CN110227402A - A kind of device preparing D-galactosamine hydrochloride - Google Patents
A kind of device preparing D-galactosamine hydrochloride Download PDFInfo
- Publication number
- CN110227402A CN110227402A CN201910516060.1A CN201910516060A CN110227402A CN 110227402 A CN110227402 A CN 110227402A CN 201910516060 A CN201910516060 A CN 201910516060A CN 110227402 A CN110227402 A CN 110227402A
- Authority
- CN
- China
- Prior art keywords
- shaft
- agitating
- agitating paddle
- level
- mixed solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XZXLYGAUEAPJET-UHFFFAOYSA-N 5-amino-3h-1-benzofuran-2-one Chemical compound NC1=CC=C2OC(=O)CC2=C1 XZXLYGAUEAPJET-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 239000011259 mixed solution Substances 0.000 claims abstract description 35
- 238000006243 chemical reaction Methods 0.000 claims abstract description 20
- 230000001154 acute effect Effects 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 238000005276 aerator Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 10
- 238000010586 diagram Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- QARVLSVVCXYDNA-UHFFFAOYSA-N bromobenzene Chemical compound BrC1=CC=CC=C1 QARVLSVVCXYDNA-UHFFFAOYSA-N 0.000 description 2
- 231100000753 hepatic injury Toxicity 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- QKPLRMLTKYXDST-BMZZJELJSA-N D-(+)-Galactosamine hydrochloride Chemical compound Cl.N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O QKPLRMLTKYXDST-BMZZJELJSA-N 0.000 description 1
- 206010019799 Hepatitis viral Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002687 intercalation Effects 0.000 description 1
- 238000009830 intercalation Methods 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000029052 metamorphosis Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical compound NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0066—Stirrers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The invention discloses a kind of devices of D-galactosamine hydrochloride, are related to chemical equipment technical field.The device of the D-galactosamine hydrochloride, comprising: reaction kettle, the interior inner cavity being equipped with for accommodating mixed solution；Agitating shaft is controlled by motor, further includes: second level shaft is set on the agitating shaft, and the angle between the agitating shaft is acute angle or obtuse angle, and the agitating paddle is rotationally connected with the end of the second level shaft；Electric motor is set in the second level shaft, and the agitating paddle is driven to rotate, and when the agitating shaft drives second level shaft rotation, the agitating paddle is not only whole to be rotated with the agitating shaft, but also is controlled by the electric motor rotation.Acute angle and obtuse angle are presented between second level shaft and agitating shaft, i.e. non-parallel state, so that agitating paddle is in heeling condition, not only rotation is also rotated with second level shaft around agitating shaft agitating paddle, therefore the stirring range of agitating paddle is increased, prevents mixed solution from moving synchronously with agitating paddle.
Description
Technical field
The present invention relates to chemical equipment technical fields, more particularly to a kind of device of D-galactosamine hydrochloride.
Background technique
The device (the device LN of D-GD- galactosamine hydrochloride) of D-galactosamine hydrochloride can make kinds of experiments animal inducing
Send out hepatic injury.There are many identical spies with the performance of clinically virus hepatitis for the liver function and metamorphosis that animal occurs after poisoning
Point.Liver injury model is made with it, it is more superior than with carbon tetrachloride, ethyl alcohol, bromobenzene, second sulphamide etc..Screening anti-liver both at home and abroad
It is had been widely used when damage medicine.
During the preparation process due to D-galactosamine hydrochloride, the reaction solution viscosity for needing to use is higher, so that reaction
Preceding being stirred is not easy to be sufficiently mixed.
In the prior art, place is usually stirred as reaction solution by reaction kettle.Reaction kettle generally includes
Agitating shaft in intercalation reaction kettle, agitating shaft end are equipped with agitating paddle.The wherein center overlapping of axles of agitating shaft and reaction kettle.
But reaction kettle in the prior art by agitating shaft drive agitating paddle be stirred solution when, mixed solution by
Thrust ramps up rotation, so that gradually tending to move synchronously between mixed solution and agitating paddle.When having in mostly in mixed solution
When solution needs to mix, a variety of solution are synchronous to be flowed with agitating paddle, then the occurrence probability of the mutual impingement mix of different solutions becomes
Small, the reaction solution mixing caused is not enough, and influences the quality of finally obtained D-galactosamine hydrochloride.
Summary of the invention
The technical problem to be solved by the present invention is to the shortcomings that overcoming the prior art, provide a kind of D-galactosamine hydrochloric acid
The device of salt keeps the stirring of mixed solution more abundant.
In order to solve the above technical problems, the present invention provides a kind of device of D-galactosamine hydrochloride, comprising:
Reaction kettle, the interior inner cavity being equipped with for accommodating mixed solution；
Agitating shaft is controlled by motor, and the agitating shaft is inserted under the liquid level of mixed solution described in the inner cavity, and end is set
There is agitating paddle；
Further include:
Second level shaft is set on the agitating shaft, and the angle between the agitating shaft is acute angle or obtuse angle, and the agitating paddle turns
The dynamic end for being connected to the second level shaft；
Electric motor is set in the second level shaft, and the agitating paddle is driven to rotate, when the agitating shaft drives the second level to turn
When axis rotates, the agitating paddle is not only whole to be rotated with the agitating shaft, but also is controlled by the electric motor rotation.
The second level shaft is inserted into the liquid level, to increase the contact area of the second level shaft and the mixed solution,
When the second level shaft is controlled by motor rotation, the second level is pushed to turn the axial mixed solution movement.
The spatial form that the agitating paddle rotation is inswept is vertical with the second level shaft.
The agitating paddle is equipped at least one protrusion along the direction far from the second level shaft, makes the agitating paddle along separate
The surface irregularity in the direction of the second level shaft.
The agitating paddle end is equipped with expanding end, and the expanding end is protruded to outside the agitating paddle, to hinder the mixing
Solution is bonded the paddle length direction along the agitating paddle direction and moves.
The agitating paddle end is equipped with aerator, and the aerator includes:
Solarization air cap, set on the end of the agitating paddle and/or the agitating paddle；
The pump housing, Xiang Suoshu solarization air cap gas supply, to maintain the air pressure at the solarization air cap hydraulic not less than the mixed solution, from
And persistently inflated into the mixed solution, form bubble.
Further include:
Supporting table is set to above the reaction kettle, for installing the motor；
Relief hole is set in the supporting table, and for passing through for the agitating shaft, and the agitating shaft is controlled by the motor phase
The relief hole is rotated；
Cylinder is supported, bottom end is detachably connected on the reaction kettle top, and output end is supported in below the supporting table, and is driven
The supporting table does intermittent back and forth movement along the vertical direction.
There are certain intervals between the relief hole and the agitating shaft, to reduce the agitating shaft relative to the support
Resistance when platform slides along the vertical direction.
The beneficial effects of the present invention are:
(1) acute angle and obtuse angle, i.e., non-parallel state are presented between second level shaft and agitating shaft, so that agitating paddle is in skewed
State, not only rotation is also rotated with second level shaft around agitating shaft agitating paddle, therefore increases the stirring range of agitating paddle, prevents from mixing
Solution is moved synchronously with agitating paddle.；
(2) expanding end continues the inflation into mixed solution and forms multiple bubbles in mixed solution, and bubble is during rotation not
Disconnected rise simultaneously is evenly distributed in mixed solution, and when bubbles burst can accelerate the mixing of surrounding mixed solution.
Detailed description of the invention
Fig. 1 is schematic diagram of internal structure of the invention；
Fig. 2 is to indicate between second level shaft and agitating shaft the schematic diagram of situation in obtuse angle；
Fig. 3 is to indicate agitating paddle along far from the rough schematic diagram of second level rotor shaft direction.
Wherein: 1, reaction kettle；11, inner cavity；12, liquid level；2, motor；3, agitating shaft；31, second level shaft；32, agitating paddle；
33, expanding end；4, supporting table；41, cylinder is supported.
Specific embodiment
Wherein identical components are presented with like reference characters.It should be noted that word used in the following description
Language "front", "rear", "left", "right", "up" and "down" refer to the direction in attached drawing, word " bottom surface " and " top surface ", "inner" and
"outside" refers respectively to the direction towards or away from geometric center of specific component.
Embodiment 1:
A kind of device of D-galactosamine hydrochloride provided in this embodiment, structure are as shown in the figure.
The device of the D-galactosamine hydrochloride, comprising:
Reaction kettle 1, the interior inner cavity 11 being equipped with for accommodating mixed solution；
Agitating shaft 3 is controlled by motor 2, and agitating shaft 3 is inserted into inner cavity 11 under the liquid level 12 of mixed solution, and end is equipped with and stirs
Mix paddle 32；
Further include:
Second level shaft 31 is set on agitating shaft 3, and the angle between agitating shaft 3 is acute angle or obtuse angle, and agitating paddle 32 is rotatablely connected
In the end of second level shaft 31；
Electric motor is set in second level shaft 31, and agitating paddle 32 is driven to rotate, when agitating shaft 3 drives second level shaft 31 to rotate,
Agitating paddle 32 is not only whole to be rotated with agitating shaft 3, but also is controlled by electric motor rotation.
Second level shaft 31 is inserted into liquid level 12, to increase the contact area of second level shaft 31 Yu mixed solution, when second level shaft
31 be controlled by motor 2 rotate when, push second level shaft 31 around mixed solution movement.
The spatial form that 32 rotation of agitating paddle is inswept is vertical with second level shaft 31.
Agitating paddle 32 is equipped at least one protrusion along the direction far from second level shaft 31, turns agitating paddle 32 along far from second level
The surface irregularity in the direction of axis 31.
32 end of agitating paddle is equipped with expanding end 33, and expanding end 33 is protruded to outside agitating paddle 32, to hinder mixed solution edge to stir
It is mobile to mix 32 direction of paddle fitting 32 length direction of agitating paddle.
32 end of agitating paddle is equipped with aerator, and aerator includes:
Solarization air cap, set on the end of agitating paddle 32 and/or agitating paddle 32；
The pump housing is supplied to solarization air cap, to maintain the air pressure at solarization air cap hydraulic not less than mixed solution, thus to mixed solution
In persistently inflate, formed bubble.
Further include:
Supporting table 4 is set to 1 top of reaction kettle, for installing motor 2；
Relief hole is set in supporting table 4, and for passing through for agitating shaft 3, and agitating shaft 3 is controlled by motor 2 and turns relative to relief hole
It is dynamic；
Cylinder ' ' 41 is supported, bottom end is detachably connected on 1 top of reaction kettle, and output end is supported in 4 lower section of supporting table, and drives branch
Support platform 4 does intermittent back and forth movement along the vertical direction.
There are certain interval between relief hole and agitating shaft 3, to reduce agitating shaft 3 relative to supporting table 4 along the vertical direction
Resistance when sliding.
Acute angle and obtuse angle are presented between second level shaft 31 and agitating shaft 3, i.e., non-parallel state is inclined so that agitating paddle 32 is in
Ramp-like state, not only rotation is also rotated with second level shaft 31 around agitating shaft 3 agitating paddle 32, therefore increases the stirring model of agitating paddle 32
It encloses, prevents mixed solution from moving synchronously with agitating paddle 32.；
Expanding end 33 continues the inflation into mixed solution and forms multiple bubbles in mixed solution, and bubble is continuous during rotation
Rise and be evenly distributed in mixed solution, when bubbles burst can accelerate the mixing of surrounding mixed solution.
In addition to the implementation, the present invention can also have other embodiments；It is all to use equivalent substitution or equivalent transformation shape
At technical solution, fall within the scope of protection required by the present invention.
Claims (8)
1. a kind of device of D-galactosamine hydrochloride, comprising:
Reaction kettle (1), the interior inner cavity (11) being equipped with for accommodating mixed solution；
Agitating shaft (3) is controlled by motor (2), and the agitating shaft (3) is inserted into the liquid level of mixed solution described in the inner cavity (11)
(12) under, end is equipped with agitating paddle (32)；
It is characterized by also including:
Second level shaft (31) is set on the agitating shaft (3), and the angle between the agitating shaft (3) is acute angle or obtuse angle, institute
State the end that agitating paddle (32) is rotationally connected with the second level shaft (31)；
Electric motor is set in the second level shaft (31), drives the agitating paddle (32) to rotate, when the agitating shaft (3) band
When moving the second level shaft (31) rotation, the agitating paddle (32) is not only whole to be rotated with the agitating shaft (3), but also controlled
In the electric motor rotation.
2. the device of D-galactosamine hydrochloride according to claim 1, it is characterised in that: the second level shaft (31) is inserted
Enter the liquid level (12), to increase the contact area of second level shaft (31) and the mixed solution, when the second level shaft
(31) when being controlled by motor (2) rotation, the mixed solution movement around the second level shaft (31) is pushed.
3. the device of D-galactosamine hydrochloride according to claim 2, it is characterised in that: agitating paddle (32) rotation
Inswept spatial form is vertical with second level shaft (31).
4. the device of D-galactosamine hydrochloride according to claim 3, it is characterised in that: the agitating paddle (32) is along remote
Direction from the second level shaft (31) is equipped at least one protrusion, makes the agitating paddle (32) along far from the second level shaft
(31) surface irregularity in direction.
5. the device of D-galactosamine hydrochloride according to claim 3, it is characterised in that: agitating paddle (32) end
Equipped with expanding end (33), expanding end (33) the Xiang Suoshu agitating paddle (32) is protruded outside, to hinder the mixed solution described in
It is mobile that agitating paddle (32) direction is bonded agitating paddle (32) length direction.
6. the device of D-galactosamine hydrochloride according to claim 1, it is characterised in that: agitating paddle (32) end
Equipped with aerator, the aerator includes:
Solarization air cap is set to the end of the agitating paddle (32) and/or the agitating paddle (32)；
The pump housing, Xiang Suoshu solarization air cap gas supply, to maintain the air pressure at the solarization air cap hydraulic not less than the mixed solution, from
And persistently inflated into the mixed solution, form bubble.
7. the device of D-galactosamine hydrochloride according to claim 1, it is characterised in that: further include:
Supporting table (4) is set to above the reaction kettle (1), for installing the motor (2)；
Relief hole is set on the supporting table (4), and for passing through for the agitating shaft (3), and the agitating shaft (3) is controlled by
The motor (2) rotates relative to the relief hole；
It supports cylinder (41), bottom end is detachably connected on the reaction kettle (1) top, and output end is supported in the supporting table (4)
Lower section, and the supporting table (4) is driven to do intermittent back and forth movement along the vertical direction.
8. the device of D-galactosamine hydrochloride according to claim 7, it is characterised in that: the relief hole is stirred with described
It mixes between axis (3) that there are certain intervals, is slided along the vertical direction with reducing the agitating shaft (3) relative to the supporting table (4)
When resistance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910516060.1A CN110227402A (en) | 2019-06-14 | 2019-06-14 | A kind of device preparing D-galactosamine hydrochloride |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910516060.1A CN110227402A (en) | 2019-06-14 | 2019-06-14 | A kind of device preparing D-galactosamine hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110227402A true CN110227402A (en) | 2019-09-13 |
Family
ID=67859367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910516060.1A Pending CN110227402A (en) | 2019-06-14 | 2019-06-14 | A kind of device preparing D-galactosamine hydrochloride |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110227402A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115445548A (en) * | 2022-08-25 | 2022-12-09 | 浙江亿普新材料科技有限公司 | Equipment and method for producing vinylene carbonate by external circulation method |
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| US20050174883A1 (en) * | 2002-04-17 | 2005-08-11 | Enersave Fluid Mixers Inc. | Mixing apparatus |
| CN204699613U (en) * | 2015-03-16 | 2015-10-14 | 南京林恒机械制造有限公司 | A kind of oil-water mixer |
| CN206381996U (en) * | 2016-12-29 | 2017-08-08 | 天津药物研究院药业有限责任公司 | A hydrogenation reactor |
| CN206392057U (en) * | 2016-12-29 | 2017-08-11 | 天津药物研究院药业有限责任公司 | a reaction kettle |
| CN108404743A (en) * | 2018-04-02 | 2018-08-17 | 中山市元亨家居用品有限公司 | Emulsion paint agitating unit |
-
2019
- 2019-06-14 CN CN201910516060.1A patent/CN110227402A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050174883A1 (en) * | 2002-04-17 | 2005-08-11 | Enersave Fluid Mixers Inc. | Mixing apparatus |
| CN204699613U (en) * | 2015-03-16 | 2015-10-14 | 南京林恒机械制造有限公司 | A kind of oil-water mixer |
| CN206381996U (en) * | 2016-12-29 | 2017-08-08 | 天津药物研究院药业有限责任公司 | A hydrogenation reactor |
| CN206392057U (en) * | 2016-12-29 | 2017-08-11 | 天津药物研究院药业有限责任公司 | a reaction kettle |
| CN108404743A (en) * | 2018-04-02 | 2018-08-17 | 中山市元亨家居用品有限公司 | Emulsion paint agitating unit |
Non-Patent Citations (1)
| Title |
|---|
| 陈志平等: "《搅拌与混合设备设计选用手册》", 31 May 2004 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115445548A (en) * | 2022-08-25 | 2022-12-09 | 浙江亿普新材料科技有限公司 | Equipment and method for producing vinylene carbonate by external circulation method |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190913 |
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| RJ01 | Rejection of invention patent application after publication |