CN110051751A - Datura flower asthma relieving powder broken wall superfine powder and its preparation process - Google Patents
Datura flower asthma relieving powder broken wall superfine powder and its preparation process Download PDFInfo
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- CN110051751A CN110051751A CN201910360147.4A CN201910360147A CN110051751A CN 110051751 A CN110051751 A CN 110051751A CN 201910360147 A CN201910360147 A CN 201910360147A CN 110051751 A CN110051751 A CN 110051751A
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- 239000000843 powder Substances 0.000 title claims abstract description 69
- 241000208296 Datura Species 0.000 title claims abstract description 47
- 208000006673 asthma Diseases 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 22
- 229940037003 alum Drugs 0.000 claims abstract description 15
- 229910052602 gypsum Inorganic materials 0.000 claims abstract description 14
- 239000010440 gypsum Substances 0.000 claims abstract description 14
- 241001465251 Ephedra sinica Species 0.000 claims abstract description 13
- 210000000582 semen Anatomy 0.000 claims abstract description 11
- 230000000694 effects Effects 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 210000002421 cell wall Anatomy 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims description 27
- 238000000498 ball milling Methods 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 8
- 238000000855 fermentation Methods 0.000 claims description 8
- 230000004151 fermentation Effects 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 244000063299 Bacillus subtilis Species 0.000 claims description 7
- 235000014469 Bacillus subtilis Nutrition 0.000 claims description 7
- 108010059892 Cellulase Proteins 0.000 claims description 7
- 229940106157 cellulase Drugs 0.000 claims description 7
- 239000010907 stover Substances 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
- 235000008216 herbs Nutrition 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- 239000004376 Sucralose Substances 0.000 claims description 2
- 239000011324 bead Substances 0.000 claims description 2
- 235000019645 odor Nutrition 0.000 claims description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 2
- 235000019408 sucralose Nutrition 0.000 claims description 2
- 244000144725 Amygdalus communis Species 0.000 claims 2
- 235000011437 Amygdalus communis Nutrition 0.000 claims 2
- 235000020224 almond Nutrition 0.000 claims 2
- 244000144972 livestock Species 0.000 abstract description 7
- 244000144977 poultry Species 0.000 abstract description 5
- 239000007962 solid dispersion Substances 0.000 abstract description 2
- 241000411851 herbal medicine Species 0.000 description 9
- 238000004090 dissolution Methods 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 229940124584 antitussives Drugs 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229960000502 poloxamer Drugs 0.000 description 2
- 229920001983 poloxamer Polymers 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000003688 hormone derivative Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/14—Antitussive agents
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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Abstract
The invention discloses a kind of datura flower asthma relieving powder broken wall superfine powder and its preparation processes, datura flower asthma relieving powder ultramicro powder include cell wall three groups of raw materials of datura flower, Chinese ephedra, semen armeniacae amarae and gypsum, alum auxiliary material through abundant broken wall treatment, and datura flower, Chinese ephedra, semen armeniacae amarae, gypsum, alum weight fraction ratio be (6-12): (2-6): (3-9): (10-20): (3-8).The present invention has opened poultry datura flower asthma relieving powder novel form by efficient solid dispersion technology, improves the scope of application and application effect that datura flower asthma relieving is dispersed in livestock culture industry.
Description
Technical field
The present invention relates to livestock culture technical field more particularly to it is a kind of relieving asthma for poultry, the datura flower asthma relieving powder of cough-relieving
And its circulation crushes biological ferment ball milling broken wall preparation process.
Background technique
Currently, the use of Chinese herbal medicine is increasingly extensive in livestock culture industry.Relative to antibiotic and chemical synthetic drug
And hormone medicine, Chinese medicine have its specific advantage.But Chinese herbal medicine also has many defects, and ratio is especially showed in terms of dosage form
More prominent such as not soluble in water, degree of being absorbed and utilized difference.
Datura flower asthma relieving powder be applied at present domestic animal relieving asthma, cough-relieving, bulk pharmaceutical chemicals include datura flower, Chinese ephedra, semen armeniacae amarae, stone
Powder is generally made in cream, alum after coarse crushing, and safety and validity have been verified, and is administered to livestock culture
Industry feasibility with higher；But there are dosage forms it is thick, effective component dissolution and release efficiency is low the deficiencies of, seriously affect
The application effect of datura flower asthma relieving powder and treat range.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of datura flower asthma relieving powder broken wall superfine powder, dry mixed suspension preparation and its
Preparation process opens poultry datura flower asthma relieving powder novel form by efficient solid dispersion technology, improves datura flower asthma relieving and is dispersed in
The scope of application and application effect of livestock culture industry.
In order to solve the above technical problems, the technical solution used in the present invention is as follows.
Datura flower asthma relieving powder broken wall superfine powder, the Ultramicro-powder include datura flower of the cell wall through abundant broken wall treatment, Chinese ephedra,
Three groups of raw materials of semen armeniacae amarae and gypsum, alum auxiliary material, and datura flower, Chinese ephedra, semen armeniacae amarae, gypsum, alum weight fraction ratio be (6-
12):(2-6):(3-9):(10-20):(3-8)。
As a preferred technical solution of the present invention, the datura flower, Chinese ephedra, semen armeniacae amarae, gypsum, alum weight fraction ratio
For (8-10): (3-5): (5-7): (13-17): (4-6).
As a preferred technical solution of the present invention, the datura flower, Chinese ephedra, semen armeniacae amarae, gypsum, alum parts by weight
Number is than being 9:4:6:15:5.
Datura flower asthma relieving powder superfine powder is added poloxamer, mannitol, trichlorine by the dry-mixed suspended powder of datura flower asthma relieving powder broken wall
Sucrose, odor mask are mixed well, and dry-mixed suspended powder is obtained.
The circulation of datura flower asthma relieving powder crushes biological ferment ball milling broken wall preparation process, includes the following steps:
A, it recycles disintegrating process: being sent into pulverizer after three groups of Chinese medicine stocks are dry, pressure fan is set in the feed inlet of pulverizer,
Chinese medicine is blown into the smashing portion of pulverizer by air-flow, the mesh screen of 100-500 mesh is set in the discharge port end of smashing portion,
Return fan is set on the outside of mesh screen, and the blast pressure of this return fan intermittently starting, the blast pressure pressure fan is higher by 10-
50%；Traditional Chinese medicinal material raw materials are sent into after pulverizer, 100-500 mesh mesh screen was crushed to by the effect circulation of return fan, obtains Chinese medicine
Material powder；
B, zymotechnique: using the flora being made of stover ferment agent, bacillus subtilis and adding cellulase and brown sugar, controls
30-40 DEG C of fermentation temperature processed, pH value 5.0-7.0, moisture content 35-60% w/w, Chinese medicine powder obtained by step A is carried out normal
Pressure ferment continues 12-48 hours, adjusts pH value to neutrality, drying obtains Chinese medicine ferment material；
C, ball milling technology for broken wall: small-sized ball mill is selected, and using 0.5-2.5mm microballon to Chinese medicine ferment material obtained by step B
Friction feeding crushing is carried out, products therefrom is the traditional Chinese herbs broken wall material through abundant broken wall；
D, addition obtained by upper step was fully ground gypsum, the alum powder of 300 meshes, obtained datura flower asthma relieving powder broken wall Ultramicro-powder
Agent.
As a preferred technical solution of the present invention, in step A, the return fan is opened at interval of 0.5-1.5min interval
It opens, continues 5-15s after starting every time and be again switched off；Iterative cycles.
As a preferred technical solution of the present invention, in step A, the net of 200 mesh is set in the discharge port end of smashing portion
Sieve.
As a preferred technical solution of the present invention: in step A, the air blast of the blast pressure pressure fan
Pressure is higher by 30%；Return fan continues 15s after starting every time and is again switched off；Or the drum of the blast pressure pressure fan
Wind pressure is higher by 50%；Return fan continues 5s after starting every time and is again switched off.
As a preferred technical solution of the present invention, in step B, stover ferment agent, bacillus subtilis are before use
It is sufficiently activated in 35 DEG C of brown sugar water first, so that viable bacteria number reaches 10,000,000,000/CFU or more；Bacterium solution after activated, in
Medicinal material powder, brown sugar, cellulase weight fraction ratio be (35-70): (20-40): (10-20): (0.1-1) w/w.
As a preferred technical solution of the present invention, in step B, drying temperature is not higher than 65 DEG C；It blows in drying
To accelerate drying rate；In step B, pH adjusting is carried out using acetic acid, sodium carbonate, sodium bicarbonate system；In step B, normal pressure
Fermentation 20-40 hours.
As a preferred technical solution of the present invention, in step C, bead diameter 0.6-1.6mm；Product crosses 300 mesh
Sieve.
The beneficial effects of adopting the technical scheme are that the circulation disintegrating process that the present invention researches and develops, due to
Return fan is set on the outside of mesh screen, and the blast pressure of this return fan intermittently starting, the blast pressure pressure fan is higher by 10-
50%, the circulation that can be realized traditional Chinese medicinal material raw materials crushes, until obtaining the powder of target fineness by mesh screen；The present invention is recycling
On the basis of disintegrating process, further innovation uses ball milling technology for broken wall, selects small-sized ball mill, and use 0.5-
2.5mm microballon to Chinese medicinal herbs carry out friction feeding crushing, can be realized the abundant broken wall of Chinese herbal medicine cell, improve its effectively at
The release rate divided；In order to further increase the release efficiency of shell-broken effect and Chinese herbal medicine effective ingredients, the present invention is in ball milling broken wall
Before processing, a degree of fermentation process also has been carried out to Chinese herbal medicine, i.e., has been formed using stover ferment agent, bacillus subtilis
Flora and add cellulase and brown sugar, control temperature, pH value, moisture to traditional Chinese medicine powder material carry out normal pressure fermentation, this is one
Fermentation process that kind is slight, the shell-broken effect for promoting Chinese herbal medicine have positive effect.
In the prior art, datura flower asthma relieving powder is that each material composition mixes preparation after simple coarse crushing, and the present invention is ground
Effect is very significant compared with prior art for the technique of hair, and the dissolution and absorption efficiency of drug greatly improved, improve medium-height grass
The bioavilability of medicine has effectively expanded the scope of application and application effect that datura flower asthma relieving is dispersed in livestock culture industry.
Specific embodiment
The present invention is described in detail in following embodiment.Various raw materials used in the present invention and items of equipment are conventional city
Product is sold, can be bought and be directly obtained by market.
Embodiment 1, datura flower asthma relieving powder broken wall solid Ultramicro-powder.
The datura flower asthma relieving powder broken wall solid Ultramicro-powder of the present embodiment, the Ultramicro-powder include cell wall through abundant broken wall treatment
Datura flower, Chinese ephedra, three groups of raw materials of semen armeniacae amarae and gypsum, alum auxiliary material, and datura flower, Chinese ephedra, semen armeniacae amarae, gypsum, alum weight
Amount portion rate is 9:4:6:15:5；It is mainly used for poultry antiasthmatic-antitussive.
Embodiment 2, the dry mixed suspension preparation of datura flower asthma relieving powder broken wall.
Superfine powder in embodiment 1 is added into poloxamer, mannitol, Sucralose, odor mask, through mixing well,
Dry-mixed suspended powder is obtained, poultry antiasthmatic-antitussive is used for.
The circulation disintegrating process of embodiment 3, datura flower asthma relieving powder.
Circulation disintegrating process: being sent into pulverizer after three groups of Chinese medicine stocks are dry, and air-supply is arranged in the feed inlet of pulverizer
Chinese medicine is blown into the smashing portion of pulverizer by air-flow by machine, mesh screen is arranged in the discharge port end of smashing portion, on the outside of mesh screen
Return fan is set, and return fan is higher by 30% compared with the blast pressure of pressure fan at interval of 1 min intermittently starting, blast pressure, returns
Blower continues 15s after starting every time and is again switched off, iterative cycles；By the work after traditional Chinese medicinal material raw materials feeding pulverizer by return fan
It was crushed to 200-300 mesh mesh screen with circulation, obtains Chinese medicine powder.
Embodiment 4, broken wall pre-treatment --- slight zymotechnique.
Slight zymotechnique: using the flora that is made of stover ferment agent, bacillus subtilis and add cellulase and
Brown sugar controls 35 DEG C of fermentation temperature, pH value 5.0-7.0, moisture content 40-52% w/w, carries out to gained Chinese medicine powder normal
Pressure ferment continues 30 hours；Wherein, stover ferment agent, bacillus subtilis are filled in 35 DEG C of brown sugar water first using preceding
Divide activation, so that viable bacteria number reaches 10,000,000,000/CFU or more；Bacterium solution, Chinese medicine powder after activated, brown sugar, cellulase
Weight fraction ratio be 50:25:10:0.5 w/w；After fermentation, pH value is adjusted to neutrality, and 65 DEG C to dry side air-supply below
Flash baking is completed, Chinese medicine ferment material is obtained.
Embodiment 5, ball milling technology for broken wall.
Small-sized ball mill is selected, and friction feeding crushing, product are carried out to gained Chinese medicine ferment material using 1.2mm microballon
300-500 mesh is crossed, the traditional Chinese herbs broken wall material through abundant broken wall is obtained.
Innovative development of the present invention and cooperates circulation to crush+slight ferment for the unique ball-milling technology of Chinese herbal medicine
Pre-treating technology can be realized the high efficiency broken wall treatment of Chinese herbal medicine, and the dissolution and absorption efficiency of drug greatly improved, and improve
The bioavilability of Chinese herbal medicine has effectively expanded the scope of application and application effect that datura flower asthma relieving is dispersed in livestock culture industry
Fruit.
Foregoing description is only proposed as the enforceable technical solution of the present invention, not as to the single of its technical solution itself
Restrictive condition.
Claims (10)
1. datura flower asthma relieving powder broken wall superfine powder, it is characterised in that: the Ultramicro-powder includes ocean of the cell wall through abundant broken wall treatment
Golden flower, Chinese ephedra, three groups of raw materials of semen armeniacae amarae and gypsum, alum auxiliary material, and datura flower, Chinese ephedra, semen armeniacae amarae, gypsum, alum weight
Portion rate is (6-12): (2-6): (3-9): (10-20): (3-8).
2. datura flower asthma relieving powder broken wall superfine powder according to claim 1, it is characterised in that: the datura flower, Chinese ephedra, hardship
Almond, gypsum, alum weight fraction ratio be (8-10): (3-5): (5-7): (13-17): (4-6).
3. datura flower asthma relieving powder broken wall superfine powder according to claim 1, it is characterised in that: the datura flower, Chinese ephedra, hardship
Almond, gypsum, alum weight fraction ratio be 9:4:6:15:5.
4. the dry-mixed suspended powder of datura flower asthma relieving powder broken wall, it is characterised in that: the superfine powder addition pool Lip river in claim 1 is husky
Nurse, mannitol, Sucralose, odor mask are mixed well, and dry-mixed suspended powder is obtained.
5. the circulation of datura flower asthma relieving powder crushes biological ferment ball milling broken wall preparation process, it is characterised in that: the preparation process includes
Following steps:
A, it recycles disintegrating process: being sent into pulverizer after three groups of Chinese medicine stocks are dry, pressure fan is set in the feed inlet of pulverizer,
Chinese medicine is blown into the smashing portion of pulverizer by air-flow, the mesh screen of 100-500 mesh is set in the discharge port end of smashing portion,
Return fan is set on the outside of mesh screen, and the blast pressure of this return fan intermittently starting, the blast pressure pressure fan is higher by 10-
50%；Traditional Chinese medicinal material raw materials are sent into after pulverizer, 100-500 mesh mesh screen was crushed to by the effect circulation of return fan, obtains Chinese medicine
Material powder；
B, zymotechnique: using the flora being made of stover ferment agent, bacillus subtilis and adding cellulase and brown sugar, controls
30-40 DEG C of fermentation temperature processed, pH value 5.0-7.0, moisture content 35-60% w/w, Chinese medicine powder obtained by step A is carried out normal
Pressure ferment continues 12-48 hours, adjusts pH value to neutrality, drying obtains Chinese medicine ferment material；
C, ball milling technology for broken wall: small-sized ball mill is selected, and using 0.5-2.5mm microballon to Chinese medicine ferment material obtained by step B
Friction feeding crushing is carried out, products therefrom is the traditional Chinese herbs broken wall material through abundant broken wall；
D, addition obtained by upper step was fully ground gypsum, the alum powder of 300 meshes, obtained datura flower asthma relieving powder broken wall Ultramicro-powder
Agent.
6. the circulation of datura flower asthma relieving powder according to claim 5 crushes biological ferment ball milling broken wall preparation process, feature
Be: in step A, the return fan continues 5-15s after starting every time and is again switched off at interval of 0.5-1.5min intermittently starting；
Iterative cycles；In step A, the mesh screen of 200 mesh is set in the discharge port end of smashing portion.
7. the circulation of datura flower asthma relieving powder according to claim 5 crushes biological ferment ball milling broken wall preparation process, feature
Be: in step A, the blast pressure of the blast pressure pressure fan is higher by 30%；Return fan continues after starting every time
15s is again switched off；Or the blast pressure of the blast pressure pressure fan is higher by 50%；Return fan is held after starting every time
Continuous 5s is again switched off.
8. the circulation of datura flower asthma relieving powder according to claim 5 crushes biological ferment ball milling broken wall preparation process, feature
Be: in step B, stover ferment agent, bacillus subtilis are sufficiently activated in 35 DEG C of brown sugar water first using preceding, so that
Viable bacteria number reaches 10,000,000,000/CFU or more；The weight fraction ratio of bacterium solution, Chinese medicine powder, brown sugar, cellulase after activated
For (35-70): (20-40): (10-20): (0.1-1) w/w.
9. the circulation of datura flower asthma relieving powder according to claim 5 crushes biological ferment ball milling broken wall preparation process, feature
Be: in step B, drying temperature is not higher than 65 DEG C；It blows in drying to accelerate drying rate；In step B, using acetic acid,
Sodium carbonate, sodium bicarbonate system carry out pH adjusting；In step B, normal pressure ferments 20-40 hours.
10. the circulation of datura flower asthma relieving powder according to claim 5 crushes biological ferment ball milling broken wall preparation process, feature
It is: in step C, bead diameter 0.6-1.6mm；Product crosses 300 meshes.
Priority Applications (1)
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101690758A (en) * | 2009-08-07 | 2010-04-07 | 天津生机集团股份有限公司 | Compound datura flower asthma relieving powder for treating respiratory tract infection of pigs and preparation method thereof |
| CN102512538A (en) * | 2011-11-28 | 2012-06-27 | 河南省康星药业有限公司 | Normal-temperature preparation method for ultrafine golden flower asthma-relieving powder and special bilateral airflow sieving machine thereof |
| JP2013116080A (en) * | 2011-12-05 | 2013-06-13 | Sachi Unate | Fluidity lactic acid feed for rumination livestock and manufacturing method of the same |
| RU2012100485A (en) * | 2012-01-10 | 2013-07-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" | METHOD FOR PRODUCING FODDER ADDITIVE WITH ENZYMATIC PROPERTIES FOR BIRD |
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- 2019-04-30 CN CN201910360147.4A patent/CN110051751A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101690758A (en) * | 2009-08-07 | 2010-04-07 | 天津生机集团股份有限公司 | Compound datura flower asthma relieving powder for treating respiratory tract infection of pigs and preparation method thereof |
| CN102512538A (en) * | 2011-11-28 | 2012-06-27 | 河南省康星药业有限公司 | Normal-temperature preparation method for ultrafine golden flower asthma-relieving powder and special bilateral airflow sieving machine thereof |
| JP2013116080A (en) * | 2011-12-05 | 2013-06-13 | Sachi Unate | Fluidity lactic acid feed for rumination livestock and manufacturing method of the same |
| RU2012100485A (en) * | 2012-01-10 | 2013-07-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" | METHOD FOR PRODUCING FODDER ADDITIVE WITH ENZYMATIC PROPERTIES FOR BIRD |
Non-Patent Citations (1)
| Title |
|---|
| 王秀飞等 * |
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Application publication date: 20190726 |