CN109909217B - Magnetic cleaning and separating device of immunoassay analyzer - Google Patents

Magnetic cleaning and separating device of immunoassay analyzer Download PDF

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Publication number
CN109909217B
CN109909217B CN201910238859.9A CN201910238859A CN109909217B CN 109909217 B CN109909217 B CN 109909217B CN 201910238859 A CN201910238859 A CN 201910238859A CN 109909217 B CN109909217 B CN 109909217B
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China
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reaction cup
cleaning
magnet
magnetic
magnets
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CN201910238859.9A
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CN109909217A (en
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吴国银
郭金龙
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Suzhou Hybiome Biomedical Engineering Co Ltd
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Suzhou Hybiome Biomedical Engineering Co Ltd
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Priority to CN201910238859.9A priority Critical patent/CN109909217B/en
Publication of CN109909217A publication Critical patent/CN109909217A/en
Priority to PCT/CN2019/111366 priority patent/WO2020192091A1/en
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04Cleaning involving contact with liquid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04Cleaning involving contact with liquid
    • B08B3/08Cleaning involving contact with liquid the liquid having chemical or dissolving effect
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor

Abstract

The application relates to a magnetic cleaning and separating device of an immunoassay analyzer, which comprises a reaction cup conveying assembly, a cleaning needle assembly, a magnet assembly and a plurality of cleaning positions; the magnet assembly comprises two oppositely arranged magnet pairs arranged on two sides of the reaction cup running path and a single magnet arranged on one side of the reaction cup running path, the magnet pairs correspond to the cleaning positions, the single magnet is positioned between the cleaning positions or before the first cleaning position in the direction of the reaction cup running path, at least one magnet is arranged on each side of the reaction cup running path between the cleaning positions or before the first cleaning position in the direction of the reaction cup running path, the magnets are alternately arranged on two sides of the reaction cup running path and the magnetic pole directions of the two adjacent magnets are opposite. The magnetic cleaning and separating device has extremely short magnetic separation time, achieves the aim of fully cleaning magnetic beads, and can effectively avoid the cleaning needle from absorbing the magnetic beads.

Description

Magnetic cleaning and separating device of immunoassay analyzer
Technical Field
The application belongs to the technical field of medical equipment, and particularly relates to a magnetic cleaning and separating device of an immunoassay analyzer.
Background
In a full-automatic immunoassay system, effective separation of immune complexes is a key link of immunoassay, and the separation effect directly influences the immunoassay result. At present, in an immunoassay analyzer using magnetic beads as reaction carriers, a magnetic separation method is mainly used for separating immune complexes, wherein the magnetic separation method is to utilize the fact that the immune magnetic beads have easy magnetization capability and specific binding capability at the same time to perform specific binding with a target substance, then retain reactants (immune complexes) bound with the magnetic beads by means of an external magnetic field, and separate redundant reactants and reagents. The time of the whole magnetic separation process of the magnetic separation method can be very short, but the washing effect of the existing magnetic cleaning separation device of the immunoassay analyzer on immune complexes is not good enough.
For example, patent No. CN109433686A discloses a magnetic bead washing device and a full-automatic chemiluminescence immunoassay analyzer, the magnetic bead washing device includes a reaction cup conveying assembly, a washing needle assembly, a magnet assembly and at least two washing positions, the magnet assembly includes a magnet corresponding to each washing position, the magnet can adsorb magnetic beads in the reaction cup to the cup wall of the reaction cup, and the magnets corresponding to any two adjacent washing positions are located on both sides of the reaction cup conveying path, the magnetic bead washing device can make the magnetic beads move from one wall surface of the reaction cup to the wall surface opposite to the wall surface when the reaction cup switches the washing positions, so as to wash the magnetic beads, but the time for moving the magnetic beads from one wall surface of the reaction cup to the wall surface opposite to the wall surface is long, the working efficiency is greatly influenced, if the magnetic beads are not completely adsorbed to the wall surface of the reaction cup, when the washing liquid is adsorbed by the washing needle, the washing needle can easily suck the magnetic beads in the reaction cup.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: the magnetic cleaning and separating device of the immunoassay analyzer is provided for solving the defects that the magnetic bead cleaning efficiency of the existing magnetic cleaning and separating device is low and the cleaning needle is easy to suck the magnetic bead in the reaction cup.
The technical scheme adopted by the invention for solving the technical problems is as follows:
a magnetic cleaning and separating device of an immunoassay analyzer comprises a reaction cup conveying assembly, a cleaning needle assembly, a magnet assembly and a plurality of cleaning positions;
the reaction cup conveying assembly is used for conveying the reaction cups to different cleaning positions;
the cleaning needle assembly is used for injecting cleaning liquid into the reaction cup in the cleaning position and sucking the cleaning liquid from the reaction cup;
the magnet assembly comprises two oppositely arranged magnet pairs arranged on two sides of the reaction cup running path and a single magnet arranged on one side of the reaction cup running path, the magnet pairs correspond to the cleaning positions, the single magnet is positioned between the cleaning positions or before the first cleaning position in the reaction cup running path direction, at least one magnet is arranged on each side of the reaction cup running path between two adjacent cleaning positions or before the first cleaning position in the reaction cup running path direction, and the magnets are alternately arranged on two sides of the reaction cup running path or in the magnet before the first cleaning position in the reaction cup running path direction, and the magnetic pole directions of the two adjacent magnets are opposite.
Preferably, the magnet is a square magnet, and the magnetic pole direction of the magnet is perpendicular to the running path of the reaction cup or the tangent of the running path.
Preferably, when the minimum distance between two adjacent magnets on the same side of the reaction cup running path is less than 15mm, the polarities of the two adjacent magnets on the side close to the reaction cup running path are the same.
Preferably, the single magnet closest to the last cleaning position in the direction of the reaction cup running path is 1-3mm higher than the magnet corresponding to the last cleaning position on the same side of the reaction cup running path adjacent to the single magnet, and the height of the single magnet is 3-5mm lower than that of other magnets.
Preferably, the minimum distance between two magnets of said pair is 6-10 mm.
Preferably, the reaction cup conveying assembly comprises a fixed part and a movable part, wherein a reaction cup running groove is arranged in the fixed part, a containing part for containing the reaction cup is arranged on the movable part, and the movable part can drive the reaction cup to move in the reaction cup running groove.
Preferably, the fixed part and the movable part are respectively a cylinder and a disc rotatably arranged in the cylinder, a circular reaction cup running groove is arranged in the cylinder, and a circle of reaction cup accommodating holes are arranged on the disc in an equal diameter mode.
Preferably, wash the position and have threely, wash position and third washing position for first washing position, second along the reaction cup direction of transportation in proper order, every magnet group that washs the preceding setting in position is two magnets, and the magnet that is close to reaction cup moving slot one side of reaction cup moving slot centre of a circle arranges and the magnet polarity is in proper order being close to reaction cup moving slot one side: s, S, N, N, S, S, the arrangement of the magnets on one side of the reaction cup running groove far away from the circle center of the reaction cup running groove at the magnets on one side close to the reaction cup running groove and the polarities of the magnets are as follows: n, N, S, S, N, N.
Preferably, the height of the other magnets is 8-12mm, and the magnetic induction intensity of the other magnets close to the center point of the end surface of one side of the reaction cup running path is at least 620 mT.
Preferably, the magnet is a permanent magnet, preferably a neodymium iron boron magnet, a samarium cobalt magnet, or an alnico magnet.
The invention also provides an immunoassay analyzer which comprises the immunoassay analyzer magnetic cleaning and separating device.
The invention has the beneficial effects that:
(1) the invention provides a magnetic cleaning and separating device of an immunoassay analyzer, which is characterized in that magnet pairs positioned at two sides of a reaction cup running path are arranged at cleaning positions, and a plurality of magnets positioned at one side of the reaction cup running path are arranged between two adjacent cleaning positions or in front of a first cleaning position in the reaction cup running path direction, so that magnetic beads in a reaction cup are rotated under the action of a magnet group in front of the cleaning positions, magnetic bead clusters are scattered, uncombined substances wrapped in the combined substances are released when the magnetic beads are cleaned, a part of reactants combined with the magnetic beads are well reserved, the purpose of fully cleaning the magnetic beads is achieved, the magnetic beads are quickly attracted to two side walls of the reaction cup under the action of high magnetic induction intensity of the magnet pairs corresponding to the cleaning positions, and the cleaning needles can avoid attracting the magnetic beads in the reaction cup to the cleaning needles when cleaning liquid is sucked in a short time, the time of the whole magnetic separation process can be ensured to be as short as possible, and finally, the magnetic beads in the reaction cup can be ensured to fully react with the substrate after the reaction cup enters the measuring chamber, and the substrate solution is saved.
(2) The magnetic cleaning and separating device of the immunoassay analyzer adopts the square magnet, and the magnetic pole direction of the magnet is vertical to the operation path of the reaction cup or the tangent line of the operation path, the design can lead the magnetic beads in the reaction cup to be quickly attracted to the side wall of the reaction cup, the washing effect of the magnetic beads is enhanced, and the cleaning needle can suck the cleaning solution in a shorter time without sucking the magnetic beads in the reaction cup into the cleaning needle, further, when the minimum distance between two adjacent magnets on the same side of the reaction cup running path is less than 15mm, the polarities of the two adjacent magnets close to one side of the reaction cup running path are the same, the design can avoid that the distance between the two adjacent magnets on the same side of the reaction cup running path is too small, if the polarities of the sides close to the operation path of the reaction cup are different, a closed magnetic induction line is formed, and effective adsorption of magnetic beads in the reaction cup is finally guaranteed.
Drawings
The technical solution of the present application is further explained below with reference to the drawings and the embodiments.
FIG. 1 is a perspective view of a magnetic cleaning and separating device of an immunoassay analyzer of the present invention;
FIG. 2 is a schematic diagram of the arrangement of the magnets and the arrangement of the magnetic poles of the magnetic cleaning and separating device of the immunoassay analyzer of the present invention.
The reference signs are:
1-reaction cup conveying component, 11-cylinder, 12-disc, 2-cleaning needle component, 3-magnet component, 4-cleaning position, 41-first cleaning position, 42-second cleaning position, 43-third cleaning position and 5-reaction cup.
Detailed Description
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.
The technical solutions of the present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
Examples
The embodiment provides a magnetic cleaning and separating device for an immunoassay analyzer, as shown in fig. 1, comprising a reaction cup conveying assembly 1, a cleaning needle assembly 2, a magnet assembly 3 and a cleaning position 4;
the reaction cup conveying assembly 1 is used for conveying reaction cups 5 to different cleaning positions 4, and specifically, the reaction cup conveying assembly 1 comprises a fixed part and a movable part, a reaction cup running groove is arranged in the fixed part, a containing part for containing the reaction cups 5 is arranged on the movable part, and the movable part can drive the reaction cups 5 to move in the reaction cup running groove;
the cleaning needle assemblies 2 are used for injecting cleaning liquid into the reaction cups 5 in the cleaning positions 4 and sucking the cleaning liquid from the reaction cups 5, and the corresponding cleaning needle assemblies 2 are preferably arranged corresponding to each cleaning station 4, so that the plurality of cleaning needle assemblies 2 can work simultaneously, and the cleaning efficiency is improved;
the magnet assembly 3 comprises two oppositely arranged magnet pairs arranged at two sides of the reaction cup running path and a single magnet arranged at one side of the reaction cup running path, the magnet pairs correspond to the cleaning positions 4 in position, the single magnet is positioned between the cleaning positions 4 or in front of the first cleaning position 4 in the reaction cup running path direction, at least one magnet is arranged at each side of the reaction cup running path between the adjacent cleaning positions 4 or in front of the first cleaning position 4 in the reaction cup running path direction, and the magnets are alternately arranged at two sides of the reaction cup running path and the magnetic pole directions of the adjacent magnets are opposite in the magnet between the adjacent cleaning positions 4 or in front of the first cleaning position 4 in the reaction cup running path direction.
In this embodiment, the single magnet closest to the last washing site in the direction of the travel path of the cuvette is 1-3mm (e.g., 1mm, 2mm, 3mm) higher than the magnet corresponding to the last washing site on the same side as the travel path of the adjacent cuvette, and the single magnet is 3-5mm (e.g., 3mm, 4mm, 5mm) lower than the other magnets.
In this embodiment, adopt square magnet, the magnetic pole direction of magnet is perpendicular with reaction cup traffic route or with the tangent line of traffic route, when the magnetic bead in the reaction cup is adsorbed for the first time, the magnetic bead can be with surface-like distribution in the reaction cup lateral wall, use the magnet to adsorb again at the reaction cup opposite side, the magnetic bead can assemble the center of magnet fast and gather into the punctiform, can make the magnetic attraction maximize of magnetic bead in magnet and the reaction cup 5 like this, strengthen the washing effect of magnetic bead, and can make reaction cup 5 when wasing position 4, attract the magnetic bead on two lateral walls of reaction cup 5 fast, in order to make the washing needle avoid inhaling the magnetic bead in the reaction cup in the washing needle when absorbing the washing liquid in shorter time.
In this embodiment, when the minimum distance between two adjacent magnets on the same side of the reaction cup moving channel is less than 15mm (e.g., 10mm, 12mm, 14mm), the polarities of the two adjacent magnets on the side close to the reaction cup moving channel are the same, otherwise, the two adjacent magnets attract each other to form a closed magnetic induction line, which affects the adsorption of magnetic beads in the reaction cup.
As shown in fig. 1 and 2, the fixed part and the movable part are respectively a cylinder 11 and a disc 12 rotatably arranged in the cylinder, a circular reaction cup running groove is arranged in the cylinder 11, a circle of reaction cup accommodating holes are arranged on the disc 12 in an equal diameter mode, the number of the cleaning positions 4 is three, the first cleaning position 41, the second cleaning position 42 and the third cleaning position 43 are sequentially arranged along the reaction cup transportation direction, a magnet group arranged before each cleaning position 4 is two magnets, and the magnet arranged on one side of the reaction cup running groove close to the center of the reaction cup running groove and the polarity of the magnet are sequentially: s, S, N, N, S, S, the arrangement of the magnets on one side of the reaction cup running groove far away from the circle center of the reaction cup running groove at the magnets on one side close to the reaction cup running groove and the polarities of the magnets are as follows: n, N, S, S, N, N.
In specific implementation, the reaction cup 5 sequentially passes through the first cleaning position 41, the second cleaning position 42 and the third cleaning position 43 through the cup conveying assembly 1, before passing through the first cleaning position 41, magnetic beads in the reaction cup 5 are firstly magnetically attracted to the first magnet to be adsorbed on the cup wall on one side of the reaction cup 5, then the reaction cup 5 passes through the second magnet to be adsorbed on the cup wall on the other side of the reaction cup 5 through the magnetic attraction between the magnetic beads and the second magnet, then the reaction cup 5 passes through the magnet pair corresponding to the first cleaning position 41 to be adsorbed on the cup walls on two sides of the reaction cup 5, at this time, the cleaning needle assembly 2 sucks the cleaning liquid from the reaction cup 5 and injects new cleaning liquid into the reaction cup 5, and then the reaction cup 5 sequentially passes through the magnet group before the second cleaning position 42 and the magnet pair corresponding to the second cleaning position 42, The magnet group before the first cleaning position 41 and the magnet pair corresponding to the first cleaning position 41 repeat the above-mentioned liquid extracting and injecting process at the second cleaning position 42 and the third cleaning position 43; so, not only make the magnetic bead in the reaction cup realize rotating under the effect of the magnet group before washing position 4, broken up the magnetic bead group to effectively wash the magnetic bead, and under the effect of the high magnetic induction intensity who washs the magnet pair that position 4 corresponds, make the magnetic bead attract to two lateral walls of reaction cup fast on, can make the washing needle avoid absorbing the magnetic bead in the reaction cup in the washing needle when the short time absorbs the washing liquid. In addition, the height of the magnet on the single side of the reaction cup running groove corresponding to the last cleaning position and the adjacent magnet is mainly reduced by gradually pulling down the magnetic beads in the reaction cup to the bottom of the reaction cup so as to ensure that the magnetic beads in the reaction cup can fully react with the substrate after the reaction cup enters the measuring chamber.
Further, in this embodiment, except for the single magnet closest to the last cleaning position in the direction of the moving path of the cuvette and the magnet corresponding to the last cleaning position on the same side of the moving path of the adjacent cuvette, the heights of the other magnets are 8-12mm (e.g., 8mm, 10mm, 12mm), and the magnetic induction intensity of the center point of the end surface of the other magnets near the moving path of the cuvette is at least 620mT, which can ensure a good washing effect of magnetic beads.
In this embodiment, the minimum distance between the two magnets of the magnet pair is 6-10mm (e.g. 6mm, 8mm, 10mm), and this design can further enable the magnetic field flow formed by the magnet pair to generate sufficient adsorption capacity for the magnetic beads in the reaction cup 5.
In this embodiment, the magnet is a permanent magnet, such as a neodymium-iron-boron magnet, a samarium-cobalt magnet, or an alnico magnet.
In light of the foregoing description of the preferred embodiments according to the present application, it is to be understood that various changes and modifications may be made without departing from the spirit and scope of the invention. The technical scope of the present application is not limited to the contents of the specification, and must be determined according to the scope of the claims.

Claims (12)

1. A magnetic cleaning and separating device of an immunoassay analyzer is characterized by comprising a reaction cup conveying assembly (1), a cleaning needle assembly (2), a magnet assembly (3) and a plurality of cleaning positions (4);
the reaction cup conveying assembly (1) is used for conveying the reaction cups (5) to different cleaning positions (4);
the cleaning needle assembly (2) is used for injecting cleaning liquid into the reaction cup (5) in the cleaning position (4) and sucking the cleaning liquid from the reaction cup (5);
the magnet assembly (3) comprises two oppositely arranged magnet pairs arranged on two sides of the reaction cup running path and a single magnet arranged on one side of the reaction cup running path, the magnet pairs correspond to the cleaning positions (4), the single magnet is positioned between the cleaning positions (4) or positioned in front of the first cleaning position (4) in the reaction cup running path direction, at least one magnet is arranged on each side of the reaction cup running path between the adjacent cleaning positions (4) or positioned in front of the first cleaning position (4) in the reaction cup running path direction, and the magnets are alternately arranged on two sides of the reaction cup running path or positioned in front of the first cleaning position (4) in the reaction cup running path direction, and the magnetic pole directions of the adjacent magnets are opposite.
2. The magnetic cleaning and separating device for the immunoassay analyzer according to claim 1, wherein the magnet is a square magnet, and the magnetic pole direction of the magnet is perpendicular to the running path of the reaction cup or the tangent of the running path.
3. The magnetic cleaning and separating device for the immunoassay analyzer according to claim 1 or 2, wherein when the minimum distance between two adjacent magnets on the same side of the reaction cup moving path is less than 15mm, the polarities of the two adjacent magnets on the side close to the reaction cup moving path are the same.
4. The magnetic cleaning and separating device for the immunoassay analyzer according to claim 1 or 2, wherein the single magnet closest to the last cleaning position in the direction of the travel path of the cuvettes is 1 to 3mm higher than the magnet corresponding to the last cleaning position on the same side of the travel path of the adjacent cuvettes, and the single magnet is 3 to 5mm lower than the other magnets.
5. The immunoassay meter magnetic wash separation device of claim 1 or 2, wherein the minimum distance between the two magnets of the magnet pair is 6-10 mm.
6. The magnetic cleaning and separating device for the immunoassay analyzer according to claim 1 or 2, wherein the height of the other magnets is 8 to 12mm, and the magnetic induction intensity of the central point of the end surface of the other magnets on the side close to the travel path of the cuvette is at least 620mT, except for the magnet corresponding to the single magnet closest to the last cleaning position in the travel path direction of the cuvette and the magnet corresponding to the last cleaning position on the same side of the travel path of the adjacent cuvette.
7. The magnetic cleaning and separating device of the immunoassay analyzer according to claim 1 or 2, wherein the reaction cup transporting assembly (1) comprises a fixed part and a movable part, the fixed part is provided with a reaction cup running groove, the movable part is provided with a containing part for containing the reaction cup (5), and the movable part can carry the reaction cup (5) to move in the reaction cup running groove.
8. The magnetic cleaning and separating device of the immunoassay analyzer according to claim 7, wherein the fixed part and the moving part are a cylinder (11) and a disc (12) rotatably disposed in the cylinder, a circular reaction cup running groove is disposed in the cylinder (11), and a circle of reaction cup accommodating holes are arranged on the disc (12) in an equal diameter manner.
9. The magnetic cleaning and separating device of the immunoassay analyzer according to claim 7, wherein there are three cleaning positions (4), which are a first cleaning position (41), a second cleaning position (42) and a third cleaning position (43) in sequence along the transporting direction of the cuvettes, the magnet group provided in front of each cleaning position (4) is two magnets, the magnet arrangement and the magnet polarity of the magnet on one side of the cuvette running groove near the center of the cuvette running groove are in sequence: s, S, N, N, S, S, the arrangement of the magnets on one side of the reaction cup running groove far away from the circle center of the reaction cup running groove at the magnets on one side close to the reaction cup running groove and the polarities of the magnets are as follows: n, N, S, S, N, N.
10. The magnetic cleaning and separating device for the immunoassay analyzer according to claim 1 or 2, wherein the magnet is a permanent magnet.
11. The magnetic cleaning and separating device of the immunoassay analyzer of claim 10, wherein the permanent magnet is a neodymium iron boron magnet, a samarium cobalt magnet, or an alnico magnet.
12. An immunoassay analyzer comprising the immunoassay analyzer magnetic cleaning separation device according to any one of claims 1 to 11.
CN201910238859.9A 2019-03-27 2019-03-27 Magnetic cleaning and separating device of immunoassay analyzer Active CN109909217B (en)

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CN201910238859.9A CN109909217B (en) 2019-03-27 2019-03-27 Magnetic cleaning and separating device of immunoassay analyzer
PCT/CN2019/111366 WO2020192091A1 (en) 2019-03-27 2019-10-16 Magnetic cleaning and separating device of immunity analyzer

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Application Number Priority Date Filing Date Title
CN201910238859.9A CN109909217B (en) 2019-03-27 2019-03-27 Magnetic cleaning and separating device of immunoassay analyzer

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CN109909217B (en) * 2019-03-27 2020-10-30 苏州长光华医生物医学工程有限公司 Magnetic cleaning and separating device of immunoassay analyzer
CN112296048A (en) * 2019-07-26 2021-02-02 深圳迎凯生物科技有限公司 Cleaning method
CN110586557B (en) * 2019-09-11 2021-08-20 苏州长光华医生物医学工程有限公司 Cleaning and separating device
CN110672835A (en) * 2019-09-26 2020-01-10 合肥运涛光电科技有限公司 Magnetic separation mechanism for chemiluminescence immunoassay system
CN110823669A (en) * 2019-11-08 2020-02-21 广州科方生物技术股份有限公司 Magnetic separation cleaning method

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