CN110403956A - A kind of preparation method of skin wound antibacterial agent - Google Patents

A kind of preparation method of skin wound antibacterial agent Download PDF

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Publication number
CN110403956A
CN110403956A CN201910820070.4A CN201910820070A CN110403956A CN 110403956 A CN110403956 A CN 110403956A CN 201910820070 A CN201910820070 A CN 201910820070A CN 110403956 A CN110403956 A CN 110403956A
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China
Prior art keywords
antibacterial agent
preparation
chlorine dioxide
skin wound
added
Prior art date
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Pending
Application number
CN201910820070.4A
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Chinese (zh)
Inventor
袁纯金
袁世杰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHAOGUAN LANWEI DISINFECTANT INDUSTRY Co Ltd
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SHAOGUAN LANWEI DISINFECTANT INDUSTRY Co Ltd
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Priority to CN201910820070.4A priority Critical patent/CN110403956A/en
Publication of CN110403956A publication Critical patent/CN110403956A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/24—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients to enhance the sticking of the active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a kind of preparation methods of skin wound antibacterial agent, and processing step is: sodium carbonate liquor and sodium chlorite solution is first made；It is sufficiently mixed hydrochloric acid solution with obtained sodium chlorite solution, produces chlorine dioxide, be added through sodium carbonate liquor made from the first step, stabilizing chlorine dioxide finished product is made；Be added into chlorine dioxide citric acid activated dose, pure water, glycerol carry out synthesis preparation, the chlorine dioxide antibacterial agent for being 10-12 mg/L containing weight percent concentration is made, it is stronger that antibacterial agent surface is attached with glycerol adhesive force, while can slow down evaporation rate.The antibacterial agent produced has the characteristics that adhesive force is strong, not volatile, smell is small.

Description

A kind of preparation method of skin wound antibacterial agent
Technical field
The invention belongs to sterile products production technical fields, are related to a kind of pair of body surface or exogenous injury of human body inflammation and vulva Red and swollen itch carries out disinfection and removes the preparation method of the skin wound antibacterial agent of peculiar smell.
Background technique
Currently, thimerosal various types used by China's health and environmental protection administration, but the effect of these thimerosals has Limit, and most of also side effect.The product taste designed before us is larger, and assimilation effect is bad, easily directly volatilizees, leads Product efficacy is caused to be difficult to realize.
Summary of the invention
In order to overcome the disadvantages mentioned above of the prior art, the present invention provides a kind of preparation method of skin wound antibacterial agent, raw The antibacterial agent that output is come has the characteristics that adhesive force is strong, not volatile, smell is small.
The present invention solves technical method used by its technical problem: a kind of preparation method of skin wound antibacterial agent, Processing step is:
The first step is the preparation of raw material:
The sodium carbonate and water of 60-80kg is added in 25 DEG C -30 DEG C of tanks 1, using Multi-impeller stirring rod mixing 2 hours, together When 55 °C -75 °C are gradually warming up on the period, static half an hour at high temperature, it is the stable carbonic acid of 60-80% that concentration, which is made, Sodium solution；
The sodium chlorite and water of 85-98kg are added in 25 DEG C -30 DEG C of temperature of tank 2, weight is made after agitated dissolution 2 hours Amount percent concentration is 3%-4% sodium chlorite solution；
Second step is the preparation of stabilizing chlorine dioxide:
Into the first step, tank 2 enters hydrochloric acid solution appropriate, is sufficiently mixed hydrochloric acid solution with obtained sodium chlorite solution, control It is normal temperature and pressure in tank；Chlorine dioxide is produced after hybrid reaction, and chlorine dioxide is pumped by the bleed-off passage of tank 2 and is inhaled It in closed cans, and is added into tourie through sodium carbonate liquor made from the first step, after absorbing 8 hours, stabilized chlorine is made Chlorine finished product；
Third step is the preparation of Antibacterial Products:
Be added in through chlorine dioxide obtained by second step citric acid activated dose, pure water, glycerol carry out synthesis preparation, be made and contain Having weight percent concentration is the chlorine dioxide antibacterial agent of 10-12 mg/L, and it is stronger that antibacterial agent surface is attached with glycerol adhesive force, Evaporation rate can be slowed down simultaneously.
It further, is normal pressure and temperature in the tourie.
Further, in the antibacterial agent finished product weight percent concentration of arsenic less than 0.2, heavy metal in terms of lead For weight percent concentration less than 2.0, the pH value of antibacterial agent finished product is 6-8.
Further, each substance weight percentage in the third step are as follows: pure water 94.8%, glycerol 5%, chlorine dioxide 0.1%, activator 0.1%.
Further, the citric acid activated dose of food-grade citric acid generated for Weifang Ensign Industry Co., Ltd,.
The beneficial effects of the present invention are: can quickly kill diplococcus, large intestine using present invention antibacterial agent produced Bacillus, staphylococcus aureus, Candida albicans, withered grass gemma virus, hepatitis B, common cold virus, fungi, mould and propagation Property pathogenic bacteria；This product is colourless, it is tasteless, nontoxic, without secondary pollution, do not develop drug resistance, to eyes, skin, respiratory mucosa It is non-stimulated, it is a kind of environment-friendly products, can be used for body surface, wound inflammation and the disinfection of vulva redness itch, remove peculiar smell, have The features such as adhesive force is not strong, volatile, smell is small.
Detailed description of the invention
Fig. 1 is present invention process flow diagram.
Specific embodiment
Present invention will be further explained below with reference to the attached drawings and examples.
Referring to Fig. 1, a kind of preparation method of skin wound antibacterial agent, processing step is:
The first step is the preparation of raw material:
The sodium carbonate and water of 60-80kg is added in 25 DEG C -30 DEG C of tanks 1, using Multi-impeller stirring rod mixing 2 hours, together When 55 °C -75 °C are gradually warming up on the period, static half an hour at high temperature, it is the stable carbonic acid of 60-80% that concentration, which is made, Sodium solution；
The sodium chlorite and water of 85-98kg are added in 25 DEG C -30 DEG C of temperature of tank 2, weight is made after agitated dissolution 2 hours Amount percent concentration is 3%-4% sodium chlorite solution；
Second step is the preparation of stabilizing chlorine dioxide:
Into the first step, tank 2 enters hydrochloric acid solution appropriate, is sufficiently mixed hydrochloric acid solution with obtained sodium chlorite solution, control It is normal temperature and pressure in tank；Chlorine dioxide is produced after hybrid reaction, is pumped into chlorine dioxide often by the bleed-off passage of tank 2 It in the tourie of normal pressure and temperature, and is added into tourie through sodium carbonate liquor made from the first step, after absorbing 8 hours, is made Stabilizing chlorine dioxide finished product；
Third step is the preparation of Antibacterial Products:
To pure water 94.8%, glycerol 5% are added in 0.1% chlorine dioxide obtained by second step, activator 0.1% carries out synthesis and matches The chlorine dioxide antibacterial agent for being 10-12 mg/L containing weight percent concentration is made in system, and it is attached that antibacterial agent surface is attached with glycerol Put forth effort stronger, while evaporation rate can be slowed down；The weight percent concentration of arsenic is less than 0.2 in antibacterial agent finished product, in terms of lead For the weight percent concentration of heavy metal less than 2.0, the pH value of antibacterial agent finished product is 6-8
The above is only a preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-described embodiment, All technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art For those of ordinary skill, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications are also answered It is considered as protection scope of the present invention.

Claims (5)

1. a kind of preparation method of skin wound antibacterial agent, it is characterised in that processing step is:
The first step is the preparation of raw material:
The sodium carbonate and water of 60-80kg is added in 25 DEG C -30 DEG C of tanks 1, using Multi-impeller stirring rod mixing 2 hours, together When 55 °C -75 °C are gradually warming up on the period, static half an hour at high temperature, it is the stable carbonic acid of 60-80% that concentration, which is made, Sodium solution；
The sodium chlorite and water of 85-98kg are added in 25 DEG C -30 DEG C of temperature of tank 2, weight is made after agitated dissolution 2 hours Amount percent concentration is 3%-4% sodium chlorite solution；
Second step is the preparation of stabilizing chlorine dioxide:
Into the first step, tank 2 enters hydrochloric acid solution appropriate, is sufficiently mixed hydrochloric acid solution with obtained sodium chlorite solution, control It is normal temperature and pressure in tank；Chlorine dioxide is produced after hybrid reaction, and chlorine dioxide is pumped by the bleed-off passage of tank 2 and is inhaled It in closed cans, and is added into tourie through sodium carbonate liquor made from the first step, after absorbing 8 hours, stabilized chlorine is made Chlorine finished product；
Third step is the preparation of Antibacterial Products:
Be added in through chlorine dioxide obtained by second step citric acid activated dose, pure water, glycerol carry out synthesis preparation, be made and contain Having weight percent concentration is the chlorine dioxide antibacterial agent of 10-12 mg/L, and it is stronger that antibacterial agent surface is attached with glycerol adhesive force, Evaporation rate can be slowed down simultaneously.
2. a kind of preparation method of skin wound antibacterial agent as described in claim 1, it is characterised in that: be normal in the tourie Normal pressure and temperature.
3. a kind of preparation method of skin wound antibacterial agent as described in claim 1, it is characterised in that:
The weight percent concentration of arsenic is less than 0.2 in the antibacterial agent finished product, the weight percent concentration of the heavy metal in terms of lead Less than 2.0, the pH value of antibacterial agent finished product is 6-8.
4. a kind of preparation method of skin wound antibacterial agent as described in claim 1, it is characterised in that: each object in the third step Matter weight percent are as follows: pure water 94.8%, glycerol 5%, chlorine dioxide 0.1%, activator 0.1%.
5. a kind of preparation method of skin wound antibacterial agent as described in claim 1, it is characterised in that: citric acid activated dose is the Weihe River The food-grade citric acid that the pavilion Fang Ying Industrial Co., Ltd. generates.
CN201910820070.4A 2019-08-31 2019-08-31 A kind of preparation method of skin wound antibacterial agent Pending CN110403956A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910820070.4A CN110403956A (en) 2019-08-31 2019-08-31 A kind of preparation method of skin wound antibacterial agent

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101658397A (en) * 2009-09-08 2010-03-03 北京欧凯纳斯科技有限公司 Functional wipes containing chlorine dioxide and application thereof
CN101766543A (en) * 2010-02-10 2010-07-07 北京欧凯纳斯科技有限公司 Hand sanitizer containing chlorine dioxide
CN102091275A (en) * 2010-12-22 2011-06-15 韶关蓝威消毒药业有限公司 Preparation method of vaginal antibacterial flushing fluid
CN102090417A (en) * 2010-12-22 2011-06-15 韶关蓝威消毒药业有限公司 Preparation method of living disinfectant
CN102626104A (en) * 2012-03-22 2012-08-08 广东环凯微生物科技有限公司 Stabilized chlorine dioxide disinfection solution and its preparation method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101658397A (en) * 2009-09-08 2010-03-03 北京欧凯纳斯科技有限公司 Functional wipes containing chlorine dioxide and application thereof
CN101766543A (en) * 2010-02-10 2010-07-07 北京欧凯纳斯科技有限公司 Hand sanitizer containing chlorine dioxide
CN102091275A (en) * 2010-12-22 2011-06-15 韶关蓝威消毒药业有限公司 Preparation method of vaginal antibacterial flushing fluid
CN102090417A (en) * 2010-12-22 2011-06-15 韶关蓝威消毒药业有限公司 Preparation method of living disinfectant
CN102626104A (en) * 2012-03-22 2012-08-08 广东环凯微生物科技有限公司 Stabilized chlorine dioxide disinfection solution and its preparation method

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
张流波等主编: "《医学消毒学最新进展》", 31 December 2015, 人民军医出版社 *
沈阳药学院主编: "《药剂学》", 31 May 1980, 人民卫生出版社 *
薛广波主编: "《现代消毒学》", 31 July 2002, 人民军医出版社 *

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