CN110038100A - 一种治疗流行性感冒的膏药及制备方法 - Google Patents

一种治疗流行性感冒的膏药及制备方法 Download PDF

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CN110038100A
CN110038100A CN201910420489.0A CN201910420489A CN110038100A CN 110038100 A CN110038100 A CN 110038100A CN 201910420489 A CN201910420489 A CN 201910420489A CN 110038100 A CN110038100 A CN 110038100A
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石如全
石志颖
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Abstract

本发明公开了一种治疗流行性感冒的膏药,它含有以下药物:紫金牛,牛大力,竹黄,九股牛,黑面神,麻黄,枇杷叶,百部,知母,川贝,贯众,植物油,黄丹。所述的药物具体选取的量:紫金牛290‑310克,牛大力190‑210克,竹黄140‑155克,九股牛95‑108克,黑面神90‑105克,麻黄46‑55克,枇杷叶47‑54克,百部195‑205克,知母144‑208克,川贝142‑157克,贯众44‑53克,植物油5500‑6400克,黄丹2500‑2700克。本发明使用效果好,且为外敷的方式,尤其适用于幼儿。

Description

一种治疗流行性感冒的膏药及制备方法
技术领域
本发明涉及中药,特别是一种治疗流行性感冒的膏药及制备方法。
背景技术
流行性感冒是春秋季较为常见的疾病,发病范围广,易感人群较多,尤其是老人和孩子一旦患病,如不及时治疗;很容易引发更为严重的疾病。现有的中、西药虽有针对儿童使用的药物,但是很多幼儿因为年龄较小,直接口服或饮用药品,较为困难,如果进行静脉注射,儿童多动且敏感,其具体治疗也存在很多不便。
发明内容
本发明的目的是提供一种治疗效果好,且使用方法简便的治疗流行性感冒的膏药。
本发明的技术方案是,一种治疗流行性感冒的膏药,其特征在于:它含有以下药物:紫金牛,牛大力,竹黄,九股牛,黑面神,麻黄,枇杷叶,百部,知母,川贝,贯众,植物油,黄丹。
所述的药物具体选取的量:紫金牛290-310克,牛大力190-210克,竹黄140-155克,九股牛95-108克,黑面神90-105克,麻黄46-55克,枇杷叶47-54克,百部195-205克,知母144-208克,川贝142-157克,贯众44-53克,植物油5500-6400克,黄丹2500-2700克。
本发明的制作工艺是,一种治疗流行性感冒的膏药的制备方法:
1、药物提取:将准备好如各种药品以及植油分别的入锅中浸泡两天两夜,然后用小火加热,用槐木棍不断搅拌,直到药物炸成枯黄色,用铁笊篱捞去药渣;
2、炼油:药油大火加热熟炼,槐木棍不断搅拌,油热冒青烟,然后变浓烟,取油滴入水中成珠不散即可,关火;
3、下具:将油锅离开火,慢慢下丹,匀速顺时针搅拌直至丹下完,但仍搅拌至滴水成珠后,以不粘手,扯出粘丝为好。
4、去火毒:然后将熬成的膏药倒入冷水中冷却,每日换一次冷水,7天后可摊制药膏。
步骤1中的加热温度为240-260度。
所述的第2步中:油温达到310-330度。
本发明使用效果好,且为外敷的方式,尤其适用于幼儿。
具体实施方式
实施例1,
先选取:紫金牛290克,牛大力190克,竹黄155克,九股牛108克,黑面神90克,麻黄46克,枇杷叶47克,百部195克,知母144克,川贝157克,贯众53克,植物油6400克,黄丹2500克。
再进行制备:
1、药物提取:将准备好如各种药品以及植物油分别的入锅中浸泡两天两夜,然后用小火加热,温度到240度,用槐木棍不断搅拌,直到药物炸成枯黄色,用铁笊篱捞去药渣;
2、炼油:药油大火加热熬炼,槐木棍不断搅拌,油热冒青烟,油温达到310度,然后变浓烟,取油滴入水中成珠不散即可,关火;
3、下具:将油锅离开火,慢慢下丹,匀速顺时针搅拌直至丹下完。但仍搅拌至滴水成珠后,以不粘手,扯出粘丝为好。
4、去火毒:然后将熬成的膏药倒入冷水中冷却,每日换一次冷水,7天后可摊制药膏。
实施例2
先选取:紫金牛310克,牛大力200克,竹黄145克,九股牛101克,黑面神105克,麻黄55克,枇杷叶50克,百部205克,知母190克,川贝142克,贯众44克,植物油6000克,黄丹2600克。
再进行制备:
1、药物提取:将准备好如各种药品以及植油分别的入锅中浸泡两天两夜,然后用小火加热,温度到260度,用槐木棍不断搅拌,直到药物炸成枯黄色,用铁笊篱捞去药渣;
2、炼油:药油大火加热熟炼,槐木棍不断搅拌,油热冒青烟,油温达到320度,然后变浓烟,取油滴入水中成珠不散即可,关火;
3、下具:将油锅离开火,慢慢下丹,匀速顺时针搅拌直至丹下完。但仍搅拌至滴水成珠后,以不粘手,扯出粘丝为好。
4、去火毒:然后将熬成的膏药倒入冷水中冷却,每日换一次冷水,7天后可摊制药膏。
实施例3
先选取:紫金牛300克,牛大力210克,竹黄140克,九股牛95克,黑面神100克,麻黄51克,枇杷叶54克,百部200克,知母208克,川贝150克,贯众49克,植物油6400克,黄丹2700克。
再进行制备:
1、药物提取:将准备好如各种药品以及植油分别的入锅中浸泡两天两夜,然后用小火加热,温度到250度,用槐木棍不断搅拌,直到药物炸成枯黄色,用铁笊篱捞去药渣;
2、炼油:药油大火加热熟炼,槐木棍不断搅拌,油热冒青烟,油温达到330度,然后变浓烟,取油滴入水中成珠不散即可,关火;
3、下具:将油锅离开火,慢慢下丹,匀速顺时针搅拌直至丹下完。但仍搅拌至滴水成珠后,以不粘手,扯出粘丝为好。
4、去火毒:然后将熬成的膏药倒入冷水中冷却,每日换一次冷水,7天后可摊制药膏。
本发明使用方法:
1.摊膏:将去火毒后的膏药放入铁锅中溶化,用一支竹筷取3g-4.5g的膏药摊在膏药布上贴于天突穴上,另取6g-9g膏药均分成两贴分别贴于两侧肺俞穴上,每贴膏药两天换一次,
2.禁忌:禁食生冷、油腻、辛辣、海鲜类食物。
3.注意事项:贴后膏药痒即揭下,不痒后再贴,过敏性皮肤或者皮肤有遗烂处禁止贴敷。
上述实施例仅仅是为清楚地说明所作的举例,而并非对实施方式的限定。对于所属领域的普通技术人员来说,在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举,而由此所引伸出的显而易见的变化或变动仍处于本发明创造的保护范围之内。
病例:
1,石某某、女,8个月,封丘具应举镇石楼村人,因流感恢复期来珍,家长诉医院诊断流感,吃药后退烧,现咳嗽较重,痰多,精神欠佳,哭闹不乖,腹胀,贴平衡咳喘贴后,咬嗽次数明显减少、两天后复诊,听诊痰鸣音消失,没有再咳嗽,精神明显好转,之后每次流感都是一次痊愈。
2.王某某,女.两岁半,封丘县应举镇付里庄村人,2018年10月2日,因患流感服药5天,未愈、现有流鼻涕、喷嗽,嗓子红等症状.贴平衡咳喘贴一次,三天后复诊痊愈。
3.杜某某,男. 3岁,封丘县居厢乡人2018年9月27日就珍,患流感一周。吃药输液效累均不佳。就诊时,病人流涕,咳嗽不上,贴平衡于咳喘贴后,3天后基本痊愈.后又巩固复贴一次痊愈。
4.薛某某,男,3岁半,封丘县荆宫乡大娄地村人。2018年10月6日患流感,吃药后发热退至正常,但咳嗽夜不能寐,贴平衡咳喘贴当天夜里咳嗽明显减少,3天后症状消失。
5.吴某某,女,4岁,封丘县陈固乡付固村人。2018年7月,因流感发热咳嗽就诊,吃药即吐,听别人介绍后来贴平衡咳喘贴,贴后夜里咳嗽明里减少,一天后退热,痊愈,家人非常高兴。所以小女孩以后每感冒,发热、咳嗽都主动前来贴敷基上都是一贴痊愈。

Claims (5)

1.一种治疗流行性感冒的膏药,其特征在于:它含有以下药物:紫金牛,牛大力,竹黄,九股牛,黑面神,麻黄,枇杷叶,百部,知母,川贝,贯众,植物油,黄丹。
2.如权利要求1所述的一种治疗流行性感冒的膏药,其特征在于,所述的药物具体选取的量:紫金牛290-310克,牛大力190-210克,竹黄140-155克,九股牛95-108克,黑面神90-105克,麻黄46-55克,枇杷叶47-54克,百部195-205克,知母144-208克,川贝142-157克,贯众44-53克,植物油5500-6400克,黄丹2500-2700克。
3.一种治疗流行性感冒的膏药的制备方法,其特征在于:
(1)、药物提取:将准备好如各种药品以及植油分别的入锅中浸泡两天两夜,然后用小火加热,用槐木棍不断搅拌,直到药物炸成枯黄色,用铁笊篱捞去药渣;
(2)、炼油:药油大火加热熟炼,槐木棍不断搅拌,油热冒青烟,然后变浓烟,取油滴入水中成珠不散即可,关火;
(3)、下具:将油锅离开火,慢慢下丹,匀速顺时针搅拌直至丹下完,但仍搅拌至滴水成珠后,以不粘手,扯出粘丝为好;
(4)、去火毒:然后将熬成的膏药倒入冷水中冷却,每日换一次冷水,7天后可摊制药膏。
4.如权利要求3所述的的一种治疗流行性感冒的膏药的制备方法,其特征在于,步骤1中的加热温度为240-260度。
5.如权利要求3所述的的一种治疗流行性感冒的膏药的制备方法,其特征在于,所述的第2步中:油温达到310-330度。
CN201910420489.0A 2019-05-20 2019-05-20 一种治疗流行性感冒的膏药及制备方法 Pending CN110038100A (zh)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101172144A (zh) * 2006-10-30 2008-05-07 杨文龙 一种润肺止咳祛痰定喘药物及其制备方法
CN102357181A (zh) * 2011-10-25 2012-02-22 陕西步长制药有限公司 一种治疗咳嗽的中药组合物及其制备方法
CN103599440A (zh) * 2013-10-31 2014-02-26 广西健丰药业有限公司 一种含杧果叶的中药组合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101172144A (zh) * 2006-10-30 2008-05-07 杨文龙 一种润肺止咳祛痰定喘药物及其制备方法
CN102357181A (zh) * 2011-10-25 2012-02-22 陕西步长制药有限公司 一种治疗咳嗽的中药组合物及其制备方法
CN103599440A (zh) * 2013-10-31 2014-02-26 广西健丰药业有限公司 一种含杧果叶的中药组合物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
张奇文: "《中国膏敷疗法 第2版》", 31 January 2018, 中国医药科技出版社 *
钟家台: "中医秘方42-咳嗽", 《中医秘方42-咳嗽,HTTP://WWW.360DOC.COM/CONTENT/14/0501/12/3218641_373693697.SHTML》 *
陈企望、赵秀清: "《临床常用中药手册》", 30 October 1994 *

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