CN110237190A - A Method for Improving the Treatment of Polycystic Ovarian Syndrome with Integrated Traditional Chinese and Western Medicine - Google Patents

Abstract

The present invention relates to a kind of improvement Stein-Leventhal syndrome therapy of combing traditional Chinese and Western medicine methods, the treatment method includes innerwear Chinese medicine preparation and injection Western medicine compound, the Chinese materia medica preparation is improved for patient's body basis, and the Western medicine compound is for promoting patient's body ovary ovulation function.The invention solves overcome prior art disadvantage, collaborative treatment of Chinese and western medicines, Chinese and western medical science combined treatment mode, Chinese materia medica preparation is mainly used for the conditioning of patient's body basis, and Western medicine compound is primarily to facilitate patient's body ovary ovulation function, complements each other, not only reduce drug side-effect, and quickly decorporation improves patient's constitution, reduces medicine band and carrys out side effect, has fabulous curative effect in the treatment of Stein-Leventhal syndrome.

Description

A Method for Improving the Treatment of Polycystic Ovarian Syndrome with Integrated Traditional Chinese and Western Medicine

technical field

The invention relates to the technical field of pharmaceutical treatment methods, in particular to a treatment method for improving polycystic ovary syndrome with integrated traditional Chinese and western medicine.

Background technique

The etiology of polycystic ovary syndrome is unknown so far, the pathogenesis is complicated, the condition is stubborn, the course of disease is long, the recurrence rate is high, and the clinical treatment is quite difficult.

Diane-35, a commonly used contraceptive pill for PCOS patients, cannot restore the female physiological-ovulatory menstrual cycle; compared with non-PCOS patients, the baseline risk of venous thromboembolic disease in PCOS patients increased by 1.5 times, and that of patients using Diane-35 increased by 3.7 Second, Diane-35 used in the treatment of adolescent PCOS can largely inhibit the growth of girls' height. Both spironolactone and metformin have no effect on regulating menstruation. For patients with oligomenorrhea or amenorrhea, long-term use of spironolactone is prone to endometrial hyperplasia or endometrial cancer. It has been reported that the application of metformin in the second trimester may increase perinatal fetal mortality, and some patients who take metformin at the same time may experience gastrointestinal reactions, such as diarrhea, nausea, vomiting, abdominal distension and anorexia. Drugs and surgical ovulation induction have limitations. Ovulation can only be produced during treatment and spontaneous ovulation cannot be restored, and it cannot be used for a long time. Clomiphene (CC), urinary gonadotropin (HMG), and human chorionic gonadotropin (HCG) can cause multiple births , Ovarian hyperstimulation syndrome (OHSS). Although ovarian wedge resection and laparoscopic ovarian drilling can avoid multiple pregnancy and have a low miscarriage rate, there are disadvantages such as conventional laparoscopic surgery risks, adhesions, and damage to normal ovarian tissue. In vitro fertilization-embryo transfer (IVF-ET) has the characteristics of large number of retrieved eggs, low fertilization rate and high incidence of OHSS.

Traditional Chinese medicine believes that the pathogenesis of polycystic ovary syndrome is kidney, liver and spleen dysfunction, phlegm turbidity, and stagnant blood stagnation, which mostly belong to the syndrome of deficiency in the root and excess in the superficiality. The core of TCM treatment of polycystic ovary syndrome is syndrome differentiation and treatment. The common syndrome types are spleen and kidney yang deficiency, phlegm and blood stasis, kidney deficiency and blood stasis, and kidney yin deficiency. The treatment methods focus on tonifying the kidney, promoting blood circulation to remove blood stasis, and dispelling dampness and resolving phlegm. A few of them use the method of soothing the liver and invigorating the spleen according to syndrome differentiation; However, it is often difficult to solve the amenorrhea and menstrual disorders caused by continuous anovulation, hirsutism and acne caused by hyperandrogen in clinical practice, so the treatment mode of "Chinese medicine combined with oral contraceptives" is often used clinically; Because it is difficult to achieve the effect of spontaneous ovulation, the treatment mode of "Chinese medicine combined with Western medicine to induce ovulation" is often used for those who have fertility requirements. Therefore, the combination of traditional Chinese and Western medicine is a more scientific and effective treatment method.

Contents of the invention

The technical problem to be solved by the present invention is to overcome the shortcomings of the prior art and provide a method for improving the treatment of polycystic ovary syndrome with integrated traditional Chinese and western medicine. The combination of traditional Chinese and western medicine is used for the basic conditioning of the patient's body, and the western medicine composition is mainly used for To promote the ovulation function of the patient's body.

In order to solve the above technical problems, the technical solution provided by the present invention is: a method for improving the treatment of polycystic ovary syndrome with integrated traditional Chinese and Western medicine, the treatment method includes oral administration of traditional Chinese medicine preparations and injections of western medicine compositions, and the traditional Chinese medicine preparations are used for the patient's body. For basic conditioning, the western medicine composition is used to promote the ovarian ovulation function of a patient's body.

Further, the traditional Chinese medicine preparation includes the following raw materials by weight: 3-5 parts of perilla seed, 4-6 parts of Cortex Phellodendri, 3-7 parts of Salvia miltiorrhiza, 10-14 parts of peach kernel, 3-5 parts of Scrophulariaceae, 4 parts of Dendrobium -6 parts, 5-9 parts of dogtail, 4-6 parts of rosette fern, 8-12 parts of Ligustrum lucidum, 4-6 parts of Alisma, 5-9 parts of berberine, 10-14 parts of plantain , 5-9 parts of knotweed, 10-14 parts of pearl grass.

Further, the preparation method of the Chinese medicine preparation comprises the following steps:

1) Take the washed raw materials of traditional Chinese medicine and mix them uniformly according to sufficient parts, and use ethanol aqueous solution to reflux for extraction twice, for the first time use 8 times the amount of 70% ethanol to reflux for 2 hours, filter, and for the second time use 6 times the amount of 70% ethanol Ethanol was refluxed for 1.5 hours, filtered; the refluxed extracts were combined and concentrated to obtain an alcohol extract;

2), decoct the medicinal residues extracted by reflux in step 1 twice, decoct for 2 hours with 12 times the amount of purified water for the first time, filter, and decoct for 1.5 hours with 8 times the amount of purified water for the second time, filter ; Combine the extracts, concentrate, and obtain a water extract;

3) Combine the above alcohol extract and water extract, add 90% ethanol aqueous solution by volume, let stand for precipitation, filter, concentrate the supernatant to obtain a clear ointment, and prepare a Chinese medicine preparation for oral administration.

Further, the western medicine composition includes physiological saline injection containing PCSK9 inhibitor.

Further, Alirocumab is selected as the PCSK9 inhibitor, and the injection dose of the physiological saline injection is determined according to the weight of the recipient, and is 1-8 mg/Kg.

Further, the traditional Chinese medicine preparation is taken orally within 10-30 minutes of injection of the western medicine composition. .

The present invention has the following advantages: the present invention solves the problem that the current conventional treatment of polycystic ovary syndrome can only be symptomatic treatment and the side effects caused by existing therapeutic drugs; while the combination of Chinese and Western medicine is the treatment method, and the traditional Chinese medicine preparation is mainly used for the basic conditioning of the patient's body The western medicine composition is mainly used to promote the ovarian ovulation function of the patient's body, complement each other, not only reduce the side effects of the medicine, but also quickly stimulate ovulation and improve the patient's physical fitness. In the present invention, through the rational proportioning of each Chinese medicine raw material and the interaction between each component, it has a good curative effect on patients with polycystic ovary syndrome, and its outstanding curative effect is that it can restore the patient's spontaneous ovulation menstrual cycle, reduce its High androgen and improvement of acne signs, high safety and small side effects on the human body, reducing risk; the western medicine composition of the present invention is treated with PCSK9 inhibitors, which will reduce low-density lipoprotein cholesterol, and lipids in the liver and ovary Droplet content decreased, testosterone decreased, ovarian shape improved, cystic follicles decreased, and atretic follicles decreased; ovarian ovulation function also improved, and egg quality improved. The integrated traditional Chinese and western medicine treatment method of the present invention, on the basis of promoting excretion of western medicine, quickly improves the patient's internal constitution, and then maintains the stability of the internal environment through traditional Chinese medicine preparations, reduces the side effects of the medicine, and has an excellent effect in the treatment of polycystic ovary syndrome. curative effect.

Detailed ways

The present invention will be further described in detail below in conjunction with the examples.

A treatment method for improving polycystic ovary syndrome with integrated traditional Chinese and Western medicine, said treatment method comprising oral administration of traditional Chinese medicine preparations and injections of western medicine compositions, said Chinese medicine preparations are used for the basic conditioning of the patient's body, and said western medicine compositions are used to promote the development of the patient's body's ovarian Ovulation function.

Example 1

The traditional Chinese medicine preparation includes the following raw materials by weight: 3 parts of perilla seed, 4 parts of Cortex Phellodendri, 3 parts of Salvia miltiorrhiza, 10 parts of peach kernel, 3 parts of Scrophulariaceae, 4 parts of dendrobium, 5 parts of dogtail cloth, 4 parts of rosette fern , 8 parts of Ligustrum lucidum, 4 parts of Alisma, 5 parts of Hu Huanglian, 10 parts of plantain, 5 parts of knotweed, and 10 parts of pearl grass.

The preparation method of described Chinese medicine preparation comprises the steps:

1) Take the washed raw materials of traditional Chinese medicine and mix them uniformly according to sufficient parts, and use ethanol aqueous solution to reflux for extraction twice, for the first time use 8 times the amount of 70% ethanol to reflux for 2 hours, filter, and for the second time use 6 times the amount of 70% ethanol Ethanol was refluxed for 1.5 hours, filtered; the refluxed extracts were combined and concentrated to obtain an alcohol extract;

2), decoct the medicinal residues extracted by reflux in step 1 twice, decoct for 2 hours with 12 times the amount of purified water for the first time, filter, and decoct for 1.5 hours with 8 times the amount of purified water for the second time, filter ; Combine the extracts, concentrate, and obtain a water extract;

3) Combine the above alcohol extract and water extract, add 90% ethanol aqueous solution by volume, let stand for precipitation, filter, concentrate the supernatant to obtain a clear ointment, and prepare a Chinese medicine preparation for oral administration.

The western medicine composition includes a physiological saline injection containing a PCSK9 inhibitor, and the PCSK9 inhibitor is selected from Alirocumab, and the injection dose of the physiological saline injection is determined according to the weight of the recipient, and is 1 mg/Kg.

The traditional Chinese medicine preparation is taken orally within 10 minutes after injection of the western medicine composition.

Example 2

The traditional Chinese medicine preparation includes the following raw materials by weight: 5 parts of perilla seed, 6 parts of Cortex Phellodendri, 7 parts of Salvia miltiorrhiza, 14 parts of peach kernel, 5 parts of Scrophulariaceae, 6 parts of dendrobium, 9 parts of dogtail, 6 parts of rosette fern 12 parts of Ligustrum lucidum, 6 parts of Alisma, 9 parts of Hu Huanglian, 14 parts of plantain, 9 parts of knotweed, and 14 parts of pearl grass.

The preparation method of described Chinese medicine preparation comprises the steps:

1) Take the washed raw materials of traditional Chinese medicine and mix them uniformly according to sufficient parts, and use ethanol aqueous solution to reflux for extraction twice, for the first time use 8 times the amount of 70% ethanol to reflux for 2 hours, filter, and for the second time use 6 times the amount of 70% ethanol Ethanol was refluxed for 1.5 hours, filtered; the refluxed extracts were combined and concentrated to obtain an alcohol extract;

2), decoct the medicinal residues extracted by reflux in step 1 twice, decoct for 2 hours with 12 times the amount of purified water for the first time, filter, and decoct for 1.5 hours with 8 times the amount of purified water for the second time, filter ; Combine the extracts, concentrate, and obtain a water extract;

3) Combine the above alcohol extract and water extract, add 90% ethanol aqueous solution by volume, let stand for precipitation, filter, concentrate the supernatant to obtain a clear ointment, and prepare a Chinese medicine preparation for oral administration.

The western medicine composition includes a physiological saline injection containing a PCSK9 inhibitor, and the PCSK9 inhibitor is selected from Alirocumab, and the injection dose of the physiological saline injection is determined according to the weight of the recipient, and is 8 mg/Kg.

The traditional Chinese medicine preparation is taken orally within 30 minutes after injection of the western medicine composition.

Example 3

The traditional Chinese medicine preparation includes the following raw materials by weight: 4 parts of perilla seed, 5 parts of Cortex Phellodendri, 5 parts of Salvia miltiorrhiza, 12 parts of peach kernel, 4 parts of Scrophulariaceae, 5 parts of dendrobium, 7 parts of dogtail cloth, 5 parts of rosette fern 10 parts of Ligustrum lucidum, 5 parts of Alisma, 7 parts of Hu Huanglian, 12 parts of plantain, 7 parts of Polygonum cuspidatum, and 12 parts of pearl grass.

The preparation method of described Chinese medicine preparation comprises the steps:

1) Take the washed raw materials of traditional Chinese medicine and mix them uniformly according to sufficient parts, and use ethanol aqueous solution to reflux for extraction twice, for the first time use 8 times the amount of 70% ethanol to reflux for 2 hours, filter, and for the second time use 6 times the amount of 70% ethanol Ethanol was refluxed for 1.5 hours, filtered; the refluxed extracts were combined and concentrated to obtain an alcohol extract;

2), decoct the medicinal residues extracted by reflux in step 1 twice, decoct for 2 hours with 12 times the amount of purified water for the first time, filter, and decoct for 1.5 hours with 8 times the amount of purified water for the second time, filter ; Combine the extracts, concentrate, and obtain a water extract;

3) Combine the above alcohol extract and water extract, add 90% ethanol aqueous solution by volume, let stand for precipitation, filter, concentrate the supernatant to obtain a clear ointment, and prepare a Chinese medicine preparation for oral administration.

The western medicine composition includes a physiological saline injection containing a PCSK9 inhibitor, and the PCSK9 inhibitor is selected from Alirocumab, and the injection dose of the physiological saline injection is determined according to the weight of the recipient, and is 4 mg/Kg.

The traditional Chinese medicine preparation is taken orally within 20 minutes after injection of the western medicine composition.

Fructus Perillae: pungent in nature and flavor, warm, non-toxic, functions mainly for lowering qi, reducing phlegm, moistening the lungs, and widening the intestines. Cure cough, phlegm and asthma, qi stagnation and constipation;

Phellodendron Phellodendri: bitter in nature and flavor, cold, returns to kidney, bladder, large intestine meridian; function of clearing away heat and dampness, purging fire and detoxifying, hemostasis;

Radix Salviae Miltiorrhizae: bitter in nature and flavor, be slightly cold, return heart, Liver Channel; Function dispelling blood stasis to relieve pain, promoting blood circulation to stimulate menstrual flow, nourishing the heart and relieving restlessness, cooling blood and eliminating carbuncle;

Peach kernel: bitter in nature and flavor, sweet, flat, heart-guiding, liver, and large intestine meridian; function of promoting blood circulation and removing blood stasis, moistening intestines and laxative;

Radix Scrophulariae: sweet in nature and flavor, bitter, salty, slightly cold, returns to lung, stomach, kidney meridians; function of clearing heat and cooling blood, nourishing yin, purging fire and detoxifying;

Dendrobium: sweet in nature and flavor, slightly cold, returns to the stomach and kidney meridians; function nourishes yin and clears away heat, nourishes the stomach and promotes body fluid;

Cloth dog tail: light taste, cool. Functions and indications Clearing away heat and resolving phlegm, cooling blood to stop bleeding, killing parasites, used for colds, coughs, malaria, blood filariasis, malnutrition in children, vomiting blood, hemoptysis, hematuria;

Rosaceae spinosa: mild in taste, astringent, cool in nature, functions mainly for clearing heat and promoting dampness; phlegm and cough; detoxification and swelling, controlling diarrhea; dysentery; cough due to lung heat; scrofula; mumps; carbuncle furuncle; bone fracture; venomous snake bite hurt;

Ligustrum lucidum: sweet in nature and flavor, bitter, cool, returns to the liver and kidney meridians; function nourishes the liver and kidney, black hair improves eyesight;

Alisma: sweet and cold in nature and flavor, returns to the kidney and bladder meridian; functions in diuresis and dampness expelling, expels heat;

Coptis chinensis: bitter in nature and flavor, cold, returns to liver, stomach, large intestine meridian; function of clearing away damp-heat, reducing asthenia-heat, removing malnutrition-heat;

Plantain: sweet and cold in nature and flavor, returns to the kidney, liver, and lung meridians; functions diuresis, clearing away heat, improving eyesight, and eliminating phlegm;

Polygonum cuspidatum: slightly bitter in nature and flavor, slightly cold, returns to the lung, liver, and gallbladder meridian; function of clearing heat and detoxifying, promoting dampness and reducing jaundice, dissipating blood stasis and relieving pain, resolving phlegm and relieving cough;

Pearl grass: nature and flavor are bitter, sweet, cool, return lung, liver meridian; function heat-clearing and toxic substances removing, promoting dampness to reduce jaundice, improving eyesight, eliminating stagnation.

Through experimental comparison, the treatment mode in the present invention can have excellent curative effect on the treatment of polycystic ovary syndrome.

Although the present invention has been described in detail with general descriptions and specific embodiments above, it is obvious to those skilled in the art that some modifications or improvements can be made on the basis of the present invention. Therefore, the modifications or improvements made on the basis of not departing from the spirit of the present invention all belong to the protection scope of the present invention.

Claims (6)

1. a kind of improvement Stein-Leventhal syndrome therapy of combing traditional Chinese and Western medicine method, which is characterized in that the treatment method includes interior Take traditional Chinese medicine preparation and injection Western medicine compound, and the Chinese materia medica preparation is used for the conditioning of patient's body basis, the Western medicine compound In promotion patient's body ovary ovulation function.

2. a kind of improvement Stein-Leventhal syndrome therapy of combing traditional Chinese and Western medicine method according to claim 1, which is characterized in that The Chinese materia medica preparation includes the raw material of following composition by weight: 3-5 parts of Perilla frutescens, 4-6 parts of Cortex Phellodendri, 3-7 parts of Radix Salviae Miltiorrhizae, peach kernel 10-14 Part, 3-5 parts of radix scrophulariae, 4-6 parts of dendrobium nobile, 5-9 parts of macrostachys uraria herb, 4-6 parts of handle lotus throne fern of thorn, 8-12 parts of the fruit of glossy privet, 4-6 parts of rhizoma alismatis, Hu 5-9 parts of the coptis, 10-14 parts of Asiatic plantain, 5-9 parts of polygonum cuspidate, 10-14 parts of Sagina subulata.

3. a kind of improvement Stein-Leventhal syndrome therapy of combing traditional Chinese and Western medicine method according to claim 1, which is characterized in that The preparation method of the Chinese materia medica preparation includes the following steps:

1) clean Chinese medicine material, is taken uniformly to mix according to enough numbers, twice using ethanol water refluxing extraction, for the first time With 8 times of 70% alcohol refluxs of amount 2 hours, filtering, second with 6 times of 70% alcohol refluxs of amount 1.5 hours, filter；Merge reflux Extracting solution, concentration, obtains alcohol extract；

2) it, by the dregs of a decoction of refluxing extraction in step 1, decocts and extracts twice, decoct 2 hours, mistake with 12 times of amount purified waters for the first time Filter decocts 1.5 hours, filtering with 8 times of amount purified waters for the second time；Combined extract, concentration, obtains aqueous extract；

3), above-mentioned alcohol extract and aqueous extract are merged, the ethanol water that percent by volume is calculated as 90% is added, it is heavy to stand It forms sediment, filtering, concentrated supernatant obtains clear cream, and the Chinese materia medica preparation taken after mixing it with water is made.

4. a kind of improvement Stein-Leventhal syndrome therapy of combing traditional Chinese and Western medicine method according to claim 1, which is characterized in that The Western medicine compound includes the normal saline solution of the inhibitor containing PCSK9.

5. a kind of improvement Stein-Leventhal syndrome therapy of combing traditional Chinese and Western medicine method according to claim 1, which is characterized in that The PCSK9 inhibitor selects Alirocumab, and the injection dosage of the normal saline solution is according to depending on by body weight 1-8mg/Kg。

6. a kind of improvement Stein-Leventhal syndrome therapy of combing traditional Chinese and Western medicine method according to claim 1, it is characterised in that: The Western medicine compound injects innerwear Chinese medicine preparation in 10-30 minutes.