CN110389163A - Noninvasive dynamics monitoring device based on multisensor pixel array - Google Patents
Noninvasive dynamics monitoring device based on multisensor pixel array Download PDFInfo
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1477—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means non-invasive
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- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
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- G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
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Abstract
The present invention relates to noninvasive dynamics monitorings.According to an exemplary embodiment, a kind of noninvasive dynamics monitoring device may include the array of multiple sensor pixels, each sensor pixel includes extracting electrode and detecting electrode, electrode is extracted to be used to permeate by reverse ion through user's skin extraction glucose, detecting electrode is used to detect the concentration of extracted glucose by electrochemical method, wherein, the array configuration of the multiple sensor pixel is when being attached on user's skin surface, at least one sensor pixel covers at least one hair follicle of user's skin and glucose is extracted and detected by it.Blood sugar test device structure of the invention is simple, and blood glucose extraction and detection can be carried out for hair follicle, significantly improve percutaneous blood glucose extraction and detection efficiency, and significantly improve the signal-to-noise ratio of blood sugar test process, to realize accurate blood sugar test in the case where not needing additional calibration operation.
Description
Technical field
Present invention relates generally to blood sugar test field, more specifically it relates to a kind of based on multisensor pixel array
Noninvasive dynamics monitoring device can realize the noninvasive dynamics monitoring of pinpoint accuracy in simple structure.
Background technique
Diabetes are inner-sphere reorganization energies most commonly seen in the world." Chinese residents nourishment and chronic disease status report
(2015) " it shows, 18 years old or more maturity-onset diabetes illness rate is 9.7%.China becomes incontrovertible the first big country of diabetes,
And have the tendency that rising year by year.
In diabetes patient, there is the number of invasive blood sugar instrument more than 50,000,000 people using tradition, blood glucose meter test paper is per capita
Yearization usage amount about 180, needing the blood glucose meter test paper consumed every year is about 9,000,000,000.At present since social life pressure is big,
Eating good things, it is few to move, and often stays up late, the pollution of excessive Smoking And Drinking and ecological environment, causes the presence of a large amount of sugar in compatriots
Urinate sick potential patient.Therefore, correct diagnosing and treating diabetes have a very important significance.
Diabetic will often carry out blood sugar concentration chemical examination during diagnosis and treatment, so that medical worker is well understood in time
The effect for the treatment of.But continually blood drawing has many drawbacks, has not only increased the danger of infection, but also cause suffering to patient, has returned doctor
Business personnel bring certain pressure.
Therefore, how to realize that noninvasive dynamics monitoring becomes the direction of researcher's effort for it.In order to change this situation,
Abroad in Recent Years is actively studying the non-damage determination method of blood sugar concentration, including uses near infrared spectrum and Raman light
Spectral technology carries out blood sugar monitoring.These method spectral signal-noise ratios are low, thus low using the accuracy of above method measurement blood glucose value.
It is permeated using percutaneous reverse ion in addition, somebody proposes to extract and detect blood glucose, equally exists detection signal noise
Than low problem, and longer extraction time is needed, detection efficiency is lower.
Therefore, it is still necessary to which a kind of noninvasive dynamics monitoring technology can efficiently and accurately detect blood sugar concentration.
Summary of the invention
To solve one or more of this field above and other technical problem, it is made that the present invention.
According to an exemplary embodiment, a kind of noninvasive dynamics monitoring device may include the array of multiple sensor pixels, often
A sensor pixel includes: extraction electrode, for being permeated by reverse ion through user's skin extraction glucose；And detection electricity
Pole, for detecting the concentration of extracted glucose by electrochemical method, wherein the array of the multiple sensor pixel is matched
Be set to when being attached on user's skin surface, at least one sensor pixel cover user's skin at least one hair follicle and
Glucose is extracted and detected by it.
In some instances, the noninvasive dynamics monitoring device further includes the battle array for supporting the multiple sensor pixel
The substrate of column.
In some instances, the substrate is flexible substrate.
In some instances, the extraction electrode includes anode and cathode, be used in user's skin be formed reversely from
Sub- infiltration lane is to extract glucose.The detecting electrode includes reference electrode, working electrode and to electrode, passes through electrochemistry
It reacts to detect the concentration of extracted glucose.The cathode and described same electrode can be to electrode.The anode packet
It includes Ag, the cathode, the reference electrode and described Ag/AgCl is each included to electrode.
In some instances, the extraction electrode of two adjacent sensor pixels is used separately as anode and cathode, for
Reverse ion infiltration lane is formed in the skin of family to extract glucose.The detecting electrode include reference electrode, working electrode and
To electrode, the concentration of extracted glucose is detected by electrochemical reaction.The extraction electrode and it is described can to electrode
To be same electrode.The extraction electrode, the reference electrode and described Ag/AgCl is each included to electrode.
In some instances, the working electrode includes: layer of precious metal；Catalyst on the layer of precious metal is set
Layer；And the glucose oxidase layer on the catalyst layer is set, the glucose oxidase layer is catalyzed extracted Portugal
The oxidation reaction of grape sugar is to generate hydrogen peroxide, and the decomposition of the catalyst layer catalyzing hydrogen peroxide is to generate kinetic current.
In some instances, the working electrode includes: the graphene layer with noble metal nano particles；And setting exists
Glucose oxidase layer on the graphene layer, the glucose oxidase layer are catalyzed the oxidation reaction of extracted glucose
To generate hydrogen peroxide, the decomposition of the noble metal nano particles layer catalyzing hydrogen peroxide is to generate kinetic current.
In some instances, the working electrode includes transition metal oxide layer.
In some instances, the transition metal oxide layer includes the compound of transition metal oxide.
In some instances, the transition metal oxide includes nickel oxide, tin oxide and indium oxide.
In some instances, the transition metal oxide layer has porous structure.
In some instances, the array configuration of the multiple sensor pixel be when being attached on user's skin surface,
At least one hair follicle of detecting electrode covering user's skin of at least one sensor pixel.
In some instances, the array configuration of the multiple sensor pixel be when being attached on user's skin surface,
At least one hair follicle of working electrode covering user's skin of the detecting electrode of at least one sensor pixel.
In some instances, in each sensor pixel, the area of the working electrode is greater than other any electrodes
Area.
In some instances, the array configuration of the multiple sensor pixel is that the area of wherein each sensor pixel exists
1mm2To 80mm2Between, preferably in 2mm2To 50mm2Between, more preferably in 3mm2To 20mm2Between, more preferably exist
4mm2To 9mm2Between.
In some instances, the array configuration of the multiple sensor pixel is matrix pattern, honeycomb pattern or concentric circles
Pattern.
In some instances, the array configuration of the multiple sensor pixel be include at least four sensor pixel, preferably
Ground at least 16 sensor pixels, more preferably at least 36 sensor pixels, more preferably at least 64 sensor pixels.
In some instances, the noninvasive dynamics monitoring device further include: data processing unit, for each sensor
The detection signal generated when the concentration of the extracted glucose of pixel detection is handled, with the dense of the extracted glucose of determination
Degree.
In some instances, the data processing unit includes memory, and storage is defined glucose in the memory
The calibration curve of relationship between concentration and detection electric current, the data processing unit are examined using the calibration curve to calculate
The concentration of glucose measured.
In some instances, the data processing unit is configured to from the detection signal that each sensor pixel provides really
Fixed effective detection signal, the effective detection signal are the detection letters for covering the sensor pixel of at least one hair follicle and generating
Number.
In some instances, the data processing unit is additionally configured to the sensor picture that selection generates effective detection signal
Usually repeat the extraction and detection of glucose.
In some instances, the array configuration of the multiple sensor pixel be when being attached on user's skin surface,
At least one sensor pixel covers the single hair follicle of user's skin, and the data processing unit is configured to each sensor
The detection signal that pixel provides determines the hair follicle number of each sensor pixel covering.
It can be seen from the above technical proposal that the embodiment provides a kind of noninvasive dynamics monitoring device, benefit
With the array of sensor pixel by Reverse iontophoresis and by means of human body hair follicle come from human body glucose to skin
Surface, and glucose is detected in human skin surface by electrochemical reaction, current signal relevant to blood sugar concentration is obtained,
To obtain blood sugar concentration.By above-mentioned workflow it can be found that the noninvasive dynamics monitoring device do not need to damage it is to be measured
Object can carry out the high efficiency extraction and detection of object blood glucose to be measured, realize the purpose of noninvasive dynamics monitoring.
In addition, the noninvasive dynamics monitoring device detects glucose using electrochemical reaction, glucose has specificity,
Eliminate a large amount of interference in detection process.Therefore, which realizes accurately noninvasive dynamics monitoring.
Detailed description of the invention
The embodiment of the present application is described in more detail in conjunction with the accompanying drawings, the above-mentioned and other purposes of the application,
Feature and advantage will be apparent.Attached drawing is used to provide to further understand the embodiment of the present application, and constitutes explanation
A part of book is used to explain the application together with the embodiment of the present application, does not constitute the limitation to the application.In the accompanying drawings,
The same or similar reference label typically represents the same or similar element.
Fig. 1 is the structural representation according to the sensor pixel array of the noninvasive dynamics monitoring device of one embodiment of the application
Figure；
Fig. 2 is the operation principle schematic diagram according to the noninvasive dynamics monitoring device of one embodiment of the application；
Fig. 3 is the structural representation according to the sensor pixel array of the noninvasive dynamics monitoring device of another embodiment of the application
Figure；
Fig. 4 is to be illustrated according to the layout of the sensor pixel array of the noninvasive dynamics monitoring device of another embodiment of the application
Figure；
Fig. 5 is the wearing structural schematic diagram according to the noninvasive dynamics monitoring device of one embodiment of the application；And
Fig. 6 is the wearing structural schematic diagram according to the noninvasive dynamics monitoring device of another embodiment of the application.
Specific embodiment
In the following, example embodiment according to the application will be described in detail by referring to the drawings.Obviously, described embodiment is only
It is only a part of the embodiment of the application, rather than the whole embodiments of the application, it should be appreciated that the application is not by described herein
The limitation of example embodiment.
Noninvasive dynamics monitoring device of the invention includes the array of multiple sensor pixels, and Fig. 1 is schematically shown according to one
The structure of the sensor pixel array of embodiment.As shown in Figure 1, the array 100 of sensor pixel may include multiple sensor pictures
Element 110, each sensor pixel 110 may be formed on substrate 120 and be supported by.Substrate 120 can be flexible substrate, such as
It is formed by the plastics or resin of such as PET etc.Each sensor pixel 110 includes for being permeated by reverse ion through user
The extraction electrode of skin extraction glucose, and the detection of the concentration for detecting extracted glucose by electrochemical method
Electrode.In the embodiment shown in fig. 1, each sensor pixel 110 may include electrode 111,112,113 and 114.It is extracting
When, electrode 111 and electrode 114 are used as extraction electrode together, such as electrode 111 is cathode, and electrode 114 is anode, in user
The channel of Reverse iontophoresis is established in skin, to extracting glucose to skin surface.Cathode 111 can be Ag/AgCl
Electrode, anode 114 can be Ag electrode.Ag/AgCl electrode includes the mixture of Ag and AgCl.When detecting, electrode 111, electricity
Pole 112 and electrode 113 can be used as detecting electrode together, such as electrode 111 can be used as to electrode, and electrode 112 can be used as work electricity
Pole, electrode 113 can be used as reference electrode, they constitute the three-electrode system of electrochemical reaction, to pass through electrochemical method pair
It extracts to the concentration of glucose of skin surface and is detected.To electrode 111 and reference electrode 113 or Ag/AgCl electrode.
It should be noted that electrode 111 be also used as cathode when extracting and when detection to electrode, i.e. cathode and be same electrode to electrode, but
It is cathode and individual electrode to be also possible to electrode it should be understood that in further embodiments.
Fig. 2 shows the operation principle schematic diagrams of the noninvasive dynamics monitoring device of Fig. 1.As shown in Fig. 2, in use, can be with
The noninvasive dynamics monitoring device of Fig. 1 is attached on user's skin, such as on the skin of arm, the back of the hand etc..In some implementations
In example, it is preferable that make electrode side skin-proximal, and 120 side of substrate is opposite side.In human body, in blood vessel and tissue fluid
Glucose by resorption process and process can be refiltered exchange each other, concentration is of substantially equal.Of the invention is noninvasive
Blood sugar detection apparatus can main migration path by human body hair follicle 410 as glucose, a large amount of glucose are out of human body through hair
Capsule is migrated to skin surface.Then, the electrochemical reaction three-electrode system constituted using electrode 111, electrode 112 and electrode 113,
It is detected by concentration of glucose of the electrochemical method to extraction to skin surface.
Through research, the inventor has found that the percutaneous extraction channel of blood sugar for human body include it is a variety of, typically comprise across cell
The extractability of channel, intercellular channel and hair follicle channels, different channels is widely different.Hair follicle is as the angle for penetrating skin
Matter layer, epidermis and corium, the natural lane for the hypodermal layer that goes directly, have excellent glucose extractability, logical much larger than across cell
Road and intercellular channel.Moreover, each hair follicle all has similar structure substantially, therefore the hair follicle of the same area has basic phase
Same glucose extractability.It is found in view of the studies above, noninvasive dynamics monitoring device of the invention is designed to for hair follicle
Non-invasively to extract and detect the intracorporal blood glucose of people.Specifically, multisensor pixel array 100, which is configured to work as, is attached to user
When on skin surface, at least one sensor pixel 110 cover user's skin at least one hair follicle, and by its extraction with
Detect glucose.Preferably, the detecting electrode of sensor pixel 110 covers hair follicle, it is highly preferred that the inspection of sensor pixel 110
The working electrode 112 surveyed in electrode covers hair follicle, to directly detect to the glucose extracted by hair follicle.
To achieve the goals above, the present inventor has carried out meticulous design to multisensor pixel array 100.The present invention
People's discovery, the area of each sensor pixel 110 are answered sufficiently small to carry out glucose extraction and inspection on the scale of hair follicle size
It surveys.It when the area of sensor pixel 110 is very big, is not only extracted by hair follicle, but also in the area bigger than hair follicle
In extracted by across cell channel and intercellular channel.The extractability of across cell channel and intercellular channel is to be far below
The extractability of hair follicle, to be diluted by the concentration of glucose that hair follicle extracts, long time is needed to complete to extract
And detection, cause detection efficiency low, and detection accuracy is not high.On the contrary, the area when sensor pixel 110 is sufficiently small with main
It, can be expeditiously complete due to the excellent glucose extractability of hair follicle channels when extracting and detecting for hair follicle
It extracts and detects at glucose, and can reduce and interfered by other Path Migration brings, to effectively promote the letter of measurement
It makes an uproar and compares, be greatly improved detection accuracy, can compare favourably with conventional finger blood detection mode.Certainly, sensor pixel 110
Area can not be too small, otherwise cannot cover hair follicle, nor be conducive to production.In some embodiments, each sensing
The area of device pixel 110 can be in 1mm2To 80mm2Between, preferably in 2mm2To 50mm2Between, more preferably in 3mm2It arrives
20mm2Between, more preferably in 4mm2To 9mm2Between.Wherein, the area of sensor pixel 110 is in 3mm2To 20mm2Between, it is excellent
Selection of land is in 4mm2To 9mm2Between, it is that very advantageously, can ensure that at least one sensor pixel 110 covers individually substantially
The advantages of (only one) hair follicle, this embodiment, will be described in further detail below.
It is appreciated that the number of the sensor pixel 110 in multisensor pixel array 100 is bigger, can also improve at least
One sensor pixel 110 covers the probability of at least one (or only one) hair follicle.In some embodiment of the invention, more sensings
Device pixel array 100 may include at least four sensor pixel, preferably at least 16 sensor pixels, more preferably at least 36
A sensor pixel, more preferably at least 64 sensor pixels.Consider from factors such as costs, multisensor pixel array 100
In the number of sensor pixel 110 can be at 200 hereinafter, preferably at 150 hereinafter, more preferably at 100 or less.
It is further appreciated that the average distance between the distance between sensor pixel 110 preferably smaller than hair follicle, such as can be with
Less than 8mm, preferably less than 5mm, even more preferably less than 3mm.In addition, the distance between sensor pixel 110 can be greater than
0.2mm, preferably more than 0.5mm, more preferably larger than 0.8mm.As described above,
When detection, the working electrode 112 in detecting electrode lures that electrochemical reaction occurs for extracted glucose into, thus raw
At detection electric current corresponding with concentration of glucose.It is preferred that multisensor pixel array 100 is configured at least one sensing
The working electrode 112 of device pixel 110 covers at least one (or only one) hair follicle.For this purpose, in some embodiments, it can be by work
Make electrode 112 and be designed as the area that its area is greater than other any electrodes, such as working electrode 112 can be designed as its area
Greater than the sum of the area of the every other electrode in sensor pixel.
Computer simulation results show by configuring multisensor pixel array 100 as described above, it can be ensured that at least
One sensor pixel 110, perhaps preferably its detecting electrode or the working electrode more preferably in detecting electrode, covering
At least one hair follicle of user's skin, or preferably single hair follicle.
Working electrode 112 can come to carry out Electrochemical Detection to extracted glucose in several ways.In some implementations
In example, working electrode 112 may include graphene layer, and surface can be attached with the nano particle of catalyst, such as noble metal is received
Rice grain, Pt nanoparticle, gold nano grain etc..Graphene layer has excellent electric conductivity and flexibility, therefore is used as
The preferred material of working electrode 112 may be implemented the perfection with human skin and attach.Working electrode 112 further includes being arranged in stone
Glucose oxidase layer on black alkene layer, glucose oxidase layer side directly connects with human skin when being attached on human skin
Touching.Glucose oxidase can be catalyzed the oxidation reaction for being extracted into the glucose of skin surface to generate hydrogen peroxide, peroxide
Changing hydrogen can be catalytically decomposed again by catalyst nano-particles such as Pt nanoparticle.In above-mentioned electrochemical reaction process, generate with
The relevant kinetic current of the concentration of glucose of human body surface may thereby determine that the intracorporal blood sugar concentration of people.
In further embodiments, working electrode 112 may include layer of precious metal such as layer gold.Layer gold can be formed compared with
It is thin, to also have good flexibility.Working electrode 112 may also include the catalyst layer being arranged on layer of precious metal, Yi Jishe
Set the glucose oxidase layer on catalyst layer.For example, layer of precious metal can by specially treated with roughened surface,
To for example Prussian blue roughened surface that can be attached to layer of precious metal well with glucose oxidase layer of catalyst layer
On.The working principle of such working electrode 112 is similar with embodiment described above.Specifically, glucose oxidase can
Be catalyzed be extracted into skin surface glucose oxidation reaction to generate hydrogen peroxide, hydrogen peroxide again can be by catalyst
For example Prussian blue catalytic decomposition of layer.In above-mentioned electrochemical reaction process, generate relevant to the concentration of glucose of human body surface
Kinetic current may thereby determine that the intracorporal blood sugar concentration of people.
In further embodiments, working electrode 112 may include transition metal oxide electrode.Transition metal oxide electricity
Pole may include the transition metal oxide of such as nickel oxide, copper oxide etc, also may include the compound of transition metal oxide
The mixture of object, such as nickel oxide, tin oxide and indium oxide etc..Such transition metal oxide electrode has porous structure,
It can directly be catalyzed the electrochemical reaction of glucose with high specific area.In the working electrode 112, it may not be necessary to make
It is simpler with glucose oxidase, therefore in structure, and can solve the problem of glucose oxidase is easy inactivation, Ke Yichang
Time keeps detection activity, is conducive to long-term lasting detection.It should be understood that in the present embodiment, working electrode 112 can also wrap
The substrate for carrying transition metal oxide is included, which can be the transition metal material being not yet oxidized.When in use,
The use environment of such working electrode 112 is preferably adapted for transition metal oxide and is catalyzed, such as use environment can be
Alkaline environment including OH-.
Fig. 3 is the structural representation according to the sensor pixel array of the noninvasive dynamics monitoring device of another embodiment of the application
Figure.As can be seen that the electrode structure and Fig. 2 of the sensor pixel of Fig. 3 are different.It, can be by the electrode knot of Fig. 2 in order to simple
Structure is known as four electrode structures, i.e., each sensor pixel includes four electrodes, and the structure of Fig. 3 is known as three-electrode structure, i.e.,
Each sensor pixel includes three electrodes.
As shown in figure 3, the multisensor pixel array 100 of the noninvasive dynamics monitoring device of the present embodiment includes multiple sensings
Device pixel 110, each sensor pixel 110 include electrode 111,112 and 113.When work, a pair of adjacent sensor pixel
110 are used for alternate cycles detection.As an example, two adjacent sensor pixel 110A and 110B are labelled in Fig. 3, point
It Bao Kuo not electrode 111A, 112A, 113A and electrode 111B, 112B, 113B.When work, such as first can be by sensor pixel
The extraction electrode 111A of 110A extracts glucose as anode as cathode, the extraction electrode 111B of sensor pixel 110B
The skin surface covered to sensor pixel 110A.The detecting electrode of sensor pixel 110A is (to electrode 111A, working electrode
112A, reference electrode 113A) extracted glucose can be detected.It is then possible to mentioning sensor pixel 110B
Take electrode 111B as cathode, the extraction electrode 111A of sensor pixel 110A extracts glucose to sensor as anode
The skin surface that pixel 110B is covered.The detecting electrode of sensor pixel 110B is (to electrode 111B, working electrode 112B, ginseng
Than electrode 113B) extracted glucose can be detected.Cathode in sensor pixel 110, to electrode, reference electrode
(i.e. electrode 111,113) can be Ag/AgCl electrode, cathode and can be same electrode to electrode.The above-mentioned course of work is
Alternating cyclical process, the electrode 111 of each sensor pixel 110 are used as cathode by alternate cycles, to electrode and anode, can be with
Ag/AgCl electrode is avoided to be consumed or inactivate.
Although the exemplary shape and layout of each electrode foregoinging illustrate in sensor pixel 110, however, it is understood that
The invention is not limited thereto.For example, each other shapes and layout can be used in electrode 111,112,113 and 114, if can or
Person is conducive to carry out extraction described above and detection process.Although in addition, being shown in Fig. 1 and Fig. 3 above multiple
Sensor pixel 110 is arranged as matrix array, but present invention is also not necessarily limited to this, but can be arranged to other array patterns.
The layout that Fig. 4 shows the sensor pixel array of the noninvasive dynamics monitoring device according to another embodiment of the application is shown
It is intended to.As shown in figure 4, multiple sensor pixels 110 may be arranged to honeycomb structure.Work in each sensor pixel 110
Polygonal shape, such as the regular hexagon of diagram can be had by making electrode 112, or other shapes for example square, rectangle,
Regular pentagon etc., or can also be arranged around for circle, other electrodes on the periphery of working electrode 112.Although Fig. 4 is shown
Three-electrode structure, but be also possible to four electrode structures etc..The advantage of the sensor array of this honeycombed arrangement is: phase
For matrix arrangement, each sensor pixel has more adjacent pixels.The array of the sensor pixel of honeycombed arrangement, wherein
Sensor pixel can at most have 6 adjacent sensor pixels, and the array of the sensor pixel of matrix arrangement, sensing therein
Device pixel at most only has 4 adjacent sensor pixels.Therefore, the sensor pixel array of honeycombed arrangement can have bigger several
Rate makes each of two adjacent sensor pixels cover at least one hair follicle, or each single hair follicle of covering, so as to
Alternate cycles detection described above is enough executed, the detection efficiency of sensor pixel array is improved.Certainly, sensor pixel array
100 also can have other array patterns, such as concentric circles etc..
Fig. 5 is according to the wearing structural schematic diagram of the noninvasive dynamics monitoring device of one embodiment of the application, and Fig. 6 is according to this
Apply for the wearing structural schematic diagram of the noninvasive dynamics monitoring device of another embodiment.As it can be seen in figures 5 and 6, noninvasive blood of the invention
Sugar detection device further includes data processing unit 200, can be connected to multisensor pixel array 100 by route 300.Though
It is Wireline that right Fig. 5, which shows route 300, but it is also possible to radiolink, such as multisensor pixel array 100
It detects signal and is wirelessly transmitted to data processing unit 200 through short-haul connections mode.It is carry-on that data processing unit 200 can be user
The portable electronic device being worn or carried by, such as be desirably integrated into the mobile phone of user.In the embodiment in fig 6, more sensings
Together with device pixel array 100 can integrate with data processing unit 200, the detection signal quilt of multisensor pixel array 100
It is supplied directly to data processing unit 200, the two can be worn on together on such as arm 400 of user.
Data processing unit 200 is used for the detection generated when detecting extracted glucose to each sensor pixel 110
Signal is handled, with the concentration of the extracted glucose of determination.Specifically, the detection signal that sensor pixel 110 generates,
Such as detection electric current, it is proportional to the concentration of glucose.May include in data processing unit 200 have memory, such as ROM,
EEPROM, flash memory etc. can store a calibration curve, which describes between concentration of glucose and detection electric current
Relationship is generally linear relationship.Therefore, data processing unit 200 can be based on the detection letter that each sensor pixel 110 provides
It number determines corresponding concentration of glucose, and then determines the intracorporal blood sugar concentration of people.
When multisensor pixel array 100 is covered on human skin, although ensuring at least one as previously mentioned
Sensor pixel 110 covers at least one hair follicle, but it is also possible that one or more sensors pixel 110 does not cover any hair
Capsule.As previously mentioned, the glucose extractability of hair follicle will be much higher than other approach, therefore with cover at least one hair follicle sensing
Device pixel 110 is compared, and does not cover the amplitude of the detection signal of the generation of sensor pixel 110 of any hair follicle nearly close to zero.
Based on the characteristic, data processing unit 200 can determine which sensor pixel 110 covers at least one according to detection signal
A hair follicle, which sensor pixel 110 do not cover any hair follicle.Cover the generation of sensor pixel 110 of at least one hair follicle
Detection signal is considered effective detection signal, is used to detection concentration of glucose, and does not cover any hair follicle
The detection signal that sensor pixel 110 generates is considered invalid detection signal, can be dropped, so as to mention
The accuracy of high detection.
After being determined which sensor pixel 110 does not cover any hair follicle, data processing unit 200 is configurable to
These sensor pixels 110 are labeled as inactive pixels, and the repetition below is extracted and do not use these nothings when detecting
Pixel is imitated, to improve detection efficiency and accuracy.
The present inventors have additionally discovered that although the glucose extractability of the hair follicle of different people is different, and because blood glucose
Horizontal variation, glucose extractability of the same hair follicle in different moments can be also varied, but mutually in the same time, phase
The glucose extractability of adjacent hair follicle is essentially identical.That is, the sensor pixel 110 of two hair follicles of covering detects
Concentration of glucose can be one hair follicle of covering the concentration of glucose that detects of sensor pixel 110 approximately twice as a left side
It is right.Using the characteristic, when at least one sensor pixel 110 covers single hair follicle, data processing unit 200 is configurable to
It identifies such sensor pixel 110, and based on it, determines the hair follicle number of each sensor pixel covering.
It is appreciated that glucose described above extracts and detection process can use 110 He of multisensor pixel array
Data processing unit 200 repeatedly carries out, to realize the lasting monitoring of blood sugar concentration.In some embodiments, at data
Reason unit 200 can will test result storage in memory, show measurement result by display such as liquid crystal display,
Or result will test by wired or wireless connection and be sent to other equipment, such as be sent to the information of hospital by internet
The data system of management system or patient doctor.When blood glucose value is more than certain level, various forms of polices can also be triggered
The number of notifying.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest scope of cause.
Claims (28)
1. a kind of noninvasive dynamics monitoring device, the array including multiple sensor pixels, each sensor pixel include:
Electrode is extracted, for permeating by reverse ion through user's skin extraction glucose；And
Detecting electrode, for detecting the concentration of extracted glucose by electrochemical method,
Wherein, the array configuration of the multiple sensor pixel is at least one sensing when being attached on user's skin surface
Device pixel covers at least one hair follicle of user's skin and glucose is extracted and detected by it.
2. noninvasive dynamics monitoring device according to claim 1 further includes for supporting the multiple sensor pixel
The substrate of array.
3. noninvasive dynamics monitoring device according to claim 2, wherein the substrate is flexible substrate.
4. noninvasive dynamics monitoring device according to claim 1, wherein the extraction electrode includes anode and cathode,
For reverse ion infiltration lane being formed in user's skin to extract glucose.
5. noninvasive dynamics monitoring device according to claim 4, wherein the detecting electrode includes reference electrode, work
Electrode and to electrode, the concentration of extracted glucose is detected by electrochemical reaction.
6. noninvasive dynamics monitoring device according to claim 5, wherein the cathode and it is described be same electricity to electrode
Pole.
7. noninvasive dynamics monitoring device according to claim 5, wherein the anode includes Ag, the cathode, the ginseng
It examines electrode and described Ag/AgCl is each included to electrode.
8. noninvasive dynamics monitoring device according to claim 1, wherein the extraction electrode of two adjacent sensor pixels point
Not Yong Zuo anode and cathode, in user's skin formed reverse ion infiltration lane to extract glucose.
9. noninvasive dynamics monitoring device according to claim 8, wherein the detecting electrode includes reference electrode, work
Electrode and to electrode, the concentration of extracted glucose is detected by electrochemical reaction.
10. noninvasive dynamics monitoring device according to claim 9, wherein the extraction electrode and it is described be same to electrode
One electrode.
11. noninvasive dynamics monitoring device according to claim 9, wherein the extraction electrode, the reference electrode and institute
It states and Ag/AgCl is each included to electrode.
12. the noninvasive dynamics monitoring device according to claim 5 or 9, wherein the working electrode includes:
Layer of precious metal；
Catalyst layer on the layer of precious metal is set；And
Glucose oxidase layer on the catalyst layer is set, and the glucose oxidase layer is catalyzed extracted glucose
Oxidation reaction to generate hydrogen peroxide, the decomposition of the catalyst layer catalyzing hydrogen peroxide is to generate kinetic current.
13. the noninvasive dynamics monitoring device according to claim 5 or 9, wherein the working electrode includes:
Graphene layer with noble metal nano particles；And
Glucose oxidase layer on the graphene layer is set, and the glucose oxidase layer is catalyzed extracted glucose
Oxidation reaction to generate hydrogen peroxide, the decomposition of the noble metal nano particles layer catalyzing hydrogen peroxide is to generate reaction electricity
Stream.
14. the noninvasive dynamics monitoring device according to claim 5 or 9, wherein the working electrode includes oxo transition metal
Compound layer.
15. noninvasive dynamics monitoring device according to claim 14, wherein the transition metal oxide layer includes transition
The compound of metal oxide.
16. noninvasive dynamics monitoring device according to claim 15, wherein the compound packet of the transition metal oxide
Include nickel oxide, tin oxide and indium oxide.
17. noninvasive dynamics monitoring device according to claim 14, wherein the transition metal oxide layer has porous
Structure.
18. noninvasive dynamics monitoring device according to claim 1, wherein the array configuration of the multiple sensor pixel
For when being attached on user's skin surface, the detecting electrode of at least one sensor pixel covers at least one of user's skin
Hair follicle.
19. the noninvasive dynamics monitoring device according to claim 5 or 9, wherein the array of the multiple sensor pixel is matched
It is set to when being attached on user's skin surface, the working electrode of the detecting electrode of at least one sensor pixel covers user's skin
At least one hair follicle of skin.
20. the noninvasive dynamics monitoring device according to claim 5 or 9, wherein in each sensor pixel, the work
The area for making electrode is greater than the area of other any electrodes.
21. noninvasive dynamics monitoring device according to claim 1, wherein the array configuration of the multiple sensor pixel
For wherein each sensor pixel area in 1mm2To 80mm2Between, preferably in 2mm2To 50mm2Between, more preferably exist
3mm2To 20mm2Between, more preferably in 4mm2To 9mm2Between.
22. noninvasive dynamics monitoring device according to claim 1, wherein the array configuration of the multiple sensor pixel
For matrix pattern, honeycomb pattern or concentric circles.
23. noninvasive dynamics monitoring device according to claim 1, wherein the array configuration of the multiple sensor pixel
Being includes at least four sensor pixel, preferably at least 16 sensor pixels, more preferably at least 36 sensor pixels,
More preferably at least 64 sensor pixels.
24. noninvasive dynamics monitoring device according to claim 1, further includes:
Data processing unit, the detection signal generated when for detecting the concentration of extracted glucose to each sensor pixel
It is handled, with the concentration of the extracted glucose of determination.
25. noninvasive dynamics monitoring device according to claim 24, wherein the data processing unit includes memory,
Storage is defined concentration of glucose and detects the calibration curve of the relationship between electric current, the data processing list in the memory
Member calculates detected concentration of glucose using the calibration curve.
26. noninvasive dynamics monitoring device according to claim 24, wherein the data processing unit is configured to from each
Determine that effective detection signal, the effective detection signal are to cover at least one in the detection signal that sensor pixel provides
The detection signal that the sensor pixel of hair follicle generates.
27. noninvasive dynamics monitoring device according to claim 26, wherein the data processing unit is additionally configured to select
The sensor pixel of effective detection signal is generated to repeat the extraction and detection of glucose.
28. noninvasive dynamics monitoring device according to claim 24, wherein the array configuration of the multiple sensor pixel
For when being attached on user's skin surface, at least one sensor pixel covers the single hair follicle of user's skin, the data
Processing unit is configured to the hair follicle that the detection signal that each sensor pixel provides determines each sensor pixel covering
Number.
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