CN109674539A - A kind of tumor marker device - Google Patents
A kind of tumor marker device Download PDFInfo
- Publication number
- CN109674539A CN109674539A CN201811617035.4A CN201811617035A CN109674539A CN 109674539 A CN109674539 A CN 109674539A CN 201811617035 A CN201811617035 A CN 201811617035A CN 109674539 A CN109674539 A CN 109674539A
- Authority
- CN
- China
- Prior art keywords
- marker device
- tumor marker
- adhesive layer
- drug
- solid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3904—Markers, e.g. radio-opaque or breast lesions markers specially adapted for marking specified tissue
- A61B2090/3908—Soft tissue, e.g. breast tissue
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to medical equipment technical fields, more particularly to a kind of tumor marker device, including solid, wrap is equipped with the drug adhesive layer for adhering to anti-tumor drug outside the solid, the external wrap of the drug adhesive layer is equipped with fixing layer, offers several medicine outlets on the fixing layer;The solid and the fixing layer use inert metal material.The device of the invention has the function of that pharmaceutical carrier and label positioning function, drug directly can play therapeutic effect to tumor tissues simultaneously, and inert metal material is also convenient for the identification tracking of radiotherapy apparatus.
Description
Technical field
The invention belongs to medical equipment technical fields, and in particular to a kind of tumor marker device.
Background technique
Tumour can be positioned immediately after tumor marker, to enable radiotherapy apparatus more accurately to navigate to tumour, to mention
High radiotherapy specific aim and accuracy reduce the injury to human health tissue, mitigate patient suffering.The prior art is to tumor marker
There are many device of positioning, for example Chinese patent CN 207085091U discloses a kind of tumor marker device, including marking unit,
The marking unit includes that spherical shape is marked with and truncated cone-shaped mark, and truncated cone-shaped target bottom is connected to the spherical shape and puts on, described
Truncated cone-shaped target axis passes through the spherical target centre of sphere, and the material of the marking unit is titanium alloy.Titanium alloy material is lazy
Property metal material, is easy to tracing and positioning, and human body carries also harmless for a long time, does not influence conventional medical examination also.The device is straight
It connects in merging tumor tissues, the signal blocks that therapeutic equipments will be issued, realizes the locating and tracking to tumour, it is easy to use.In
State patent CN 206809339U discloses a kind of shallow cavity body titanium labelling apparatus, including into titanium mechanism, pricker and ejection mechanism, sharp
With device Xiang Qianti diseased region Implanted Titanium grain to mark lesion region.
Only only label positions a kind of function to above-mentioned labelling apparatus, and without other function.Although its titanium used
To expect that harm to the human body is little, but is foreign matter for the human body after all, merging operation is not easy, if it can be in the titanium material of injection
Other structures, which are added, makes titanium material have drug therapy function vector, then double effects can be played, using instrument to tumour into
After row positioning, certain drug can be injected to anchor point, oncotherapy effect will be greatly improved.
To sum up, it needs to develop a kind of while having the function of pharmaceutical carrier and marking the tumor marker device of positioning function.
Summary of the invention
To solve the above-mentioned problems, of the invention that a kind of tumor marker device is provided, at the same have the function of pharmaceutical carrier and
Mark positioning function.
A kind of tumor marker device provided by the invention, including solid, solid outside wrap, which is equipped with, to be used for
Adhere to the drug adhesive layer of anti-tumor drug, the external wrap of the drug adhesive layer is equipped with fixing layer, on the fixing layer
Offer several medicine outlets;The solid and the fixing layer use inert metal material.
Preferably, in above-mentioned tumor marker device, the shape of the medicine outlet is arc, circle, annular or does not advise
The then curve of shape.
Preferably, in above-mentioned tumor marker device, the shape of the different medicine outlets on each fixing layer is not quite identical.
Preferably, in above-mentioned tumor marker device, raised hemisphere is provided on the drug adhesive layer.
Preferably, in above-mentioned tumor marker device, the radius of the protrusion hemisphere is 0.01-0.01mm.
Preferably, in above-mentioned tumor marker device, the protrusion surface of hemisphere and the table of the drug adhesive layer
Face is provided with several permeability holes.
Preferably, in above-mentioned tumor marker device, diameter≤5 μm of the permeability hole.
Preferably, in above-mentioned tumor marker device, the solid solid cylinder, drug adhesive layer, fixing layer are equal
For the circular cylindrical shell that end is not open, and three is successively arranged from inside to outside;Or the solid is solid cylinder, drug
Adhesive layer, fixing layer are the cylinder tube shape of both ends open, and three is successively arranged from inside to outside;Or the solid, medicine
Object adhesive layer, fixing layer are spherical shell shape, and three is successively arranged from inside to outside.
Preferably, in above-mentioned tumor marker device, the drug adhesive layer uses medical macromolecular materials, natural polymer
Sub- material, inert metal material or ceramic material.
Compared with prior art, a kind of tumor marker device of the invention at least has the advantages that
The effect of solid is the entire tumor marker device of support in the present invention, and drug adhesive layer is for adhering to antineoplastic
Object, fixing layer are used for and tumor contact and tumor marker device are made to be firmly secured to tumour, are convenient for long-term tillage, medicine outlet
Effect is that the drug adhered on drug adhesive layer is made smoothly to dissolve in tumor tissues.The shape of different medicine outlets on each fixing layer
It is not quite identical, there is different frictional force, adhesion strength etc., in addition tumour between irregular drug mouth-shaped and tumor tissues
That organizes is in irregular shape, these medicine outlets of different shapes can combine closely with tumor tissues, further increase tumour mark
Remember stability of the device on tumor tissues.
The device of the invention has the function of pharmaceutical carrier and label positioning function simultaneously, is put into before tumor tissues first
It is placed in drug powder or pharmaceutical carrier and is sufficiently soaked for a period of time, be attached to drug on drug adhesive layer, be then placed in
In tumor tissues, drug directly plays therapeutic effect to tumor tissues, especially when the drug attachment using Thermosensitive Material Used for Controlled Releasing of Medicine preparation
Layer can then play the role of long-term effect, direct drug therapy.If it is the shallow cavities body region such as oral cavity, uterine neck, vagina, can also lead to
Crossing syringe, directly to the medicine outlet of tumor marker device of the present invention, drug progress chemotherapy is penetrated in after-teeming again, is utilized to greatest extent
The device being placed in tumor tissues reduces other foreign matters and is placed in intracorporal operation.
Detailed description of the invention
Fig. 1 is the appearance assumption diagram of 1 tumor marker device of the embodiment of the present invention;
Fig. 2 is the three-dimensional structure diagram of 1 tumor marker device of the embodiment of the present invention;
Fig. 3 is the cross-sectional view of 2 tumor marker device of the embodiment of the present invention;
Fig. 4 is 2 drug adhesive layer surface texture schematic diagram of the embodiment of the present invention;
Fig. 5 is the structural schematic diagram of 4 tumor marker device of the embodiment of the present invention.
Description of symbols:
1. solid, 2. drug adhesive layers, 21. raised hemisphere, 3. fixing layers, 31. medicine outlets.
Specific embodiment
With reference to the accompanying drawing, specific embodiments of the present invention will be described in detail, it is to be understood that guarantor of the invention
Shield range is not limited by the specific implementation.
A kind of tumor marker device, it is specific as shown in Figs. 1-5, including solid 1,1 outside wrap of solid is equipped with medicine
The external wrap of object adhesive layer 2, drug adhesive layer 2 is equipped with fixing layer 3, that is to say, that solid 1, is fixed drug adhesive layer 2
Layer 3 is set gradually from inside to outside.The effect of solid 1 is the entire tumor marker device of support, and drug adhesive layer 2 is anti-for adhering to
Tumour medicine, such as drug powder or drug colloid, fixing layer 3 is used for and tumor contact and is fixedly secured tumor marker device
In in tumour, it is convenient for long-term tillage.In order to make the drug adhered on drug adhesive layer 2 smoothly dissolve in tumor tissues, we are solid
Several medicine outlets 31 are offered in given layer 3.The shape of medicine outlet 31 is the curve of arc, circle, annular or irregular shape,
The shape of different medicine outlets 31 on each fixing layer 3 is not quite identical, irregular 31 shape of medicine outlet and tumor tissues it
Between there is different frictional force, adhesion strength etc., tumor tissues is in irregular shape in addition, these 31 energy of medicine outlet of different shapes
It is enough to combine closely with tumor tissues, further increase stability of the tumor marker device on tumor tissues.
The material of solid 1 and fixing layer 3 uses inert metal material, such as proof gold, titanium alloy, these materials are to human body
It is harmless, it can be used for a long time, be also convenient for the identification tracking of radiotherapy apparatus.Drug adhesive layer 2 is preferable or right using describing property of biology
The medical macromolecular materials such as human injury lesser material, such as medical silica-gel film, synthetic fibers, albumin, polypeptide, day
The natural macromolecular materials such as right rubber, the inert metals material such as niobium titanium alloy layer, ceramic material.The present invention includes following implementation
Example.
Embodiment 1
A kind of tumor marker device, as shown in Figs. 1-2, including solid 1, it is attached that 1 outside wrap of solid is equipped with drug
Layer 2, the external wrap of drug adhesive layer 2 be equipped with fixing layer 3;1 solid cylinder of solid, drug adhesive layer 2, fixing layer
3 be the circular cylindrical shell that end is not open, and three is successively arranged from inside to outside;Or solid 1 is solid cylinder, drug
Adhesive layer 2, fixing layer 3 are the cylinder tube shape of both ends open, and three is successively arranged from inside to outside;On 3 side wall of fixing layer
31 shape of medicine outlet has arc and semicircle.The material of solid 1 and fixing layer 3 uses inertia titanium alloy material, drug attachment
2 niobium titanium alloy layer of layer.
Embodiment 2
A kind of tumor marker device, structure is substantially the same manner as Example 1, and difference is: being provided on drug adhesive layer 2 convex
Hemisphere 21 is played, referring to Fig. 3-4, the radius of raised hemisphere 21 is 0.01-0.01mm, and the presence of raised hemisphere 21 makes drug adhesive layer
There are gap between 2 and fixing layer 3, attachment can be protruded into tumor tissues with the drug on drug adhesive layer 2 along secondary gap.
Embodiment 3
A kind of tumor marker device, structure is substantially the same manner as Example 2, and difference is: the surface of raised hemisphere 21 and
The surface of drug adhesive layer 2 is provided with several permeability holes, diameter≤5 μm of permeability hole.The setting of permeability hole increases drug
With the contact area of drug adhesive layer 2, increase drug loading, increases drug loading firmness.Drug adhesive layer 2 is using ceramics
Material.
Embodiment 4
A kind of tumor marker device, as shown in figure 5, including solid 1,1 outside wrap of solid is adhered to equipped with drug
The external wrap of layer 2, drug adhesive layer 2 is equipped with fixing layer 3, and solid 1, drug adhesive layer 2, fixing layer 3 are spherical shell shape,
And three is successively arranged from inside to outside.The material of solid 1 and fixing layer 3 uses inertia titanium metal material, and drug adhesive layer 2 is adopted
With medical silica-gel film, the shape of medicine outlet 31 is round, arc or annular on fixing layer 3.
It should be noted that can also be on 3 lateral wall of fixing layer of the tumor marker device of embodiment 1-4 any embodiment
It is fixed with attachment ear, attachment ear is spheroid-like, convenient in conjunction with tumor tissues.
It should be noted that repeating in order to prevent, the present invention describes preferred embodiment, but technology people in the art
Member is once know basic creative concept, then additional changes and modifications can be made to these embodiments.So appended right
It is required that being intended to be construed to includes preferred embodiment and all change and modification for falling into the scope of the invention.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
Mind and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to include these modifications and variations.
Claims (9)
1. a kind of tumor marker device, which is characterized in that including solid (1), the external wrap of the solid (1), which is equipped with, to be used
Fixing layer (3) are equipped in the external wrap of the drug adhesive layer (2) of attachment anti-tumor drug, the drug adhesive layer (2), institute
It states and offers several medicine outlets (31) on fixing layer (3);The solid (1) and the fixing layer (3) use inert metal material
Material.
2. tumor marker device according to claim 1, which is characterized in that the shape of the medicine outlet (31) be arc,
Round, annular or irregular shape curve.
3. tumor marker device according to claim 2, which is characterized in that the different medicine outlets on each fixing layer (3)
(31) shape is not quite identical.
4. tumor marker device according to claim 1, which is characterized in that be provided on the drug adhesive layer (2) convex
It rises hemisphere (21).
5. tumor marker device according to claim 4, which is characterized in that it is described protrusion hemisphere (21) radius be
0.01-0.01mm。
6. tumor marker device according to claim 4, which is characterized in that the surface of the protrusion hemisphere (21) and institute
The surface for stating drug adhesive layer (2) is provided with several permeability holes.
7. tumor marker device according to claim 6, which is characterized in that diameter≤5 μm of the permeability hole.
8. tumor marker device according to claim 1, which is characterized in that solid (1) solid cylinder, drug
Adhesive layer (2), fixing layer (3) are the circular cylindrical shell that end is not open, and three is successively arranged from inside to outside;Or the reality
Heart body (1) is solid cylinder, and drug adhesive layer (2), fixing layer (3) are the cylinder tube shape of both ends open, and three is by interior
It is successively arranged outward;Or the solid (1), drug adhesive layer (2), fixing layer (3) are spherical shell shape, and three is by introversion
It is successively arranged outside.
9. tumor marker device according to claim 1-8, which is characterized in that the drug adhesive layer (2) is adopted
With medical macromolecular materials, natural macromolecular material, inert metal material, Thermosensitive Material Used for Controlled Releasing of Medicine or ceramic material.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811617035.4A CN109674539B (en) | 2018-12-28 | 2018-12-28 | Tumor marking device |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811617035.4A CN109674539B (en) | 2018-12-28 | 2018-12-28 | Tumor marking device |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109674539A true CN109674539A (en) | 2019-04-26 |
CN109674539B CN109674539B (en) | 2022-01-21 |
Family
ID=66190791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811617035.4A Active CN109674539B (en) | 2018-12-28 | 2018-12-28 | Tumor marking device |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109674539B (en) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105963806A (en) * | 2016-04-28 | 2016-09-28 | 创领心律管理医疗器械(上海)有限公司 | Auxiliary equipment and preparation method thereof |
US20170066162A9 (en) * | 2006-03-28 | 2017-03-09 | Devicor Medical Products, Inc. | Method of Enhancing Ultrasound Visibility of Hyperechoic Materials |
CN106552326A (en) * | 2017-02-06 | 2017-04-05 | 中国人民解放军总医院 | Tumor-localizing device |
CN106621076A (en) * | 2017-02-06 | 2017-05-10 | 浙江荣诚医疗科技有限公司 | Cobalt-zirconium gold marker implant and gold marker implantation apparatus |
CN106691598A (en) * | 2017-02-06 | 2017-05-24 | 浙江荣诚医疗科技有限公司 | Gold mark with coating and coating location device |
CN206372136U (en) * | 2016-08-23 | 2017-08-04 | 北京大学深圳医院 | Tumor of breast bulb positioner |
CN107715307A (en) * | 2017-09-26 | 2018-02-23 | 李铭 | A kind of tumor-localizing device |
-
2018
- 2018-12-28 CN CN201811617035.4A patent/CN109674539B/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170066162A9 (en) * | 2006-03-28 | 2017-03-09 | Devicor Medical Products, Inc. | Method of Enhancing Ultrasound Visibility of Hyperechoic Materials |
CN105963806A (en) * | 2016-04-28 | 2016-09-28 | 创领心律管理医疗器械(上海)有限公司 | Auxiliary equipment and preparation method thereof |
CN206372136U (en) * | 2016-08-23 | 2017-08-04 | 北京大学深圳医院 | Tumor of breast bulb positioner |
CN106552326A (en) * | 2017-02-06 | 2017-04-05 | 中国人民解放军总医院 | Tumor-localizing device |
CN106621076A (en) * | 2017-02-06 | 2017-05-10 | 浙江荣诚医疗科技有限公司 | Cobalt-zirconium gold marker implant and gold marker implantation apparatus |
CN106691598A (en) * | 2017-02-06 | 2017-05-24 | 浙江荣诚医疗科技有限公司 | Gold mark with coating and coating location device |
CN107715307A (en) * | 2017-09-26 | 2018-02-23 | 李铭 | A kind of tumor-localizing device |
Also Published As
Publication number | Publication date |
---|---|
CN109674539B (en) | 2022-01-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2944139T3 (en) | Ultrasonic drug delivery to urinary bladder | |
JP5769775B2 (en) | Access port and identification method | |
ES2409758T3 (en) | Tissue site markers for in vivo imaging | |
US20070238983A1 (en) | Fiduciary Markers and Method of Use thereof | |
JP2003510136A (en) | Method and apparatus for locating the injection point of an implanted medical device | |
JP2017094174A (en) | Cannula with insertion depth limited | |
BRPI0518383A2 (en) | Chargeable polymeric particles for therapeutical and / or diagnostic applications and methods for preparing and using them | |
US9364165B2 (en) | Apparatus and method for moving and activating an active agent | |
Abrbekoh et al. | Application of microneedle patches for drug delivery; doorstep to novel therapies | |
Amourizi et al. | Polymeric and composite-based microneedles in drug delivery: regenerative medicine, microbial infection therapy, and cancer treatment | |
Kilroy et al. | Localized in vivo model drug delivery with intravascular ultrasound and microbubbles | |
JP2006517127A (en) | Seed spacer string end cap for brachytherapy | |
Shidhaye et al. | Pulsatile Delivery Systems: An Approach for Chronotherapeutic Diseases. | |
CN109674539A (en) | A kind of tumor marker device | |
JP7037026B2 (en) | Cap and applicator for anesthesia syringe body | |
Häfeli | The history of magnetism in medicine | |
CN106691598A (en) | Gold mark with coating and coating location device | |
JP2009525801A (en) | Apparatus for monitoring patient status and treatment based on the status | |
KR102083658B1 (en) | Microneedle system having flow passage inside | |
JP6777088B2 (en) | Dosing device | |
Stewart et al. | Capsule-based ultrasound-mediated targeted gastrointestinal drug delivery | |
CN107715307A (en) | A kind of tumor-localizing device | |
CN207085091U (en) | Tumor marker device | |
CN209108439U (en) | Position the fiducial marker of target tissue | |
JP2004283289A (en) | Balloon catheter with ultrasonic marker, and chemical injection/blood vessel insertion catheter |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |