CN109939149B - Pharmaceutical composition for preventing alopecia and promoting growth - Google Patents
Pharmaceutical composition for preventing alopecia and promoting growth Download PDFInfo
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Abstract
本发明属于中药技术领域，涉及一种防脱发促生长的药物组合物，包括羌活、藁本、首乌藤、白芍、白芷、葛根、川芎以及侧柏叶，其重量份为羌活15份、藁本15份以及首乌藤20份、白芍12份、白芷12份、葛根12份、川芎12份以及侧柏叶15份，还包括升麻、苍术以及透骨草，其重量份分别为升麻9份、苍术12份以及透骨草6份，还包括炙甘草，其重量份为6份。本发明能有效防止脱发，修复毛囊，促进毛发新生，安全温和，适应各类人群。The invention belongs to the technical field of traditional Chinese medicines, and relates to a medicinal composition for preventing hair loss and promoting growth, comprising Qianghuo, Ligusticum radix, Shouwuteng, Baishao, Angelica, Pueraria, Chuanxiong and Arborvitae, and the parts by weight are 15 parts of Qianghuo, 15 parts of Ligusticum Root, 20 parts of Shouwu Teng, 12 parts of Baishao, 12 parts of Angelica Radix, 12 parts of Pueraria lobata, 12 parts of Chuanxiong and 15 parts of Arborvitae, also including Cimicifuga, Atractylodes Rhizoma and Tokusao, the parts by weight are respectively 9 parts of Cimicifuga, 12 parts of Atractylodes Rhizoma, 6 parts of Tougucao, and 6 parts by weight of Zhigancao. The invention can effectively prevent hair loss, repair hair follicles, promote hair regeneration, is safe and mild, and is suitable for all kinds of people.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, relates to a pharmaceutical composition, and particularly relates to a pharmaceutical composition for preventing alopecia and promoting growth.
Background
Alopecia refers to the phenomenon of hair loss, and generally, hair loss can be divided into two basic types, namely permanent hair loss and temporary hair loss. Permanent alopecia, namely common male baldness, in some European countries, the baldness rate of males is as high as 40%, when the permanent alopecia starts, the head margin of the forehead material is obviously retracted, the head top hair is thin, then the hair gradually develops, and finally, only the back of the head and a circle of thin hair at the two sides of the head are left, and the main reasons are as follows: 1. genetic factors, deficiency or dysregulation of male hormones in the blood circulation; 2. being too obese; 3. permanent hair loss can be caused by scars from a variety of skin diseases or skin injuries, natural hair dysplasia, and severe damage to hair follicles from chemical or physical causes. Temporary hair loss is often caused by diseases that result in high fever, and in addition, temporary hair loss can be caused by exposure to X-rays, ingestion of metals (such as thallium, tin, and arsenic) or drugs, malnutrition, certain inflammatory skin diseases, chronic wasting diseases, and endocrine disorders, among others.
The alopecia can bring great influence to the life of people, firstly, the alopecia seriously affects the image and the beauty, is easy to become old, has influence on job hunting, narrows interpersonal relationship and increases mental stress, so the treatment of the alopecia is very slow. There are two current treatment regimens for male pattern alopecia: the first method is hair transplantation, in which the hair follicle of the scalp in a place where hair still grows is transplanted to a place where hair does not grow, that is, from the back of the head to the front; the second method is topical application, which can effectively prevent alopecia caused by various reasons, and promote hair regeneration of bald or hair-scarce part; however, the existing treatment methods are all targeted and do not treat the root cause.
The traditional Chinese medicine considers that the growth of hair has close relation with the abundance or insufficiency of qi and blood of viscera, meridians and collaterals, and in physiological state, the essence and blood of young and strong people are vigorous, the hair grows and is glossy, and the essence and blood of old and weak people are deficient and the hair is withered and falls off; therefore, in the early stage of alopecia, the traditional Chinese medicine treatment mainly aims at eliminating evil and regulating qi and blood; for long-term alopecia, the treatment should be mainly based on tonifying kidney and nourishing blood, strengthening spleen and replenishing qi, and activating blood and dissolving stasis. In a word, the alopecia is considered to be mainly caused by kidney in the traditional Chinese medicine, if the deficiency of both liver and kidney and qi and blood is insufficient, the whole blood circulation is weak, nutrient substances cannot be conveyed to the top of the head at the highest position of the human body, hair follicles on the head cannot be nourished, and the hair follicles shrink gradually, so that the alopecia is caused. The kidney stores essence, controls reproduction, blooms in hair, and hair is the balance of blood, it is considered that kidney is the congenital origin, and hair is the product of blood. Kidney stores essence, liver stores blood, and essence and blood are transformed into each other, but none of them is sufficient.
Disclosure of Invention
In order to solve the technical problems of the background art, the invention aims to provide the anti-hair-loss growth-promoting pharmaceutical composition which can effectively prevent hair loss, repair hair follicles, promote hair regeneration, is safe and mild and is suitable for various people.
The technical scheme adopted by the invention is as follows:
the pharmaceutical composition for preventing alopecia and promoting growth is characterized in that: the pharmaceutical composition for preventing alopecia and promoting growth comprises, by weight, 5-30 parts of notopterygium root, 5-30 parts of ligusticum, 8-40 parts of vine of multiflower knotweed, 4-25 parts of white peony root, 4-25 parts of angelica dahurica, 4-25 parts of kudzu root, 4-25 parts of ligusticum wallichii and 5-30 parts of cacumen biotae.
The notopterygium root, ligusticum, vine of multiflower knotweed, white peony root, angelica dahurica, kudzu vine root, ligusticum wallichii and biota orientalis leaf are respectively 10-22 parts by weight of notopterygium root, 10-20 parts by weight of ligusticum, 12-30 parts by weight of vine of multiflower knotweed, 8-20 parts by weight of white peony root, 8-20 parts by weight of angelica dahurica, 8-20 parts by weight of kudzu root, 8-20 parts by weight of ligusticum wallichii and 10-20 parts by weight of biota orientalis leaf.
The notopterygium root, ligusticum, caulis polygoni multiflori, white peony root, angelica dahurica, kudzu vine root, rhizoma ligustici wallichii and biota orientalis leaf are respectively 15 parts by weight of notopterygium root, 15 parts by weight of ligusticum, 20 parts by weight of caulis polygoni multiflori, 12 parts by weight of white peony root, 12 parts by weight of angelica dahurica, 12 parts by weight of kudzu vine root, 12 parts by weight of rhizoma ligustici wallichii and 15 parts by weight of biota orientalis leaf.
The pharmaceutical composition for preventing alopecia and promoting growth further comprises 2-20 parts of cimicifugae foetidae, 3-20 parts of rhizoma atractylodis and 1-15 parts of garden balsam stem.
The cimicifuga foetida, the rhizoma atractylodis and the garden balsam stem are respectively 5-15 parts of cimicifuga foetida, 8-15 parts of rhizoma atractylodis and 3-10 parts of garden balsam stem.
The weight parts of the cimicifugae foetidae, the rhizoma atractylodis and the garden balsam stem are respectively 9 parts of cimicifugae foetidae, 12 parts of rhizoma atractylodis and 6 parts of garden balsam stem.
The pharmaceutical composition for preventing alopecia and promoting growth further comprises 1-15 parts by weight of honey-fried licorice root.
The honey-fried licorice root is 3-10 parts by weight.
The weight portion of the honey-fried licorice root is 6 portions.
The application of the pharmaceutical composition for preventing alopecia and promoting hair follicle growth in the preparation of the medicine for preventing alopecia and promoting hair follicle growth.
The invention has the beneficial effects that:
the invention adopts notopterygium root, ligusticum and vine of multiflower knotweed as the monarch drugs, and has the efficacy of removing dampness and nourishing blood; radix paeoniae alba, radix angelicae, radix puerariae, rhizoma ligustici wallichii and cacumen biotae are used as ministers, and the effects of eliminating dampness, dredging orifices, enriching blood and growing hair are achieved; cimicifugae rhizoma, rhizoma Atractylodis and caulis et folium Gaultheriae Yunnanensis have effects of clearing heat and detoxicating, dispelling pathogenic wind and dispelling cold; the honey-fried licorice root is used as a guide, so that the qi and blood can be supplemented, and the hormone balance in the body can be adjusted; the medicines supplement each other and act together from inside to outside, have the effects of removing dampness, tonifying qi and blood, preventing alopecia and growing hair, are suitable for various crowds, and have remarkable alopecia preventing and growing effects.
Detailed Description
The specific embodiments of the present invention will now be described in detail with reference to the examples.
The traditional Chinese medicine plants adopted by the invention have the following effects:
notopterygium root: warm in nature, pungent and bitter in flavor; entering bladder and kidney meridians; has the effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, eliminating dampness, and relieving pain; it can be used for treating wind-cold type common cold, arthralgia due to wind-cold-dampness, neck stiffness, spasm of muscles, soreness of bone joints, edema due to wind-damp, superficial infection, and skin sore.
Ligusticum: warm in nature and pungent in flavor; entering bladder meridian; the effects of expelling wind and cold, removing dampness and relieving pain; it can be used for treating wind-cold exterior syndrome, parietal pain, and rheumatic arthralgia.
Caulis polygoni multiflori: the nature is mild and the taste is sweet; heart and liver meridian entered; has the functions of nourishing blood, tranquilizing, dispelling wind and dredging meridian; mainly treats insomnia and dreaminess, blood deficiency and body pain, and rheumatism and arthralgia; it can be used for treating skin pruritus.
White peony root: slightly cold in nature and bitter in acid; entering liver and spleen meridians; the functions of nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain and calming liver yang; can be used for treating blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm and pain, headache, and vertigo.
Radix angelicae: warm in nature and pungent in flavor; entering stomach, large intestine and lung meridians; has the functions of dispelling wind and eliminating dampness, dredging orifices and relieving pain, and reducing swelling and expelling pus; can be used for treating common cold, headache, supraorbital bone pain, nasal obstruction, nasosinusitis, toothache, leucorrhea, and pyocutaneous disease with swelling and pain.
Kudzu root: sweet and pungent in flavor and cool in nature; meridian tropism entered spleen and stomach meridians; the functions of expelling pathogenic factors from muscles and skin, allaying fever, promoting the production of body fluid, promoting eruption, invigorating yang and relieving diarrhea; can be used for treating fever, headache, stiffness and pain of neck and back, thirst, diabetes, measles without adequate eruption, dysentery, and diarrhea; hypertension neck and neck pain.
Ligusticum wallichii: pungent taste and warm nature; entering liver, gallbladder and pericardium; the efficacy is to activate blood and promote qi circulation, dispel wind and relieve pain; can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.
Cacumen biotae: bitter and astringent taste, cold in nature; it enters lung, liver and spleen meridians; has the effects of cooling blood, stopping bleeding, growing hair and blackening hair; can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, metrostaxis, alopecia due to blood heat, and premature gray hair. Soaking fresh folium Platycladi in 60% ethanol for 7 days, filtering to obtain medicinal liquid, and applying onto hair loss part for 3 times a day, wherein the hair growth is dense and the hair loss is not easy to occur if continuous application is maintained and the medicinal concentration is increased.
Cimicifugae foetidae: pungent, slightly sweet and slightly cold in nature; it enters lung, spleen, stomach and large intestine meridians; has the effects of relieving exterior syndrome, promoting eruption, clearing away heat and toxic materials, and lifting yang qi; can be used for treating headache due to wind-heat evil, toothache, aphtha, sore throat, measles without adequate eruption, and macula due to yang toxin.
Rhizoma atractylodis: pungent and bitter taste, warm nature; spleen, stomach and liver meridians entered; the effects of eliminating dampness, strengthening spleen, dispelling wind and cold and improving eyesight; can be used for treating abdominal distention, diarrhea, edema, tinea pedis, paralysis 36484m, rheumatalgia, common cold due to wind-cold evil, and night blindness.
Garden balsam stem: pungent and bitter taste, warm nature; entering liver and kidney meridians; has the effects of dispelling wind and eliminating dampness, and removing toxic substance and relieving pain; for rheumatic joint pain; it is used externally to treat sore and ulcer with swelling and toxin.
Honey-fried licorice root: sweet in taste and neutral in nature; entering heart, lung, spleen and stomach meridians; has the functions of invigorating spleen and stomach, benefiting qi and recovering pulse; mainly treats weakness of the spleen and the stomach, lassitude and hypodynamia, palpitation and intermittent pulse; licorice contains liquiritigenin, a hormone-like compound, which helps to balance the hormone content in the female. The efficacy of gan-ji-gan-zhi-tang is as tonifying qi and blood and restoring pulse by tonifying deficiency and blood and qi.
Based on the plant effects, the pharmaceutical composition for preventing alopecia and promoting growth comprises, by weight, 5-30 parts of notopterygium root, 5-30 parts of ligusticum, 8-40 parts of vine of multiflower knotweed, 4-25 parts of white peony root, 4-25 parts of angelica dahurica, 4-25 parts of radix puerariae, 4-25 parts of ligusticum wallichii and 5-30 parts of cacumen biotae. The weight parts of notopterygium root, ligusticum, vine of multiflower knotweed, white peony root, angelica root, kudzu vine root, Szechuan lovage rhizome and Chinese arborvitae twig are respectively 10-22 parts of notopterygium root, 10-20 parts of ligusticum, 12-30 parts of vine of multiflower knotweed, 8-20 parts of white peony root, 8-20 parts of angelica root, 8-20 parts of kudzu vine root, 8-20 parts of Szechuan lovage rhizome and 10-20 parts of Chinese arborvitae twig. The weight parts of notopterygium root, ligusticum, vine of multiflower knotweed, white peony root, dahurian angelica root, kudzuvine root, Szechuan lovage rhizome and Chinese arborvitae twig are respectively 15 parts of notopterygium root, 15 parts of ligusticum, 20 parts of vine of multiflower knotweed, 12 parts of white peony root, 12 parts of dahurian angelica root, 12 parts of kudzuvine root, 12 parts of szechuan lovage rhizome and 15 parts of Chinese arborvitae twig.
The pharmaceutical composition for preventing alopecia and promoting growth further comprises 2-20 parts of cimicifugae foetidae, 3-20 parts of rhizoma atractylodis and 1-15 parts of garden balsam stem. The weight parts of the cimicifugae foetidae, the rhizoma atractylodis and the garden balsam stem are respectively 5-15 parts of cimicifugae foetidae, 8-15 parts of rhizoma atractylodis and 3-10 parts of garden balsam stem. The weight parts of the cimicifugae foetidae, the rhizoma atractylodis and the garden balsam stem are respectively 9 parts of the cimicifugae foetidae, 12 parts of the rhizoma atractylodis and 6 parts of the garden balsam stem.
The pharmaceutical composition for preventing alopecia and promoting growth further comprises 1-15 parts by weight of honey-fried licorice root. 3-10 parts of honey-fried licorice root. The weight portion of the honey-fried licorice root is 6 portions.
Application of the pharmaceutical composition for preventing alopecia and promoting hair follicle growth in preparing medicine for preventing alopecia and promoting hair follicle growth is provided.
Formulation examples
According to the efficacy of the Chinese medicinal plants, the following preparation examples with different weight parts can be obtained, and the results are shown in table 1.
TABLE 1 pharmaceutical compositions in different parts by weight
Therapeutic example 1
The patients: male, 20 years old, somewhere in the river; the main complaints are: one year of alopecia, family genetic history, much oil on scalp, pruritus and desquamation; after inspection: the hair on the top of the head is thin, the temples on the two sides move backwards, the hair is greasy, and the dandruff is much, which belongs to male pattern alopecia; randomly selecting the medicinal compositions in the table 1, putting the compositions into a marmite, adding 6 times of water, decocting for one hour, separating medicinal soup from dregs of a decoction, and taking the medicinal soup orally once a day for one month; the patient is found to have no adverse reaction symptom by the double-diagnosis, the degree of hair oil is reduced, dandruff is reduced, the hair loss is less, and a plurality of fine villi grow on the top of the head, the pharmaceutical composition is continuously taken for 1 month, the patient has no dandruff, the oil-out symptom is normal, the hair loss is almost avoided, meanwhile, the top of the head continuously grows the hair, and a plurality of fine villi grow on the temples, so that the hair loss can be effectively prevented, and the hair growth is promoted.
Therapeutic example 2
The patients: lie, male, age 32; the main complaints are: alopecia lasts for three years; after inspection: the hair is greasy, and the hair loss appears at the top of the head, belonging to male pattern hair loss; randomly selecting the medicinal compositions in the table 1, putting the compositions into a marmite, adding 6 times of water, decocting for one hour, separating medicinal soup from dregs of a decoction, and taking the medicinal soup orally twice a day for one month; the patient is found to have no adverse reaction symptom by the double-diagnosis, the degree of hair oil is reduced, a plurality of fine villi grow on the top of the head, the oil-out symptom is obviously improved after the medicine composition is continuously taken for 1 month, and the hair continuously grows on the top of the head, so that the medicine composition can improve the hair oil-out symptom and promote the growth of the hair.
Therapeutic example 3
The patients: anysome, female, 28 years old; the main complaints are: alopecia is half a year; after inspection: the hair is changed into oil on the head, and hair loss causes the hair line to move backwards, belonging to postpartum hair loss; randomly selecting the medicinal compositions in the table 1, putting the compositions into a marmite, adding 6 times of water, decocting for one hour, separating medicinal soup from dregs of a decoction, and taking the medicinal soup orally twice a day for one month; the patient is found to have no adverse effect by the double-diagnosis, the hair oil-out condition is obviously improved, and a plurality of fine villi grow on the temples on both sides of the patient with the alopecia symptom reduced, so that the hair oil-out treatment liquid can improve the hair oil-out, prevent the hair loss and promote the hair growth.
Therapeutic example 4
The patients: some Zhao, male, age 45; the main complaints are: alopecia lasts for five years; after inspection: the head of the hair loss is already bald, and more dandruff belongs to male pattern alopecia; randomly selecting the medicinal compositions in the table 1, putting the compositions into a marmite, adding 6 times of water, decocting for one hour, separating medicinal soup from dregs of a decoction, taking the medicinal soup orally twice a day for one month, and simultaneously smearing the soup on scalp; after the patient is subjected to the double-diagnosis, adverse reaction symptoms do not exist, dandruff does not exist basically, a plurality of fine villi begin to grow on the top of the head, the pharmaceutical composition is continuously taken for 1 month twice a day, the dandruff does not exist on the patient, and new hair is generated on the top of the head, so that the hair regrowth can be promoted.
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| CN114042028B (en) * | 2021-12-15 | 2023-05-05 | 宾阳县祥宝生发养发保健产品有限公司 | Composition for preventing seborrheic alopecia and promoting hair growth and preparation method thereof |
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| 中药联合甘草锌治疗斑秃疗效分析;肖茜等;《中国美容医学》;20171130;第26卷(第11期);第115-116页 * |
| 调营卫益气和血法治疗脂溢性脱发临床研究;吴国强等;《新中医》;20111105;第43卷(第11期);第63-64页 * |
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