CN109913350A - Integrated device for detecting and extracting tumor cells - Google Patents
Integrated device for detecting and extracting tumor cells Download PDFInfo
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- CN109913350A CN109913350A CN201910222237.7A CN201910222237A CN109913350A CN 109913350 A CN109913350 A CN 109913350A CN 201910222237 A CN201910222237 A CN 201910222237A CN 109913350 A CN109913350 A CN 109913350A
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- 210000004881 tumor cell Anatomy 0.000 title claims abstract description 39
- 238000000605 extraction Methods 0.000 claims abstract description 45
- 239000007788 liquid Substances 0.000 claims description 27
- 239000002699 waste material Substances 0.000 claims description 27
- 241000894006 Bacteria Species 0.000 claims description 17
- 239000000284 extract Substances 0.000 claims description 17
- 238000005119 centrifugation Methods 0.000 claims description 9
- 238000007789 sealing Methods 0.000 claims description 8
- 238000003780 insertion Methods 0.000 claims description 6
- 230000037431 insertion Effects 0.000 claims description 6
- 238000009434 installation Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 3
- 230000005611 electricity Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 238000001514 detection method Methods 0.000 abstract description 9
- 210000004027 cell Anatomy 0.000 abstract description 6
- 206010028980 Neoplasm Diseases 0.000 description 9
- 238000010586 diagram Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 4
- 238000001125 extrusion Methods 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 238000012805 post-processing Methods 0.000 description 3
- 239000000356 contaminant Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000505 pernicious effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Centrifugal Separators (AREA)
Abstract
The invention discloses an integrated device for detecting and extracting tumor cells, which comprises a working box, wherein the top end of the working box is provided with an extraction component, one side of the top end of the working box is uniformly embedded with a sterile cylinder, the integrated device is scientific and reasonable in structure and safe and convenient to use, the extraction component is arranged, the extraction and collection cylinder is convenient to fix under the action of a fixing ring and a bump, the extraction and collection cylinder is prevented from shaking during working, the first rubber semi-ring and the second rubber semi-ring are convenient to rotate under the action of the locking ring, the first rubber semi-ring and the second rubber semi-ring are mutually extruded by rotating the locking ring, so that the piston rod is fixed, the phenomenon that after cells are extracted, the extracting solution flows out of the extraction and collection cylinder due to the movement of the piston rod is avoided, the sterile cylinder is arranged, and the sterile storage of a plurality of extraction components is facilitated under, avoid the extraction element to expose and receive the pollution outward, influence cell detection effect, use convenient more reliable.
Description
Technical field
The present invention relates to tumour cell technical field, specially a kind of detect for tumour cell is disguised with the one extracted
It sets.
Background technique
Tumour cell essence is exactly tumour, and tumor tissues are made of essence and interstitial two parts, generally according to the reality of tumour
Matter form identifies the tissue-derived of various tumours, carries out the classification, name and histodiagnosis of tumour, and be divided into according to it
Ripe degree and atypia size determine good pernicious and tumour the grade malignancy of tumour, and tumour cell detection is to pass through TCT
Cytology detector carries out sick cell by its high precision filter membrane core technology and micro computer automatic control system
Detection.
Existing tumour cell extracts and detection device is separated from each other, at high cost and complicated for operation, and common
Tumour cell extraction element structure is simple, is drawn by syringe, is easy to be polluted by outside environment, and operating process
In be easy push syringe so that extracting solution leak, and extracting solution inside impurity it is more, increase the difficulty of post-processing, institute
It is solved the above problems with being badly in need of a kind of detect for tumour cell with the integrated apparatus of extraction.
Summary of the invention
The present invention provides a kind of integrated apparatus detected for tumour cell with extraction, can effectively solve above-mentioned background
It is proposed that existing tumour cell extracts and detection device is separated from each other in technology, it is at high cost and complicated for operation and common
Tumour cell extraction element structure it is simple, drawn by syringe, be easy to be polluted by outside environment, and operate
It is easy to push syringe in journey, so that extracting solution leaks, and impurity is more inside extracting solution, increases the difficulty of post-processing
Problem.
To achieve the above object, the invention provides the following technical scheme: a kind of one detected for tumour cell with extraction
Body makeup is set, including work box, tumour cell sensing chamber and pallet, the work box side are equipped with tumour cell sensing chamber,
Tumour cell sensing chamber bottom end is equipped with pallet, and the work box top is equipped with extraction assembly, and the extraction assembly includes
It extracts surge drum, extract needle, fixed ring, convex block, retaining ring, the first rubber semi-ring, piston rod and the second rubber semi-ring；
The work box top is uniformly provided with extraction surge drum, is inserted into installation at the extraction surge drum bottom dead center position
There is extraction needle, the bottom end edge is socketed with fixed ring, is uniformly equipped with convex block, the surge drum top on the outside of the fixed ring
It is socketed with retaining ring, the retaining ring interior side splicing has the first rubber semi-ring, and insertion is equipped with work inside the surge drum
Stopper rod, the piston rod side, which is glued, the second rubber semi-ring.
Preferably, the retaining ring annular diameters are greater than the diameter of piston rod.
Preferably, work box top side, which is uniformly embedded into, is equipped with no bacterium cylinder, pacifies at the no bacterium cylinder top end opening
Equipped with sealing ring.
Preferably, work box top side edge offers waste collection hole, and waste collection hole bottom end is equipped with
Waste collection room, the waste collection chamber interior are placed with collection box.
Preferably, work box top side, which is uniformly equipped with, blocks component, and the component that blocks includes loose slot, pushes away
Block, connecting rod, shutter, arc groove and rubber pad；
Work box top side is uniformly provided with loose slot, and the loose slot, which is internally embedded, is equipped with pushing block, described
Pushing block bottom end is connected with connecting rod, and described connecting rod one end is connected with shutter, and the shutter side offers arc groove, institute
Stating installation splicing inside arc groove has rubber pad.
Preferably, the radius greater than fixed ring of the arc groove.
Preferably, drain component is installed at the work box top dead center position, the drain component include inlet tube,
Groove, drain expansion screw pipe, screw thread adjust ring, first sleeve and bearing；
Insertion is equipped with inlet tube at the work box top dead center position, and inside is uniform at the inlet tube top end opening
Open up fluted, the inlet tube bottom end is connected with drain expansion screw pipe, is socketed with spiral shell on the outside of the drain expansion screw pipe
Line adjusts ring, and the drain expansion screw tube bottom end is connected by bearing with first sleeve.
Preferably, drain component bottom end is equipped with centrifugation tube assembly, and the centrifugation tube assembly includes centrifuge tube, first
Connector, connecting hole, the second connector, liquid outlet and sealing-plug；
The first sleeve bottom end is equipped with centrifuge tube, and the centrifuge tube top passes through the first connector and first sleeve phase
Even, the centrifuge tube bottom end is equipped with the second connector, offers liquid outlet at the top and bottom of the centrifuge tube side, described
Sealing-plug is installed inside liquid outlet.
Preferably, the component of a kind of rubber material of first connector and the second connector, first connector
It is truncated cone-shaped with the shape of the second connector, the height of the height of first connector less than the second connector.
Preferably, the centrifuge tube bottom end is equipped with the second casing, and second casing shoe is connected with rotating disk, described
Rotating disk bottom end is connected with the output shaft of motor, and the input terminal of the motor and the output end of alternating current are electrically connected.
Compared with prior art, beneficial effects of the present invention: structure of the invention is scientific and reasonable, safe and convenient to use:
1, be provided with extraction assembly, by the effect of fixed ring and convex block, convenient for will extract surge drum and sealing ring or
Inlet tube be connected, thus by extract surge drum be fixed, avoid in work extract surge drum shake, by retaining ring,
The effect of first rubber semi-ring, piston rod and the second rubber semi-ring makes the first rubber semi-ring and second convenient for rotation retaining ring
Rubber semi-ring mutual extrusion, to piston rod is fixed, after avoiding cell extraction, since piston rod movement leads to extracting solution
From outflow inside surge drum is extracted, use is more convenient reliable.
2, it is provided with no bacterium cylinder, by the effect of no bacterium cylinder and sealing ring, convenient for multiple extraction assemblies are carried out sterile storage
It deposits, avoids extraction assembly from being exposed to and be contaminated outside, influence cell detection effect, while convenient for replacing extraction group according to demand
Part avoids waste liquid by the effect in waste collection hole, waste collection room and collection box convenient for the waste liquid generated when collection work
Leakage leads to environmental pollution, and use is safer.
3, be provided with and block component, by the effect of loose slot, pushing block, connecting rod and shutter, convenient for will without bacterium cylinder and
Waste collection hole is blocked, and is avoided introduced contaminants from entering inside no bacterium cylinder and waste collection hole, is passed through arc groove and rubber pad
Effect while increasing its friction between fixed ring using rubber pad convenient for squeezing the fixed ring for extracting surge drum bottom end
Power, and avoid that fixed ring is caused to wear, to be reinforced to surge drum is extracted, extracts and collect in avoiding device moving process
Cylinder is detached from no bacterium cylinder and waste collection hole, and use is more stable.
4, it is provided with drain component, by the effect of inlet tube, groove and drain expansion screw pipe, is convenient for and extracts collection
Cylinder is assembled, to guide the liquid acquired inside surge drum is extracted, is adjusted by the thread ring and first sleeve
Effect, convenient for adjusting the length of drain expansion screw pipe, so that first sleeve is installed according to demand with centrifuge tube, thus
Centrifuge tube top is fixed, by the effect of bearing, convenient for so that centrifuge tube does not have an impact first sleeve when rotating,
It is easy to operate, it is easy to use.
5, it is provided with centrifugation tube assembly, by the effect of centrifuge tube, convenient for collecting the extraction of drain expansion screw pipe conveying
Liquid, by motor, the effect of rotating disk and the second casing, convenient for centrifuge tube bottom end is fixed, to be carried out to centrifuge tube
Centrifugal work will be layered the extracting solution inside centrifuge tube by centrifugal force, be connected by the first connector and second
The effect of head keeps its centrifugal work more stable so that centrifuge tube and first sleeve and the second casing connection is even closer, logical
The effect of liquid outlet is crossed, convenient for according to demand separately pouring out the liquid of the liquid on centrifuge tube top and bottom end, to mention
The purity for taking liquid internal tumours cell improves the precision of measurement.
Detailed description of the invention
Attached drawing is used to provide further understanding of the present invention, and constitutes part of specification, with reality of the invention
It applies example to be used to explain the present invention together, not be construed as limiting the invention.
In the accompanying drawings:
Fig. 1 is structural schematic diagram of the invention；
Fig. 2 is the structural schematic diagram of work box of the present invention；
Fig. 3 is the structural schematic diagram of extraction assembly of the present invention；
Fig. 4 is the structural schematic diagram that the present invention blocks component；
Fig. 5 is the structural schematic diagram of drain component of the present invention；
Fig. 6 is the structural schematic diagram of present invention centrifugation tube assembly；
Figure label: 1, work box；2, tumour cell sensing chamber；3, pallet；
4, extraction assembly；401, surge drum is extracted；402, needle is extracted；4003, fixed ring；404, convex block；405, retaining ring；
406, the first rubber semi-ring；407, piston rod；408, the second rubber semi-ring；
5, without bacterium cylinder；6, sealing ring；7, waste collection hole；8, waste collection room；9, collection box；
10, component is blocked；1001, loose slot；1002, pushing block；1003, connecting rod；1004, shutter；1005, arc
Slot；1006, rubber pad；
11, drain component；1101, inlet tube；1102, groove；1103, drain expansion screw pipe；1104, screw thread is adjusted
Ring；1105, first sleeve；1106, bearing；
12, it is centrifuged tube assembly；1201, centrifuge tube；1202, the first connector；1203, connecting hole；1204, the second connection
Head；1205, liquid outlet；1206, sealing-plug；
13, motor；14, rotating disk；15, the second casing.
Specific embodiment
Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings, it should be understood that preferred reality described herein
Apply example only for the purpose of illustrating and explaining the present invention and is not intended to limit the present invention.
Embodiment: as shown in figures 1 to 6, the present invention provides a kind of technical solution, and one kind is detected and extracted for tumour cell
Integrated apparatus, including work box 1, tumour cell sensing chamber 2 and pallet 3,1 side of work box is equipped with tumour cell detection
Room 2,2 bottom end of tumour cell sensing chamber are equipped with pallet 3, and 1 top of work box is equipped with extraction assembly 4, and extraction assembly 4 includes extracting
Surge drum 401 extracts needle 402, fixed ring 403, convex block 404, retaining ring 405, the first rubber semi-ring 406, piston rod 407 and the
Two rubber semi-rings 408；
1 top of work box, which is uniformly provided with, extracts surge drum 401, extracts and is inserted into installation at 401 bottom dead center position of surge drum
Have and extract needle 402, bottom end edge is socketed with fixed ring 403, and 403 outside of fixed ring is uniformly equipped with convex block 404, surge drum 401
Top is socketed with retaining ring 405, and the splicing of 405 interior side of retaining ring has the first rubber semi-ring 406, is inserted into inside surge drum 401
Piston rod 407 is installed, 407 side of piston rod, which is glued, the second rubber semi-ring 408, for the ease of coming when the work of piston rod 407
Return is dynamic, and 405 annular diameters of retaining ring are greater than the diameter of piston rod 407, is contaminated in order to avoid extracting surge drum 401, work
Make 1 top side of case and be uniformly embedded into that no bacterium cylinder 5 is installed, sealing ring 6 is installed at no 5 top end opening of bacterium cylinder, for the ease of receiving
Collect waste liquid, avoids waste liquid leakage from polluting, 1 top side edge of work box offers waste collection hole 7, waste collection hole 7
Bottom end is equipped with waste collection room 8, is placed with collection box 9 inside waste collection room 8.
In order to avoid impurity enters inside no bacterium cylinder 5 and waste collection hole 7,1 top side of work box is uniformly equipped with screening
Component 10 is kept off, blocking component 10 includes loose slot 1001, pushing block 1002, connecting rod 1003, shutter 1004,1005 and of arc groove
Rubber pad 1006,1 top side of work box are uniformly provided with loose slot 1001, and loose slot 1001, which is internally embedded, is equipped with pushing block
1002,1002 bottom end of pushing block is connected with connecting rod 1003, and 1003 one end of connecting rod is connected with shutter 1004, shutter 1,004 1
Side offers arc groove 1005, and installation, which is glued, inside arc groove 1005 rubber pad 1006, in order to squeeze fixed ring 403, to solid
Determine ring 403 to be fixed, the radius greater than fixed ring 403 of arc groove 1005.
Drain component 11 is installed, drain component 11 includes inlet tube 1101, groove at 1 top dead center position of work box
1102, drain expansion screw pipe 1103, screw thread adjust ring 1104, first sleeve 1105 and bearing 1106,1 top center of work box
Insertion is equipped with inlet tube 1101 at position, at 1101 top end opening of inlet tube inside be uniformly provided with groove 1102, inlet tube
1101 bottom ends are connected with drain expansion screw pipe 1103, and screw thread is socketed on the outside of drain expansion screw pipe 1103 and adjusts ring 1104,
1103 bottom end of drain expansion screw pipe is connected by bearing 1106 with first sleeve 1105, is realized and is worked the water conservancy diversion of extracting solution.
For the ease of collecting extracting solution, 11 bottom end of drain component is equipped with centrifugation tube assembly 12, and centrifugation tube assembly 12 includes
Centrifuge tube 1201, the first connector 1202, connecting hole 1203, the second connector 1204, liquid outlet 1205 and sealing-plug 1206, the
1105 bottom end of sleeve is equipped with centrifuge tube 1201, and 1201 top of centrifuge tube passes through the first connector 1202 and first sleeve 1105
It is connected, 1201 bottom end of centrifuge tube is equipped with the second connector 1204, offers out liquid at the top and bottom of 1201 side of centrifuge tube
Mouthfuls 1205, sealing-plug 1206 is installed inside liquid outlet 1205, in order to improve the stability of centrifuge tube 1201, the first connector
1202 and second connector 1204 a kind of rubber material component, the shape of the first connector 1202 and the second connector 1204
For truncated cone-shaped, the height of the first connector 1202 less than the second connector 1204 height, for the ease of to extracting solution carry out from
Heart purification, 1201 bottom end of centrifuge tube are equipped with the second casing 15, and 15 bottom end of the second casing is connected with rotating disk 14,14 bottom of rotating disk
End is connected with the output shaft of motor 13, and wherein the signal of motor 13 is 57BLF-0730NBB, the input terminal of motor 13 and alternating current
Output end is electrically connected.
The working principle of the invention and process for using: when the device is made operational, the extraction of multiple disinfections is collected first
Cylinder 401 is inserted into inside without bacterium cylinder 5, is connect by sealing ring 6 with fixed ring 403, thus be fixed surge drum 401 is extracted,
Convex block 404 is pushed simultaneously, then convex block 404 drives connecting rod 1003 mobile, then drives shutter by connecting rod 1003
1004 is mobile, is then contacted by the arc groove 1005 of 1004 side of shutter with fixed ring 403, thus to fixed ring 403 into
Row is reinforced, so that extraction surge drum 401 is more stable, device is then moved to working region, thus without that will mention inside bacterium cylinder 5
It takes surge drum 401 to extract, pushes pushing block 1002, pushing block 1002 drives connecting rod 1003 to be moved to no 5 opening of bacterium cylinder, connects
Will be blocked without 5 opening of bacterium cylinder by shutter 1004, avoid introduced contaminants enter wherein, will extract surge drum 401
The insertion of extraction needle 402 of bottom end contains organization internal to be detected, piston rod 407 is then pulled, thus by organization internal to be detected
Liquid drawn, rotation lock ring 405, so that the first rubber semi-ring 406 and piston rod 407 1 inside retaining ring 405
408 mutual extrusion of the second rubber semi-ring of side, passes through the elasticity and friction of the first rubber semi-ring 406 and the second rubber semi-ring 408
Effect avoids piston rod 407 is mobile from causing to extract the leakage of surge drum 401 so that piston rod 407 is fixed；
Then the extraction surge drum 401 with extracting solution is placed into 1101 top of inlet tube, will then extracts surge drum
The fixed ring 403 of 401 bottom ends is inserted into inside inlet tube 1101, is connected by convex block 404 with groove 1102, to collect extracting
Cylinder 401 is fixed, and rotates backward retaining ring 405, so that the first rubber semi-ring 406 is staggered with the second rubber semi-ring 408, thus
The limitation to piston rod 407 is released, then extrusion piston bar 407, so that the extracting solution extracted inside surge drum 401 enters drain
Inside expansion screw pipe 1103, then extracting solution enters the centrifuge tube 1201 of its bottom end connection by drain expansion screw pipe 1103
Then inside starts motor 13, drive rotating disk 14 to rotate by motor 13, and rotating disk 14 drives the rotation of the second casing 15, the
Two casings 15 drive its top connection centrifuge tube 1201 rotated, thus to the extracting solution inside centrifuge tube 1201 carry out from
Heart Purification, by the effect of bearing 1106, so that centrifuge tube 1201 does not have an impact first sleeve 1105 when rotating, by
It is rotary table in the shape of the first connector 1202 and the second connector 1204, and there is elasticity, so that centrifuge tube 1201 is fixed
It is more stable, while the height of the second connector 1204 is greater than the first connector 1202, so that when centrifuge tube 1201 rotates
It is more stable, after the completion of centrifugation, motor 13 is closed, screw thread is then rotated and adjusts ring 1104, by threaded function drain is stretched
Compression screw arbor pipe 1103 moves up, to drive first sleeve 1105 to move up, so that first sleeve 1105 is connect with first
First 1202 separation, then holds centrifuge tube 1201 and takes out centrifuge tube 1201, then successively open centrifuge tube about 1,201 two
The sealing-plug 1206 of liquid outlet 1205 separately pours out the liquid of the liquid of 1201 inner tip of centrifuge tube and bottom end, then will
Waste liquid pours into inside waste collection hole 7, is collected by the collection box 9 inside waste collection room 8, is convenient for post-processing, so
Liquid to be detected is put into 3 upper end of pallet afterwards, and pallet 3 is put into inside tumour cell sensing chamber 2, passes through tumour cell sensing chamber
TCT cytology detector in 2 captures the tumour cell in detection liquid, easy to operate, and detection tumour cell is extracted in integration,
It is safe and reliable.
Finally, it should be noted that being not intended to restrict the invention the foregoing is merely preferred embodiment of the invention, to the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, for those skilled in the art, still can be with
It modifies the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features.It is all
Within the spirit and principles in the present invention, any modification, equivalent replacement, improvement and so on should be included in guarantor of the invention
Within the scope of shield.
Claims (10)
1. a kind of integrated apparatus detected for tumour cell with extraction, including work box (1), tumour cell sensing chamber (2)
With pallet (3), work box (1) side is equipped with tumour cell sensing chamber (2), tumour cell sensing chamber (2) bottom end
Pallet (3) are installed, it is characterised in that: work box (1) top is equipped with extraction assembly (4)；
The extraction assembly (4) includes extracting surge drum (401), extracting needle (402), fixed ring (403), convex block (404), locking
Ring (405), the first rubber semi-ring (406), piston rod (407) and the second rubber semi-ring (408)；
Work box (1) top, which is uniformly provided with, extracts surge drum (401), extraction surge drum (401) bottom dead center position
Place's insertion, which is equipped with, extracts needle (402), and the bottom end edge is socketed with fixed ring (403), on the outside of the fixed ring (403) uniformly
It is equipped with convex block (404), surge drum (401) top is socketed with retaining ring (405), retaining ring (405) interior side
Splicing has the first rubber semi-ring (406), and insertion is equipped with piston rod (407), the piston rod inside the surge drum (401)
(407) side, which is glued, the second rubber semi-ring (408).
2. a kind of integrated apparatus detected for tumour cell with extraction according to claim 1, it is characterised in that: institute
State the diameter that retaining ring (405) annular diameters are greater than piston rod (407).
3. a kind of integrated apparatus detected for tumour cell with extraction according to claim 1, it is characterised in that: institute
It states work box (1) top side and is uniformly embedded into and be equipped with no bacterium cylinder (5), sealing is installed at no bacterium cylinder (5) top end opening
Ring (6).
4. a kind of integrated apparatus detected for tumour cell with extraction according to claim 1, it is characterised in that: institute
It states work box (1) top side edge to offer waste collection hole (7), waste collection hole (7) bottom end is equipped with waste collection
Room (8), the waste collection room (8) is internal to be placed with collection box (9).
5. a kind of integrated apparatus detected for tumour cell with extraction according to claim 1, it is characterised in that: institute
It states work box (1) top side and is uniformly equipped with and block component (10)；
The component (10) that blocks includes loose slot (1001), pushing block (1002), connecting rod (1003), shutter (1004), arc
Shape slot (1005) and rubber pad (1006)；
Work box (1) the top side is uniformly provided with loose slot (1001), and the loose slot (1001) is internally embedded installation
Have pushing block (1002), pushing block (1002) bottom end is connected with connecting rod (1003), and described connecting rod (1003) one end is connected with
Shutter (1004), shutter (1004) side offer arc groove (1005), installation inside the arc groove (1005)
Splicing has rubber pad (1006).
6. a kind of integrated apparatus detected for tumour cell with extraction according to claim 5, it is characterised in that: institute
State the radius greater than fixed ring (403) of arc groove (1005).
7. a kind of integrated apparatus detected for tumour cell with extraction according to claim 1, it is characterised in that: institute
It states and drain component (11) is installed at work box (1) top dead center position；
The drain component (11) includes inlet tube (1101), groove (1102), drain expansion screw pipe (1103), screw thread adjusting
Ring (1104), first sleeve (1105) and bearing (1106)；
It is embedded in and is equipped with inlet tube (1101) at work box (1) top dead center position, inlet tube (1101) top is opened
Internal at mouthful to be uniformly provided with groove (1102), inlet tube (1101) bottom end is connected with drain expansion screw pipe (1103),
It is socketed with screw thread on the outside of the drain expansion screw pipe (1103) and adjusts ring (1104), drain expansion screw pipe (1103) bottom
End is connected by bearing (1106) with first sleeve (1105).
8. a kind of integrated apparatus detected for tumour cell with extraction according to claim 7, it is characterised in that: institute
It states drain component (11) bottom end and centrifugation tube assembly (12) is installed；
The centrifugation tube assembly (12) includes centrifuge tube (1201), the first connector (1202), connecting hole (1203), the second connection
Head (1204), liquid outlet (1205) and sealing-plug (1206)；
First sleeve (1105) bottom end is equipped with centrifuge tube (1201), and centrifuge tube (1201) top passes through the first connection
Head (1202) is connected with first sleeve (1105), and centrifuge tube (1201) bottom end is equipped with the second connector (1204), described
It is offered liquid outlet (1205) at the top and bottom of centrifuge tube (1201) side, sealing is installed inside the liquid outlet (1205)
It fills in (1206).
9. a kind of integrated apparatus detected for tumour cell with extraction according to claim 8, it is characterised in that: institute
State a kind of component of rubber material of the first connector (1202) and the second connector (1204), first connector (1202)
Shape with the second connector (1204) is truncated cone-shaped, and the height of first connector (1202) is less than the second connector
(1204) height.
10. a kind of integrated apparatus detected for tumour cell with extraction according to claim 8, it is characterised in that:
Centrifuge tube (1201) bottom end is equipped with the second casing (15), and the second casing (15) bottom end is connected with rotating disk (14),
Rotating disk (14) bottom end is connected with the output shaft of motor (13), the input terminal of the motor (13) and the output end electricity of alternating current
Property connection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910222237.7A CN109913350B (en) | 2019-03-22 | 2019-03-22 | Integrated device for detecting and extracting tumor cells |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910222237.7A CN109913350B (en) | 2019-03-22 | 2019-03-22 | Integrated device for detecting and extracting tumor cells |
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| Publication Number | Publication Date |
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| CN109913350A true CN109913350A (en) | 2019-06-21 |
| CN109913350B CN109913350B (en) | 2022-05-13 |
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| CN201910222237.7A Expired - Fee Related CN109913350B (en) | 2019-03-22 | 2019-03-22 | Integrated device for detecting and extracting tumor cells |
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| CN109401952A (en) * | 2018-11-15 | 2019-03-01 | 中国科学院深圳先进技术研究院 | A kind of identification of cumulus cell and sorting unit |
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2019
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| US20050176138A1 (en) * | 2004-02-09 | 2005-08-11 | Takahiro Nishimoto | Apparatus for cell culture |
| WO2006104333A1 (en) * | 2005-03-28 | 2006-10-05 | Medimex Co., Ltd | Tumor screening system, collection vial for liquid based cytology, brush for liquid based cytology of cervix carcinoma and supporting solution for cytological diagnosis |
| US20180221550A1 (en) * | 2011-07-08 | 2018-08-09 | Jointechlabs, Inc. | System and methods for preparation of adipose-derived stem cells |
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| CN207271281U (en) * | 2017-08-15 | 2018-04-27 | 中国人民解放军第二军医大学第二附属医院 | A kind of sterile centrifugation tube suit |
| CN107928714A (en) * | 2017-12-29 | 2018-04-20 | 南通霆川电子科技有限公司 | A kind of tumor sampling device |
| CN109401952A (en) * | 2018-11-15 | 2019-03-01 | 中国科学院深圳先进技术研究院 | A kind of identification of cumulus cell and sorting unit |
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| CN109913350B (en) | 2022-05-13 |
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