CN110179897A - A kind of formula and preparation method thereof of stilbene rattan soup that treating knee osteoarthritis - Google Patents

A kind of formula and preparation method thereof of stilbene rattan soup that treating knee osteoarthritis Download PDF

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Publication number
CN110179897A
CN110179897A CN201910608083.5A CN201910608083A CN110179897A CN 110179897 A CN110179897 A CN 110179897A CN 201910608083 A CN201910608083 A CN 201910608083A CN 110179897 A CN110179897 A CN 110179897A
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soup
rattan
stilbene
formula
pack
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Inventor
尤君怡
梁国强
沈晓峰
马奇翰
龚正丰
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Suzhou Hospital of Traditional Chinese Medicine
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Suzhou Hospital of Traditional Chinese Medicine
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486Millettia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention discloses a kind of formulas and preparation method thereof of stilbene rattan soup for treating knee osteoarthritis, more particularly to pharmaceutical technology field, including raw Radix Astragali 50-70g, Sargent gloryvine 10-20g, Radix Angelicae Sinensis 5-15g, caulis lonicerae 10-20g, Pollen Typhae 6-14g, radix cyathulae 6-14g and licorice 4-8g.The present invention is arranged in pairs or groups by rational formula, raw Radix Astragali consolidates table, torr sore and Li Shui, it being capable of tonifying middle-Jiao and Qi, Sargent gloryvine promoting blood circulation and stopping pain and dispelling wind and eliminating dampness, Chinese angelica blood supplementing promoting blood circulation, caulis lonicerae detumescence, promote bone tissue reparation, Pollen Typhae hemostasia and dissipation blood stasis, radix cyathulae stasis-dispelling and pain-killing, licorice invigorating middle warmer and replenishing QI, coordinating the drug actions of a prescription, all medicine cooperations, which are adjusted, to fill blood, dissolving stasis leads to numbness, there is special effect to treatment knee osteoarthritis, in addition lemon tablet can improve blood circulation, keep bone, tissue and cartilage health, accelerate rehabilitation, dried peppermint leaf and honey is added, make soup fragrant odour, it is in good taste, improve the shelf-life of medicine soup.

Description

A kind of formula and preparation method thereof of stilbene rattan soup that treating knee osteoarthritis
Technical field
The present invention relates to pharmaceutical technology fields, it is more particularly related to a kind of stilbene rattan for treating knee osteoarthritis Formula of soup and preparation method thereof.
Background technique
Osteoarthritis is the pathological change based on cartilage degeneration, and clinic is with arthralgia, swelling and limitation of activity For the chronic osteoarthropathy of cardinal symptom.Multiple action of the pathogenesis by factors such as age factor, inherent cause, outside stimulus Cause the metabolism of synovial membrane, cartilage and bone to change, and then generates inflammation.Osteoarthritis belongs to " heumatism " scope.Think its morbidity not Outer affection of exogenous wind-cold damp evil, internal injury is qi-blood disharmony or have traumatic injury in kidney deficiency and liver, makes QI-blood circulation unsmooth, channels resistance Stagnant obstructed, then both liver and kidney deficiency, muscle cartilage wither disease long, dysfunction.The treatment of the illness, predominantly Chinese and western drugs treatment and non-medicine Object treatment, wherein non-drug therapy is Patients ' Healthy Education, self training, range of motion training, exercise for power, walk help tool Use, baker-kneed wedge insole, occupational therapy and joint protection, the auxiliary equipment of daily life etc.;Drug therapy includes: Sodium Hyaluronate intraarticular injection takes orally Glucosamine, oral or external application non-steroidal antalgic anti-inflammatory agent.
The patent of invention of 105381272 A of patent application publication CN discloses a kind of Chinese medicinal decoction for treating osteoarthritis Agent and preparation method thereof, including 17-35 parts of radix achyranthis bidentatae, 12-29 parts of Radix Astragali, 8-16 parts of Canton love-pea vine, 11-24 parts of Chinese Drug Gualouzi, meat desert It is 10-18 parts of Rong, 5-12 parts of FRUCTUS TERMINALIAE IMMATURUS, 15-28 parts of picria fel tarrae, 7-16 parts of Herba Lycopodii, 3-9 parts of callicarpa kwangtungensis Chun, 5-15 parts of Rhizoma Gastrodiae, bitter 4-16 parts of Chinese violet, 5-21 parts of Fructus Aurantii, foretell mustard 9-23 parts, 10-19 parts of Rhizoma Belamcandae, 12-28 parts of Cortex Eucommiae.Chinese medicine composition of the invention It dispels numbness effect with tonifying kidney and benefiting sperm, qi-blood tonifying, activating microcirculation and removing stasis medicinal, dredging collateral strengthening tendons, dispelling wind and eliminating dampness, analgesic, Different types of etiopathogenises is caused Osteoarthritis have significant therapeutic effect;Selected materials of the present invention are all traditional Chinese medicine material, and medicine source is easy to get, and curative effect is aobvious It writes, it is without any side effects.
But a kind of traditional Chinese herbal decoction and preparation method thereof for treating osteoarthritis provided in above-mentioned technical proposal, in reality With when, medicinal ingredient is complicated, and reaction is easy to happen after mixing, takes for a long time and is easy to human body generation side effect.
Summary of the invention
In order to overcome the drawbacks described above of the prior art, the embodiment of the present invention provides a kind of stilbene rattan for treating knee osteoarthritis Formula of soup and preparation method thereof is arranged in pairs or groups by formula, and raw Radix Astragali has effects that solid table, torr sore and sharp water, being capable of bowl spares benefit Gas, Sargent gloryvine have effects that promoting blood circulation and stopping pain and dispelling wind and eliminating dampness, and Radix Angelicae Sinensis has effects that replenishing and activating blood, and caulis lonicerae has the function of detumescence The effect of effect, promotion bone tissue reparation, Pollen Typhae has effects that hemostasia and dissipation blood stasis, and radix cyathulae has effects that stasis-dispelling and pain-killing, raw Radix Glycyrrhizae has effects that invigorating middle warmer and replenishing QI and coordinating the drug actions of a prescription, and all medicine cooperations, which are adjusted, to fill blood, and dissolving stasis leads to numbness, has to treatment knee osteoarthritis Special effect, in addition lemon tablet can improve blood circulation, promote wound healing, keep bone, tissue and cartilage health, prevent sclerotin It is loose, inhibit internal inflammation, accelerate rehabilitation, dried peppermint leaf and honey is added, makes soup fragrant odour, it is in good taste, moreover it is possible to improve medicine The shelf-life of soup, to solve the problems, such as proposed in background technique.
To achieve the above object, the invention provides the following technical scheme: a kind of stilbene rattan soup for treating knee osteoarthritis is matched Side, wherein used major ingredient includes: raw Radix Astragali 50-70g, Sargent gloryvine 10-20g, Radix Angelicae Sinensis 5-15g, caulis lonicerae 10- by weight 20g, Pollen Typhae 6-14g, radix cyathulae 6-14g and licorice 4-8g.
Preferably, the major ingredient includes: raw Radix Astragali 58-62g, Sargent gloryvine 13-17g, Radix Angelicae Sinensis 8-12g, caulis lonicerae by weight 13-17g, Pollen Typhae 8-12g, radix cyathulae 8-12g and licorice 5-7g.
It preferably, further include blender in the formula, the blender is made of honey, lemon tablet and dried peppermint leaf.
Preferably, the usage amount of the blender is respectively set are as follows: 2-5 spoons of honey, lemon tablet 2-3 piece and dried peppermint leaf 3-4 Piece.
A kind of preparation method of the formula of stilbene rattan soup that treating knee osteoarthritis, concrete operation step are as follows:
Step 1: prepare raw material, take raw Radix Astragali, Sargent gloryvine, Radix Angelicae Sinensis, caulis lonicerae, Pollen Typhae, radix cyathulae and Sheng Gan in proportion Grass is respectively shredded raw material using cutting machine after wind filter dedusting, and screen(ing) machine sieving later takes fines, stores particle using strap And beating is mixed, complete the preparation of pack;
Step 2: pack is put into casserole, and clear water cold soaking is added, and clear water floods pack and is higher by pack 3-5cm;
Step 3: after the completion of cold soaking, casserole is placed on to boil by intense fire on gas burner, is transferred to is cooked by slow fire later;
Step 4: clear water is continuously added in the decoction later period, and is put into honey, lemon tablet and dried peppermint leaf, is boiled again to soup Fire is closed after rising, and is covered and boiled in a covered pot over a slow fire to cooling pot temperature out;
Step 5: draining taking-up for pack, and filters the remnants of the impurity in decoction liquor, stilbene rattan soup is obtained, by stilbene rattan soup etc. Amount is divided equally, and aseptic canning, and placement stores in a cool and dry place.
Preferably, the mesh number of the screen(ing) machine is set as 40-50 mesh, and the mesh number of the strap is set as 90-100 mesh.
Preferably, clear water usage amount is 4-6 times of pack volume in the step 2, and soaking time is set as 45- 60min。
Preferably, discontinuity overturns pack in mild fire decoction process in the step 3, and squeezes pack with spoon.
Preferably, clear water additional amount is set as 150-200ml in the step 4, and the cooling temperature setting that takes the dish out of the pot is 30-40℃。
Preferably, magnitude is divided equally in the step 5 and is set as 100ml.
Technical effect and advantage of the invention:
1, by formula collocation, raw Radix Astragali has effects that solid table, torr sore and benefit water, can tonifying middle-Jiao and Qi, Sargent gloryvine has The effect of promoting blood circulation and stopping pain and dispelling wind and eliminating dampness, Radix Angelicae Sinensis have effects that replenishing and activating blood, and caulis lonicerae has effects that detumescence, promote bone group The effect of knitting reparation, Pollen Typhae have effects that hemostasia and dissipation blood stasis, and radix cyathulae has effects that stasis-dispelling and pain-killing, and licorice has QI invigorating The effect of bowl spares and coordinating the drug actions of a prescription, all medicine cooperations, which are adjusted, to fill blood, and dissolving stasis leads to numbness, has special effect to treatment knee osteoarthritis, in addition lemon Lemon piece can improve blood circulation, promote wound healing, keep bone, tissue and cartilage health, prevent osteoporosis, inhibit body Interior inflammation accelerates rehabilitation, and dried peppermint leaf and honey is added, makes soup fragrant odour, in good taste, moreover it is possible to improve the shelf-life of medicine soup;
2, by preparing pack, cold soaking, decoction, the processing step production stilbene rattan that clear water and blender and filtering packing is added Effective recovery rate of soup, medicinal material is high, improves effective component, can speed up sufferer rehabilitation, shortens medication cycle, reduces resource wave Take, and the processing is simple, it is easy to produce.
Specific embodiment
It is clearly and completely described below in conjunction with the technical solution in the embodiment of the present invention, it is clear that described reality Applying example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is general Logical technical staff every other embodiment obtained without making creative work belongs to what the present invention protected Range.
Embodiment 1:
The present invention provides a kind of formulas of stilbene rattan soup for treating knee osteoarthritis, wherein used major ingredient is by weight It include: raw Radix Astragali 58g, Sargent gloryvine 13g, Radix Angelicae Sinensis 8g, caulis lonicerae 13g, Pollen Typhae 8g, radix cyathulae 8g and licorice 5g.
It further, further include blender in the formula, the blender is made of honey, lemon tablet and dried peppermint leaf.
Further, the usage amount of the blender is respectively set are as follows: 2 spoons of honey, lemon tablet 2 and dried peppermint leaf 3;
A kind of preparation method of the formula of stilbene rattan soup that treating knee osteoarthritis, concrete operation step are as follows:
Step 1: prepare raw material, take raw Radix Astragali, Sargent gloryvine, Radix Angelicae Sinensis, caulis lonicerae, Pollen Typhae, radix cyathulae and Sheng Gan in proportion Grass is respectively shredded raw material using cutting machine after wind filter dedusting, and screen(ing) machine sieving later takes fines, and the mesh number of screen(ing) machine is set as 40 mesh store particle using strap and mix beating, and the mesh number of strap is set as 90 mesh, completes the preparation of pack;
Step 2: pack is put into casserole, and clear water cold soaking is added, and clear water usage amount is 4 times of pack volume, clear water It floods pack and is higher by pack 3cm, soaking time is set as 45min;
Step 3: after the completion of cold soaking, casserole being placed on to boil by intense fire on gas burner, is transferred to is cooked by slow fire later, mild fire Discontinuity overturns pack in decoction process, and squeezes pack with spoon;
Step 4: clear water is continuously added in the decoction later period, clear water additional amount is set as 150ml, and is put into honey, lemon tablet And dried peppermint leaf, fire is closed after soup boils again, and cover and boil in a covered pot over a slow fire to cooling pot temperature out, the cooling temperature setting that takes the dish out of the pot is 30 DEG C;
Step 5: draining taking-up for pack, and filters the remnants of the impurity in decoction liquor, stilbene rattan soup is obtained, by stilbene rattan soup etc. Amount is divided equally, and respectively magnitude is set as 100ml, and aseptic canning, and placement stores in a cool and dry place.
It is wrapped after stilbene rattan soup encapsulation with single as dose, detailed directions are as follows: each 1 time daily morning and evening, 1 bag every time, in meal It is warmly taken after 1 hour afterwards, and is for 14 times 1 course for the treatment of.
The stilbene rattan soup prepared in the present embodiment, medicinal ingredient is high, and drug effect is mild, does not stimulate, and fragrant, mouthfeel is slightly sweet, Dregs of a decoction residual component is detected after the completion of preparation, medicinal material effective component extraction rate is 93.6% as the result is shown, in addition originally Randomly choosed 10 rheumathritis patients in embodiment, treated according to the stilbene rattan soup that is prepared in the present embodiment, and to its into State of an illness follow-up investigation is gone, as the result is shown: patient keenly feels after medication to be eased, and slight sufferer is at continuous medication 4.5-5 After the course for the treatment of substantially can rehabilitation, finally, in the evaluation link of full marks very standard, 10 evaluation of patient average marks are 7 points.
Embodiment 2:
The present invention provides a kind of formulas of stilbene rattan soup for treating knee osteoarthritis, wherein used major ingredient is by weight It include: raw Radix Astragali 59g, Sargent gloryvine 14g, Radix Angelicae Sinensis 9g, caulis lonicerae 14g, Pollen Typhae 9g, radix cyathulae 9g and licorice 6g.
It further, further include blender in the formula, the blender is made of honey, lemon tablet and dried peppermint leaf.
Further, the usage amount of the blender is respectively set are as follows: 3 spoons of honey, lemon tablet 2 and dried peppermint leaf 3;
A kind of preparation method of the formula of stilbene rattan soup that treating knee osteoarthritis, concrete operation step are as follows:
Step 1: prepare raw material, take raw Radix Astragali, Sargent gloryvine, Radix Angelicae Sinensis, caulis lonicerae, Pollen Typhae, radix cyathulae and Sheng Gan in proportion Grass is respectively shredded raw material using cutting machine after wind filter dedusting, and screen(ing) machine sieving later takes fines, and the mesh number of screen(ing) machine is set as 45 mesh store particle using strap and mix beating, and the mesh number of strap is set as 95 mesh, completes the preparation of pack;
Step 2: pack is put into casserole, and clear water cold soaking is added, and clear water usage amount is 5 times of pack volume, clear water It floods pack and is higher by pack 4cm, soaking time is set as 50min;
Step 3: after the completion of cold soaking, casserole being placed on to boil by intense fire on gas burner, is transferred to is cooked by slow fire later, mild fire Discontinuity overturns pack in decoction process, and squeezes pack with spoon;
Step 4: clear water is continuously added in the decoction later period, clear water additional amount is set as 160ml, and is put into honey, lemon tablet And dried peppermint leaf, fire is closed after soup boils again, and cover and boil in a covered pot over a slow fire to cooling pot temperature out, the cooling temperature setting that takes the dish out of the pot is 35 DEG C;
Step 5: draining taking-up for pack, and filters the remnants of the impurity in decoction liquor, stilbene rattan soup is obtained, by stilbene rattan soup etc. Amount is divided equally, and respectively magnitude is set as 100ml, and aseptic canning, and placement stores in a cool and dry place.
It is wrapped after stilbene rattan soup encapsulation with single as dose, detailed directions are as follows: each 1 time daily morning and evening, 1 bag every time, in meal It is warmly taken after 1 hour afterwards, and is for 14 times 1 course for the treatment of.
Comparative example 1, the stilbene rattan soup prepared in the present embodiment, medicinal ingredient is high, and drug effect is mild, does not stimulate, and entrance is clear Perfume (or spice), mouthfeel is slightly sweet, detects after the completion of preparation to dregs of a decoction residual component, and medicinal material effective component extraction rate is as the result is shown 94.2%, 10 rheumathritis patients are in addition randomly choosed in the present embodiment, according to the stilbene rattan soup prepared in the present embodiment Treatment, and state of an illness follow-up investigation has been carried out to it, as the result is shown: patient keenly feels after medication to be eased, and slight sufferer is being held After continuous 4-4.5 course for the treatment of of medication substantially can rehabilitation, finally, in the evaluation link of full marks very standard, 10 evaluation of patient Average mark is 8 points.
Embodiment 3:
The present invention provides a kind of formulas of stilbene rattan soup for treating knee osteoarthritis, wherein used major ingredient is by weight It include: raw Radix Astragali 60g, Sargent gloryvine 15g, Radix Angelicae Sinensis 10g, caulis lonicerae 15g, Pollen Typhae 10g, radix cyathulae 10g, licorice 6g.
It further, further include blender in the formula, the blender is made of honey, lemon tablet and dried peppermint leaf.
Further, the usage amount of the blender is respectively set are as follows: 4 spoons of honey, lemon tablet 3 and dried peppermint leaf 4;
A kind of preparation method of the formula of stilbene rattan soup that treating knee osteoarthritis, concrete operation step are as follows:
Step 1: prepare raw material, take raw Radix Astragali, Sargent gloryvine, Radix Angelicae Sinensis, caulis lonicerae, Pollen Typhae, radix cyathulae and Sheng Gan in proportion Grass is respectively shredded raw material using cutting machine after wind filter dedusting, and screen(ing) machine sieving later takes fines, and the mesh number of screen(ing) machine is set as 45 mesh store particle using strap and mix beating, and the mesh number of strap is set as 95 mesh, completes the preparation of pack;
Step 2: pack is put into casserole, and clear water cold soaking is added, and clear water usage amount is 5 times of pack volume, clear water It floods pack and is higher by pack 4cm, soaking time is set as 55min;
Step 3: after the completion of cold soaking, casserole being placed on to boil by intense fire on gas burner, is transferred to is cooked by slow fire later, mild fire Discontinuity overturns pack in decoction process, and squeezes pack with spoon;
Step 4: clear water is continuously added in the decoction later period, clear water additional amount is set as 180ml, and is put into honey, lemon tablet And dried peppermint leaf, fire is closed after soup boils again, and cover and boil in a covered pot over a slow fire to cooling pot temperature out, the cooling temperature setting that takes the dish out of the pot is 35 DEG C;
Step 5: draining taking-up for pack, and filters the remnants of the impurity in decoction liquor, stilbene rattan soup is obtained, by stilbene rattan soup etc. Amount is divided equally, and respectively magnitude is set as 100ml, and aseptic canning, and placement stores in a cool and dry place.
It is wrapped after stilbene rattan soup encapsulation with single as dose, detailed directions are as follows: each 1 time daily morning and evening, 1 bag every time, in meal It is warmly taken after 1 hour afterwards, and is for 14 times 1 course for the treatment of.
Comparative example 1 and 2, the stilbene rattan soup prepared in the present embodiment, medicinal ingredient is high, and drug effect is mild, does not stimulate, entrance Faint scent, mouthfeel is slightly sweet, detects after the completion of preparation to dregs of a decoction residual component, and medicinal material effective component extraction rate is as the result is shown 94.3%, 10 rheumathritis patients are in addition randomly choosed in the present embodiment, according to the stilbene rattan soup prepared in the present embodiment Treatment, and state of an illness follow-up investigation has been carried out to it, as the result is shown: patient keenly feels after medication to be eased, and slight sufferer is being held After continuous 3-4 course for the treatment of of medication substantially can rehabilitation, finally, 10 evaluation of patient are put down in the evaluation link of full marks very standard Equal score is 10 points.
Embodiment 4:
The present invention provides a kind of formulas of stilbene rattan soup for treating knee osteoarthritis, wherein used major ingredient is by weight It include: raw Radix Astragali 62g, Sargent gloryvine 17g, Radix Angelicae Sinensis 12g, caulis lonicerae 17g, Pollen Typhae 12g, radix cyathulae 12g and licorice 7g.
It further, further include blender in the formula, the blender is made of honey, lemon tablet and dried peppermint leaf.
Further, the usage amount of the blender is respectively set are as follows: 5 spoons of honey, lemon tablet 3 and dried peppermint leaf 4;
A kind of preparation method of the formula of stilbene rattan soup that treating knee osteoarthritis, concrete operation step are as follows:
Step 1: prepare raw material, take raw Radix Astragali, Sargent gloryvine, Radix Angelicae Sinensis, caulis lonicerae, Pollen Typhae, radix cyathulae and Sheng Gan in proportion Grass is respectively shredded raw material using cutting machine after wind filter dedusting, and screen(ing) machine sieving later takes fines, and the mesh number of screen(ing) machine is set as 50 mesh store particle using strap and mix beating, and the mesh number of strap is set as 100 mesh, completes the preparation of pack;
Step 2: pack is put into casserole, and clear water cold soaking is added, and clear water usage amount is 6 times of pack volume, clear water It floods pack and is higher by pack 5cm, soaking time is set as 60min;
Step 3: after the completion of cold soaking, casserole being placed on to boil by intense fire on gas burner, is transferred to is cooked by slow fire later, mild fire Discontinuity overturns pack in decoction process, and squeezes pack with spoon;
Step 4: clear water is continuously added in the decoction later period, clear water additional amount is set as 200ml, and is put into honey, lemon tablet And dried peppermint leaf, fire is closed after soup boils again, and cover and boil in a covered pot over a slow fire to cooling pot temperature out, the cooling temperature setting that takes the dish out of the pot is 40 DEG C;
Step 5: draining taking-up for pack, and filters the remnants of the impurity in decoction liquor, stilbene rattan soup is obtained, by stilbene rattan soup etc. Amount is divided equally, and respectively magnitude is set as 100ml, and aseptic canning, and placement stores in a cool and dry place.
It is wrapped after stilbene rattan soup encapsulation with single as dose, detailed directions are as follows: each 1 time daily morning and evening, 1 bag every time, in meal It is warmly taken after 1 hour afterwards, and is for 14 times 1 course for the treatment of.
Comparative example 1-3, the stilbene rattan soup prepared in the present embodiment, medicinal ingredient is high, and drug effect is mild, does not stimulate, entrance Faint scent, mouthfeel is slightly sweet, detects after the completion of preparation to dregs of a decoction residual component, and medicinal material effective component extraction rate is as the result is shown 92.3%, 10 rheumathritis patients are in addition randomly choosed in the present embodiment, according to the stilbene rattan soup prepared in the present embodiment Treatment, and state of an illness follow-up investigation has been carried out to it, as the result is shown: patient keenly feels after medication to be eased, and slight sufferer is being held After continuous 3-4 course for the treatment of of medication substantially can rehabilitation, finally, 10 evaluation of patient are put down in the evaluation link of full marks very standard Equal score is 9 points.
Following table is obtained according to embodiment 1-4:
As seen from the above table, 3 chinese raw materials ratio of embodiment is moderate, and processing temperature is moderate, and process time is suitable for passing through the work The stilbene rattan soup of skill preparation, therapeutic effect is best, and raw Radix Astragali has effects that solid table, torr sore and sharp water in formula, being capable of bowl spares benefit Gas, Sargent gloryvine have effects that promoting blood circulation and stopping pain and dispelling wind and eliminating dampness, and Radix Angelicae Sinensis has effects that replenishing and activating blood, and caulis lonicerae has the function of detumescence The effect of effect, promotion bone tissue reparation, Pollen Typhae has effects that hemostasia and dissipation blood stasis, and radix cyathulae has effects that stasis-dispelling and pain-killing, raw Radix Glycyrrhizae has effects that invigorating middle warmer and replenishing QI and coordinating the drug actions of a prescription, and all medicine cooperations, which are adjusted, to fill blood, and dissolving stasis leads to numbness, has to treatment knee osteoarthritis Special effect, in addition lemon tablet can improve blood circulation, promote wound healing, keep bone, tissue and cartilage health, prevent sclerotin It is loose, inhibit internal inflammation, accelerate rehabilitation, dried peppermint leaf and honey is added, makes soup fragrant odour, it is in good taste, moreover it is possible to improve medicine The shelf-life of soup.
Finally, it should be noted that the foregoing is only a preferred embodiment of the present invention, it is not intended to restrict the invention, All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in of the invention Within protection scope.

Claims (10)

1. a kind of formula for the stilbene rattan soup for treating knee osteoarthritis, it is characterised in that: major ingredient used in wherein wraps by weight It includes: raw Radix Astragali 50-70g, Sargent gloryvine 10-20g, Radix Angelicae Sinensis 5-15g, caulis lonicerae 10-20g, Pollen Typhae 6-14g, radix cyathulae 6-14g and life Radix Glycyrrhizae 4-8g.
2. a kind of formula of stilbene rattan soup for treating knee osteoarthritis according to claim 1, it is characterised in that: wherein made Major ingredient includes: raw Radix Astragali 58-62g, Sargent gloryvine 13-17g, Radix Angelicae Sinensis 8-12g, caulis lonicerae 13-17g, Pollen Typhae 8- by weight 12g, radix cyathulae 8-12g and licorice 5-7g.
3. a kind of formula of stilbene rattan soup for treating knee osteoarthritis according to claim 1, it is characterised in that: the formula In further include blender, the blender is made of honey, lemon tablet and dried peppermint leaf.
4. a kind of formula of stilbene rattan soup for treating knee osteoarthritis according to claim 3, it is characterised in that: the reconciliation The usage amount of agent is respectively set are as follows: 2-5 spoons of honey, lemon tablet 2-3 piece and dried peppermint leaf 3-4 piece.
5. a kind of preparation method of the formula for the stilbene rattan soup for treating knee osteoarthritis, it is characterised in that: concrete operation step are as follows:
Step 1: prepare raw material, take raw Radix Astragali, Sargent gloryvine, Radix Angelicae Sinensis, caulis lonicerae, Pollen Typhae, radix cyathulae and licorice, wind in proportion Raw material is shredded respectively using cutting machine after power screening dedusting, screen(ing) machine sieving later takes fines, stores particle using strap and mixes It is in step with and beats, complete the preparation of pack;
Step 2: pack is put into casserole, and clear water cold soaking is added, and clear water floods pack and is higher by pack 3-5cm;
Step 3: after the completion of cold soaking, casserole is placed on to boil by intense fire on gas burner, is transferred to is cooked by slow fire later;
Step 4: clear water is continuously added in the decoction later period, and is put into honey, lemon tablet and dried peppermint leaf, after soup boils again Guan Huo, and cover and boil in a covered pot over a slow fire to cooling pot temperature out;
Step 5: draining taking-up for pack, and filters the remnants of the impurity in decoction liquor, obtains stilbene rattan soup, and stilbene rattan soup equivalent is equal Point, and aseptic canning, placement store in a cool and dry place.
6. a kind of preparation method of the formula of stilbene rattan soup for treating knee osteoarthritis according to claim 5, feature exist In: the mesh number of the screen(ing) machine is set as 40-50 mesh, and the mesh number of the strap is set as 90-100 mesh.
7. a kind of preparation method of the formula of stilbene rattan soup for treating knee osteoarthritis according to claim 5, feature exist In: clear water usage amount is 4-6 times of pack volume in the step 2, and soaking time is set as 45-60min.
8. a kind of preparation method of the formula of stilbene rattan soup for treating knee osteoarthritis according to claim 5, feature exist In: discontinuity overturns pack in mild fire decoction process in the step 3, and squeezes pack with spoon.
9. a kind of preparation method of the formula of stilbene rattan soup for treating knee osteoarthritis according to claim 5, feature exist In: clear water additional amount is set as 150-200ml in the step 4, and the cooling temperature setting that takes the dish out of the pot is 30-40 DEG C.
10. a kind of preparation method of the formula of stilbene rattan soup for treating knee osteoarthritis according to claim 5, feature exist In: divide equally magnitude in the step 5 and is set as 100ml.
CN201910608083.5A 2019-07-08 2019-07-08 A kind of formula and preparation method thereof of stilbene rattan soup that treating knee osteoarthritis Pending CN110179897A (en)

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CN103536777A (en) * 2013-10-26 2014-01-29 荣成市科学技术情报研究所 Traditional Chinese medicinal composition for treating knee osteoarthritis
CN103655768A (en) * 2013-12-10 2014-03-26 柳州市中医院 Traditional Chinese medicine for treating clod-dampness gonitis, and preparation method thereof
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Application publication date: 20190830