hall and the total changing room, and the hall suspended ceiling separates a process operation layer and an overhaul isolation interlayer.
Furthermore, the overhaul isolation interlayer can accommodate access of overhaul personnel.
The hall ceiling is strong enough to support people to crawl or walk on the hall ceiling, and the hall ceiling is a clean board ceiling and can generate isolation effect. Meanwhile, the method meets the strict environmental requirements of the clean area and provides a maintenance space completely isolated from the production area.
Furthermore, the air conditioning units are arranged in the technical platform layer, each air conditioning unit independently corresponds to a standard clean production module, and an air pipe of each air conditioning unit is connected into a public system collecting channel.
The air conditioning unit comprises a plurality of air conditioners with efficient filtering systems. Each air conditioner independently corresponds to a standard clean production module, and an air pipe of the air conditioner unit is connected into a public system collecting channel.
Further, the outer wall of the standard clean production module is provided with a liquid input hole and/or a liquid output hole.
The liquid input hole and the liquid output hole are large-aperture holes, the aperture is generally 10 cm-20 cm, and the liquid input hole and the liquid output hole can be flexibly connected with pipelines or lines inside and outside a standard clean production module.
The arrangement of the liquid input hole and the liquid output hole further enriches the ways of entering and exiting the production workshops of production materials and finished semi-finished products, further ensures the clean module production of the standard clean production module, and simultaneously further ensures the convenience and the cleanliness of raw material supply.
Further, a standard clean production module suspended ceiling is arranged above the inside of the standard clean production module; the standard clean production module is provided with an independent people stream air lock and an independent logistics air lock. Typically at the side entry.
The other technical scheme adopted by the invention for solving the technical problems is an operation method of the whole structure of the clean factory building for medicine production: the method is characterized by comprising the following steps:
A. Arranging equipment and pipelines of various water, electricity, gas and air conditioning units on a technical platform layer, and concentrating interfaces of the equipment and the pipelines to each public system collecting channel;
B. a plurality of public system collecting channels are arranged at the upper part of the process operation layer; a plurality of drainage system drainage access points are arranged at the lower part of the process operation layer;
C. The standard clean production module is arranged below a public system collecting channel, and each public system collecting channel corresponds to a public system access point of the standard clean production module; maintaining the internal air pressure of each standard clean production module higher than the air pressure of the production hall;
D. The production personnel clean, disinfect and change clothes through the general changing room, and enter the production hall;
E. the production personnel entering the production hall clean, disinfect and change clothes according with the clean requirement of the standard clean production module through the people flow air gate of each standard clean production module, and carry out corresponding production work;
F. The production materials pass through a logistics air gate of each standard clean production module, are cleaned and sterilized according with the clean requirements of the standard clean production modules, and then enter the standard clean production modules for production;
G. the intermediate product or the final product produced in the standard clean production module is transported out of the standard functional module through a logistics air gate;
H. the final product is transported out through the production hall.
According to the operation method, in the production process, if liquid is required to be output or input, the liquid is processed through the liquid input hole or the liquid output hole of the standard clean production module; the electric wires in the standard clean production module can also be pulled out through the liquid input hole or the liquid output hole; the adjustment of production water electric or air conditioning equipment and parameters is carried out on a technical platform layer.
If equipment in a clean production hall is required to be used or liquid in a standard clean production module is output or input into the clean production hall or other standard clean production modules, the liquid can be connected and conveyed through large-aperture input/output holes arranged on the wall surface of the standard clean production module; the adjustment or maintenance of the production water electric or air conditioning equipment and parameters can be independently carried out on the technical platform layer, and the clean production environment and the clean production activity of the process operation layer are not affected.
Compared with the prior art, the invention has the following advantages and effects:
1. one layer is a process operation layer, the upper layer is a technical platform layer, an overhaul isolation interlayer is arranged between the process operation layer and the technical platform layer, and the three layers are designed in the vertical direction, so that the process operation layer and the technical platform layer are effectively isolated, and the influence and the damage of maintenance work on the clean production environment are reduced to the greatest extent.
2. In the production hall of the process operation layer, a plurality of standard clean production modules are arranged, only production is carried out in the standard clean production modules, no storage and material storage space exists, and the functions are provided by wall surface transmission holes of the standard clean production modules and the production hall. The method can limit the area of the controlled production area to the greatest extent, reduce the construction cost and the operation cost, greatly reduce the transportation of materials and equipment, improve the production efficiency and facilitate the better management of the controlled production area. That is, the design of the invention transfers the storage space of the production container from the standard clean production module to the production hall with lower clean level, and the area and the volume of the standard clean production module are greatly reduced, thereby reducing the energy consumption of the overall air conditioner, and simultaneously, the production container is placed in the production hall, thereby effectively utilizing the idle area in the production hall and improving the utilization rate of the overall factory building.
3. Public system collecting channels and corresponding drainage points are widely arranged in a clean production hall, and each public system collecting channel comprises energy sources (water, electricity and gas) and a high-efficiency filtering air conditioning system which are required by production and clean production environment control. The quick access of the standard clean production module can be accepted at any time. Because the volume of the standard clean production module is reduced, the dead weight is reduced, and the module can be easily moved, the standard clean production module is standard and uniform in size, the application of the module can be rearranged according to the needs in the future, and the positions of the standard clean production module can be rearranged according to the needs. Each standard clean production module can be flexibly arranged at a public system collecting channel. The space of the clean production hall without the upright post, the standard clean production module has small volume and widely arranged public system collecting channels, and the flexible movement and increase and decrease of each standard clean production module according to the process requirements in the clean production hall are comprehensively realized.
4. Various matched water, electricity and gas equipment and air conditioning systems are concentrated on a technical platform layer, and maintenance and installation are basically completed on the technical platform layer. The special maintenance condition can be finished in the maintenance isolation interlayer. The arrangement of the three-layer structure isolates the upper and lower operation spaces, and the influence on clean production is minimum.
5. Each standard clean production module is a relatively independent space and has a special air conditioning unit without cross-contamination with other modules. Can realize that each standard clean production module produces different products simultaneously. Each standard clean production module is independently provided with a people stream air lock and a logistics air lock, and is further isolated and independent.
6. Because the air conditioning unit in the technical interlayer is positioned in the middle of each functional module, and each standard clean production module only has one public system access point, all air pipes and water pipes are concentrated in a public system collecting channel, the interlayer is simply and orderly arranged, and the air conditioning unit is close to a technical platform, thereby being beneficial to maintenance.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions of the prior art, the drawings which are used in the description of the embodiments or the prior art will be briefly described, it being obvious that the drawings in the description below are only some embodiments of the invention, and that other drawings can be obtained according to these drawings without inventive faculty for a person skilled in the art.
Fig. 1 is a schematic cross-sectional view of the present invention.
FIG. 2 is a schematic top view of the process layer of the present invention.
Fig. 3 is a schematic view of a part of a perspective structure of the present invention.
Description of the reference numerals: the technology comprises a process operation layer 1, a technical platform layer 2, an overhaul isolation interlayer 3, a production hall 4, a general changing room 5, a standard clean production module 6, a people air brake 7, a logistics air brake 8, a hall ceiling 9, a technical platform floor 10, a public system access point 11, an air conditioning unit 12, a liquid input hole 13, a liquid output hole 14, a standard clean production module ceiling 15, a public system collecting channel 16, electric equipment 17 and water supply equipment 18.
Detailed Description
The present invention will be described in further detail with reference to the following examples, which are illustrative of the present invention and are not intended to limit the present invention thereto.
Example 1:
the following section of this embodiment describes a clean factory building overall structure for pharmaceutical production.
As shown in fig. 1 to 3, the main body of the whole clean factory building for pharmaceutical production of this embodiment is a three-layer structure building, which is a process operation layer 1, an overhaul isolation interlayer 3 and a technical platform layer 2 from bottom to top, and a clean hall ceiling 9 capable of being taken on people is arranged above the process operation layer 1 and is used for isolating the process operation layer 1 and the overhaul isolation interlayer 3. The process operation layer 1 is a place for carrying out clean production activities and is divided into a production hall 4 and a general dressing room 5. The overall dressing room 5 is located at the entrance and exit of the process operation layer 1 and is also the entrance and exit of the production hall 4. The rest of the process layer 1 constitutes the production hall 4 and is a large space integrated together. The production hall 4 adopts a column-free grid structure, namely a heavy steel grid structure, so that the space concentration of the production hall 4 is ensured and no obstruction exists. Of course, the grid structure may be used in the whole process operation layer 1. Moreover, other structures without columns can be adopted, so long as no barriers such as columns in the production hall 4 are ensured, and the movement of the standard clean production module 6 and the stacking and transportation of materials are mainly facilitated. The standard clean production module 6 is in actual use named "T-BLOC".
The upper part of the hall suspended ceiling 9 is provided with the overhaul isolation interlayer 3, the overhaul isolation interlayer 3 is matched with the upper part of the standard clean production module 6, and can provide a relatively closed overhaul space, thereby not only physically playing an isolating role, but also supporting one to two people for overhaul operation. The rapid maintenance is realized under the condition of not affecting the clean production environment of the process operation layer 1.
Above the service and maintenance isolation interlayer 3 is a technical platform floor 10 for separating the service and maintenance isolation interlayer 3 and the technical platform layer 2.
In the middle of the technical platform layer 2, all air conditioning units 12 serving the process operation layer 1 are centrally placed on the technical platform floor 10. The technical platform floor 10 has an overall reinforced structure due to the heavy weight of the air conditioning unit 12 and the vibration associated with operation.
Various water, electricity and gas equipment and pipelines required by medical clean production, such as an electric equipment 17 and a water supply equipment 18, are arranged on the technical platform layer 2. Five holes are formed in the technical platform floor 10, and five holes are formed in the corresponding positions of the same hall suspended ceiling 9. Five common system collection channels 16 are provided at the locations of the holes, and various pipes and wires are collected in these common system collection channels 16.
The technical platform layer 2 is provided with a configurable public system collecting channel 16 which can cover the whole process operation layer 1 and is used for serving the standard clean production module 6 in the process operation layer 1, the public system collecting channel 16 is widely integrated with inlets and outlets of water, electricity and gas pipelines required by production, and expansion ports can be reserved at a plurality of positions to meet the requirement of rapidly deploying new or moving the existing standard clean production module 6 according to the process requirements;
Corresponding sewer access points are also provided at the public system collection channel 16 corresponding to the ground of the large production hall 9. The technical platform layer 2 is an unclean production area, and the normal equipment installation, adjustment and maintenance are all developed in the unclean production area. The contact position of the public system collecting channel 16 and the technical platform floor slab 10 and the hall suspended ceiling 9 adopts a sealing mode, so that the relative isolation between the production hall 4 and the overhauling isolation interlayer 3 and the technical platform layer 2 is ensured. The lines of the air conditioning units 12 also connect to a common system collection channel 16, and likewise, one air conditioning unit 12 corresponds to one common system collection channel 16.
At a position below the common system collection channel 16 of the production hall 4, standard clean production modules 6 are relatively fixedly arranged, and in this embodiment, 3 standard clean production modules 6 are arranged in total. Respectively corresponding to three common system pooling channels 16. The other two temporarily unused common system pooling channels 16 may be temporarily closed to remain isolated. Each standard clean production module 6 is provided with a public system access point 11, the public system access point 11 is in butt joint with each public system collecting channel 16, and the standard clean production module 6 is small in size and light in weight, and is generally 66.5 square meters in area and 2.5 tons in weight.
The standard clean production module 6 is a relatively closed structure, has independent top surfaces, ground surfaces and wall surfaces, and is customized according to process requirements and matched with a factory building structure. The upper part of the standard clean production module 6 is provided with a public system access point 11 corresponding to the public system collecting channel 16, the public system access point 11 independently corresponds to one public system collecting channel 16, and the lower part of the standard clean production module 6 is provided with a sewer access point corresponding to a factory building drainage system.
When the production changes and needs to be adjusted, the standard clean production module 6 can be moved to the lower part of the other public system collecting channels 16 in a whole way and re-connected. It is also possible to supplement the standard clean production modules 6 and to provide 4 or 5 standard clean production modules 6 (possibly requiring the air conditioning unit 12 to be supplemented). Of course, the number of standard clean production modules 6 may be reduced as appropriate.
A standard clean production module suspended ceiling 15 is arranged above the inside of each standard clean production module 6, and a people stream air lock 7 and a logistics air lock 8 are arranged at the inlet and outlet of each standard clean production module 6 for the production personnel and the materials to enter and exit. The wall body of the standard clean production module 6 is also provided with a liquid input hole 13 and a liquid output hole 14, so that liquid production materials can be conveniently fed in and fed out, and the efficiency is further improved.
The following sections of this embodiment describe the operation of the foregoing clean building overall structure.
5 Public system collecting channels are arranged at corresponding positions on the overhaul isolation interlayer 3 and the technical platform layer 2;
Various water, electricity and gas equipment are arranged on the technical platform layer 2, and the water, electricity and gas equipment comprises an electric equipment 17, an air conditioning unit 12 and a water supply equipment 18; the lines of all the devices are centrally connected to a common system pooling channel 16.
Three standard clean production modules 6 are respectively arranged below the middle three public system collecting channels 16, and the public system access point 11 of each standard clean production module 6 corresponds to one public system collecting channel 16; and is connected with a corresponding sewage access point.
The production personnel enter the total changing room 5 through the inlet of the process operation layer 1, carry out preparation work such as cleaning, disinfection, changing clothes and the like in the total changing room 5, and enter the production hall 4;
the production personnel entering the production hall 4 perform cleaning and disinfection and dressing again through the people flow air gate 7 of each standard clean production module 6, and enter the corresponding standard clean production module 6 to perform production related work;
The production materials enter a production hall 4 for standby through an inlet of the process operation layer 1;
The production materials pass through the logistics air lock 8 of each standard clean production module 6, are cleaned and sterilized according with the clean requirement of the standard clean production module 6, and then enter the standard clean production module 6 for production.
The adjustment of production water electric or air conditioning equipment and parameters is carried out on a technical platform layer 2;
the produced intermediate product or final product is transported out of the standard clean production module 6 through the logistics air brake 8; the liquid can be output or input through the liquid input hole 13 or the liquid output hole 14 of the standard clean production module 6; meanwhile, some lines may also be accessed through the liquid input hole 13 or the liquid output hole 14. The aperture of the liquid input hole 13 or the liquid output hole 14 is 15cm.
The air pressure in the standard clean production module 6 is always higher than the air pressure in the production hall 4, so that the standard clean production module 6 can always keep the external positive pressure difference and keep clean.
If intermediate products exist, the intermediate products can also enter another standard clean production module 6 for production through a logistics air lock 8 or a liquid input hole 13 and a liquid output hole 14;
the production materials and the final products can be flexibly and freely piled up in the production hall 4, and the final products are transported out through the production hall 4.
General production overhauling and maintenance are carried out in the technical platform layer 2, and personnel can enter the overhauling isolation interlayer 3 for overhauling if necessary.
In the invention, the public system collecting channels 16 can flexibly design 4-12 according to the size of the production hall 4 and actual production requirements. The corresponding standard clean production modules 6 can also be arranged accordingly.
In the invention, the requirements of the production hall 4 on the cleanliness are relatively not particularly high, while the standard clean production module 6 is used as a production workshop, and the requirements of the production hall 4 and the standard clean production module 6 can be met through the heavy isolation of the standard clean production module suspended ceiling 15, the hall suspended ceiling 9, the overhaul isolation interlayer 3 and the technical platform floor 10. Meanwhile, a standard clean production module 6 corresponds to a public system collecting channel 16 and a group of air conditioning units 12, so that the clean production requirement is realized, and the cross contamination is avoided. Meanwhile, the power supply, the water supply and the energy supply are centralized, so that the energy consumption is reduced.
In the invention, each standard clean production module 6 only carries out the production of one product, further avoids cross contamination, and has more centralized and controllable production. One production shop is problematic and does not involve other workshops and production halls 4.
In the present invention, the air conditioning units 12 may also be disposed outside the entire structure, and be integrated into the public system collecting channel 16 and enter the standard clean production module 6 through the pipeline, so that only one group of air conditioning units 12 may be ensured to correspond to one standard clean production module 6, and in special cases, one group of air conditioning units 12 may also correspond to two standard clean production modules 6.
In the present invention, the air conditioning unit 12 may also be located outside the building or other suitable location, so long as the air duct of the air conditioning unit 12 is secured to be integrated into the common system collection duct 16. The air conditioning unit 12 may also be located on an exterior wall or other location if the strength of the location where the air conditioning unit 12 is located is sufficient.
In addition, the specific embodiments described in the present specification may differ in terms of parts, shapes of components, names, and the like. All equivalent or simple changes of the structure, characteristics and principle according to the inventive concept are included in the protection scope of the present invention. Those skilled in the art may make various modifications or additions to the described embodiments or substitutions in a similar manner without departing from the scope of the invention as defined in the accompanying claims.
Claims (10)
1. A clean factory building overall structure for medicine production contains technology operation layer and technical platform layer, technology operation layer is technology production operation region, technical platform layer is equipment, pipeline arrangement region, characterized by: also included is a method of manufacturing a semiconductor device,
An overhaul isolation interlayer between the process operation layer and the technical platform layer, the overhaul isolation interlayer being capable of physically isolating the process operation layer and the technical platform layer;
The public system collecting channels are arranged on the overhaul isolation interlayer and the technical platform layer and integrate inlets and outlets of water, electricity and gas pipelines required by production;
The standard clean production module is of a relatively closed structure and is provided with an independent ground wall surface and an independent top surface, and a public system access point corresponding to a public system collecting channel is arranged on the standard clean production module and independently corresponds to a public system collecting channel; and a sewage access point corresponding to a factory building drainage system is arranged below the standard clean production module on the ground of the process operation layer.
2. The clean building block structure for pharmaceutical production of claim 1, wherein: the process operation layer is internally provided with a total dressing room which is arranged at an inlet of the process operation layer; the space of the process operation layer except for the total changing room forms a production hall, and the production hall is of a structure without columns.
3. The clean building block structure for pharmaceutical production of claim 2, wherein: the production hall is of a grid structure.
4. The clean building block structure for pharmaceutical production of claim 2, wherein: the hall suspended ceiling is arranged above the production hall and the general changing room, and the hall suspended ceiling separates a process operation layer and an overhaul isolation interlayer.
5. The clean building block structure for pharmaceutical production of claim 1, wherein: the maintenance isolation interlayer can accommodate access of maintenance personnel.
6. The clean building block structure for pharmaceutical production of claim 1, wherein: the technical platform layer is provided with air conditioning units, each air conditioning unit independently corresponds to a standard clean production module, and an air pipe of the air conditioning unit is connected into a public system collecting channel.
7. The clean building block structure for pharmaceutical production of claim 1, wherein: the outer wall of the standard clean production module is provided with a liquid input hole and/or a liquid output hole.
8. The clean building block structure for pharmaceutical production of claim 1, wherein: a standard clean production module suspended ceiling is arranged above the inside of the standard clean production module; the standard clean production module is provided with an independent people stream air lock and an independent logistics air lock.
9. A method of operating a clean building monolith for pharmaceutical production according to any one of claims 1 to 8: the method is characterized in that:
A. Arranging equipment and pipelines of various water, electricity, gas and air conditioning units on a technical platform layer, and concentrating interfaces of the equipment and the pipelines to each public system collecting channel;
B. a plurality of public system collecting channels are arranged at the upper part of the process operation layer; a plurality of drainage system drainage access points are arranged at the lower part of the process operation layer;
C. The standard clean production module is arranged below a public system collecting channel, and each public system collecting channel corresponds to a public system access point of the standard clean production module; maintaining the internal air pressure of each standard clean production module higher than the air pressure of the production hall;
D. The production personnel clean, disinfect and change clothes through the general changing room, and enter the production hall;
E. the production personnel entering the production hall clean, disinfect and change clothes according with the clean requirement of the standard clean production module through the people flow air gate of each standard clean production module, and carry out corresponding production work;
F. The production materials pass through a logistics air gate of each standard clean production module, are cleaned and sterilized according with the clean requirements of the standard clean production modules, and then enter the standard clean production modules for production;
G. the intermediate product or the final product produced in the standard clean production module is transported out of the standard functional module through a logistics air gate;
H. the final product is transported out through the production hall.
10. The method of operation of claim 9, characterized by the steps of: in the production process, if the liquid is required to be output or input, the liquid is processed through a liquid input hole or a liquid output hole of a standard clean production module; the electric wires in the standard clean production module can also be pulled out through the liquid input hole or the liquid output hole; the adjustment of production water electric or air conditioning equipment and parameters is carried out on a technical platform layer.
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| CN111140046A (en) * | 2020-03-16 | 2020-05-12 | 河南森源电气股份有限公司 | Mask processing system |
| CN111827742A (en) * | 2020-07-30 | 2020-10-27 | 宜春市龙腾机械电气有限公司 | Whole-process integrated sterile production system for masks |
| CN115729179A (en) * | 2022-09-26 | 2023-03-03 | 华兰生物工程重庆有限公司 | Environment analysis and control system for pharmaceutical enterprise |
| CN116791854A (en) * | 2023-05-18 | 2023-09-22 | 中建三局第一建设(四川)有限责任公司 | Access channel system for clean operating rooms |
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