CN110179853A - A kind of traditional Chinese medicine composition for herpes - Google Patents
A kind of traditional Chinese medicine composition for herpes Download PDFInfo
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- CN110179853A CN110179853A CN201910597340.XA CN201910597340A CN110179853A CN 110179853 A CN110179853 A CN 110179853A CN 201910597340 A CN201910597340 A CN 201910597340A CN 110179853 A CN110179853 A CN 110179853A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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Abstract
The invention discloses a kind of drugs and preparation method thereof for treating shingles zoster, by weight, including following bulk pharmaceutical chemicals: full 30-50 parts of Snakegourd Fruit, 10-20 parts of Radix Isatidis, 10-15 parts of Radix Angelicae Sinensis, 5-10 parts of licorice, 3-6 parts of safflower.Preparation method: Chinese medicine composition is boiled medicine according to a conventional method, is decocted 2 times, is mixed, point 2 oral, one dose per day, 5 days as a treatment course.Drug of the invention has the characteristics that rapid-action, good effect to treatment shingles zoster, does not stay pain sequelae, safe without toxic side effect, and preparation method is simple, easy to use.Clinical 80 patients use, total effective rate 100%, cure rate 90%.
Description
Technical field
The present invention relates to a kind of traditional Chinese medicine composition for herpes, belong to technical field of traditional Chinese medicines.
Background technique
Shingles zoster is brought back to life by latent varicella-herpes zoster virus (Varicella-zostervirus, VZV)
Caused one kind disease.VZV mainly invades skin and local nerve, shows as band-like, the cluster water being distributed along Transcutaneous
Blister, often with the severe pain at the dominated position of involvement nerve.Shingles zoster annual morbidity is about 3%~5% according to statistics, and often hair is in height
Age, hypoimmunity crowd.Post-herpetic neuralgia (Postherpetic neuralgia, PHN) is shingles zoster hair
The raw highest complication of rate, belongs to intractable pain disease.PHN can occur for 60 years old or more shingles zoster patients about 65%,
70 years old and the above person are then up to 75%.PHN will cause to seriously affect to the physical and mental health of patient, increase daily life and work
The puzzlement of work.At present doctor trained in Western medicine mostly use corticosteroid hormone, antiviral, trophic nerve, analgesic to suit the medicine to the illness, immunomodulator and anti-
Herpesviral method, but the course of disease is long, costly, Yi Fasheng PHN, and side effect is also big.And traditional Chinese medicine is in terms for the treatment of shingles zoster
There is unique advantage, curative for effect, Small side effects.
From the point of view of the prior art, although had it is various treatment shingles zosters Chinese prescriptions include applied it is special
Benefit, but used Chinese medicine flavour of a drug are excessively many and diverse, to liver kidney heavy load, and curative effect is unsatisfactory.
The purpose of the present invention is to provide the special for the treatment of shingles zoster that is a kind of to simple, extremely honest and clean, having no toxic side effect to effect
Sick specially side.Chinese medicine is cured the disease using dialectical treatmert as fundamental law, and specific prescription for certain illness is the essence of Chinese medicine." the folk prescription gas simply so have
Dead name doctor's says ".Shingles zoster subordination is contained in Liver Channel fire, and card type is single, can be reduced to debate disease treatment, using specific prescription for certain illness, letter
It is single, efficient.The present invention, only 5 taste, rapid-action, good effect lose neuralgia, convenient to take, price without sequelae to prescription flavour of a drug
It is cheap, it is free from side effects, has highlighted Chinese medicine letter, feature just, honest and clean.
Summary of the invention
The purpose of the present invention is to provide a kind of drugs for treating shingles zoster, by weight, including following bulk pharmaceutical chemicals:
Full 30-50 parts of Snakegourd Fruit, 10-20 parts of Radix Isatidis, 10-15 parts of Radix Angelicae Sinensis, 5-10 parts of licorice, 3-6 parts of safflower.
A kind of drug for treating shingles zoster of the invention, by weight, including following bulk pharmaceutical chemicals:
Complete 50 parts of Snakegourd Fruit, 20 parts of Radix Isatidis, 15 parts of Radix Angelicae Sinensis, 10 parts of licorice, 6 parts of safflower.
A kind of drug for treating shingles zoster of the invention, by weight, including following bulk pharmaceutical chemicals:
Complete 40 parts of Snakegourd Fruit, 15 parts of Radix Isatidis, 12 parts of Radix Angelicae Sinensis, 6 parts of licorice, 5 parts of safflower.
A kind of drug for treating shingles zoster of the invention, by weight, including following bulk pharmaceutical chemicals:
Complete 30 parts of Snakegourd Fruit, 10 parts of Radix Isatidis, 10 parts of Radix Angelicae Sinensis, 5 parts of licorice, 3 parts of safflower.
The preparation method of the traditional Chinese medicine composition for herpes is made of: Chinese medicinal preparation method routinely
Suitable for medicinal oral drugs.Chinese medicine composition is also possible to granule, tablet, pill and capsule etc..
Each taste property of traditional Chinese of the traditional chinese medicine composition of the invention, taste, channel tropism, effect, cure mainly it is as follows:
Full Snakegourd Fruit nature and flavor are sweet, slight bitter, tremble with fear.Return lung, stomach, large intestine channel.Function clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, ease constipation.For lung heat cough
It coughs, yellow and thick phlegm, chest impediment and cardialgia, acute mastitis, pulmonary abscess, acute appendicitis swelling and pain." Chongqing hall random notes " meaning: " Chinese juniper beach wormwood is real, moisturizes out knot, swings heat
Phlegm is washed, madam knows it；And do not know its liver depression of relaxing, profit liver is dry, and calming the liver is inverse, and the function of slow liver urgency, which has, solely arrogates to oneself, (Wei) Mr. Yu Huang speech
Most in detail." Ming Dynasty " Medicine Comprehended " snakegourd (Snakegourd Fruit) dissipates, original text is said: " snakegourd dissipates, and controls that irritability is restless and hypochondriac pain, or shampoo blister ".
Isatis root, it is bitter in taste, cold.Return heart, stomach.Major function is clearing heat and detoxicating, cool blood relieving sore-throat.For febrile virulent maculae, tongue is deep red
It is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle swells." Chinese medicinal herbal ": " Qinghuo Jiedu, cooling blood and hemostasis.Control pyreticosis
Macular eruption, erysipelas, abscess of throat, the diseases such as infection with swollen head, and haematemesis, bleeding from five sense organs or subcutaneous tissue."
Licorice nature and flavor sweet and neutral.Return heart, lung, spleen, stomach meridian.Major function is invigorated the spleen and benefited qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, emergency
Analgesic, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, stomach duct and abdomen, four limbs contraction, carbuncle swells
Sore alleviates drug toxicity, strong.
Radix Angelicae Sinensis, nature and flavor sweet, acrid, warm.Return liver, the heart, the spleen channel.Function benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizing dryness and lubricating intestine.Control menstruation
Uncomfortable, menostasis abdominal pain, abdominal mass knot is poly-, metrorrhagia and metrostaxis；Headache due to deficiency of blood, dizziness, flaccidity syndrome and arthralgia syndrome；Intestines are dry and shit is difficult, weight after dysentery with bloody stool；Ulcer sore is stolen, and is fallen
Flutter damage.
Safflower acrid flavour, it is warm-natured.Channel tropism converge to heart and liver channels.Effect blood circulation, removing blood stasis and acesodyne.It cures mainly for menostasis, dysmenorrhea,
Lochia, abdominal mass lump in the abdomen, chest impediment and cardialgia, stasis of blood, pricking pain in the chest, injury from falling down, sore swell and ache curative.
The present composition is formulated using 5 kinds of natural Chinese medicinal herbs, and Snakegourd Fruit relaxes liver depression, and profit liver is dry, and calming the liver is inverse, slow liver
It is anxious；Isatis root, clearing heat and detoxicating, cool blood；Licorice is clearing heat and detoxicating, in sweet mitigation, can prevent Snakegourd Fruit from letting out benefit and too hurt just；When
Return, safflower disperse blood stasis and dredge collateral.All medicines share, gathers easypro liver depression altogether, and profit liver is dry, and calming the liver is inverse, delays the effect of liver is anxious, securely and reliably, takes
After have no adverse reaction, be worthy of popularization.
Specific embodiment
The beneficial effect of the present invention will be further illustrated by the following test examples the drug.
Test example: the clinical observation of drug of the present invention
1. clinical data:
Medical patient's treatment is randomly divided into 2 groups according to parity packet method, each 80 of observation group, control group, wherein observation group: male
40, female 40, the age 18 ~ 75 years old, average (43.2 ± 5.3) year, average onset time (3.33 ± 0.62) d.
Control group 80, male 43, female 37, the age 18 ~ 75 years old, average age (44.5 ± 5.6) year, it is average
Disease time (3.52 ± 0.55) d.The comparing differences such as two groups of genders, age, the morbidity course for the treatment of are not statistically significant, there is comparativity.
2. Disease Diagnosis Standard
Doctor trained in Western medicine diagnosis is referring to " skin cypridology " to the regulation of shingles zoster.(1) privileged site burst in patient body unilateral side is strong
Feeling of pain；(2) blister cluster is in closely omphalos shape, and substrate flush gos deep into skin, and blister wall matter is hard.
3. being included in standard meets the above diagnostic criteria, and the age 18 ~ 75 years old, the course of disease≤4 d.
4. exclusion criteria merges the severe primaries Diseases such as cardio-cerebrovascular, liver kidney system and hemopoietic system；It closes
And diseases and the state of an illness critical patient such as serious nephrosis, diabetes, AIDS；It is controlled for a long time using glucocorticoid, immunosuppressor
Treatment person；Merge severe psychiatric class disease and clinical treatment fitness chump.
5. treatment method:
Drug is decocted into decoction and is taken by Chinese medicine composition of the invention by traditional decocting medicine mode, even decocts twice, and medical fluid mixing is equal
Even point of morning and evening takes twice, and daily 1 pair, 5 days are 1 course for the treatment of.
5.1 control groups are given ganciclovir for injection (Yangtze River medicine company, specification: 10 mL:250 mg), intravenous infusion, and 250
Mg/ times, 1 time/d；Mecobalamin capsules (Yangtze River medicine company, specification: 0.5 mg/) oral medication is given, dosage: 0.5 mg/ times,
3 times/d；Thiamine Hydrochloride Tablets (Dongbei Pharmaceutical General Factory, specification: 10 mg) oral medication is given, dosage: 10 mg/ time, 3 times/d；With
Upper continuous 5 d of medication.
Oral medicinal herb is given by 5.2 treatment groups, prescription: Snakegourd Fruit 50g, Radix Isatidis 20g, Radix Angelicae Sinensis 15g, Radix Glycyrrhizae 6g, safflower 3g,
It daily 1 dose, is used in conjunction 5 days.
6. observation index (1) symptom extinction time compares: when counting erythema regression time after two groups of patients treat, only blister
Between, scab forming time, analgesic time.(2) pain scores: using the pretherapy and post-treatment pain of visual analogue scales (VAS) measurement patient
Pain degree, totally 10 points, 0 is painless, and 10 be most pain, and score is higher, and pain is more violent.(5) pain condition: right after treatment end
Patient carries out follow-up in 3 months by a definite date, and a situation arises for two groups of post herpetic neuralgias of statistics.(6) safety analysis: observation patient's treatment
Period routine, routine urinalysis and hepatic and renal function situation of change, a situation arises for statistics adverse reaction.
7. curative effect determinate standard
Referring to the criterion of therapeutical effect in Standards for Diagnosis and Curative Effect of Chinese Medical Symptom.Cure: after treatment, lesions of patients all subsides, part
Pain disappears, and therapeutic index is not less than 90%；Effective: after treatment, patient's major part skin lesion is subsided, and local pain is significantly delayed
Solution, therapeutic index 60% ~ 89%；Invalid: after treatment, lesions of patients, pain symptom do not obtain any improvement, and therapeutic index is insufficient
30%.Therapeutic index=(index after index-treatment before treating)/index × 100% before treating.
8. this research the data obtained of statistical method is all made of 22.0 statistical software of SPSS and is handled, measurement data
It is indicated in the form of (average ± standard deviation), is examined using t；Enumeration data indicates that class count data compares with percentage (%)
It is that difference is statistically significant with P < 0.05 using rank sum test.
9. treatment results:
After 9.1 two groups of treatments after Clinical efficacy comparison treatment, treatment group's total effective rate is 100%, is significantly higher than control group
76%, treatment group is better than control group (P < 0.05).(see Table 1)
Clinical efficacy comparison [example (%)] after 1 two groups of treatments of table
| Group | Number of cases | It cures | It is effective | In vain | Total effective rate |
| Treatment group | 80 | 72(90.0) | 8(10.0) | 0(0.0) | 80(100.0)a |
| Control group | 80 | 54(67.5) | 7(8.8) | 19(23.8) | 61(76.3) |
Note: compared with the control group, a P < 0.05.
After symptom extinction time compares treatment after 9.2 two groups of treatments, treatment group's erythema regression time, only blister time, knot
Scab time, analgesic time are substantially less than control group (P < 0.05).(see Table 2)
Symptom extinction time compares (x ± s, d) after 2 two groups of treatments of table
| Group | Number of cases | Erythema regression time | The only blister time | Scab forming time | Analgesic time |
| Treatment group | 80 | 1.02±0.51a | 1.53±0.65a | 2.02±0.53a | 1.51±0.66a |
| Control group | 80 | 3.40±0.72 | 4.23±0.75 | 4.93±0.61 | 4.93±0.62 |
Note: compared with the control group, a P < 0.05.
9.3 two groups after post herpetic neuralgia incidence treatment end 3 months, treatment group's post herpetic neuralgia incidence is significantly low
In control group (P < 0.05).(see Table 3)
3 two groups of post herpetic neuralgia incidences of table
| Group | Number of cases | Number of cases occurs for post herpetic neuralgia | Incidence (%) |
| Treatment group | 80 | 0 | 0.0a |
| Control group | 80 | 9 | 11.3 |
Note: compared with the control group, a P < 0.05.
Blood routine, routine urinalysis and hepatic and renal function have no significant change during 9.4 two groups of safety analysis patients treat.It controls
Treatment group generally has loose watery stool during treatment, and bowel frequency increases.
It is any in the range of not departing from spirit of the invention, utilize made by disclosed technology contents part
The equivalent embodiment for changing or modifying, and without departing from the technical feature content of spirit of the invention, still fall within the present invention
In the range of technical characteristic.
Claims (5)
1. a kind of Chinese medicine composition, it is characterised in that the raw material of the Chinese medicine composition forms are as follows: by weight, including it is following
Bulk pharmaceutical chemicals:
Full 30-50 parts of Snakegourd Fruit, 10-20 parts of Radix Isatidis, 10-15 parts of Radix Angelicae Sinensis, 5-10 parts of licorice, 3-6 parts of safflower.
2. a kind of traditional Chinese medicine composition for herpes according to claim 1, it is characterised in that the Chinese medicine composition
Raw material composition are as follows:
Including following bulk pharmaceutical chemicals: complete 50 parts of Snakegourd Fruit, 20 parts of Radix Isatidis, 15 parts of Radix Angelicae Sinensis, 10 parts of licorice, 6 parts of safflower.
3. a kind of traditional Chinese medicine composition for herpes according to claim 1, by weight, including following raw material
Medicine:
Complete 40 parts of Snakegourd Fruit, 15 parts of Radix Isatidis, 12 parts of Radix Angelicae Sinensis, 6 parts of licorice, 5 parts of safflower.
4. a kind of traditional Chinese medicine composition for herpes according to claim 1, by weight, including following bulk pharmaceutical chemicals:
Complete 30 parts of Snakegourd Fruit, 10 parts of Radix Isatidis, 10 parts of Radix Angelicae Sinensis, 5 parts of licorice, 3 parts of safflower.
5. Chinese medicine composition described in claim 1 or 2 or 3 or 4 is applied in preparation treatment shingles medications,
It is characterized in: samples by weight, Chinese medicinal preparation method routinely is made suitable for medicinal oral drugs；Chinese medicine composition
It can be granule, tablet, pill and capsule etc..
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526307A (en) * | 2012-02-16 | 2012-07-04 | 王建中 | Chinese medicinal composition for treating herpes zoster |
| CN104288597A (en) * | 2014-09-19 | 2015-01-21 | 魏绍良 | Traditional Chinese medicine composition for treating herpes zoster |
| CN106963796A (en) * | 2017-03-31 | 2017-07-21 | 张传军 | Treat the Chinese medicine of herpes zoster |
-
2019
- 2019-07-04 CN CN201910597340.XA patent/CN110179853A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526307A (en) * | 2012-02-16 | 2012-07-04 | 王建中 | Chinese medicinal composition for treating herpes zoster |
| CN104288597A (en) * | 2014-09-19 | 2015-01-21 | 魏绍良 | Traditional Chinese medicine composition for treating herpes zoster |
| CN106963796A (en) * | 2017-03-31 | 2017-07-21 | 张传军 | Treat the Chinese medicine of herpes zoster |
Non-Patent Citations (3)
| Title |
|---|
| 杨海芳: "中西医结合治疗带状疱疹的观察与护理", 《现代中西医结合杂志》 * |
| 梁玉瑛等: "瓜蒌红花甘草汤治疗带状疱疹31例", 《新中医》 * |
| 黎崇裕: "《一个青年中医之路 从经方庙堂到民间江湖》", 31 August 2016, 中国中医药出版社 * |
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